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阿片类药物质分子用于治疗干眼症和患有过敏症眼睛的用途

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摘要

本发明涉及能够调节CFTR和抑制嗜碱性粒细胞和肥大细胞脱粒的阿片类药物分子，(3S)‑6,7‑二甲氧基‑3‑[(5R)‑4‑甲氧基‑6‑甲基‑7,8‑二氢‑5H‑[1,3]二氧杂环戊并[4,5‑g]异喹啉‑5‑基]‑3H‑2‑苯并呋喃‑1‑酮的左旋和右旋对映异构体，在治疗干眼症和患有过敏症的眼睛上的用途。

著录项

公开/公告号CN114096248A

专利类型发明专利
公开/公告日2022-02-25

原文格式PDF
申请/专利权人 H4奥芬制药;加埃唐·泰拉斯;
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申请/专利号CN202080049514.X
发明设计人加埃唐·泰拉斯;凯瑟琳·伯尔;
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申请日2020-06-05
分类号A61K31/4741(20060101);A61K31/78(20060101);A61K31/728(20060101);A61P27/02(20060101);A61P37/08(20060101);
代理机构31220 上海旭诚知识产权代理有限公司;
代理人郑立;周素霞
地址法国第戎
入库时间 2023-06-19 14:15:58

法律信息

法律状态公告日

法律状态信息

法律状态
2022-06-24

实质审查的生效 IPC(主分类):A61K31/4741 专利申请号:202080049514X 申请日:20200605

实质审查的生效

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1. 阿片类药物质分子用于治疗干眼症和患有过敏症眼睛的用途 [P] . 中国专利： CN114096248A . 2022-02-25
2. 物质治疗患有青光眼和其它退化性眼部疾病的人的视力丧失的用途 [P] . 中国专利： CN101743015A . 2010-06-16
3. pharmaceutical composition, use of an aromatic alcohol together with a biguanide or a pharmaceutically acceptable salt thereof, methods for enhancing the absorption of a macromolecular active ingredient in a patient and for treating a patient suffering from a condition or disease, and uses of a macromolecular active ingredient and a biguanide or a pharmaceutically acceptable salt thereof, a macromolecular active ingredient, an aromatic alcohol absorption enhancer and a biguanide or a pharmaceutically acceptable salt thereof and calcitonin, an aromatic alcohol absorption enhancer and a biguanide or a pharmaceutically acceptable salt thereof [P] . BRPI0707866A2 . 2011-05-10

机译：药物组合物，芳族醇与双胍或其药学上可接受的盐一起的用途，用于增强患者体内大分子活性成分吸收和治疗患有疾病或疾病的患者的方法以及大分子活性物质的用途成分和双胍或其可药用盐，大分子活性成分，芳香醇吸收促进剂和双胍或其可药用盐和降钙素，芳香醇吸收增强剂和双胍或其可药用盐
4. A method of identifying a molecule and a protein involved in lipid regulation, testing a substance as a therapeutic agent for modulating lipid levels, treating lipid-mediated disorders and a patient suffering from a lipid-mediated condition, lipid levels in a host, to treat or prevent a lipid-mediated disorder, to treat or prevent atherosclerosis or a condition associated with atherosclerosis, to screen for diagnosis of a genetic predisposition to atherosclerosis or a condition associated with atherosclerosis or a lipid-mediated disorder, expressing hbm protein in tissue and modulating lipid levels in a patient, diagnostic assay to determine a predisposition to a lipid-mediated disorder, composition for treating a lipid-mediated condition, and, Combination therapy to treat a patient suffering from a disease or lipid-mediated condition [P] . BR0111057A . 2003-04-15

机译：一种鉴定参与脂质调节的分子和蛋白质的方法，测试一种物质作为调节脂质水平的治疗剂，治疗脂质介导的疾病和患有脂质介导的疾病的患者，治疗宿主的脂质水平或预防脂质介导的疾病，治疗或预防动脉粥样硬化或与动脉粥样硬化有关的疾病，筛选诊断动脉粥样硬化的遗传易感性或与动脉粥样硬化或脂质介导的疾病有关的疾病，在组织中表达hbm蛋白并调节患者中的脂质水平，确定脂质介导疾病易感性的诊断测定法，用于治疗脂质介导疾病的组合物以及用于治疗患有疾病或脂质介导疾病的患者的联合疗法
5. methods for screening for a therapeutic agent, for suppressing the polynucleotide sequence, for treating a non-steroidal cancer, for screening for binding of an agent specifically to a polynucleotide, and for determining whether a patient is at risk for developing or having a non-steroidal cancer, pharmaceutical composition, uses of a therapeutic agent, an antisense molecule or a cell that expresses and / or contains the antisense molecule, at least one of the immunogenic membrane proteins, fragments, derivatives or homologues thereof or from a cell containing and / or expressing at least one of the immunogenic membrane proteins or fragments, derivatives or homologues thereof and an agent or antibody, agent, and kit for identifying a patient at risk of developing or have non-steroidal cancer [P] . BRPI0414446A . 2006-11-14

机译：筛选治疗剂，抑制多核苷酸序列，治疗非甾体类癌症，筛选试剂特异性结合多核苷酸的方法以及确定患者是否处于发展或患有非糖尿病风险的方法类固醇癌，药物组合物，表达和/或含有反义分子的治疗剂，反义分子或细胞，免疫原性膜蛋白，其片段，衍生物或同源物中至少一种或来自含有和/或含有细胞的细胞的用途或表达至少一种免疫原性膜蛋白或其片段，衍生物或同系物以及一种试剂或抗体，试剂和试剂盒，用于鉴定有发生或患有非甾体癌风险的患者