POLYPEPTIDE OF MPL LIGAND (VARIANTS), ISOLATED MOLECUL OF NUCLEIC ACID ENCODING POLYPEPTIDE OF MPL LIGAND (VARIANTS), EXPRESSING VECTOR, HOST CELL, METHOD FOR MANUFACTURING POLYPEPTIDE OF MPL LIGAND (VARIANTS), COMPOSITION, METHOD FOR DRUG MANUFACTURING, METHOD FOR DETECTING POLYPEPTIDE OF MPL LIGAND, ANTIBODY, METHOD FOR PRODUCING ANTIBODY, HYBRIDOMA CELL LINE

摘要

Isolated thrombopoietin (TPO), isolated DNA encoding TPO, and recombinant or synthetic methods of preparing and purifying TPO are disclosed. Various forms of TPO are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocytes and megakaryocyte progenitor cells. Accordingly, these compounds may be used for treatment of thrombocytopenia.