Reaction of Alkyl 5,5-Dimethyl-2-oxo-2,5-dihydrofuran-3-carboxylates with Zinc Enolates Prepared from Zinc and l-Arul-2-bromo-2-phenylethanones,2 Bromoindanone,and 2-Bromo-6-methyltetralone

摘要

Alkyl 5,5-dimethyl-2-oxo-2,5-dihydrofuran-3-carboxylates react with zinc enolates prepared from l-aryl-2-bromo-2-phenylethanones,2-bromoindanone,2-bromo-6-methyltetralone and zinc with formation of ethyl 4-(2-aryl-2-oxo-l-phenyl-ethyl)-5,5-dimethyl-2-oxotetrahydrofuran-3-carboxylates,alkyl 5,5-dimethyl-2-oxo-4-(l-oxoindan-2-yl)tetrahydrofuran-3-carboxylates,and ethyl 5,5-dimethyl-4-(6-methyl-l-oxo-l,2,3,4-tetra-hydronaphthalen-2-yl)-2-oxotetrahydrofuran-3-carboxylate respectively,mainly as single diastereomers.