SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NEW SUBSTITUTED AZETIDINONYL INDOLYLTRIAZOLE DERIVATIVES

摘要

Cyclocondensation of 4-[2'-substituted alkyl/aryl-5'-methoxy-3'-indolylideno]-3-ethanethioat-5-(substituted phenyl)-1,2,4-triazoles (3a-3h) and 4-[2'-substituted alkyl/aryl-5'-methoxy-3'-indolylideno]-3-benzothioat-5-(substituted phenyl)-1,2,4-triazoles (4a-4h) with chloroacetyl chloride give 4-[3'-chloro-2"-(2-substJtuted alkyl/aryl-5'-methoxy-3'-indolylideno)-4"-oxoazetidinyl]-3-ethanethioat-5-(substituted phenyl)-1,2,4-triazoles (5a-5h) and 4-[3"-chloro-2"-(2-substituted alkyl/ary1-5-methoxy-3'-indolylideno)-4"-oxoazetidinyl]-3-benzothioat-5-(substituted phenyl)-1,2,4-triazoles (6a-6h) respectively. All the synthesized compounds were screened for their antibacterial activity and compared with reference drugs ciprofloxacin and gattifloxacin. The compound 5h was the most potent compound of this series. This compound exhibited promising antibacterial activity against S. aureus (26mm), E. coli (24mm), P. vulgaris (22mm) and K. pneumoniae (23mm). Structure of all the synthesized compounds have been characterized by elemental (C, H, N) and spectral (IR and ~1HNMR) analysis.