Mpl binding polypeptide mpl agonist polypeptide fragment polypeptide chimera antibody hybridoma cell line nucleic acid molecule DNA molecule expression vector host cell process of using a nucleic acid molecule method of determining the presence of polypeptide binding polypeptide mpl amplification method composition method for treating a mammal process for the biosynthesis of a human mpl binding polypeptide

摘要

Isolated mpl ligand, isolated DNA encoding mpl ligand, and recombinant methods of preparing mpl ligand are disclosed. These mpl ligands are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocyte progenitor cells. Accordingly, these compounds are used for treatment of thrombocytopenia.