CD44 siRNA A siRNA gene delivery system comprising chitosan nanoparticle bounded to hyaluronic acid that targeting CD44 receptor specifically expressed in endothelial cell of angiogenesis

摘要

The present invention relates to an siRNA gene carrier comprising hyaluronic acid-bound chitosan nanoparticles and a composition for treating cancer comprising the same, wherein the hyaluronic acid-bound chitosan nanoparticles according to the present invention can be used as an siRNA carrier, By targeting CD44 receptor overexpressed in vascular endothelial cells of the tumor, it is possible to selectively inhibit the gene specifically expressed in the vascular endothelial cells of the tumor, and to suppress the neovascularization of the tumor.;