NON-INFECTIOUS FOR HUMAN ADENOVIRUS AS VECTOR FOR SUBSTITUTION GENETIC THERAPY OF ANGIOGENESIS DISORDER PROVIDING EFFECTIVE SYNTHESIS OF HUMAN ANGIOGENIN IN MAMMALIAN TRANSFECTED CELLS, METHOD FOR ANGIOGENESIS INDUCTION, METHOD FOR TREATMENT OF ISCHEMIC DISEASE, COMPOSITION FOR INDUCTION OF ANGIOGENESIS AND TREATMENT OF ISCHEMIC DISEASE

摘要

FIELD: medicine, biotechnology, genetic engineering.;SUBSTANCE: invention proposes non-infectious for human adenovirus as a vector for substitution genetic therapy of angiogenesis disorders. This adenovirus is replicative-defect in mammalian cells (including humans) in region that is not essential for replication in avian cells and carries expression cassette consisting of cytomegalovirus promoter, human angiogenin gene cDNA and polyadenylation signal of bovine hormone growth, and provides induction of angiogenesis. Invention proposes a method for induction of angiogenesis and method for treatment of ischemic disease by using a composition comprising the proposed recombinant adenovirus. Invention can be used in medicine in treatment of cardiovascular diseases.;EFFECT: valuable medicinal properties of adenovirus and composition.;5 cl, 1 dwg, 4 ex