Targeted Gene Delivery into Peripheral Nervous System Mediated by Trimethyl Chitosan Nanoparticles

摘要

The fixed positive charges on TMC facilitated their association with DNA in physiological conditions, yielding more stable particles. This resulted in higher internalization levels and DNA vectoring to the nucleus, resulting in a more efficient transfection of cells. Moreover, the functionalized particles presented an increased specificity towards the neuronal population.