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Methods for determining hypersusceptibility of HIV-1 to non-nucleoside reverse transcriptase inhibitors
Methods for determining hypersusceptibility of HIV-1 to non-nucleoside reverse transcriptase inhibitors
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机译:确定HIV-1对非核苷类逆转录酶抑制剂的高度敏感性的方法
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摘要
This invention relates to methods for determining hypersusceptibility of HIV-1 viruses to non-nucleoside reverse transcriptase inhibitors (NNRTIs) based on the viral genotypes. The methods generally comprise detecting, in a gene encoding reverse transcriptase of the HIV-1, the presence of a mutation at codon 65, 69, or 74 alone or in combination with one or more mutations at certain other codons. Combinations of mutations associated with hypersusceptibility to NNRTIs are also disclosed.
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