Method for identifying a substance that alters the pigmentation in vertebrate epidermal melanocytes, a substance that inhibits, intensifies or modulates tyrosinase phosphorization mediated by c-beta kinase protein, use of an agent that modulates or inhibits phosphorization of a serine residue or of threonine mediated by the protein c-beta kinase, use in a peptide that specifically interferes with the phosphorization of residues of serine / threonine mediated by the protein c-beta kinase, use of a DNA or peptide construct to manufacture a drug to decrease pigmentation on the hair, hair, wool or hair of vertebrates and use of a substance that modulates tyrosinase phosphorization mediated by the protein c-beta kinase.

摘要

"METHOD FOR IDENTIFYING A SUBSTANCE THAT ALTERES PIGMENTATION IN VERTEBRATE EPIDERMAL MELANOCYTS, A SUBSTANCE THAT INHIBITS, INTENSIFIES OR MODULATES PHYROSINASE PHOSPHORIZATION BY THE PROTEIN OF A QUINAMINE THERAPY. OR TREONIN MEDIATED BY THE C-BETA KINASE PROTEIN, USE OF A PEPTIDE THAT SPECIFICALLY INTERFERES IN THE PHOSPHORIZATION OF SERINE WASTE / THREONEIN MEASURED BY THE C-BETA KINASE PROTEIN, USE OF A DNA BUILDING OR A PHEAPORINE FOR A PHARMACEUTICAL PIGMENTATION ON THE SKIN, HAIR, WOOL OR VERTEBRATE HAIR AND USE OF A SUBSTANCE THAT MODULATES THE PHYLOSINASE PHOSPHORIZATION MEDIATED BY THE C-BETA KINASE PROTEIN ", in which the skin, hair, wool or vertebrate hair may have a light color or darkened by the administration of a substance, for example, a peptide, antibody, antibody fragment or DNA sequence encoding a peptide o, which modulates tyrosinase activation mediated by the protein C-beta-kinase, the rate-limiting enzyme in melanogenesis.