Synthesis and Antibacterial Activity of 2-Amino-4-(2',4'-Dichloro-5'-Fluorophen-1'-yl)-6-Aryl Pyrimidine Derivatives and Related Compounds

摘要

2',4'-Dichloro-5'-fluorochalcones (1a-j)react with an alcoholic solution of guanidine nitrate containing aqueous sodium hydroxide solution to give the corresponding 2-amino-4-(2',4'-dichloro-5'fluorphen-1'-yl)-6-aryl pyrimidines (2a-j). Comounds(2a-j) were converted to diacetyl (3a-j);sulphonamide (4a-j);and N-acetyl sulphonamide (5a-j) pyrimidine derivitives. These varied products have been characterised by spectral studies and screened for antibacterial activiity.