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Piperidine-2,6-dion- pamoate salts and their use for the treatment of stress-related affective disorders
Piperidine-2,6-dion- pamoate salts and their use for the treatment of stress-related affective disorders
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机译:哌啶2,6-二氢棕榈酸酯盐及其在与压力有关的情感障碍的治疗中的应用
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摘要
Novel pamoate salts of certain 3-phenyl-3-dimethylaminoalkyl-4,4-dimethylpiperidin-2,6-diones and pharmacologically acceptable solvates thereof are devoid of the weight loss and hepatocyte changes in the rat which limited to marginally effective levels the permitted clinical doses of the corresponding hydrochlorides in the treatment or prophylaxis of stress-related affective disorders such as anxiety, depression, migraine and sleep apnoea. The preferred pamoate salts are 3(3,5-dimethoxyphenyl)-3-(3-dimethylaminopropyl)-4,4-dimethylpiperidine-2,6-dione pamoate and, especially, 3(3-methoxyphenyl)-3-(3-dimethylaminopropyl)-4,4-dimethylpiperidine-2,6-dione pamoate.
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