Tricyclic poly (adp-ribose) polymerase inhibitor compounds, their pharmaceutically acceptable salt, prodrug, active metabolite, or solvate, pharmaceutical composition, method of inhibiting parp activity of an enzyme and method of inhibiting parp enzyme activity in mammal tissue

摘要

"TRICYCLIC INHIBITORS OF POLY (ADP-RIBOSE) POLYMERASE, ITS PHARMACEUTICALLY ACCEPTABLE SALT, PRODUCT, ACTIVE METABOLIT, OR SOLVATOR, PHARMACEUTICAL COMPOSITION, METHOD OF INHIBITION OF ENHYDRATE ACTIVITIES ". The compounds of formula (I) are poly (ADP-ribosyl) transferase inhibitors. These compounds are useful as therapeutic agents in the treatment of cancers and in alleviating the effects of stroke, head trauma, and neurodegenerative disease.