SYNTHESIS OF CHIRAL ENAMINONES, THEIR DERIVATIVES, AND BIOACTIVITY STUDIES THEREOF

摘要

This invention provides enantioenriched heterocyclic enaminone compounds with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I):; ;comprising treating a compound of formula (II):; ;with a transition metal catalyst under alkylation conditions.