PROCESS FOR THE PREPARATION OF 7-ALCOXYCARBONYL-6,8-DIMETHYL-4-HYDROXYMETHYL-1-PHTALAZONES AND THEIR INTERMEDIATES AND PRODUCTS THUS OBTAINED

摘要

IN THIS PROCESS, 7-ALCOXYCARBONYL-6,8-DIMETHYL-4-HYDROXYMETHYL-1-PHTHALAZONES MAY BE OBTAINED BY THE REACTION OF A SUBSTITUTED METHYLENETRIPHENYLPHOSPHORANE WITH 3,5-DIMETHYL-4-ALCOXYCARBONYLPHTALIC ANHYDRIDE TO OBTAIN 6 -ALCOXY-CARBONYL-5,7-DIMETHYL-METHYLENE (SUBSTITUTED) -PHTALIDE, THE REACTION THEREOF WITH HYDRAZINE TO OBTAIN A PHTHALAZONE DERIVATIVE, THE HYDROLYSIS THEREOF, THE HALOGENATION OF HYDROLYSAT FOR HAVE 7-ALCOXYCARBONYL-6,8-DIMETHYL-4- (A-HALOGENO-A-METHYL (SUBSTITUTED)) - 1-PHTALAZONE A, THEN DIRECT HYDROLYSIS AND DECARBOXYLATION THEREOF, OR IF THERE IS IS 7-ALCOXYCARBONYL-6,8-DIMETHYL-1-PHTHALAZONE-4-A-HALOGENO-ACETIC ACID, BY THE REACTION OF THIS ACID WITH A CARBOXYLIC ACID SALT, THEN SIMULTANEOUS DECARBOXYLATION OF THE ACYLOXYL PRODUCT AND THE HYDROLYSIS OF THE DECARBOXYL OR THE INITIAL DECARBOXYLATION OF THE ACID IN QUESTION BY REACTING THE DECARBOXYL PRODUCT WITH THE SAME CARBOXYLIC ACID SALT THEN THE HYDRO LYSE OF THE REACTION PRODUCT; OR THEREFORE IF THE PHTHALAZONE A IS 7-ALCOXYCARBONYL-6,8-DIMETHYL-4- (A-CARBAMOYL-A-HALOGENOMETHYL) -1-PHTALAZONE, BY THE REACTION THEREOF WITH THIS CARBOXYLIC ACID SALT THEN HYDROLYSIS AND SIMULTANEOUS DECARBOXYLATION OF THE ACYLOXYL COMPOUND