Method of manufacturing T-20 and T-1249 peptides at commercial scale, and T-20 and T-1249 compositions related thereto

摘要

The present invention relates to an improved process for making commercial quantities of a T-20 or a T-1249 composition, or a fragment of a T-20 or a T-1249 composition. The improvement includes using a low void space resin and/or a surface functionalized resin optionally loaded with an amino acid or amino acid derivative to create one or more T-20 or T-1249 fragments.