The diagnosis of use in TGF-B3 gene mutant of Nonsyndromic cleft lip and palate

摘要

the invention of the mutant gene TGF-B3 with cleft lip and palate disorders of the diagnostic method of the present invention that Korean mutations in the gene of the contents of TGF-B3 did not known so far , Korean is a variation on the specific gene sequences. Cleft lip and palate patients compared to normal tissues and in normal tissues was found that mutations in the TGF-B3 found a mutation expressed in the same position in cleft lip and palate patient organizations TGF-B3 gene mutation found to grow because the cause of cleft lip and palate , may be used to diagnose diseases Cleft sweep through these TGF-B3 gene mutation method . The invention also relates to an efficient method of diagnosing Cleft stamp .