首页> 外国专利> DERIVATIVES OF DIHIDRO BENZO (B) (1,4) DIACEPIN-2-ONA AS ANGLONISTS OF MGLUR2 II.

DERIVATIVES OF DIHIDRO BENZO (B) (1,4) DIACEPIN-2-ONA AS ANGLONISTS OF MGLUR2 II.

机译:Dihidro Benzo(B)(1,4)Diacepin-2-ona作为MGLUR2的英国人的衍生物II。

摘要

Compounds of ** formula ** wherein X is a single bond or an ethinediyl group; wherein in case X is a single bond, R1 is cyano, halogen, C1-C7 alkyl, C3-C6-cycloalkyl, C1-C7 alkoxy, fluoro-C1-C7 alkoxy, fluoro-C1-C7 alkyl, or is pyrrole -1-yl, which is not substituted or substituted by one to three substituents selected from the group consisting of fluoro, chloro, cyano, - (CH2) 1-4-hydroxyl, fluoro-C1-C7 alkyl, C1-C7 alkyl, - (CH2) n-C1-C7 alkoxy, - (CH2) nC (O) OR¿ ¿, - (CH2) 1-4-NR¿R¿¿, hydroxy-C1-C7 alkoxy and - (CH2) n- CONR¿R¿¿, or is it phenyl, which is not substituted or substituted by one or two substituents selected from the group consisting of halogen, alkyl 1, fluoro-alkyl 1, C1-C7 alkoxy, fluoro-C1-C7 alkoxy and cyano ; and to its pharmaceutically acceptable addition salts.
机译:式**的化合物,其中X为单键或乙二基;其中在X为单键的情况下,R 1为氰基,卤素,C 1 -C 7烷基,C 3 -C 6环烷基,C 1 -C 7烷氧基,氟-C 1 -C 7烷氧基,氟-C 1 -C 7烷基,或为吡咯-1 -未被取代或未被一至三个选自氟,氯,氰基,-(CH2)1-4-羟基,氟-C1-C7烷基,C1-C7烷基,-( CH2)n-C1-C7烷氧基,-(CH2)nC(O)OR¿-,-(CH2)1-4-NR¿R¿¿,羟基C1-C7烷氧基和-(CH2)n-CONR¿ R 6是未被取代或未被一个或两个选自卤素,烷基,氟代烷基1,氟代烷基1,C 1 -C 7烷氧基,氟代-C 1 -C 7烷氧基和氰基的取代基取代或取代的苯基;及其药学上可接受的加成盐。

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