目的 考察大鼠灌胃口服复方血栓通片后人参皂苷Rb1与Rg1在大鼠体内的药代动力学特征.方法 通过建立测定血浆中人参皂苷Rg1与Rb1的液质联用色谱法(LC-MS),测定8只大鼠灌胃给1 200 mg· kg-1的复方血栓通片后的血药浓度,通过DAS软件进行药代动力学统计分析.结果 大鼠灌胃给1200mg·kg-1的复方血栓通片后,血浆中人参皂苷Rb1与Rg1达峰时间均快,分别为1.02 h与1.05 h；与人参皂苷Rb1相比,人参皂苷Rg1原形在胃肠吸收较差,生物利用度低；人参皂苷Rb1半衰期长[(16.45±3.17)h]而人参皂苷Rg1半衰期短[(4.33±1.34)h].结论 复方血栓通片中人参皂苷Rb1与Rg1的药代动力学研究对含该组分的新药研发和制剂研究等有一定的意义.%Objective To investigate the pharmacokinetic behavior of ginsenoside Rgl and Rbl after intragastric administration of Fufang Xueshuantong tablets in rats. Methods The LC-MS was established to determine the blood drug concentrations of ginsenoside Rgl and Rbl after intragastric administration of Fufang Xueshuantong tablets (1 200 mg ? kg-1) in 8 rats. Statistical analysis of pharmacokinetic data was carried out by DAS. Results After intragastric administration of Fufang Xueshuantong tablets,plasma concentrations of ginsenoside Rgl and Rbl reached maximum values quicklyd. 02 h, 1. 05 h). The absorption of Rgl was poorer and the bioavailabili-ty was lower as compared to Rbl. Moreover, the half life of Rbl was longer than that of Rgl [(16. 45 + 3. 17) hours vs (4. 33±1. 34) hours]. Conclusion The pharmacokinetic behavior of ginsenoside Rgl and Rbl in Fufang Xueshuantong tablets has positive significance in the study of new drugs and preparations containing ginsenoside Rgl and Rbl.
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