Processes for producing derivative of aspartyl dipeptu00ecdeo ester.To produce 3 - (3 - hydroxy - 4-methoxyphenyl) - 3 - metilbutilaldeu00ecdo and to produce n - n - 3 - (3 - hiidru00f3xi - 4-methoxyphenyl) 3 - metilbutil - L - alpha - aspartyl - L-phenylalanine 1-methyl ester,Derivative of benzene, crystal of N - n - 3 - (3 - hydroxy - 4 - metu00f3xifenil) - 3 - metilbutil - L - alpha - aspartyl - L-phenylalanine 1-methyl ester,A sweetener or a food and drink or other product with a sweet taste conferred, and the process to impart a sweet taste

摘要

"Processes to produce aspartyl dipeptu00ecdeo ester derivative.To produce 3 - (3 - hydroxy - 4metoxifenil) - 3 - metilbutilaldeu00ecdo and to produce n - [n - [3 - (3 - hydroxy - 4-methoxyphenyl) 3 - metilbutil] - L - alpha - ASP artil] - L - phenylalanine 1-methyl ester, derived from benzene.Crystal of N - [n - [3 - (3 - hydroxy - 4 - metu00f3xifenil) - 3 - metilbutil] - L - alpha - the partil] - L - phenylalanine 1-methyl ester, sweetener or a food and drink or other product with a sweet taste check, and.The process to impart a sweet taste "3 - (3 - hydroxy - 4-methoxyphenyl) - 3 - metilbutilaldeu00eddo is produced by a reaction, by which the carboxyl group in the acid, 3 - (3 - hydroxy - 4-methoxyphenyl) - 3 - metilbutu00edrico,Which can be obtained by the reaction of 2 - halogenoanisol with acid, 3 - metilcrotu00f3nico and becoming the atom of halogen in the thus produced acid, 3 - (3 - halogeno - 4-methoxyphenyl) - 3 - metilbutu00edrico in a GHydroxyl group is converted into a group formila.By a reductive alkylation reaction with aspartame.This derivative aldehyde can easily and efficiently be converted into an industrial scale in the N - [n - [3 - (3 - hydroxy - 4-methoxyphenyl) - 3 - metilbutil] - L - 244 - aspartyl] - L - fenilal Anina 1 - methyl ester.It is useful as a sweetener that has a high degree of sweetness. Thus, the aldehyde derivative is highly excellent as an intermediary for the production of sweetener.