Amide compounds, pharmaceutically acceptable salt of a pharmaceutically active metabolite of the compound, pharmaceutical composition to modulate or inhibit the activity of a protein kinase receptor, method of treating a disease of mammals mediated by protein kinase activity and method to modulate or inhibit the activity of a protein kinase receptor

摘要

"STARCH COMPOUNDS, PHARMACEUTICALLY ACCEPTABLE SALT FROM A PHARMACEUTICALLY ACTIVE METABOLITE IN THE COMPOUND, PHARMACEUTICAL COMPOSITION TO MODULATE OR INHIBIT THE ACTIVITY OF A PROTEIN KINASE RECEIVER, METHOD OF TREATMENT OF A METHOD OF STAINING INTO THE DISEASE. OR INHIBIT THE ACTIVITY OF A PROTEIN KINASE RECEPTOR ". These are amide compounds that modulate and / or inhibit the activity of certain protein kinases. These compounds and the pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and / or inhibit unwanted cell proliferation. The invention also relates to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and methods of treating cancer, as well as other unhealthy conditions associated with unwanted angiogenesis and / or cell proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.