Food proteins as precursors of bioactive peptides - Classification into families

摘要

The Bioactive Peptides (BIOPEP) database developed at the Department of Food Biochemistry, University of Warmia and Mazury in Olsztyn was used to determine the profiles of the potential biological activity of food proteins and to classify them into families. Proteins whose amino acid sequences contained fragments with a specified activity and which were a potential source of this activity were divided into families. Among the 44 biological activities of peptides included in the BIOPEP database, 23 were selected for analysis. The number of families was diversified. The largest families were composed of proteins precursors of antihypertensive peptides and dipeptidyl aminopeptidase IV inhibitors as well as those activating ubiquitin-mediated proteolysis and opioid ones. Only a few proteins included in the database contained in their sequences fragments with the following activities: chemotactic, binding and transporting metals and metal ions, stimulating red blood cells synthesis, inducing contractions of smooth muscles, and hemolytic. Highly numerous families were divided into five sub-families according to the value of the frequency of occurrence of fragments exhibiting given activity (A parameter).