Cytochrome P450-mediated interaction between perazine and risperidone: implications for antipsychotic polypharmacy

摘要

BackgroundAlthough clinically widespread, scientific evidence for antipsychotic polypharmacy is still limited. Combining different drugs increases the potential for drug-drug interactions, enhancing the risk of adverse drug reactions. We aimed to unravel the potential pharmacokinetic interactions between risperidone (RIS) and perazine.