COMPOSITIONAL STUDIES OF OIL AND ANTIOXIDANT CAPACITY OF OIL AND EXTRACTS OF Diarthron vesiculosum

摘要

The present study was carried out to examine the antioxidant, antimicrobial and haemolytic activities of different extracts, fractions and oils (essential and fixed) of Diarthron vesiculosum. GC-MS analysis revealed the presence of 18 and 16 compounds in the essential and fixed oils, respectively with 1,2-benzenedicarboxylic acid, diisooctyl ester (35.94 %), 1-(+)-ascorbic acid 2,6-dihexadecanoic (12.24%), Z,Z-3,13-octadecadien-1-ol (14.08 %), 9,12-octadecadienoic acid (Z,Z)-2,3-dihydroxypropyl ester (11.02%) as the major components. The extracts contained appreciable levels of total phenolic and total flavonoid contents and exhibited good DPPH radical scavenging activity, (IC50 0.39-21.5 mg/ml), and inhibition of peroxidation in linoleic acid system (65.8-89.3%). Moderate to high antimicrobial activity against selected strains of bacteria and fungi was observed. The extracts exhibited 2.84 to 13.15% haemolysis of red blood cells. The results of the present investigation demonstrated significant (p < 0.05) variations in the antioxidant, antimicrobial and haemolytic potential of the plant extracts and fractions.