首页>
外国专利>
Trypsin substrate, a diagnostic device, and use in assay for urinary trypsin inhibitor
Trypsin substrate, a diagnostic device, and use in assay for urinary trypsin inhibitor
展开▼
机译:胰蛋白酶底物,诊断装置以及用于尿胰蛋白酶抑制剂的测定
展开▼
页面导航
摘要
著录项
相似文献
摘要
Compounds of formula (I) are described wherein R1 is a protecting group for Ná, R2 is a protecting group for NG; and R3 is aryl, and wherein the compound of formula (I) is a trypsin substrate such that trypsin cleaves the O-C single bond, which liberates R3-OH. These compounds are used to produce visible colours in dry-phase analytical elements so as to detect quantities of urinary trypsin inhibitor (UTI) in a biological sample such as urine. The compounds of formula (I) provide aromatic esters of Ná (á amino group) and NG (guanidine group) bis-protected arginine that are trypsin substrates. The trypsin hydrolyses esters of arginine and protecting groups on the guanidine moiety.
展开▼