processes for preparing form 1 of obeticolic acid and crystalline obeticolic acid

摘要

The present invention relates to obeticolic acid: or a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. obeticolic acid is useful for treating or preventing an fxr, cardiovascular or cholestatic liver disease mediated disease or condition, and for reducing hdl cholesterol, for reducing triglycerides in a mammal, or for inhibiting fibrosis . The present invention also relates to processes for the synthesis of obeticolic acid.