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ANTI-IDIOTYPE ANTIBODY HAVING ANTIFUNGAL ACTIVITY ON FUNGUS CARRYING β-GLUCAN SYNTHASE AND UTILIZATION OF THE SAME

机译：对携带β-葡聚糖合酶的真菌具有抗真菌活性的抗独特型抗体及其利用

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摘要

By using a neutralizing antibody nmAb-KT against HM-1 killer toxin as an idiotype antigen, a single-chain Fv antibody is successfully obtained by the phage display method. It is confirmed that this antibody actually has an HM-1 killer toxin activity and exhibits an antifungal activity on a fungus carrying β-glucan synthase. This antibody can be used as an antifungal agent and is highly useful.

机译：通过使用针对HM-1杀手毒素的中和抗体nmAb-KT作为独特型抗原，通过噬菌体展示法成功获得了单链Fv抗体。证实了该抗体实际上具有HM-1杀伤毒素活性，并且对携带β-葡聚糖合酶的真菌表现出抗真菌活性。该抗体可用作抗真菌剂，非常有用。

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公开/公告号WO2006093071A1

专利类型
公开/公告日2006-09-08

原文格式PDF
申请/专利权人 GENECARE RESEARCH INSTITUTE CO. LTD.;FURUICHI YASUHIRO;KOMIYAMA TADAZUMI;
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申请/专利号WO2006JP303551
发明设计人 FURUICHI YASUHIRO;KOMIYAMA TADAZUMI;
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申请日2006-02-27
分类号C12N15/09;A61K38;A61K39/395;A61P31/10;C07K16/42;C07K19;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/02;C12P21/08;
国家 WO
入库时间 2022-08-21 21:29:30

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