COMPLEXATION METHODS WITH CYCLODEXTRINS FOR THE INTRODUCTION OF PEPTIDE PROTEASOMIC INHIBITORS INTO PHARMACEUTICAL COMPOSITIONS

摘要

This invention relates to methods for formulating compositions containing one or more peptide proteasome inhibitors and cyclodextrin, in particular a substituted cyclodextrin. Such methods significantly increase the solubility and stability of these proteasome inhibitors and facilitate both their manufacture and their administration.