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Method for predicting the effect of tumor immunotherapy using tumor cell cytotoxicity of peripheral blood T cells as an index

机译:以外周血T细胞的肿瘤细胞毒性为指标预测肿瘤免疫治疗效果的方法

摘要

An object of the present invention is to provide a companion diagnosis for predicting the effect of tumor immunotherapy. Step 1 of directly or indirectly contacting a peripheral blood mononuclear cell collected from a patient to be treated for a malignant tumor with a tumor cell in vitro, and the tumor cell contacted with the peripheral blood mononuclear cell in the step 1 Step 2 of determining whether or not the patient has been injured, and when it is determined in Step 2 that the tumor cells are injured, the tumor immunotherapy is effective for the malignant tumor of the patient The effect of the tumor immunotherapy is predicted by the method including the step of determining 3.
机译:本发明的目的是提供用于预测肿瘤免疫疗法的效果的伴随诊断。步骤1:使从待治疗恶性肿瘤患者中采集的外周血单核细胞与肿瘤细胞直接或间接接触,然后在步骤1中使肿瘤细胞与外周血单核细胞接触。病人是否受伤,并且在步骤2中确定肿瘤细胞受伤时,肿瘤免疫疗法对患者的恶性肿瘤有效。肿瘤免疫疗法的效果可通过以下步骤预测:确定3。

著录项

  • 公开/公告号JPWO2019004415A1

    专利类型

  • 公开/公告日2020-03-19

    原文格式PDF

  • 申请/专利权人 国立大学法人大阪大学;

    申请/专利号JP20190527052

  • 发明设计人 岩堀 幸太;和田 尚;

    申请日2018-06-29

  • 分类号C12Q1/02;C12M1/34;

  • 国家 JP

  • 入库时间 2022-08-21 11:32:01

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