Light chain, heavy chain, immunoglobulin or antigen binding fragment, humanized antibody or antigen binding fragment thereof, methods for preventing or treating amyloidogenic disease and alzheimer's disease in a patient, pharmaceutical composition, isolated polypeptide, variant of a polypeptide, isolated nucleic acid molecule, vector, host cell, method of producing an antibody, or fragment thereof, method of identifying residues leading to substitution in a humanized 3d6 immunoglobin variable backbone region, use of specified variable region tracking and isolated nucleic acid molecule

摘要

"LIGHT CHAIN, HEAVY CHAIN, IMMUNOGLOBULIN ORGANIZATION, ANTIGENE DISEASE, ANTIGENE CONNECTION FRAGMENT, HUMANIZED ANTIBODY OR ANTIGENE CONNECTION FRAGMENT polypeptide, Nucleic acid Isolated molecule, VECTOR, host cell, METHOD FOR PRODUCING AN ANTIBODY, OR EVEN THE SHRED, METHOD TO IDENTIFY waste leading to rEPLACEMENT IN A rEGION OF SKELETON vARIABLE IMMUNOGLOBULIN 3D6 humanized region sequence USE OF vARIABLE SPECIFIED , AND, NUCLEIC ACID MOLECULA ISOLATED ". The invention provides improved agents and methods for treating diseases associated with Aβ amyloid deposits in a patient's brain. Preferred agents include humanized antibodies.