Nucleotide and protein sequences of nogo genes and methods based thereon for treatment of diseases that result in damage to the central system

摘要

Described are the gene, Nogo, its encoded protein products, as well as derivatives and analogues thereof. Production of Nogo proteins, derivatives, and antibodies is also provided as are therapeutic compositions and methods of diagnosis and therapy for diseases, disorders or damage that ultimately result in damage of the nervous system; such diseases, disorders or damage include central nervous system (CNS) trauma, (e. g. spinal cord or brain injuries), infarction, infection, malignancy, exposure to toxic agents, nutritional deficiency, paraneoplastic syndromes, and degenerative nerve diseases (including but not limited to Alzheimer's disease, Parkinson's disease, Huntington's Chorea, multiple sclerosis, amyotrophic lateral sclerosis, and progressive supra-nuclear palsy); by administering compounds that interfere with Nogo activity (e. g., a dominant negative Nogo derivative; antibodies to Nogo; anti-sense nucleic acids of Nogo; Nogo ribozymes or chemical groups that bind an active site of Nogo).