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MICRO AND NANO SCALE STRUCTURES DISPOSED IN A MATERIAL SO AS TO PRESENT MICROMETER AND NANOMETER SCALE CURVATURE AND STIFFNESS PATTERNS FOR USE IN CELL AND TISSUE CULTURING AND IN OTHER SURFACE AND INTERFACE APPLICATIONS
MICRO AND NANO SCALE STRUCTURES DISPOSED IN A MATERIAL SO AS TO PRESENT MICROMETER AND NANOMETER SCALE CURVATURE AND STIFFNESS PATTERNS FOR USE IN CELL AND TISSUE CULTURING AND IN OTHER SURFACE AND INTERFACE APPLICATIONS
A structure for use in cell and tissue culturing and in other surface and interface applications. The structure comprises a first material layer defining one or more surface features therein disposed randomly or in a pattern, the one or more surface features having the same or different sizes and cross sectional shapes, a second material layer disposed in or on the one or more surface features, a microstructure disposed in or on the one or more surface features and at least partially embedded and immobile within the second material layer, the microstructure presenting a curvature and a stiffness value and protruding above an upper surface of the second material, a size of the microstructure between 1 nanometer and 10 millimeters, and the structure for use in cell and tissue culturing and in other surface and interface applications wherein a cell grows on the microstructure.
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