isolated polypeptide, isolated nucleic acid molecule, vector, isolated host cell, packaging cell line, biocompatibly implantable cellular device, pharmaceutical composition, use of the polypeptide, or isolated nucleic acid sequence, or expression vector, or composition of host cells, or a biocompatibly implantable cellular device or a packaging cell line, method of treating a pathological condition in an individual, methods for preventing apoptosis in a mammalian neuronal cell, to enhance the survival of a neuronal cell mammalian cells, to generate a neuron, to expand a mammalian cell composition, and to differentiate a mammalian cell composition, antibody, and, immunoconjugate

摘要

ISOLATED POLYPEPTIDE, ISOLATED NUCLEIC ACID MOLECLE, VECTOR, ISOLATED HOST CELL, PACKAGING CELL LINE, IMPLANTABLE OR PHARMACEUTICAL COMPULSION, OR IMPLEXED COMPULSION, OF HOST CELLS, OR AN IMPLANTABLE BIOCOMPATIBLE CELL DEVICE OR PACKAGING CELL LINE, METHOD OF TREATMENT OF A PATHOLOGICAL CONDITION IN AN INDIVIDUAL TO PREVENT NEULAR A CELL IN A NEEDLE This invention relates to the field of therapeutic use of cells, genes, and genes. More specifically the invention relates to therapy based on the biological function of a secreted therapeutic protein, NsG33, in particular for the treatment of nervous system disorders. NsG33 is a nerve growth and survival factor with anti-apoptopic effects on a neuronal potential cell line and with neuroprotective and / or neurogenic effects on a neural precursor cell line and primary striatal cultures. The invention also relates to novel bioactive NsG33 polypeptide fragments and the corresponding coding DNA sequences.