Amyotrophic lateral sclerosis (ALS), including the familial and the sporadic, accounts for the most proportion of motor neu-ron disease. The pathogenesis of ALS covers gene mutation, oxidative stress, excitotoxicity, mitochondrial dysfunction, immune and inflam-matory, and so on. With interplay and interrelation, these mechanisms, finally, caused multisystem lesion especially motor neural system.%肌萎缩侧索硬化(ALS)是最常见的一种运动神经元疾病,分为家族性和散发性.一般认为,ALS的发病机制主要包括基因突变、氧化应激、兴奋毒性、线粒体异常和免疫炎症反应等.这些发病机制之间相互联系,相互影响,最终引起了以运动神经系统为主的多系统病变.
展开▼
