癫痫患者脑电图特征与血清细胞因子、神经分子、凋亡分子的相关性研究

摘要

目的:研究癫痫患者脑电图特征与血清细胞因子、神经分子、凋亡分子的相关性.方法:选择在榆林市第一医院诊断为癫痫的患者作为研究的癫痫组,选择同期在榆林市第一医院体检的健康者作为对照组,进行脑电图检查并测定EEG放电指数,采集血清并测定细胞因子、神经分子、凋亡分子的含量.结果:癫痫组患者的EEG放电指数显著高于对照组;癫痫组患者血清中IL-2、TNF-α、IFN-γ、HMGB-1、S100B、NSE、GFAP、Bax、Caspase-3的含量均显著高于对照组且与EEG放电指数呈正相关,CGRP、Bcl-2的含量显著低于对照组且与EEG放电指数呈负相关.结论:癫痫患者神经元的异常放电与免疫及炎症细胞因子的异常分泌有关并且会造成神经细胞过度损伤及凋亡.%Objective:To study the correlation of electroencephalogram characteristics with serum cytokines,nerve molecules and apoptosis molecules in patients with epilepsy.Methods:Patients who were diagnosed with epilepsy in the First Hospital of Yulin between March 2015 and February 2017 were selected as the epilepsy group of the research and healthy subjects who received physical examination in the First Hospital of Yulin during the same period were selected as the control group.EEG examination was conducted to determine EEG discharge index,and serum was collected to determine the contents of cytokines,nerve molecules and apoptosis molecules.Results:EEG discharge index of epilepsy group was significantly higher than that of control group;serum IL-2,TNF-α,IFN-γ,HMGB-1,S100B,NSE,GFAP,Bax and Caspase-3 contents of epilepsy group were significantly higher than those of control group and positively correlated with EEG discharge index while CGRP and Bcl-2 contents were significantly lower than those of control group and negatively correlated with EEG discharge in dex.Conclusion:The abnormal neuron discharge in patients with epilepsy is associated with the abnormal secretion of immune and inflammatory cytokines and can cause excessive damage and apoptosis of nerve cells.