Design and preclinical characterization of ALXN1210: A next generation anti-C5 monoclonal antibody with improved pharmacokinetics and duration of action

Sheridan Douglas; Yu Zhao-Xue; Zhang Yuchun; Patel Rekha; Lasaro Melissa; Bouchard Keith; Andrien Bruce; Marozsan Andre; Wang Yi; Tamburini Paul

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Design and preclinical characterization of ALXN1210: A next generation anti-C5 monoclonal antibody with improved pharmacokinetics and duration of action

机译：ALXN1210的设计和临床前表征：具有改善的药代动力学和作用持续时间的下一代抗C5单克隆抗体

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《Immunobiology: Zeitschrift fur Immunitatsforschung》 |2016年第10期|共1页
作者
Sheridan Douglas; Yu Zhao-Xue; Zhang Yuchun; Patel Rekha; Lasaro Melissa; Bouchard Keith; Andrien Bruce; Marozsan Andre; Wang Yi; Tamburini Paul;
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正文语种 eng
中图分类医学免疫学;
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1. Design and preclinical characterization of ALXN1210: A next generation anti-C5 monoclonal antibody with improved pharmacokinetics and duration of action [J] . Sheridan Douglas, Yu Zhao-Xue, Zhang Yuchun, Immunobiology: Zeitschrift fur Immunitatsforschung . 2016,第10期

机译：ALXN1210的设计和临床前表征：具有改善的药代动力学和作用持续时间的下一代抗C5单克隆抗体
2. Generic Automated Method for Liquid Chromatography-Multiple Reaction Monitoring Mass Spectrometry Based Monoclonal Antibody Quantitation for Preclinical Pharmacokinetic Studies [J] . Qian Zhang, Daniel S. Spellman, Yaoli Song, Analytical chemistry . 2014,第17期

机译：基于液相色谱-多反应监测质谱的通用自动化方法用于临床药代动力学研究的单克隆抗体定量
3. Mimicking Natural Antibody Recycling for In Vitro Pharmacokinetics Studies:FcRn Affinity Chromatography Improves Functional Characterization of Monoclonal Antibodies [J] . Tilman Schlothauer Genetic Engineering & Biotechnology News: The Information Source of the Biotechnology Industry . 2018,第9期

机译：模拟用于体外药代动力学研究的天然抗体再循环：FCRN亲和层析改善单克隆抗体的功能性表征
4. High Throughput and Multiplexed LC-MS/MS Bioanalysis of Therapeutic Monoclonal Antibodies for Preclinical Pharmacokinetic Studies [C] . Hongyan Li, Robert Ortiz, Linh T.B. Tran, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：高通量和多重LC-MS / MS生物分析治疗单克隆抗体临床前药代动力学研究
5. Characterization of Anti-Ricin Monoclonal Antibodies and the Construction of a Chimeric Murine-Human IgG2/K Anti-Ricin Monoclonal Antibody [D] . Vendramelli, Robert Matthew 2011

机译：抗蓖麻毒蛋白单克隆抗体的表征和鼠/人IgG2 / K嵌合抗蓖麻毒蛋白单克隆抗体的构建
6. Design and preclinical characterization of ALXN1210: A novel anti-C5 antibody with extended duration of action [O] . Douglas Sheridan, Zhao-Xue Yu, Yuchun Zhang, -1

机译：ALXN1210的设计和临床前表征：具有延长作用时间的新型抗C5抗体
7. Preclinical pharmacokinetics, interspecies scaling, and pharmacokinetics of a Phase I clinical trial of TTAC-0001, a fully human monoclonal antibody against vascular endothelial growth factor 2 [O] . Weon Sup Lee, Sang Ryeol Shim, Seon Young Lee, 2018

机译：临床前药代动力学，Interpecies缩放和TTAC-0001的临床试验的药代动力学，一种针对血管内皮生长因子2的全人单克隆抗体2

Design and preclinical characterization of ALXN1210: A next generation anti-C5 monoclonal antibody with improved pharmacokinetics and duration of action

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