An efficient synthesis of 1,4-disubstituted triazoles in water via CuCl _2/Zn-catalyzed huisgen cycloaddition

摘要

An efficient method for the synthesis of 1,4-disubstituted triazoles in water at room temperature has been developed using CuCl _2/Zn as a catalyst system. Under the optimized conditions, a novel series of 1,4-disubstituted 1,2,3-triazoles were synthesized.