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in water fast and strong quellende cyclodextrinpolymere, processes for their production and their use as desintegrationsmittel for tablet manufacture.
in water fast and strong quellende cyclodextrinpolymere, processes for their production and their use as desintegrationsmittel for tablet manufacture.
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机译:快速,强力的槲皮素环糊精聚合物的制备,制备方法及其在片剂生产中的崩解性。
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摘要
The invention relates to cyclodextrin polymers swelling quickly and to a great extent in water and a process for the preparation thereof. The cyclodextrin polymers according to the invention contain as additive n-octanol having or glycol derivative or glycerol. The cyclodextrin polymers according to the invention are prepared by reacting cyclodextrin and epichlorohydrin in aqueous alkaline medium. In the reaction the cyclodextrin is reacted with 10 to 20 moles of an alkali hydroxide, 10 to 20 moles of epichlorohydrin and 2 to 8 moles of an alcohol additive, n-octanol, glycol derivative or glycerol calculated on 1 mole of cyclodextrin optionally in the presence of 10 to 15 moles of an organic solvent vaporizing at the reaction temperature or 8 to 12 moles of a high boiling organic solvent assuring heterogeneous phase.
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