Synthesis and characterization of Heck-cross coupling 4-(4-nitrostyryl) aniline as potential precursor in Schiff-base synthesis

摘要

This is a preliminary study of alkoxy substituted Heck-schiff base compound as recognition layer in electrochemical DNA sensor for liver cancer. 4-(4-nitrostyryl)aniline was synthesized by bis (triphenylphosphine) palladium (II) dichloride as catalyst and has been characterized by using Fourier transform-infrared spectrometer (FTIR), UV-Vis spectrophotometer and Nuclear Magnetic Resonance (NMR) spectra. The result obtained from FTIR show that there are formation of N=O (NO_2) asymmetric stretching vibrations 1340 cm~(-1). In UV-vis, absorbance of NO_2 can be observed at peak 410 nm. While in the ~1H NMR and ~(13)C NMR the peak of C-C coupling was found in the range of δ_H 6.84-7.09 ppm and δ_C 125.23 ppm.