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DESIGN OF BIAPTAZYME WITHOUT SELF-CLEAVAGE ACTIVITY OF RIBOZYME AND ITS APPLICATION TO BIOSENSOR OR BIOCHIP DEVELOPMENT
DESIGN OF BIAPTAZYME WITHOUT SELF-CLEAVAGE ACTIVITY OF RIBOZYME AND ITS APPLICATION TO BIOSENSOR OR BIOCHIP DEVELOPMENT
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机译:不具有核酶自我裂解活性的双歧酶的设计及其在生物传感器或生物芯片开发中的应用
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摘要
The present invention is a sensing of the biological material that the application as a sensor of this development and bio-chip and the microfluidic chip systems applying the biomaterial (sensing), detection, diagnosis, and belongs to the field of gene therapy. ; In developing that Eph Tamer and ribozyme conjugates of Eph batter, in being an Eph batter developed in previous studies and showed the absence of the target substance, self-decomposition, self-decomposition of the ribozyme only when there is in the present invention, the target substance developed an Eph batter any design method - by reaction to produce the animation system (stem) I and designed for fusion (fusion) with the Eph Tamer in stem III, a more sensitive and activated by good. Use them to recognize the real-time as proteins, cells, and biological material by fluorescence in the microfluidic chip system of multiple channels, develop new Eph batter being chip system to make a double through again the mass analyzer to a sensitive material will be. ; Purpose of the invention is a signal as to detect biological material without the noise and develop a biosensor for diagnosis, first, may be used as a sensor that can detect a specific substance with this, the fluorescence when applying it to the biochip to the microfluidic chip, and can be used like a two-dimensional analysis is possible to diagnose and analyze in real time through the mass analyzer. ; This also applies to a specific gene by an external substances through the development of effective design in the study of gene therapy that can be cut is possible. ; Ribozymes, Tamer Ephesians, Ephesians hitter Im bi-hitter Ephesians Lim, biochips
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