Intracranial and cerebral perfusion pressure management in traumatic brain injury

摘要

Advances in the understanding of the pathophysiology of traumatic brain injury have influenced clinical management. In 1783, the Monro-Kelly doctrine, outlining the asymptotic relationship between intracranial pressure (ICP) and volume was defined. The concept of exhausted intracranial elastant reserve is as valid today, particularly when reviewing past, current, and new therapies for traumatic brain injury.