Synthesis of 3-{4-[4-dimethylamino-6-(4-methyl-2-oxo-2H-chromen-7-yloxy)-[1,3,5]triazin-2-ylamino]-phenyl}-2-phenyl-5-(4-pyridin-2-yl-piperazin-l-ylmethyl)-thiazoHdin-4-one and their biological evaluation

摘要

A novel series of thiazolidinone derivatives namely 3-{4-[4-dimethylamino-6-(4-methyl-2-oxo-2H-chromen-7-yloxy)-[1,3,5]triazin-2-yIamino]-phenyl}-2-phenyl-5-(4-pyridin-2-yl-piperazin-l-ylmethyl)-thiazolidin-4-one have been synthesized from the intermediate 7-[4-(4-amino-phenylamino)-6-dimethylamino-[1,3,5]triazin-2-yloxy]-4-methyl-chromen-2-one (7). Condensation reaction of compound 7 with different aldehyde derivatives were performed to give Schiff base derivatives, which after cyclization gave thiazolidinones and they were incorporated with 1-pyridin-2-yl-piperazine to get target compounds. The newly synthesized compounds were evaluated for their antimicrobial activity against eight bacteria (S. aureus, B. cereus, E. coli, P. aeruginosa, K. pneumo-niae, S. typhi, P. vulgaris, and S. flexneria) and four fungi (A. niger, C. albicans, A. fumigatus, and A. clavatus).