Development of Aminoacetylene Derivatives for Effective Synthesis of Organonitrogen Bioactive Compounds

摘要

Over the past decades, a number of organic chemists have attempted to construct C(sp)–N bond to synthesize organonitrogen compounds. However, the target aminoacetylenes (ynamines) are highly labile because of their high nucleophilicity, and also the development of a practical protocol for their subsequent transformation to other organonitrogen compounds remains still in demand. Recently, we succeeded to synthesize air-stable aminoacetylenes by installing electron-withdrawing phosphoryl (Ph2P(O)) group.