首页> 外国专利> Noncommunicable HUMAN adenovirus as a vector for replacement GENE THERAPY angiogenesis disorder, provides an efficient synthesis of human angiogenin in transfected mammalian cells, a method of inducing angiogenesis, METHOD OF TREATMENT ischemic disease, composition for inducing angiogenesis and treatment of ischemic illness

Noncommunicable HUMAN adenovirus as a vector for replacement GENE THERAPY angiogenesis disorder, provides an efficient synthesis of human angiogenin in transfected mammalian cells, a method of inducing angiogenesis, METHOD OF TREATMENT ischemic disease, composition for inducing angiogenesis and treatment of ischemic illness

机译:非传染性人类腺病毒作为替代基因治疗血管生成障碍的载体,可在转染的哺乳动物细胞中有效合成人血管生成素,诱导血管生成的方法,治疗缺血性疾病的方法,诱导血管生成的组合物和治疗缺血性疾病的方法

摘要

1. u043du0435u0438u043du0444u0435u043au0446u0438u043eu043du043du044bu0439 u0434u043bu00a0 human adenovirus as vector to gene therapy of u0434u043bu00a0 u0430u043du0433u0438u043eu0433u0435u043du0435u0437u0430 (for example with u0430u0434u0435u043du043eu0432u0438u0440u0443u0441u0430 birds CELO and gene and, u043au043eu0434u0438u0440u0443u044eu0449u0435u0433u043e angiogenin rights) with the following properties:;- u00a0u0432u043bu00a0u0435u0442u0441u00a0 u0440u0435u043fu043bu0438u043au0430u0442u0438u0432u043du043e - defective cells in mammals (u0432u043au043bu044eu0447u0430u00a0 rights);;in the field, a minor u0434u043bu00a0 replication in the cells of the birds, is u044du043au0441u043fu0440u0435u0441u0441u0438u043eu043du043du0443u044e tape, u0441u043eu0441u0442u043eu00a0u0449u0443u044e of cmv promoter or gene, u043au0434u043du043a u0430u043du0433u0438u043eu0433u0435u043du0438u043du0430 rights and the signal u043fu043eu043bu0438u0430u0434u0435u043du0438u043bu0438u0440u043eu0432u0430u043du0438u00a0 ox growth hormone;;provides u0430u043du0433u0438u043eu0433u0435u043du0435u0437u0430 induction.;2. method of induction u0430u043du0433u0438u043eu0433u0435u043du0435u0437u0430, comprising a body of a mammal u0430u043du0433u0438u043eu0433u0435u043du0435u0437u0430 u043eu0442u043bu0438u0447u0430u044eu0449u0438u0439u0441u00a0 induction factor, however, that, as such, use re u043au043eu043cu0431u0438u043du0430u043du0442u043du044bu0439 adenovirus on 1, constructed on the basis of both u043du0435u0438u043du0444u0435u043au0446u0438u043eu043du043du043eu0433u043e u0430u0434u0435u043du043eu0432u0438u0440u0443u0441u0430 birds, in an effective amount.;3. method u043bu0435u0447u0435u043du0438u00a0 coronary heart disease, including the system factor induction u0430u043du0433u0438u043eu0433u0435u043du0435u0437u0430, u043eu0442u043bu0438u0447u0430u044eu0449u0438u0439u0441u00a0, as such use u0440u0435u043au043eu043cu0431u0438u043du0430u043d u0442u043du044bu0439 adenovirus birds at 1 in an effective amount.;4. u043au043eu043cu043fu043eu0437u0438u0446u0438u00a0 u0434u043bu00a0 induction u0430u043du0433u0438u043eu0433u0435u043du0435u0437u0430 and u043bu0435u0447u0435u043du0438u00a0 coronary heart disease, u0432u043au043bu044eu0447u0430u044eu0449u0430u00a0 factor induction u0430u043du0433u0438u043eu0433u0435u043du0435u0437u0430 and physiologically acceptable solvent, u043eu0442u043bu0438u0447u0430u044eu0449u0430u00a0 u0441u00a0 because as a factor in the induction u0430u043du0433u0438u043eu0433u0435u043du0435u0437u0430 contains a recombinant adenovirus birds at 1 in an effective amount.
机译:1. u043d u0435 u0438 u043d u0444 u0435 u043a u0446 u0438 u043e u043d u043d u044b u0439 u0434 u043b u00a0人类腺病毒作为 u0434 u043b u00a0基因治疗的载体 u0430 u043d u0433 u0438 u043e u0433 u0435 u043d u0435 u0437 u0430(例如 u0430 u0434 u0435 u043d u043e u0432 u0438 u0440 u0443 u0441 u0430鸟CELO和基因,以及具有以下属性的 u043a u043e u0434 u0438 u0440 u0443 u044e u0449 u0435 u0433 u043e血管生成素权利);;-- u00a0 u0432 u043b u00a0 u0435 u0442 u0441 u00a0 u0440 u0435 u043f u043b u0438 u043a u0430 u0442 u0438 u0432 u043d u043e-哺乳动物中的缺陷细胞( u0432 u043a u043b u043b u044e u0447 u0430 u00a0权利);在田野中,鸟类细胞中的 u0434 u043b u00a0较小复制是 u044d u043a u0441 u043f u0440 u0435 u0441 u0441 u0438 u043e u043d u043d u043d u0443 u044e ,cmv启动子或基因的 u0441 u043e u0441 u0442 u043e u00a0 u0449 u0443 u044e, u043a u0434 u043d u043a u0430 u043d u0433 u0438 u043e u0433 u0435 u043d u0438 u043d u0430权利和信号 u043f u043e u043b u0438 u0430 u0434 u0434 u0435 u043d u0438 u043b u0438 u0440 u04340 u043e u0432 u0430 u043d u043d u0438 u00a0 ox生长激素;提供 u0430 u043d u0433 u0438 u043e u0433 u0435 u043d u0435 u0437 u0430归纳; 2。诱导方法 u0430 u043d u0433 u0438 u043e u0433 u0435 u043d u0435 u0437 u0430,包括哺乳动物的身体 u0430 u043d u0433 u0438 u043e u0433 u0435 u0435 u043d u0435 u0437 u0430 u043e u0442 u043b u0438 u0447 u0430 u044e u0449 u0438 u0439 u0441 u00a0归纳因子,因此,请使用 u043a u043e u043c u043c u0431 u0438 u043d u0430 u043d u0442 u043d u044b u0439腺病毒1,是基于 u043d u0435 u0438 u043d u0444 u0435 u043a u0446 u0438 u043e u043e u043d u043d u043e u0433 u043e u0430 u0434 u0435 u043d u043e u0432 u0438 u0440 u0443 u0441 u0430鸟,有效量; 3。方法 u043b u0435 u0447 u0435 u043d u0438 u00a0冠心病,包括系统因子诱导 u0430 u043d u0433 u0438 u043e u0433 u0435 u043d u0435 u0437 u0430, u043e u0442 u043b u0438 u0447 u0430 u044e u0449 u0438 u0439 u0441 u00a0,因此请使用 u0440 u0435 u043a u043e u043c u0431 u0438 u043d u0430 u043d u0442 u0431有效剂量为1的腺病毒禽类; 4。 u043a u043e u043c u043f u043e u0437 u0438 u0446 u0438 u00a0 u0434 u043b u00a0感应 u0430 u043d u0433 u0438 u043e u043e u0433 u0435 u043d u0435 u0437和 u043b u0435 u0447 u0435 u043d u0438 u00a0冠心病, u0432 u043a u043b u044e u0447 u0430 u044e u0449 u0430 u00a0因素诱导 u0430 u043d u0433 u0438 u043e u0433 u0435 u043d u0435 u0437 u0430和生理上可接受的溶剂 u043e u0442 u043b u0438 u0447 u0430 u044e u0449 u0430 u00a0 u0441 u00a0是因为诱导中的因素 u043d u0433 u0438 u043e u0433 u0435 u043d u0435 u0437 u0430包含有效量为1的重组腺病毒鸟。

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