Cytochrome P450 3As Gene Expression and Testosterone 6

摘要

Expression levels of cytochrome P450 (CYP) 3A4, CYP3A5 and CYP3A7 mRNAs in placentas and fetalmembranes, which were split into amnion and chorion leave attached decidua (chorion/decidua), obtained frompregnant women with normal delivery (5 subjects) and Caesarean section (15 subjects) were determined. TheseCYP3A mRNAs were also expressed in amnion and chorion/decidua together with placenta, although the expres-sion level of these mRNAs was strikingly different between subjects. The expression level of the CYP3A4 mRNAin the placenta was about 2-fold higher than those in amnion and chorion/decidua. On the other hand, the ex-pression levels of CYP3A5 and CYP3A7 mRNAs were highest in chorion/decidua. The immunologically relatedprotein(s) with CYP3A7 was detected in all tissues examined. Testosterone 6