A method of identifying a molecule and a protein involved in lipid regulation, testing a substance as a therapeutic agent for modulating lipid levels, treating lipid-mediated disorders and a patient suffering from a lipid-mediated condition, lipid levels in a host, to treat or prevent a lipid-mediated disorder, to treat or prevent atherosclerosis or a condition associated with atherosclerosis, to screen for diagnosis of a genetic predisposition to atherosclerosis or a condition associated with atherosclerosis or a lipid-mediated disorder, expressing hbm protein in tissue and modulating lipid levels in a patient, diagnostic assay to determine a predisposition to a lipid-mediated disorder, composition for treating a lipid-mediated condition, and, Combination therapy to treat a patient suffering from a disease or lipid-mediated condition

摘要

"METHODS OF IDENTIFYING A POLYCLE AND PROTEIN INVOLVED IN LIPID REGULATION, OF TESTING A SUBSTANCE AS A THERAPEUTIC AGENT FOR THE MODULATION OF LIPID LEVELS AND A LIPID-MEDIED PIPED REGULATED LIPID DIFFERENCE LIPID LEVELS IN A HOST, TO TREAT OR PREVENT A LIPID MEDIATED DISORDER, TO TREAT OR PREVENT ARTERIOSCLEROSIS OR A CONDITION ASSOCIATED WITH ARTERIOSCLEROSIS, TRIAL DIAGNOSIS WITH A HYDROGENOSIS WITH A HYDROGENOSIS ARTERIOSCLEROSIS OR A LIPID MEDIATED DISTURBUS, EXPRESSING HBM PROTEIN IN TISSUE AND MODULATING LIPID LEVELS IN A PATIENT, DIAGNOSTIC TEST TO DETERMINE A PREDISPOSITION FOR A MEDIUM PORDIUM DISTRIBUTION DIAGNOSIS , COMBINATION THERAPY TO TREAT A PATIENT SUFFERING FROM A DISEASE The or condition mediated by lipid. " The present invention relates to the high bone mass (HBM) gene, the corresponding wild type gene (Zmax1) and their mutants. The genes identified in the present invention are implicated in the regulation of physiological lipid levels and thus in lipid-mediated diseases and conditions. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in regulating lipid level in a patient. In preferred embodiments, the present invention is directed to methods for treating and preventing atherosclerosis, atherosclerotic cardiovascular disease, atherosclerotic and associated atherosclerotic conditions.