首页> 外国专利> METHODS, KITS AND ARRAYS FOR SCREENING FOR, PREDICTING AND IDENTIFYING DONORS FOR HEMATOPOIETIC CELL TRANSPLANTATION, AND PREDICTING RISK OF HEMATOPOIETIC CELL TRANSPLANT (HCT) TO INDUCE GRAFT VS. HOST DISEASE (GVHD)

METHODS, KITS AND ARRAYS FOR SCREENING FOR, PREDICTING AND IDENTIFYING DONORS FOR HEMATOPOIETIC CELL TRANSPLANTATION, AND PREDICTING RISK OF HEMATOPOIETIC CELL TRANSPLANT (HCT) TO INDUCE GRAFT VS. HOST DISEASE (GVHD)

机译:筛选,鉴定和鉴定造血细胞移植供体的方法,试剂盒和阵列,以及预测造血细胞移植(HCT)诱发移植物VS的风险。主机疾病(GVHD)

摘要

The invention relates to predicting or determining risk of a hematopoietic cell transplant (HCT) from a donor to induce Graft vs. Host Disease (GVHD) in a HCT recipient; to classifying HCT from a candidate donor according to the risk of inducing GVHD in a HCT recipient; and to organizational constructs (e.g., databases) and methods of producing organizational constructs (e.g., databases) in which HCT of one or more candidate donors is classified or scored according to risk of inducing GVHD in a HCT recipient. The invention also relates to kits and arrays useful for predicting or determining risk of HCT from a candidate donor to induce GVHD in a HCT recipient, and for classifying or scoring such donors according to risk of inducing GVHD in a HCT recipient.
机译:本发明涉及预测或确定来自供体的造血细胞移植(HCT)在HCT接受者中诱发移植物抗宿主病(GVHD)的风险;根据在HCT接受者中诱发GVHD的风险对候选供者的HCT进行分类;以及组织结构(例如数据库)和产生组织结构(例如数据库)的方法,其中根据在HCT接受者中诱导GVHD的风险对一个或多个候选供体的HCT进行分类或评分。本发明还涉及试剂盒和阵列,其可用于预测或确定来自候选供体的HCT的风险以诱导HCT接受者中的GVHD,并用于根据在HCT接受者中诱导GVHD的风险来对此类供体进行分类或评分。

著录项

  • 公开/公告号EP2633083A2

    专利类型

  • 公开/公告日2013-09-04

    原文格式PDF

  • 申请/专利权人 PBD BIODIAGNOSTICS LLC;

    申请/专利号EP20110837268

  • 发明设计人 GRELLER LARRY DAVID;SOMOGYI ROLAND;

    申请日2011-12-22

  • 分类号C12Q1/68;G01N33/53;C12P19/34;

  • 国家 EP

  • 入库时间 2022-08-21 16:28:59

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