腺相关病毒载体用于在内耳中的毛细胞和支持细胞中校正基因缺陷/表达蛋白质的用途

摘要

本文提供了包含至少两种不同的核酸载体的组合物，所述至少两种不同的载体，当被引入到灵长类动物细胞中时，经历彼此串联或同源重组，从而形成编码全长靶蛋白(例如，支持细胞靶蛋白或毛细胞靶蛋白)的重组核酸。还提供了包含单一AAV载体的组合物，所述单一AAV载体，当被引入到灵长类动物细胞中时，在支持细胞靶基因的基因座处产生了编码全长靶蛋白(例如，支持细胞靶蛋白或毛细胞靶蛋白)的核酸，并且所述灵长类动物表达靶蛋白(例如，支持细胞靶蛋白或毛细胞靶蛋白)。

说明书

相关申请的交叉引用

本申请要求2018年11月7日提交的的序列号为62/756,953的美国临时专利申请和2019年8月16日提交的序列号为62/888,093的美国临时专利申请的优先权，所述申请的全部内容通过引用并入本文。

技术领域

本公开总体上涉及核酸治疗灵长类动物的听力损失的用途。

发明背景

听力损失可以是传导性的(从耳道或中耳引起的)、感音神经性的(从内耳或听觉神经引起)或混合性的。大多数形式的非综合征性耳聋都与内耳结构受损引起的永久性听力损失(感音神经性耳聋)相关联，尽管一些形式可能涉及中耳的变化(传导性听力损失)。人的大部分感音神经性听力损失是由耳蜗中Corti器的毛细胞异常(毛细胞功能差)引起的。毛细胞在出生时可能是异常的，或者在个体的一生中可能会受到损害(例如，由于噪音创伤或感染所致)。

发明内容

本发明基于以下发现：包含至少两种不同的核酸载体的组合物，其中：所述至少两种不同的腺相关病毒(AAV)载体中的每一种均包含编码序列，所述编码序列编码支持细胞靶蛋白的不同部分，所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分中的每一个的氨基酸序列可以任选地与所述编码的部分中的不同的一个部分的氨基酸序列部分地重叠；所述至少两种不同的载体中单一载体均不编码全长支持细胞靶蛋白；所述编码序列中的至少一个包含跨越支持细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述两个相邻外显子之间缺乏内含子序列；以及所述至少两种不同的载体，当被引入到灵长类动物细胞中时，经历彼此串联或同源重组，从而形成编码全长支持细胞靶蛋白的重组核酸。

本文提供了包含至少两种不同的核酸载体的组合物，其中：所述至少两种不同的腺相关病毒(AAV)载体中的每一种均包含编码序列，所述编码序列编码支持细胞靶蛋白的不同部分，所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分中的每一个的氨基酸序列可以任选地与所述编码的部分中的不同的一个部分的氨基酸序列部分地重叠；所述至少两种不同的载体中单一载体均不编码全长支持细胞靶蛋白；所述编码序列中的至少一个包含跨越支持细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述两个相邻外显子之间缺乏内含子序列；以及所述至少两种不同的载体，当被引入到灵长类动物细胞中时，经历彼此串联或同源重组，从而形成编码全长支持细胞靶蛋白的重组核酸。

在本文所述的任何组合物的一些实施方案中，所述编码的部分之一的氨基酸序列与所述编码的部分中的不同的一个部分的氨基酸序列重叠。在本文所述的任何组合物的一些实施方案中，所述编码的部分中的每一个的氨基酸序列与不同的编码的部分的氨基酸序列部分地重叠。在本文所述的任何组合物的一些实施方案中，重叠氨基酸序列的长度为30个氨基酸残基至约390个氨基酸残基。

在本文所述的任何组合物的一些实施方案中，所述至少两种不同的载体中的每一种包含内含子的不同区段，其中所述内含子包含存在于支持细胞靶基因组DNA中的内含子的核苷酸序列，并且其中两个不同的区段在序列上重叠至少100个核苷酸。在本文所述的任何组合物的一些实施方案中，所述两个不同的区段在序列上重叠约30个核苷酸至约390个核苷酸。在本文所述的任何组合物的一些实施方案中，所述至少两种不同的载体中的每一种的核苷酸序列的长度为约30个核苷酸至约390个核苷酸。在本文所述的任何组合物的一些实施方案中，所述至少两种不同的载体中的每一种的核苷酸序列的长度为30个核苷酸至340个核苷酸。

在本文所述的任何组合物的一些实施方案中，所述组合物中不同载体的数目为2。在本文所述的任何组合物的一些实施方案中，所述两种不同的载体中的第一载体包含编码所述支持细胞靶蛋白的N末端部分的编码序列。在本文描述的任何组合物的一些实施方案中，支持细胞靶蛋白的N-末端部分的长度为约30个氨基酸至约390个氨基酸。在本文描述的任何组合物的一些实施方案中，支持细胞靶蛋白的N-末端部分的长度为约30个氨基酸至约340个氨基酸。在本文所述的任何组合物的一些实施方案中，第一载体还包含启动子和Kozak序列之一者或两者。在本文所述的任何组合物的一些实施方案中，第一载体包含启动子，所述启动子为诱导型启动子、组成型启动子或组织特异性启动子。

在本文所述的任何组合物的一些实施方案中，两种不同的载体中的第二载体包含编码支持细胞靶蛋白的C末端部分的编码序列。在本文描述的任何组合物的一些实施方案中，支持细胞靶蛋白的C-末端部分的长度为约30个氨基酸至约390个氨基酸。在本文描述的任何组合物的一些实施方案中，支持细胞靶蛋白的C-末端部分的长度为约30个氨基酸至约340个氨基酸。在本文所述的任何组合物的一些实施方案中，第二载体还包含poly(dA)序列。

本文还提供了包含两种不同的核酸载体的组合物，其中：所述两种不同的核酸载体中的第一核酸载体包含启动子、位于所述启动子的3’的编码支持细胞靶蛋白的N末端部分的第一编码序列和位于所述第一编码序列的3’末端的剪接供体信号序列；以及所述两种不同的核酸载体中的第二核酸载体包含剪接受体信号序列、位于所述剪接受体信号序列的3'末端的编码支持细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多聚腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的氨基酸序列不重叠，其中所述两种不同的载体中单一载体均不编码所述全长支持细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长支持细胞靶蛋白的重组RNA分子。

在本文所述的任何组合物的一些实施方案中，所述编码序列中的至少一个包含跨越支持细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在相邻外显子之间缺乏内含子序列。

本文还提供了组合物，其包含：第一核酸载体，其包含启动子、位于所述启动子的3'的编码支持细胞靶蛋白的N末端部分的第一编码序列、位于所述第一编码序列的3’末端的剪接供体信号序列，和位于所述剪接供体信号序列的3’的第一可检测标记基因；以及第二核酸载体，其与所述第一核酸载体不同，包含第二可检测标记基因、位于所述第二可检测标记基因的3’的剪接受体信号序列、位于所述剪接受体信号序列的3’末端的编码支持细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的各自的氨基酸序列彼此不重叠，其中所述两种不同的载体中单一载体均不编码所述全长支持细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长支持细胞靶蛋白的重组RNA分子。

在本文所述的任何组合物的一些实施方案中，所述编码序列中的至少一个包含跨越支持细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在相邻外显子之间缺乏内含子序列。在本文所述的任何组合物的一些实施方案中，所述第一可检测标记基因或所述第二可检测标记基因是碱性磷酸酶。在本文所述的任何组合物的一些实施方案中，所述第一可检测标记基因和所述第二可检测标记基因是相同的。

本文还提供了组合物，其包含：第一核酸载体，其包含启动子、位于所述启动子的3'的编码支持细胞靶蛋白的N末端部分的第一编码序列、位于所述第一编码序列的3’末端的剪接供体信号序列，和位于所述剪接供体信号序列的3’的F1噬菌体重组发生区；和第二核酸载体，其与所述第一核酸载体不同，包含第二F1噬菌体重组发生区、位于所述第二F1噬菌体重组发生区的3’的剪接受体信号序列、位于所述剪接受体信号序列的3’末端的编码支持细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的各自的氨基酸序列彼此不重叠，其中所述两种不同的载体中单一载体均不编码所述全长支持细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长支持细胞靶蛋白的重组RNA分子。

在本文所述的任何组合物的一些实施方案中，所述编码序列中的至少一个包含跨越支持细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述两个相邻外显子之间缺乏内含子序列。

本文还提供了包含单一腺相关病毒(AAV)载体的组合物，其中所述单一AAV载体包含编码支持细胞靶蛋白的核酸序列；以及当被引入到灵长类动物细胞中时，在支持细胞靶基因的基因座处产生编码全长支持细胞靶蛋白的核酸，并且所述灵长类动物表达所述支持细胞靶蛋白。

在本文所述的任何组合物的一些实施方案中，所述支持细胞靶基因是缝隙连接蛋白β2(GJB2)。在本文所述的任何组合物的一些实施方案中，所述支持细胞靶基因是溶质运载蛋白家族26成员4(SLC26A4)。

在本文所述的任何组合物的一些实施方案中，所述组合物还包含药学上可接受的赋形剂。

在本文所述的任何组合物的一些实施方案中，第二核酸载体还包含失稳序列。

在本文所述的任何组合物的一些实施方案中，第二核酸载体还包含FKBP12失稳序列。

本文还提供了包括本文所述的任何组合物的试剂盒。在本文所述的任何试剂盒的一些实施方案中，试剂盒还包括包含所述组合物的预装式注射器。

本文还提供了校正灵长类动物内耳的支持细胞中的支持细胞靶基因缺陷的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物，其中所述施用修复所述灵长类动物内耳的支持细胞中的支持细胞靶基因缺陷。

本文还提供了升高灵长类动物内耳的支持细胞中的支持细胞靶蛋白的表达水平的方法，所述方法包括向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物，其中所述施用使得所述灵长类动物内耳的支持细胞中的所述支持细胞靶蛋白的表达水平升高。

在本文所述的任何方法的一些实施方案中，所述灵长类动物先前已被确定具有缺陷型支持细胞靶基因。

本文还提供了治疗被鉴定为具有缺陷型支持细胞靶基因的灵长类动物的非综合征性感音神经性听力损失的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物。

在本文所述的任何方法的一些实施方案中，所述方法还包括在施用步骤之前，确定灵长类动物具有缺陷型毛细胞靶基因。

本文还提供了恢复被鉴定或诊断为患有听力损失的灵长类动物的听力的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的如本文所述的任何组合物。

在本文所述的任何方法的一些实施方案中，所述方法还包括在施用步骤之前，确定灵长类动物具有缺陷型支持细胞靶基因。

本文还提供了恢复被鉴定或诊断为患有内耳病症的灵长类动物的突触并且/或者保留其螺旋神经节神经的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物。

在本文所述的任何方法的一些实施方案中，所述方法还包括在施用步骤之前，确定灵长类动物具有缺陷型支持细胞靶基因。

本文还提供了包括向灵长类动物的内耳施用治疗有效量的本文所述的任何组合物的方法。

在本文所述的任何方法的一些实施方案中，所述灵长类动物先前已被鉴定为具有缺陷型支持细胞靶基因。

本文还提供了包含至少两种不同的核酸载体的组合物，其中：所述至少两种不同的腺相关病毒(AAV)载体中的每一种均包含编码序列，所述编码序列编码毛细胞靶蛋白的不同部分，所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分中的每一个的氨基酸序列可以任选地与所述编码的部分中的不同的一个部分的氨基酸序列部分地重叠；所述至少两种不同的载体中单一载体均不编码全长毛细胞靶蛋白；所述编码序列中的至少一个包含跨越毛细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述两个相邻外显子之间缺少内含子序列；以及所述至少两种不同的载体，当被引入到灵长类动物细胞中时，经历彼此串联或同源重组，从而形成编码全长毛细胞靶蛋白的重组核酸。

本文提供了包含至少两种不同的核酸载体的组合物，其中：所述至少两种不同的腺相关病毒(AAV)载体中的每一种均包含编码毛细胞靶蛋白的不同部分的编码序列，所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分中的每一个的氨基酸序列可以任选地与所述编码的部分中的不同的一个部分的氨基酸序列部分地重叠；所述至少两种不同的载体中单一载体均不编码全长蛋白质；所述编码序列中的至少一个包含跨越毛细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述两个相邻外显子之间缺乏内含子序列；并且当被引入到灵长类动物细胞时，所述至少两种不同的载体经历彼此串联或同源重组，从而形成编码全长毛细胞靶蛋白的重组核酸。

在本文所述的任何组合物的一些实施方案中，所述编码的部分之一的氨基酸序列与所述编码的部分中的不同的一个部分的氨基酸序列重叠。在本文所述的任何组合物的一些实施方案中，所述编码的部分中的每一个的氨基酸序列与不同的编码的部分的氨基酸序列部分地重叠。在本文所述的任何组合物的一些实施方案中，重叠氨基酸序列的长度为30个氨基酸残基至约390个氨基酸残基。

在本文所述的任何组合物的一些实施方案中，所述至少两种不同的载体中的每一种包含内含子的不同区段，其中所述内含子包含存在于毛细胞靶基因组DNA中的内含子的核苷酸序列，并且其中两个不同的区段在序列上重叠至少100个核苷酸。在本文所述的任何组合物的一些实施方案中，所述两个不同的区段在序列上重叠约30个核苷酸至约390个核苷酸。在本文所述的任何组合物的一些实施方案中，所述至少两种不同的载体中的每一种的核苷酸序列的长度为约30个核苷酸至约390个核苷酸。在本文所述的任何组合物的一些实施方案中，所述至少两种不同的载体中的每一种的核苷酸序列的长度为30个核苷酸至340个核苷酸。

在本文所述的任何组合物的一些实施方案中，所述组合物中不同载体的数目为2。在本文所述的任何组合物的一些实施方案中，所述两种不同的载体中的第一载体包含编码毛细胞靶蛋白的N末端部分的编码序列。在本文所述的任何组合物的一些实施方案中，毛细胞靶蛋白的N末端部分的长度为约30个氨基酸至约390个氨基酸。在本文所述的任何组合物的一些实施方案中，毛细胞靶蛋白的N末端部分的长度为约30个氨基酸至约340个氨基酸。在本文所述的任何组合物的一些实施方案中，第一载体还包含启动子和Kozak序列之一者或两者。在本文所述的任何组合物的一些实施方案中，第一载体包含启动子，所述启动子为诱导型启动子、组成型启动子或组织特异性启动子。

在本文所述的任何组合物的一些实施方案中，所述两种不同的载体中的第二载体包括编码毛细胞靶蛋白的C末端部分的编码序列。在本文所述的任何组合物的一些实施方案中，所述毛细胞靶蛋白的C-末端部分的长度为约30个氨基酸至约390个氨基酸。在本文所述的任何组合物的一些实施方案中，毛细胞靶蛋白的C-末端部分的长度为约30个氨基酸至约340个氨基酸。在本文所述的任何组合物的一些实施方案中，第二载体还包含poly(dA)序列。

本文还提供了包含两种不同的核酸载体的组合物，其中：所述两种不同的核酸载体中的第一核酸载体包含启动子、位于所述启动子3’的编码毛细胞靶蛋白的N末端部分的第一编码序列和位于所述第一编码序列的3’末端的剪接供体信号序列；以及所述两种不同的核酸载体中的第二核酸载体包含剪接受体信号序列、位于所述剪接受体信号序列的3'末端的编码毛细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多聚腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的氨基酸序列不重叠，其中所述两种不同的载体中单一载体均不编码所述全长毛细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长毛细胞靶蛋白的重组RNA分子。

在本文所述的任何组合物的一些实施方案中，所述编码序列中的至少一个包含跨越毛细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在相邻外显子之间缺乏内含子序列。

本文还提供了组合物，其包含：第一核酸载体，其包含启动子、位于所述启动子的3'的编码毛细胞靶蛋白的N末端部分的第一编码序列、位于所述第一编码序列的3’末端的剪接供体信号序列，和位于所述剪接供体信号序列的3’的第一可检测标记基因；和第二核酸载体，其与所述第一核酸载体不同，包含第二可检测标记基因、位于所述第二可检测标记基因的3’的剪接受体信号序列、位于所述剪接受体信号序列的3’末端的编码毛细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的各自的氨基酸序列彼此不重叠，其中所述两种不同的载体中单一载体均不编码所述全长毛细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长毛细胞靶蛋白的重组RNA分子。

在本文所述的任何组合物的一些实施方案中，所述编码序列中的至少一个包含跨越毛细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在相邻外显子之间缺乏内含子序列。在本文所述的任何组合物的一些实施方案中，所述第一可检测标记基因或所述第二可检测标记基因是碱性磷酸酶。在本文所述的任何组合物的一些实施方案中，所述第一可检测标记基因和所述第二可检测标记基因是相同的。

本文还提供了组合物，其包含：第一核酸载体，其包含启动子、位于所述启动子的3’的编码毛细胞靶蛋白的N末端部分的第一编码序列、位于所述第一编码序列的3’末端的剪接供体信号序列和位于所述剪接供体信号序列的3’的F1噬菌体重组发生区；和第二核酸载体，其与所述第一核酸载体不同，包含第二F1噬菌体重组发生区、位于所述第二F1噬菌体重组发生区的3’的剪接受体信号序列、位于所述剪接受体信号序列的3’末端的编码毛细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的各自的氨基酸序列彼此不重叠，其中所述两种不同的载体中单一载体均不编码所述全长毛细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的剪接供体信号与另一个转录物上的剪接受体信号之间发生剪接，从而形成编码全长毛细胞靶蛋白的重组RNA分子。

在本文所述的任何组合物的一些实施方案中，所述编码序列中的至少一个包含跨越毛细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在两个相邻外显子之间缺乏内含子序列。

本文还提供了包含单一腺相关病毒(AAV)载体的组合物，其中所述单一AAV载体包含编码毛细胞靶蛋白的核酸序列；当被引入到灵长类动物细胞时，在所述毛细胞靶基因的基因座处产生编码全长毛细胞靶蛋白的核酸，并且所述灵长类动物表达所述毛细胞靶蛋白。

在本文所述的任何组合物的一些实施方案中，所述组合物还包含药学上可接受的赋形剂。

本文还提供了包括本文所述的任何组合物的试剂盒。在本文所述的任何试剂盒的一些实施方案中，试剂盒还包括包含所述组合物的预装式注射器。

本文还提供了校正灵长类动物内耳的毛细胞中的毛细胞靶基因缺陷的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物，其中所述施用修复所述灵长类动物内耳的毛细胞中的毛细胞靶基因缺陷。

本文还提供了升高灵长类动物内耳的毛细胞中的毛细胞靶蛋白的表达水平的方法，所述方法包括向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物，其中所述施用使得所述灵长类动物内耳的所述毛细胞中的所述毛细胞靶蛋白的表达水平升高。

在本文所述的任何方法的一些实施方案中，所述灵长类动物先前已被确定具有缺陷型毛细胞靶基因。

本文还提供了治疗被鉴定为具有缺陷型毛细胞靶基因的灵长类动物的非综合征性感音神经性听力损失的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物。

在本文所述的任何方法的一些实施方案中，所述方法还包括在所述施用步骤之前，确定所述灵长类动物具有缺陷型毛细胞靶基因。

本文还提供了恢复被鉴定或诊断为患有听力损失的灵长类动物的听力的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的如本文所述的任何组合物。

在本文所述的任何方法的一些实施方案中，所述方法还包括在施用步骤之前，确定灵长类动物具有缺陷型毛细胞靶基因。

本文还提供了恢复被鉴定或诊断为患有内耳病症的灵长类动物的突触并且/或者保留其螺旋神经节神经的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物。

在本文所述的任何方法的一些实施方案中，所述方法还包括在施用步骤之前，确定灵长类动物具有缺陷型毛细胞靶基因。

本文还提供了包括向灵长类动物的内耳施用治疗有效量的本文所述的任何组合物的方法。

在本文所述的任何方法的一些实施方案中，所述灵长类动物先前已被鉴定为具有缺陷型毛细胞靶基因。

术语“一个/种(a)”和“一个/种(an)”是指一个/种或不止一个/种(即，至少一个/种)该冠词的语法对象。举例来说，“一个(an)元件”涵盖一个元件和不止一个元件。

术语“支持细胞靶蛋白”意指在灵长类动物的支持细胞中表达并且在功能上至少部分有助于灵长类动物的听力的蛋白质。支持细胞靶蛋白的非限制性实例包括GJB2和SLC26A4。

术语“支持细胞靶基因中的突变”是指野生型支持细胞靶基因中的修饰，所述修饰导致产生与野生型支持细胞靶蛋白相比具有：一个或多个氨基酸的缺失、一个或多个氨基酸取代和一个或多个氨基酸插入中的一者或多者的支持细胞靶蛋白，并且/或者导致与不具有突变的灵长类动物细胞中的所述编码的支持细胞靶蛋白的表达水平相比，灵长类动物细胞中的编码的支持细胞靶蛋白的表达水平降低。在一些实施方案中，突变可导致在一个或多个氨基酸(例如，2个、3个、4个、5个、6个、7个、8个、9个、10个、11个、12个、13个、14个、1516个、17个、18个、19个或20个氨基酸)处具有缺失的支持细胞靶蛋白产生。在一些实施方案中，所述突变可在支持细胞靶基因中导致移码。

术语“毛细胞靶蛋白”意指在灵长类动物的毛细胞中表达，并且在功能上至少部分有助于灵长类动物的听力的蛋白质。毛细胞靶蛋白的非限制性实例包括覆膜蛋白α(tectorin alpha)(TECTA)、非常规肌球蛋白-15(MYO15A)、肌球蛋白IIIA(MYO3A)、肌球蛋白VI(MYO6)、肌球蛋白VIIA(MYO7A)、钙粘蛋白相关23(CDH23)、胶原XIα2型链(COL11A2)、脂氧合酶同源结构域1(LOXHD1)、原钙粘蛋白相关15(PCDH15)、旋蛋白(whirlin)(WHRN)、耳畸蛋白(OTOF)基因、trio rho鸟嘌呤核苷酸交换因子(TRIO)和f-肌动蛋白结合蛋白(TRIOBP)基因、硬纤毛蛋白(stereocilin)(STRC)基因、pejvakin(PJVK)基因、norrin半胱氨酸结生长因子(NDP)基因、clarin 1(CLRN1)基因、跨膜通道样1(TMC1)基因、血管内皮生长因子(VEGF)基因和热休克蛋白家族A(Hsp70)成员1A(HSPA1A)基因。

术语“毛细胞靶基因中的突变”是指野生型毛细胞靶基因中的修饰，所述修饰导致产生与野生型毛细胞靶蛋白相比具有：一个或多个氨基酸的缺失、一个或多个氨基酸取代和一个或多个氨基酸插入中的一者或多者的毛细胞靶蛋白，并且/或者导致与不具有突变的灵长类动物细胞中的编码的毛细胞靶蛋白的表达水平相比，灵长类动物细胞中的所述编码的毛细胞靶蛋白的表达水平降低。在一些实施方案中，突变可导致在一个或多个氨基酸(例如，2个、3个、4个、5个、6个、7个、8个、9个、10个、11个、12个、13个、14个、15 16个、17个、18个、19个或20个氨基酸)处具有缺失的毛细胞靶蛋白产生。在一些实施方案中，所述突变可在毛细胞靶基因中导致移码。

已知术语“移码”在本领域中涵盖编码序列中导致编码序列的阅读框中的移位的任何突变。在一些实施方案中，移码可导致无功能的蛋白质。在一些实施方案中，点突变可以是无义突变(即，在基因的外显子中导致提前终止密码子)。无义突变可导致产生可以具有或可以不具有功能的截短的蛋白质(与相应的野生型蛋白质相比)。在一些实施方案中，所述突变可导致毛细胞靶mRNA或毛细胞靶蛋白或mRNA和蛋白两者的表达损失(或水平降低)。在一些实施方案中，与野生型毛细胞靶蛋白相比，所述突变可导致改变的毛细胞靶蛋白的产生，所述改变的毛细胞靶蛋白的一种或多种生物活性(功能)损失或降低。在一些实施方案中，所述突变可导致支持细胞靶mRNA或支持细胞靶蛋白或mRNA和蛋白两者的表达损失(或水平降低)。在一些实施方案中，与野生型支持细胞靶蛋白相比，所述突变可导致改变的支持细胞靶蛋白产生，所述改变的支持细胞靶蛋白的一种或多种生物活性(功能)损失或降低。

在一些实施方案中，所述突变是一个或多个核苷酸至毛细胞靶基因中的插入。在一些实施方案中，所述突变存在于毛细胞靶基因的调控序列(即，该基因的非编码序列的一部分)中。在一些实施方案中，调控序列中的突变可存在于启动子或增强子区域中，并阻止或减少毛细胞靶基因的适当转录。在一些实施方案中，所述突变是一个或多个核苷酸至支持细胞靶基因中的插入。在一些实施方案中，所述突变位于支持细胞靶基因的调控序列(即，该基因的非编码序列的一部分)。在一些实施方案中，调控序列中的突变可存在于启动子或增强子区域中，并阻止或减少支持细胞靶基因的适当转录。术语“保守突变”是指不改变在突变位点处编码的氨基酸的突变(由于密码子简并性)。

可通过本领域已知的标准技术诸如定点诱变和PCR介导的诱变将修饰引入核苷酸序列中。保守氨基酸取代是其中氨基酸残基被具有相似侧链的氨基酸残基替代的氨基酸取代。本领域已经定义了具有相似侧链的氨基酸残基的家族。这些家族包括具有碱性侧链(例如，赖氨酸、精氨酸和组氨酸)、酸性侧链(例如。天冬氨酸和谷氨酸)、不带电荷的极性侧链(例如，甘氨酸、天冬酰胺、谷氨酰胺、丝氨酸、苏氨酸、酪氨酸、半胱氨酸和色氨酸)、非极性侧链(例如，丙氨酸、缬氨酸、亮氨酸、异亮氨酸、脯氨酸、苯丙氨酸和蛋氨酸)、β-支链侧链(例如，苏氨酸、缬氨酸和异亮氨酸)和芳族侧链(例如，酪氨酸、苯丙氨酸、色氨酸和组氨酸)的氨基酸。

除非另外规定，否则“编码氨基酸序列的核苷酸序列”包括是彼此的简并形式并因此编码相同的氨基酸序列的所有核苷酸序列。

术语“内源的”是指源自生物体、细胞或组织内的任何材料。

术语“外源的”是指从生物体、细胞或组织的外部引入或源自外部的任何材料，所述材料不从将引入其的同一生物体、细胞或组织产生，或者不源自所述同一生物体、细胞或组织。

术语“分离的”意指从天然状态改变或去除。例如，天然存在于活的动物中的核酸或肽不是“分离的”，但与共存材料部分或完全分开的相同核酸或肽是“分离的”。分离的核酸或蛋白质可以以基本上纯化的形式存在，或者可以存在于非天然环境例如宿主细胞中。

术语“转染的”、“转化的”或“转导的”是指将外源性核酸转移或引入细胞的过程。“转染的”、“转化的”或“转导的”灵长类动物细胞是已用外源性核酸转染、转化或转导的细胞。

术语“表达”是指编码蛋白质的特定核苷酸序列的转录和/或翻译。

术语“瞬时表达”是指非整合编码序列在短时间段(例如，数小时或数天)中的表达。在细胞(例如，灵长类动物细胞)中瞬时表达的编码序列在多轮细胞分裂后丢失。

术语“灵长类动物”意图包括任何灵长类动物(例如，人类、非人灵长类动物(例如，猿猴(例如，猴子(例如狨猴、狒狒或猕猴)或猿(例如，大猩猩、长臂猿、猩猩或黑猩猩)。在一些实施方案中，灵长类动物患有听力损失或有患听力损失的风险。在一些实施方案中，灵长类动物先前已经被鉴定为在毛细胞靶基因(例如，OTOF基因、TRIOBP基因、STRC基因、PJVK基因、NDP基因、CLRN1基因、TMC1基因、VEGF基因或HSPA1A基因)中具有突变。在一些实施方案中，灵长类动物先前已经被鉴定为在支持细胞靶基因(例如，GJB2基因或SLC26A4基因)中具有突变。在一些实施方案中，灵长类动物先前已被鉴定为在GJB2基因中具有突变。在一些实施方案中，灵长类动物先前已被鉴定为在SLC26A4基因中具有突变。在一些实施方案中，灵长类动物已被鉴定为在毛细胞靶基因(例如，OTOF基因、TRIOBP基因、STRC基因、PJVK基因、NDP基因、CLRN1基因、TMC1基因、VEGF基因或HSPA1A基因)中具有突变，并已被诊断为患有听力损失。在一些实施方案中，灵长类动物已经被鉴定为在支持细胞靶基因(例如，GBJ2基因或SLC26A4基因)中具有突变，并且已经被诊断患有听力损失。在一些实施方案中，灵长类动物已被鉴定为患有听力损失。

当治疗导致灵长类动物的疾病状态(听力损失，例如，非综合征性感音神经性听力损失或综合征性感音神经性听力损失)的一种或多种症状的数量、严重程度和频率中的一种或多种降低时，所述治疗是“治疗有效的”。在一些实施方案中，治疗有效量的组合物可导致活性靶蛋白(例如，支持细胞靶蛋白(例如，具有所需活性的野生型全长支持细胞靶蛋白或支持细胞靶蛋白的变体))(例如，与用该组合物处理之前的表达水平相比)或毛细胞靶蛋白(例如，具有所需活性的野生型全长毛细胞靶蛋白或毛细胞靶蛋白的变体))(例如，与用该组合物处理之前的表达水平相比)的表达水平升高。在一些实施方案中，治疗有效量的组合物可导致靶细胞(例如，支持细胞或毛细胞)中活性靶蛋白(例如，活性支持细胞靶蛋白(例如，野生型全长支持细胞靶蛋白或活性变体)或活性毛细胞靶蛋白(例如，野生型全长毛细胞靶蛋白或活性变体))的表达水平升高。在一些实施方案中，治疗有效量的组合物可导致靶细胞中活性靶蛋白(例如，活性支持细胞靶蛋白(例如，野生型全长支持细胞靶蛋白或活性变体)或活性毛细胞靶蛋白(例如，野生型全长毛细胞靶蛋白或活性变体)的表达水平升高和/或靶蛋白(例如，支持细胞靶蛋白或毛细胞靶蛋白)的一种或多种活性增强(例如，与参考水平，诸如治疗前的灵长类动物中的一个或多个水平、在靶基因(例如，支持细胞靶基因或毛细胞靶基因)中具有突变的灵长类动物中的一个或多个水平或患有听力损失(例如，非综合征性感音神经性听力损失或综合征性感音神经性听力损失)的灵长类动物或灵长类动物群中的一个或多个水平相比)。

术语“核酸”或“多核苷酸”是指单链或双链形式的脱氧核糖核酸(DNA)或核糖核酸(RNA)或其组合。除非特别限制，否则所述术语涵盖含有已知的天然核苷酸类似物的核酸，所述天然核苷酸类似物具有与参考核苷酸相似的结合特性。除非另有说明，否则特定的核酸序列也隐含地涵盖互补序列以及明确指示的序列。在本文所述的任何核酸的一些实施方案中，核酸为DNA。在本文所述的任何核酸的一些实施方案中，核酸为RNA。

术语“活性毛细胞靶蛋白”意指由这样的DNA编码的蛋白质，所述DNA，如果取代原本属于野生型灵长类动物的毛细胞中两个编码全长毛细胞靶蛋白的野生型等位基因，并且如果在该灵长类动物的毛细胞中表达，会导致该灵长类动物的听力水平接近为完全野生型的类似灵长类动物的正常听力水平。活性毛细胞靶蛋白的非限制性实例是全长毛细胞靶蛋白(例如，本文所述的任何全长毛细胞靶蛋白)。

术语“活性支持细胞靶蛋白”是指由这样的DNA编码的蛋白质，所述DNA，如果取代原本属于野生型灵长类动物的支持细胞中两个编码全长支持细胞靶蛋白的野生型等位基因，并且如果在该灵长类动物的支持细胞中表达，会导致该灵长类动物的听力水平接近为完全野生型的类似灵长类动物的正常听力水平。活性支持细胞靶蛋白的非限制性实例是全长支持细胞靶蛋白(例如，本文所述的任何全长支持细胞靶蛋白)。

例如，活性靶蛋白(例如，活性支持细胞靶蛋白或活性毛细胞靶蛋白)可包含野生型全长靶蛋白(例如，支持细胞靶蛋白(例如，野生型人全长支持细胞靶蛋白)或毛细胞靶蛋白(例如，野生型人全长毛细胞靶蛋白))的序列，所述野生型全长靶蛋白的序列包含1个氨基酸取代至约160个氨基酸取代、1个氨基酸取代至约155个氨基酸取代、1个氨基酸取代至约150个氨基酸取代、1个氨基酸取代至约145个氨基酸取代、1个氨基酸取代至约140个氨基酸取代、1个氨基酸取代至约135个氨基酸取代、1个氨基酸取代至约130个氨基酸取代、1个氨基酸取代至约125个氨基酸取代、1个氨基酸取代至约120个氨基酸取代、1个氨基酸取代至约115个氨基酸取代、1个氨基酸取代至约110个氨基酸取代、1个氨基酸取代至约105个氨基酸取代、1个氨基酸取代至约100个氨基酸取代、1个氨基酸取代至约95个氨基酸取代、1个氨基酸取代至约90个氨基酸取代、1个氨基酸取代至约85个氨基酸取代、1个氨基酸取代至约80个氨基酸取代、1个氨基酸取代至约75个氨基酸取代、1个氨基酸取代至约70个氨基酸取代、1个氨基酸取代至约65个氨基酸取代、1个氨基酸取代至约60个氨基酸取代、1个氨基酸取代至约55个氨基酸取代、1个氨基酸取代至约50个氨基酸取代、1个氨基酸取代至约45个氨基酸取代、1个氨基酸取代至约40个氨基酸取代、1个氨基酸取代至约35个氨基酸取代、1个氨基酸取代至约30个氨基酸取代、1个氨基酸取代至约25个氨基酸取代、1个氨基酸取代至约20个氨基酸取代、1个氨基酸取代至约15个氨基酸取代、1个氨基酸取代至约10个氨基酸取代、1个氨基酸取代至约9个氨基酸取代、1个氨基酸取代至约8个氨基酸取代、1个氨基酸取代至约7个氨基酸取代、1个氨基酸取代至约6个氨基酸取代、1个氨基酸取代至约5个氨基酸取代、1个氨基酸取代至约4个氨基酸取代、1个氨基酸取代至约3个氨基酸取代、约2个氨基酸取代至约160个氨基酸取代、约2个氨基酸取代至约155个氨基酸取代、约2个氨基酸取代至约150个氨基酸取代、约2个氨基酸取代至约145个氨基酸取代、约2个氨基酸取代至约140个氨基酸取代、约2个氨基酸取代至约135个氨基酸取代、约2个氨基酸取代至约130个氨基酸取代、约2个氨基酸取代至约125个氨基酸取代、约2个氨基酸取代至约120个氨基酸取代、约2个氨基酸取代至约115个氨基酸取代、约2个氨基酸取代至约110个氨基酸取代、约2个氨基酸取代至约105个氨基酸取代、约2个氨基酸取代至约100个氨基酸取代、约2个氨基酸取代至约95个氨基酸取代、约2个氨基酸取代至约90个氨基酸取代、约2个氨基酸取代至约85个氨基酸取代、约2个氨基酸取代至约80个氨基酸取代、约2个氨基酸取代至约75个氨基酸取代、约2个氨基酸取代至约70个氨基酸取代、约2个氨基酸取代至约65个氨基酸取代、约2个氨基酸取代至约60个氨基酸取代、约2个氨基酸取代至约55个氨基酸取代、约2个氨基酸取代至约50个氨基酸取代、约2个氨基酸取代至约45个氨基酸取代、约2个氨基酸取代至约40个氨基酸取代、约2个氨基酸取代至约35个氨基酸取代、约2个氨基酸取代至约30个氨基酸取代、约2个氨基酸取代至约25个氨基酸取代、约2个氨基酸取代至约20个氨基酸取代、约2个氨基酸取代至约15个氨基酸取代、约2个氨基酸取代至约10个氨基酸取代、约2个氨基酸取代至约9个氨基酸取代、约2个氨基酸取代至约8个氨基酸取代、约2个氨基酸取代至约7个氨基酸取代、约2个氨基酸取代至约6个氨基酸取代、约2个氨基酸取代至约5个氨基酸取代、约2个氨基酸取代至约4个氨基酸取代、约3个氨基酸取代至约160个氨基酸取代、约3个氨基酸取代至约155个氨基酸取代、约3个氨基酸取代至约150个氨基酸取代、约3个氨基酸取代至约145个氨基酸取代、约3个氨基酸取代至约140个氨基酸取代、约3个氨基酸取代至约135个氨基酸取代、约3个氨基酸取代至约130个氨基酸取代、约3个氨基酸取代至约125个氨基酸取代、约3个氨基酸取代至约120个氨基酸取代、约3个氨基酸取代至约115个氨基酸取代、约3个氨基酸取代至约110个氨基酸取代、约3个氨基酸取代至约105个氨基酸取代、约3个氨基酸取代至约100个氨基酸取代、约3个氨基酸取代至约95个氨基酸取代、约3个氨基酸取代至约90个氨基酸取代、约3个氨基酸取代至约85个氨基酸取代、约3个氨基酸取代至约80个氨基酸取代、约3个氨基酸取代至约75个氨基酸取代、约3个氨基酸取代至约70个氨基酸取代、约3个氨基酸取代至约65个氨基酸取代、约3个氨基酸取代至约60个氨基酸取代、约3个氨基酸取代至约55个氨基酸取代、约3个氨基酸取代至约50个氨基酸取代、约3个氨基酸取代至约45个氨基酸取代、约3个氨基酸取代至约40个氨基酸取代、约3个氨基酸取代至约35个氨基酸取代、约3个氨基酸取代至约30个氨基酸取代、约3个氨基酸取代至约25个氨基酸取代、约3个氨基酸取代至约20个氨基酸取代、约3个氨基酸取代至约15个氨基酸取代、约3个氨基酸取代至约10个氨基酸取代、约3个氨基酸取代至约9个氨基酸取代、约3个氨基酸取代至约8个氨基酸取代、约3个氨基酸取代至约7个氨基酸取代、约3个氨基酸取代至约6个氨基酸取代、约3个氨基酸取代至约5个氨基酸取代、约4个氨基酸取代至约160个氨基酸取代、约4个氨基酸取代至约155个氨基酸取代、约4个氨基酸取代至约150个氨基酸取代、约4个氨基酸取代至约145个氨基酸取代、约4个氨基酸取代至约140个氨基酸取代、约4个氨基酸取代至约135个氨基酸取代、约4个氨基酸取代至约130个氨基酸取代、约4个氨基酸取代至约125个氨基酸取代、约4个氨基酸取代至约120个氨基酸取代、约4个氨基酸取代至约115个氨基酸取代、约4个氨基酸取代至约110个氨基酸取代、约4个氨基酸取代至约105个氨基酸取代、约4个氨基酸取代至约100个氨基酸取代、约4个氨基酸取代至约95个氨基酸取代、约4个氨基酸取代至约90个氨基酸取代、约4个氨基酸取代至约85个氨基酸取代、约4个氨基酸取代至约80个氨基酸取代、约4个氨基酸取代至约75个氨基酸取代、约4个氨基酸取代至约70个氨基酸取代、约4个氨基酸取代至约65个氨基酸取代、约4个氨基酸取代至约60个氨基酸取代、约4个氨基酸取代至约55个氨基酸取代、约4个氨基酸取代至约50个氨基酸取代、约4个氨基酸取代至约45个氨基酸取代、约4个氨基酸取代至约40个氨基酸取代、约4个氨基酸取代至约35个氨基酸取代、约4个氨基酸取代至约30个氨基酸取代、约4个氨基酸取代至约25个氨基酸取代、约4个氨基酸取代至约20个氨基酸取代、约4个氨基酸取代至约15个氨基酸取代、约4个氨基酸取代至约10个氨基酸取代、约4个氨基酸取代至约9个氨基酸取代、约4个氨基酸取代至约8个氨基酸取代、约4个氨基酸取代至约7个氨基酸取代、约4个氨基酸取代至约6个氨基酸取代、约5个氨基酸取代至约160个氨基酸取代、约5个氨基酸取代至约155个氨基酸取代、约5个氨基酸取代至约150个氨基酸取代、约5个氨基酸取代至约145个氨基酸取代、约5个氨基酸取代至约140个氨基酸取代、约5个氨基酸取代至约135个氨基酸取代、约5个氨基酸取代至约130个氨基酸取代、约5个氨基酸取代至约125个氨基酸取代、约5个氨基酸取代至约120个氨基酸取代、约5个氨基酸取代至约115个氨基酸取代、约5个氨基酸取代至约110个氨基酸取代、约5个氨基酸取代至约105个氨基酸取代、约5个氨基酸取代至约100个氨基酸取代、约5个氨基酸取代至约95个氨基酸取代、约5个氨基酸取代至约90个氨基酸取代、约5个氨基酸取代至约85个氨基酸取代、约5个氨基酸取代至约80个氨基酸取代、约5个氨基酸取代至约75个氨基酸取代、约5个氨基酸取代至约70个氨基酸取代、约5个氨基酸取代至约65个氨基酸取代、约5个氨基酸取代至约60个氨基酸取代、约5个氨基酸取代至约55个氨基酸取代、约5个氨基酸取代至约50个氨基酸取代、约5个氨基酸取代至约45个氨基酸取代、约5个氨基酸取代至约40个氨基酸取代、约5个氨基酸取代至约35个氨基酸取代、约5个氨基酸取代至约30个氨基酸取代、约5个氨基酸取代至约25个氨基酸取代、约5个氨基酸取代至约20个氨基酸取代、约5个氨基酸取代至约15个氨基酸取代、约5个氨基酸取代至约10个氨基酸取代、约5个氨基酸取代至约9个氨基酸取代、约5个氨基酸取代至约8个氨基酸取代、约5个氨基酸取代至约7个氨基酸取代、约6个氨基酸取代至约160个氨基酸取代、约6个氨基酸取代至约155个氨基酸取代、约6个氨基酸取代至约150个氨基酸取代、约6个氨基酸取代至约145个氨基酸取代、约6个氨基酸取代至约140个氨基酸取代、约6个氨基酸取代至约135个氨基酸取代、约6个氨基酸取代至约130个氨基酸取代、约6个氨基酸取代至约125个氨基酸取代、约6个氨基酸取代至约120个氨基酸取代、约6个氨基酸取代至约115个氨基酸取代、约6个氨基酸取代至约110个氨基酸取代、约6个氨基酸取代至约105个氨基酸取代、约6个氨基酸取代至约100个氨基酸取代、约6个氨基酸取代至约95个氨基酸取代、约6个氨基酸取代至约90个氨基酸取代、约6个氨基酸取代至约85个氨基酸取代、约6个氨基酸取代至约80个氨基酸取代、约6个氨基酸取代至约75个氨基酸取代、约6个氨基酸取代至约70个氨基酸取代、约6个氨基酸取代至约65个氨基酸取代、约6个氨基酸取代至约60个氨基酸取代、约6个氨基酸取代至约55个氨基酸取代、约6个氨基酸取代至约50个氨基酸取代、约6个氨基酸取代至约45个氨基酸取代、约6个氨基酸取代至约40个氨基酸取代、约6个氨基酸取代至约35个氨基酸取代、约6个氨基酸取代至约30个氨基酸取代、约6个氨基酸取代至约25个氨基酸取代、约6个氨基酸取代至约20个氨基酸取代、约6个氨基酸取代至约15个氨基酸取代、约6个氨基酸取代至约10个氨基酸取代、约6个氨基酸取代至约9个氨基酸取代、约6个氨基酸取代至约8个氨基酸取代、约7个氨基酸取代至约160个氨基酸取代、约7个氨基酸取代至约155个氨基酸取代、约7个氨基酸取代至约150个氨基酸取代、约7个氨基酸取代至约145个氨基酸取代、约7个氨基酸取代至约140个氨基酸取代、约7个氨基酸取代至约135个氨基酸取代、约7个氨基酸取代至约130个氨基酸取代、约7个氨基酸取代至约125个氨基酸取代、约7个氨基酸取代至约120个氨基酸取代、约7个氨基酸取代至约115个氨基酸取代、约7个氨基酸取代至约110个氨基酸取代、约7个氨基酸取代至约105个氨基酸取代、约7个氨基酸取代至约100个氨基酸取代、约7个氨基酸取代至约95个氨基酸取代、约7个氨基酸取代至约90个氨基酸取代、约7个氨基酸取代至约85个氨基酸取代、约7个氨基酸取代至约80个氨基酸取代、约7个氨基酸取代至约75个氨基酸取代、约7个氨基酸取代至约70个氨基酸取代、约7个氨基酸取代至约65个氨基酸取代、约7个氨基酸取代至约60个氨基酸取代、约7个氨基酸取代至约55个氨基酸取代、约7个氨基酸取代至约50个氨基酸取代、约7个氨基酸取代至约45个氨基酸取代、约7个氨基酸取代至约40个氨基酸取代、约7个氨基酸取代至约35个氨基酸取代、约7个氨基酸取代至约30个氨基酸取代、约7个氨基酸取代至约25个氨基酸取代、约7个氨基酸取代至约20个氨基酸取代、约7个氨基酸取代至约15个氨基酸取代、约7个氨基酸取代至约10个氨基酸取代、约7个氨基酸取代至约9个氨基酸取代、约8个氨基酸取代至约160个氨基酸取代、约8个氨基酸取代至约155个氨基酸取代、约8个氨基酸取代至约150个氨基酸取代、约8个氨基酸取代至约145个氨基酸取代、约8个氨基酸取代至约140个氨基酸取代、约8个氨基酸取代至约135个氨基酸取代、约8个氨基酸取代至约130个氨基酸取代、约8个氨基酸取代至约125个氨基酸取代、约8个氨基酸取代至约120个氨基酸取代、约8个氨基酸取代至约115个氨基酸取代、约8个氨基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取代至约100个氨基酸取代、约50个氨基酸取代至约95个氨基酸取代、约50个氨基酸取代至约90个氨基酸取代、约50个氨基酸取代至约85个氨基酸取代、约50个氨基酸取代至约80个氨基酸取代、约50个氨基酸取代至约75个氨基酸取代、约50个氨基酸取代至约70个氨基酸取代、约50个氨基酸取代至约65个氨基酸取代、约50个氨基酸取代至约60个氨基酸取代、约50个氨基酸取代至约55个氨基酸取代、约60个氨基酸取代至约160个氨基酸取代、约60个氨基酸取代至约155个氨基酸取代、约60个氨基酸取代至约150个氨基酸取代、约60个氨基酸取代至约145个氨基酸取代、约60个氨基酸取代至约140个氨基酸取代、约60个氨基酸取代至约135个氨基酸取代、约60个氨基酸取代至约130个氨基酸取代、约60个氨基酸取代至约125个氨基酸取代、约60个氨基酸取代至约120个氨基酸取代、约60个氨基酸取代至约115个氨基酸取代、约60个氨基酸取代至约110个氨基酸取代、约60个氨基酸取代至约105个氨基酸取代、约60个氨基酸取代至约100个氨基酸取代、约60个氨基酸取代至约95个氨基酸取代、约60个氨基酸取代至约90个氨基酸取代、约60个氨基酸取代至约85个氨基酸取代、约60个氨基酸取代至约80个氨基酸取代、约60个氨基酸取代至约75个氨基酸取代、约60个氨基酸取代至约70个氨基酸取代、约60个氨基酸取代至约65个氨基酸取代、约70个氨基酸取代至约160个氨基酸取代、约70个氨基酸取代至约155个氨基酸取代、约70个氨基酸取代至约150个氨基酸取代、约70个氨基酸取代至约145个氨基酸取代、约70个氨基酸取代至约140个氨基酸取代、约70个氨基酸取代至约135个氨基酸取代、约70个氨基酸取代至约130个氨基酸取代、约70个氨基酸取代至约125个氨基酸取代、约70个氨基酸取代至约120个氨基酸取代、约70个氨基酸取代至约115个氨基酸取代、约70个氨基酸取代至约110个氨基酸取代、约70个氨基酸取代至约105个氨基酸取代、约70个氨基酸取代至约100个氨基酸取代、约70个氨基酸取代至约95个氨基酸取代、约70个氨基酸取代至约90个氨基酸取代、约70个氨基酸取代至约85个氨基酸取代、约70个氨基酸取代至约80个氨基酸取代、约70个氨基酸取代至约75个氨基酸取代、约80个氨基酸取代至约160个氨基酸取代、约80个氨基酸取代至约155个氨基酸取代、约80个氨基酸取代至约150个氨基酸取代、约80个氨基酸取代至约145个氨基酸取代、约80个氨基酸取代至约140个氨基酸取代、约80个氨基酸取代至约135个氨基酸取代、约80个氨基酸取代至约130个氨基酸取代、约80个氨基酸取代至约125个氨基酸取代、约80个氨基酸取代至约120个氨基酸取代、约80个氨基酸取代至约115个氨基酸取代、约80个氨基酸取代至约110个氨基酸取代、约80个氨基酸取代至约105个氨基酸取代、约80个氨基酸取代至约100个氨基酸取代、约80个氨基酸取代至约95个氨基酸取代、约80个氨基酸取代至约90个氨基酸取代、约80个氨基酸取代至约85个氨基酸取代、约90个氨基酸取代至约160个氨基酸取代、约90个氨基酸取代至约155个氨基酸取代、约90个氨基酸取代至约150个氨基酸取代、约90个氨基酸取代至约145个氨基酸取代、约90个氨基酸取代至约140个氨基酸取代、约90个氨基酸取代至约135个氨基酸取代、约90个氨基酸取代至约130个氨基酸取代、约90个氨基酸取代至约125个氨基酸取代、约90个氨基酸取代至约120个氨基酸取代、约90个氨基酸取代至约115个氨基酸取代、约90个氨基酸取代至约110个氨基酸取代、约90个氨基酸取代至约105个氨基酸取代、约90个氨基酸取代至约100个氨基酸取代、约90个氨基酸取代至约95个氨基酸取代、约100个氨基酸取代至约160个氨基酸取代、约100个氨基酸取代至约155个氨基酸取代、约100个氨基酸取代至约150个氨基酸取代、约100个氨基酸取代至约145个氨基酸取代、约100个氨基酸取代至约140个氨基酸取代、约100个氨基酸取代至约135个氨基酸取代、约100个氨基酸取代至约130个氨基酸取代、约100个氨基酸取代至约125个氨基酸取代、约100个氨基酸取代至约120个氨基酸取代、约100个氨基酸取代至约115个氨基酸取代、约100个氨基酸取代至约110个氨基酸取代、约100个氨基酸取代至约105个氨基酸取代、约110个氨基酸取代至约160个氨基酸取代、约110个氨基酸取代至约155个氨基酸取代、约110个氨基酸取代至约150个氨基酸取代、约110个氨基酸取代至约145个氨基酸取代、约110个氨基酸取代至约140个氨基酸取代、约110个氨基酸取代至约135个氨基酸取代、约110个氨基酸取代至约130个氨基酸取代、约110个氨基酸取代至约125个氨基酸取代、约110个氨基酸取代至约120个氨基酸取代、约110个氨基酸取代至约115个氨基酸取代、约120个氨基酸取代至约160个氨基酸取代、约120个氨基酸取代至约155个氨基酸取代、约120个氨基酸取代至约150个氨基酸取代、约120个氨基酸取代至约145个氨基酸取代、约120个氨基酸取代至约140个氨基酸取代、约120个氨基酸取代至约135个氨基酸取代、约120个氨基酸取代至约130个氨基酸取代、约120个氨基酸取代至约125个氨基酸取代、约130个氨基酸取代至约160个氨基酸取代、约130个氨基酸取代至约155个氨基酸取代、约130个氨基酸取代至约150个氨基酸取代、约130个氨基酸取代至约145个氨基酸取代、约130个氨基酸取代至约140个氨基酸取代、约130个氨基酸取代至约135个氨基酸取代、约140个氨基酸取代至约160个氨基酸取代、约140个氨基酸取代至约155个氨基酸取代、约140个氨基酸取代至约150个氨基酸取代、约140个氨基酸取代至约145个氨基酸取代、约150个氨基酸取代至约160个氨基酸取代或约150个氨基酸取代至约155个氨基酸取代。本领域技术人员将理解，可对在不同物种的野生型支持细胞靶蛋白或不同物种的野生型毛细胞靶蛋白之间保守的氨基酸进行突变而不会损失活性，然而不应对在不同物种的野生型支持细胞靶蛋白或不同物种的野生型毛细胞靶蛋白之间不保守的那些氨基酸进行突变，因为它们更可能(相较于在不同物种之间不保守的氨基酸)参与活性。

活性靶蛋白(例如，支持细胞靶蛋白或毛细胞靶蛋白)可包含野生型全长靶蛋白(例如，支持细胞靶蛋白(例如，野生型人全长支持细胞靶蛋白)或毛细胞靶蛋白(例如，野生型人全长毛细胞靶蛋白))的序列，所述野生型全长靶蛋白的序列删除了1个氨基酸至约50个氨基酸、1个氨基酸至约45个氨基酸、1个氨基酸至约40个氨基酸、1个氨基酸至约35个氨基酸、1个氨基酸至约30个氨基酸、1个氨基酸至约25个氨基酸、1个氨基酸至约20个氨基酸、1个氨基酸至约15个氨基酸、1个氨基酸至约10个氨基酸、1个氨基酸至约9个氨基酸、1个氨基酸至约8个氨基酸、1个氨基酸至约7个氨基酸、1个氨基酸至约6个氨基酸、1个氨基酸至约5个氨基酸、1个氨基酸至约4个氨基酸、1个氨基酸至约3个氨基酸、约2个氨基酸至约50个氨基酸、约2个氨基酸至约45个氨基酸、约2个氨基酸至约40个氨基酸、约2个氨基酸至约35个氨基酸、约2个氨基酸至约30个氨基酸、约2个氨基酸至约25个氨基酸、约2个氨基酸至约20个氨基酸、约2个氨基酸至约15个氨基酸、约2个氨基酸至约10个氨基酸、约2个氨基酸至约9个氨基酸、约2个氨基酸至约8个氨基酸、约2个氨基酸至约7个氨基酸、约2个氨基酸至约6个氨基酸、约2个氨基酸至约5个氨基酸、约2个氨基酸至约4个氨基酸、约3个氨基酸至约50个氨基酸、约3个氨基酸至约45个氨基酸、约3个氨基酸至约40个氨基酸、约3个氨基酸至约35个氨基酸、约3个氨基酸至约30个氨基酸、约3个氨基酸至约25个氨基酸、约3个氨基酸至约20个氨基酸、约3个氨基酸至约15个氨基酸、约3个氨基酸至约10个氨基酸、约3个氨基酸至约9个氨基酸、约3个氨基酸至约8个氨基酸、约3个氨基酸至约7个氨基酸、约3个氨基酸至约6个氨基酸、约3个氨基酸至约5个氨基酸、约4个氨基酸至约50个氨基酸、约4个氨基酸至约45个氨基酸、约4个氨基酸至约40个氨基酸、约4个氨基酸至约35个氨基酸、约4个氨基酸至约30个氨基酸、约4个氨基酸至约25个氨基酸、约4个氨基酸至约20个氨基酸、约4个氨基酸至约15个氨基酸、约4个氨基酸至约10个氨基酸、约4个氨基酸至约9个氨基酸、约4个氨基酸至约8个氨基酸、约4个氨基酸至约7个氨基酸、约4个氨基酸至约6个氨基酸、约5个氨基酸至约50个氨基酸、约5个氨基酸至约45个氨基酸、约5个氨基酸至约40个氨基酸、约5个氨基酸至约35个氨基酸、约5个氨基酸至约30个氨基酸、约5个氨基酸至约25个氨基酸、约5个氨基酸至约20个氨基酸、约5个氨基酸至约15个氨基酸、约5个氨基酸至约10个氨基酸、约5个氨基酸至约9个氨基酸、约5个氨基酸至约8个氨基酸、约5个氨基酸至约7个氨基酸、约6个氨基酸至约50个氨基酸、约6个氨基酸至约45个氨基酸、约6个氨基酸至约40个氨基酸、约6个氨基酸至约35个氨基酸、约6个氨基酸至约30个氨基酸、约6个氨基酸至约25个氨基酸、约6个氨基酸至约20个氨基酸、约6个氨基酸至约15个氨基酸、约6个氨基酸至约10个氨基酸、约6个氨基酸至约9个氨基酸、约6个氨基酸至约8个氨基酸、约7个氨基酸至约50个氨基酸、约7个氨基酸至约45个氨基酸、约7个氨基酸至约40个氨基酸、约7个氨基酸至约35个氨基酸、约7个氨基酸至约30个氨基酸、约7个氨基酸至约25个氨基酸、约7个氨基酸至约20个氨基酸、约7个氨基酸至约15个氨基酸、约7个氨基酸至约10个氨基酸、约7个氨基酸至约9个氨基酸、约8个氨基酸至约50个氨基酸、约8个氨基酸至约45个氨基酸、约8个氨基酸至约40个氨基酸、约8个氨基酸至约35个氨基酸、约8个氨基酸至约30个氨基酸、约8个氨基酸至约25个氨基酸、约8个氨基酸至约20个氨基酸、约8个氨基酸至约15个氨基酸、约8个氨基酸至约10个氨基酸、约10个氨基酸至约50个氨基酸、约10个氨基酸至约45个氨基酸、约10个氨基酸至约40个氨基酸、约10个氨基酸至约35个氨基酸、约10个氨基酸至约30个氨基酸、约10个氨基酸至约25个氨基酸、约10个氨基酸至约20个氨基酸、约10个氨基酸至约15个氨基酸、约15个氨基酸至约50个氨基酸、约15个氨基酸至约45个氨基酸、约15个氨基酸至约40个氨基酸、约15个氨基酸至约35个氨基酸、约15个氨基酸至约30个氨基酸、约15个氨基酸至约25个氨基酸、约15个氨基酸至约20个氨基酸、约20个氨基酸至约50个氨基酸、约20个氨基酸至约45个氨基酸、约20个氨基酸至约40个氨基酸、约20个氨基酸至约35个氨基酸、约20个氨基酸至约30个氨基酸、约20个氨基酸至约25个氨基酸、约25个氨基酸至约50个氨基酸、约25个氨基酸至约45个氨基酸、约25个氨基酸至约40个氨基酸、约25个氨基酸至约35个氨基酸、约25个氨基酸至约30个氨基酸、约30个氨基酸至约50个氨基酸、约30个氨基酸至约45个氨基酸、约30个氨基酸至约40个氨基酸、约30个氨基酸至约35个氨基酸、约35个氨基酸至约50个氨基酸、约35个氨基酸至约45个氨基酸、约35个氨基酸至约40个氨基酸、约40个氨基酸至约50个氨基酸、约40个氨基酸至约45个氨基酸、约45个氨基酸至约50个氨基酸。在从野生型全长毛细胞靶蛋白的序列中删除两个或更多个氨基酸的一些实施方案中，所述两个或更多个删除的氨基酸在野生型全长蛋白质的序列中可以是连续的。在从野生型全长毛细胞靶蛋白序列中删除两个或更多个氨基酸的其它实例中，所述两个或更多个删除的氨基酸在野生型全长蛋白序列中不是连续的。本领域技术人员将理解，可删除在不同物种的野生型全长毛细胞靶蛋白之间不保守的氨基酸而不会损失活性，然而不应删除在不同物种的野生型全长毛细胞靶蛋白之间保守的那些氨基酸进行突变，因为它们更可能(相较于在不同物种之间不保守的氨基酸)参与活性。

在从野生型全长支持细胞靶蛋白的序列中删除两个或更多个氨基酸的一些实施方案中，所述两个或更多个删除的氨基酸在野生型全长蛋白质的序列中可以是连续的。在从野生型全长支持细胞靶蛋白的序列中删除两个或更多个氨基酸的其它实例中，所述两个或更多个删除的氨基酸在野生型全长蛋白质的序列中不是连续的。本领域技术人员将会理解，可删除在不同物种的野生型全长支持细胞靶蛋白之间不保守的氨基酸而不会损失活性，然而不应删除在不同物种的野生型全长支持细胞靶蛋白之间保守的那些氨基酸，因为它们更有可能(相较于在不同物种之间不保守的氨基酸)参与活性。

在一些实例中，活性靶蛋白(例如，支持细胞靶蛋白或毛细胞靶蛋白)可以例如包含野生型全长靶蛋白(例如，野生型全长支持细胞靶蛋白或野生型全长毛细胞靶蛋白)的序列，所述野生型全长靶蛋白的序列从其N末端除去了1个氨基酸至约100个氨基酸、1个氨基酸至约95个氨基酸、1个氨基酸至约90个氨基酸、1个氨基酸至约85个氨基酸、1个氨基酸至约80个氨基酸、1个氨基酸至约75个氨基酸、1个氨基酸至约70个氨基酸、1个氨基酸至约65个氨基酸、1个氨基酸至约60个氨基酸、1个氨基酸至约55个氨基酸、1个氨基酸至约50个氨基酸、1个氨基酸至约45个氨基酸、1个氨基酸至约40个氨基酸、1个氨基酸至约35个氨基酸、1个氨基酸至约30个氨基酸、1个氨基酸至约25个氨基酸、1个氨基酸至约20个氨基酸、1个氨基酸至约15个氨基酸、1个氨基酸至约10个氨基酸、1个氨基酸至约9个氨基酸、1个氨基酸至约8个氨基酸、1个氨基酸至约7个氨基酸、1个氨基酸至约6个氨基酸、1个氨基酸至约5个氨基酸、1个氨基酸至约4个氨基酸、1个氨基酸至约3个氨基酸、约2个氨基酸至约100个氨基酸、约2个氨基酸至约95个氨基酸、约2个氨基酸至约90个氨基酸、约2个氨基酸至约85个氨基酸、约2个氨基酸至约80个氨基酸、约2个氨基酸至约75个氨基酸、约2个氨基酸至约70个氨基酸、约2个氨基酸至约65个氨基酸、约2个氨基酸至约60个氨基酸、约2个氨基酸至约55个氨基酸、约2个氨基酸至约50个氨基酸、约2个氨基酸至约45个氨基酸、约2个氨基酸至约40个氨基酸、约2个氨基酸至约35个氨基酸、约2个氨基酸至约30个氨基酸、约2个氨基酸至约25个氨基酸、约2个氨基酸至约20个氨基酸、约2个氨基酸至约15个氨基酸、约2个氨基酸至约10个氨基酸、约2个氨基酸至约9个氨基酸、约2个氨基酸至约8个氨基酸、约2个氨基酸至约7个氨基酸、约2个氨基酸至约6个氨基酸、约2个氨基酸至约5个氨基酸、约2个氨基酸至约4个氨基酸、约3个氨基酸至约100个氨基酸、约3个氨基酸至约95个氨基酸、约3个氨基酸至约90个氨基酸、约3个氨基酸至约85个氨基酸、约3个氨基酸至约80个氨基酸、约3个氨基酸至约75个氨基酸、约3个氨基酸至约70个氨基酸、约3个氨基酸至约65个氨基酸、约3个氨基酸至约60个氨基酸、约3个氨基酸至约55个氨基酸、约3个氨基酸至约50个氨基酸、约3个氨基酸至约45个氨基酸、约3个氨基酸至约40个氨基酸、约3个氨基酸至约35个氨基酸、约3个氨基酸至约30个氨基酸、约3个氨基酸至约25个氨基酸、约3个氨基酸至约20个氨基酸、约3个氨基酸至约15个氨基酸、约3个氨基酸至约10个氨基酸、约3个氨基酸至约9个氨基酸、约3个氨基酸至约8个氨基酸、约3个氨基酸至约7个氨基酸、约3个氨基酸至约6个氨基酸、约3个氨基酸至约5个氨基酸、约4个氨基酸至约100个氨基酸、约4个氨基酸至约95个氨基酸、约4个氨基酸至约90个氨基酸、约4个氨基酸至约85个氨基酸、约4个氨基酸至约80个氨基酸、约4个氨基酸至约75个氨基酸、约4个氨基酸至约70个氨基酸、约4个氨基酸至约65个氨基酸、约4个氨基酸至约60个氨基酸、约4个氨基酸至约55个氨基酸、约4个氨基酸至约50个氨基酸、约4个氨基酸至约45个氨基酸、约4个氨基酸至约40个氨基酸、约4个氨基酸至约35个氨基酸、约4个氨基酸至约30个氨基酸、约4个氨基酸至约25个氨基酸、约4个氨基酸至约20个氨基酸、约4个氨基酸至约15个氨基酸、约4个氨基酸至约10个氨基酸、约4个氨基酸至约9个氨基酸、约4个氨基酸至约8个氨基酸、约4个氨基酸至约7个氨基酸、约4个氨基酸至约6个氨基酸、约5个氨基酸至约100个氨基酸、约5个氨基酸至约95个氨基酸、约5个氨基酸至约90个氨基酸、约5个氨基酸至约85个氨基酸、约5个氨基酸至约80个氨基酸、约5个氨基酸至约75个氨基酸、约5个氨基酸至约70个氨基酸、约5个氨基酸至约65个氨基酸、约5个氨基酸至约60个氨基酸、约5个氨基酸至约55个氨基酸、约5个氨基酸至约50个氨基酸、约5个氨基酸至约45个氨基酸、约5个氨基酸至约40个氨基酸、约5个氨基酸至约35个氨基酸、约5个氨基酸至约30个氨基酸、约5个氨基酸至约25个氨基酸、约5个氨基酸至约20个氨基酸、约5个氨基酸至约15个氨基酸、约5个氨基酸至约10个氨基酸、约5个氨基酸至约9个氨基酸、约5个氨基酸至约8个氨基酸、约5个氨基酸至约7个氨基酸、约6个氨基酸至约100个氨基酸、约6个氨基酸至约95个氨基酸、约6个氨基酸至约90个氨基酸、约6个氨基酸至约85个氨基酸、约6个氨基酸至约80个氨基酸、约6个氨基酸至约75个氨基酸、约6个氨基酸至约70个氨基酸、约6个氨基酸至约65个氨基酸、约6个氨基酸至约60个氨基酸、约6个氨基酸至约55个氨基酸、约6个氨基酸至约50个氨基酸、约6个氨基酸至约45个氨基酸、约6个氨基酸至约40个氨基酸、约6个氨基酸至约35个氨基酸、约6个氨基酸至约30个氨基酸、约6个氨基酸至约25个氨基酸、约6个氨基酸至约20个氨基酸、约6个氨基酸至约15个氨基酸、约6个氨基酸至约10个氨基酸、约6个氨基酸至约9个氨基酸、约6个氨基酸至约8个氨基酸、约7个氨基酸至约100个氨基酸、约7个氨基酸至约95个氨基酸、约7个氨基酸至约90个氨基酸、约7个氨基酸至约85个氨基酸、约7个氨基酸至约80个氨基酸、约7个氨基酸至约75个氨基酸、约7个氨基酸至约70个氨基酸、约7个氨基酸至约65个氨基酸、约7个氨基酸至约60个氨基酸、约7个氨基酸至约55个氨基酸、约7个氨基酸至约50个氨基酸、约7个氨基酸至约45个氨基酸、约7个氨基酸至约40个氨基酸、约7个氨基酸至约35个氨基酸、约7个氨基酸至约30个氨基酸、约7个氨基酸至约25个氨基酸、约7个氨基酸至约20个氨基酸、约7个氨基酸至约15个氨基酸、约7个氨基酸至约10个氨基酸、约7个氨基酸至约9个氨基酸、约8个氨基酸至约100个氨基酸、约8个氨基酸至约95个氨基酸、约8个氨基酸至约90个氨基酸、约8个氨基酸至约85个氨基酸、约8个氨基酸至约80个氨基酸、约8个氨基酸至约75个氨基酸、约8个氨基酸至约70个氨基酸、约8个氨基酸至约65个氨基酸、约8个氨基酸至约60个氨基酸、约8个氨基酸至约55个氨基酸、约8个氨基酸至约50个氨基酸、约8个氨基酸至约45个氨基酸、约8个氨基酸至约40个氨基酸、约8个氨基酸至约35个氨基酸、约8个氨基酸至约30个氨基酸、约8个氨基酸至约25个氨基酸、约8个氨基酸至约20个氨基酸、约8个氨基酸至约15个氨基酸、约8个氨基酸至约10个氨基酸、约10个氨基酸至约100个氨基酸、约10个氨基酸至约95个氨基酸、约10个氨基酸至约90个氨基酸、约10个氨基酸至约85个氨基酸、约10个氨基酸至约80个氨基酸、约10个氨基酸至约75个氨基酸、约10个氨基酸至约70个氨基酸、约10个氨基酸至约65个氨基酸、约10个氨基酸至约60个氨基酸、约10个氨基酸至约55个氨基酸、约10个氨基酸至约50个氨基酸、约10个氨基酸至约45个氨基酸、约10个氨基酸至约40个氨基酸、约10个氨基酸至约35个氨基酸、约10个氨基酸至约30个氨基酸、约10个氨基酸至约25个氨基酸、约10个氨基酸至约20个氨基酸、约10个氨基酸至约15个氨基酸、约20个氨基酸至约100个氨基酸、约20个氨基酸至约95个氨基酸、约20个氨基酸至约90个氨基酸、约20个氨基酸至约85个氨基酸、约20个氨基酸至约80个氨基酸、约20个氨基酸至约75个氨基酸、约20个氨基酸至约70个氨基酸、约20个氨基酸至约65个氨基酸、约20个氨基酸至约60个氨基酸、约20个氨基酸至约55个氨基酸、约20个氨基酸至约50个氨基酸、约20个氨基酸至约45个氨基酸、约20个氨基酸至约40个氨基酸、约20个氨基酸至约35个氨基酸、约20个氨基酸至约30个氨基酸、约20个氨基酸至约25个氨基酸、约30个氨基酸至约100个氨基酸、约30个氨基酸至约95个氨基酸、约30个氨基酸至约90个氨基酸、约30个氨基酸至约85个氨基酸、约30个氨基酸至约80个氨基酸、约30个氨基酸至约75个氨基酸、约30个氨基酸至约70个氨基酸、约30个氨基酸至约65个氨基酸、约30个氨基酸至约60个氨基酸、约30个氨基酸至约55个氨基酸、约30个氨基酸至约50个氨基酸、约30个氨基酸至约45个氨基酸、约30个氨基酸至约40个氨基酸、约30个氨基酸至约35个氨基酸、约40个氨基酸至约100个氨基酸、约40个氨基酸至约95个氨基酸、约40个氨基酸至约90个氨基酸、约40个氨基酸至约85个氨基酸、约40个氨基酸至约80个氨基酸、约40个氨基酸至约75个氨基酸、约40个氨基酸至约70个氨基酸、约40个氨基酸至约65个氨基酸、约40个氨基酸至约60个氨基酸、约40个氨基酸至约55个氨基酸、约40个氨基酸至约50个氨基酸、约40个氨基酸至约45个氨基酸、约50个氨基酸至约100个氨基酸、约50个氨基酸至约95个氨基酸、约50个氨基酸至约90个氨基酸、约50个氨基酸至约85个氨基酸、约50个氨基酸至约80个氨基酸、约50个氨基酸至约75个氨基酸、约50个氨基酸至约70个氨基酸、约50个氨基酸至约65个氨基酸、约50个氨基酸至约60个氨基酸、约50个氨基酸至约55个氨基酸、约60个氨基酸至约100个氨基酸、约60个氨基酸至约95个氨基酸、约60个氨基酸至约90个氨基酸、约60个氨基酸至约85个氨基酸、约60个氨基酸至约80个氨基酸、约60个氨基酸至约75个氨基酸、约60个氨基酸至约70个氨基酸、约60个氨基酸至约65个氨基酸、约70个氨基酸至约100个氨基酸、约70个氨基酸至约95个氨基酸、约70个氨基酸至约90个氨基酸、约70个氨基酸至约85个氨基酸、约70个氨基酸至约80个氨基酸、约70个氨基酸至约75个氨基酸、约80个氨基酸至约100个氨基酸、约80个氨基酸至约95个氨基酸、约80个氨基酸至约90个氨基酸、约80个氨基酸至约85个氨基酸、约90个氨基酸至约100个氨基酸、约90个氨基酸至约95个氨基酸或约95个氨基酸至约100个氨基酸并且/或者从其C末端除去了1个氨基酸至100个氨基酸(或本文所述的该范围的任何子范围)。

在一些实施方案中，活性靶蛋白(例如，支持细胞靶蛋白或毛细胞靶蛋白)可以例如包括野生型全长靶蛋白(例如，野生型全长支持细胞靶蛋白或野生型全长毛细胞靶蛋白)的序列，在所述野生型全长靶蛋白的序列中插入了1个氨基酸至50个氨基酸、1个氨基酸至45个氨基酸、1个氨基酸至40个氨基酸、1个氨基酸至35个氨基酸、1个氨基酸至30个氨基酸、1个氨基酸至25个氨基酸、1个氨基酸至20个氨基酸、1个氨基酸至15个氨基酸、1个氨基酸至10个氨基酸、1个氨基酸至9个氨基酸、1个氨基酸至8个氨基酸、1个氨基酸至7个氨基酸、1个氨基酸至6个氨基酸、1个氨基酸至5个氨基酸、1个氨基酸至4个氨基酸、1个氨基酸至3个氨基酸、约2个氨基酸至50个氨基酸、约2个氨基酸至45个氨基酸、约2个氨基酸至40个氨基酸、约2个氨基酸至35个氨基酸、约2个氨基酸至30个氨基酸、约2个氨基酸至25个氨基酸、约2个氨基酸至20个氨基酸、约2个氨基酸至15个氨基酸、约2个氨基酸至10个氨基酸、约2个氨基酸至9个氨基酸、约2个氨基酸至8个氨基酸、约2个氨基酸至7个氨基酸、约2个氨基酸至6个氨基酸、约2个氨基酸至5个氨基酸、约2个氨基酸至4个氨基酸、约3个氨基酸至50个氨基酸、约3个氨基酸至45个氨基酸、约3个氨基酸至40个氨基酸、约3个氨基酸至35个氨基酸、约3个氨基酸至30个氨基酸、约3个氨基酸至25个氨基酸、约3个氨基酸至20个氨基酸、约3个氨基酸至15个氨基酸、约3个氨基酸至10个氨基酸、约3个氨基酸至9个氨基酸、约3个氨基酸至8个氨基酸、约3个氨基酸至7个氨基酸、约3个氨基酸至6个氨基酸、约3个氨基酸至5个氨基酸、约4个氨基酸至50个氨基酸、约4个氨基酸至45个氨基酸、约4个氨基酸至40个氨基酸、约4个氨基酸至35个氨基酸、约4个氨基酸至30个氨基酸、约4个氨基酸至25个氨基酸、约4个氨基酸至20个氨基酸、约4个氨基酸至15个氨基酸、约4个氨基酸至10个氨基酸、约4个氨基酸至9个氨基酸、约4个氨基酸至8个氨基酸、约4个氨基酸至7个氨基酸、约4个氨基酸至6个氨基酸、约5个氨基酸至50个氨基酸、约5个氨基酸至45个氨基酸、约5个氨基酸至40个氨基酸、约5个氨基酸至35个氨基酸、约5个氨基酸至30个氨基酸、约5个氨基酸至25个氨基酸、约5个氨基酸至20个氨基酸、约5个氨基酸至15个氨基酸、约5个氨基酸至10个氨基酸、约5个氨基酸至9个氨基酸、约5个氨基酸至8个氨基酸、约5个氨基酸至7个氨基酸、约6个氨基酸至50个氨基酸、约6个氨基酸至45个氨基酸、约6个氨基酸至40个氨基酸、约6个氨基酸至35个氨基酸、约6个氨基酸至30个氨基酸、约6个氨基酸至25个氨基酸、约6个氨基酸至20个氨基酸、约6个氨基酸至15个氨基酸、约6个氨基酸至10个氨基酸、约6个氨基酸至9个氨基酸、约6个氨基酸至8个氨基酸、约7个氨基酸至50个氨基酸、约7个氨基酸至45个氨基酸、约7个氨基酸至40个氨基酸、约7个氨基酸至35个氨基酸、约7个氨基酸至30个氨基酸、约7个氨基酸至25个氨基酸、约7个氨基酸至20个氨基酸、约7个氨基酸至15个氨基酸、约7个氨基酸至10个氨基酸、约7个氨基酸至9个氨基酸、约8个氨基酸至50个氨基酸、约8个氨基酸至45个氨基酸、约8个氨基酸至40个氨基酸、约8个氨基酸至35个氨基酸、约8个氨基酸至30个氨基酸、约8个氨基酸至25个氨基酸、约8个氨基酸至20个氨基酸、约8个氨基酸至15个氨基酸、约8个氨基酸至10个氨基酸、约10个氨基酸至50个氨基酸、约10个氨基酸至45个氨基酸、约10个氨基酸至40个氨基酸、约10个氨基酸至35个氨基酸、约10个氨基酸至30个氨基酸、约10个氨基酸至25个氨基酸、约10个氨基酸至20个氨基酸、约10个氨基酸至15个氨基酸、约15个氨基酸至50个氨基酸、约15个氨基酸至45个氨基酸、约15个氨基酸至40个氨基酸、约15个氨基酸至35个氨基酸、约15个氨基酸至30个氨基酸、约15个氨基酸至25个氨基酸、约15个氨基酸至20个氨基酸、约20个氨基酸至50个氨基酸、约20个氨基酸至45个氨基酸、约20个氨基酸至40个氨基酸、约20个氨基酸至35个氨基酸、约20个氨基酸至30个氨基酸、约20个氨基酸至25个氨基酸、约25个氨基酸至50个氨基酸、约25个氨基酸至45个氨基酸、约25个氨基酸至40个氨基酸、约25个氨基酸至35个氨基酸、约25个氨基酸至30个氨基酸、约30个氨基酸至50个氨基酸、约30个氨基酸至45个氨基酸、约30个氨基酸至40个氨基酸、约30个氨基酸至35个氨基酸、约35个氨基酸至50个氨基酸、约35个氨基酸至45个氨基酸、约35个氨基酸至40个氨基酸、约40个氨基酸至50个氨基酸、约40个氨基酸至45个氨基酸或约45个氨基酸至约50个氨基酸。在一些实例中，可以将1个氨基酸至50个氨基酸(或其任何子范围)作为连续序列插入野生型全长蛋白质的序列中。在一些实例中，不将1个氨基酸至50个氨基酸(或其任何子范围)作为连续序列插入野生型全长蛋白质的序列中。如本领域中可以理解的，可以将1个氨基酸至50个氨基酸插入野生型全长蛋白质的序列的一部分中，所述野生型全长蛋白质在物种之间不是非常保守的。

除非另有限定，否则本文中所使用的所有技术和科学术语具有与本发明所属的领域内的普通技术人员通常理解的意义相同的意义。本文描述了用于本发明的方法和材料；还可使用本领域已知的其他合适的方法和材料。所述材料、方法和实例仅是说明性的而不是意图进行限制。本文引用的所有公布、专利申请、专利、序列、数据库条目和其它参考文献通过引用以其整体并入本文。在有冲突的情况下，将以本说明书(包括定义)为准。

附图说明

图1A是在通过圆形窗口将单个Anc80-GFP AAV载体直接施用于内耳后，食蟹猕猴(非人灵长类动物)的耳蜗组织的Myo7a/Iba-1免疫荧光染色的代表性图像。

图1B是与图1A中相同的食蟹猕猴的耳蜗组织的Anc80-GFP免疫荧光染色的代表性图像。

图1C是与图1A中相同的食蟹猕猴的耳蜗组织的Myo7a/Iba-1和Anc80-GFP的合并的免疫荧光染色的代表性图像。

具体实施方式

本文提供了包含至少两种不同的核酸载体的组合物，其中：所述至少两种不同的腺相关病毒(AAV)载体中的每一种均包含编码序列，所述编码序列编码支持细胞靶蛋白的不同部分，所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分中的每一个的氨基酸序列可以任选地与所述编码的部分中的不同的一个部分的氨基酸序列部分地重叠；所述至少两种不同的载体中单一载体均不编码全长支持细胞靶蛋白；所述编码序列中的至少一个包含跨越支持细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述两个相邻外显子之间缺乏内含子序列；以及所述至少两种不同的载体，当被引入到灵长类动物细胞中时，经历彼此串联或同源重组，从而形成编码全长支持细胞靶蛋白的重组核酸。

本文提供了包含两种不同的核酸载体的组合物，其中：所述两种不同的核酸载体中的第一核酸载体包含启动子、位于所述启动子的3’的编码支持细胞靶蛋白的N末端部分的第一编码序列和位于所述第一编码序列的3’末端的剪接供体信号序列；以及所述两种不同的核酸载体中的第二核酸载体包含剪接受体信号序列、位于所述剪接受体信号序列的3'末端的编码支持细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多聚腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的氨基酸序列不重叠，其中所述两种不同的载体中单一载体均不编码所述全长支持细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长支持细胞靶蛋白的重组RNA分子。

本文提供了组合物，其包含：第一核酸载体，其包含启动子、位于所述启动子的3'的编码支持细胞靶蛋白的N末端部分的第一编码序列、位于所述第一编码序列的3’末端的剪接供体信号序列，和位于所述剪接供体信号序列的3’的第一可检测标记基因；和第二核酸载体，其与所述第一核酸载体不同，包含第二可检测标记基因、位于所述第二可检测标记基因的3’的剪接受体信号序列、位于所述剪接受体信号序列的3’末端的编码支持细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的各自的氨基酸序列彼此不重叠，其中所述两种不同的载体中单一载体均不编码所述全长支持细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长支持细胞靶蛋白的重组RNA分子。

本文还提供了组合物，其包含：第一核酸载体，其包含启动子、位于所述启动子的3'的编码支持细胞靶蛋白的N末端部分的第一编码序列、位于所述第一编码序列的3’末端的剪接供体信号序列，和位于所述剪接供体信号序列的3’的F1噬菌体重组发生区；和第二核酸载体，其与所述第一核酸载体不同，包含第二F1噬菌体重组发生区、位于所述第二F1噬菌体重组发生区的3’的剪接受体信号序列、位于所述剪接受体信号序列的3’末端的编码支持细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的各自的氨基酸序列彼此不重叠，其中所述两种不同的载体中单一载体均不编码所述全长支持细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长支持细胞靶蛋白的重组RNA分子。

本文提供了包含单一腺相关病毒(AAV)载体的组合物，其中所述单一AAV载体包含编码支持细胞靶蛋白的核酸序列；以及当被引入到灵长类动物细胞中时，在支持细胞靶基因的基因座处产生编码全长支持细胞靶蛋白的核酸，并且所述灵长类动物表达所述支持细胞靶蛋白。

本文提供了包含至少两种不同的核酸载体的组合物，其中：所述至少两种不同的腺相关病毒(AAV)载体中的每一种均包含编码序列，所述编码序列编码毛细胞靶蛋白的不同部分，所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分中的每一个的氨基酸序列可以任选地与所述编码的部分中的不同的一个部分的氨基酸序列部分地重叠；所述至少两种不同的载体中单一载体均不编码全长毛细胞靶蛋白；所述编码序列中的至少一个包含跨越毛细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述两个相邻外显子之间缺乏内含子序列；以及所述至少两种不同的载体，当被引入到灵长类动物细胞中时，经历彼此串联或同源重组，从而形成编码全长毛细胞靶蛋白的重组核酸。

本文提供了包含两种不同的核酸载体的组合物，其中：所述两种不同的核酸载体中的第一核酸载体包含启动子、位于所述启动子的3’的编码毛细胞靶蛋白的N末端部分的第一编码序列和位于所述第一编码序列的3’末端的剪接供体信号序列；以及所述两种不同的核酸载体中的第二核酸载体包含剪接受体信号序列、位于所述剪接受体信号序列的3'末端的编码毛细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多聚腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的氨基酸序列不重叠，其中所述两种不同的载体中单一载体均不编码所述全长毛细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长毛细胞靶蛋白的重组RNA分子。

本文提供了组合物，其包含：第一核酸载体，其包含启动子、位于所述启动子的3’的编码毛细胞靶蛋白的N末端部分的第一编码序列、位于所述第一编码序列的3’末端的剪接供体信号序列，和位于所述剪接供体信号序列的3’的第一可检测标记基因；和第二核酸载体，其与所述第一核酸载体不同，包含第二可检测标记基因、位于所述第二可检测标记基因的3’的剪接受体信号序列、位于所述剪接受体信号序列的3’末端的编码毛细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的各自的氨基酸序列彼此不重叠，其中所述两种不同的载体中单一载体均不编码所述全长毛细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长毛细胞靶蛋白的重组RNA分子。

本文提供了组合物，其包含：第一核酸载体，其包含启动子、位于所述启动子的3’的编码毛细胞靶蛋白的N末端部分的第一编码序列、位于所述第一编码序列的3’末端的剪接供体信号序列和位于所述剪接供体信号序列的3’的F1噬菌体重组发生区；和第二核酸载体，其与所述第一核酸载体不同，包含第二F1噬菌体重组发生区、位于所述第二F1噬菌体重组发生区的3’的剪接受体信号序列、位于所述剪接受体信号序列的3’末端的编码毛细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的各自的氨基酸序列彼此不重叠，其中所述两种不同的载体中单一载体均不编码所述全长毛细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的剪接供体信号与另一个转录物上的剪接受体信号之间发生剪接，从而形成编码全长毛细胞靶蛋白的重组RNA分子。

本文还提供了包含单一腺相关病毒(AAV)载体的组合物，其中所述单一AAV载体包含编码毛细胞靶蛋白的核酸序列；并且当被引入到灵长类动物细胞时，在所述毛细胞靶基因的基因座处产生编码全长毛细胞靶蛋白的核酸，并且所述灵长类动物表达所述毛细胞靶蛋白。

还提供了包括本文所述的任何组合物的试剂盒。本文还提供了包括向哺乳动物的耳蜗施用治疗有效量的本文所述的任何组合物的方法。

还提供了校正灵长类动物内耳的支持细胞中的支持细胞靶基因缺陷的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物，其中所述施用修复所述灵长类动物内耳的支持细胞中的支持细胞靶基因缺陷。

还提供了校正灵长类动物内耳的毛细胞中的毛细胞靶基因缺陷的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物，其中所述施用修复所述灵长类动物内耳的毛细胞中的毛细胞靶基因缺陷。

本文还提供了升高灵长类动物内耳的支持细胞中的支持细胞靶蛋白的表达水平的方法，所述方法包括向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物，其中所述施用使得所述灵长类动物内耳的支持细胞中的所述支持细胞靶蛋白的表达水平升高。

本文还提供了升高灵长类动物内耳的毛细胞中的毛细胞靶蛋白的表达水平的方法，所述方法包括向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物，其中所述施用使得所述灵长类动物内耳的所述毛细胞中的所述毛细胞靶蛋白的表达水平升高。

本文还提供了治疗被鉴定为具有缺陷型支持细胞靶基因的灵长类动物的听力损失，例如非综合征性感音神经性听力损失或综合征性感音神经性听力损失的方法，所述方法包括：向灵长类动物的内耳施用治疗有效量的本文所述的任何组合物。

本文还提供了治疗被鉴定为具有缺陷型毛细胞靶基因的灵长类动物的听力损失(例如非综合征性感音神经性听力损失或综合征性感音神经性听力损失)的方法，所述方法包括：向灵长类动物的内耳施用治疗有效量的本文所述的任何组合物。

本文还提供了恢复被鉴定或诊断为听力损失的灵长类动物的听力的方法，所述方法包括：向灵长类动物的内耳施用治疗有效量的本文所述的任何组合物。

本文还提供了恢复被鉴定或诊断为患有内耳病症的灵长类动物的突触并且/或者保存其螺旋神经节神经的方法，所述方法包括：向灵长类动物的内耳施用治疗有效量的本文所述的任何组合物。

本文还提供了包括向灵长类动物的内耳施用治疗有效量的本文所述的任何组合物的方法。

组合物、试剂盒和方法的其它非限制性方面在本文中进行了描述，并且可以以任意组合使用而不受限制。

缝隙连接蛋白β2(GJB2)

GJB2基因编码缝隙连接蛋白β2(缝隙连接蛋白家族的成员)。缝隙连接蛋白是参与细胞内通讯的专门蛋白，也称为连结蛋白。GJB2中的突变已与听力损失和耳聋相关联(Amorini等人，Ann.Hum.Genet.79(5):341-349,2015；Qing等人，Genet.TestMol.Biomarkers 19(1):52-58,2015)。

人GJB2基因位于染色体13q12上。其包含2个外显子，涵盖约5千碱基(kb)(NCBI登录号NG008358.1)。从人GJB2基因表达的全长野生型GJB2蛋白的长度为226个氨基酸。

GJB2基因中的各种突变与听力损失(例如，非综合征性感音神经性听力损失或综合征性感音神经性听力损失)相关联。例如，在65.5％的来自西西里岛东部的患者中发现c.35delG等位基因(Amorini等人，Ann.Hum.Genet.79(5):341-349,2015)。

在患有非综合征性感音神经性听力损失或综合征性感音神经性听力损失的受试者中检测到的GJB2基因中的其它示例性突变，以及对编码GJB2的核酸进行测序的方法描述于例如Snoeckx等人，Am.J.Hum.Genet 77:945-957,2005；Welch等人，Am.J.Med.Genet A143:1567-1573,2007；和Zelante等人，Hum.Mol.Genet.6:1605-1609,1997中。检测基因中的突变的方法是本领域公知的。此类技术的非限制性实例包括：实时聚合酶链式反应(RT-PCR)、PCR、测序、Southern印迹和Northern印迹。

示例性人野生型GJB2蛋白为或包括SEQ ID NO:1的序列。编码野生型GJB2蛋白的核酸的非限制性实例为或包括SEQ ID NO:2。如在本领域中可以理解的，可对SEQ ID NO:2中的至少一些或全部密码子进行密码子优化以允许在非人哺乳动物中的最佳表达。

在本文所述的任何组合物的一些实施方案中，GJB2蛋白包含与SEQ ID NO:1具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。

人全长野生型GJB2蛋白(SEQ ID NO:1)

MDWGTLQTILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPGCKNVCYDHYFPISHIRLWALQLIFVSTPALLVAMHVAYRRHEKKRKFIKGEIKSEFKDIEEIKTQKVRIEGSLWWTYTSSIFFRVIFEAAFMYVFYVMYDGFSMQRLVKCNAWPCPNTVDCFVSRPTEKTVFTVFMIAVSGICILLNVTELCYLLIRYCSGKSKKPV

人野生型GJB2 cDNA(SEQ ID NO:2)

atggattggggcacgctgcagacgatcctggggggtgtgaacaaacactccaccagcattggaaagatctggctcaccgtcctcttcatttttcgcattatgatcctcgttgtggctgcaaaggaggtgtggggagatgagcaggccgactttgtctgcaacaccctgcagccaggctgcaagaacgtgtgctacgatcactacttccccatctcccacatccggctatgggccctgcagctgatcttcgtgtccacgccagcgctcctagtggccatgcacgtggcctaccggagacatgagaagaagaggaagttcatcaagggggagataaagagtgaatttaaggacatcgaggagatcaaaacccagaaggtccgcatcgaaggctccctgtggtggacctacacaagcagcatcttcttccgggtcatcttcgaagccgccttcatgtacgtcttctatgtcatgtacgacggcttctccatgcagcggctggtgaagtgcaacgcctggccttgtcccaacactgtggactgctttgtgtcccggcccacggagaagactgtcttcacagtgttcatgattgcagtgtctggaatttgcatcctgctgaatgtcactgaattgtgttatttgctaattagatattgttctgggaagtcaaaaaagccagtttaa

人野生型GJB2基因组DNA序列的非限制性实例是SEQ ID NO:3。SEQ ID NO:3中的外显子是：核苷酸位置1-156(外显子1)和核苷酸位置3336-5469(外显子2)。内含子位于SEQID NO:3中的这些外显子中的每一个之间，即，在核苷酸位置157-3335处(内含子1)。

人野生型GJB2基因序列(SEQ ID NO:3)(NCBI参考序列：NG_008358.1)

1 ggggtgcggt taaaaggcgc cacggcggga gacaggtgtt gcggccccgc agcgcccgcg61cgctcctctc cccgactcgg agcccctcgg cggcgcccgg cccaggaccc gcctaggagc 121gcaggagccc cagcgcagag accccaacgc cgagaccccc gccccggccc cgccgcgctt 181cctcccgacg caggtgagcc cgccggcccc ggactgcccg gccaggaacc tggcgcgggg 241agggaccgcg agacccagag cggttgcccg gccgcgtggg tctcggggaa ccggggggct 301ggaccaacac acgtccttgg gccggggggc gggggccgcc ttctggagcg ggcgtttctg 361cggccgagct ccggagctgg aatggggcgg ccggggaagt ggacgcgatg gcaccgcccg 421gggtgcgagt ggggccgggc gcgcgcggga ggggaaaaag gcgcgggcga gccgccagcg 481cgaggtttgt ggtgtcgccg atgtcccttc ggggtactct agcgcagccg cctggctact 541tgacccactg ccaccaaacg ttttaaattc accgaaagct tagcttcgaa gcaaagctcc 601gtttcgccgg tgaagcagga agccttcgct gcaggaactg acctttacct cttggagcgg 661cttctgcaga aaaatccccg ggcagagatt tgggcggagt ttgcctagaa ctaacgcgga 721gccagccgat cccggcctac cccggggcca agatttcagt ggcttccctt tttcctaaac 781acttcacgag ggtctgtttc cgggctgtgc tccccgccta gaaggaaaat ttttaggacc 841cttgttcgcg aagaggtggt gtgcggctga gacccgcgtc ctcaggacgg ttccatcagt 901gcctcgatcc tgccccactg gaggaggaag gcagcccgaa cagcgctcac ctaactaaca 961gctgctgaga gctgggttcc gtggccatgc acctgggact gccttgagaa gcgtggtacg 1021gccgtgtccc catgtgacct tagagtccct ttcgaaactg ctgtgcacag tcggtcacaa 1081tttcagacac tggtgagaag ggtggaggaa ccctctgggg acagccaggc aaggtcgacc 1141acccatcacc taagggtgga gaaatttaag gggtgaagag tcccttttgc cttttctgga 1201tcctggtgat tcacctagtg tcttccctaa ggaactgaac caactcctcc gctggcctct 1261ggcagccctc caggcggtgc aggatggcgt gggcccggta ggaagctgca tgtaaccgcc 1321cagggtcggg aggccaggag ggcagctcct cctctgactt gaatattgaa aacaacttcg 1381tcctgcttct gagcccctct taacccatga ccccctagcc cattggggag taaatcttaa 1441tttactcctc ttcctgaaaa aggatcttta aaacaggtag cttcaactca agctttataa 1501aataacaata tagggtttct cggaactgta tttttctcag ctgatggtaa ctggacaggt 1561ctgtagaagg gtgtatgacc tgggtttggc aggtggaaga gggcaaagga taaacccctc 1621ctcctgcagc cccatattct tggccaggtg tattgttgta aaccaggaga gagtttactt 1681cggggagtat cctgttttcc actcagtgag ggccaatgaa gaatgtctaa ttccataaga 1741tgcttttgtt aaaatcggaa tgttgctgtc ctcggtggtt ctgctgttgg gacgggactg 1801gcctgagctg tgggtgctgt agcaggacaa ccagctcacc taagggcctc ccagtctgga 1861ttatcaatgg gtcagtgctg aacctgggct aaaatattgt tttttccaat gatgttgtct 1921ttcccaagct cagtgaagct aaatgtttca caggcctatg tcaatctgat gtaactttcg 1981tggccacctc tctcctgtta gcctctgacc aaggtggcac tggatggttt ctgcctgacc 2041ttggtgcccc gtggcagcga ctgtgggtca tgaaagacat tcactacgag cctgcttctg 2101gagtccatca gaaaacggga tgcaacttgc ctaaaatgag gagaggagga tgcttttaag 2161aaaaagaaga aggaggattc actaccagct ctgaagggtg gaaaagagat gattcatccg 2221gattgtggag agggtggaat cttgtttagg agagcgttgg ttgtggcagg cagggtgtaa 2281ctatgaatca gtgaagacaa ttcacatcct gggatgaaaa gaaggccatg ggctcacagg 2341agattatcca ctggcctctc cacatccgct tgcagtaagg agtgtgggac tctcccaagc 2401ttcagcgctg aactgcaatg cagtgacgtc gcttagctgg gccagtaacc gagggagttg 2461aattttctgt cattttaaaa taatgtgtct tttaagaaac actttgaaat taaaaccaca 2521gcccacaatt ataatgcact gttgcagcac ttatcaaaac agatatgcta actgagccat 2581cagtgccagc ctgacagtga ggccaccaag ccatccacaa agcctacacg aaagtctgtg 2641ctcacagtgg cttttctcca tgaagagggc attcctaacc tcttcctttc acgtaggagg 2701aagcaaggtc ctttgtaaaa ttttaactcg gggtgcctca aatgtaaact taaccactgg 2761taacaacagt ttcactgcta catgccacgt ctgtgaaaat tcattcaaga cattaaggaa 2821agtggctcag cagagagact agacatctta tcctcacggt tctcctgtac ttggcctctc 2881agcctttgag caaggttggc ccaagctagt atcggcccca gtggtacagc caaaacttga 2941gactgcaaat ggatgcagct gttgaacgct gagtaacttc tgcagagtca ggaagaccca 3001aggaagctct gcagaggatg caggggtacg gtcagaaccc ctgagtgcct ttcagctaac 3061gaggacttta tgacactccc cagcacagca aatttttatg atgtgtttaa agattgggtg 3121aattactcag gtgaacaagc tactttttat cagagaacac ctaaaaacac gttcaagagg 3181gtttgggaac tatacattta atcctatgac aaactaagtt ggttctgtct tcacctgttt 3241tggtgaggtt gtgtaagagt tggtgtttgc tcaggaagag atttaagcat gcttgcttac 3301ccagactcag agaagtctcc ctgttctgtc ctagctagtg attcctgtgt tgtgtgcatt 3361cgtcttttcc agagcaaacc gcccagagta gaagatggat tggggcacgc tgcagacgat 3421cctggggggt gtgaacaaac actccaccag cattggaaag atctggctca ccgtcctctt 3481catttttcgc attatgatcc tcgttgtggc tgcaaaggag gtgtggggag atgagcaggc 3541cgactttgtc tgcaacaccc tgcagccagg ctgcaagaac gtgtgctacg atcactactt 3601ccccatctcc cacatccggc tatgggccct gcagctgatc ttcgtgtcca cgccagcgct 3661cctagtggcc atgcacgtgg cctaccggag acatgagaag aagaggaagt tcatcaaggg 3721ggagataaag agtgaattta aggacatcga ggagatcaaa acccagaagg tccgcatcga 3781aggctccctg tggtggacct acacaagcag catcttcttc cgggtcatct tcgaagccgc 3841cttcatgtac gtcttctatg tcatgtacga cggcttctcc atgcagcggc tggtgaagtg 3901caacgcctgg ccttgtccca acactgtgga ctgctttgtg tcccggccca cggagaagac 3961tgtcttcaca gtgttcatga ttgcagtgtc tggaatttgc atcctgctga atgtcactga 4021attgtgttat ttgctaatta gatattgttc tgggaagtca aaaaagccag tttaacgcat 4081tgcccagttg ttagattaag aaatagacag catgagaggg atgaggcaac ccgtgctcag 4141ctgtcaaggc tcagtcgcta gcatttccca acacaaagat tctgacctta aatgcaacca 4201tttgaaaccc ctgtaggcct caggtgaaac tccagatgcc acaatggagc tctgctcccc 4261taaagcctca aaacaaaggc ctaattctat gcctgtctta attttctttc acttaagtta 4321gttccactga gaccccaggc tgttaggggt tattggtgta aggtactttc atattttaaa 4381cagaggatat cggcatttgt ttctttctct gaggacaaga gaaaaaagcc aggttccaca 4441gaggacacag agaaggtttg ggtgtcctcc tggggttctt tttgccaact ttccccacgt 4501taaaggtgaa cattggttct ttcatttgct ttggaagttt taatctctaa cagtggacaa 4561agttaccagt gccttaaact ctgttacact ttttggaagt gaaaactttg tagtatgata 4621ggttattttg atgtaaagat gttctggata ccattatatg ttccccctgt ttcagaggct 4681cagattgtaa tatgtaaatg gtatgtcatt cgctactatg atttaatttg aaatatggtc 4741ttttggttat gaatactttg cagcacagct gagaggctgt ctgttgtatt cattgtggtc 4801atagcaccta acaacattgt agcctcaatc gagtgagaca gactagaagt tcctagtgat 4861ggcttatgat agcaaatggc ctcatgtcaa atatttagat gtaattttgt gtaagaaata 4921cagactggat gtaccaccaa ctactacctg taatgacagg cctgtccaac acatctccct 4981tttccatgac tgtggtagcc agcatcggaa agaacgctga tttaaagagg tcgcttggga 5041attttattga cacagtacca tttaatgggg aggacaaaat ggggcagggg agggagaagt 5101ttctgtcgtt aaaaacagat ttggaaagac tggactctaa agtctgttga ttaaagatga 5161gctttgtcta cttcaaaagt ttgtttgctt accccttcag cctccaattt tttaagtgaa 5221aatatagcta ataacatgtg aaaagaatag aagctaaggt ttagataaat attgagcaga 5281tctataggaa gattgaacct gaatattgcc attatgcttg acatggtttc caaaaaatgg 5341tactccacat atttcagtga gggtaagtat tttcctgttg tcaagaatag cattgtaaaa 5401gcattttgta ataataaaga atagctttaa tgatatgctt gtaactaaaa taattttgta 5461atgtatcaaa tacatttaaa acattaaaat ataatctcta taataattta aaa

溶质载体家族26成员4(SLC26A4)

SLC26A4基因编码Pendred蛋白，并且与硫酸盐转运蛋白具有同源性。SLC26A4中的突变与听力损失和耳聋相关联(Albert等人，Eur.J.Hum.Genet.14:773-779,2006；和Qing等人，Genet.Test Mol.Biomarkers 19(1):52-58,2015)。

人SLC26A4基因位于染色体7q22上。其包含21个外显子，涵盖约57千碱基(kb)(NCBI登录号NG_008489.1)。从人SLC26A4基因表达的全长野生型SLC26A4蛋白的长度为780个氨基酸。

SLC26A4基因的各种突变与听力损失相关联。例如，在患有非综合征性听力损失的中国和美国患者中，已经报道了点突变V250A、D266N、E303Q、F345S、D697、K715N和E737D(Dai等人，Physiol Genomics 38(3):281-290,2015)。

在患有非综合征性感音神经性听力损失或综合征性感音神经性听力损失的受试者中检测到的SLC26A4基因的其它示例性突变，以及对编码SLC26A4的核酸进行测序的方法描述于例如Albert等人，Eur.J.Hum.Genet.14:773-779,2006；和Qing等人，Genet.TestMol.Biomarkers 19(1):52-58,2015中。检测基因中的突变的方法是本领域公知的。此类技术的非限制性实例包括：实时聚合酶链式反应(RT-PCR)、PCR、测序、Southern印迹和Northern印迹。

示例性人野生型SLC26A4蛋白为或包括SEQ ID NO:4的序列。编码野生型SLC26A4蛋白的核酸的非限制性实例为或包括SEQ ID NO:5或6.如在本领域中可理解的，可对SEQID NO:5或6中的至少一些或全部密码子进行密码子优化以允许在非人哺乳动物中的最佳表达。

在本文所述的任何组合物的一些实施方案中，所述SLC26A4蛋白包含与SEQ IDNO:4具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。

人全长野生型SLC26A4蛋白(SEQ ID NO:4)

MAAPGGRSEPPQLPEYSCSYMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFLTVHDAILYLQNQVKSQEGQGSILETITLIQDCKDTLELIETELTEEELDVQDEAMRTLAS

示例性人野生型SLC26A4 cDNA(SEQ ID NO:5)

atggcagcgccaggcggcaggtcggagccgccgcagctccccgagtacagctgcagctacatggtgtcgcggccggtctacagcgagctcgctttccagcaacagcacgagcggcgcctgcaggagcgcaagacgctgcgggagagcctggccaagtgctgcagttgttcaagaaagagagcctttggtgtgctaaagactcttgtgcccatcttggagtggctccccaaataccgagtcaaggaatggctgcttagtgacgtcatttcgggagttagtactgggctagtggccacgctgcaagggatggcatatgccctactagctgcagttcctgtcggatatggtctctactctgcttttttccctatcctgacatactttatctttggaacatcaagacatatctcagttggaccttttcca

gtggtgagtttaatggtgggatctgttgttctgagcatggcccccgacgaacactttctcgtatccagcagcaatggaactgtattaaatactactatgatagacactgcagctagagatacagctagagtcctgattgccagtgccctgactctgctggttggaattatacagttgatatttggtggcttgcagattggattcatagtgaggtacttggcagatcctttggttggtggcttcacaacagctgctgccttccaagtgctggtctcacagctaaagattgtcctcaatgtttcaaccaaaaactacaatggagttctctctattatctatacgctggttgagatttttcaaaatattggtgataccaatcttgctgatttcactgctggattgctcaccattgtcgtctgtatggcagttaaggaattaaatgatcggtttagacacaaaatcccagtccctattcctatagaagtaattgtgacgataattgctactgccatttcatatggagccaacctggaaaaaaattacaatgctggcattgttaaatccatcccaagggggtttttgcctcctgaacttccacctgtgagcttgttctcggagatgctggctgcatcattttccatcgctgtggtggcttatgctattgcagtgtcagtaggaaaagtatatgccaccaagtatgattacaccatcgatgggaaccaggaattcattgcctttgggatcagcaacatcttctcaggattcttctcttgttttgtg

gccaccactgctctttcccgcacggccgtccaggagagcactggaggaaagacacaggttgctggcatcatctctgctgcgattgtgatgatcgccattcttgccctggggaagcttctggaacccttgcagaagtcggtcttggcagctgttgtaattgccaacctgaaagggatgtttatgcagctgtgtgacattcctcgtctgtggagacagaataagattgatgctgttatctgggtgtttacgtgtatagtgtccatcattctggggctggatctcggtttactagctggccttatatttggactgttgactgtggtcctgagagttcagtttccttcttggaatggccttggaagcatccctagcacagatatctacaaaagtaccaagaattacaaaaacattgaagaacctcaaggagtgaagattcttagattttccagtcctattttctatggcaatgtcgatggttttaaaaaatgtatcaagtccacagttggatttgatgccattagagtatataataagaggctgaaagcgctgaggaaaatacagaaactaataaaaagtggacaattaagagcaacaaagaatggcatcataagtgatgctgtttcaacaaataatgcttttgagcctgatgaggatattgaagatctggaggaacttgatatcccaaccaaggaaatagagattcaagtggattggaactctgagcttccagtcaaagtgaacgttcccaaagtgccaatccatagccttgtgcttgactgtggagctatatctttcctggacgttgttggagtgagatcactgcgggtgattgtcaaagaattccaaagaattgatgtgaatgtgtattttgcatcacttcaagattatgtgatagaaaagctggagcaatgcgggttctttgacgacaacattagaaaggacacattctttttgacggtccatgatgctatactctatctacagaaccaagtgaaatctcaagagggtcaaggttccattttagaaacgatcactctcattcaggattgtaaagatacccttgaattaatagaaacagagctgacggaagaagaacttgatgtccaggatgaggctatgcgtacacttgcatcctga

示例性人野生型SLC26A4 cDNA(SEQ ID NO:6)

ctcagccttcccggttcgggaaaggggaagaatgcaggaggggtaggatttctttcctgataggatcggttgggaaagaccgcagcctgtgtgtgtctttcccttcgaccaaggtgtctgttgctccgtaaataaaacgtcccactgccttctgagagcgctataaaggcagcggaagggtagtccgcggggcattccgggcggggcgcgagcagagacaggtcatggcagcgccaggcggcaggtcggagccgccgcagctccccgagtacagctgcagctacatggtgtcgcggccggtctacagcgagctcgctttccagcaacagcacgagcggcgcctgcaggagcgcaagacgctgcgggagagcctggccaagtgctgcagttgttcaagaaagagagcctttggtgtgctaaagactcttgtgcccatcttggagtggctccccaaataccgagtcaaggaatggctgcttagtgacgtcatttcgggagttagtactgggctagtggccacgctgcaagggatggcatatgccctactagctgcagttcctgtcggatatggtctctactctgcttttttccctatcctgacatactttatctttggaacatcaagacatatctcagttggaccttttccagtggtgagtttaatggtgggatctgttgttctgagcatggcccccgacgaacactttctcgtatccagcagcaatggaactgtattaaatactactatgatagacactgcagctagagatacagctagagtcctgattgccagtgccctgactctgctggttggaattatacagttgatatttggtggcttgcagattggattcatagtgaggtacttggcagatcctttggttggtggcttcacaacagctgctgccttccaagtgctggtctcacagctaaagattgtcctcaatgtttcaaccaaaaactacaatggagttctctctattatctatacgctggttgagatttttcaaaatattggtgataccaatcttgctgatttcactgctggattgctcaccattgtcgtctgtatggcagttaaggaattaaatgatcggtttagacacaaaatcccagtccctattcctatagaagtaattgtgacgataattgctactgccatttcatatggagccaacctggaaaaaaattacaatgctggcattgttaaatccatcccaagggggtttttgcctcctgaacttccacctgtgagcttgttctcggagatgctggctgcatcattttccatcgctgtggtggcttatgctattgcagtgtcagtaggaaaagtatatgccaccaagtatgattacaccatcgatgggaaccaggaattcattgcctttgggatcagcaacatcttctcaggattcttctcttgttttgtggccaccactgctctttcccgcacggccgtccaggagagcactggaggaaagacacaggttgctggcatcatctctgctgcgattgtgatgatcgccattcttgccctggggaagcttctggaacccttgcagaagtcggtcttggcagctgttgtaattgccaacctgaaagggatgtttatgcagctgtgtgacattcctcgtctgtggagacagaataagattgatgctgttatctgggtgtttacgtgtatagtgtccatcattctggggctggatctcggtttactagctggccttatatttggactgttgactgtggtcctgagagttcagtttccttcttggaatggccttggaagcatccctagcacagatatctacaaaagtaccaagaattacaaaaacattgaagaacctcaaggagtgaagattcttagattttccagtcctattttctatggcaatgtcgatggttttaaaaaatgtatcaagtccacagttggatttgatgccattagagtatataataagaggctgaaagcgctgaggaaaatacagaaactaataaaaagtggacaattaagagcaacaaagaatggcatcataagtgatgctgtttcaacaaataatgcttttgagcctgatgaggatattgaagatctggaggaacttgatatcccaaccaaggaaatagagattcaagtggattggaactctgagcttccagtcaaagtgaacgttcccaaagtgccaatccatagccttgtgcttgactgtggagctatatctttcctggacgttgttggagtgagatcactgcgggtgattgtcaaagaattccaaagaattgatgtgaatgtgtattttgcatcacttcaagattatgtgatagaaaagctggagcaatgcgggttctttgacgacaacattagaaaggacacattctttttgacggtccatgatgctatactctatctacagaaccaagtgaaatctcaagagggtcaaggttccattttagaaacgatcactctcattcaggattgtaaagatacccttgaattaatagaaacagagctgacggaagaagaacttgatgtccaggatgaggctatgcgtacacttgcatcctgaaagtgggttcgggaggtctctatgagcaaggaatacaagacaaaacttcctcaatgcattgactatttcttcagactcaaaacactcattcttttttctattaagccattgaaagagaagcactaagactgcttctaggctttatttataaaataaacaccttatccctaacatgggcaaaatggctagaattattcagacgatttggcagcgtccagggtaagctggtgttataatacgctgctgatctacatcacagatttgctaataatgttcacgtgggccctggcatatctctgttcagttagagtgagtgctgacccaacagcctctgtggtcaagcgagtcacgaatgattaatcataaagaaaaatcagtttttgactgacctggatatccatgagctgcactgatcaccatgtaaggtcacatttagtaaatgctgaaataaaatgattaatgcatttatcaataaaagcctttgaaaatactttggataataaattggagttttaaaaatgcaaatttgcttagtatctaataatgaagtgttattacatatagccggaattgaggatctctttgatcctggaaatggtttacctaaaagctacagaaccaggccaatatattttgaaatattgatgcagacaaatgaaataataaagagattttcatggtttataaaaatcttttttgatatgataataatcatgatcacaactgagatcaaaaaaatatatgacagattattttgtttaaaaatgcagttttaattatcttagtctatagaaatgatcattgcatggaggcatgtataggtatgatctgtgtaaaatctgacataaaaacagtgctattctgagtgaaaatttttttgatgtgcttacataaccatggtgattaaaatgagtttatattttttctcaaaaattttagcagtgtgtaaagtaagtaatctttaactgaactctgaccacttaaaaaaaaatctaaaaattgaactacctatagtagtctgtgtttaaagtgaatttttaaagacaaagcattctaaatgaactcaatataaaaacattcatttggaatgtacatactgaaaaatacaggtttttttgaccaaaagtttttatatcttttctttttatttatttttttcctaagtgccaacaattttctagatattatatacaacacaggctttgatcttggggacttttcccatatatttcacactggagtgaatgaagttgtacttcatttctagagaaaagttatacccaggtccccaattgagaatgtcttgcttgattgaaaacgacatcatcccttggtatactccagggattggtttcaggacccctgcatttaccaaaatttgtgcacactcaagtcctgcagtcacccctgcctaaagatagaatggcttctctgtttttcttctgaaatacaaccagaaacaatgtgtctatttctgaaagaataggattaatgatcatacaaatgggttaatcctgaattctggttgtaaatctggttacagcataactaggattataatgctgcctcattttcacagcactacttgcttatattgacaacaaatcatctcgctaaagagtgaatgtaggccaggcgcggtggctcatgcctgtaatcccagcactttgggaggccgaggcgggtggatcacgaggtcaggagatcgagaccatcctggctaacatggtaaaaccccgtctctactaaaaatagaaaaaaagaaattagcctagcgtggtggctggcgggcgcctgtagtcccagctatttgggaggctaaggcaggagaatggcgtgaacccgggaggcggagcttgcagtgagccgaggtcgtgccactgcactccagcctgggcgacagagcaagactccgtctcaaaaaaaaaaaaaaaaaaaaaaaaagagtgaatgtaatagtcttgcagaaaatgaatgaatacctttgttcaataaaggaaatatgcactgctcacttttttgaaggaaatgccaaagttacgttttacaacaaggctagagtttgtaaattctgggttcatttgtgatgacataagtcagcaaactgcgggaatactgtctcttctatgtattttgtgaatagtaagcataattttagttttgtattatcaatgaaaatttcacttgaaattaaagctgccttttgttatatttttaacctataggataagattccagtattgtatatgagttttaacaaattaaaaaatcaaatcatgtacatttgaaaatatttgcacacatttaaaaataaatgtaaagttgtcttttaaactactcggatgtgtcctttctgaacaa

人野生型SLC26A4基因组的非限制性实例是SEQ ID NO:7。SEQ ID NO:7中的外显子是：核苷酸位置1-221(外显子1)、核苷酸位置1005-1171(外显子2)、核苷酸位置2262-2801(外显子3)、核苷酸位置11504-11614(外显子4)、核苷酸位置13530-13714(外显子5)、核苷酸位置14311-14475(外显子6)、核苷酸位置22568-22720(外显子7)、核苷酸位置22821-22903(外显子8)、核苷酸位置28419-28566(外显子9)、核苷酸位置29490-29603(外显子10)、核苷酸位置33769-33846(外显子11)、核苷酸位置33987-34082(外显子12)、核苷酸位置35299-35405(外显子13)、核苷酸位置37408-37477(外显子14)、核苷酸位置39449-39541(外显子15)、核苷酸位置40467-40562(外显子16)、核苷酸位置41193-41423(外显子17)、核苷酸位置43697-43751(外显子18)、核苷酸位置49420-49565(外显子19)、核苷酸位置51905-51988(外显子20)和核苷酸位置56348-57175(外显子21)。内含子位于SEQ ID NO:7中的这些外显子中的每一个外显子之间，即，处于核苷酸位置222-1004(内含子1)、核苷酸位置1172-2261(内含子2)、核苷酸位置2802-11503(内含子3)、核苷酸位置11615-13529(内含子4)、核苷酸位置13715-14310(内含子5)、核苷酸位置14476-22567(内含子6)、核苷酸位置22721-22820(内含子7)、核苷酸位置22904-28418(内含子8)、核苷酸位置28567-29489(内含子9)、核苷酸位置29604-33768(内含子10)、核苷酸位置33847-33986(内含子11)、核苷酸位置34083-35298(内含子12)、核苷酸位置35406-37407(内含子13)、核苷酸位置37478-39448(内含子14)、核苷酸位置39542-40466(内含子15)、核苷酸位置40563-41192(内含子16)、核苷酸位置41424-43696(内含子17)、核苷酸位置43752-49419(内含子18)、核苷酸位置49566-51904(内含子19)和核苷酸位置51989-56347(内含子20)。

人野生型SLC26A4基因序列(SEQ ID NO:7)(NCBI参考序列：NG_008489.1)

1 ctcagccttc ccggttcggg aaaggggaag aatgcaggag gggtaggatt tctttcctga

61 taggatcggt tgggaaagac cgcagcctgt gtgtgtcttt cccttcgacc aaggtgtctg

121 ttgctccgta aataaaacgt cccactgcct tctgagagcg ctataaaggc agcggaaggg

181 tagtccgcgg ggcattccgg gcggggcgcg agcagagaca ggtgagttcg ccctgaagat

241 gcccacaccg cccggcccgg gctccactcc cggggaggcc tcgagggttg cggatgggac

301 tcttaagtgg tcacggatca ggtgggcagg gggcagtaca gctttctttc tgagacgccg

361 agagcgaaca ggctgctcgg aaaacaggac gaggggagag acttgctcaa taagctgaaa

421 gttctgcccc cgagagggct gcgacagctg ctggaatgtg cctgcagcgt ccgcctcttg

481 gggacccgcg gagcgcgccc tgacggttcc acgcctggcc cgggggtctg cacctctcct

541 ccagtgcgca cctggagctg cgtcccgggt caggtgcggg gagggaggga atctcagtgt

601 ccccttccag ccttgcaagc gcctttggcc cctgccccag cccctcggtt tgggggagat

661 ttcagaacgc ggacagcgcc ctggctgcgg gccatagggg actgggtgga actcgggaag

721 cccccagagc aggggcttac tcgcttcaag tttggggaac cccgggcagc gggtgcaggc

781 cacgagaccc gaaggttctc aggtgccccc ctgcaggctg gccgtgcgcg ccgtggggcg

841 cttgtcgcga gcgccgaggg ctgcaggacg cggaccagac tcgcggtgca ggggggcctg

901 gctgcagcta acaggtgatc ccgttctttc tgttcctcgc tcttcccctc cgatcgtcct

961 cgcttaccgc gtgtcctccc tcctcgctgt cctctggctc gcaggtcatg gcagcgccag

1021 gcggcaggtc ggagccgccg cagctccccg agtacagctg cagctacatggtgtcgcggc

1081 cggtctacag cgagctcgct ttccagcaac agcacgagcg gcgcctgcaggagcgcaaga

1141 cgctgcggga gagcctggcc aagtgctgca ggtagcggcc gcgcgggcctgcgtagagag

1201 aagcggagcg gggcgtccac gccttgggga gggaagggcg tccccagcgggcgagagtgg

1261 ggtgcgggcg gcggagcccc tgggcgccag ctgcttctcc cagaggcccgactttcggtc

1321 tccggtcctc cacgccgccc ttctggtggg agggtggctc catcagtctcgggcccgaaa

1381 tgaacttacc tgggaaactc gcctttgggg agagtgggtt ctaggagccccgtctctctt

1441 tttcctctct gaaggaaact tggagtgcct cttggggtac agtgggtccctgttgccttc

1501 ttgggagctt gtttaaatga aatgaatagg gaaacccagc tcttgaccaggaggagtcct

1561 tgaaacactc aagctaagta ggcgggctac cattcagtta gagaccaggatgcaagctag

1621 aacccagggg agcgcggggt gtgccaagta cttcatcagc aggctgtgggacccctgggg

1681 aaagccaccc tcagtctcta aacccaaaca tgccgtaact agatgtcacaaacataaaga

1741 aattagagtt tctaaaacct ttcattatag aacatttcaa atatatgcataagtagacgt

1801 agtagtataa tgaactcccc acccccaccg tttttaaccc atcactcggcctcaactgtg

1861 atcaaatcca agttactctt gtttcttgta tctacaccta cttgctccctccagtattat

1921 ttttaagcaa atctcatata gcatactgtc tttatgtatt ttactgcatatctttaaaga

1981年ctcttaaaaa atataaccac atttcatgat cacaccttaa tatctaaaaataacctccta

2041 atatcaaaaa ttgagtcatt attaaaatgt ccaatcgtcc cataaatgccttaattaaaa

2101 aacaatttat tcaaatcagg agttatacca cctacttttg atatttttctttcatctgta

2161 ggtcactgaa tttaaaaact accaagtagc aaggtataag gtatacattcctcatgctaa

2221 gatttttgta aaaactagct ccaggcttgt attgccaaaa tatactcagtgtgtttatct

2281 tctttaaaga aaataataat aataaggcgc ctggattagg agtctgaaaagtaatctcca

2341 tttagagact ccacatccat cagtctctgg ctggaccaga aaataggtttttgtgtagga

2401 atattttttc agaggattaa aaatgtgagc gaggggtggg acacttaatcctgtgttctc

2461 tagaagagtg catttaaaag gatagataca gttcttggca aaagcatggtaagcacttca

2521 gggttattat tttccaggaa atacttatcc tttttccaaa tagttataaacatcagcaga

2581 atccagttca taactttgtg atttgcaaat tggttgtgac tgagattggattgaaaaccc

2641 agttttcttg ctttttgaca gttgttcaag aaagagagcc tttggtgtgctaaagactct

2701 tgtgcccatc ttggagtggc tccccaaata ccgagtcaag gaatggctgcttagtgacgt

2761 catttcggga gttagtactg ggctagtggc cacgctgcaa ggtaagatgttggcagattg

2821 agagttctgg tctccagcag gagtttaaca cttctcccca gctaccataggtctgtgaca

2881 gatggttgct tacccttcaa ggcctgtatc tttcctgtag agccccttagtggagagagt

2941 cacctctctt ctccccttcc ttagagttct cttcctggga aactgctgccccactaggtg

3001 cagaggtcca atttagaggc atatactagg cagtggcttc tcaatttttttaaattttat

3061 tttatttgag acgggggctc gctctgtcac ctaggctgga gtgcagtggcgcaatcctgg

3121 ctcactgcaa gctccgtctc ccgggttcac gccattctcc cgcctcagcctccccagtag

3181 ctgggactac aggcgcccgc cactacgccc ggctaatttt ttgtatttttagtagagacg

3241 gggtttcacc gggttagcca ggatggtatc gacctcctga cctcgtgatccgcctgcctt

3301 ggcctcccaa aatgctggga ttacaggcgt gagccactgc acccagccagcttctctatt

3361 ttcattgacc acaattcaat aagaaatgtg taaagagttt caagtcaagatttaaaaaaa

3421 aaaaagaaat gtgttacatc ctgatatata catatatatc taaagttcctgtgaaatatt

3481 tattataaca atgtgctaat ctttcacttt gttctattat gcttaggttttttaaatgat

3541 gattgcagca cattaaatta ttttatatcc acacgtggat cttttttgttggtttgtttt

3601 gctttgcttt ttagagatac agtcttgctc tgtcacccag gctggtgtgcagtggcacga

3661 tcttggctca atgcaacctc tctgcctctc gggttcaagt gattcttgtgcctcagcctt

3721 ctgagtagct ggggctacag gcatgtgcca ccatgtccag ctaattactgtatttttagt

3781 agagatgggg tttcgccatg ttggccaggg tggtctggaa ctcctaacctcaagtgatcc

3841 gccctccttg gtatcccaaa gtactgtgat tacaggcatg agccaccatgcccagcctcc

3901 cacacgtgga tcttgaggtg tagtttgaaa ctggcttaag gaaaagtgaagggagcttcc

3961 tagcctggac tccacatgaa tgttttgcct gcccctcatc cctttttaaaaaaattcatc

4021 ctcttatttt aatgtgtggg aaaatgtgcc aacataggtg gttatttgttcttttataaa

4081 ctgagttcat accataatat tcccataagc atcttagaaa tctgttgtatagttggtgcc

4141 tagcagcatg gcattctcct ctgtccccta tccccaccat ctcgtttctgccccaccccc

4201 aacaccctga ccaatttccc aaagaccctg aatcatgaaa acagaaatatcgttatttat

4261 tataatttgt gaaacaccta atatgttcca ggcactaggt atgctgacacgaataagatg

4321 catcctctgc ttccaaggaa ctcatagtcc aatggagaaa gagaaaacaattcaatgtga

4381 taagggctgt ggcaggggag tgcaaattac ttgctaaggg agtgcaaatgaggttcactc

4441 aaagcggtct taggggatct tgaatagctt cctggaagtt gaatgtcaaagctgagtttc

4501 cctgatggct aagtctgagt ttgccaagtg atgggaagta gggtggggtggggatggctt

4561 gaaaatagac tatttcagaa gctagtaatg aatgttgagc aatattgtgagctaaaattt

4621 ggctatggag ctttcaagat tgctcagatc aggccaggta gatgcccgaagagaaggagg

4681 atggcctatg aacccagggt ggagcctcag cctgatcaag catgttcttaatcacaaagg

4741 tggacgggag agagactagg atgggctgtg tggttcctaa gttaaacaatgccaagtatt

4801 ctacactgtg ctctaagggc tgtgacatgg tgacaccctg tgactcctgggggacaggaa

4861 ccatgcctca ttcatgtttg ttcagcaggt gcctagcaca gagacaggcacataatagat

4921 ggtatattta gtgaaaaaga ttgaattgca ttcctgataa tgaatcttctttatatataa

4981 aaaatggtgg ttcatgctcc atgtctcccc agttttcata gacaagtatcttataagaat

5041 tcattttgtt tataagcatg agacactatg ctaagtaaga atgttgccagctatctcatt

5101 taatcctcat aacaatcctg ctaggtaggt ctattattat ttcattttcagtaggtgaaa

5161 aaatctatta aatcttgccc agggtcacgt ggctggtaag tggtacagctgggattttaa

5221 tccggtgtct attgtgtagt tccttacttt atgggtaaga tgcttttctagaaacattat

5281 ctctataaag ttttctgtgt aaggtgaatt tctgggaggt taatctggctcagttacaca

5341 tccatttatc attcattcac ttaataaata tttataaact aattctgtagaccaggtatc

5401 cagccatgtg cactcagtgg ttcattaaca ggcacaggtg ctgacttcatggagctttgt

5461 aaaattattt tgaggggtag ggatgggaat taaataagta gataaatagaaaaataatta

5521 tagattgcaa tatctattgt ggtggattaa atatactgca atagggattaatttgaaagg

5581 tggatcttta tttttatatt tttttgagac agggtcttgc tctgttgcgcaggctggagt

5641 gcagtggtga gatcacagct caccacagcc ttggcctcct gggcccaggtgatcctccca

5701 tctcagcctc gccagtagct ggaactacag gcatgtgcca ccatgcttggctaatttttg

5761 tattttttgt agagacaagg tttcaccatg ttgcccaggc tggtctggaactcctaggct

5821 caagttatct gcctgcctcg gcctcccaaa gtgctgggat tagaggtgtgagccattgtg

5881 cccagccagg aagggaggtc tattttagat ataatggtca aggaagaacttactgagaag

5941 gtgaaattta gtaaaagaca agagaatgag aaggagacag ccatgtgataagcagaaaaa

6001 aagagtgtac caggtaaagg tgcaaaggcc ctgaggccag aaaacttagcattttccagg

6061 gaggaagagg aagaattgta gtgtggatga gtgcagtggg ggagggtgagtaaaccatga

6121 aataaactga ggcaggactg ggattaggat gaggtaaggg aggcactcactctcaggatg

6181 cctctttaaa tattgtaccc taggaaactc atttgcctca ccctattcctggccctgtgg

6241 ggatattgct gtgaattaaa gggagaatgg gtgtgtcagc ttgaaccagatgatgcaggc

6301 tatgaagaga gctgcaagat aggaatatat tgtgcagcaa gaatcactgacacataatga

6361 tgagtgtgga tgaaaatcac tgatgcctcc aaggttgttg gcttgagcaaccggatagat

6421 cattacatca tttatctaaa tggcaaagac aggctgagga gcaggtttgggataggaaat

6481 caagtttcct tttggatatg ctaagtttga gacacagggt gagacatctaagtggagatg

6541 ccacctagag aagtgggagc tactgcaagt gtgaaggtta gaggagaggtctaggctaga

6601 cataaaaatc aggaaagcat tgctgaagag gtgatattta caagagtgggaatgcctgtg

6661 attacctagg aagaaagggc aggtgtagaa gaaaagagag ccagagtacttagaagttag

6721 gaaggcaagg agaggggcag ccaagaacct gagaaagcct ggcgcaggaagttgaagaca

6781 aagaacaacc aaaggaatgt gggatcagaa gccaagagag aaggtttaaaaaaaaaaaaa

6841 aaaaaaaaaa agcatagagg ggctgagagt gttgaatttg cctgaggggtggggtatgat

6901 gaaggattac agactgcttt taagaagttt tgccatgaat cagagggagataagagatga

6961 agacagagtg aagggagaat ttgtttttct taatatggga gatactagaacgtatttgtg

7021 aaccgatagg aatgacctag tagaaagaaa gagatctgtg gtgcaagaagtacaagagaa

7081 ataactagaa gcaaagtagt aaaaaggggc aaacgtggag gggtttgagaatggaactag

7141 gagaactact ccttaaaggc aggagggata tttcttccat tttcaaaggaagatagccca

7201 aatggtgcag atgcagacgg gtttgaaatt ttgatgaaaa gtaacttgggagcatctcat

7261 gcattctgtg ttttcgatta aatgcagaat atgtccctta actttgagtctggtggagaa

7321 gggtttgggc agattgaggt aagtagggga ggtttgaata gttgtctcaaggagaggaaa

7381 ggcacacccc ctgaggaaat gtaactgggt ccccaggcag tgttgagtgcccatctagca

7441 cttgtggtca cacattttac atgaaattgg ttagcccaga tgtagatgccttcagtccag

7501 tttatctagc tgctcaaagg ctctcatgga taaggtagat gtttgaggtcagccaaattg

7561 gggttttgcc agacaagaaa aggaaggaaa gagagagtga aaaaagggagttaagaatat

7621 ttgcaaaatt ccatggaatc tgtgtgggca agggtggaag tgaagacaggaaggtgtgga

7681 ggatagagag aaagtggatc ggttaattaa ttagaagcct cgtgagcacaaataaatgtt

7741 gcaataagga ttctgcagta gatgagctgg aaggtttgga ggctgtagctggagagaggc

7801 tcaaaattca gattttggag gtggtggtgt ggtttccagt gatgacaatgtccatgccac

7861 aaccactggc tgagcagctg agtagtagaa caactccgag aagaccagctcaggttactg

7921 ggaagccagg aagttgctaa ggatgatggg atctttgtga tttttgttattaaaacaaat

7981 tcccatcaga cagcaaaaga tcgatgcaac ccttgtagtg ctatttttattcacaacttt

8041 aaggagtctg ctgtctgctt tctccttttg acttttatgt atttgtttgtttaaacaaca

8101 gaaatttatt tctgcaacat gaaggtgcct gtagattcag tttctggtgacagcccgtca

8161 ccttgctgcg tcctcacatg gtggaaggct ttacctttag aagaaatttaaatttaatat

8221 aaatttcaac tgtttattag cacctgcttt gccagtattt gtcaccatgctataaatcat

8281 gactaccaac agagaaattc tatcatttaa atcaatggct cagatttcttctaatttttt

8341 ttcttttttg agactctttc tcacacaggc tggagtgtag tggtatgaccttggctcact

8401 gcaaccactg cctcctgggt tcaaactatc cttgtgcctc agcctcctcagtagctgaaa

8461 ttacaggcat gtaccaacac ccccagctaa tttgtgtatt tttagtagagacgagatttc

8521 accatgttgg ccgggctggt cttgaactcc tggcctcagt gatcttcccacctcagcctc

8581 ccgaaatgct aggattacaa tcatgagcca tcacacctag ccccagatttctttacaaat

8641 tgtgtaattt taaaactgtt gtaccaagtt tctttataat aaagatgattccagtatatt

8701 tgagtagtag tggtccctaa atgggacact ctgtatgaaa actgaaaagttccccttttc

8761 caggcatatt aagaactgca gagcccagtt tggggaaatg gaagtttgagaaggacttga

8821 aaaatgtcca tatgaaatag acaagttgtg ctttcatccc ctgctccttcttttcttatc

8881 ttccttctgt ggagtcacct tcctatttta ttccatgctg ttgggactactgactattgc

8941 aattcctgtt tgtaatttac atattaaaac aattgtacta atagatatatttttctagaa

9001 tacaaactcc actagggcag agactttgtt ttaacagtgc ctgacacatggtaggtgcat

9061 aatcaactgt tgttgaatga atgaatgctt attgtagaaa actagaaaatacatataagg

9121 aacatgaaaa aatacctcca ctacaaacta gaagtctcct ctgatcctaccatacagata

9181 acccattgat atttcagtaa atatcttact aggcacataa atacttatctatataaaagt

9241 ataatgaaat gtctggaaat aataagcacc aaattcagga taattgttgccttctgaggg

9301 tagagggagg aaagaggatg tgattgagga agagtatact gagagtttccgctgcattgg

9361 cagtaattta tttcttaagc tagatgatgg atacatgaaa gtttattatattattcattg

9421 tgtattgtgt ttcttgtata tgtaaattac ttcatatttt attcaaaatacctccagatt

9481 tttttttttt tttgagatgg agtcttgctc tgttgcccag gctggaatgcagtggcgcaa

9541 tctcggctca ctgaaacctc cgcctcctgg gttcaagcag ttctctgcctcagcctcctg

9601 agtagctggg attacaggtg cctaccccca tgcctggcta atttttgtatttttagtaga

9661 gacggggttt caccatcttg gccagggtgg tcttgagctc ctgacctcctgatccaccca

9721 cttcggcctc ccaaagtgct gggattacag gtgtgactca ccgcgcccggtccctccggc

9781 tttttttaat gcgtacactc ccacaggctg gagtgggagt gtattttttacaaaagagga

9841 agcatacata cctatcagtt ttgaatcttg attttactca cttttttccctcttacttca

9901 catctctcca cgttactgaa tgtacttctg agcatcacat caatttcatttcatagaatt

9961 acgaagtatg aagcataact tagttaacca cttccctgct tggggacattcatctgataa

10021 gtaatattga gtgtgtgggg gccagcatat tcaggctgtt gccatttttaataaactact

10081 ataaatgtaa ttccttatta atgactcaag agtgaaaagg cttgattttctctcattgtg

10141 agtgagtgaa gggtgaggag gtaaaacgga gtaagatatg ctggctacctaagtatttaa

10201 ccaaggaaaa gaatgtcatt atcctcttct aaccctcatg taaactagaatgttgatttc

10261 tctatagcca ggcattaatg ggtctggggg ctgctgccat tgcctagtggaggagttggt

10321 caacttcatc agggtagagt tgtcttgtct gctgctgagt ataattatcatattttttct

10381 ttgggtctaa cttttcttcc ccaccaaaaa aggagaaagg gcagtgtaacaatgactgtg

10441 tccctcagaa cgcagagaaa tattgagctc agacacaact gcctctgtgcaaaactggtc

10501 tgagcctttg gagtgaattg accaaaactt ttttttttct tttttagacataaggtcttg

10561 ctctgttgcc caggctggag tgcagtggca cgatcatagc ttgctgtaacctcaaactcc

10621 tgggctcaaa caatcctcct gcctcagcct ccttaataac taggactacaggcgtgaacc

10681 aatatgctgg gctcattcat tttattgtag agatggagtc ttgctatgttttccaggctg

10741 gtctcaaact cctgggctca actgatactc ctgcctatgg cttcccaaagcactgggatt

10801 ataggtgtag gacaccaggc ctgaccaagt ttttaatcaa catttgacttgattgttttt

10861 tcccactgat ctgattggtg gaagactgaa ttactgatca actgagtccattcatttgag

10921 caggtgatgt ttgtagatgc aatcattgtt ccaggtgatt tggatcctgttctgcatcct

10981 agcatagcca gtctgtatgc aagataagga gaccaactca ggacaggctgatctgttgaa

11041 actgtaaatt gagagtatct gtgtaaaggc ccttctttct gcagtagaaagacagatgct

11101 cctctacttc tcatgagtta catcctaata acccattgca agttgaacatattttaagtc

11161 aaaaatgcac ttaatacacc taacctatgg aacatcatcg cttaggctatcctacctgaa

11221 atgtgctcag aacacttaca ataacctaca gttgggcaaa ataatctaacgcaagcctat

11281 tttataataa agtattgaat atctcatgta gtttactgaa taatgtactgaaagtgaaaa

11341 acagaatggt tgtatggtta cttaaagtat ggtttctact gaatgcatattgcttttgca

11401 tcatcataaa ggcaaagtca taagtggaac cattgtaagt tgaggactttctgcatactg

11461 taactttggt ttgtgaatgt aatcactttg catgtgcttt cagggatggcatatgcccta

11521 ctagctgcag ttcctgtcgg atatggtctc tactctgctt ttttccctatcctgacatac

11581 tttatctttg gaacatcaag acatatctca gttggtaatt ataagtatattttacaatta

11641 tatttgctca tgtttaaagt gttttggcta tattaagtgc attatacctctattaggttg

11701 gtgcaaaagt aattgcggtt ttcacaatta tacttttaat tgtgaaaaccgcaattactt

11761 ttgcaccaac ctaatatatc tgtgttaatg ttgtcaggga aatgggatttcagtgttttg

11821 cctgcttttt ctattcactg atgttaggta acttttttaa tgaagtggaaaaataaaaaa

11881 actgaaaatg acagcctact ttaacatttt agcatgtttt gctttttaaaaacgtgatca

11941 atttgactcc atttttggag tcataatgac agggaaaaaa tgacacaaggtctttgaacc

12001 taccatttta ctggattaac ttagaaatta ctaagtatgt tcatcaaatacatgttcatg

12061 atttaattaa agagcatact tattttaaat cactaatatt agaagactggcaaaatctta

12121 ccaaaacaat ttagaagcta agcttggctt tctttcttgg tatggcttataataagtttt

12181 cctgctattc ctaaaatttg aattctcgtt tgttagaatg tcctagtaaatgagtgtttt

12241 aatgctattt tgtgactttg acatttatac tagagaaaat tttgctcctacatccatctg

12301 ctggctagac atgtctacct cgatgatcct cttgaaataa atgcaaccatctactttatc

12361 cccaacccat gtttttgtcc ttagttgtat ttccttagaa ggagatcagaaagaggtttt

12421 gattgaaaga acttccacac cttggagaat caatcagtgt tgagtgcttgactagatgag

12481 gaacatggaa gctggttttt ctctttggta ttctatacat tgagatattccaggtgactg

12541 gggttgggtt ttgagacctc aaaaccataa agccttccat gatgagagggtagaatcatc

12601 atcatcgtca tggataaaaa taacagtagt gaacggagca attgctgaaaaaaaaatatt

12661 ttttaaaata taaaatctta cagattgaca tttgatatga aaaaatgttttgtcttacaa

12721 aaagagaaag aaacttcata ctccctttgc tgttttttta atcctaacttcgaccctgtg

12781 atattgatca aggtactcag atccacagag atcaggacat tggacactctaggaaattaa

12841 tgagattata tgaaataaaa gttgagcgga acaagtaaac actcaatgtatgtgctacct

12901 ttgccagaaa acctttcctg acaactctca tccctgtccc caccacccatacacatgagg

12961 atcacacaca gacaggttag acgacctttt gatatactca cgaagcatcctgaatgttgt

13021 attctaataa ctacctacgt gtctctctcg cctatttcta ggtcatgaatgcctcgagat

13081 atctgcgttt ttagcttctt tttgttgttg ttgagacaga atctggctctgtcacctagg

13141 ctggagtgcg gtggcgtgat ctcagctcac tgcagcctcc acctccccagctcaagcaat

13201 ccccccacct cagcctcccg agtagctggg accataggca cgcaccaccacacccagcta

13261 atttttgtct tattttggta gagatggggt tttactatgt tgcttaggctggtctggaac

13321 tcctgggctc aagcgatctt cccacctcag tctcccaaag tgctgcggttacagatgtga

13381 gccactgggt ccggctcagc ttctttcgtg aacaaacaat attttcctagtcacagctaa

13441 atcttttata cattttttaa accctatgca gacacattga acatttgtgattaataactg

13501 attaattgtt agagactttt tttccccagg accttttcca gtggtgagtttaatggtggg

13561 atctgttgtt ctgagcatgg cccccgacga acactttctc gtatccagcagcaatggaac

13621 tgtattaaat actactatga tagacactgc agctagagat acagctagagtcctgattgc

13681 cagtgccctg actctgctgg ttggaattat acaggtaatg aacttacaagtaaaatatag

13741 atggatgtaa tttttatttg aaattaactt taaagcatat agacttaaagattctactaa

13801 aaacaaaaca aagtaatttc ctggaaccca aaattatttt ctaaattacgttgttttagg

13861 tcaggtgcta aaatagtaag caagacccca cttattaagg ctcacttatcatcaaagtca

13921 gagacagaaa aaagcacaga agaacatgtg tgattcaatt gaggatgagagaagggaaat

13981 atacgggaat ccataaagga gaaaaagtgt tctggtgagc ggagacacaggaccgaaagc

14041 cacataaata agctctgggt ttttgctttt ctaagtacat gtatagaaatacttcaaggt

14101 ttttattaca cttagttttc aaattttaga gtggtggagg aaggggagtgatagggtatt

14161 aagaaattca tatttttttc taccagtatt tttgtgctat aggcaggctactagtgtttt

14221 cattggtatt aagcttgatg taatatttcc agagagtagg tttctatctcaggcaaacat

14281 ttaatttttc tttccttttc cttatcgtag ttgatatttg gtggcttgcagattggattc

14341 atagtgaggt acttggcaga tcctttggtt ggtggcttca caacagctgctgccttccaa

14401 gtgctggtct cacagctaaa gattgtcctc aatgtttcaa ccaaaaactacaatggagtt

14461 ctctctatta tctatgtaag tgttgcttct tgctccaggg atgggtcactgttcattcca

14521 gaaacaattg tattcattct ctgagtctgg gccaggcgtg gtggctcacacctgtaatcc

14581 cagcactttg gaaggccgag gtgggcagat tgcttgagcc caggagtttgagacgtgaga

14641 cctcatctct taaaaaaaaa aaaaaaaaaa aagaaagaaa gaaaagaaaagaaaaagaaa

14701 gaaaaaatcc aaaaatccga aaatttgctg ggtgtggtgg tgcacacttgtagtctcagc

14761 tacttgggag gctgaggtgg gaagatctcc tgagccctgg aggttgaggctgcagtgagc

14821 tgtgatcgcc ccactgcact ccaccctggg tgacagagca agaacctgtttcaagcaaaa

14881 acaaaatcaa aacaaaacaa aacttgagtc tgggagcacc cacatttctttctttctttc

14941 tttttttttt tttttttgag acagagtctt actctgtcac ccaggctggagtgcagtggc

15001 atgatattgg ctcaccacaa cctccacctc ccgggttcaa gcgattctcctgcctcagcc

15061 tcctgagtag ctgggattac aggcgcccgc caccacaccc agctaatttttgtatattta

15121 gtagagacag ggtttcacca tttgggccag gctggtcttg aactcctgaccttgtgatcc

15181 acccacatcg gcctcccaaa gtgctgggat tacaggcgtg agccaccgcgcccggcctgg

15241 gagcacccac atttctctat gcatactttg ggagccattg aaaacatttggttgcttctg

15301 tcagaaatac tattgtactt aaaaacatta atgaaaacaa agtggtctaatgaagtaaag

15361 gctgctctgg aatgtaacag acttgatttc tagcctcagc tttgtctctaacaggtaagt

15421 gaccctggat acatcatgta gggtgctaat tgaaagctca gttttagaactggatggacc

15481 ttgattcata ttctggctct actgtctact agccatgtga gccaatcaccatgcctcagt

15541 ttccttctct gcaaaattgg gttagtaata gtatatgcct cattggattgttaaataaga

15601 atagataagc acttggccca ggggctggta cataacaagt actctaaataaaggagttat

15661 tttgaaatga ttatttcaag ccatcttttc ttttttattg gtgaaatgaaatgattggag

15721 atgtatctct aaaagctttt tctaaccata agagtccgta aaatgcataatgtaaatgtc

15781 tcaacaatta taaatgaaaa ggaacattag attcagagat gattcaccatgcaaaagaaa

15841 tgcaaaagca ggatgtagat cacactaatt agatttgaaa aaggttttggatctaaaaat

15901 gtgttctaca taaagcatgt tattgatgct tgaaaaatgg tgataatagtaacatgatgt

15961 catcctagct tggggggaat gataccatac aaaaataacg tgtcaacattaagaatggag

16021 tttgagtctt taaagaccca cctattagct tctaaaacaa tgtaaggccatgtacacata

16081 tctaagaatt ggtgagtatg tcaataattg ctcaatttta taacggtgccataatcccat

16141 actattacac tccatccatt caacaaatat taccaagtgc ttactacaggccaggtacta

16201 tgctaagcag tgagaataga cagaggaggc agaataacat agtgaataagatcatgaggc

16261 caggtgtggt ggctcatgcc tgtaatccca gcagtttggg agactgacacaggtggatca

16321 cttgatccca tgagttcaag atcagcttgg gcaacatgac aaaaccttgtccctactaat

16381 aatacaaaaa taattagaca tgcattgtgg cacgcacctg tagtcccagctacttgggag

16441 gctgaggtga gaggatcacc tgagctcagg aagttgaggc tgcagtgagccgagatcatg

16501 ccactgcctt ccagcctggg tgatgggagt gagaccctgt ctcaaacaacaataacagca

16561 acaacaaaca aaaaaccaaa aacaaacaaa aaagatcatg gactttgaacttcaacagac

16621 ttgagttggc atcttggttc tccacccact acccatgatg tttatactcaacttccctaa

16681 gcctcagtgt cctcaattgt aaaatgggag tagtaatagt agctacctcttagagcagtg

16741 aggattgaaa aagaaaatac gtgtaaggca cttagcacaa tatctgtcacatagtaagaa

16801 ttgagtttat tattattatt atcacagatg aatagacctc atgaagctcgccgttcattt

16861 cctcgggacc cagcctatta ggaaacatta gcaaaagttt ttgattcagcattatatggg

16921 tcattcttga tatgtttttt cctgtcaaat cctcagtttt ctattaaaaaagaatttttt

16981 tttttttttg agacagggtc ttgccccatt gcctgggctg gagtacagtagcacagtcat

17041 agctcactgc gacctccatc tccctgtgtc aagcgattct tccccctcagcctcatgagt

17101 agctggaact acaggtgtgc accaccacac ctggctaatt ttctttttctttgttgaatt

17161 ttagtagagg caatgtcttg ctatgttgcc caggttagtc tcgaactcctgagttcaagt

17221 gatcctctca ctttggcctc ccaaagttct gggattaaag gagtgagccaccatgtccag

17281 cccatatttt aaaattaaaa ttaaaatttt aagattttat tttggtagagacaggggttt

17341 tgcaatgtcg cccaggctgg tcttgaaccc ctggcctcaa gcagtcatcttactgcatgc

17401 ctcctaatgt gttgggatta taggtgtggg ccactgcacc tggccaatccttagttcttt

17461 ttgagacctc tgactgcctt attttgacag gctctgtaac ttttgcagctcctggcacat

17521 cttgctttta cttactttta cattttctcc atcaaatgtt cactcatttattccttcatt

17581 ctcattcatt cagtttatct actcaataaa cacatattga atacttaccatgtgccaggc

17641 actgttcact ccctatacaa acccagtgac tcattaacct accaagacatctcttactga

17701 gtattctcac ctcactgggc aaacattgct aggccttcat ctacacagatcgcaggaggt

17761 ccaaactaat tgttgacctg ggtccatggc catttcagga cccctgcagaacaggagaaa

17821 tagttcttct ggtctcatag gattatgttt aagaagaaac tttctgcaaatgatttcact

17881 ttgacaggga caaaagtgag caggaaacac tagaccaagg tcaaaaatagtttttaaacc

17941 aagtgcagtc attatgtaac ttacttcctg ttgaatattt ttcttgaaatctcagtttag

18001 catacagcat agaattttgc aagaaactcc tcacaggcca cccaagttggaaaaggtatt

18061 tcagtcatcc ctatatggtg gtgaatataa gtttgctctt ctgaaaaaaaaaaaaaatca

18121 gcaggtctga aaacgattgc atagggttaa atgagccgct tagtctctgaacagagaatt

18181 ttgcttatga cattaccatt gcaattatac atgaaagaat ccttcaataaatgcagagta

18241 gtagaggatt ctcccagaaa agactgtaag attgttgtaa aatactttacctggagtgtt

18301 aacttatctt tgttctaagg ttgcactttg gtttgtcctg ccctctcccccaaaaaggtg

18361 ctgacaacta gaagtaacaa atgcaaagaa ataggggaga aaatattagaagaaaaagaa

18421 atcagttaat ttacaaatgt cagagatact ggatgtagga ggcagaagggagaatgacag

18481 ggtattggca gcaatttaga attagtcaat acccttgatg ctaccatgtagctactcagt

18541 tatctaagta aatcccagtc cacttagggg ttgatttccc accactcaatttgaatggtt

18601 tgtctcagta gacaagggtg agagctttga aagccaccac taagcttgattagatttgtt

18661 actttgtacc tatttcagta tgtaaaattt atacattgta ttaaagtaacactttaagga

18721 ttgatctata catgtataca caaaagatat ggaaggaaat gcctgacagcaaaaggtggt

18781 cgtgaagcat ttgtgatatt cgtagagata aaataaacaa aaataaattcagttccaata

18841 gtaaactgat caattttctc atacacatta ttgggcataa ttttttcttacggtttcata

18901 aacacaggta atcctgggca agaacaaaga aattatctaa atgaaattgtcctaaaattt

18961 tccaaacaca gcaggaaata taataaaata ttatctatta ccaaaaagttcattatcata

19021 atttgaatta tttggaatac taagctaaaa tacagaatta tatgtgtatccatactatta

19081 acatacttta tggtatttta acagtaaact aaattagaag tactgttcagtgtttttgta

19141 gagtctaatt tctatgtcgt taaatataat cttatattat tatataatataatcttatat

19201 tattatataa tcttatatta ttatattata taatcttata ttatataatcttatcttata

19261 taatcttata ttatatgctc ttatataata taatcttatt atataatcttatcttatata

19321 atataatctt attatataat ataatcttat tatataatat aatcttatcttattatataa

19381 tataatctta ttatataata taatcttatc ttattatata atataatcttattatataat

19441 atattcttat cttattatat aatcttatct tattatataa tataatcttatcttattata

19501 taatataatc ttatcttatt atataatata atcttatctt attatataatataatcttat

19561 cttattatat aatataatct tataatataa tcttaactta ttatataatataatcttatt

19621 atataatctt atcttattat ataatataat cttatcttat tatataatataatcttatat

19681 tattatataa tcttatctta ttatataatg ttatattatt atataatcttatcttattat

19741 ataatgttat attattatat aatcttatct tattatataa tcttatattattatataagt

19801 ataatctttt attatattat tacataatat ataagtataa tcttatattattatataata

19861 ttattattat acaataataa tgtaaactga ctattgcagt ttacatggtgagttttattt

19921 ctgcacagat taaactttct atcatagagc tcttcttaaa agattctgaatgactactca

19981 atatgtaggc aacttattta catactcaga taccttgcat gatgcaattctgtaatataa

20041 actgattttg gtttttgaac ctcgtgttac atttctaatc caccagacatactttttatt

20101 caaaggtcta attgattctc atggattaaa ctggaatcct gtagtgattatttttgtaag

20161 gtaaaaatgt ttgtgtgatt gggataatga ttccaaatgt tttgtttttcaagttttaat

20221 ttttgcatct tgagttgaaa agtacacctt taatgaatag acaattcatcaaaatgttat

20281 acctagctcc tgaattaatt agggtcattc atcagaaaac tgattatgtaaaggaccaaa

20341 cagcaatgat aaccttcaag cctctgggat aggtagggct gtttgctcctgtgctaaatg

20401 ccctaagttc ttgttatcgt gtctgctggt ggtagttatc ccattttctttttcactctg

20461 ctgtccctgg catcatcttg tttctgtcag tgtaaatgcc tttagcaattttcagtgact

20521 ctgaaaacca gacaaagtga atttgttagt actggatttc aagaaagagcaaaagtaccc

20581 tctgagtgaa agttcaagag tcttcctaca agttaaatgc ctgaactctagtccaagtgt

20641 ttggtgggag gtattttgca tgcataatag cttctccccc atttccttactcttcttgaa

20701 tgtgttccag agagctgagg ttgctggcaa agtgactcct agattacttaaggttcatta

20761 agtacttaaa gttcattaag ctcatacata attgtcacca gattatcattataattattt

20821 taaaagtagt ttatctgtga aaataagtaa aatacatttt ataaatgttataaactataa

20881 gatgctccat tattttatct tcctataaaa tatgtctata aaaaagctcatttaaagaaa

20941 agttaccttc actgtgagat tgtctcaaag aaatgtctca aagataccttcttaaatcct

21001 gccttctaca ggactgaagt taatataaca aagatattag tgttcttccttgggattctt

21061 ccttgctaat ttccttgaaa acacccttga ttcccagaag tctcctatttacaaaacaaa

21121 actagttttt cttgaattga ttcatctgtc tacttaaaga ttttttttggccagttgtgg

21181 tagctcatgc ctgtaacccc aacactttga gaggttgggc aggaggatttcttgaggcca

21241 ggagttcaag accagtctgg gcaacaaagt gagacaccat cccctgcccccacctcctcc

21301 cgccccaatc tctacaaaaa ataaaatagc ctatttattg tactctctacaataaataaa

21361 ataaatatag atgcctgcct gtagctccag ctactctgga gggtgatgtggaaggattgc

21421 ttgagctcag gagttcgagg ccactgtact ccagcctggg caagagagctaaaaaaaaaa

21481 aaaaaaaaaa aaaaaatttt ttttatgtta tcttagttca agtttgagaaataaaattaa

21541 gtaccaaatt tattcccaaa aatgtatgct tgtcaggaga tatacctaatgttaaatgac

21601 gagttaatgg gtgcagtaca ccaacatggc acacgtatac atatgtaacaaacctgcacg

21661 ttgtgcacat gtaccctaaa acttaaagta taatttaaaa acaaaaaacagaaaaaaact

21721 acagattcaa ttcagcttta ggaattaaaa aaaagatttg atgtaattatatcattataa

21781 aatcaaattt tttaaataaa acatgaaatt gttttaattt aaaaaaaagtatgcttggcc

21841 tatatgtcaa ttcaatagct tttctttgcc agaaagaatg aagtcagtctacctgtatcc

21901 acatatgaag tattttagga ttttttgtaa ttttttgtta ttatctatatcattcaggtt

21961 taggaaagaa ctttacctaa aatactggct aattgtgccc caaaaaaaagaaagctagaa

22021 agaaagaaca cacacacaca cacatacaca catatacaca cacaaaaaaaacaaccaact

22081 gatcaactgg gagtttcagg tttatcagcc tttagtctca atgctgtatcactgtagtaa

22141 aaatcaggct acttgatagc acctagaaac ccattttaaa atataaacttgtaaagcatt

22201 tctgtaagta aaagttagta tgtttataat gacatttttt cttttaagacatctttatta

22261 ttatcataaa aaatacagag aagcaaaaat aagaatgtag aaatcacccagtttttcctt

22321 tccaagtaaa caatcataaa aaacttggtg tatatatata ttgcagcaattgtatgtatg

22381 taatggtctc tgtatcaacc aacacatttt tatcatttta ctgaaacttttgagtgttgt

22441 ttgatgctga tatcatggtt tttcatgtgg gaagattcat atgagaattgattgtgtgtg

22501 tgtgcgtgtg tgtgtgctcg tgtgcgtgta gcagcaggaa gtatataaaattattttctt

22561 tttatagacg ctggttgaga tttttcaaaa tattggtgat accaatcttgctgatttcac

22621 tgctggattg ctcaccattg tcgtctgtat ggcagttaag gaattaaatgatcggtttag

22681 acacaaaatc ccagtcccta ttcctataga agtaattgtg gtaagtagaatatgtagtta

22741 gaaagttcag cattatttgg ttgacaaaca aggaattatt aaaaccaatggagtttttaa

22801 catcttttgt tttatttcag acgataattg ctactgccat ttcatatggagccaacctgg

22861 aaaaaaatta caatgctggc attgttaaat ccatcccaag ggggtgagtgtggtgttcct

22921 cttagtacta atacattaag tcagtaagtc agtctttttt atttaaataaaaccttttat

22981 tacaagcttc atttcactga tactccttca atagtcctat ttgtgtgtgatctggaagaa

23041 acaaccataa gacaaacagt atgtgtgtag ataaacgtca agccatttgtttaaaagcag

23101 cccgtatatg ctcttttttc ttcattttct taaaacatgg cagaacatgtacggttaaca

23161 ccagagtcct gatttaaact tatacataac attataatat aatataaatagaatcatttc

23221 tcagtaacat ctattgcact gtgaacaatc tgcttaagga atcagggacgtctggcctaa

23281 attctctatc atttagttta atcaattttg gataataatt atatcctcgtacccataagt

23341 aaaatgcatt atcttcaagg gaagttttag aaacatttgg tagtttggtgaattagaaga

23401 gtaaaagatc aaggtccttc attcatctct gtcaccttcc agttttgtgacctgaggaga

23461 ttctcctata taagacaagg ataatgaaaa cagccgaagc ctcaactcaagcttattatg

23521 aaacaccagt gagatctctc atgaaatgaa gagtagtcaa gacaccctacaccataattt

23581 tctcatatgg ggttacaaag gaggcctaga cgtttattat atttgtaacatacactcata

23641 acatttaaga ctagacttgc tgttaatcaa gaagtactag ttttccctaagactggaaga

23701 gtttggtacc ggtgtttcta ccaggaaagg gagtggaggg gagggaagggcacggagcca

23761 ctgtttggta ccagtgtttg ttttccatgc tcttaataga aacttcctcaggcaagctta

23821 ttcccagagc ttattctaca gggaactgct gtattcccat ttgatgaatcttataatttc

23881 ctctaatatc tgttccaaac tatttgaaaa agcacagctg gctacatgggacttaatttg

23941 catgctatcc attacagtgt ttctcaaact tacccttttg taagaatcacatgggatcct

24001 ttttcacaca gattcctggt tcccacccca aacctattga atcaggctttccagaggtgg

24061 ggctcaggaa ttaatatttt tcaaaagtgc ctcaagtgat tcttgccctcaaggaaactg

24121 gagaaactct ttaagagagg atcaacaaat ctaatctaac aactagataatttcattagt

24181 tagaaacaat tacagaaaaa gatactttac agatctcttt tgtcaggcttcctaggatgt

24241 atcaagttat aggtggtcca cagagcaggc cctgtcccat ccatccgtgttccattagtt

24301 ggtttaggga actcatttct tctgccctaa attatccctc caggtcctctgcagagcttt

24361 cctgtgctct cctcctgaga acagatttct agcctctcgc ccttgagtttaatgaagctg

24421 aatcctttga cagaccacct ggtcagcttg gtcagctaat ttaacctgcctggccccagg

24481 gactttaagc tactccatga gggcagtgac cccattggtg ttgttcagctctgtcccaga

24541 gcacagagct catctcacag taagctctca gaaaacactt gttgaaggaataaaataccc

24601 aagcctatgt cattataaac aagccacaac aaaggccttg gttatctgatctcacttggt

24661 agcacagaag caattctgat gatattaaca aacctgaaaa agaaagggagtggagagatt

24721 ggaaaaaagc aagcagagtt ttaaagtggc cctgaggtga gcacagtgaaaggaagaggg

24781 acagagagat tgtgatatgc ccccttttga tctcctccct gcttcaatcctccattaagg

24841 ctgctgctcg tagttccctt tatcctattg agggtccata agttaggatcactcctaacc

24901 taggaccata cgttaggacc ataagttagt ccccaataac aatgccccattggacagcca

24961 aaaacagtgg ctccatgccc ttccctctac tccctttcct ggtagaaacatacaactttt

25021 ccttgtccag tcaacaccta agcgccccac taggattcac tcattctcccatcctgggtg

25081 ctttcttaac cagcagacac tatgagggcc agtcatgtgc ctctcttctcatgcaactgg

25141 tccttatctg caactcgtaa tctgcccagt tcctcactca tcctgcccaggcttctcttt

25201 tacctcttct gttatagtgg tgtgtgtgtg tctgtgtgta tgtgtgtgtgtgtgctcacg

25261 cacgtgtatg tgtaaaccca taacaagatt gacagctctg tcctctaaattttaatccct

25321 attcactctc ttgcctcctg tccttgccag ttccagaggt ccccttgttgtcatgtttgt

25381 tactctcttt tttcttttct tttctttaac agagtctcac tctgtcacccagcctggaat

25441 gcagtggcat gatctctgtg gtgtgtgtgt gtgggtgtgt gtgtgtgtgtataaacccat

25501 aacaagattg acggctctgt cctctaaatt ttaatcccta ttcactgtcttgcctcctgt

25561 cttcgtcagt tccagaggtc ctcttgttgt catgtttgtt actctttctttcattctctt

25621 tctttcttcc cttccttccc tcccttccct ccctttccta ccttccctcccttccctccc

25681 ttccctccct ttcctacctg cactcccttt cctccccttc ctaccttccctccctttcct

25741 ccccttcctt ccttccttcc tctctctctt ttttctttct ttctttctttctttctttct

25801 ttctttcttt ctttctttct tttctttctt tccttctttc tttctttttcttttcctttc

25861 tttccttttc tgaaacagaa cctcactctg tcacccagca tggaatgcagtggcatgatc

25921 tcggctcact gcaacctctg cctcccaggt tcaagcaatt ctcctgcctcagcctcctga

25981 gtagctggga caacaggcac acactgccat gcctggctaa tttttagtagagacggggtt

26041 tcaccatgtt ggccaggctg gcctcaaact cctgacctca ggcgatctgcctgcctcagc

26101 ctcccaaagt gctgggatta caggcactgt tatagacccc ttttgtcaggtttcctagga

26161 tgtatcaagt tataggtggc ccgcagaaca tgccctgtcc catcaatctgggttccattc

26221 attggtttgg ggaactcagg cctactgttg tttttaaagt atgtgctttgcagttgtact

26281 tgaaagtgtg gcacaggggc aaagccaaca aaaccacagg gtttttttcctggctgcttt

26341 ctgagggcta ctcttctcct ctagctggag tggtggtgca tttgccaagtgttcagaccc

26401 agtctgaagt actctggtat tctgtttggt attctgttta tgacgctggcctgtcgtttg

26461 tggaattttg ggcccttcag ggttcacttc tcccggtctt catcttttcagataagtgtg

26521 tgttcacatg ctcactccct tgggctcttc atagtgttgt cttatgatcaggcctgacat

26581 gcttggctgg ggccaaacag gcccactgag caaaaaattt ggagagttatatccacagaa

26641 ggagggcaag ggcaagggca aggacaaaag gcttacttac aggtcattagaagatatcca

26701 gacgggactt caattggttt ggggcaaata attggcacac ttagggttcagcaagacagc

26761 agacatgagt ggcaggagta tgacagactt agattctccc aatatataccaagaacctac

26821 tatatgtgta gacactaatt acttacttac acaagtgatt cctcattgaatcatatgaga

26881 agaatatata gtccccattt gacagctgag gaaactggga tgtggtgggtttaaataaca

26941 tgcctaaagt catttgagag tgattctggt cctttgactt aagtctttgcactttacact

27001 ttgcacacct ggataatcaa ggatcaggtc atatttggag aactaggcagccaggcaggc

27061 aaagtgcatt aggctgctat caaaactaag ctgtatgtga aactggaaagttatcctgac

27121 aagtccgagt gacctgaagt agggttgact gggtctcagg agcaagtcaggagcctgttt

27181 tgagaagtgt ggtcccaagt cacatcccaa ctagcaggtg atgtcatgctgagtcgccca

27241 actgttggat cagggtttcc aacatcctgt ctgtctacag atggggttcattccacagtc

27301 tcattgtggg gtaggatggg atataaggag aaaaggagtc tgaaaattaacctcactggt

27361 agggagagta aggctacaag ggcagagaac cagacagatc ttgttaggtaggaaatcgtc

27421 taatatctaa catttagacc tggacccact aactgacatc aagcaaatcacttcacgttt

27481 ccaggtctaa gttcctttat caacaagaca agacaagagt ggtggattcaacaataccta

27541 ggatgctttc tctatggttt tctctaagaa ccttatttct attttatttttaccactgtt

27601 ctctaattat aggggaaaat gtagtttcct tattaaagaa actttaggcataagtgatgt

27661 aggtcgggga gacctttcat ggctgggggc ctctggaatt ataccatatggatagtcatc

27721 aagatatagg tccatctccc aaattttcat atttgagaga acctcgtggtataatgtgta

27781 ggttaatttt tttatatggt ttgtagggta gctctggttt tgtcaaacagtagtcattgg

27841 accccacaat cactgagata ttttagtcac tatggagcgt tgtgataattacattaattt

27901 aatctttttt gccttaagaa gattttaaat gtcctggctc tcaaaggattttccactgag

27961 ctcttttagc ttcatacatt ctttgtctct ttaacagagc tgatacctcttcaaacacag

28021 taaatctcat attatggcta gaatctcttt taaattcaaa gaactttaagatggaattgt

28081 ggaaggagaa acactaacat gtgaaatggc atggatgggg ctgtatgatattaaagaatc

28141 agtaacagca gatttattca tgtgagagat agagaagagt cagcatggctaggctcaaaa

28201 atagaggaca aagaaatcag ccagtaagat aacaccaact tctgattaaacattataaaa

28261 gctgctacta tcatgtatgt atttcgtgtg ctttttgttc ttttggatcaagtactttca

28321 tgtctaatat gtgactgagc agatatagca tttgatgaga tggggaaaaaggatggtggt

28381 caaatcttca cagcattttt cacttaaaaa ctcactaggt ttttgcctcctgaacttcca

28441 cctgtgagct tgttctcgga gatgctggct gcatcatttt ccatcgctgtggtggcttat

28501 gctattgcag tgtcagtagg aaaagtatat gccaccaagt atgattacaccatcgatggg

28561 aaccaggtat gggtgccctt ttgctgaact ggttttatag ggctggaaacaggaaaaaaa

28621 cataaatgga aaagattttg gtgtcagcta aagaaggggt tggattctttcaccagacct

28681 tattgggttg gttttcctct tgtgtttgct aattagaaat tattttggaatagacacact

28741 gcatcacttt gcttttttaa gaaataagtt gaaataacac taattttaaaagagctaatt

28801 cagtcaggtc ataaataaca ttcaaagtga acatattagg tcagaaagagaattcttcat

28861 gtaacccagt acctcttggc aattattttt aacggcagtt ataatgtgacaaaacagtgc

28921 aacaaacatt aataatagtt gtgaccactt taaattgagg tggttcactgtgcagttaat

28981 atatacaggc aatttttgta ggcatgtgat acattgccag gtaagctgatttcacactgc

29041 ttgcaaattt gcaagttctg tatctatatg tttctgaaaa tacagtatagcaataacagt

29101 agttaaatgg ttagtaatca agcagaataa cagcactgct agtcataatatgcttcatag

29161 tgaatattca accacagaaa aacactttat gtgagagctg cagacattccattcactagg

29221 cagtgaaaaa gcttagcaaa tgatcaggtg ctatttcttg tcaactttaaaaattatcga

29281 gagcaatgag acctctctca gatggtatgg cgtccaaact cctgatgtcgtacaaggacc

29341 ccaagtacct atcacggtaa aaattaaatt ggaccaccac gcagagtaggcatgggagtt

29401 ttcattctta atgtacttcc tgaaatactc agcgaaggtc ttgcaaagattcaatttgta

29461 ggatcgttgt catccagtct cttccttagg aattcattgc ctttgggatcagcaacatct

29521 tctcaggatt cttctcttgt tttgtggcca ccactgctct ttcccgcacggccgtccagg

29581 agagcactgg aggaaagaca caggtaggaa caacagcctt atgatatccatctcagagaa

29641 caagtcgagg aatggcaaca gaggaaggct cgcaccgagc ttagcaggacaatttgcctt

29701 tcagacttgt acttcctaat ctgattcacc tcaggcctat tcctcttgttccactccctc

29761 acctgaaatc tcttaaaaaa caacatgtat ggttttctga tacagtgattctcaaatcta

29821 tttgtcagtg cttacctgtc atgtagctac acttacctgc tgtggtcaataacaactgac

29881 aaggaatcag taatgaagga tgctgatttt tgttaatttg ttacctggggagacagatgg

29941 cctggtaaaa gcgcttcctg gctttaggag ctattctatt ttcaggaaagtgaaaagctc

30001 tattcacatt tcctttagaa ggatcaggaa cttcctccag gggcgtttggtcccacagaa

30061 caacagtttg ctagccaaga atatttttgt tgtaacattt ttggcatttcttcctgagta

30121 agatttatgt tgttgaagtt ctgcatgtgg gtttaatctt atcttttaaatgtggtttgc

30181 agttgttgcc tttacaaggt ggccaaaaag ccagcatcct agttaatctctggataatcc

30241 ctccttcagt gttcagaaag ctcaggagcc atactcaaag gccactctttccagcaggac

30301 acagtcgaag agaccacacc aagcagatgg gcacaagaga cagactcaggaattttgctt

30361 ctgtctctta tgccttgagg tccttatctt cccaacacag aaagaactattatttaggag

30421 taagaagtgc attgagactc caaagaacaa caaacccaaa ctacatagtgcaatacacac

30481 acacacacac acacacacac acacacacat gcacacacac atgcacagtcttcacagtct

30541 tcaaatgggt tttactaagg cggggacact taaaaaataa atataagtcgggcacagtgg

30601 ctcatgcttg taatcccagc actttgggag gctgaggtgg gcggatcaattgaggtcagg

30661 agttcgagac taacatggcc aacatggtga aaccccttct ctactaaaaatgcaaaaatt

30721 agccaggtgt ggtggtagat gcctgtaatc ccagctactt gggaggctgaggcaggagaa

30781 tcacttgaac ctgggaggtg gaggttgcag tgagccaata tcgtgccactacattccagc

30841 ctgggcgaca agagctagac tctgtgtcaa atatatatat acacacacacacacacacac

30901 acacacacac aaacatatat atatatatat attctcatat atatatacgagaataactga

30961 aaaaactaat gactccaaca gtgacttgcc cagggagggc tttaattgtccccaatatgc

31021 atgtgatgct cctttcctat ttataatgga tcttgtgaca gacttggaagaattggcctc

31081 ttccagtttt ttggctgctt ttcaacaaaa aattttattt tcagaatttttcttaatttt

31141 ttattttttt tgcaaatatt tccagctctg agggagcagg taaaataatacagctcatat

31201 ccggaggcat agccagagat ctgtggtcaa ggggaagagg tcagagccaatttccaaagc

31261 tgtgcacatt tcaggctgca gctgtcagca gcaggaactt ctgctgctttcatttgagac

31321 ggagcactga caagctctcc agagcacatg gtcttcagcg ggtgcaggcaaatctcaaac

31381 tgctgatgtc cattctcctg atgttacctc caggctcaaa tgaggcatgggctggctgtc

31441 ccagtaagta tgcccatgta aagtgacctc cttggcacag ggtttgggggataatggtgc

31501 tctggtaagc taataccccc tgccacatac tggcatgtat tatatttaggaatgaaggat

31561 gccaggattt cagcattaaa gaatgaaacg agtaaagaaa tggcttcatgtttaattatt

31621 gaaatgtata ctaaattctg gggttaaaag tctaagtgcc tgaactgaaatccagggact

31681 gatggacaaa taaactggca gggcttctct tgtgtggctt ctcgtgttttctcttatgtt

31741 ggaacttcag tttcagcatc tacaaaatgg aaatgataat tgcatccatttcacagggat

31801 attgtgagga ttaggcaaga aaatgtaaag ccttagcaca tacttgtaaatgctcattgt

31861 ttcactcctt taggcaagaa tagcatctta gcatctatga tacatatattgtgcctggca

31921 cataagaagc acctggcata tatttgctga atgaatgaat ggaagaatgagtattggtgg

31981 acacgaactg tttttagcac atctacagat tgtagaagaa ttaaacattggaaccttttc

32041 tttccctcac ccccatctga cttccactga ctcacagaaa agtaattctgattacaaacc

32101 actctttagc tctgattacc ccctccctta acagaataat tttttagtaactgaatctgg

32161 ttgtagatat aaagtctaca gagtttctca caaacaagcc ttatcaagtaagtagaaata

32221 attgatcact caccaatttt aatatagtgg ccaaaatgag ccttggcctcccataattgg

32281 agactcatta tgacatataa ttggcaagta ggtggccact ctcctggcatgagtttggca

32341 gctgactgtg gtccttgtcc ccaaatctcc atatctttct ccagttcacagagctcccca

32401 tccacagtga gatgcaagtg gctcggtaaa tactggttga gtaattgcatgcaaggaagg

32461 aagggaggga taagggaagg aaagaaagaa gaaaatggaa ggaaggacaagggagaggaa

32521 gggaagggat atgaaggaaa gcgaagagaa gggagggaag taggatatcagcttctctgc

32581 ttagtcagga gaagggaaag agcaccaggg tactgggaat ctaggatggggataggaaga

32641 gcatagaaaa gccagccaga catacaaagc acgcttttta gtacctcatacacatcatat

32701 tgcctcaggc tgacccaact ataatctaaa tataaatgat caatttgccaggtagagcaa

32761 gtgctttcta attttctgtt tatatttgct gtgtctgtct cccgtaactcagaccttttg

32821 cactagacag tacttgtgct caacaaaatc ttcccagttg tttcctctctgattgctttg

32881 cttgtagttc cctgtctcct tttcttcttt gtttcagagc ttctaatcttcatcttggct

32941 ctgccccagc tgtctcaaca gagaattcat tggtcatcta atcaaacgagagagtagtcc

33001 ccaccccctc agcctctctc ctaactagta tggatcttag gagagctatttttgccagcg

33061 aaggtaaagt ttctgaagct tccttttacc cctgctattg ccccgttactccatagtcac

33121 tgtttcaggc tgccttgggg caaagctctg agcctgcctc cgtggaactgtcagaggagg

33181 caggagacac aatcccacct ctcaatgtgc aaatgtggca tttcgaatttgcaataggat

33241 gagtaaattt attttctctg agactttaat gagaccatgt gctacaagtacgaagtgtta

33301 tcagagttgc tattatagct gcagcttcaa taatgcagaa aaatcagctatgtgccatga

33361 gaatttattt cccaagaata cgacaatgat ctctgttgtt gggaaaggggggattggtcc

33421 atgtttcctg ccatggtaaa taactagaag cttggcctga atggacgccgaaaccgcagg

33481 tgtgtactat caccaaataa aatccctgtc aaactggctt taatttcataggatcagtcc

33541 ccatattttc tttaacttct ctgccatagc atatatagat gccatttttgttcagttttg

33601 tggcttgagc aaataactat cacttttctc gacagtattg agcagaagggggagacaggg

33661 aagtatgaag tgtgtctgtg aacaggctgt ctcatacaca catccagtgagctggaagac

33721 acaagggaga aggacgaatc cttttcatag gaggtgtgtg tcttccaggttgctggcatc

33781 atctctgctg cgattgtgat gatcgccatt cttgccctgg ggaagcttctggaacccttg

33841 cagaaggtat aaccctgctt ctctgcatac cgattgcata atttcccttcactactctgc

33901 taccagataa ataacaggag atttaacaat catcacatgg aaaaccattccctgaataac

33961 acagccttct ctgtctctct tggcagtcgg tcttggcagc tgttgtaattgccaacctga

34021 aagggatgtt tatgcagctg tgtgacattc ctcgtctgtg gagacagaataagattgatg

34081 ctgtaagtca cctaccacct atatttatct gaaataagat ttggttcttatatgcttcct

34141 gccatatcac tatattcccc ccatccccta agtctcactt gtgctttgggaactccagag

34201 gagaaattag aattgtgggg ataaatcaaa gccatgaagt cttccatgtgaactgcattt

34261 tgtgaagatt ctgtatctct gggaaggtca atttccagca agaatcccatatgaggctca

34321 ttcatacacc tttggccttc taaacacaaa aagcaaaaaa atgtttaaacaccctagttt

34381 agaaggacaa acaacataca aaacaatgca aaaacaaaatacaaaatgtaaaaacccacg

34441 ctgactttaa ctctgactaa cataaccttt gcaactattc tgagaaactaaaaatcagaa

34501 gctaaatcct tcagagttcc tctctaattt aaaccataaa aagaatgagaagacttccta

34561 catattgata tggaaaattt tccaagacaa atcgttaagt gaaaaagagaccagaataga

34621 aatgctgggg aaaagcacag acacaggcag aaataaaagc ggatacaaggagggagggaa

34681 gttgggaatg ggtggagaag ggggagggtt gtgagcaaga gttttcccctttttaatgat

34741 aattccctta tgaaccatac aaatatatta gctattcaaa aatttagaaataaataaaat

34801 gggacagttg gtcttaattg agaagcccag tttctacagc tacttaaatataaaatgaat

34861 gaagtcacaa tatttttaaa aagctgtgat ttggccaggc acagtggctcaggcctgtaa

34921 tcccagcaat ttgggaggca ggaggatcac ttgagctcag gaatttgagaccagcctgcg

34981 taacacagtg agaccttgtc tctactacaa ataaaagatt aaaaattagccgggtttggt

35041 ggtatgtact tgtgggtagt cccagctact tgggaggctg aggcgggaggatcacttgaa

35101 tccagaagat ggaggctgca gtgaactatc atggtgccac tgcactccagcctgggcaat

35161 agagtgtgac cctatctcaa aagaaaaaaa aaaatgtaat ttgtttgtggatcattgatc

35221 ttatttttat aggtagttat cacatgatgg tacctgatac attaatataattcttttcat

35281 ttctattttt ttccctaggt tatctgggtg tttacgtgta tagtgtccatcattctgggg

35341 ctggatctcg gtttactagc tggccttata tttggactgt tgactgtggtcctgagagtt

35401 cagttgtgag taacgtaaaa cccagatttc ctataaacag aacaacacactctgagcttc

35461 cttataccat tttgataaat atagtgaagc cactttcttt cgttatagttactgtatatt

35521 gagtgcttct atgcattaag cagacagtgt tttacagaca tacttaatcttcaaaaatag

35581 cctatgaata gttttgatta gtctcattct acaggtgaga aaagagaaattcagaaaagc

35641 taagaagcat ccctaagatc acacagctag tacgtggcag agctaagatttgaacctatg

35701 tacctactca tgtcctctac tgctgtgctc tccttttagt tgtggtaagactaaaaagta

35761 catagtttag ccaaaggctg aagttgcttt gtagtttctt ctttaaatgagatgaggaat

35821 gtaaggcgct cggccccagg cttgggacaa gacagctgtt atatattatagttcattttc

35881 ttttttaaag ctagtaacca aaagttacat aacccagaac aggaggactttaaaatagct

35941 gatgacagcc aaaattcatt caaatctctc atataaccaa taaggcatataaccaataaa

36001 ccacacaatt atgtgaagga aacaattagc tcatatgcag agtgaaggcagcaaagacat

36061 gatttaaata atggaaaaca gcctgtgagg gaaggtgagg agcctgaaggtggttttttg

36121 gttggttttg ttttgattct agagaggcct tagttaagtg ccctcctgggcctagagggg

36181 aacagagtct ttctctccct cctcaatgtg tccatcgtct ttccagacttctggcccctg

36241 ctctgcctgt gcttgggccg tgaaagaaga agacacctgg aaaaacatcaagatagatgt

36301 cttcagctta gcatccgctc acctctcctg tcccaccagc cagttctccttcctgccctc

36361 cttccctacc ttggcatatt ggtgcctacc caaaaggctt gtgttttctacctcagcatc

36421 ctaaatgatt gcccaagggc ctgagaaggt ttgcaggctc ccaaagttctcaatttgctt

36481 ctaggacacg tctcagaaac gctccttaga agatgctgtc tctcatgctgtatatgcctc

36541 agtgtctatt ttttcttgtg tggatgtggt tggaaaagaa gggttttacagagagagatt

36601 agcttataaa cttttaagtt aaaaatcagc acaaacctgt aagccaaggaataactggtg

36661 gcacatttta gctgctagtt tggtatctag gcttttagcc aacaaaaagcagtatcctcc

36721 acagtattta atttccagta attatcatgc tgatccagag agcacaatgctgaaagtaca

36781 ctaaacagat actctttctt caggaattgt atttagcatg tctctagtcacacatgaaga

36841 gtcacggaat ttatctgatt gcatcaggaa caagaaatca atagtctggttgacaggaag

36901 gacttatttc tggtcctcca gtctcctatt tctataaaaa atgactaagtcacaaagaag

36961 cgccaggcac tggaagaccc aggggttaaa gacagaggct ctgctgccctttacctccag

37021 gccttttctc acttctctta agaagtttag ttaacaataa aaatcaggataatactgatg

37081 acctttcagg gttatggcag ggcttaaata agatttcaca tgcgtgaaagctctatgctt

37141 atcctataac gtgttgtgca cgtgcaagta tgatgctcat tatttctctcagccatcaga

37201 agagaggcac agttctcccc tcccctgccg attccacaca aacaccagctgttcatttca

37261 gagttagcta caggaaaatg tcatctgcaa taaagacaga gtccaaaacaccagaatgat

37321 gggctcttta gtagctgttg tttttaactt tttattccaa aatacggctgttccaaaaaa

37381 tcttgacctt gatatttttt cttctagtcc ttcttggaat ggccttggaagcatccctag

37441 cacagatatc tacaaaagta ccaagaatta caaaaacgta agtacctttgtgagacattt

37501 gctggacttg ggtttactag cctgaagttt cagcagctcc attttacgtacaaggtagcc

37561 aaagggagaa aatgcctatt gggaaagtct gttagtccac agggagtgtcatgaaaactt

37621 ttgatccagt gcaccttctg acacccatgg cttatgtgaa ttttgtctatgctagctgaa

37681 tgtctttttt tttttttctt tttagatgga gtctcactct tcacccaggctggagtgcag

37741 aggcaggatc tcagctcact gcaacctctg cctcctgggt tcaagtgattctcttgtctc

37801 agcctccgag tggctgggat tacaggcagg tgccaccacg cctggctaatttttgtattt

37861 ttagtagaga tggggttgca ccatgttgcc caggctggtc tcaaactcctgagctcaagt

37921 gatttgcccg tcttggcctc ccaaagagtt gggattacag gcgtgagccactgcacctgg

37981 ctagctgaat gtcattttaa tataaaactg ttgtaagagg aatttaaaaataataggcaa

38041 tttctagatg ttcatccaaa attttgttta tctggtatat aattcttatcttctgtaaga

38101 ttttctttat tcagttctaa caagagatta tcaagttctc tatgaccaagaccttattat

38161 ttgacacttt gctttatcct tggtattaga agaaataaaa tatgacacaggaaatgaaaa

38221 acaaagaaat taaacatccc attgatggac ttgtgtcacc tgcaaataaaattgcttagt

38281 ggtgactagg ggaaacaaag ataaaaaagc agagaaagta aatcaagaaaatacaaattt

38341 agcaaataat aataataata atatcaaccc taggaagttg tagtctaattttaccttaac

38401 attaaaaaaa gttggacctt gaaactggga tttcagtagc tgctacttaatttatttccg

38461 tgatctttct gttatgttga gccaagtgcc attaagagct aaaatgatttagagattttt

38521 ttggctttgg ggagggagct ctaagctgag ttagggaatt ctgacttctaggctccatct

38581 tggtgagact ttgcccaagt cattcagcct ctcaggacct cagttttctcatctgaagca

38641 gctagactaa aattgctgat tcctgaagac tagaaaagtc tatgattctgtgattcctgg

38701 gttctatttt gggtgtggcc attgtatgtc agggtgagaa cagatgatatcataggcctc

38761 agttctgcaa atcccattga ttttgctttt tttctttgct acttttaaagaatgttagca

38821 aaatcaggag ggtcagtggt atgaacttca ggcaaatcat ggcactgttctaagcctcag

38881 tttcttttct ggaaatcaga gggttgaata aattgctttc taaggccctttctaactttg

38941 accttctatg agactgtaga ggtccaagag tttttgtaac ctgttgtctccctattcaag

39001 aaaagttgta gaggccgggc acggtggttc acacctgtaa tcccagcactttgggaggct

39061 gaggcgggtg aatcacttga ggtcaggagt ttgagaccaa cctggccaatgtggcaaaac

39121 tctgtctcta ctaaaaatgg aaaaattagc tgggtgtggt ggcagcacctgtaatcccaa

39181 ctacttggga ggctgaggca ggagaatccc ttgaacccag gaggtggaggttgcagtgag

39241 ccgacattgt gccactgtac tccagcctgc gcaacagagt gaaactccatctcaaaaaaa

39301 aaaaaaaaag aaaagaaaga aaagttgagt gctgctaccc agctcctctgagcaactgtg

39361 acttgactcc ttgctaagta gccagaaatg taattaaata cttgaggcttgaaattattt

39421 aatcccagac aatttctttt aatgccagat tgaagaacct caaggagtgaagattcttag

39481 attttccagt cctattttct atggcaatgt cgatggtttt aaaaaatgtatcaagtccac

39541 agtaagtatt ttatccctag aaatttgttt tctaacctct tttgagacttcattcattct

39601 acaagtattt actggggtcc aatcaggaat aggccctaga ccctcttccctttgtgtagg

39661 gcaatgagaa ttaaaatata acatccttgc cttcaaataa tttacagtctatttggggat

39721 taaaaaaaca catatgttaa aacccaggta gtaataacta tgccagacaaaaacattaga

39781 gatgtttcta ggcagaattt gagtaagttt caaataagta gtatagacagttgagagttc

39841 atagaaggaa gagatccagg ttagttggac taacaggctt tgtgcggcagttggctgaag

39901 gaaagaaatc atgtcaagtg tttgagaact atgtgagctg agagacagtggaaacatgta

39961 ttggaggtag ggttgcccag ttgcagcaaa aagtaaaata tactagtggaataaataagt

40021 agaaaatcct ggcaccaaat gccatgctat gctttgaact tggagtttgcctctaaatca

40081 gtgtttttct aagtgagttc cagggcaaac tgattcagag gaatgttcacagattttgca

40141 ataacaaaag ggctctgtga taccaaggga atttggaaaa cccagacttaaactaaagag

40201 ggtattttgg ggtgtgtgtg tgtttctgtt ttgtctttta ctgtcttggagcctttgata

40261 tgctactgtc ttctcagagc ttctgggtag gagtagggta gcctgggagtagacagagat

40321 ctactccatc agaccttaca atttcttttt tggcaggata gctcaaggaattataccctt

40381 tgagaaatag cctttccaga taacagttgc cattaataag ctttaggtgccaggcatttt

40441 aagtaacttg acatttattt ccaaaggttg gatttgatgc cattagagtatataataaga

40501 ggctgaaagc gctgaggaaa atacagaaac taataaaaag tggacaattaagagcaacaa

40561 aggtgagatg acatctttct tttccccctt aaattatttc ctttccctgatgagagcagt

40621 tagagggtct aaaattaaat ctatcctctt tagtatccag atgtgaatgaacaaatgaca

40681 tgtacgtatc aaagaacaac tgagctattc ttataggcaa gcgggagtggaagggaatga

40741 aataaaatca gcagcgctgc ctggaaacac aggatgtgat ttttttccccaccatgaaca

40801 gtgtctgcat tattttctat actttatttt tactgaaagg aacaaaataagtgcaaattc

40861 aatgccagaa aactacccac catagaaggc agtctaagtc cataaacttttggagctgtt

40921 aacttttact cagattcttc tggccagtgt atttcttggc aaagttccacaatcatccag

40981 aaaacaaaag tttcctggct cctctgttct cccagttttc ttcctagacaacatcaaagt

41041 ttgggctgag gtgaaaccca tccttaaaaa ttcatctcct tgatgtcttgcttaccaagg

41101 aacagtgtgt aggtcttttg gataatttga tatgaatggt tgaaagatttcaaatctttg

41161 acaattaagt tgacagtgtt ttcttcgttt agaatggcat cataagtgatgctgtttcaa

41221 caaataatgc ttttgagcct gatgaggata ttgaagatct ggaggaacttgatatcccaa

41281 ccaaggaaat agagattcaa gtggattgga actctgagct tccagtcaaagtgaacgttc

41341 ccaaagtgcc aatccatagc cttgtgcttg actgtggagc tatatctttcctggacgttg

41401 ttggagtgag atcactgcgg gtggtaaggt tctggttttc tgaattatacatttggagct

41461 ttggcaatag taaaatgatg tgggttgtcc agtattgcaa cagggcaaatacatgggctt

41521 tgtaattttt ctaggtgaat gcttttgtaa aaaagtgtaa tattttaaagcataggctct

41581 ggagccagac tacctggggg agatactggc ttcaccactt actagcagtacgaccctggg

41641 caagttgctt aatctgtcta tatctcagtt tcttcatctg taatatggaggtaatgatgg

41701 tatctacctt cacaggttgt tacaaggatt aaataagcta atagatataaggtgtttaga

41761 agagtgtctg gttcaggctg ggcatggtgg ctcacgcctg taatcccagcacttcgggag

41821 gctgaggcag gtggatcatg aggtcaggag ttcaagacca gcctggccaatatggtgaaa

41881 ccccgtctct accaaaaata caaaaattag ctgggcatgg tggcgcacacctgtagtccc

41941 agctcctagg aggctgtggc aggagaatcg cttgaacccg ggaggtggaggttgcagctg

42001 agattgtgcc actgtactcc agcctgggtg acagagtgag acttcatctcaaaaaaaaaa

42061 aaaaaaaaga atatctggtt caaagatact ccccagcaaa ttaattcacatttattatgt

42121 tttatctttc tgagaatgta taacaagtgg tatatgaaaa gaaaaaaatgggcaaaagtt

42181 tattaagtat tacatttcta tttgttatgt taacagcaac aggataaggaataccaggtg

42241 tatgttagga ctggaaaagc caggcattat taagaggtta gagtaggaagcaggtcagac

42301 atctggaagg tcaaagcaag agttgaggag tatgcaggat agaaacattaatgatatcag

42361 aaaccagtta tgcaagctga agttcattaa ttctgtcaac aaatagatgtgaaatgccta

42421 atgtgtactg agcactctgc caggcacaag agactagtga tgaagtagacacagtttcta

42481 cctacgtggg acttagcagt ctggaggaga aggcaaacat taagtcatcttataaataac

42541 aattgtagta agtgctccaa agaagatgaa taggacatca cctgaagcatcaagttcagt

42601 gaagcttcag gtaggtatca aaagggtcag gcagaaaagt aagcaggtcaagacaccaac

42661 aatcagatgt aataatataa agctgactcc taactgaggt tccacttagctaaggcttct

42721 ttgctacctc tataagggga ggaaatgatt ccaggatgtg ggtactaggtaggtagggta

42781 gagaagtgat tgtgcttggc aaaagagtat gagaatatgc tgacaggttctgttctagtt

42841 ctcttagcag attttgttat tagctcattt gaaatcactc ttgttctttgttgtacattt

42901 cactctaagc attggctgag atccattgta gactatattg gccagagagttcaatgaatt

42961 acttttgggg acagtcttaa catatttaat gccagaatat ttcccacacaacgaatattt

43021 actttcaaat attataatga cagttatgat agctaaagaa gactccaaactttatacttg

43081 aacagaggtc ttgatttgtt ttcctccata attctcaaat tctcttttattattgactat

43141 gggtcttgtg tcttgacttt ttaaaattaa atgtttattt tgacataattgtaaattcac

43201 atgtagttgt aaggaataat atttagatcc tatatacccc ttacccagtttctcccaatg

43261 agtaacatct tgtaaaactg tagcataaaa tcacagtagg acactgacattcaaaataga

43321 ggccttgact tttaggtcaa tagtaacatt ttgaacccga taagcatagccacacccata

43381 tctcttctcc aatcagcagg gcctatatta agaagcctcc tgtactctcttctttccaca

43441 aatgcttatt tagcacctcc acgctatcaa gtgctgtgct attgagcgctggatgttgcc

43501 atctcttgag atataatcct aattatacca ttactgtagt ttgaaaacctccatggtttt

43561 gcaataataa cctttcctta aagtcctgat taaccatgaa agtaataatgtttctcctga

43621 gcaagtaact gaatgctact gaattatggg cagataaggt tgttaattgttacaaactct

43681 ccttttttat ttttagattg tcaaagaatt ccaaagaatt gatgtgaatgtgtattttgc

43741 atcacttcaa ggtaaataca tatatctaca tatctacctg taagactttcccgtaagccc

43801 tttctcctat ctgggactgt ggtcacatta tgtctgaagg ccttttttttttttctttta

43861 aagatctcaa ttgtcattat ttgcagttct ggaatctggc actgcttcattccataaaac

43921 agaataagtg ttccaaggaa ctaagcagga gttcagtatt atacacagaaaaggccaaag

43981 acagcaaaag caagcaacaa agagtatatt agtccattca aagttactttcttgtaagtc

44041 agagacagtg agacagaaca ataggaaaat aatggattag ttaacatgaggtcatgtcag

44101 gatacttttt tgtatgagga ttattgcaga ggaagcttta ttattatgccaactggaaat

44161 ttaaactgtc ctgttttagg aaatttgcta ttacctctct ctcctgatttcttcaagtat

44221 cagataacaa tttagtttag gtttgataac ttgaaacttt agcatgagtgactccatttt

44281 gatttttagt cttgtctgtt gtcgtctagt gcgggagctt agtctaaaacaatggccttt

44341 tatttttatt ttttatttta ctatgtgcct gtgccttgca tgaccccaggatgggcacag

44401 ctgcttggcc cctgagccac cgaaggctgc tctactcctt cgttctggctactaaaagct

44461 gcaaagctct gggagggcaa agctcaagaa gactaaaaca atggcctttaccatttttgt

44521 ttgatgattt tccccgtttt gatcaggctc tcacctaggt aagagtgaacaaaatgtagg

44581 agatcagtgc tactctgtta ccatcatttt gggtttctgg tctcaggaggtcatgtgtag

44641 cttatggtgc cctcctcatt atcatgtatg tctctgagtt tttgttgtttcagagagaga

44701 ccattcgatg tctgacaggt ggctttttgg aaacatttaa aactttgagagggtataatg

44761 taccaggaag actgctatta tgactatcag ggagataata ccaagggtttatagtatgct

44821 ccttagccag gattctcatg aatcaaacca actaaaattg aatagcctgacaaggagact

44881 acctgtttta accaagaagt cttctctgta gtacctgatg tatttatatatgtggaacaa

44941 gaagtgtcac ccaactgcac agatgcttcc ttgttgagtt agcaggtaatctagcattcc

45001 atgactggtt aaattaaagc agaaagtgta agttacccaa agaagctactcattgtgaag

45061 ttttaactac agcactatcc tgccaagtga aagaggtagg cacaagtaagggaaaattaa

45121 aagggataag catcttatga tagggagtct tgttctgaca gtcttggagctgtctacagc

45181 atgaagttga caacttcttg ttttggtttg tagttttatt gtctctagttgtggcatcca

45241 gcattctggc gaactctcta tgtggcccac agtttaagca tgagattcatctcttgaaat

45301 ttacactgag ttgctcagct tcagcttaca gagcttcagg aactgagtagttcttggtct

45361 tcattggagt gttgtagcca gatattagtg aaagctaaaa gaattaagaatccagctcag

45421 tctacaggta gataataaaa actcataaat attgaacagg gctacagtctaagaacagtt

45481 ttactatgct tttcttttga accatatgtt tttctttcta tagtcacctccatttctatc

45541 aaagacgatc atggtagacc aatttgttta caaaataagt ttggtctcaaacttggcctg

45601 attgattatt tacacagtac agcaagaata actacatagg tgactcctttcaaatttgct

45661 ttgccaagcc tggcgaggta ttgcttgcct gtgagcccag ctacttgggaggctgaggtg

45721 agaggattgc ttgagcccag gaattcaagg ctgcagtgca ctatgattgtgcctgtgaat

45781 agccactgca ctatagcctg gacaacacag tgagaccatg tctccaaaaaataattgctt

45841 tgatagaaat tttgacaagg aatctcagat tggacttttt aaaacgtcttgatgctatga

45901 agtcaaacca aggcagacat taggctttgc ctgatgtatc taatatcttgaagttactgg

45961 gcctcccagg aaggaacgac tttttattca ctcattgtaa ggctagcagcccttgaagcc

46021 aggaattctg tgcacatttt caaatatgat attctattca aagccttgataatataacca

46081 atgttttcca attgtattct atttaaaaga acagattcta ttgaactttcatgtaaataa

46141 tcatattgcc ataaaaataa gaatactcac aaagagtttc caaattctggaaggatcagg

46201 tagagaggaa aagcaaatgt ttcaattttt gtttatgaaa gtatgcttaacaaggctggg

46261 tgcggtggct cacatctgta atcccagcac tttgggaagc caaggcggacaattgctttg

46321 agctcagagt ttgagaccag cctggcaaca tggcaaaacg ccgttactacaaaaaataca

46381 aaaaattagc tgggcatgga gcctgaggct gagaatcact tgagctggggaagtggaggt

46441 agcagtgagc ccagatggtg ccactgcact ccaacctggg tgacagagtgagaccctgtc

46501 tcaaaaaata aaaaaaaagt atgcttaacc aagtggctgt aaactgcagatagctttaaa

46561 gaaaaatttt ctttagatct ggaaaacaaa tattaaaaga accagcaatgtttcaaataa

46621 aaaagccata aaacctgtaa ttcttctcca tcagttcatt cagtctcatgtaattaattc

46681 ttgctctgtt tgatcttggc tggtagttta attccaacga atggtatgaattcaaagtta

46741 ttagaaacct gtatttgtca gagttctttt cattcttccc atataactctttgaagtcac

46801 agcactttag aattataatg gcttacaaag agctttcaga aaaagtatcagaacaaaaca

46861 attaactgtg gacaacaaga cttaaagtgg ctatatttaa agatctgatgtgagttaccc

46921 aattgacaag gatatttgga tatttctgtg gcacacaaca atttaaaataaccaaaatta

46981 tgactggtag catttatacc aagacctatc acatttctag gaatgttatataattttgga

47041 acatattaat aacatatcta taaaaatata gcacaaagaa agttaaacatcatttcttat

47101 tttaacagtg cttcccatat aatttaacct atcagataag gccatttggtttaacatctc

47161 tcttttacag attctttaag aaattccagg gtcctctgga acatcccaaagttagttcaa

47221 ggtcaaaaag acttaatttt gatttttgag aagtttgtca aataccaaaggtttaaaaca

47281 tttgatcaaa atcggatcat aggtcactat gaaataaaac caaagtgaaaaaagagttca

47341 aaggcaaaaa gcacaagaag agttatattg atgaaacatg aaatctctgttttctaggcc

47401 agttacctgg aagagaaaat cctctcacaa ttttctatta agagtaaaccaatcctctga

47461 gaaaactcta ttgttccaac acataggccc acactttagc cttccatcagtgtactttaa

47521 tattaatgct caatttttag aaaaacttat aaataattcc cttctacttttagccaactc

47581 aatcacataa aatttttcat gatatttatc ttctacaaac cttctacaacttgcttaaac

47641 cttcatttgg tcctatactt ccttttttaa aattggcatt gtaccttaggacaaagattt

47701 acttttcttt tctccttatc attttgacca tataaggtta tctcctatacaaaagaaaaa

47761 attactctct tttcaatttt ctttatctct tcatacttgt aaatttcttctcacatcttt

47821 cctacctagt ggttccttcc tgccttgttt tgatttcctt cataagtccatatttagaaa

47881 caacctttaa ataacctctg attgccaagc tagagttaag ttttaaataaataaataggc

47941 cggtcatggc ggctcacatc tgtaatccca gcactttggg aggcaaaggtcagaggatca

48001 cttcaggcca ggagtttgag accagcctga gcaacatggt gagaccccgtctctattatt

48061 ttttttttaa aaaacaaaaa gcataaaaac tctgagaaca ttttgaacccagaaagatat

48121 tacttccaat ttgtgccaca gagctggtaa tgtatggaaa tgtgtatcttgacagtgggt

48181 gggggtgggg tgaatattga caatgggggg atgttgttat gaggagagcaaagctggaga

48241 ttacttagat tccttagaac aggaggactc tcaagggtgt gagtctctgtgtgtttcttt

48301 atgaatgtat gtgtgtagga aagtgctaag gcttaggttg aattctttagcagcagagcc

48361 caagatgggg attcttgcac aagcgattta ttgagaatac atctgaggaaatttatgaag

48421 cagtgagggg agcaggatag ggaaggggaa gaagctgatc aaagacatggtttctgaagt

48481 ccagcgtaga tccctgattt cacagggagc accaccacag gaagagtaccagaaggttat

48541 gcctccttga ggcaagagga cctgctttct cccccagtaa tgagtcagtcagtggctgca

48601 ggccagccat gtgtggggat gaaacctccc agttctcttt atttacttatttatttgaga

48661 cagggtcttg ctctgtcacc caggctggag tgcagtggtg caactgtggctcactgcagc

48721 ctcaaactcc tgggctcaag tgatcctccc atctcagcct cctgagtagctgagactata

48781 ggtgcacaac cacacctggc taatttttgt atttttttat aaagatggggtttcaccata

48841 ttgcccagaa gttctgggtt caaagtgatc tgccctcctc ggcctctcaaagtgctggaa

48901 ttacagaccc agtcctcttt agatgacaca gctcccaacg ggcaagggaaagtctccaga

48961 gaagggcaca gctgtgaaac attggcagcc tggcccacag cagcaggaggatggatacac

49021 tggcttggcc aaagggacgt gatcgtccac aaggttgact acgaccagttatgggataac

49081 cattctatat actactggaa aagaaactgt catttcaaat ctgggtcacattttggataa

49141 gagaaaaata aataaataaa aggaggagct acaaaaactt agtataggttgatgctttaa

49201 aatttctttt cttagctggg catggtaggg tgtgccctgt agtcctagctaattgggagg

49261 gtgaggtggg gggatcactt gaacttggga cgcggaggtt gcagtgagcaatgatgccac

49321 tgcactccag cctgggcaat agaatgagac tctgtctcaa aaacaaacaaaaatttcttt

49381 tcctaggaac taacaaaaca ttgtgtcttt cttttgaaga ttatgtgatagaaaagctgg

49441 agcaatgcgg gttctttgac gacaacatta gaaaggacac attctttttgacggtccatg

49501 atgctatact ctatctacag aaccaagtga aatctcaaga gggtcaaggttccattttag

49561 aaacggtaaa tattcaacct ttctacagat gtatcttttc taaactatcatgatttctat

49621 aaatggcaaa cattacacaa gtctagtcta gctgttgaat tttaagctacctatataact

49681 tcatggagcc tcagtttttt catcagtaaa atggaagtaa aaacattaaccttgctaggt

49741 agatatgaag actaaataag atagtttata ggaaattacc tggtagtacccagtactgaa

49801 tagttctaca atgtgtaggt ttattaataa aagtgggcat tagctataatgccttttaag

49861 aatattgaat cttggatctt ttgtgatctg ggatttgtgt acataaattccacttaaatt

49921 ctcagcaatc tggaaaacct tgaattataa atgtctttaa acaggatccaccaggccata

49981 agtgatcttt gaaaaagaaa tttaaaaatc aagccacaaa gaagcccagggttaattttt

50041 ccctacaaaa tagaataggc cctgatggga ggcctcatgg cacaacagtagcgcatctgg

50101 ctccagaata ggccctgatt tcccatgggt attattttgt taatttttctgtcaaatacc

50161 cagaagaggt gagcattctg gtctggttca ttgggcttgg cctaatggtgctcctggtgg

50221 tacaagaatc tcatttctca tagtgaattt aggaaactaa agcaaatacctatcaagata

50281 taataacagt aatgattcca gtgacatcgt ggatatttta aattgcttcccatttttcta

50341 aaagtagaat aagtagatcc ttattgtaga ttggcagttg attgaagaaaactaacttag

50401 gaaatgatat tatattattc tttttaggca ctggtagtgg agagattgttctatttgatg

50461 ttccttggta aaatactagt cctaactacc aagctgtgga tcttaaatataaaaaaggaa

50521 aaaaaaaaaa gagtaaagct acaaatctaa agaaaaaaaa actgtttatcattgaaaatt

50581 cataaacttt ttctatccaa cttaaaattc tctaacccat aggtgataagaaagttggat

50641 catatgaagt atcctttaag agatccacat taaaagtaaa acagaaccaaggtatcaagt

50701 tctttctcaa catgaaagca gttattttat ttgtttatac ccattcttactaagatttta

50761 ggctatgaat gtcataaaaa ccactaacca agagtgtatc tactaggttagactcactct

50821 tgtttgcaat cagagaggta ttgtgagtgg ctgggatgga tttttttggaccttaaacaa

50881 atagactaag cataacggaa tgcttgtatt acatacttac tggtccactaaaagtgggtt

50941 ggacattcct ggtggcctgt gagatcaaga ggcttatatt tctgtgtcttctcagagtct

51001 agcacaaagc tttatatgtg ataagtaggt gaatgatgat aaactccttcaagagggagt

51061 ccctctgtat caaagatatt gtgactgcaa tgacacaacc ttcttcctatccctttattt

51121 taccatcaca ggactatctc aggacacaac ttgtagttag acttatcctctacctttccc

51181 attatgtcat accatttgca cagggactta accctctaat tcattctcatactagctaag

51241 agaattgggc tatttgtgag ttgaaaagta gctaagtagc atttcaaaatgttattttag

51301 cctggatata tatttggagt tgctttgaaa atgtcctttt ccatgcaaaacacaaagcca

51361 aaattgtcgt tggtttcctc tgtgtagaag attaaattac atgccacctctaaacagtag

51421 agcttttctg aataaccaac ttggtccata gacattggtt tccatctccaatagaattaa

51481 tttccaccca attccatttg tggctgtttt ttgtcatcag tgacaagctcttcactgtgc

51541 attcattgca cactcaacgc tgtgctaagt gctcttagct tagccattgagagatgcact

51601 attgactgct gaatcattta ggcagagggg gtgacttgtt aagaggcatacactcaagag

51661 gttggggaag agagctgaaa aggagtttac acaatggaga actataccagttcacctttc

51721 aatgtgcaaa aaaatgatat acaaaaaatt ttagttggga aatataaaagaacaatacag

51781 ctgaagagga ttctgaagta tgtaaagaca gatgagaagc accaggaaagcttcaaatca

51841 ttttcagtgg agcatcaggt gggttgatgc tattctattt ctaccctgtgttctcttttt

51901 caagatcact ctcattcagg attgtaaaga tacccttgaa ttaatagaaacagagctgac

51961 ggaagaagaa cttgatgtcc aggatgaggt atgatcattt tcttctgaagaaaatatttg

52021 aattacattt tgaataatta gagtaataca aatagtgaat atatctgattaagaactgtc

52081 agggaacata attcccccaa atgcagaaaa gatggcttca tagcagggaaaaagagaaaa

52141 taagaattct cccttgaaga cattaagtac ttggggatct tttgtcccaggcatttgggg

52201 atgatcagca actggcaaga gccaacacac tgctcctgat ttgatacctacacctctgca

52261 tactgctctt ctagagatgt aaggccatgg ggtaggaaaa aaatgaatagaggaaacttc

52321 taagctagga actttataag cctcaggaat agtatgtgag gaacagaaaccctatgacct

52381 tccttcatat gactgataaa ggctttaaaa acacactctc cccaccctagactgattctg

52441 tgtatttcag atgctcttgt gacatcagac tattcctagg aaacttgtctgaacttgtag

52501 catctgagta aattttgcag cttcgccact ggataagagg tgaacactgaaggaagatca

52561 cagaattgta aaaagttgaa agatttctta gaatcaagta gtctaacattctagcccatg

52621 cagaaatcct tcctacacca tccttgatga atgttcattc agcttttatgtgaacatttc

52681 cagacattgg ccactagcgg cttctcaagg gagtttgtta catggttggaagtctctaaa

52741 tgttacttgt gcttacagaa ctcaatttgg cctttctgta gtaaccacctagtgaactga

52801 gatctgcctt ccttagcaac acagaccttc ccactgaaca gcccttcaaatatttgagaa

52861 tagttctcat gtctccagca gactctcttc cagttgagac tcttctagttccttctattc

52921 cttacaaaca agcagtcagt gcttctctgg tcacgatggg gacacaaaaccctaaatgcg

52981 gccaggccag catggagatt attcaaccat gacctacctt gatctcatcaagatattcct

53041 attactacag cttaaaaatg tgtttccttt cataatagca acatcagaattttagcttct

53101 attgagcagg ggccaactaa agactggggc attttcatac aagctatggtctagtagagt

53161 tccctagtta tatttattta attgagcttt gaccctaata cagaactacacctatttctg

53221 ctggatttca tcttgttggt tcttgtttac tgacataatt ttgtattattattagtatta

53281 ttattattat tattatttgt gactgagtct tactctgtca cctggactggagtgcagtgg

53341 tacaatctca gctcactgca atccctccct cccaggttca agagattctcacgtgtgcct

53401 cagcttccca agtagttggg attacaggcg ctcgccacca cgtccagataattttttttt

53461 tttgtattct tagtagagac agggttttgc catgttgtcc aggctggtcttgaactcctg

53521 acctcaagta atccacctgc cttgccctcc cagattgctg ggattacaggcatgagccac

53581 cacattggcc agttttgtgt tttgaatcta acatccagga tattgtctaccccagtaccc

53641 gttacctggt gtcataatca aatctgataa gcctgccttc tctgcctttttctaggtctt

53701 gaaaaaatgt tgcaaagaaa acattcaacc ccctatagtg aaatcaggcagtaaggatga

53761 caggcagaga tttctgtgga ggaaatacat tgctagagtg aaaatcacagtacctgcatc

53821 ttggcccacc agcttagtga gcccaggaaa gtcattatcg acctgagaagtccttttagc

53881 tccagtagtt tatgactcta tggatatagg gtgccttagt ttgagtaaaaactcatatgt

53941 caacattaaa acttaagact gctatattat aggatattta ttggttgccacgtaaaataa

54001 tcattcaggg agggtttcta tagatggtaa aacaatatag cacaatagtttcaagggcat

54061 ggactttaga acaagacaga cctgggtgct agtcctcatt ctgctacttactggctgtgc

54121 accccagggc aaattactta tcctgtcttc atattagtat cttcatgtaaagtagtaata

54181 ataccacaga gttgtgaaaa ttaaaggata aatgtaaagt aacaagagcagtgccttgta

54241 catagtaagt gctcaataaa tagtaatcat tgctcttaaa taaatccaattaaagtgtga

54301 tgaatacagg ccaggctcag tgactcaagc ctgtaatccc agcactttgggaggctgagg

54361 cagggggatc acttgaggtc aggagtttga gaccagcctg actaacatggtaaccccccg

54421 accatctcta ctaaaaaaaa aaaaaaaaaa attagctggg tgtggtggcaggcacctgta

54481 atcccagcta ctcgggaggc tgaggcagga gaattgcttg aacctgggaggcagaggttg

54541 cagtgagctg agatcacgcc acagcactcc agcctgggca acagtgagtgagattcagtc

54601 tccaaaaaaa aaaaaaagta taatgaatac gaaatgaagt ttttaccctatttctattgt

54661 gatgatatac acctaagatg agtagcagta agcaatcaat actataaaaacatatttata

54721 aaaaagataa tgcagactta aggagaattc agttgtatca acactttgttttccccttgc

54781 ttccacaggc tatgcgtaca cttgcatcct gaaagtgggt tcgggaggtctctatgagca

54841 aggaatacaa gacaaaactt cctcaatgca ttgactattt cttcagactcaaaacactca

54901 ttcttttttc tattaagcca ttgaaagaga agcactaaga ctgcttctaggctttattta

54961 taaaataaac accttatccc taacatgggc aaaatggcta gaattattcagacgatttgg

55021 cagcgtccag ggtaagctgg tgttataata cgctgctgat ctacatcacagatttgctaa

55081 taatgttcac gtgggccctg gcatatctct gttcagttag agtgagtgctgacccaacag

55141 cctctgtggt caagcgagtc acgaatgatt aatcataaag aaaaatcagtttttgactga

55201 cctggatatc catgagctgc actgatcacc atgtaaggtc acatttagtaaatgctgaaa

55261 taaaatgatt aatgcattta tcaataaaag cctttgaaaa tactttggataataaattgg

55321 agttttaaaa atgcaaattt gcttagtatc taataatgaa gtgttattacatatagccgg

55381 aattgaggat ctctttgatc ctggaaatgg tttacctaaa agctacagaaccaggccaat

55441 atattttgaa atattgatgc agacaaatga aataataaag agattttcatggtttataaa

55501 aatctttttt gatatgataa taatcatgat cacaactgag atcaaaaaaatatatgacag

55561 attattttgt ttaaaaatgc agttttaatt atcttagtct atagaaatgatcattgcatg

55621 gaggcatgta taggtatgat ctgtgtaaaa tctgacataa aaacagtgctattctgagtg

55681 aaaatttttt tgatgtgctt acataaccat ggtgattaaa atgagtttatattttttctc

55741 aaaaatttta gcagtgtgta aagtaagtaa tctttaactg aactctgaccacttaaaaaa

55801 aaatctaaaa attgaactac ctatagtagt ctgtgtttaa agtgaatttttaaagacaaa

55861 gcattctaaa tgaactcaat ataaaaacat tcatttggaa tgtacatactgaaaaataca

55921 ggtttttttg accaaaagtt tttatatctt ttctttttat ttatttttttcctaagtgcc

55981 aacaattttc tagatattat atacaacaca ggctttgatc ttggggacttttcccatata

56041 tttcacactg gagtgaatga agttgtactt catttctaga gaaaagttatacccaggtcc

56101 ccaattgaga atgtcttgct tgattgaaaa cgacatcatc ccttggtatactccagggat

56161 tggtttcagg acccctgcat ttaccaaaat ttgtgcacac tcaagtcctgcagtcacccc

56221 tgcctaaaga tagaatggct tctctgtttt tcttctgaaa tacaaccagaaacaatgtgt

56281 ctatttctga aagaatagga ttaatgatca tacaaatggg ttaatcctgaattctggttg

56341 taaatctggt tacagcataa ctaggattat aatgctgcct cattttcacagcactacttg

56401 cttatattga caacaaatca tctcgctaaa gagtgaatgt aggccaggcgcggtggctca

56461 tgcctgtaat cccagcactt tgggaggccg aggcgggtgg atcacgaggtcaggagatcg

56521 agaccatcct ggctaacatg gtaaaacccc gtctctacta aaaatagaaaaaaagaaatt

56581 agcctagcgt ggtggctggc gggcgcctgt agtcccagct atttgggaggctaaggcagg

56641 agaatggcgt gaacccggga ggcggagctt gcagtgagcc gaggtcgtgccactgcactc

56701 cagcctgggc gacagagcaa gactccgtct caaaaaaaaa aaaaaaaaaaaaaaaagagt

56761 gaatgtaata gtcttgcaga aaatgaatga atacctttgt tcaataaaggaaatatgcac

56821 tgctcacttt tttgaaggaa atgccaaagt tacgttttac aacaaggctagagtttgtaa

56881 attctgggtt catttgtgat gacataagtc agcaaactgc gggaatactgtctcttctat

56941 gtattttgtg aatagtaagc ataattttag ttttgtatta tcaatgaaaatttcacttga

57001 aattaaagct gccttttgtt atatttttaa cctataggat aagattccagtattgtatat

57061 gagttttaac aaattaaaaa atcaaatcat gtacatttga aaatatttgcacacatttaa

57121 aaataaatgt aaagttgtct tttaaactac tcggatgtgt cctttctgaa caaaa

耳畸蛋白

迄今为止，已经鉴定出人OTOF基因中的数百个突变引起了严重的语前性耳聋DFNB9。此类突变是导致不同人群中2-8％的先天具有常染色体隐性遗传性非综合征性聋人耳聋的原因(Rodríguez-Ballesteros等人(2008)Hum.Mutat.29 823–831；Choi等人(2009)Clinical Genetics 75 237–243；Duman等人(2011)Genet Test Mol Biomarkers 15 29–33；Varga等人(2006)J Med Genet 43576–581；Iwasa等人(2013)BMC Med.Genet.14 95)。例如，耳畸蛋白的保守C2C结构域中位置490和515处的外显子15中的两个取代导致DFNB9(Mirqhomizadeh等人(2002)Neurobiol.Dis.10(2):157-164)。Migliosi等人在患有语前聋非综合征性听力损失的西班牙患者中发现了OTOF中的新型突变Q829X(Migliosi等人(2002)J.Med.Genet.39(7):502-506)。

患有听力损失的受试者中检测到的耳畸蛋白基因中的其它示例性突变和编码耳畸蛋白的核酸的测序方法描述于例如Rodriguez-Ballesteros等人(2003)Hum Mutat.22:451-456；Wang等人(2010)BMC Med Genet.11:79；Yildirim-Baylan等人(2014)Int.J.Pediatr.Otorhinolaryngol 78:950-953；Choi等人(2009)Clin.Genet.75(3):237-243和Marlin等人(2010)Biochem Biophys Res Commun 394:737-742中。

至少在生命的最初十年，DFNB9患者的耳声发射正常，表明内耳的形态完整性和外毛细胞的正常功能。除了缺乏突触传递和随后的突触损失以外，至少在人生命的最初十年中，DFNB9中保留了内耳的形态学和生理学。

对小鼠模型的研究表明，突触在结构上是正常的，并且IHC在出生后第一周内在小鼠中保持正常的突触数量。在P6与P15之间，约有一半的突触丢失(Roux等人(2006)Cell127 277–289)。动物模型允许通过记录囊泡融合后质膜电容的变化和听神经的活性来研究耳畸蛋白中的突变对突触传递的影响。在耳畸蛋白敲除(Otof-/-)小鼠中，通过去极化诱导的Ca2+通过电压门控的Ca2+通道流入，IHC中几乎没有胞吐作用被触发(Roux等人(2006)Cell 127 277–289)。在C2F结构域中存在随机点突变的严重听力受损的pachanga(Otof

检测基因中的突变的方法是本领域公知的。此类技术的非限制性实例包括：实时聚合酶链式反应(RT-PCR)、PCR、测序、Southern印迹和Northern印迹。

OTOF基因编码耳畸蛋白，一种在耳蜗毛细胞中参与突触囊泡胞吐作用的蛋白质(参见，例如，Johnson和Chapman(2010)J.Cell Biol.191(1):187-198；和Heidrych等人(2008)Hum.Mol.Genet.17:3814-3821)。

人OTOF基因位于染色体2p23.3上。其包含48个外显子，涵盖约132千碱基(kb)(NCBI登录号NG009937.1)。编码在大脑中表达的耳畸蛋白的长形式的mRNA包含48个外显子(Yasunaga等人，Am.J.Hum.Genet.67:591-600,2000)。Yasunaga等人，Am.J.Hum.Genet.67:591-600,2000的表2中描述了可用于扩增OTOF基因中的48个外显子中的每一个的正向和反向引物。在一些实例中，全长OTOF蛋白是全长野生型OTOF蛋白。从人OTOF基因表达的全长野生型OTOF蛋白的长度为1997个氨基酸。

示例性人野生型耳畸蛋白为或包括SEQ ID NO:8-12中的任一个的序列。人耳畸蛋白的异型体e(SEQ ID NO:12)由mRNA编码，所述mRNA包含耳畸蛋白基因的外显子48，并且不包含其外显子47(Yasunaga等人，Am.J.Hum.Genet.67:591-600,2000)。在一些实施方案中，活性耳畸蛋白具有SEQ ID NO:12的序列，但缺失包括Strenzke等人，EMBO J.35(23):2499-2615,2016)中鉴定的RXR基序的20个氨基酸。编码野生型耳畸蛋白的核酸的非限制性实例为或包括SEQ ID NO:13-17中的任一个。如本领域中可理解的，可对SEQ ID NO:13-17中的至少一些或全部密码子进行密码子优化以允许在非人类哺乳动物或人中的最佳表达。人耳畸蛋白的直向同源物是本领域已知的。

人规范(长)异型体序列(耳畸蛋白)(SEQ ID NO:8)(也称为耳畸蛋白异型体a)(NCBI登录号AAD26117.1)

MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDPLAAFELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA

人异型体2(短1)(耳畸蛋白)(SEQ ID NO:9)(也称为耳畸蛋白异型体d)(NCBI登录号NP_919304.1)

MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLLGA

人异型体3(短2)(耳畸蛋白)(SEQ ID NO:10)(也称为耳畸蛋白异型体c)(NCBI登录号NP_919303.1)

MMTDTQDGPSESSQIMRSLTPLINREEAFGEAGEAGLWPSITHTPDSQEEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA

人异型体4(短3)(耳畸蛋白)(SEQ ID NO:11)(也称为耳畸蛋白异型体b)(NCBI登录号NP_004793.2)

MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA

人异型体5(短4)(耳畸蛋白)(SEQ ID NO:12)(也称为耳畸蛋白异型体e)(NCBI登录号NP_001274418.1)

MALLIHLKTVSELRGRGDRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVASSIDRNEMLEIQVFNYSKVFSNKLIGTFRMVLQKVVEESHVEVTDTLIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGDFLGDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQRPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISSGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDKGFLPTLGPAWVNMYGSTRNYTLLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSNPELTSSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNEVDGLSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLLGA

完整cds(耳畸蛋白cDNA)(SEQ ID NO:13)(编码SEQ ID NO:8的蛋白质)

atga tcaaaacgga gaagtcctac cctgagcgtc gcctgcgggg cgtcctggaggagctgagct gtggctgctg ccgcttcctc tccctcgctg acaaggacca gggccactca tcccgcaccaggcttgaccg ggagcgcctc aagtcctgca tgagggagct ggaaaacatg gggcagcagg ccaggatgctgcgggcccag gtgaagcggc acacggtgcg ggacaagctg aggctgtgcc agaacttcct gcagaagctgcgcttcctgg cggacgagcc ccagcacagc attcccgaca tcttcatctg gatgatgagc aacaacaagcgtgtcgccta tgcccgtgtg ccctccaagg acctgctctt ctccatcgtg gaggaggaga ctggcaaggactgcgccaag gtcaagacgc tcttccttaa gctgccaggg aagcggggct tcggctcggc aggctggacagtgcaggcca aggtggagct gtacctgtgg ctgggcctca gcaaacagcg caaggagttc ctgtgcggcctgccctgtgg cttccaggag gtcaaggcag cccagggcct gggcctgcat gccttcccac ccgtcagcctggtctacacc aagaagcagg cgttccagct ccgagcgcac atgtaccagg cccgcagcct ctttgccgccgacagcagcg gactctcaga cccctttgcc cgcgtcttct tcatcaatca gagtcagtgc acagaggtgctgaatgagac cctgtgtccc acctgggacc agatgctggt gttcgacaac ctggagctct atggtgaagctcatgagctg agggacgatc cgcccatcat tgtcattgaa atctatgacc aggattccat gggcaaagctgacttcatgg gccggacctt cgccaaaccc ctggtgaaga tggcagacga ggcgtactgc ccaccccgcttcccacctca gctcgagtac taccagatct accgtggcaa cgccacagct ggagacccgc tggcggccttcgagctgctg cagattggac cagcagggaa ggctgacctg ccccccatca atggcccggt ggacgtggaccgaggtccca tcatgcccgt gcccatgggc atccggcccg tgctcagcaa gtaccgagtg gaggtgctgttctggggcct acgggaccta aagcgggtga acctggccca ggtggaccgg ccacgggtgg acatcgagtgtgcagggaag ggggtgcagt cgtccctgat ccacaattat aagaagaacc ccaacttcaa caccctcgtcaagtggtttg aagtggacct cccagagaac gagctgctgc acccgccctt gaacatccgt gtggtggactgccgggcctt cggtcgctac acactggtgg gctcccatgc cgtcagctcc ctgcgacgct tcatctaccggcccccagac cgctcggccc ccagctggaa caccacgggg gaggttgtgg tgactatgga gccagaggtacccatcaaga aactggagac catggtgaag ctggacgcga cttctgaagc tgttgtcaag gtggatgtggctgaggagga gaaggagaag aagaagaaga agaagggcac tgcggaggag ccagaggagg aggagccagacgagagcatg ctggactggt ggtccaagta ctttgcctcc attgacacca tgaaggagca acttcgacaacaagagccct ctggaattga cttggaggag aaggaggaag tggacaatac cgagggcctg aaggggtcaatgaagggcaa ggagaaggca agggctgcca aagaggagaa gaagaagaaa actcagagct ctggctctggccaggggtcc gaggcccccg agaagaagaa acccaagatt gatgagctta aggtataccc caaagagctggagtccgagt ttgataactt tgaggactgg ctgcacactt tcaacttgct tcggggcaag accggggatgatgaggatgg ctccaccgag gaggagcgca ttgtgggacg cttcaagggc tccctctgcg tgtacaaagtgccactccca gaggacgtgt cccgggaagc cggctacgac tccacctacg gcatgttcca gggcatcccgagcaatgacc ccatcaatgt gctggtccga gtctatgtgg tccgggccac ggacctgcac cctgctgacatcaacggcaa agctgacccc tacatcgcca tccggctagg caagactgac atccgcgaca aggagaactacatctccaag cagctcaacc ctgtctttgg gaagtccttt gacatcgagg cctccttccc catggaatccatgctgacgg tggctgtgta tgactgggac ctggtgggca ctgatgacct cattggggaa accaagatcgacctggagaa ccgcttctac agcaagcacc gcgccacctg cggcatcgcc cagacctact ccacacatggctacaatatc tggcgggacc ccatgaagcc cagccagatc ctgacccgcc tctgcaaaga cggcaaagtggacggccccc actttgggcc ccctgggaga gtgaaggtgg ccaaccgcgt cttcactggg ccctctgagattgaggacga gaacggtcag aggaagccca cagacgagca tgtggcgctg ttggccctga ggcactgggaggacatcccc cgcgcaggct gccgcctggt gccagagcat gtggagacga ggccgctgct caaccccgacaagccgggca tcgagcaggg ccgcctggag ctgtgggtgg acatgttccc catggacatg ccagcccctgggacgcctct ggacatctca cctcggaagc ccaagaagta cgagctgcgg gtcatcatct ggaacacagatgaggtggtc ttggaggacg acgacttctt cacaggggag aagtccagtg acatcttcgt gagggggtggctgaagggcc agcaggagga caagcaggac acagacgtcc actaccactc cctcactggc gagggcaacttcaactggcg ctacctgttc cccttcgact acctggcggc ggaggagaag atcgtcatct ccaagaaggagtccatgttc tcctgggacg agaccgagta caagatcccc gcgcggctca ccctgcagat ctgggatgcggaccacttct ccgctgacga cttcctgggg gccatcgagc tggacctgaa ccggttcccg cggggcgcaaagacagccaa gcagtgcacc atggagatgg ccaccgggga ggtggacgtg cccctcgtgt ccatcttcaagcaaaagcgc gtcaaaggct ggtggcccct cctggcccgc aatgagaacg atgagtttga gctcacgggcaaggtggagg ctgagctgca tttactgaca gcagaggagg cagagaagaa cccagtgggc ctggcccgcaatgaacctga ccccctagag aaacccaacc ggcccgacac gagcttcatc tggttcctga accctctcaagtcggctcgc tacttcttgt ggcacacgta tcgctggctg ctcctcaaac tgttgctgct cctgctgctgctcctcctcc tcgccctgtt cctctactct gtgcctggct acctggtcaa gaaaatcctc ggggcctga

人耳畸蛋白转录变体1(SEQ ID NO:14)(编码SEQ ID NO:8的蛋白质)

atggccttgctca tccacctcaa gacagtctcg gagctgcggg gcaggggcga ccggatcgccaaagtgactt tccgagggca atccttctac tctcgggtcc tggagaactg tgaggatgtg gctgactttgatgagacatt tcggtggccg gtggccagca gcatcgacag aaatgagatg ctggagattc aggttttcaactacagcaaa gtcttcagca acaagctcat cgggaccttc cgcatggtgc tgcagaaggt ggtagaggagagccatgtgg aggtgactga cacgctgatt gatgacaaca atgctatcat caagaccagc ctgtgcgtggaggtccggta tcaggccact gacggcacag tgggctcctg ggacgatggg gacttcctgg gagatgagtctcttcaagag gaagagaagg acagccaaga gacggatgga ctgctcccag gctcccggcc cagctcccggcccccaggag agaagagctt ccggagagcc gggaggagcg tgttctccgc catgaagctc ggcaaaaaccggtctcacaa ggaggagccc caaagaccag atgaaccggc ggtgctggag atggaagacc ttgaccatctggccattcgg ctaggagatg gactggatcc cgactcggtg tctctagcct cagtcacagc tctcaccactaatgtctcca acaagcgatc taagccagac attaagatgg agccaagtgc tgggcggccc atggattaccaggtcagcat cacggtgatc gaggcccggc agctggtggg cttgaacatg gaccctgtgg tgtgcgtggaggtgggtgac gacaagaagt acacatccat gaaggagtcc actaactgcc cctattacaa cgagtacttcgtcttcgact tccatgtctc tccggatgtc atgtttgaca agatcatcaa gatttcggtgattcactccaagaacctgct gcgcagtggc accctggtgg gctccttcaa aatggacgtg ggaaccgtgtactcgcagcc agagcaccag ttccatcaca agtgggccat cctgtctgac cccgatgaca tctcctcggggctgaagggc tacgtgaagt gtgacgttgc cgtggtgggc aaaggggaca acatcaagac gccccacaaggccaatgaga ccgacgaaga tgacattgag gggaacttgc tgctccccga gggggtgccc cccgaacgccagtgggcccg gttctatgtg aaaatttacc gagcagaggg gctgccccgt atgaacacaa gcctcatggccaatgtaaag aaggctttca tcggtgaaaa caaggacctc gtggacccct acgtgcaagt cttctttgctggccagaagg gcaagacttc agtgcagaag agcagctatg agcccctgtg gaatgagcag gtcgtctttacagacctctt ccccccactc tgcaaacgca tgaaggtgca gatccgagac tcggacaagg tcaacgacgtggccatcggc acccacttca ttgacctgcg caagatttct aatgacggag acaaaggctt cctgcccacactgggcccag cctgggtgaa catgtacggc tccacacgta actacacgct gctggatgag catcaggacctgaacgaggg cctgggggag ggtgtgtcct tccgggcccg gctcctgctg ggcctggctg tggagatcgtagacacctcc aaccctgagc tcaccagctc cacagaggtg caggtggagc aggccacgcc catctcggagagctgtgcag gtaaaatgga agaattcttt ctctttggag ccttcctgga ggcctcaatg atcgaccggagaaacggaga caagcccatc acctttgagg tcaccatagg caactatggg aacgaagttg atggcctgtcccggccccag cggcctcggc cccggaagga gccgggggat gaggaagaag tagacctgat tcagaacgcaagtgatgacg aggccggtga tgccggggac ctggcctcag tctcctccac tccaccaatg cggccccaggtcaccgacag gaactacttc catctgccct acctggagcg aaagccctgc atctacatca agagctggtggccggaccag cgccgccgcc tctacaatgc caacatcatg gaccacattg ccgacaagct ggaagaaggcctgaacgaca tacaggagat gatcaaaacg gagaagtcct accctgagcg tcgcctgcgg ggcgtcctggaggagctgag ctgtggctgc tgccgcttcc tctccctcgc tgacaaggac cagggccact catcccgcaccaggcttgac cgggagcgcc tcaagtcctg catgagggag ctggaaaaca tggggcagca ggccaggatgctgcgggccc aggtgaagcg gcacacggtg cgggacaagc tgaggctgtg ccagaacttc ctgcagaagctgcgcttcct ggcggacgag ccccagcaca gcattcccga catcttcatc tggatgatga gcaacaacaagcgtgtcgcc tatgcccgtg tgccctccaa ggacctgctc ttctccatcg tggaggagga gactggcaaggactgcgcca aggtcaagac gctcttcctt aagctgccag ggaagcgggg cttcggctcg gcaggctggacagtgcaggc caaggtggag ctgtacctgt ggctgggcct cagcaaacag cgcaaggagt tcctgtgcggcctgccctgt ggcttccagg aggtcaaggc agcccagggc ctgggcctgc atgccttccc acccgtcagcctggtctaca ccaagaagca ggcgttccag ctccgagcgc acatgtacca ggcccgcagc ctctttgccgccgacagcag cggactctca gacccctttg cccgcgtctt cttcatcaat cagagtcagt gcacagaggtgctgaatgag accctgtgtc ccacctggga ccagatgctg gtgttcgaca acctggagct ctatggtgaagctcatgagc tgagggacga tccgcccatc attgtcattg aaatctatga ccaggattcc atgggcaaagctgacttcat gggccggacc ttcgccaaac ccctggtgaa gatggcagac gaggcgtact gcccaccccgcttcccacct cagctcgagt actaccagat ctaccgtggc aacgccacag ctggagacct gctggcggccttcgagctgc tgcagattgg accagcaggg aaggctgacc tgccccccat caatggcccg gtggacgtggaccgaggtcc catcatgccc gtgcccatgg gcatccggcc cgtgctcagc aagtaccgag tggaggtgctgttctggggc ctacgggacc taaagcgggt gaacctggcc caggtggacc ggccacgggt ggacatcgagtgtgcaggga agggggtgca gtcgtccctg atccacaatt ataagaagaa ccccaacttc aacaccctcgtcaagtggtt tgaagtggac ctcccagaga acgagctgct gcacccgccc ttgaacatcc gtgtggtggactgccgggcc ttcggtcgct acacactggt gggctcccat gccgtcagct ccctgcgacg cttcatctaccggcccccag accgctcggc ccccagctgg aacaccacgg tcaggcttct ccggcgctgc cgtgtgctgtgcaatggggg ctcctcctct cactccacag gggaggttgt ggtgactatg gagccagagg tacccatcaagaaactggag accatggtga agctggacgc gacttctgaa gctgttgtca aggtggatgt ggctgaggaggagaaggaga agaagaagaa gaagaagggc actgcggagg agccagagga ggaggagcca gacgagagcatgctggactg gtggtccaag tactttgcct ccattgacac catgaaggag caacttcgac aacaagagccctctggaatt gacttggagg agaaggagga agtggacaat accgagggcc tgaaggggtc aatgaagggcaaggagaagg caagggctgc caaagaggag aagaagaaga aaactcagag ctctggctct ggccaggggtccgaggcccc cgagaagaag aaacccaaga ttgatgagct taaggtatac cccaaagagc tggagtccgagtttgataac tttgaggact ggctgcacac tttcaacttg cttcggggca agaccgggga tgatgaggatggctccaccg aggaggagcg cattgtggga cgcttcaagg gctccctctg cgtgtacaaa gtgccactcccagaggacgt gtcccgggaa gccggctacg actccaccta cggcatgttc cagggcatcc cgagcaatgaccccatcaat gtgctggtcc gagtctatgt ggtccgggcc acggacctgc accctgctga catcaacggcaaagctgacc cctacatcgc catccggcta ggcaagactg acatccgcga caaggagaac tacatctccaagcagctcaa ccctgtcttt gggaagtcct ttgacatcga ggcctccttc cccatggaat ccatgctgacggtggctgtg tatgactggg acctggtggg cactgatgac ctcattgggg aaaccaagat cgacctggagaaccgcttct acagcaagca ccgcgccacc tgcggcatcg cccagaccta ctccacacat ggctacaatatctggcggga ccccatgaag cccagccaga tcctgacccg cctctgcaaa gacggcaaag tggacggcccccactttggg ccccctggga gagtgaaggt ggccaaccgc gtcttcactg ggccctctga gattgaggacgagaacggtc agaggaagcc cacagacgag catgtggcgc tgttggccct gaggcactgg gaggacatcccccgcgcagg ctgccgcctg gtgccagagc atgtggagac gaggccgctg ctcaaccccg acaagccgggcatcgagcag ggccgcctgg agctgtgggt ggacatgttc cccatggaca tgccagcccc tgggacgcctctggacatct cacctcggaa gcccaagaag tacgagctgc gggtcatcat ctggaacaca gatgaggtggtcttggagga cgacgacttc ttcacagggg agaagtccag tgacatcttc gtgagggggt ggctgaagggccagcaggag gacaagcagg acacagacgt ccactaccac tccctcactg gcgagggcaa cttcaactggcgctacctgt tccccttcga ctacctggcg gcggaggaga agatcgtcat ctccaagaag gagtccatgttctcctggga cgagaccgag tacaagatcc ccgcgcggct caccctgcag atctgggatg cggaccacttctccgctgac gacttcctgg gggccatcga gctggacctg aaccggttcc cgcggggcgc aaagacagccaagcagtgca ccatggagat ggccaccggg gaggtggacg tgcccctcgt gtccatcttc aagcaaaagcgcgtcaaagg ctggtggccc ctcctggccc gcaatgagaa cgatgagttt gagctcacgg gcaaggtggaggctgagctg catttactga cagcagagga ggcagagaag aacccagtgg gcctggcccg caatgaacctgaccccctag agaaacccaa ccggcccgac acgagcttca tctggttcct gaaccctctc aagtcggctcgctacttctt gtggcacacg tatcgctggc tgctcctcaa actgttgctg ctcctgctgc tgctcctcctcctcgccctg ttcctctact ctgtgcctgg ctacctggtc aagaaaatcc tcggggcctg a

人耳畸蛋白转录变体2(SEQ ID NO:15)(编码SEQ ID NO:11的蛋白质)

atgatcaaaacgga gaagtcctac cctgagcgtc gcctgcgggg cgtcctggag gagctgagctgtggctgctg ccgcttcctc tccctcgctg acaaggacca gggccactca tcccgcacca ggcttgaccgggagcgcctc aagtcctgca tgagggagct ggaaaacatg gggcagcagg ccaggatgct gcgggcccaggtgaagcggc acacggtgcg ggacaagctg aggctgtgcc agaacttcct gcagaagctg cgcttcctggcggacgagcc ccagcacagc attcccgaca tcttcatctg gatgatgagc aacaacaagc gtgtcgcctatgcccgtgtg ccctccaagg acctgctctt ctccatcgtg gaggaggaga ctggcaagga ctgcgccaaggtcaagacgc tcttccttaa gctgccaggg aagcggggct tcggctcggc aggctggaca gtgcaggccaaggtggagct gtacctgtgg ctgggcctca gcaaacagcg caaggagttc ctgtgcggcc tgccctgtggcttccaggag gtcaaggcag cccagggcct gggcctgcat gccttcccac ccgtcagcct ggtctacaccaagaagcagg cgttccagct ccgagcgcac atgtaccagg cccgcagcct ctttgccgcc gacagcagcggactctcaga cccctttgcc cgcgtcttct tcatcaatca gagtcagtgc acagaggtgc tgaatgagaccctgtgtccc acctgggacc agatgctggt gttcgacaac ctggagctct atggtgaagc tcatgagctgagggacgatc cgcccatcat tgtcattgaa atctatgacc aggattccat gggcaaagct gacttcatgggccggacctt cgccaaaccc ctggtgaaga tggcagacga ggcgtactgc ccaccccgct tcccacctcagctcgagtac taccagatct accgtggcaa cgccacagct ggagacctgc tggcggcctt cgagctgctgcagattggac cagcagggaa ggctgacctg ccccccatca atggcccggt ggacgtggac cgaggtcccatcatgcccgt gcccatgggc atccggcccg tgctcagcaa gtaccgagtg gaggtgctgt tctggggcctacgggaccta aagcgggtga acctggccca ggtggaccgg ccacgggtgg acatcgagtg tgcagggaagggggtgcagt cgtccctgat ccacaattat aagaagaacc ccaacttcaa caccctcgtc aagtggtttgaagtggacct cccagagaac gagctgctgc acccgccctt gaacatccgt gtggtggact gccgggccttcggtcgctac acactggtgg gctcccatgc cgtcagctcc ctgcgacgct tcatctaccg gcccccagaccgctcggccc ccagctggaa caccacgggg gaggttgtgg tgactatgga gccagaggta cccatcaagaaactggagac catggtgaag ctggacgcga cttctgaagc tgttgtcaag gtggatgtgg ctgaggaggagaaggagaag aagaagaaga agaagggcac tgcggaggag ccagaggagg aggagccaga cgagagcatgctggactggt ggtccaagta ctttgcctcc attgacacca tgaaggagca acttcgacaa caagagccctctggaattga cttggaggag aaggaggaag tggacaatac cgagggcctg aaggggtcaa tgaagggcaaggagaaggca agggctgcca aagaggagaa gaagaagaaa actcagagct ctggctctgg ccaggggtccgaggcccccg agaagaagaa acccaagatt gatgagctta aggtataccc caaagagctg gagtccgagtttgataactt tgaggactgg ctgcacactt tcaacttgct tcggggcaag accggggatg atgaggatggctccaccgag gaggagcgca ttgtgggacg cttcaagggc tccctctgcg tgtacaaagt gccactcccagaggacgtgt cccgggaagc cggctacgac tccacctacg gcatgttcca gggcatcccg agcaatgaccccatcaatgt gctggtccga gtctatgtgg tccgggccac ggacctgcac cctgctgaca tcaacggcaaagctgacccc tacatcgcca tccggctagg caagactgac atccgcgaca aggagaacta catctccaagcagctcaacc ctgtctttgg gaagtccttt gacatcgagg cctccttccc catggaatcc atgctgacggtggctgtgta tgactgggac ctggtgggca ctgatgacct cattggggaa accaagatcg acctggagaaccgcttctac agcaagcacc gcgccacctg cggcatcgcc cagacctact ccacacatgg ctacaatatctggcgggacc ccatgaagcc cagccagatc ctgacccgcc tctgcaaaga cggcaaagtg gacggcccccactttgggcc ccctgggaga gtgaaggtgg ccaaccgcgt cttcactggg ccctctgaga ttgaggacgagaacggtcag aggaagccca cagacgagca tgtggcgctg ttggccctga ggcactggga ggacatcccccgcgcaggct gccgcctggt gccagagcat gtggagacga ggccgctgct caaccccgac aagccgggcatcgagcaggg ccgcctggag ctgtgggtgg acatgttccc catggacatg ccagcccctg ggacgcctctggacatctca cctcggaagc ccaagaagta cgagctgcgg gtcatcatct ggaacacaga tgaggtggtcttggaggacg acgacttctt cacaggggag aagtccagtg acatcttcgt gagggggtgg ctgaagggccagcaggagga caagcaggac acagacgtcc actaccactc cctcactggc gagggcaact tcaactggcgctacctgttc cccttcgact acctggcggc ggaggagaag atcgtcatct ccaagaagga gtccatgttctcctgggacg agaccgagta caagatcccc gcgcggctca ccctgcagat ctgggatgcg gaccacttctccgctgacga cttcctgggg gccatcgagc tggacctgaa ccggttcccg cggggcgcaa agacagccaagcagtgcacc atggagatgg ccaccgggga ggtggacgtg cccctcgtgt ccatcttcaa gcaaaagcgcgtcaaaggct ggtggcccct cctggcccgc aatgagaacg atgagtttga gctcacgggc aaggtggaggctgagctgca tttactgaca gcagaggagg cagagaagaa cccagtgggc ctggcccgca atgaacctgaccccctagag aaacccaacc ggcccgacac gagcttcatc tggttcctga accctctcaa gtcggctcgctacttcttgt ggcacacgta tcgctggctg ctcctcaaac tgttgctgct cctgctgctg ctcctcctcctcgccctgtt cctctactct gtgcctggct acctggtcaa gaaaatcctc ggggcctga

人耳畸蛋白转录变体3(SEQ ID NO:16)(编码SEQ ID NO:8的蛋白质)

atgatgaccga tactcaggat ggccctagcg agagctccca gatcatgagg tccctcactcccctgatcaa cagggaggag gcatttgggg aggctgggga ggcggggctg tggcccagca tcacccacactcctgattca caggaagaag gcctgaacga catacaggag atgatcaaaa cggagaagtc ctaccctgagcgtcgcctgc ggggcgtcct ggaggagctg agctgtggct gctgccgctt cctctccctc gctgacaaggaccagggcca ctcatcccgc accaggcttg accgggagcg cctcaagtcc tgcatgaggg agctggaaaacatggggcag caggccagga tgctgcgggc ccaggtgaag cggcacacgg tgcgggacaa gctgaggctgtgccagaact tcctgcagaa gctgcgcttc ctggcggacg agccccagca cagcattccc gacatcttcatctggatgat gagcaacaac aagcgtgtcg cctatgcccg tgtgccctcc aaggacctgc tcttctccatcgtggaggag gagactggca aggactgcgc caaggtcaag acgctcttcc ttaagctgcc agggaagcggggcttcggct cggcaggctg gacagtgcag gccaaggtgg agctgtacct gtggctgggc ctcagcaaacagcgcaagga gttcctgtgc ggcctgccct gtggcttcca ggaggtcaag gcagcccagg gcctgggcctgcatgccttc ccacccgtca gcctggtcta caccaagaag caggcgttcc agctccgagc gcacatgtaccaggcccgca gcctctttgc cgccgacagc agcggactct cagacccctt tgcccgcgtc ttcttcatcaatcagagtca gtgcacagag gtgctgaatg agaccctgtg tcccacctgg gaccagatgc tggtgttcgacaacctggag ctctatggtg aagctcatga gctgagggac gatccgccca tcattgtcat tgaaatctatgaccaggatt ccatgggcaa agctgacttc atgggccgga ccttcgccaa acccctggtg aagatggcagacgaggcgta ctgcccaccc cgcttcccac ctcagctcga gtactaccag atctaccgtg gcaacgccacagctggagac ctgctggcgg ccttcgagct gctgcagatt ggaccagcag ggaaggctga cctgccccccatcaatggcc cggtggacgt ggaccgaggt cccatcatgc ccgtgcccat gggcatccgg cccgtgctcagcaagtaccg agtggaggtg ctgttctggg gcctacggga cctaaagcgg gtgaacctgg cccaggtggaccggccacgg gtggacatcg agtgtgcagg gaagggggtg cagtcgtccc tgatccacaa ttataagaagaaccccaact tcaacaccct cgtcaagtgg tttgaagtgg acctcccaga gaacgagctg ctgcacccgcccttgaacat ccgtgtggtg gactgccggg ccttcggtcg ctacacactg gtgggctccc atgccgtcagctccctgcga cgcttcatct accggccccc agaccgctcg gcccccagct ggaacaccac ggtcaggcttctccggcgct gccgtgtgct gtgcaatggg ggctcctcct ctcactccac aggggaggtt gtggtgactatggagccaga ggtacccatc aagaaactgg agaccatggt gaagctggac gcgacttctg aagctgttgtcaaggtggat gtggctgagg aggagaagga gaagaagaag aagaagaagg gcactgcgga ggagccagaggaggaggagc cagacgagag catgctggac tggtggtcca agtactttgc ctccattgac accatgaaggagcaacttcg acaacaagag ccctctggaa ttgacttgga ggagaaggag gaagtggaca ataccgagggcctgaagggg tcaatgaagg gcaaggagaa ggcaagggct gccaaagagg agaagaagaa gaaaactcagagctctggct ctggccaggg gtccgaggcc cccgagaaga agaaacccaa gattgatgag cttaaggtataccccaaaga gctggagtcc gagtttgata actttgagga ctggctgcac actttcaact tgcttcggggcaagaccggg gatgatgagg atggctccac cgaggaggag cgcattgtgg gacgcttcaa gggctccctctgcgtgtaca aagtgccact cccagaggac gtgtcccggg aagccggcta cgactccacc tacggcatgttccagggcat cccgagcaat gaccccatca atgtgctggt ccgagtctat gtggtccggg ccacggacctgcaccctgct gacatcaacg gcaaagctga cccctacatc gccatccggc taggcaagac tgacatccgcgacaaggaga actacatctc caagcagctc aaccctgtct ttgggaagtc ctttgacatc gaggcctccttccccatgga atccatgctg acggtggctg tgtatgactg ggacctggtg ggcactgatg acctcattggggaaaccaag atcgacctgg agaaccgctt ctacagcaag caccgcgcca cctgcggcat cgcccagacctactccacac atggctacaa tatctggcgg gaccccatga agcccagcca gatcctgacc cgcctctgcaaagacggcaa agtggacggc ccccactttg ggccccctgg gagagtgaag gtggccaacc gcgtcttcactgggccctct gagattgagg acgagaacgg tcagaggaag cccacagacg agcatgtggc gctgttggccctgaggcact gggaggacat cccccgcgca ggctgccgcc tggtgccaga gcatgtggag acgaggccgctgctcaaccc cgacaagccg ggcatcgagc agggccgcct ggagctgtgg gtggacatgt tccccatggacatgccagcc cctgggacgc ctctggacat ctcacctcgg aagcccaaga agtacgagct gcgggtcatcatctggaaca cagatgaggt ggtcttggag gacgacgact tcttcacagg ggagaagtcc agtgacatcttcgtgagggg gtggctgaag ggccagcagg aggacaagca ggacacagac gtccactacc actccctcactggcgagggc aacttcaact ggcgctacct gttccccttc gactacctgg cggcggagga gaagatcgtcatctccaaga aggagtccat gttctcctgg gacgagaccg agtacaagat ccccgcgcgg ctcaccctgcagatctggga tgcggaccac ttctccgctg acgacttcct gggggccatc gagctggacc tgaaccggttcccgcggggc gcaaagacag ccaagcagtg caccatggag atggccaccg gggaggtgga cgtgcccctcgtgtccatct tcaagcaaaa gcgcgtcaaa ggctggtggc ccctcctggc ccgcaatgag aacgatgagtttgagctcac gggcaaggtg gaggctgagc tgcatttact gacagcagag gaggcagaga agaacccagtgggcctggcc cgcaatgaac ctgaccccct agagaaaccc aaccggcccg acacgagctt catctggttcctgaaccctc tcaagtcggc tcgctacttc ttgtggcaca cgtatcgctg gctgctcctc aaactgttgctgctcctgct gctgctcctc ctcctcgccc tgttcctcta ctctgtgcct ggctacctgg tcaagaaaatcctcggggcc tga

人耳畸蛋白转录变体4(SEQ ID NO:17)(编码SEQ ID NO:9的蛋白质)

atga tcaaaacgga gaagtcctac cctgagcgtc gcctgcgggg cgtcctggaggagctgagct gtggctgctg ccgcttcctc tccctcgctg acaaggacca gggccactca tcccgcaccaggcttgaccg ggagcgcctc aagtcctgca tgagggagct ggaaaacatg gggcagcagg ccaggatgctgcgggcccag gtgaagcggc acacggtgcg ggacaagctg aggctgtgcc agaacttcct gcagaagctgcgcttcctgg cggacgagcc ccagcacagc attcccgaca tcttcatctg gatgatgagc aacaacaagcgtgtcgccta tgcccgtgtg ccctccaagg acctgctctt ctccatcgtg gaggaggaga ctggcaaggactgcgccaag gtcaagacgc tcttccttaa gctgccaggg aagcggggct tcggctcggc aggctggacagtgcaggcca aggtggagct gtacctgtgg ctgggcctca gcaaacagcg caaggagttc ctgtgcggcctgccctgtgg cttccaggag gtcaaggcag cccagggcct gggcctgcat gccttcccac ccgtcagcctggtctacacc aagaagcagg cgttccagct ccgagcgcac atgtaccagg cccgcagcct ctttgccgccgacagcagcg gactctcaga cccctttgcc cgcgtcttct tcatcaatca gagtcagtgc acagaggtgctgaatgagac cctgtgtccc acctgggacc agatgctggt gttcgacaac ctggagctct atggtgaagctcatgagctg agggacgatc cgcccatcat tgtcattgaa atctatgacc aggattccat gggcaaagctgacttcatgg gccggacctt cgccaaaccc ctggtgaaga tggcagacga ggcgtactgc ccaccccgcttcccacctca gctcgagtac taccagatct accgtggcaa cgccacagct ggagacctgc tggcggccttcgagctgctg cagattggac cagcagggaa ggctgacctg ccccccatca atggcccggt ggacgtggaccgaggtccca tcatgcccgt gcccatgggc atccggcccg tgctcagcaa gtaccgagtg gaggtgctgttctggggcct acgggaccta aagcgggtga acctggccca ggtggaccgg ccacgggtgg acatcgagtgtgcagggaag ggggtgcagt cgtccctgat ccacaattat aagaagaacc ccaacttcaa caccctcgtcaagtggtttgaagtggacct cccagagaac gagctgctgc acccgccctt gaacatccgt gtggtggactgccgggcctt cggtcgctac acactggtgg gctcccatgc cgtcagctcc ctgcgacgct tcatctaccggcccccagac cgctcggccc ccagctggaa caccacgggg gaggttgtgg tgactatgga gccagaggtacccatcaaga aactggagac catggtgaag ctggacgcga cttctgaagc tgttgtcaag gtggatgtggctgaggagga gaaggagaag aagaagaaga agaagggcac tgcggaggag ccagaggagg aggagccagacgagagcatg ctggactggt ggtccaagta ctttgcctcc attgacacca tgaaggagca acttcgacaacaagagccct ctggaattga cttggaggag aaggaggaag tggacaatac cgagggcctg aaggggtcaatgaagggcaa ggagaaggca agggctgcca aagaggagaa gaagaagaaa actcagagct ctggctctggccaggggtcc gaggcccccg agaagaagaa acccaagatt gatgagctta aggtataccc caaagagctggagtccgagt ttgataactt tgaggactgg ctgcacactt tcaacttgct tcggggcaag accggggatgatgaggatgg ctccaccgag gaggagcgca ttgtgggacg cttcaagggc tccctctgcg tgtacaaagtgccactccca gaggacgtgt cccgggaagc cggctacgac tccacctacg gcatgttcca gggcatcccgagcaatgacc ccatcaatgt gctggtccga gtctatgtgg tccgggccac ggacctgcac cctgctgacatcaacggcaa agctgacccc tacatcgcca tccggctagg caagactgac atccgcgaca aggagaactacatctccaag cagctcaacc ctgtctttgg gaagtccttt gacatcgagg cctccttccc catggaatccatgctgacgg tggctgtgta tgactgggac ctggtgggca ctgatgacct cattggggaa accaagatcgacctggagaa ccgcttctac agcaagcacc gcgccacctg cggcatcgcc cagacctact ccacacatggctacaatatc tggcgggacc ccatgaagcc cagccagatc ctgacccgcc tctgcaaaga cggcaaagtggacggccccc actttgggcc ccctgggaga gtgaaggtgg ccaaccgcgt cttcactggg ccctctgagattgaggacga gaacggtcag aggaagccca cagacgagca tgtggcgctg ttggccctga ggcactgggaggacatcccc cgcgcaggct gccgcctggt gccagagcat gtggagacga ggccgctgct caaccccgacaagccgggca tcgagcaggg ccgcctggag ctgtgggtgg acatgttccc catggacatg ccagcccctgggacgcctct ggacatctca cctcggaagc ccaagaagta cgagctgcgg gtcatcatct ggaacacagatgaggtggtc ttggaggacg acgacttctt cacaggggag aagtccagtg acatcttcgt gagggggtggctgaagggcc agcaggagga caagcaggac acagacgtcc actaccactc cctcactggc gagggcaacttcaactggcg ctacctgttc cccttcgact acctggcggc ggaggagaag atcgtcatct ccaagaaggacctggcccgc aatgagaacg atgagtttga gctcacgggc aaggtggagg ctgagctgca tttactgacagcagaggagg cagagaagaa cccagtgggc ctggcccgca atgaacctga ccccctagag aaacccaaccggcccgacac ggccttcgtc tggttcctca accctctcaa gtccatcaag tacctcatct gcacccggtacaagtggctc atcatcaaga tcgtgctggc gctgttgggg ctgctcatgt tggggctctt cctctacagcctccctggct acatggtcaa aaagctcctt ggggcatga

人耳畸蛋白转录变体5(SEQ ID NO:18)(编码SEQ ID NO:12的蛋白质)

atg gccttgctca tccacctcaa gacagtctcg gagctgcggg gcaggggcga ccggatcgccaaagtgactt tccgagggca atccttctac tctcgggtcc tggagaactg tgaggatgtg gctgactttgatgagacatt tcggtggccg gtggccagca gcatcgacag aaatgagatg ctggagattc aggttttcaactacagcaaa gtcttcagca acaagctcat cgggaccttc cgcatggtgc tgcagaaggt ggtagaggagagccatgtgg aggtgactga cacgctgatt gatgacaaca atgctatcat caagaccagc ctgtgcgtggaggtccggta tcaggccact gacggcacag tgggctcctg ggacgatggg gacttcctgg gagatgagtctcttcaagag gaagagaagg acagccaaga gacggatgga ctgctcccag gctcccggcc cagctcccggcccccaggag agaagagctt ccggagagcc gggaggagcg tgttctccgc catgaagctc ggcaaaaaccggtctcacaa ggaggagccc caaagaccag atgaaccggc ggtgctggag atggaagacc ttgaccatctggccattcgg ctaggagatg gactggatcc cgactcggtg tctctagcct cagtcacagc tctcaccactaatgtctcca acaagcgatc taagccagac attaagatgg agccaagtgc tgggcggccc atggattaccaggtcagcat cacggtgatc gaggcccggc agctggtggg cttgaacatg gaccctgtgg tgtgcgtggaggtgggtgac gacaagaagt acacatccat gaaggagtcc actaactgcc cctattacaa cgagtacttcgtcttcgact tccatgtctc tccggatgtc atgtttgaca agatcatcaa gatttcggtg attcactccaagaacctgct gcgcagtggc accctggtgg gctccttcaa aatggacgtg ggaaccgtgt actcgcagccagagcaccag ttccatcaca agtgggccat cctgtctgac cccgatgaca tctcctcggg gctgaagggctacgtgaagt gtgacgttgc cgtggtgggc aaaggggaca acatcaagac gccccacaag gccaatgagaccgacgaaga tgacattgag gggaacttgc tgctccccga gggggtgccc cccgaacgcc agtgggcccggttctatgtg aaaatttacc gagcagaggg gctgccccgt atgaacacaa gcctcatggc caatgtaaagaaggctttca tcggtgaaaa caaggacctc gtggacccct acgtgcaagt cttctttgct ggccagaagggcaagacttc agtgcagaag agcagctatg agcccctgtg gaatgagcag gtcgtcttta cagacctcttccccccactc tgcaaacgca tgaaggtgca gatccgagac tcggacaagg tcaacgacgt ggccatcggcacccacttca ttgacctgcg caagatttct aatgacggag acaaaggctt cctgcccaca ctgggcccagcctgggtgaa catgtacggc tccacacgta actacacgct gctggatgag catcaggacc tgaacgagggcctgggggag ggtgtgtcct tccgggcccg gctcctgctg ggcctggctg tggagatcgt agacacctccaaccctgagc tcaccagctc cacagaggtg caggtggagc aggccacgcc catctcggag agctgtgcaggtaaaatgga agaattcttt ctctttggag ccttcctgga ggcctcaatg atcgaccgga gaaacggagacaagcccatc acctttgagg tcaccatagg caactatggg aacgaagttg atggcctgtc ccggccccagcggcctcggc cccggaagga gccgggggat gaggaagaag tagacctgat tcagaacgca agtgatgacgaggccggtga tgccggggac ctggcctcag tctcctccac tccaccaatg cggccccagg tcaccgacaggaactacttc catctgccct acctggagcg aaagccctgc atctacatca agagctggtg gccggaccagcgccgccgcc tctacaatgc caacatcatg gaccacattg ccgacaagct ggaagaaggc ctgaacgacatacaggagat gatcaaaacg gagaagtcct accctgagcg tcgcctgcgg ggcgtcctgg aggagctgagctgtggctgc tgccgcttcc tctccctcgc tgacaaggac cagggccact catcccgcac caggcttgaccgggagcgcc tcaagtcctg catgagggag ctggaaaaca tggggcagca ggccaggatg ctgcgggcccaggtgaagcg gcacacggtg cgggacaagc tgaggctgtg ccagaacttc ctgcagaagc tgcgcttcctggcggacgag ccccagcaca gcattcccga catcttcatc tggatgatga gcaacaacaa gcgtgtcgcctatgcccgtg tgccctccaa ggacctgctc ttctccatcg tggaggagga gactggcaag gactgcgccaaggtcaagac gctcttcctt aagctgccag ggaagcgggg cttcggctcg gcaggctgga cagtgcaggccaaggtggag ctgtacctgt ggctgggcct cagcaaacag cgcaaggagt tcctgtgcgg cctgccctgtggcttccagg aggtcaaggc agcccagggc ctgggcctgc atgccttccc acccgtcagc ctggtctacaccaagaagca ggcgttccag ctccgagcgc acatgtacca ggcccgcagc ctctttgccg ccgacagcagcggactctca gacccctttg cccgcgtctt cttcatcaat cagagtcagt gcacagaggt gctgaatgagaccctgtgtc ccacctggga ccagatgctg gtgttcgaca acctggagct ctatggtgaa gctcatgagctgagggacga tccgcccatc attgtcattg aaatctatga ccaggattcc atgggcaaag ctgacttcatgggccggacc ttcgccaaac ccctggtgaa gatggcagac gaggcgtact gcccaccccg cttcccacctcagctcgagt actaccagat ctaccgtggc aacgccacag ctggagacct gctggcggcc ttcgagctgctgcagattgg accagcaggg aaggctgacc tgccccccat caatggcccg gtggacgtgg accgaggtcccatcatgccc gtgcccatgg gcatccggcc cgtgctcagc aagtaccgag tggaggtgct gttctggggcctacgggacc taaagcgggt gaacctggcc caggtggacc ggccacgggt ggacatcgag tgtgcagggaagggggtgca gtcgtccctg atccacaatt ataagaagaa ccccaacttc aacaccctcg tcaagtggtttgaagtggac ctcccagaga acgagctgct gcacccgccc ttgaacatcc gtgtggtgga ctgccgggccttcggtcgct acacactggt gggctcccat gccgtcagct ccctgcgacg cttcatctac cggcccccagaccgctcggc ccccagctgg aacaccacgg tcaggcttct ccggcgctgc cgtgtgctgt gcaatgggggctcctcctct cactccacag gggaggttgt ggtgactatg gagccagagg tacccatcaa gaaactggagaccatggtga agctggacgc gacttctgaa gctgttgtca aggtggatgt ggctgaggag gagaaggagaagaagaagaa gaagaagggc actgcggagg agccagagga ggaggagcca gacgagagca tgctggactggtggtccaag tactttgcct ccattgacac catgaaggag caacttcgac aacaagagcc ctctggaattgacttggagg agaaggagga agtggacaat accgagggcc tgaaggggtc aatgaagggc aaggagaaggcaagggctgc caaagaggag aagaagaaga aaactcagag ctctggctct ggccaggggt ccgaggcccccgagaagaag aaacccaaga ttgatgagct taaggtatac cccaaagagc tggagtccga gtttgataactttgaggact ggctgcacac tttcaacttg cttcggggca agaccgggga tgatgaggat ggctccaccgaggaggagcg cattgtggga cgcttcaagg gctccctctg cgtgtacaaa gtgccactcc cagaggacgtgtcccgggaa gccggctacg actccaccta cggcatgttc cagggcatcc cgagcaatga ccccatcaatgtgctggtcc gagtctatgt ggtccgggcc acggacctgc accctgctga catcaacggc aaagctgacccctacatcgc catccggcta ggcaagactg acatccgcga caaggagaac tacatctcca agcagctcaaccctgtcttt gggaagtcct ttgacatcga ggcctccttc cccatggaat ccatgctgac ggtggctgtgtatgactggg acctggtggg cactgatgac ctcattgggg aaaccaagat cgacctggag aaccgcttctacagcaagca ccgcgccacc tgcggcatcg cccagaccta ctccacacat ggctacaata tctggcgggaccccatgaag cccagccaga tcctgacccg cctctgcaaa gacggcaaag tggacggccc ccactttgggccccctggga gagtgaaggt ggccaaccgc gtcttcactg ggccctctga gattgaggac gagaacggtcagaggaagcc cacagacgag catgtggcgc tgttggccct gaggcactgg gaggacatcc cccgcgcaggctgccgcctg gtgccagagc atgtggagac gaggccgctg ctcaaccccg acaagccggg catcgagcagggccgcctgg agctgtgggt ggacatgttc cccatggaca tgccagcccc tgggacgcct ctggacatctcacctcggaa gcccaagaag tacgagctgc gggtcatcat ctggaacaca gatgaggtgg tcttggaggacgacgacttc ttcacagggg agaagtccag tgacatcttc gtgagggggt ggctgaaggg ccagcaggaggacaagcagg acacagacgt ccactaccac tccctcactg gcgagggcaa cttcaactgg cgctacctgttccccttcga ctacctggcg gcggaggaga agatcgtcat ctccaagaag gagtccatgt tctcctgggacgagaccgag tacaagatcc ccgcgcggct caccctgcag atctgggatg cggaccactt ctccgctgacgacttcctgg gggccatcga gctggacctg aaccggttcc cgcggggcgc aaagacagcc aagcagtgcaccatggagat ggccaccggg gaggtggacg tgcccctcgt gtccatcttc aagcaaaagc gcgtcaaaggctggtggccc ctcctggccc gcaatgagaa cgatgagttt gagctcacgg gcaaggtgga ggctgagctgcatttactga cagcagagga ggcagagaag aacccagtgg gcctggcccg caatgaacct gaccccctagagaaacccaa ccggcccgac acggccttcg tctggttcct caaccctctc aagtccatca agtacctcatctgcacccgg tacaagtggc tcatcatcaa gatcgtgctg gcgctgttgg ggctgctcat gttggggctcttcctctaca gcctccctgg ctacatggtc aaaaagctcc ttggggcatg a

人野生型硬纤毛蛋白基因组DNA序列的非限制性实例是SEQ ID NO:19。SEQ IDNO:19中的外显子是：核苷酸位置5001-5206(外显子1)、核苷酸位置25925-25983(外显子2)、核苷酸位置35779-35867(外显子3)、核苷酸位置44590-44689(外显子4)、核苷酸位置47100-47281(外显子5)、核苷酸位置59854-59927(外显子6)、核苷酸位置61273-61399(外显子7)、核苷酸位置61891-61945(外显子8)、核苷酸位置68626-68757(外显子9)、核苷酸位置73959-74021(外显子10)、核苷酸位置74404-74488(外显子11)、核苷酸位置79066-79225(外显子12)、核苷酸位置80051-80237(外显子13)、核苷酸位置81107-81293(外显子14)、核苷酸位置82690-82913(外显子15)、核苷酸位置83388-83496(外显子16)、核苷酸位置84046-84226(外显子17)、核苷酸位置84315-84435(外显子18)、核苷酸位置85950-86050(外显子19)、核苷酸位置86193-86283(外显子20)、核苷酸位置86411-86527(外显子21)、核苷酸位置86656-86808(外显子22)、核苷酸位置87382-87571(外显子23)、核苷酸位置87661-87785(外显子24)、核苷酸位置88206-88340(外显子25)、核苷酸位置89025-89186(外显子26)、核苷酸位置89589-89708(外显子27)、核苷酸位置90132-90293(外显子28)、核苷酸位置90405-90567(外显子29)、核苷酸位置91050-91180(外显子30)、核苷酸位置92549-92578(外显子31)、核苷酸位置92978-93106(外显子32)、核苷酸位置95225-95291(外显子33)、核苷酸位置96198-96334(外显子34)、核苷酸位置96466-96600(外显子35)、核苷酸位置96848-96985(外显子36)、核苷酸位置97623-97750(外显子37)、核苷酸位置97857-98027(外显子38)、核苷酸位置98670-98830(外显子39)、核苷酸位置99593-99735(外显子40)、核苷酸位置100128-100216(外显子41)、核苷酸位置101518-101616(外显子42)、核苷酸位置101762-102003(外显子43)、核苷酸位置102669-102847(外显子44)、核苷酸位置102952-103052(外显子45)、核苷酸位置103494-103691(外显子46)、核苷酸位置105479-106496(外显子47)和外显子48(以CCGGCCCGAC起始的序列(SEQ ID NO:89)；另请参见Yasunaga等人，Am.J.Hum.Genet.67:591-600,2000中对该外显子的描述)。

内含子位于SEQ ID NO:19中每个相邻的外显子对之间，即，处于核苷酸位置100-5001(内含子1)、核苷酸5207-25924(内含子2)、核苷酸位置25984-35778(内含子3)、核苷酸位置35868-44589(内含子4)、核苷酸位置44690-47099(内含子5)、核苷酸位置47282-59853(内含子6)、核苷酸位置59928-61272(内含子7)、核苷酸位置61400-61890(内含子8)、核苷酸位置61946-68625(内含子9)、核苷酸位置68758-73958(内含子10)、核苷酸位置74022-74403(内含子11)、核苷酸位置74489-79065(内含子12)、核苷酸位置79226-80050(内含子13)、核苷酸位置80238-81106(内含子14)、核苷酸位置81294-82689(内含子15)、核苷酸位置82914-83387(内含子16)、核苷酸位置83497-84045(内含子17)、核苷酸位置84227-84314(内含子18)、核苷酸位置84436-85949(内含子19)、核苷酸位置86051-86192(内含子20)、核苷酸位置86284-86410(内含子21)、核苷酸位置86528-86655(内含子22)、核苷酸位置86809-87381(内含子23)、核苷酸位置87572-87660(内含子24)、核苷酸位置87786-88205(内含子25)、核苷酸位置88341-89024(内含子26)、核苷酸位置89187-89588(内含子27)、核苷酸位置89709-90131(内含子28)、核苷酸位置90294-90404(内含子29)、核苷酸位置90568-91049(内含子30)、核苷酸位置91181-92548(内含子31)、核苷酸位置92579-92977(内含子32)、核苷酸位置93107-95224(内含子33)、核苷酸位置95292-96197(内含子34)、核苷酸位置96335-96465(内含子35)、核苷酸位置96601-96847(内含子36)、核苷酸位置96986-97622(内含子37)、核苷酸位置97751-97856(内含子38)、核苷酸位置98028-98669(内含子39)、核苷酸位置98831-99592(内含子40)、核苷酸位置99736-100127(内含子41)、核苷酸位置100217-101517(内含子42)、核苷酸位置101617-101761(内含子43)、核苷酸位置102004-102668(内含子44)、核苷酸位置102848-102951(内含子45)、核苷酸位置103053-103494(内含子46)、核苷酸位置103692-105478(内含子47)和核苷酸位置106497-108496(内含子48)。

人耳畸蛋白基因序列(SEQ ID NO:19)(NCBI登录号NG_009937.1)

1 gggagagcat gcgggctttt tcacccattt ggagactctg cctgcagaat cctcaagaca

61 ttcatttcat tcattcgttc actctttttt tcagacaagg gttcttagga tcattcattc

121 attctataca gatttgctga tactgtacag gttgcctctc agaatccagt gcctgttctc

181 agtacctatg ctgactggta ggagggataa agacagcctt acaccctggg agaggcggtc

241 cagagtagaa acatcagaca ctgtaggaga aagagccaaa gaacaggagg caacagccag

301 acttgcatgt tagatggttg gagtctgaaa atatccagag taaagaaagg taggtgtaac

361 ctagtatttg aaagtgctaa acagcaagcc agcgctcagg gcaagtggcc aggaagcttt

421 ccaagaaaaa cttctgggag gataaaggga ggtctgtgaa aggaccgacc gcaaagtcgg

481 gcgggtactg cacacatgac ccattaacta cggctcttcc ggccttgcca ggttcttcga

541 gcgggcaccc acccggtatc cttccctcct tcaaccaaca agtactgacc ttgcccgaat

601 gctgggtgct ggccctgtgc gccggacgga agggcctgat tttctcgcat tttctctaag

661 cgctggaggc tgcccgcctg gggcgtctcc aagcactaaa ccccacgtgg ctccatctcc

721 tcccccttcc ccggctacat ccatgcgagg tcccttatgc cctgctggct gtgccccact

781 tgccagggag cgccttcctg tgaaggggaa tctggggagg cccccgcccg tgcctgccca

841 cttcctactc tgaaaccaca aacctctagg aaggcccctc gccccgtcgg gtggaaaatt

901 ggctcctcgg ggttccttca accccaaagt ccgggggcag ggggctgaat ttcgatcacc

961 gaggagggcg ctagtggaag ggggagggga ggaggcgctc cctcggcctt acccgggcat

1021 gagtccaggg ggcacgtagg cggcattgaa ctcggtcagt agggtgcccgcgctgcggga

1081 ggccatggtg ggtgcgcgag tacagcgagc ctggcgctcc gctccgccccacggtaaaca

1141 gcggcgggtc acctggcaac ggccacggcg gcgagcctgg caacgccagctggccccgcg

1201 gtcctcgcgt tccgagacac tgcgcccccc tggcggccac ctcccggagcagccccatag

1261 ggcgcgccca gaaggcgcct cccatttccg cgagctctgc tgggtgacccctgtcacttg

1321 ccccggcgcg tcggggctct ctgccttgct gcctgcggga tgtgcagaggctcagatgcg

1381 ggagggaggc agaacatcgc tggagaggcc tggcgggatc cgtcttgcggtgacccggct

1441 tggaacgcga cgctaccaca aaggacaggc caggtcctga ctttggaggtcacgcacgaa

1501 gcagctgccc caccgtggct caggcccaga aacctgagtg gccttagggtccccaggagc

1561 tatgtctctc caaggcttcc cctgcacccc agctccatgg gagttccaggaaggggctct

1621 gtagtgggcc gcgctgggcg aggttgccta ggacgctgtg tgtaattgtgtgtgtgcgtg

1681 cgtgcgtgca tgtgtgcgtg tgtgtgtgcg cgccttgcga agaggagcatttttcatttt

1741 tcttcttaat ctctagctga tggcttcctt ctcacctcat catacctgtaaactactcca

1801 caagaggcaa aaagaaaatc atagaacgtc tgggtgtgtg atttacatttgtccccaatg

1861 ctgccgttca ttttggggat ggcatccgca ggggtagcgc ttgccccagagagcaggcct

1921 gctgaaggcc caccccctgt gtaatcctcc ctgtgactgc ttcagcctccacatttgagt

1981 ttctccaggg acccttacac cagccttggt gcctagggca ggcacagggccttcggcttt

2041 tccataaggg gtgagggtat ggggacagct tccacggtgc caggctcttggtgactcggg

2101 tggaggccct gccaccccag ctccctctgc agcagtcctg gtgtcatgaagaagcctggc

2161 agttcccact ttgtctccag gtcttgcttc ttcccttcag atgccggatggagagcagtg

2221 ctcccctcgc acttcggttc tgtaaatggc agtggatgaa gaccgcagacgctactgggt

2281 tcacagaatg tggctgccac cagcattctc caaagacttc ccctggcaaatgccaatgaa

2341 atgaagggga gccacaggct tcccagaggc tcaggaagca gaaacactgaggcctggttg

2401 gaaagagagc tgtaggcaaa ggaacggctg caaacaaact gggtggaaggaaaatccatc

2461 catccttcag aatgcagtca tgtctgtatt tttctaaatt ctcattggggaacatgttct

2521 acaataagga aaacatgagt caaagacccc cagccctggt gaggttgaccgcctacttcc

2581 tcccccattc agggctgccc agccagtcct gctggtaaac ccaccaccctgccttccacc

2641 tgcctgtgtt ctagtccatc tgtctcgtct gattgggatc ctgtgccatccatatcatat

2701 tcatccctga atctcagcac ctggctctgg aaagaattca gtaaatgttcattacataaa

2761 ttatatactc agttaccaaa atgggtaaca gaagaatgga aattaaaaagtgggttctgg

2821 ctgggaacgg tggctcatgc ctgtaatccc agcattttgg aaggccgaggcaggcggatc

2881 acttgaggtc agcagtttga gaccagccta gccaacatgg tgaaaccccatctctactaa

2941 aaatacaaac attagctggg catggtagca catgcttata gtctgacctatttgggaggc

3001 tgaggcagga gaatcgcttg aacccgggag gcagaggttg cagtgagcctagatcactcc

3061 actgccctcc agcctgggtg acagagtgag actctctctc aaaaaaaaaaaaaaaaaaag

3121 agtgggatct gtctcttagg ttttcagaaa ggccagctga ctccattgagagctgctgag

3181 tggaattgct accattttat ggatgtggaa agtgagattc agcatagatcaatgccttgg

3241 ctagggcagg atcatgggct ttttcctaaa gatgcacagg gtctataagaggcctcatga

3301 aattcactcc tttcagggga ggacctccag agaaccaagg aagaagatattttctgttgt

3361 tgttgttgta ccttgtagtc accaagcctt aaaaacacag atcacctgatgacctcatgg

3421 atggaaaatg ctagtgaatt taggtgtttt tttttttaag acattaaacttatctagctt

3481 ttgaaaattt agcattcata cttgtattca ataaacagaa tactctaagacatttttaaa

3541 ttcaatatga ttagataaat gtgagaaagg taagcaagaa ttggttaggaaaaagtgcaa

3601 aggaaaaaaa cgtaagtaga aaaagaaaaa tagggcacag tagcaaggaaatatctagaa

3661 ggaggaaaga aggctcttgg gacatactgt aggttatttg gaatgcagaattcaaaagaa

3721 gtaacctctt gttaccatgc tgtgaaaaat tagtatttct ctttttaacctttagactct

3781 gtttcaggta gatccctgag ctcactcttt tatcctttca acagtaattgggcatcctac

3841 ggtgcacagg ataccatgtg gggctctggg gtagagggat gctgtgctccagggccctcc

3901 tgaggtcagg aggggaaaag gcaagggaag cagccccagg actcagtaagatgagaggag

3961 gcaggagcag cacagaggag gaccccaacc cagctggggt gcgggtacagaggcacctcc

4021 aggagcaggc actcaagctg agtccagggt ggggtggagg gcattccaccaagaatgaat

4081 agcaagaaca aggctgcaga tgaccctgca cagattccag catcagggattctggccccc

4141 agcgtccctt tccttggtgt atgctgctgg aagacaggag ggggcagttctcttttggtc

4201 cttagaaatt tccctataga catcccttct cctgccccta gcagcttataacagcagaag

4261 gccattcaat tctgctcctc tggctggaaa gcaaacatca gcctggcttaccttcgctag

4321 cctgcctgac ccccagcctt ggggtggggc taggttagtg ccctggatccttaaacatgg

4381 cccctggtag cacataagcc tctgctgcct ccacaaccag ccatctccatcatgcatggc

4441 ctggtcctga gcctcccctc aggcagcagc cccagcctct ctgcttcctgagattcagaa

4501 acagggatcc cagggcaggg ctcagggccc agcctcttgg gggcacagtctccagcaggg

4561 aagaggtggg cgtaggtgga caaatacatt cccttcttct tgtagtgtgcccctgtgggt

4621 gggagtgccc cccgccccac atccacccta cctatgctca tgcccactcctctgtgccca

4681 ctactggtgg cagggcttgc ttagcaggga agcagcagag ccctgcagaggggtgggcag

4741 agcctccctt ccaggagctg ggagaagaca cctgaagctg gacagagctttatctgggag

4801 ccggcggctg ctgaataatg aattccaact ctgccgcact cccaggctgcacattgggtg

4861 cacacacaca cacacacaca cgcacacacc gatacacaca cgctgggctgacaacttgga

4921 ggggcggggg ctgtgaggct ctgtgagtcg ctgcaggagc agcttagctcggcttggttg

4981 ccttggtctc tgtgggcagc atcggagggg ggtcgggagg aggaggaggaggcagcggca

5041 gagaagagag aggcgtgtga gccgtgctcc accggctagc tccttcccgctgctcctgcc

5101 tggcagtgcc aggcagccca caccagcatg gccttgctca tccacctcaagacagtctcg

5161 gagctgcggg gcaggggcga ccggatcgcc aaagtgactt tccgaggtagggaagccgct

5221 gtctcagagg gacgccagct ctgagagctg gaccagccca tgctctggaggtggccgggg

5281 ataggacagg gctgggagga tgggtgggaa aagttctagc aggggctggggcgacgagcc

5341 ttttcacagg tagtcatctg cctgggactg actggccatt gtgatttctggaaaatcagg

5401 gtcccctgtt cttccatgcc tgtgtctcct tgtgcttgcc aacatgccagttccccgggc

5461 agggcacaga gccctctgcc tggggaggca gaagtgagga ccacatccctgagctcaggg

5521 agacccagga ccccctcctt ctctctctct ccctctcctg caggttgatttccttgagca

5581 cagggtgggg gccgggtatg gagcctgggg cacccagggt gactgggagaaaccaggcag

5641 ccagtagctc cctgggcccc agagtgatgg gggacactgt tggcttcttttagatctatt

5701 catgggcggg aaccccggga gcccctcgcc tctcttctgt ctggtcttttctcatccttt

5761 tcactcctgt attcagcgac catttattat gatctactgt gtcccaaggataggggtaga

5821 aacacagagc tgagcacaac ccagccccag ccccaaggag cctgcatctgttgggcaggc

5881 gtggaacaag caggacaggt atgtgagaca gaaggtgggg gtgcagcatgcaagctacag

5941 aagcagcacc ctcacccagg ctggtgaccg gtggtcaggg aaggcttcccggaggaagta

6001 acactcagct aatacccgaa ggaccagcgg gtgggagcta ggagaggaggtaaggactga

6061 ggaggcagag gaaacagtgt gcccagagct gagagaggag ctgaaactctggaactgaaa

6121 gaggttccat gtgtctacag ctcagagagg gtgcaggagc ggaggccagagagccaagca

6181 gggcaaggag gcgaggctgg acctgacccc ggggacagcg gagcccctgagcattttaag

6241 tggggaaagg cagggccagg ctgactctgt ccttcaccac ccacctctgcctctccatgt

6301 ggttgctgcc cagccctgag ggttgggggt acttctcact agacatggccccttctcccg

6361 agagaggggt ctgagagtgg gatggggacg aggtggtgag aagggggcagagaggacccc

6421 cctatactaa agagcaaagt gagccttggg gcccaggctg gacacagtgtctgcacctct

6481 gttggaaggg atgggagaga ccattggcag aacattccag caagagccctggggcaccca

6541 catcacctac ccagaggccc tgggatgccc acattgcagc ttgtgttcatagggacaggc

6601 aggggtggag gtgatggcag tggccctgcc ggcaggcgga ggttaggcaggagggagagg

6661 gaggtgtggg ctgggctgcc ttttgcctcc caccccaacc cactgactgctttctctgca

6721 gcaccctgga tctccctctg tgtgccacct gcaggctcat gctggctttagaaaaagcaa

6781 atgtgtcctt tcatctgtga aatgtggccc tgagctccac gggcagcatagtgtggggcg

6841 gttaagctac aggttgccat cctgctgcag ctgtgctgga acggtccaggctgcaccgga

6901 caggcccact tgcaggccga gaaaccaagg ttcaggggta gaacactgcgcgtggcattc

6961 acggaggagc tgaggcacgg tggtcccagc tctcaggacc tcatcctgagtactcaatct

7021 tgcaagctct ttatctgctc ctgggccacc tgggggccag caccttgtctgacacccatc

7081 ttctccttgg agcagtgaag ggctgggcct ttagcctcac tgaccacacaggaattagtt

7141 tatttgcaac ccttgctctc tggactgagt ggagaaatcg cttccaagctccacattggc

7201 aggaggtggc catgggcaga gctcctgggg aagggggctg ggcagcaggaataggcagat

7261 gacaagcagt ttccagaaag tacctttatt acaacgaaag atgcctcagccgctcacctg

7321 tgtcatctag cagttcacag ttgtaggcgc cccaaaagac caacactgaccacaattcag

7381 agggaatgga cccgctctac aatgttcctt agcatctccc agcacatgcaaccactgggg

7441 gccaagcaag tcctctgcag ggggaaacaa gaaactggta aacacgcagagggagacact

7501 ggccccaggc tccccaaggc ttttgagtga aagtcaatgc cgggggaggtggtgagggag

7561 cccttggtga gctgtgccca ttggcagtgg ccctaggtag gccagagcagctggttgaaa

7621 tatggcttga ccttctgtgc tgtgccatcc aagacactaa ggaaagagccctcctgggct

7681 attgtggaaa aagttctgga tatggagtca gaagccctag atcctacctgggttctgcca

7741 ctcaccctca gtttcctcat ctgtaaaatg ggcatgataa taacactcacttcactagat

7801 tgcttcaggg aaaccatagg tatggaagag tttgtgggaa gagtattcaaatggtcgatg

7861 tgtttgtgag gcagccattc ccattctcct tgggagcagc tgctggcccctgaggtatct

7921 tctctccaga ccagcagagg gccccatgtg agatataaag ggaagaggagagcacgtcta

7981 aggggttcca gtctgccagg agaaggcaga gagcctggac tctgctctgtaggagcctct

8041 gctgagatgt tccgcaggaa cccaggcagg cagacccccg agactcctgttctcatctgg

8101 ctgggtgtgc accagctttg cccgtggcca cctcttttcc cactgccctcaggccagtcg

8161 gcccctcggt cagtgctccc agccagttct gtatctagct cttagttcttactgcccctg

8221 gctgctccta agctggtgct gccctgttca tgcatttcct gaacatgctaatatttgtgc

8281 acaggcctgg gaccctgagg tgaaggggcc agcctggccc tccaggagtcacaatcccat

8341 tgggtcagac aggagatagg gagtcctggg cgaatctcta ttgtgcctgcaggccacagg

8401 gctcagctgg gtttctcatt aacaaaatgg agacagtggt cctcatttagctcagaggcc

8461 tgcagttccc aggagtaatc aagagtgggc tatctaagaa ggagccatcttgaccacagg

8521 ttgctactca aagagaggaa gtattagctt caggtatttc ctttatcaactcctgagata

8581 gttccctaca tcaatcacag agccacagaa cgcagggtgt gaagggtcccgaagttcttc

8641 tagtccaacc ttctgtccag tgctgagcac caaggctggg ggacctggactgtaagggaa

8701 ccaagtgaca gacagtccag ggccaaccct gatgtctccc ttctctttctatcccctgag

8761 ccttcttgcc aagacatgag gtttggggat tttctgtgtg agataagaacatctaaaggc

8821 tggatctggc ttccacataa ttcactgtgg ctggaaattg gcacaaaggtttgcagggca

8881 tccccctcca ccttttcatt cttactcttc ttcccaccct ccccctgattcccaccctgc

8941 tatgttccca ctacattcaa cttccagcca ttcccaaaag ataccacacccttttacacc

9001 tccaaacttt gagacatcga tcatatttct tctgcctgga atgaccaccctccaccttga

9061 gaacgcccat taattctgct catccttcaa ggcccagctc atatgctacctcctccatga

9121 aggagtagta ctttgcacac aaagtactcc tctagcagta ctttgcacacattcttccta

9181 ctgctctgcc aaggtacatt gcatttcaga aactggccac acctctgcatgctgcccaag

9241 cttttgagca tcttcaggac agacatcaga catggtttct gtctttgagggattcactgt

9301 gtcatgggtt tgagttcttc cactgtggca ctgtcactct ttggctccatttccccaact

9361 gtgagctctc accccagaac tttctatcca aggaggatca agggactggaagaggcctca

9421 agggccaaga accaagaacc ttggctctta ctccttccat caacttccctaacccagaga

9481 atcttctagg gctccagagg ggcctaacga tttttttttt tttttttttttttgagtctc

9541 gctctgtcgc caggctggag tgcagtgcag tgcgatctcg gctcactgcaacctccagct

9601 cctgggttca agcgattctt ctgcctcagc ctctggagta gctgggactacaggcacacg

9661 ccaccatgcc cgactaattt ttgtattttt agtagagacg gtgtttcaccatatttccca

9721 ggctggtctc aaactcctga cctcatgatc cgcctgcctc ggcctcccaaagtgctggga

9781 ttacaggtgt gagccactgc gcccagtcaa gcctaacaaa tattagcaagttcagctcca

9841 gcccataggt gggaagcaag agggattgcg tgtgtaagcc agagtcagttaggggaagac

9901 agaggaagga gaaagggcag acgggaaagg aggtgggagc aggctctgagttggcccccg

9961 gagctcagaa gggaggcggg agtttttatt gagcagggga aatgggcggtatttaagaag

10021 ccaccgaagg gtcttagttc attggcagga tcaaaggcca tgaaagggccaggcgtggtg

10081 gctcatgcct ctttccgagc cttactgcga ccacacgtgg ggcaggatctcaccatctga

10141 cagaggagaa gaaacataca cacagaggtg aaatgagtgc agcatacaggagggccagcg

10201 gtgggggtaa atagcaacaa tgttcagagg atgacagctt acttagagctacagagacga

10261 gggaaaagga gcaggaggag gaagtgccta agctgggtct tgaaaaactgcccctgtttg

10321 tacctatgga gatgcaggaa gtgaggaatt ggtgatggag gaaggtgaagtctttttggg

10381 tgagggaccg accagaccag aggccagagg aggagaattg cagccaagttccatgtcggg

10441 gaagccacac catgtagctg gagcagaggc tataggaagt agaagagggagaccagctag

10501 ggagggagca gtgggcctgc tgagtgattg tgcagggaag ggttgcagctgaggcactgg

10561 ggacaagatg tccccctact gttggctgca ggctccacct ctgactccacattacattta

10621 ttttccccag taaaatgagg gagccctccc tcttgatgat aaatatagctactatttgga

10681 aacttatctg ccgcccctgg taaaggaggc agaataccca gtgcacccacccctgaaatg

10741 ctcctgcaat gcctaggcct gtctgtgggc tgtggtccag cctagcaccccctctcttgg

10801 agaatgtgag gttggcattg tccctgctga aggcagcaat agaggggacccttacgacga

10861 ccttggcagc cggtggctgg ctgtggacac agccctgcgc ttttgttttagtcctaacgg

10921 atatgccccc tgcatcctcc attcttcaca gcacactcag tccccctcaccacacctgag

10981 ggaaatcttc tctgcctaat gccccacgta gtgaatgttc tcccctcctccctcccccag

11041 agcaagccat tgcacaccag cgaagggcag acagagcaca cagaaaattccccagacttc

11101 tgctttgata ggaagtgtat tttcatgtaa tggaaatgat tgtaaaactgccttcccctg

11161 caaaagccct caggaatatg ctgctggaaa tgtgcttgag aacagacttgcaaatcattt

11221 ctctgaattg ggaagtcttg gttatcttag ccacttttac cgatcatgtgaaagccacat

11281 ctctcgcacc cactcccatc cctgggtctc atttttttct tttttctgtcgcccacgctg

11341 gagtgcagtg gcacaatcat agttcactgc aacctcaacc tcctgggttcaagcgatgct

11401 cccacctcag cctcccgagt agctaggact acaggcacgc accaccatgctcagctaatt

11461 tttgtatttt tagtagagat ggggtttcac catattgccc aggctggtcttgaactcccg

11521 ggctcatgtg agctgcctgg ctcagcctcc caaagtgctg ggattataggcgtaagccac

11581 tgtgcctggc cttttttttt tttttttaac tttttatata taaaaaaactctcaaataca

11641 tacaagagtg gggagaacag tatcatggcc ctatgttgta ccatccaatttcagctacca

11701 tcaattcatg gccaatcttg cttcatttgc atcccatcct acttcctcaccccaaattat

11761 tttgaagaag atcccaaacc ccataccatt ccatctgtaa atattcagtacacagttata

11821 aaagataaga gctcaaataa ataccacata ctttgtcatt ttaaagaaattaataacaat

11881 tccttagtac tataaactaa tcaggcagtc atcaaattcc taattgtctcatcaatgtca

11941 taattttttt ccaatttatt aaaagcttca ttttaatgtg ttttgtaaatcaggtattta

12001 atcatttatc cactcgttct gttgaagggc agccatgtgc cacgcactgggggatggtgg

12061 ggaatgagac agatgtggtt cctgtcctca aagggggaag atgaccactgcacccatcat

12121 catgaggagc tttatggaag ggaggcacag gtgcccaggc agctcatggtgaggaaaccc

12181 acttagccca ggatgggggg aagccacccc agtgcgtgag ccagagtcagttaggggaag

12241 actgaggaag gaggaagggc agatgggaag ggagggagga gcaggctcctagttggcccc

12301 tagagcccgg aagtgagtca ggagttttta ttgagcagga ggaatgggcggtatttaaga

12361 agcccttgaa gggtcgcagc tcattggcag gaacaaaggc catgaaagggctgggcatgg

12421 tggctcacgc ctgtaatccc agcactttgg gaggccaagg cgggggggatcatttgaggg

12481 caggagtttg agaccagcct ggccaacatg gtgaaaccac atctctactaaaaacacaaa

12541 aattagccgg gcgtggtggt gcacgcctat aatcccagct actcgggaggctgaggcagg

12601 agaatcgctt gaacccagga ggcagaggct gcagtgagcc gagattgtgccactgcactc

12661 cagcctgggc gacagagcga gactctgtct caaggggggg aaaaaagccatgaaaggctc

12721 catcccaggc agaggggcta acactagtgc agacgtggtg gtgtggagatgcatcagggg

12781 agtgtggagg ggagaccgga aggcagggca cgggggacgc agccaaacacggagggtctt

12841 tggtgtcaca ctcttagcag gagaatggga tgctaagatc ttgttttggagagaaggctc

12901 tagaggtgag gactgcgggc agggacactg gggaggaagc ccggggcaggcggagggctg

12961 agtgcctcag caggcgccat gagagaggaa ggagcggcgc tgggatcaggggagtgagtg

13021 acagggcagg gcaagagtca attgtggtcc tggggaccac cgcggacccagggatttggg

13081 gtacagggcc ttagttgatt ctcatctaga caggtgccag ttgctgacaccctgaattct

13141 ggcaaacatg gagacatcag ggtggaaaca cctggagcca ctgccatccaggtgggcgcc

13201 ttgagggcca ggccccttgg ctgctttccc agcagcagca tggagcctggcacagaacag

13261 acctggcata gaagtgggag caaggaacac cgcctgtggg tgcaggagcagtgatcagtt

13321 agcaacaggg gcccccctgc agccagccat ccaggcagca ccagacagtgatccatttct

13381 ctcggtgaca gttctagaaa aggctccgga gacagggact atcatgtgatcatttttacc

13441 ctagaccgct tgaccgcttt ctgtctgaac tgatccacct gctagacgctgcctcaacag

13501 tcctcgtttc tattttattt tcttttactt caaagcagaa gggctaatctgctgaggtgg

13561 agacgagttt tcacccactg gctttttttt ttttcagccg aagtttaaggtaaagtcagg

13621 actgcagttt ccacaatatt tttaccctat cggagagtaa aagagtcaccctcccattat

13681 acctcattgt attcccagtg cctggcacag aatgggtact ctacacacttgtggatcact

13741 gggaccacaa gctcctctgt caccgtaaca ggggaatcta ggacccagcagttgatgact

13801 gtgtgggtgg cactgtccaa ggctcaaaga caaataccac aggcccttcctgcctcagtg

13861 ccagggtctg aaaaatggga accagcgctt tcagtcggtt gcagggcaaagtcagagttt

13921 gagtgaggac ctggaagaag ggtttgagct gagccagaga gatgggatttatcatccctg

13981 ccctgcccct gcctctcaga tgaatccctg acccaagcct aagtttccatagtgtaaacc

14041 tggatgttag cagggtgggt taaggggaaa tacatgagtg gaggtagaaatgatatttta

14101 gtacaatttg tggataataa agggttagag ttccatgggg cctccatttagctgagaaat

14161 ggggaaaatg gaaggggtaa ccttttccag tgggaggccc agggactctgcagtatccca

14221 agtctggctc tgtgagtcat tggtgatttt cagagagtat actatgtaagaaacatgagg

14281 aacagctgct ttcttggaca actctttgaa gtgaatttct ttcttctaccatgccatcaa

14341 ctgtcattat aaaattgaag atgtgtttct catggggaaa aaaattgttattacaagaga

14401 tatgggcaat tagacaagtc tcaatacatt tcaaaagact gaaatcttacagagtatgtt

14461 ctctgaccat agtggaattc agctaaaaat caataataag aagattatctttgaaagttc

14521 caaatatttg gaaattaatg cctttcttaa cctatggtca aagaaggaagtaaaagagaa

14581 attatgaaac atttttaact gaattataat gaaaatacaa catattaacatttatcattt

14641 taagtactta cagcagaaaa gaagaaaagt gtaaaattgt aatctaggtttctgccttaa

14701 aaagatacca aaagaaaagc aaattaaacc caaatcttga aaacattatgttaaataaaa

14761 gaagccagac acaaaagacc acatactgta taacctcatt tacagtcaggcatcgcttag

14821 tgataggagt acattctgaa aaatgcatca ttaagcgatt gtgtcattgtgtgaacatca

14881 tagagtgtac ttacacaaag ctagatggta tagccaacta cacacctaggctacatggta

14941 tgacctactg ctcctaggcc acaaacgtgt acagaacgta actgtattcaatgctgtagg

15001 caatcatagt acaatggtaa gtatttgtgt atctaaacat agaaaagatacagtaaatac

15061 aatattataa tcttatggga ccactgttgt atatccaagt ggtcgttgaccaaaacggtg

15121 ttatgtggtg catgaatgta tacgaaatgc tcagaacagg caaatccatacagagaggag

15181 atttgtggtt gtcaagggct gtggggaggg agaatgggga gtgactgctcacgggtatgg

15241 agtctccttc cagggtgatg aaaatattct ggaattaggt agtggtgatgggtgtacaac

15301 cttgggaata tactaaaaac gactgaactg tgcactttag aaggatgaatgttatggaat

15361 gtgaattata tttcaataaa taaaaatcaa acacccccca ccaaattaaacccaaggaca

15421 gtataaaagg aaggaaatag aaaatagaca acagagaaat ttaacaaagccaaaagttgg

15481 ttcttcaaaa aaaattaata aaatagataa accctagcaa gacttatcaaaaataaaaag

15541 caagaaaaca caaattacca atatcaggaa taaaagaggg aatatcattacatttaaagg

15601 aaaatatggg aatattacca ataacttacc tcaataaatt ctacaactcagatgaaatga

15661 ataaatcttt tgaaaaacaa cttaccaaaa ctgacagaaa aagaaatggaaaatccaaag

15721 agcctccata tctattaaag aaattgaatt tgtaataaca atgatgatgatgacaataaa

15781 cttccttcca caaagaaaac ttcagatcta gatgatttca ctgctgtattgtagaaaaca

15841 ttcttttttt ctttttttga gatggagtct cgcactgtca cccaggctggagtgcagtgg

15901 cgcgatctca gctcactgca acctctgtct ccccagttca agtgattctcctgcctcagc

15961 ctcccgagta gagcagctga gactacacgc aggtgccacc acgcccggctaatttttgta

16021 tttttagtag agacagggtt tcaccatgtt ggccaggctg gtcttgaactcctgacctca

16081 agtgatctgc ccatatcggc ctctcaaagt gctgggatta caggtgtaagccaccacacc

16141 cggcctgtag aaaacattga aaggaaaacg taataacaat cttacacaaactctttcaga

16201 aaatagagaa ggaagagcac atctcaattc attttttatt atcaaaacctgacaaagacc

16261 ttacacaaaa agaaaattac agcccaatat ctctcatgaa cacagatgtaaaaatcctta

16321 acaaaatatt agccaactga atagcaatat atgaaaagaa taacacatcatgacaagtga

16381 gtattatccc aggaatgcaa tgttaattta aaagtagaaa atcaaaatattttaccatat

16441 taacacagta aaggaaaaaa ttcatgatta tatcaataga tgcagaaaatgcatttgaca

16501 aaattcaaca cccattcatg ataataacta tcagcaaact accaataaaaggagcttcct

16561 caatctgata aaaatcatcc agctaacatt atacttaatt cagaaatattgaacattaag

16621 atcatgagtc aggcaaagtt ttctactctc accacttctg ttcaacactgtgctagaatt

16681 ctagccagta caaggtggca aggtaaaaac aactcctaca gattggaaaggaagaagtaa

16741 aactatcttt attcacagaa aacctgattg gttatgtaga aaatcctaaggaatctatta

16801 aaaagctact acaattaatg aatgaattta gcaagttttc aggatatatgattaatacac

16861 aagaaaataa attttaccaa agacaggaaa gacttccacc ctaaaaacaaaacaacacaa

16921 aatgctgaga gaaataaaaa aaaaaaaaaa ccaaacatgt agaaaatagattatgtttat

16981 ggactgaaga ttcataattg ttaagatgac aattctccac aaaatgatctatagactgaa

17041 tgcaatccta ataaaaatca caacaaacta ttttgtagaa attgaaaactactttaaaat

17101 ttatgtggac atgcaaatga tctagaatag ctaaagcagc cttgaaaatggagaagagaa

17161 ttggagggtt cacaccacag ctgacccctg aacaacatgg gtccacttatatgtggattt

17221 tttttttttt tctttttgag acagagtttc actcttgttg cccaggctggagtgcaatgg

17281 agcaatctca gctcactgca acctccacct cccgggttca agcgattctcctttctcagc

17341 ctcccgagta gctgggatta caggcatgca ccatcactcc cagctaatttttgtattttc

17401 agtagagacg aggtttcacc atgttggtca ggctggtctc gaactcctgacctcaagtga

17461 tccaccagcc tcggcctcct aaagtgctgg gattacaggc atgagccacttcgcctggcc

17521 atggtttctc ttccttatct tttttcctaa cattttcttt tctctagcttactttattgt

17581 aaaagtacag tacataatac atatacaaaa tatgtgttaa ttggctgtttatgttatcat

17641 taaggcttct ggttaacagt agtctattag tagctaagtt tttggggagtcaaaatttat

17701 atgcagcttt tcaactatat gaggggctgg tacctctaat ccctgtgttgttcaagggtc

17761 aactatattt aattataagt ctaactataa agttaaagga attaagaaagtgtggcattg

17821 gtctaagaat agacatatag accaatggag cagaatagtg tccagaaataaactctgtac

17881 atataaaatc aattgatttt caatcaaggt gttggatatc tagaactaggtatctatatg

17941 gagaaaaaat gaacttcaaa ctcctacctc ataccatcca caaaaattaatgtaagatgg

18001 attatagaat taaacattaa aaacttataa gcttctagaa gaaaatatagaacatctttt

18061 tttgtattct tgggttaggc aaaggtttct taaagaaaaa ttttaaaagactaaacataa

18121 gaaataaatt tcactaaaaa cttgcatttc ttaaaaattg gaaactctctttggctagtc

18181 acagagtaaa aaaaattgaa aactcctatt cataaaaaaa tcacatttaagaaggcaaga

18241 gaaggcaagt cacacacagg aagaaaatat tcacatttat ctgacaaaggacttgtagcc

18301 agaatatata aagaatccct ataagtcaat aataataaga caaattatgaaattttttat

18361 gtaggcaaaa gacttgaaga gacactccat agaataagat agacgtatggccaataaaca

18421 tgtgaaaatg tgatcaacat cctgagtcat tagagaaatg aagatcaaaattacaaagag

18481 atattatttc acatgctcta aaatagctaa aatgtaaaag tctgacagtaatcaaatgtt

18541 gatgaggatg gaacaactga aatttttttt acattgctga taagagtgtgaaatgatgca

18601 atccccttag aaaactattt ggcgatttct ttcttttctt ttctttttttttttttttgg

18661 gatggcatct cgttctgtca cccaggctgg agtgcagtgg tgtgatcttggttcaatgca

18721 acctttgcct cccgggttca agcgattctc ctgcttcagc ctcccgagtagctgggacta

18781 caggttcgca ccaccacgcc tggctaattt tttttttgta tttttagtagagacagggtt

18841 tcaccgtgtt agccatgatg gtctccatct cctgacctca tgatctgcctgcctcagcct

18901 cccaaagtgc tgggattaca ggcatgagcc attgcgcccg gccagcaatttcttataaag

18961 ctaagggtac ctatcctgtg acataaccat tctgttctta ggaatttcctcaagagaaat

19021 aaaattatat tttcagaaaa agactcacat gaatgtttac agcaactttgctcatatagc

19081 ccaaccctag aagcacccaa aagtttatca tcaacagaga aatggaccaagaagttgtgg

19141 tataggcatg caacgggcta ttactctaca ataaaaatca atacattacttatatatgca

19201 acaacatgga tgaatcacaa aaacattacc ttgaccaaaa gaagccagacacacaaaaag

19261 tacattctgt aggatacctt ttatatgaag tttaaaacag gcaaactgatctttggtgct

19321 agaaatcaga gcactggtta ctaagggact agaaatcgac tggaaagggacatgagagaa

19381 catgtggaac aaatggaaat gttctatgtc ttgattgtgt ggcggtatacagggaaatgc

19441 atttattgaa actcattgaa ttttacactt aagatccatg aatgtaagtttcacctagtt

19501 ttaaaaaaag aagagagact cacatctaaa atacctaaaa cttgaaaaatattatataag

19561 atgaggaaaa aaattatttc tgattccatg ctactaaaaa taagctacaaatgtgattca

19621 taatagaaga agccattttt atatttagca cataacttaa aggtctaaaggacaagcaag

19681 ctgggcgcag tggcccacgc ctataatcct agcattttgg gaggccaaggcaggaggatc

19741 acttaaagtc aggaatttga gaacagcttg gccacatgct ggtgaaaccctgtctctcta

19801 aaaatacaaa aaaagttagc caggcatggt ggcacacgcc tgtaattccagctacttagg

19861 aggctaatgc aggagagtca cttgaaccca ggaggtggaggttgcagtgagcggagatta

19921 cgccactgca ctccagcctg ggtgacagat caagactccg tctcaaaaaaataaattcaa

19981 aacaaaatag aatgaaggag aaacaagact atttagtaga ctgagaatagctgtttctta

20041 ttgagggata aactgcacca aatgctattg taagcattat tatttccttcattttaaggg

20101 tgaggaaaca agggcaaaga gaagttaatt agcttcatcc agggcacgcaaactaggaag

20161 aggcagctgg gatttgaact cagggactct ggcccaagag ccttaacctctatcccatgc

20221 cccctcgtgc ttgtaaagga cttgatgctt tacttagact ttcccacaacagtttcttgt

20281 catcctcgtg atggtcccag gacacaggct ggtccaggat aatgacccccggctaacaga

20341 tggtgagtct gagaccccaa ggggttggat ggccagctcc caggcctccagaccatgggc

20401 cgttgtgccg ggccgcacac ctgagtgggc ctggcttttt cctgcacgcaggggtgcttg

20461 ggccctgctt cctggtgctc catgggagta tctggccttc aaaaggaacagatcgatctg

20521 aagtggggag agagaaaata cagcaggacc atcactcaga gagtcgctgtagaggaagag

20581 agggagagga gacgccagga catgggagct ttgtgggagg gaatgggactatttgctgag

20641 ctttgtacag cccagcccag gcagtgcata caacaaggct ttgctgattttaaataacac

20701 aaggaaatag cagccccagg tctgagtcac cagcagagtt ttactctatttctcagctca

20761 cacagggaca atagcaatgg caggcactgc tgggagatag gctagtgggctgggccctgg

20821 caaaatcacg acgtccttga aaacagtccc aggaccttct ccttccccttcggatggccc

20881 accacctcac cctctgccct ttcgggaccc cagcccctct ccagtcttgcttccacaggc

20941 tgctccctga gggcagacca ttcttgcttt tcccttcacc atcgggactcccctgtcctg

21001 tgtccagctc cttggaggct ctactctctg ctctacgctt tcaaacatttccttacactg

21061 ttctctctgc ctggatttcc ctccttctcc ttgcttccca gtctctctgaatatccagat

21121 ttcttctggt cttctagcgt caatgcgtgt gcctctgcaa tgcctccttaatccactaca

21181 ttgagagtca ttgctccttt tcctgtgttc tcactttatt tacactttttgcatgccaat

21241 gacaaaattc tgccttgtat catcggcaga attttccatg tctgatatatctccctctgg

21301 attgtaatac gctcttaaag gcatcgttca gattcgaatg atcttagtacaactcccctc

21361 tgtgaaggcc aaatggcaca caagccagga gctagaaagc cctggttgcctgtggaaatg

21421 aatgaacaca catgggctgg cagccgtgtc cctgcacacc tgccttttctcagaggtgtg

21481 gccctagcag ggtaagctgt ctggaagagg gagctatttt gtgcagatggaacattttgt

21541 ccccttaaat catgtcccat gaaaggccag catggcatcc tgcttctgaaacaagcactg

21601 agctcgtctc catttggaga agatctgtcg tgtgggtatt tttaaatggtgaaaggagaa

21661 atgggtatat ctgataccat ggcacttgtt acactttaag cacagactctgttattcata

21721 ctccatctat tgactcaggg aggagtttat ttcaaaccaa acagctcagctatcccagga

21781 gcagctgcct cagaaggaag gaggatgctg ttctatttcc cccatcgaacctccttctca

21841 ctcgatccac aacagccttt ccatgcaagg aagaggctat tttctttcaagctttattct

21901 ccattttccc tgtggcaaga aaggtgattg gatattggga tttgtaatggttttatctga

21961 aagccattta aaatgaagct ggaatgtcaa caagactgac gctgaatggagtagatgtga

22021 agtggaaatg aacttgaaac aagagatggg gttagtcatc cccctgatcacttggaacag

22081 atgatggagg tcccctgcct ctgctccagt gaacagaaca gaaccacttgaatactgcca

22141 gccactgttt gtacataccc tcctgaaacg gctcttccaa aatgctgaaggacattttgt

22201 tttcttaata atttggcctt tccactgttt ctgtatgatt gatgtgtttcagcaaacctt

22261 ttttaaaaaa gaatatctac aggtaaattt agctcatcat gtttgagaatattcaccatc

22321 tctaaatccc cagggcctaa atcaatgagg ttttagcaca ttttgaaacagaaccctgat

22381 gtataaattc tgcaatggct gatttcacgt attttacttc ctctctaacaaagctatgga

22441 aaaatgcaca agcaggggag ggtttgatcc tcggtgtttc ctgcagatgtgaatctgaca

22501 ccaccttgga gcagggcccc tccccacctt ctcccaatcc tccgctgggttgctgcattt

22561 ttcactccaa gagaccccgg aggacagcta tatccgaggc ttattaaaatcttctaggat

22621 gcaaaggcct ttggttattc agagcagcag gtctttaggg gaagcccccatacacaaaca

22681 tgctcagctg attctcaatt tatattgtgt gttacctgcg gggaaaattaaaagctcaaa

22741 cctcaggcac tttccctctc ctcccttgat tgcccggggg cttgttgttgagatatttct

22801 tgttgatttt tttgtttttt atgtctctgg ctggtgctaa acattctttctttcccatca

22861 tgtttacttc acatctcttt gccgtataga tagcttctgc tttatggttttttcctcctt

22921 atctcagatg cagccagccc ttccccacct gcccccgccc caaaacacacacacgaacac

22981 acaccctttc agactgcatc cacactctct gtttcagtgg atctgacatcaacgaccccg

23041 ccacccccgg ccctcgtcag aggggagctc tgcattgaac taggactagctcctgggtca

23101 taaaagttgc taggaccctg gagagctctt actaaacaga tgaggccaccactgacagag

23161 gagagaggtc agttcccgga gggaacgagc ctgctttgct gagcccccttccttgcccag

23221 cccccagacc catcacaggg aaggttcaga ggagctctga cccctccagtacctccttgg

23281 cctgacgccg ctctagcccg ggctcccagg ttttctgtag ggagaggagcacagtccgct

23341 ccacccatgc catgggcttc atcagtgaca acccaaactc acccccaaataggaatggct

23401 tcaacctgga gacagccctt caatgaaatg gtttatgctg gtggagatttaaaggtattc

23461 gtctttcggc tgggcgcggt gactcacacc tataatccca gcactttgggaggccgaggt

23521 gggagatcac ttgaggccag gaattcgaga ccagcctgac caacatgcgaaaccccatct

23581 ctactaaaag taaaaaaatt agctaggcac agtggcgcat gcctgtaatcccaactactt

23641 gggaggctga ggcacgagaa tcatttgaac cccggaggca gagtttgcagtgagccaaga

23701 ttacactact gcactccagc ctgggtgaca gagcaagact ctgtctcaagacaaacaaaa

23761 agggtgtttg tctttcaatt gcaaaaatca agcatggtca ctgaaaaaaaattcaaattc

23821 acatttcatt ttgttttgtt ttgttttgtt tgtctttcag ccaggtgcagtggctcacat

23881 caaagtatgc tgctttcaat atcttctcac tctccctccc cagggataaccactttcttt

23941 tttattttat ttatttaact tttttgagat ggagtttcac tagttgcccaggctggagtg

24001 caatggcgca atctcggccc accacaacct ccgcctcctg ggttcaagcgattctcctgc

24061 ctcggcctct tgagtagctg ggattacagg catgtgccac cacacccagctatttttgta

24121 tttttagtag agacggggtt tctccatgtt ggtcaagcag gtctcgaactcccgacctca

24181 ggtgatccgc ccgcctcggc ctcccaaatt gctgggatta caggcgtgagccactgcgcc

24241 caggggggta accactttca gtggtttgag atgtttgtct cttcatagaagaaatatatg

24301 catatagttt gggttttggt atttttttta attaatggag ttctaatatacatgctgcct

24361 tttttccctt accatggaat tgacacagga taataaatta attctaagcaacaaattttt

24421 ctttaaccca tcctgtctct aggtttctcc tcacagaaat tacaaccccttctcttgtgg

24481 ttccatccca tccctaaaac agtatttatc ctcccttctc tgtaccattactgtttcttg

24541 tgcgaaattg taccttggag tatgtactga atggtgttgt actggaggcctggcgcggtg

24601 actcatgcct gtaatcccag cactttggga gaccaaggtg ggcgggtcatttgaggtcaa

24661 gagttccaga cgagcctggc caacatggtg aaaccccgtc tctactaaaaatacaaaaat

24721 tagctgggca tggtggcggc gcctgtaatc ccagttactc aggaggctgaggcaggagaa

24781 tcgcttgaac ccaggaggcg gaggttgcag tgagccgaga tcgtgccactgcaatccagc

24841 ctgggaacag agcaagactg catctcaaaa aaaaaaaaaa aatggtgtttcccttgcact

24901 ggtgccctgt tggctcctgg cctcccttct agaccatcag ctacctgtgggtgggagcct

24961 gtgcctttgt cattggtcca tcctctatcc cgaggccccg ggacatggcctagaacatca

25021 gagactccag cggctgtttc tcaaagtgaa ctgaactagc tggtgtttcccacacgatgg

25081 agccccctcg acctgccctc gattctctcc tgacttattt ctccccacatcttgggccag

25141 ttccagctgg actagcaaag agggcagctt tacctctgtg ctcccaacatgccctagtgg

25201 gtggcgtatg gatgggggag cctgggacaa tgtgtgtcca tctcacacactctctacttc

25261 ccatgccagt ggggaaagtg ggggcaggaa tagagcccgg gagggaactgccagagactg

25321 tcttctctgc taaggctgac aggaagacgg acaaccatga cagtggtggaaggggaaggc

25381 ccttggccca cggggaatgg ctgtctggaa gctgacttgt tgttgggggcctggtttggg

25441 caggaacccc tggggtggct gcagaaggag gctgggcttc acagacccctgtcggcaggc

25501 aggggctacg ccccctatac taggcttctg ctcagggcag cagggcccggagccaccagc

25561 agagctgagg aggctgcaga ggaggctgag agatccatgg aggaagaacatggtggaaaa

25621 gagtgcctga ggtccgcttc cacggccact ctgaccagcc tgggccttctgtgccttagc

25681 attcccgttc ctaacatgga actcatggcc tttgacccgc ttccctcacgaggctgctga

25741 gagggtcaga gaagaagccg catggggact ggcctcaccc tgggagaggtgagcaagcca

25801 cgaggtccca tgttgcatga aaagtcaaat gctgttagga cgactcccaggatgaggagg

25861 tctgacccca tgctcatcgt ctggacagct ctgaccctag aatttatttcctctttcccc

25921 acagggcaat ccttctactc tcgggtcctg gagaactgtg aggatgtggctgactttgat

25981 gaggtaggag gcccaagact cccccctccc tcagccctga gcccagaggggaacagccac

26041 ccttcgctgc ctcttgcggg cacacactgg ccccaaatcc caggcactggcctgctctga

26101 gcccctcacc tctcagctgc ttcctgaagg aggtggtaag gagggtgtgcaggaactccc

26161 tcccccatgt tccccccaga aacctctgca caggtgaggc ccgtgtgcaaatgacacggg

26221 gaacagcagc ctcgcccacc tcgacggccc tgctgggtct gggcctgttattccctgtgg

26281 agaaagagcc cacaggtgct gtagacctga atgtgagcca ccagctgagggcccaacgag

26341 gcaggcgagt gttggggacg tcgcaaaggc cagtctgtgt cagtccccaggggttgaaga

26401 gcagggcagc cccgggcact gaggtaggag ccccagtcac cagggaaacattgtcaagca

26461 ccccacctga gtgagggcgc catctccaga ccttgagggg aagcatagggaacagaagac

26521 agtctggatt ttcagaaaca gctctggggg ttccatgaga aaagacgtgagctgctggtc

26581 tattgacaac gatttttctc aatcctcact ccagctgggc tgttgtcacaattttatcag

26641 caaaggagca ggcgacacca tcccacaggg gtgcccagga gcagtgagaggacttacaac

26701 gcttccctct ccctgccctt cccctcggta cctggccggg ctgggagccctatcctcaca

26761 cacacacacc agctcgagca gcctgcggcc tcctccgcct cctcacattctttcgtctat

26821 gtgtttgctg cttccagaat ctatattccc ctctggctgc tgtaggttctccagggatga

26881 ctttggagtg agggccagca gtcatccgtc accatcttag cacaaactggaagccatgta

26941 gtgaccctca aatagtgtac cccctctctc ctggggttgg ctctcccgcttggctctgtg

27001 ggggctggga agggcctcat agcagactgt gcctcttgag gttggctgctggcgttcggc

27061 tgagcagcca ccaggctgac acttggcacc agctgtctcc ccctcctccagaaaccaggc

27121 cacacgatgt ggctgtgtcc atcgacccag agctggagac acagggagcaaaacctcgct

27181 cctcactcag gcttaggcac agccatcaac catcgcggcc cagcaccacaccctccccaa

27241 ccacttcagg gcgcagttgc cacgacctcc ctggtacgtc cccactgctatgcaggacag

27301 gtgaatcact catttaaagt gaatcactag agctaaggaa gtttctgtccttaccttctc

27361 cccctcctgg ctgtacaatg acctcagttt ctaaacctgc caccatctttgtcaaatggg

27421 gttggtgatg ggtgtgaagg tctctgtgaa atgatgaaca aaatgaagggttatggtgag

27481 agtggaatca tggctgccca ctgagacagc tgtcatagat gcttcaggcttgccccatta

27541 cacacccggc ctgctccctc ccctccccat ttcctcagtc agggcactgggctggctggg

27601 agaagatgcc agcagcctgg cccagtttcc catagtccta cctccctgggcttctgccca

27661 ctaatccacc aggcacagca tctgactccc tcctcccaag actcccaggggatatgtcag

27721 cccaggcgtt cagccagggg gcaacctgat gccccttcca agggcactgccacccttttc

27781 catgcccagc gccttggaca cctgagccac aggtatgcac gacattcaaagttaatcacc

27841 atgtcgttcc tcttcccaac tccgcccagc ctgcctcagg gggagagtctgtctctgctg

27901 gccctgaaca aggggccaca ttccgagcat ctagtgcatg ccaggccgggcttgagatat

27961 cccagaggca ggaacctggg ctcaacaccc catgatgatt tgtatgggagcttagggatg

28021 gggtagccag agtcagtgtg gagagactgg ggcagggcag aagcagttatggaagaagca

28081 catgactagg gtcagagagc agggcacgcg atggggagaa gaggctcctgcccggggaaa

28141 gtgctgcccg cccactgggg agacagggaa gtttctggtt gttgcaatgaggagcctact

28201 ggcatttagt ggggtgggga gcaaggatgc agaatgactt gcaatgctcaggccatcccg

28261 cacttcccac ctgggagccc cgtgggaaga tggtggcagc cccagcagcagcactgagct

28321 gcttcccgag ccatgcccct tccactcaat ctccgaaatc atccacagacgaaattaggc

28381 tcagatggta actacccttc cccaggtgac agagctggaa gcggccaagccagggttctg

28441 aattcatgca tagattagac ctaagccctc tctggataca gtgatagggcctgactccca

28501 ccacccctgc aaggcccgtg ttggagtctc tccacacccc ctgcctccatttctccctgg

28561 gcaaagtggc ctcagccctg gccaccaatg gtcagcagtg cacatcccacaaagcaggaa

28621 ggccaccctc ccattccctg ttcaggaacg gcccggaggc ctgggtcagcccagtcccaa

28681 aggtagcctg gagccatacc ctggctttaa cctttctccc tagacccagtggacaagttg

28741 taaacttccc tggcttcccc ctgaaagaat ctgcctgcca gtggttccagaatatcctgg

28801 gaaagagccc tttcaaatcc ccctgaacct tcttgacttt ccagaaagcctcttctctcc

28861 gtcttactct gcccagggcc tgccggagcc agcttagtgagacacactggcctgggagtc

28921 atgagaccta caccacagtc cttgctgagg aacctctttg ggctttggattccccttctg

28981 taaaagagag atatgctccc tgctctatct gccccacggg actgtcacaaggctaaaaaa

29041 agatgaaatg agagacaaga aagcaaatgt ctctcacagc tctactaggtaaggggttcc

29101 aagcaaggga ggggcccctc ctctgctcag gcatgggtga gaggggctgcagcagctggg

29161 cttaggaacc tgagtgggga ggaggatgcc atggaagaaa gacaatgctctctacaacaa

29221 tgggtggaaa cagagcctgg acatggtgtc tcctttccca gaggctggaacctgagcccc

29281 tacatttaac ctacaactct ggaaaagcta gggagagaca gagaaagacccagcctttgt

29341 gacctgggga aacaggagta gccaccttta gccagtttgg tttggctctaacacaggccc

29401 tgtgtggagc aggccccagg ggagaggcca gagtaacaat agtacttgtgccaatgataa

29461 gaagaactgc tgctatttac tgagcactta gtgtgtggca agatgggctgagagcttgac

29521 acaagcatta gactcactag aacttgctgg attggtagca tcctaggtgataaggagcca

29581 caacaggatt taaacccgag tctatctgat tccaggacct atggtcatttgtaaagtaga

29641 caagactcag ccctgccctc aaggggctca gtctagcggg cagatggacccactacaaac

29701 aaggagggac cctgggcctt ctgagccaag aggaagaaga ggtctccagcctgggggatg

29761 acagggcagg ggagtttggc cttatctgcc cctttctgct tgtaccaggaagtcatggct

29821 gttacctcct ggaggccaga aacgcacctg tcttgttcgt cattggcctggcacccagca

29881 tggagttgag aaaatgttgc cgagtgaaag aatgaaaaaa acagtgacgttcactaggac

29941 tggcacctgt caccgcaggc ctgtgcccag accgagtggg ctcagcagggctagtggtac

30001 atcaagccct ttgctgtggc ctggatagaa aggaagcagg caaggcacagatgagatcac

30061 ctaaagggac tttagatcac cttgatctct aaggttagag atcatctagtttaaccctct

30121 tgtcttgcag ttgaagaaac aggtcttaga gtggggaaga gaattgcccaagaagaccag

30181 ctgagatctg agatcctaca tttaacttac aactctaaag aagctggggaaagagacaga

30241 gacaaagaca gaaacagaga gagagagaca gagacacaga gacccagcctttgtgccctg

30301 ggaaagtgaa atagccacac tcgggatact gagcccaggc ctttaagcttgcaaatccgt

30361 ctctttccat tgtactctaa agcagcagtc cccaaccttt ttggcaccaggggctggttt

30421 cgtggaagac agtttttcca cagactggga tggtggtggc tgggggttatttgggatgaa

30481 actgttcctc ctcagaacat caggcattag attctcttaa ggagtgcacagcctagatct

30541 cttgcatatg ttgttcacag tagggttcac actcctatga gaatctaatgctgtcactga

30601 tctgacatta gatggagctt aggcgggaat gctcgctcac ccgcggctcacctcttgctg

30661 tgtggctctg ctcctaacag gccatggact ggtactggtc tgtggcccgggatatgggga

30721 cccctgctct aaagctttgt agtgcatctc aatattttcc cccaaacctatagccctgtc

30781 cctttaagga tgctaccttg ctgatttagg atggttccag gcccactcagcggccaagct

30841 ggacataatc cagatcattc tccaaggtac atcagggaaa ccttttttgcagagtcctag

30901 atcactgggg ctgataggat gcagaaccct gtgccccggc cagcaccagccaggtcaggg

30961 ctaagcctag accaggaaac tgggtcagga ctcagcactc cccgggctcctgagatcact

31021 ccctccaaca gaggccctct ttccctccct atctgtacta cctaccaccttgcttctgtc

31081 aacagtccta tcccaggctg ctattccagg tctgtgtctg tctccagaactatccaggac

31141 catccccagg actgagaaac aaccctgcat ccctgcgttc tgcacagcgtcatgcacaga

31201 gcctggcaca cagcaagtgc tcagcaaatg ttcgccccca gcatggggcttgctggctcg

31261 tgacatcttg agtgactgtg tttggcttaa ctgctacttg agtcccccagcagtaccagg

31321 cttcaggaga ggattcagtg tagtggatta agccctgagg actgaactccagactaagca

31381 tcctgagact tgagtttgaa tcctgcctct gccaccaacc agccttgtgcccgcgggcaa

31441 ctctcgcctc tccactttcc cacttgtaaa aggagcacat ctttgccatgttgctgtgag

31501 cttggttatg ggtaaatgtg ctctggaagt actaagtcct acccagatgaaattcttcct

31561 tcagaagccc ttttccttca gtcttttttt tttttttttt ttttttgaggtggagtctta

31621 ctctgtcacc caggctggag tgcaatggtg ccatctgggc tcactgcaacctctgcctcc

31681 caggttcaag cgattctcct gcctcagcct cccaagtagc tgagattacaggcatgcacc

31741 accacacctg gctaattttt gtattttagt agagaccgtg tttcaccatgttggccaggc

31801 tggtatcaaa ctcctaacct caaatcatct gcccactttg gcctcccaaaatgctgtgtt

31861 tgcaggtatg agccactgcc cccagccccc tttccttcaa tctaatagctcacaagttca

31921 ataccatagt caggagagga gtgtagctcc caaaccctca aaatcctcatctcgtcttgc

31981 tgtgttctca gcatatcacc ccaaatggag gaaaggacat aaccacaaaaatgaggagac

32041 aatgaaaaat gaaattaggg aagagaagat gcagtgaaag agacacgtgaaatccacagg

32101 ccgaggcaga agaggaaagt gatggcggcg aaggggaggg aggtggcatgacaaggagac

32161 aaggcagttg cagacctgca cagagttccc actgggaaga tctaaactaaacacattctg

32221 ccgtgctgtg tcacttacga ctgctgtcac ctgtgagatc ccatttgattctctcaatag

32281 ccctctaagg tagatattgt cacccccctc ttttcacaga tggggaagctgaggcacagc

32341 tagtgagtgg cagagccagg gctagaactc aagtctcctg actcaaactcagagtttctg

32401 caacaccacg gagactccca gtctgcgtga gatacaagcc tcggtgttgtcagaagaaca

32461 aaaaagaagc aaagggtggg catgtccttt ggagctctgt gaggtgcccagagctcacag

32521 aggctgcctc agcaaaggaa ggtgtcagca atgggagatg gggctggaaatgctgtctgg

32581 gcacagcaag ggggcctctg ggtgctagga aggggaatcc ccacctctttcagggagctg

32641 tagaggagcc actgaaaagt tttaacaaag gagagataaa aagagaggaaaattcaaccc

32701 caaaagtctc cttcttacag cccatgcctc tacttccagg gaggccaaatgggagtaacc

32761 cccagtccca gaccctgagt cacttccctc cagccaagag gcccgtcaccctccgaggcc

32821 ccacactgat gccaggaccc cacctagagg tgccggcttg atcggtctccaggctgggcc

32881 ttgggatttt taaaagcttc tggaatggat tgcagttcca gccaagatgaagaacccctg

32941 agaaagacag agggagacag agacaaaggg agagatagag acagagagagaaactgatga

33001 aagaaaacag atgtggtgag gagaagaaag cagacgaatg atgcgggagggaaggaaaag

33061 aaatgagggg aaagcctcgt gtgggtggaa aatgcgggag ggagacaggggaggaaagaa

33121 aggaaactgt aaggtgggag caagtcagag accgaagaag ctgctgtgactcagtgagga

33181 ccctgtcttc tccctcaccc ggaaagcctc caagaagaac attccccgctgacataggca

33241 tggactgccc agacccggct gacgaatttc tgaaagggca cctgagccacacacctacac

33301 acgcttcccc tgattattct catctgcagt caggggcccc ggaagccccctgtctcctgt

33361 gccctccctg tcccccgact ctcactcaac aaactggccc tcgccccgcagccaggcagc

33421 ctccctcccc aggtccctta gcctcagcct cccgccaccg ttcaacaccccacctccctt

33481 tcacagggcc atctccaaag tcatgtcctt tttctcctga tctttctctccttccaatgc

33541 caaaatccca cccacagacc ctcaggggga ccaatcaccc ctcccctcttcatccccagt

33601 aaaccaaatc tcggtggctc ctgcggcccc ccgactccca cacagcgccctggctgatga

33661 gctgggcctt cctgggctgc tttatttccc tgcagcccca taaaagcagcttcattaaga

33721 aaaccacaca ctctgctgag ctgccagagg catccagaag ctggagccgcagccgctgaa

33781 tgaggcctgt gggccgggct gcctccactt cctgggactc tcagcgcacccctccgccct

33841 gtgcccacct cgcctctgaa gccctcccta ggccctgctc agaaccctccccaccccacc

33901 ccgcagaccc ctctcccgct cctctgcttc ttcctccctc tcatgccaaggccaggtcct

33961 cccttgccag tcctgaaggg agatgtcaca aaggccgttt tcctgagacaggccctgccc

34021 acactgggca gtgacccgcg gtgctggccc agtgtgccca agccctccaagtccccaggc

34081 tgggagaagg aatctcagct ttgggaatgg caaacgtgca gggtgggctcacagaagcct

34141 cctcccgagg gcctgctcag ccagcaacag agtgctccaa gtcatgcatctgctctgagg

34201 ccgagttcct tgtttataga gcacagaagc cattacccac ctctccggccattggaaaga

34261 ctaaatgaat gaatatgcac gtagagcatt cagacctctg cataagaaaaagttccccag

34321 aaatggcagc gattattact attattattt attactggac tattgagcagtctgaatttg

34381 gtagggtata aaaatggaac taaaaaataa aaagtcactg ccttctaccagatctgtcaa

34441 aatcctccct gacacggtct ctccacagcg tcttgagcag acctcagcgttgtctggtcc

34501 tgtccagaag ggcttcctac tccagtctgg catcctgttc acccctggccatcctccttc

34561 cctcatgctt gtggctcagg atgtggagtg ggacagggac ccctgctgaggccctccaca

34621 tcctcccctg gtgggcagcc catggaaaaa ctgtcctcat atcactctaccccacttggc

34681 caatggagcg caaatagatg acttgccaca gccaacagtg gcaggctgggctccttgccc

34741 tgctgtactc tatgggtctc ctgccagtcc actgccctgc agatgccactggggatttgc

34801 atgccatgct gcccctcttg caggtatcta atcaccatga gctgtttccccaagaagtac

34861 cacaaaaaca ctacgcctag gacagaattc ttcccacctt tcccttgcccagtcttcttt

34921 cccatcccag gaaggtgggc tgggtgatgg ttggaggtaa cagggcctttgaggaagccc

34981 taggaagatg tctggctctg cccattggca gctttttaca gaatggggcactgggccact

35041 ttagcctctg ttttgagcca ttgttgccac ttctagggca ccaggaaaaatcccaatcaa

35101 attcctactc atcattaaca ttgagttagg gaggaagcaa cgaagaagtggtaagggtga

35161 atctagaaac aatgagttgg ggacaggctg tgggcctgac cccaataacactaatcagct

35221 caaacctgtc cccagtgtta ccactggcag agtgaggagt ggtttgaactcaacacagga

35281 gtctggggca gagcctgtgc cagtcagggt gattctgatg agagagagctggaagctcac

35341 agctccattc agcacccacc aaaaaccagg ctcacaccca cattccttgctgtctccctg

35401 ggacccgacc accaccctgg ttgcaccacc ctctcccaac ccccctcaggagctgggagg

35461 ccatggaagc agcgctgtgt agggagtcaa aagtcctggt aggtccaggctcttcaccta

35521 ccacatgacc ttgggcaggt cctccaacat ctctgagcac catctttgaaagaggagtgg

35581 gcaacaatgc cggctctaca aggtggttgt tggaactaaa tgagattccaggtgtcaatg

35641 ctttgtccct ggggagcact gggcccaagt gaggggccac tctgactgttggagatcccc

35701 acaagagatt cccctcccac accccacggc tcctacctgt tattgccaccgaagccgcag

35761 ttgtccctct ctccccagac atttcggtgg ccggtggcca gcagcatcgacagaaatgag

35821 atgctggaga ttcaggtttt caactacagc aaagtcttca gcaacaagtaagtgtgggat

35881 ggggcaggag gggctgggcc tggacgggct gggagcctgc tcttctccttgggctaccct

35941 ctgtttgggg cttaaaaagg ggacctacac tcccaacctg ccctggattgatcttcaaag

36001 accgaagaaa tcttgggctg gtctttgatc cccattttga tccctcttcttgtcttcaga

36061 atcccccagt tctcccagct gctgtcagcc aagaacactc caccctcctatcacctctgc

36121 tgtctccaac cccatcaaag cttcctgtct taaagactta aagctttaagtctccctcaa

36181 tgccacgctg gggtacagtt acccactgga gaggcgaaag gtggaggggctgatgatctc

36241 ctccaagaga cactctgtag ccctgagggc aggcttgaca gtttggggtggtggtttagg

36301 agtcaggcaa gcctgatctc agacactcag gtcagtcatc tactgtgtgaccctggaaag

36361 gttacataac ctctctgatt tcaatgtgct catgtgtgaa aaggacaagtatttacctca

36421 aagggcagct gtgtgaatta aatgagatag atattcactc actcattcaacaaatgttta

36481 ctaagcgtcg attgtgtatc aggtactgaa ttaggtgatg cagagggcggggtgcctacc

36541 ttcatggagc ttgcactcca caagtgaagt acacctgcca tacgagcgttatcactataa

36601 ggtgttcaat aaaagtagtt gtcatccttc tctctgggcc atgagaagaattcagaagga

36661 tttgaacacg ctggaacagt ggctaagtaa tatcttgggt taaaaaatcacagccaggtg

36721 tggcacacac ctgtagtcct aggtccttgg gcagataagg cgggaggatcatttgatccc

36781 agtaatttga ggctagcctg ggcaacatag tgagatccca tctctttaaaaaaaaatcgg

36841 ttgctcttat acaagctgga ggtcatggct taactgtaac atgtccaagaaggtatggag

36901 gtgttagctc actgaggact cagaatgact caacagtggg aggagactacaaacaaaaga

36961 aaagtaggcc tcatcctaaa tcatactaat agaattaaag cactcctgatctgagcagga

37021 gagacaagga gtccactgct ctgatactag tggcagagaa ttcctgtaggcaccacccta

37081 tagtttccag gaggaaaggg actttaagtg ttaccttata acaaatggatgagagcctga

37141 aagggaaaat catagaggac atattcatcc attcatccat ccattgatccattcatccat

37201 ccatccatct atcattcctg ttattcatcc atctgcctat ccatttgtctgtccatcaat

37261 tgatttatcc acccttcctt tctttcatcc atccttccat cctttcatccatccattcat

37321 caatccatcc ctccatccat ttatcaattc atttatccac ccatttatccatctatccat

37381 tcatccgtcc atcctttcat tcatcctatc catccactca tccatccatccatccatcca

37441 ttcacccatc cttcctttca tccattcatt catcaaccca atccttccatctttccatcc

37501 attcatccac cacttaccct ttcatccttt ccattcatcc ttccatccactcatccatcc

37561 attcatccat ccttccacct tttttctttt cctttttttt ttttttttttttgagacaga

37621 gtcttgctct gtggcccaca gtggagtgca gtggcctgat ctcggctcactgcaacctcc

37681 gcctctctgg ttcaagcaat tatcctgtat cagcctcctg agtagctgggattagaggtg

37741 ctcaccaccg tgcccagcta atttttgtat ttttagtaga gatggggtttcaccatgttg

37801 gccaggttgg tatcgaactc ctgacctcaa gtgatctacc ctcctcggcctcccaaagtg

37861 ctgggattac aggcgtgagc caccactttt ggcccatcct tctatctttccattcactga

37921 tccatctatc gatccatcca ttctttcatt ctttcatcca tccttccatccatcatcctt

37981 ccttccatcc attcatccat cctttcattc ttccatccat tcatccatccatccatcttt

38041 tcacccaact ttgcagtcac tcatcataca tatagtgaac aaatgctttctgccagtcag

38101 acactatgct agtcactgga gatactgaga tgaggtattg aggcacagtccctgccccta

38161 ccctcccaga aggctttttg ccacaggaag aggaaagaaa ggtgtgtacctagaggcagg

38221 atgaggaaca ggctgctgga agacagcaga caactgaaag atagccagtattttccagcc

38281 aatgtgctgt cttaggaggt agtgagctcc ttgccactgg gagagggtgagcaaagagtg

38341 gaccacattg tagaggggat ttctgagtca ggaaaggccc caccatatgggctccaagga

38401 gtctctgatt ctgtgggttt tattaggagc tttcaaaatc tcagctgagtatggggcaag

38461 ggcatttcag aaatgctgtc agggccacag ggaggatgtt tagtgcacaaaggccttccc

38521 tttgcctctc atggcatcac accattcagg cagctgcttt tggcacccacaagcaaggtt

38581 ggtgagacac cccccaccag gggcccccaa ggtgaagcag agccttcttccctggggtga

38641 gataccatga gggtgtgacc tatgaggaca ggagaaacag gaacaagtggaaggctcaca

38701 cacagaccaa gtgggtgtga aaaaggaagg agaatcggaa gtcaagcaccagggagggca

38761 cctgagagcc cctgaaggaa cccaaccata ggtgccaaag catccaggagctttacagct

38821 cagccactac agccctagct gtgcaggagg ggaaaccaag tctcagaggggaacctgagg

38881 tcacatgggt agacaatggt agagccaggg ctagaatgca tgtctgttaacttctcttcc

38941 taatccaact cccagaaacc aaaatatttg agcagtgatg gtggaaactgagggcatgga

39001 agacattgtt aaatcattta taatgaaagc caccagccta accactgaaatgctggaaac

39061 acttgagccc atcaaaagac tgctacaaac aaatcagaag tatttgggaaatcgggaaat

39121 tgactcccat gcagtgaata tgttgaaagt tacagcttct attaggtgtttttggttttt

39181 gttttgttca gagacagaat ctcactctgt cacccaggct ggagtgcagtggcctagtct

39241 cggctcattg caacctctgc ctcctgagtt caagtgattc tcatgtcttggcctcccgag

39301 tagctgggac tacaggtgca tgccaccagg cctggataat ttttgtatttttagtagaga

39361 cagggttttc cccatgttgg ccaggatggt ctcgaactcc tggcttcaggtaatagacct

39421 gcctcagctt cccaaagtgc tgggattaca ggtgccagcc accaaatccagcctgtatta

39481 gatgttctta agtgccaata agaaggaaga cagaaagggg aatagttcctatcctaactc

39541 tcctcttctt ccctccctgc ccccatccaa gagaaggcag gaaaccccacaaggggaggc

39601 ccaggcctgg tgggagaggt tctggcattt ctttggaagc ctagagaatgcccagggcac

39661 tgctggctgc agagctgaga tgggaaagaa gaggtcccct tgtggagagcacaggcccag

39721 gctgacacag gccagcttgt gggggtcaga gtgggagaga ggtgtttggaatgatgtgag

39781 actcaagtct ccccatcctg gcatttgcct gggccaggcc agaggagcaatgaggccact

39841 gccctcaacc cccacatggc ccagttcaga ccccaggctc cttctcatggggcagctgag

39901 tggaaggggt ctttggggtc tgcactaggc ttagcaatga gcaaagccatggccactgct

39961 ggggacagtg cctggcacat ggcaggctcc tgattatttt gtggaataaaagaatgaata

40021 aatgcccctg tggtgttagg aggcagaggg taggtataca aggtgggagagcctttgaga

40081 gggaatcgga gtggcccctc ttctctgaag gactcagggc actcaagggtgacactcagc

40141 atcacatgac cgatgcattt ggggaaattg agctaaaaga ggcatggaggagctgcctgg

40201 gagagtgggt cccaggacga gaaatgagcc tgatcccatc actgccatctcagagagaga

40261 gacttgtcct agaagcagag agtagcttgg aaactggccc ctcacccagtggttctagag

40321 gctgccagga ggcagagaca tggtatgaag gaaggaggca tcctaggcagaaaccaggag

40381 acctccaggt ctgcttggcc ccgtttggaa caaagacctg tgtccaggaaccttgggctt

40441 ccccatgaga aagaaatgtt cggttcagaa gattttgtgc atccagctctgcctgtccgg

40501 gacctctgag ggtccatggc ctggcctcca gcctcctgcc tgctaaggatgccagggacc

40561 ctgaataatt caggagccag gacagcagga gaggcctcgc agggcccaggacacctgaca

40621 cgggctccca ggggaaagtg atgaattatt gacaggattc tggtgcccagttgccgctct

40681 attgtgatca gtctgtgggc ccatctgggc tggaggcctt ttcctgccggctaattacgt

40741 ggggatctta gctctgccca gccgcccagc ccctcgtggg gccagacagcctcctgtgag

40801 gggtgtcctc tttgccatgg tgacctggat ggccctgtaa ggcaagtagtcagaggacat

40861 ggagttagcc ccagatcctt tgcctgacag ccccagggaa actgaggcccagagaggcct

40921 cttgtccagg gtcacacagc aggttcagga cagtcaggtc ttcaccccaggcctcctgac

40981 acccgggcca gtgctccttc ccacagaaca catggcctca caactccatttctagggaaa

41041 tgactcagct gtctaaggag catatgagcc cacccttcct caatcgtcctgggccccact

41101 ctcccaggca gctcctccat gctgacccat gcagaggagt aagaacctactatgtgtgca

41161 gccaggatgc acaaaggcca gctgcggcgg gcagggtcgc ctctggggtcaccacaaggg

41221 ccagagccag gggcttctcc tacctcttcc tgtcccagct tcttcccaaagaatatctat

41281 agaagacggg ctgagggatg gcatcctaga agcagtgcca gggcctttgttttgaaactg

41341 ttttcatggc aagcactgtg tttttgctta aatggtatgt tacagacctgtagaaagagt

41401 caaggtttat aaaactgctt ttctttatac tttacataag gctgagataatatcaattgt

41461 ccatgtcaaa aaatataatt tttactttta tttgagagag gttggggggtgaactgttag

41521 gagttaaaac cccccaagcc actcttggag gtgtggcaaa ttgattcctttaatcttgca

41581 agctcctagc gtcccagtcc caccctccag gccatagaca agctctggctgtgcgaggct

41641 gtgcacagct tgaagggtgg gggactgcct ggacctgccc ctgaagcccatcctgcaaag

41701 gagactcgcc ctgtgtaggc tctccagatg gccagccctg ctcattattagggagggagg

41761 aggggctggc atccgagtgc cggtgttggt agaggaattt cacatgagcagtctcctcac

41821 cactgtccgg tggaagtcgg agggctatag cagaaggagc caaaaccacactgctgccag

41881 gaggtggaat ctcccttggg tcctgctgag tgagcccaca tctgtctgactccagagccc

41941 aggctcctca ctgtctacac cgcttccctt tagggatgga attaatctgcatgtggacag

42001 ggcttggacc agggtaggaa gagtagggga tttgcctgga ggccaatcttgctcagcaca

42061 ctgtgtgatt aaggcagtgg ctgaatggac taccagtgac agccccatcactgtcaccac

42121 caccggagta tctagcaggg acttaaaagc acatgtcagg gaggttgtttcagggattcc

42181 tcctggaagg ggcgctggac aaggtctctc aggttcttcc caagtataagatctgagatt

42241 caggcaggtt aagcctagaa ggcaccagac gcctctgtga gcacttgcagggggaatagc

42301 tccaccctgc cccctgggag tgtcttgtca cattgcagca cctctgcggatcctggggag

42361 ctgccttggc tgttcttagg catctaattc tggagaaaga tgtgcctgatcgccccacgc

42421 tcaacaggtg ctcgacaggt cctaggggaa tcaaggcagc tgaatagccatccacaaagg

42481 gtaatagtag agcagggatt ctcaaagtgt ctccccagcc agcagcttcagcatcacctg

42541 gaaacttgtc agaaatacac attctcaggc cctctcccac ccactgaatcagagccctgg

42601 ggtcggggcc agtggtgtga actgaagtcc ggtggaccca gtttggtgacttcacattag

42661 aagcttgaag ttggccatgg cgggagtatt tatatctcag aaaccagcaaatgctacaga

42721 tgagcacctc tcctctccca ccagtgacac attttccagc atatccacagaagaggatat

42781 cccagccgtg catgttttca caagccctcc aggtgattct gctcatgctgaagtttgaga

42841 accactgatt tagaacaaaa aggggtgagg ctgcaaaaag atgagtgtattttttcgtgc

42901 ccgtggtcta ctgttagaat gtctacatgg tacggaagct aaaagtccccttccctcttc

42961 attttataaa gaccaaattg agactcaggg gcagcagctc cagggctcctggcccccagc

43021 ccagcacttc tgtctctggg gcactgcctg agctgggaga ggtgcatgcagctatggaag

43081 aaggcttcca tgggctgctc taagggccca gaagcccagt tcggctttagagtgaaggag

43141 tggcgtggtc agtttcatcc tcagggaggt ggggcacaat ggtggttggggctctgagct

43201 ccaaagggga gcatttcata tccattcctc atggctgccc ctaccacttcctcccctcac

43261 acagatggga agatttttaa aaaatcaatg ttcaccctcc acagacctcagggtggtaga

43321 gacatgaagc atgtctgagt cagaattcat ctgatacctc acctcacccagatctaccat

43381 taattagctg tgtcccttcc ccttccatgg cctcactgtc ttcctctataaatctcaggc

43441 agcatcagat gatgcccaag gtcccttcca gctctcacac gccctggatgcttccctccc

43501 ctttgtgcct tcagctagaa atggtgtgtg tattctaatc cactctatgtggaagcacca

43561 tgtaagaacg tctgtctgag ttccctgttc tctcccagag caacaaacagccttctgact

43621 gtggggtgca atggggttga agtcaactcc atcagcattt attgggcacccactgttgtt

43681 cattaattca gccagcagat attgagatct ctagtgtgct agaaatgtcaaacagaggct

43741 agaataaaaa gcaccaccca tgcccttgag aggttcacag tttagaggcagtacatgaat

43801 cacgacaaaa cggactgctt tggagtgctg gctgtgtgct gggggctttgacaagaacac

43861 tcgcagatga tctcattcag tcctccaaca acaactctgt gaagtagggcttatcagctc

43921 atcttatgag aaaaccgaca ctgagagagc ttaaggaagt tgcccaggaagcaggtagct

43981 tgctagtcag tgtcagagct gggttcagat ccctgtctct ttgatgccaggactgtgctg

44041 ttaaccaaag cattgcaccg cctctcccct gctgtgcagt tccatgggctctgccatcac

44101 acaggttcct gccatccagg aacttacagg ctgcagatgt ggaatggatgagtgagtgct

44161 gttggtgtgg gctggaaacc ttggtcatgg ttaggcgggt agaagccggaggagctactt

44221 gtccatccag gaaactcagg tcctttccca gcctccacac tgagcatctggaagcttctc

44281 tgcaagggct cagctaaagc tggatttcat gcacctttcc ccgcagtctgtagacatccc

44341 ctaagggtgc tcactgcccc ttggagctct cccaaggaaa tgggcctcccacaaacaacc

44401 atccacagtg ggacatgctg ccctggctgc aaccagtcct ggctcctgggccaccttctc

44461 cagcccagcc cagagctgga gcaagcccac ctgagtcctc cccaagcagtcacagccctt

44521 gggatgtcag tcttgctcct caccctggtc tcttccatgt taccaccgtgccccctctgc

44581 catccccagg ctcatcggga ccttccgcat ggtgctgcag aaggtggtagaggagagcca

44641 tgtggaggtg actgacacgc tgattgatga caacaatgct atcatcaaggtgggtatgcc

44701 ccacggagtt cctggacttt cccatatggg gccatctggg ggtctgttctccctgcctca

44761 cacatggggt ggtctgggga atgcctctca tgcatggcga ggtgtcgcaggaggaggaga

44821 ctcaggtcag actctgctgg aatggctcaa tctgtggcca tggctggaggccctgtggca

44881 tggcagggtc tgctgcccca cagtaggcac ccctgccctt cctacggtgggaatgcacca

44941 actggtcctt ccatttggac ccagctcagg agtcactaaa gaggctccttttgtcatcca

45001 aaggccagac tgagccctgc tggcactcga gggcatgacc ttcactctgcacatctggct

45061 cgggtcctcc ctgggagggc agggacctca tttcctattg tttgtcacatcccagcactt

45121 ttgcgtgagc acgcgtgcac tagtgatgca cagtctagag gcacctgacacatgttctaa

45181 caaagaagga agcaacccta ccaggacagc ctggccccag gctctgctctgattcttcag

45241 tcctcttgag ctcagccgtg gccactcatg ggcagttggc atgatggtgaggaacaggga

45301 ccctgagtat gaatcttagg ctgctcacta actgtgtgac ttaggcaagctacatatcac

45361 ctcaaagtga gcacaattac attatccacc tcccaggact attctgaggattaaaggaca

45421 atacacagaa agtacttagc acagatatgc acaataaatc tataatattgttagctatta

45481 tttcctgacc tcagtttacc tatgtataaa atgggactgt gccatggtcccccagtgggg

45541 tcctgtgtaa tatatggccc tatgtagtgg ccaagagaaa cagcctcagaagccaggact

45601 gcagccacag ggagctagaa cagaaggaac cctcttctcc catgggcaggggtggcaggg

45661 agggcttctt aaagttaccg gggtctcagc caccacagca aggggagaaggggtgcagaa

45721 taagctatgt atggacaccc atgggaaggc gggctgggag gagaacacagaaacctggat

45781 gaagagtgta gtgtgggaag tgagataaga gaattgggga gtgagcagggatggacagac

45841 agcacagccc atgccctgga ttttcagaat cagacttaag atgtcagcagaggaaaggac

45901 tcacggatct cctagcccac ttgccaccca tctccgctac ccattgttatgaatgggaac

45961 aatgaagtcc tggatgggga atggattcgg ccacagttga cagcagggccagcacggaga

46021 cccaggactt ccaatgccag agaccaccat tttcccataa caacatacttggttccacca

46081 agagggtccc atttgttcca gaaaggacat ggggcttgga gttaggcagcctgggctcag

46141 atcccagctc cagtacttcc tagctgtgtg acttaaagca agtaacttaacctcctgata

46201 tgctaggtaa ggtaggttgc aatgttgaaa agatcaaatg agtgtacattaaagcatctt

46261 agcatgatgc ctagcacagt gaggattcag aaaatatgtg cacctttcccttcccttggg

46321 aaatctaagc ctgggtgctg gagcatccaa gcactgagtg agggccgcctgtctggggca

46381 caggaccaag tcacctctag accagtgagg aagggtgatc cctgtgcactgggggggaaa

46441 ctagagctgc aagaaagtaa tggctccagg acgcagagca ggaagcccaatcatgactct

46501 ccactgctaa gcctgagccc ggttgagtgc tctacttttt gccagaggaaaaccctaggg

46561 cagctcccaa gattccctcc ctctccaggg taggaagggt gagtgtgagcctgggccctg

46621 ggctcctctc ccggaggcca ctttcagctc attctgtcca tttccaacaagccgatttct

46681 ggcgggccgc gcctcatgcc tgcaggcagc ccttgttctg aggagaggaggtggcctgat

46741 catggggatg ctgaacgaca ctctcggtta tgtagacagt ggactcggggggtgagtcca

46801 ggctcagttg tcctgggcag gccaggcccc tccaccttga gcaccagggaggagtggaac

46861 caccagcagc gggacctgga gccaggtacc agtaagctga cccggtctgcacaagtcagc

46921 ctttcagagc ctctgttttc tcatcagcaa aatggggcag aggggatcataccatcctga

46981 cctcctccag tgaggcaagg gtgtggaagc gctgtgtaaa caccaccaagcagccacata

47041 tacggggtgg agattgctgt caccatccca gctgctcacc accgcctccctcccttcaga

47101 ccagcctgtg cgtggaggtc cggtatcagg ccactgacgg cacagtgggctcctgggacg

47161 atggggactt cctgggagat gagtctcttc aagaggaaga gaaggacagccaagagacgg

47221 atggactgct cccaggctcc cggcccagct cccggccccc aggagagaagagcttccgga

47281 ggtaacaggc aggacccctc tggctgccca ctgctcccaa gacacggggaagagacctgg

47341 ggcctggtcc tactgacagg cctctctagg cctagctggg ctcagagtacagggctgagc

47401 ttctggagag acatccaagg ggtgggaaga tgtttctgta gccccccacccagccgtcca

47461 cccccgaggt cactgggcag ggagcaggag actcagatgg agctgcaaggccaaggcctc

47521 cccagtggcc ctgagggagg tggagctcta acacagggat ggggctagatctcctgcctt

47581 tctcagagaa ggggagttgg ggataggagg gcccctggcc tctctggttcaagacccagc

47641 agtgtccacc aggtgccggc agcctgacct ctaccctggc ccagtgaggaggcccaagag

47701 agggcagctc ttcctgccag agtgaagcca aagatcctgg ctgggccctggcctttcttc

47761 ctcttgagaa gggagggtac ccgggaaccc ccagaatcca gcgtcacgccctgcaagtgt

47821 cctgccacct atggatcaca ggaagctgga tccaggacag ctcattccacgtgcactatt

47881 tttacaaaac agaaaatgca attgtattac tattagagac caaggggacagaatctgggc

47941 tagtctagta agatgttgtc catgggttcc taagtcacta ggaattatgtgttaaatgcc

48001 agtaagtcaa gggtgcatct gaaggaccag ggtgtgtttt gagaagggaccctccgtgcc

48061 actggaaaca tatccctgta agctccttcc acgctttcct ttccaagtaaagtttactca

48121 gtccctctgc tgaagaaacc ataggttcta aattagtgta attgaactgacatactttta

48181 tgggacaaat atgttttctc ctttgcactt gaatgagttc acacccccttaagcacccct

48241 cacacacagg tgcatgagtg cacacgtgtg cacatacaca tacacacacacacacaagct

48301 tcagaaaccc tgggagccag atgagtaata gtaacaaggt caaagtgaccaggcctgcaa

48361 caaacatggc gggactgtct actccaggcc agccacgggc atggggcagccccaggctag

48421 cttaaagcct gtcccctcag actcctggct ctttagcaga aaacccaggcctgagtccta

48481 gctctgcctc ttactagtcg tgtgaccctt ggcaagtctc tgaccctctctcctcacctg

48541 caaagaagga catagcaagg aaatccccct gccctgctgc tgggagagccggagggatca

48601 cagaggaaca ggtggcaatg gaggtgctga gcgctgccca tgtccaggctggtgacagac

48661 aaacaggttt cttgtagcac aacaatgcaa agagtcagga atcgggttggaaattgtgag

48721 aagaggagca gtgctcagac ggggagtgaa gggatgctga ctcagtgggcaccacctggt

48781 cctcctcgac tgtctccatt cagaaaagag gttggcaggg ctggtccagaaaccagaagc

48841 cgggctctaa gaaagagctt ccagagaaca agatcggaag ccacacaagggccatcagtc

48901 acagggaaag gaatgctgac cccaaatcag gagagctaag gcccattaagtcccatcttg

48961 actgtgccac tcattggctg agtgacactg ggcatgtcac cagcccctgtaggtcagtga

49021 caggaatggg ttcagcaagt tacatctggc tcccctccaa ctctgaggtcctaagggacc

49081 catggatgct ccggacctgt gggtcacatc catgggaaac aacatcctgggagcccttag

49141 cagccacgaa ggcaacctcc ctggggtggc gtagcaacac agagccagtttctcactcag

49201 tcctaagaga gtgggccagg gtgctgatgg gggctctgga gagcttagagtcccagagag

49261 ccctaggcac caggaatctg gagataagag ggctcccccg acccttcctcacagcctggt

49321 ggcttcccca cctctcccca tcttcgtgtg gcccctccca gggtagcagcaagaagcggg

49381 agcaaaagga ggggcttcac cccggactgg gaattgggag agggtgacagccgaagccag

49441 gcacccccac cctgcattgc aggggcagtg tgcaggagca cagtttccctgctgccactg

49501 gggctgccag cccaggtttg agagcacatt ggggacaggc atcgctgctacaccttctcc

49561 cgccaggcct agccatgcag ccagcaggcc tggttgtgga aaagaggggttgagaaaaat

49621 tctagagatg ggccatttgc tggtgaggag aaggtggagc gggttcaagaacttggggtt

49681 ttcctgtagc ttaatcctgg ctgcccatat ggggccattg agttctgggtcaaggagtgc

49741 tgaggtgagg agggggacct ggaagctggc cccgcagccc tagatgttgcatctcaccct

49801 tgtcacatag tgtgggttct gggaggaagc cagagagctc tccagaagggacttggccaa

49861 ccttttatca ggaaaacacc tactccttaa agaggacaac accggggaaggggtgtcagt

49921 gcctcacctc tgaccccgtt aggagcccag gcaggcttcc cctgcatctgctccctgccc

49981 tccatcctct cctgggaagg ccaatcccct tatagatcag ggtattcaataaccacagtt

50041 ccctcttgtt cctgctttag ccacaatgag caagaggaaa atcccgttgctggcaagcag

50101 cagtgtctca ccggccatct tgaccgttag ggtccggcgt ggggatcagccgctccctgg

50161 ctgatggggt gaaatgaagg cctgctgggg gctgcgggga ggtagactgagtgggcagga

50221 aacagcctca gcccagacag gccccgggca gcccaggctg gaatcttccacggatggagg

50281 ggaggctgat gccaggagat cctctgggca ctcctcacct ctccctccagggcctgggtc

50341 caccccccag ccctgccctg cctggcctgc ttctctggga cttcacccacattcatcctg

50401 tcctcactct gggggtcaga tggttctaag caggggcagt gtggacctcaggcctcagct

50461 gctgtgacac tcactcctaa gaccctaaga atctgccatg aagttaccccgttcctcctc

50521 agggaatcag tatgggggct ctgcctgaat gaccaccaac cccaccgcccactgactctc

50581 tgccccaacg attccacctc ccctaggccc tggtcagccg catgccctctgagccactct

50641 gcccacttct ctagttcctg ccacgaagcc ctgatttctg ccggctttttgcacaatgcc

50701 cccggtaatg tgccaggaag ctgtgctgtg tgacagagca caggctccactcacagctct

50761 gctattggga acccccctcc ccatttgtga gatggggctc aaggatgcctcacagaagtg

50821 ccaggattga gtgaggtgca cctgcgagtc atccacccct gtgcctggcatgtggcaggt

50881 gctcagccag tgttcacttc cttcctcttc actgactcca tgttaccctgatgtcaactt

50941 ctaccccgag cagcacctga ccctcttgtt caggtgctgt ccaagcaccttctcagctct

51001 tgctccccac cctataccaa gggctctgca gaagctgccc acacaggagccttactggcc

51061 caggggcagg tatagggagc tcatttactc aaagttcccc tcacctccccaggctctcag

51121 tgttgcagag atgtaatgaa tccctaacct catgggcgct ccactctcagcagcacaaaa

51181 tcagtgttcc agacccttgc atggcagcgt atgcctgccc tagtctctggagagaaagtg

51241 acttcggccc tgaccacact cacatgcaca cacatgtgta cacaagtgcccatgtgtttg

51301 cacacactca catgcactgc atgacaccag ggaggactct ggattctgggctctgctgtt

51361 gatgctgtct ttaggagtca catcttagag aggacaaaga aagaaatcccagctttagtc

51421 ttgcagctaa actgtagaga cctgagcctt tcctcctgag tcccagtattctgcgactat

51481 ctcctcttct cattttctcc acctggcctg gctctcctgc cctccacgacccccacctcc

51541 ttctgctgcc caaaccctct tctgctggtc tcctctctgc tgggtctcatctgggaggag

51601 tttggggcag gagccacttt tctcattctc cttattgatc attcttccactccagtggag

51661 gcctgcagaa gccaggtaac ttcctcctat gctggggcca gagggcagtggggcacgtgt

51721 gcatggtggg gctctgagac agaggggcag agagtgggca tgcagaagtgtgtgcatgtg

51781 gggccagtac atgcagcctt accccaagag tgtttttaaa tcggtttccacagcccctag

51841 agagctagaa aatcctctgc tgccttcctt ctccaggctg agccccagagttgcagcagc

51901 tcccaaagct gctcagatga gccggggcag ccgggcgcac tgggattttgtgcttgagac

51961 acattcctcc tcctatgctg tgagctcttc tccgcttagt agtctcagctgatgtgggca

52021 gccgaggcct ggctgatgtt aacacctttg aattacagac tgacctgcttgcccaacgta

52081 aaggttagct ggccagcgct ggactgcagc tgtgctgtgt ctaggccttcaggtcttgag

52141 ccatcaggat atgcagtcaa gtctacctgg gcaaggcctg tgccagaacagggtgtgagg

52201 agaggaataa tttgctaatt gttattcact ttcctgtctt catcctcattgccacagcac

52261 tgggaaagca ttgagagaac attccagaaa agttttctgg aagcctccctaaagtgagat

52321 aggggggccg tttttccctg ctctgagccc tggagtggta gctcacttaccgccccacct

52381 acacccctag aactgccccc aaccacccgt gtgcactcca tagcaggacccccagccctg

52441 cctcaccctc acagagcagg cttagcccac tgttccccta gaggcccccagagcctggga

52501 gctcccaccc cattggaggg gagcagggga gcaggggagc cggtgggcagaggagcaggg

52561 tggcccaggc cgggagggtg gccaggctca tctaaccctg tgttccctgaggaagctgcg

52621 acccacattg tggaatcatc agatcttagc ctggtagggg cgatgagctgaggccctgag

52681 gtatcagagc ttggggttgg aatagtggcc acccaggccc agcactgtgggcccctccca

52741 tctcccccaa ggcagaaccc agggccatgg gacccctttt ctgcagacctaggcttgcta

52801 ccgtgcgaag ctgtggggtg agaggtctgt gggacaagga ggcccccggggagcgtgcag

52861 gcccgtgggg ccggggctga ggccagtgtc tctggtccac agcccctcacacgtgtcccc

52921 ttgtctcctc atttcttccc cctactcagc aaaggcagag agaagaccaagggaggcaga

52981 gatgacgagc acaagtaggt gtcccaggcg agggcagacg caacagcgtctctggggaga

53041 cagaggcctc ctccccacag gctgtggagg gcgggatggg ctcggctgagagggctcagg

53101 agtgggctgt cgtggtagag ctggcacggg tcatggaggc ccagggaggccttttcacct

53161 ggccacgggg gtgagggatg aggaggggtt agggtcgcgg gggaggtggccagaccttct

53221 ggtttccact ctgggctctc gggggtgacc atcctcctct ccgtgtcttgttcctcctcc

53281 actgttcagc ccccatcctg tggccttcgg gcttccctgg gagggaggggacagctaaag

53341 gctaagggga gaggggcatg aggacctcag ggatccctct cccaacaggggcgaggtagg

53401 gccaggcagc tggaggcata aggaggagga actctgggta ccctttgcagctgcaggtcg

53461 tgggtggagt tggagacccc cagaaagctt aggagaggcc accatttgggcggccctctc

53521 tatcttcatc tccccaaaag gcttcctgga aaaatgaggt cagggtgctgtctggagagg

53581 acaggagaag ggtcctgcag gtgggagggg ctggtcacaa gggtctggaaagattcgaag

53641 gctgggagtt gtgaatgggt cttgtaggca cccctagaag cacactgacatctggaggac

53701 tctagcatta cgggatctca taagggcagt ggtagccaag gtggaccatactggaggagg

53761 cctctggtta acacctgctc ttacagatga caaatctgtc tcagaacaggggcagagctg

53821 gaaccagaag acagggaagc tgacttctga cccagagctc accatagacccaggaaattt

53881 agagaacttg actgtatcta aatttaatct aattctccaa acataccaatgagagctgaa

53941 aagccaggag tgtggtcttt tttatcttcc agataagcaa cctgagccccagagatctta

54001 agagatttgc tcaaaactgt ggcctcaata tattaagaat tagttcatctgaagatatca

54061 tggaaatatc aggattgtgt gttgaggggt ctgaactgat caacactggtgtgggcttgg

54121 gatatccact ggcattaaga tcctggggaa ctcacagcct cattcattgcttcaaaaaaa

54181 ggtatgagtt ctaactcgca tttgttacgc acaagcaaaa gcaatgatgatgcagtgtta

54241 actctgtagt gatggaggaa atggcgctgt gtaggaagag ctccagcccagagacctgaa

54301 ggatggagga gtttgccagg ttcccagtaa gggaagacac gtaggcagagcatgtgtcaa

54361 ggctcagagc cagggaactg aatccagggt gggtggcgat gatggggaatgctgagctgg

54421 ggagtcctct tagggagtcc tcaagggttc aggtttctcc atagatgcttagatgtaaag

54481 ggcatatgaa tgagatacaa gcagcctgtc catccccagc ttctctgcctgagatcagcg

54541 atgctctaag gcccttcttg atgcccagct tcccagtctg tcccaggccagacccacagg

54601 gacacagact ggcctgatcc ctttgactgg ctacagttgg agtaagaggtacctcacagt

54661 gccagcacat agtaggtcca ccaaaatact ggtttcctag cacttctctgtcctaatttc

54721 ttaccatctc taattagcac atgagataaa gtaaactggc atatagtattgttattatta

54781 ttatgtgtag agcaatagga ctattgaaag aataggaaaa tgagatttctaagaagagat

54841 tgaacaaatt taaactcttt agcctggagg agagaaaact gtggagacagatttcaatct

54901 ctgaaatgtt aatgtgtggc aaagctggtt ggtatctatc tccactgagaagagataaat

54961 ggaaataaat ttaagttgaa gttaagttga agtagagaaa caagattcaacccacgaaag

55021 aactcatagt gtgtgacatt ctgggatagg ctggtttggg gagatgagaaaacacccatc

55081 atcttccatg atgctgcttg cttgagcctt gcaaagggct gggccgccagcaagaactga

55141 agagccagct tccctgacaa tcctggggtc aggacaagtg tgtgtgggtcccccaagcct

55201 tctggtacaa cgtgggcaca tgtgcaaacg ggccagtttg gagacagggtggttcttgta

55261 taaagggtca gcctatcctg cccacctatg gaaagctatt caaaaactaactgacattca

55321 acacactttc aaagacacct gtaaagacca aaattatgaa attccctgtgccttggggca

55381 tggaaaattt ttaaaataaa cccatttagg ggcgcttgga taacatgctccgaggttttg

55441 aaaattgggc tgtttgagca atgcaaagaa ggaccacaga ccctatttctcatagacagg

55501 agtctttatc ctgattgatt acctgaggcc tgagctaatg agcctagtagttccagttga

55561 agccagtcat ggggcagaag ccctgggcag tgaatggact cgacctgcagctcatttatg

55621 gtcaggtctc tattagcttt cagaataatc cagagacctg aattaatgaaacactcgggt

55681 cactaaattt agtttggtga atgttcccaa gtcattatga atactaagctctacctagga

55741 ccctgtgtgc accacacagc aacacgcttc taaatctggg ccataaaatgagcggagaaa

55801 tcatcagatt tatagtttac aataagtgaa ctaattttag catttttttcctctagagat

55861 aaataccagt ctagattgta ggtgcatttc attctgacca tggtgaatgtagccacagga

55921 aactcaaacg gattctaaat cctcagaggg tcctgggata ctggcctccccttggctctc

55981 acttctcaag ctttaatacg cccaagaata aggagccatt tgattgtaaagtgagttttc

56041 actgagttga ttattggctt gttttctttg tctgtttctc accatatcctgtttttggta

56101 attgtagaac tcaactagac caaatgcaga attttacttt gaaaacaaaaaaaggccagg

56161 acaacggaca cctcaacagc aaattacatt ttttgaaatc taagtctttcagacaaatag

56221 ataatcttca aaattccctg attaagttga catttatttc aaaactctcctttacagttt

56281 gccaagagaa gtaggcatac tgctttctgg gaactggtgc tgcaatcaggcagaaaggct

56341 ttttctatag tgaacttctg atgtgttact gatcagaaaa ttacaaaggctagtggcagt

56401 gatgacatca tgctgtactg atcacaattc agattcattg aagagcaagtctaggagaat

56461 cagaggtaca gagcctgtag taagaattct ggaaattaca tccttcactacacatttctg

56521 catttttaat aaagggacaa agacaatatc cttttgagat attcccaggcacacaggagt

56581 gctaccagta ctaccacttc agacagctaa aactatgcag ggttggaagggagagatttc

56641 tcctttcaat tgcttcaagg tgtagtagag atagttggac aagtatagtttttgtttgtg

56701 tgtttgtttg agacagagtc tcactctgtc gcccaggctg gagtgcagtggtgcgatcgt

56761 ggctcactgc aacctccgcc tcctagttca agcgattctc ctgcctcagcctcccgagta

56821 actgggatta caggcatgtg ccaccacacc cagctaattt tagtagagacggggtttcac

56881 catgttgacc aggctggtct tgaactcctg acctcaagtg atccacctgcctcggcctcc

56941 caaagtgctg ggattacagg tgtgagtcac cgcaccggac caggacaagtatagtttttt

57001 aaagcctcaa tcatttcttt caaatctgtt tgtgttaaga aataaagtgactttcaaatt

57061 caagggccat aagtgcccca gggatgcctc aggtcctttt ccacctgggtgagtccatgg

57121 gaccagcctc tgaaagccac tatttcttgc taccttgcac tccccccgggactcaggcag

57181 cagggccaga tcccatccca gcaggccggg cagccggctt ctccaggcagggcctgcttc

57241 taacctacca tctcagagca cttcccctct ggggaagtggggaaggggcaggggagaggg

57301 aagtctgtgg ctggagcagg ctgcaatggc aaaggctaac tatgtaggtcacacatgcgg

57361 aagggccaag gactccaaga ataacacagc ctaggaatgg ccaagaagtaatggtgcaaa

57421 gtcaaacgct gagccctgca ggagactcct gggtaattca ggagagacatagttgagcag

57481 cacggctggg caaaaaggaa tcccaagcac tgagacagga agtgacccacgaggaggccc

57541 acaaaaacta cacttctgaa gctgggccta tggcaggggt caggacagccagcacccctg

57601 tccttggggc cagcaggtgg ggcaaaatcc cacaggatgc ttcagggcaagccagccagg

57661 gtggtccttt ccccaccatc acacgattat ttctggtggg ttcattgatctgttcaatgt

57721 tatgtcacca gcaatttaac atgcacagca gtcccttccc aaatgtttgggtgctcaggt

57781 tctttttgaa tgagcccctt ctttgtaaac atgggtatga tctgtgagattccacagatg

57841 acagcatcct gatctgtaaa ctatgctggc acacagacca tacctgtacctatgggtgcc

57901 agccctgggg ccttttagct aaaatcccaa atggtcagga atggatgggattcttgccca

57961 cagaaaagtg cagtcctacg gcatcgaggc aaaggacctg agatgcagtaaaaatattgc

58021 tggcctagaa cacaggagct ttctgcttca atcccagttc tgccactcaccgtgtgacct

58081 cgcgattatt gtcccctctc tgagcctcag tctttttatt ggttgaatgaggagaagtat

58141 gtggccctca gaggattgcc aggaagatga aatgagcaga catctgcagacattgcagac

58201 atctagaaag gcctttggcc ctatgtagtc tctttttggc ctgtatgtgtgtgtgtgtgt

58261 gtctgtgtgt gtgtgtgtgt gtgtgtaact cacctccccc atcagaagggaggaagcttt

58321 tgaaaataat tccaaaggca tcagctttga ttttagagcc tctttctttccctttcttct

58381 cattgtcgta tttcagatgg tatgctactg aagagtgcag acacatcagccttcttccat

58441 tcctttttag gaattcaaag aacatgctaa tgttccctaa attgtgagctgctgccacgt

58501 gaaaagggtg attctcaatt gctccctcac tgggatatga acgtgctttgtcctgcatat

58561 gaacagtaaa gaaaggtcct ggggttggga tagggccagg tttggggaataagattggcc

58621 ccacaatcct gaggagaggg gcttgaggtt tctaggtcat ctgcctgaggacagaaaggt

58681 tttccccaac ctcctattgc ccagcataaa gaacaaggat ctggggtcttagaaaccata

58741 gtcaagcctc cacagggaga tgtgtgaccc aaaaagggtg gactctgctgtaagcgagct

58801 ccaggttgga gcctacacct ggctccacct ggacctacag gatgatggggccatacccag

58861 gaggagggag aacgggaagt ggagagagtc aggtatccac tcatgcaatatggatggggt

58921 aatggaacac tgcactttac cctctgctga tcctgctcct ggggcttcctggtgccagga

58981 accacaggct cggctgcagg gacatcactg aaggacagtg aggacccctgccccttttcc

59041 tcagccccgc tgactgcaag gcccttcacc tgggggcaca aggtcgcagcaagccagagg

59101 aagaggtagg aactatggag cctgccataa gttcctgggg ttgggggaaaggggaatttg

59161 gcagtgagag gggacaggta gaaggggcaa aatccaggac cgaagatagatgggaaaggg

59221 cctatctccc cctttttcat ggggaccaag gagcatccca gaacacggagaggttggaga

59281 aagacaagtc aggctttgag caccagggcc atctgagaac tgaacagctcgtttcaacca

59341 catctcccat ctcctcatcg gcctctgccc ctgagtcctc tctggtccctgccccgccgt

59401 tctgatgctc tgtctccagt cctcgggctt tctctccaac cagctgagccggggaggatg

59461 agcgtgggga cactggcagg gctcggagct ctgaggagac tagactgaggggctgggatc

59521 agactgaaaa gtccaagacc cagaggagct ccagttaaaa cggctctttccggctcaaga

59581 ccacgttccc tgcttgctgg ggaccccatc cctctcctcc gtgtgtgaaaggatggcaaa

59641 ggcggaagtg gaggggtctc tcactgccct gattccccct cctggctcccaatttgggaa

59701 gacagatccc gatctgtctc gggaccagta ggtgaggggc cgggtccatctcccttctct

59761 gatgtgttct ctcatgtttg gctcttctgt gtttgtgtgt tttcctccatgcgtccctct

59821 ccctgcacct cattctggtg gcccccctca cagagccggg aggagcgtgttctccgccat

59881 gaagctcggc aaaaaccggt ctcacaagga ggagccccaa agaccaggtaggacaggtgc

59941 cgcgtgagcc ccgcagcccc gcgcctcgcg gcgccctccc gccgctttccagcccctgcc

60001 cggctgccaa aaggccctcc tgggataggt cgtcccaggg ccaggccccacccagtgatg

60061 cgtggccctc taggaaggag acgccctagg gccgagggag ggaaacgggcagcgccctct

60121 gtcgggggtg cctggttaca aggctcctcc cgccctcgtt gctcccggttcttccttctt

60181 cacgcagaag cccagtgttt taattagagc agagaatatc catcaagaaacgctgtttgg

60241 ccaactccct atttctgggg ggaaaccgtt gtcccactag tacggggtcggcggcaggcc

60301 tcgcccaagc gctctcacca ggctgcagcc tggcctttgg ggaggtcctggggccgctgg

60361 agggcgcggc agggccgggc ctgggaggct ggagcagcag gtggcactgggccctcccgg

60421 aggagcgact ggagagggga agacagctgc tgcagaggag gcgggaggcctggaggaaga

60481 caaggggaga aatggagagg acaggggagc tgggaggggg ccatcttctccatcacgggc

60541 ccaccatcgg ggctcccggc tgccctcccc cagcatcccc tctgtggcctactggccctc

60601 aggctctctc ccccaccctc ttgcccccat gccaattcca gccgtgcccttcaccttctt

60661 aaatggagag agtacagctg ctggctgagg accaaaccca gcatccttgggtggctgttc

60721 ggaatccaca tgtctgcatc tcattagatg aatacacacc aatgcattaggttctgaatt

60781 ccatcagctg tttgatatgg ataagttact tcctaagcct tcgtttctgtacctgtgaca

60841 tgagaataac gcccatcttg gcagggcaca gctctaagga ctagagatagtcatgtaaag

60901 tcctggtgtt gtgcctggaa cagagagtat ccacccaaca aatggtagctatttattgag

60961 aggtgcaaaa gtatggattc tttattccct accttcttcc ataagagatattcagtgcct

61021 aagtaagtgg tatacaataa aagagcattc aattaaaata aaaaggcaagaccagacata

61081 atggccattc aaatccaaga tcgggattag gtagaaaaac actgcagttattcaggccat

61141 aatattctaa gcggtagcaa ctaagtaaac ctcgaattta actctcagctttctggatgc

61201 cagagtaaaa ggagaaatgg tcactatctc accatcagtc agcccacctaaccagtcttt

61261 catcttcccc agatgaaccg gcggtgctgg agatggaaga ccttgaccatctggccattc

61321 ggctaggaga tggactggat cccgactcgg tgtctctagc ctcagtcacagctctcacca

61381 ctaatgtctc caacaagcgg tgagtggacg ggagccctgc aaccccagctgcccccaccc

61441 tgtcaggcag gacctggctt gccatgattg gaatttgggt agggaagaatcagggctcat

61501 ggacggcttc ttcctaacct aaccttaccc ttttctgctt ttccttgggtgtttttctca

61561 cctctctccc tgcaaaagca gagcacagca gctgcaggcc tgttctcaggtccttgaata

61621 cctcccagcc caaggaagcc acagacctgc ccaccccata tttgaacctattgaccccat

61681 gtctgtctct ctgttacttc tgcctttgat tagttctctg tgttgaggcctctgaagaca

61741 actaatcctc actattcttg gcagtgcttg agtgtttaaa gaccatgattctgtccctct

61801 gcccactccc aggtctaacc actgccagtg tcctcctccc caacaagcagtccccatacc

61861 ccaggcctga tggtacattc tcttcctcag atctaagcca gacattaagatggagccaag

61921 tgctgggcgg cccatggatt accaggtagg tgggcacctg gaggcctcatgtctttcaga

61981 ctctgctcta gtgggggatt ctagccggat gtgcattatc cactatactgaggcatggat

62041 ccaggggtca tagagaacaa caagctgaat ataagttccc aaagtaagcttgttcctggg

62101 aggcattcct agaagtatca tcagtagaga gatacaaacc caaagaaaagcttgagaact

62161 ctgcctatgc taatcaaagc ccttccagta tttcatgttc agtattggacttcataaagt

62221 gagaagcacc tagaaaaacc ataaagagac caagaactac aaaaaagtattcaaacagtt

62281 aaaataaggg cctttgaaga aagttttcct ggcatgattt ttaaattgttgttttgtatt

62341 atttgattgc tggaagtaat gacgattctg tttatctctg gatggtgagactgtgagtga

62401 tttttttctt ctttttgctt ctctgtattt tctgagatta acacaacttttttatttgtg

62461 tgcttctaag accagagaca aaagactgag acaaagagag gttgacagctgtaagaatgt

62521 gaatgtggcc aacagtgcag gcaggacagg tgatgagcat gtctggtggctgctgggaca

62581 ccatctctca ggaagggccc agggaccctc cattgctcca gaccctcccttggaggctaa

62641 caggactcag ctataaatca gaagactgct gggctttcct aggattgagttagaatgctg

62701 gctgctcaga ggggacaggg cttgcaagag atctcacctg gctgccactgcacttctgtc

62761 ctggggatgt tcggtctggg tatcagcacc aggccccaga atcagagtgagccccatcta

62821 ccagggtaga gctttatctc tgatgcctag ttccagaccc caagcacactaacccttctt

62881 tacggacaac cccacctccc ctcactcagg tgatgatgga aaggataagatggcactttt

62941 ctatgtaaaa ggtacatctg gccatgtttt ctccagaata tacttcatctcccttcatct

63001 ttgttttagt tagtttccat ctactcaggc aactgtcttc ccaggtgcctgaaaaacagc

63061 cccaggcaat gtcaaacgga cctgcccctg tggttttaaa taacttcaagccattggatt

63121 ccttaggggt ttgagaatgc cggcccctca cctctgccaa aacccaaacacaaagtgtcc

63181 tgagacttcc gagggctttt ccaagggatt gggctcaggg ctttgtttctctgtgtgctg

63241 agaactggag aattccaaag aacaacgacc ccaactcagg tatcatgtcactggcctaag

63301 aggtaaggac acatcaaaaa tagagtcatt attgttcatg aaacttatttttgaaggttt

63361 attctatgcc aggcactgtg ctaggagcta tatatgtatt tccattgaagttaatgtaat

63421 tcttcaacca cccaaatata ggtgttactg catttatagg taagaaagtgaggccccagg

63481 aaggtcagga acttgtccca ggtcgttgcc actaagttag ccaaggttagagccagggtt

63541 caaggccagg ggtgtctggc catagccata agagcaattg acttctctatatcaagcctt

63601 ctagacagct gctcccttcg ggtccctggt tcatcttcat cttgctacttagtgcttgtt

63661 ttccaaacct tttcaaactg cctcctacca gagactttta ttaactggaccagacattgt

63721 cccctccaaa gactttttaa accgaactga acaaaacggt tgttgtatttaacctggtag

63781 catagtgttt cccgacaagt tcattcacaa ttaaccttgc aaacatttgagtgagagcta

63841 tgaggatgca aatgtgaaat tattttcact tccaatacat acagtgtataatgcaataaa

63901 agcaggccgg gtgcagtgac tcatgcctgt aatcccagca ctttcagaggccgagatgag

63961 tggattgcaa gaccagcctg gccaacatgg tgaaaccccg tctctactaaaaatacaaaa

64021 attagccagg catggtggtg gcgcatacct gtaatcccag ctacttgggaggctgaggca

64081 ggagaatcac ttgaacccag aaagtggagg ttgtagtgag tcgagaccgcaccactgcac

64141 tccaacctgg gcaacagagg gagaccttgt ctcaaaagaa aattaaaaataaataaataa

64201 ataataaaaa gcaataaaac cagatacgac ttcactctct tggagactttgggtttgatg

64261 agatataaag accgcaggaa ggacacctcg ttggtgagat gtggggagacttagctgaac

64321 tcagatccag gaagggttgt gagggctcag gaccattcta aaggttatggcactgaaaga

64381 agcctggagg taaaaggacc gcggcgtacc catgctcttt gtttcttccatttagaatgc

64441 acgtcacgtg taaactcttt cctgattatt gccatctcca aggcaagaaaccacagtcac

64501 ccccctgtga atgtgcagtt tccccaccag agtgagcaac gcttggcacttggcagagat

64561 gttcttggtg gatcaagggg tcttgagtct ctttattacc atctcttcctggcaccaaga

64621 cttaatacat tgtcacccaa catctctcca gttttcacct ccatttcatgcccctgccac

64681 tgacctgagg tccccagcct caactgcatg gttgtaccta ctttctacctggtctccctg

64741 ccctcatatt gcctcctcca ctccaaactc catgccacca ctggagcaaacttctgaaaa

64801 tgcaaatctg gtcatgtcac atctctgcca cctggaaaag tggggagtgggtaatggatg

64861 ttgcagaagg acagtactaa agggcgcacc aactctcatc tctggctcccagcagatgtt

64921 cctgaagctg gatcaggtcc ctgggaagca ggtcacaaag cattattactctcgggtttt

64981 cccaggacag gggtatagat ttaccactca gcattattcc ttgtgatcgctttcatgaag

65041 ccactgggga gtatgtccct tatcttgaaa ggagatggtg gaatagtcagctggtcagtt

65101 ggtcccagct gtggctccgt ttgcctcttc atcttccacc ctggaaaaattgagtcctct

65161 gctgatgatt ggagagaagg atggccaagc ccctccccca gaaccctggagaatgaccag

65221 ccatttttta ttttttattt caagtgcatc atttcccctt cctagagccccaggaggggt

65281 gggaggcagc aggaatggca ttccccttcc cccaacacca tgcgcctggtggtctttctc

65341 cagcgccctc agcttcctct cggggctgcc cttcaaccag caatgagcaccctctggagc

65401 ttctcttccc tccgttgctc cttcaagcct ctgcccacct tcccctccaccctccgcctc

65461 tactgccaga gcttctgccc aggttgtcac cttcactggc tctgctacatggaggaaggg

65521 agaaacgtat gaggcctgaa aagggggaca gggagaagta gcctgtcttatggccatgcc

65581 tcgagatgga aaacataaaa accaaccact ctcttggcag tgggaagaggacttgctgct

65641 ggcttatctt cggtagatgc caaaactatg tctgtccgct tcccagtcctgagttataga

65701 aagccttttt tattgttggt gggggcatta gttgtggaaa aattcatggggtttttaaaa

65761 atctttggca aaaaagggtt cgtggaagtt aaaactctac aaactattgtgcaaagaagg

65821 acttctagtg tccgtttgct ctcttcatag taaacttctc agagctaagttagttagtcc

65881 tatttccttt ttagctccct gaaggagcag tgaatattga acttctgtgaagctccagat

65941 tctaagcttt tacttccgtc cctttgtcac ttcacgttcc aaacggaaatgtttgcttcc

66001 tagttcaagt gtcacttcat ttgtaaatat cccctttcct ggcaatgttctcattaacat

66061 tggaatttct atttccttaa catgattact tctgatgtgt agatttttaatcaccctcag

66121 gttatttttc agactttgat ggacactgga tgatcatttt agtggttattctttttcatg

66181 gaaagggaag ataattctct caagtaaagt cgtatttaga agttgcatcaaagcacaact

66241 aaaatatgaa atctccaaga tgacaggcat gaaaagcaac cttcggagtcgcattagaag

66301 aatgtgccgg gctcagtggc tcacgcctgt aattccagca ctttgggaagccaaggcagg

66361 tggatcacga gggagactga gaccatcccg gccaacatgg tgaaacctcgtctctactaa

66421 aaatacaaaa attagccgtg cggtggcagg cgcctataat cccagctactcgggaggctg

66481 agtctggaga atagcttgaa cccgggaggt ggaggttgca gtgagcctagatcgtgccac

66541 tgcactccag ccggggcaac agagtgagac tctgtctcaa aaaaaaaaaaaaaaaaaaaa

66601 aaaaaaaaag aagaatgtac agaggtccat gcttattcta gctggggaaaggcttttctt

66661 gttaaaacac acgtttgaga gaggcaagtg aatcaatcat tctaagtatcatgcacaagc

66721 tccctacttg agagatcaac cgcttagctg aagggagatt ctgttggggtcactcacatt

66781 ttgtagagct ttctgctgtt taggatgcat tttgacacac atgatctcatttaacctgca

66841 tacaacctta caggtagctg gtgtctctgc ttgtaactga aaaacacaaggctatgtggt

66901 catttgccct cacacctggc aacatgtcag gtctggggtt caatcccaagttcagcaacc

66961 cccagtacat gcctctgtct atcttaacat ggccaccctg acaggaactgacacctccaa

67021 atccaaatga gacctgatgg cttaaaatga gggttcggga aaagtagtagtgatgtcaaa

67081 aattactggt gctctggctc tctctctctc tgtctctctc tctgtccttatatcttttta

67141 gcttaaaaag ccaataattg gctggtcaca gtggctcgtg cctgcattcccagcactttg

67201 ggaggccaag gcaggcagat cacctgaggt caggagttca agaccagcctggccaacatg

67261 gtaaaaccca atctctacta aaaaaaaaat acaaaaatta gccgggcggggtggcatatg

67321 cttgtaatcc cagctacttg ggaggctggg gcagaagaat cgcttgaacccaggaggtgg

67381 aggctgcagt gagctgagat catgccactg cactccaggc ctgagtgacagagagagact

67441 cagtgtgaaa aaaaaaaaaa agccattaat catttgtggt aagctccacaaggaagaatt

67501 tgttgcaatc ccacctgtgc ctggctccag caggtttcca ggaaacatttgttgcatgaa

67561 tgaacaactg aaatagggct tcccaggata taagtaagat tgcagagctggacgccacat

67621 aaaggacaca gcagagtgca cacaacatac aatcagtagg ctgaaaaaggcggctcaggc

67681 aggcaccaaa gccgcactgg ccatacaaac aaagaaattc agcaaacaatgtggaaaggg

67741 gggggagcca aattccagaa atgcaaagac gtatcagagg cctgcaggcttacatgagaa

67801 ttcctggagc aggaaattaa atgcaagtta atgaagactt tgaaagctttattcctgagt

67861 gcatgaaacc tgtgacatgg gtttggcagc tctttctgaa gcagagccatcgacgctggg

67921 gaagaacgca gggcacttgg catcacctag gagctttaaa aatacagattccagcctggg

67981 cacggtggct catgcctgta attccagcac tttgggaggc cgaggcagacagatcacttg

68041 aggccgggag tttgagaaca gcctggccaa catggcaaaa ccccatctgtataaaaaaga

68101 caaaaattag cccggtgtgg tagtgcatgc ctgtaatccc agctactcaggaggctgagg

68161 cagaagaatc acttgaaccc aggaggcaga gggttgcagt gagccgagatcatgccactg

68221 cactccagcc tgggcaacag agtaagactc catcaaaaaa ataaaaatacagatgcctga

68281 gctgcatgtc caggattgga ttggattggt ctggaggtgg cctgggcatcagtgttttta

68341 atgcctctcc ctcccttcgg cccagcaagt taagtctagt gaacactgacttagaggtta

68401 gccaactcat actcctctat aaatgaagac acttgaggca tagaaggagaaagagccagg

68461 atcacccagc agatgagagg cagtggtcag aatggagccc aggaggccagtgctggctcc

68521 cgggccctcc ctctgaccct gctgccccag cccctggacc cctgcgggaccaggctccta

68581 ggctcaggca gctttccttc tggctccccc ttctcctgcc tgcaggtcagcatcacggtg

68641 atcgaggccc ggcagctggt gggcttgaac atggaccctg tggtgtgcgtggaggtgggt

68701 gacgacaaga agtacacatc catgaaggag tccactaact gcccctattacaacgaggtc

68761 agtggccctg tggggaaagg agcctctgta aatatggcag gagggtggccccagccctcc

68821 ccaggagaaa taggagtggc tggaagtcaa ggagcacaca gggctaccagcaggggtgat

68881 ccaccctgtt acaaccccca ggacactgac aaacagagcc acatcttctgaatcctctga

68941 accccccagt ctagagcaca ggccgacact ggtctttgaa gcgtacaccacccgggtgct

69001 cctgggcaga ccccagcagt gcctgtgaaa gaaccccccc ccaccccactccccaagagg

69061 cctggttccc actgtttccc aggccagagc ccaaggacag ggctgcctcattccaaccca

69121 tggtggcact ggcaccatta gtaagcactt tctaccagcc aggcatgctcctaaatgctt

69181 ctgaactgga ccatccaaag ttgtcactat caattccctt ttacacaaggggacagtgag

69241 acttctgaag gcagaccttg tccaacctca cagtgccagc atcgcccttggcgtgctagt

69301 ggggttctgc cctcttggct cggctccttc atggttgcct aaacttctgcgggcttctct

69361 ccagagcact ggccttgatt ttagggtgtg aaagagaaaa catttggtacccactcctat

69421 tctttccagc catttgaggc cacatcaagg gtgagggacc tcagagaccttctactttaa

69481 tctccccatc ttacagagga ggatactgag gcctccatat ggaagggccttgcccacaat

69541 ctcagagagt gttgctgata gagcaggggc caggctgccc acccagcttccagcccaggg

69601 ctctggccac catcacaaat atggcacctt ggttcccagg ctccagatgggaccccatca

69661 taatcagctc tggggaggga tgtgagaaat agagaaatac actcactcatcaaaacccaa

69721 agaatgactt agaggcatga agaacagcga aagtgagact tttaataacggtcttgcaag

69781 atggagtgtc tggtaggcag gcacccctgg ggcagtcaca acaggaatttatctcctagt

69841 gtgcaagtcc ctcccccact tccccattgg ttgagcacta tggggttacaatcttccctg

69901 acgtcgccta agtttcattt tcccccttac aaggttatac cccgctccccttcgatttcc

69961 ccacttaagt ttcgatttcc caataacaaa actttcttcc ctttcatgggctgacccctc

70021 ctctacattc tgttcgctta ttgtgtcctt ctaggtgcat gagccgtgtggtttgttgca

70081 ttcgcaggtt ggatgccagt acttagactt atcctgcctt gaaaatggaccattgaaaat

70141 gttttctcac caggatgccc aggcctttcc cagatgcctg atcacacatcagactaaccc

70201 agaagccaca ggcctgggcc ctgccatccc tttcctggag ggttccccagtctgtttctc

70261 ctggtggctc caggcagtga ggggtgccag gctgtcccaa gtaaggcagctgagtcccgt

70321 accctgaggt gggtgagggc tgaggtgccc cctgtagctt gggggagggcatttctcagg

70381 cagctctgag agtcctcaga ctgtgcacct gcaggaagaa aacccaggcccacctctgcc

70441 cttcagccca ggcctggccg aactctcctt tgtgaccaca aattgactctgctctcccag

70501 ctgctttccc acaggccccc cgagctggac aacctgctca ggacccctccagccccaagg

70561 acattcagga ttgacatctc tggccttacg ttaggacaca tcctgactggacaagtctcc

70621 gcctagataa gcatctatgt ccccaagaca ggcatggaga caggtccctgtggccccggt

70681 ggttacttga tagcagtgaa gccacttctg ctaacttaag ggatctccctccaccaggcc

70741 cacacacctt ggctttcatt caaattactt cctctttccc aagggcacagagctgctctc

70801 cctactctgt ggctccccca gaaaactcct actcacccgg cagggcccagctcaaatgtt

70861 cttgctactg agcagccttg cctgctctgt ctgggtcaga ggtcagcactcccctttctc

70921 tgcagtgtta atgtcctgga gttgaggttg gtcctccgtg tctctgtcctgctggtggac

70981 tggaggctcc cagtctcctg cctcgctatt tgttcagagc caggcatgtactcggagggg

71041 ttcagtaaca ctcacccaaa ggaagacaca aacatccact gagcatctgccgcacaccag

71101 acagtggcac gtggggcaac atggaggctg ccgagatgaa ggaggcacagtttccgccct

71161 gcgcaggtcc cctccttgtt tcagcctaga atctttctaa attccctatttacttcctct

71221 aagactgact attcattctg ctcatctttg gacaatctta aatgtgtttctgatcacatt

71281 tttgttcttt ttcacaaacc caaatagctc tgattttgtt tctgtttcctctaaactagg

71341 gtttctcaaa ctcagcacta tggtatcttg gactggataa ttgtggtgggatcgtcctgt

71401 gctgtgtagg atgtgagcag catccctggc ctctacccag tagatgccaatagcaactcc

71461 ccttagttac agctaccaag tttccagaca tgccaaatgt cccctgaaatcgccctcagt

71521 tgagaccacc attctaaact atcttactat gattccttcc agccccaaatcagcctttcc

71581 agccccaaag ctttgtttcc cttttcttct ctttctatgc cacattccttttcaatgaag

71641 gacatcctcc tcgtcgtggg aatgtattat ttctgactaa ttatctgagctggtaggaac

71701 cttcctttgg ctccattaaa acaacagagg gaggtgggaa caatcaacatgacttaggta

71761 tctaagctat tacaaaagga aaatatgctc aggaaataac aggaatttgattgcagacag

71821 ctcagagagt tcgggattct ggctctagct cagctagctc gctcccctggggctggcaca

71881 tctgcgggca cctggcctga tcaccctgcc tggccctgag cctgcctgtgtgcagggaag

71941 ctcaaaacct ttgcccttcc ggaacaagct ggccattcac aaaccagactaaggctcctt

72001 tcctgtgtgt cctgtgtgtg catctggccc cgccctgggc atcttgggagcgccaccatc

72061 cttcctcctg ctgaaaatcc acctctcccc tttgccttgg atccttctctttctacagct

72121 caaagaacct ggcattgcac agcccaactc tgtctttgtt tttcttccagccccttcttc

72181 cttgcctata aggtgttcta ctccagcata tgctaagtac aaccatgaagacccatgtgt

72241 gctcaaggac aggaactagg agtctgtcac ctctctctgg gcctttcctcattcccacac

72301 acttctccag tgacctcctt tttccctcca cccctccaca gtcagaccacttgggttgtc

72361 ctcacttcct ccccccagtc acccctcaat ctctgcaggg tttctgcctccagatgtcat

72421 tgacactgct ctcctcaagg tcaccaagga cattgctgtt cctgagtataatgtccatgt

72481 catcctcctc tcccttgatc acccagtttc tttcatcccg ctgcctgctgctcctcttgg

72541 gggcccctca cgccactctc ctgcttcccc tgtctctcca gctccatctccccggcctaa

72601 cttcttggct gaaaggctgt gtcttcttgg agccctgacc tgggcctgcttcccctccca

72661 tgctctcccc aggtatctcc tccatctcca aggtgtcagt taccatcttgtgctgacgat

72721 tcccaaatcc atatccccac ccgcctcccc agagcttcag aactctggccagcacaccct

72781 gggcctgtta gtgtcatgca cagctgtcgc tgcttgctat gtgcttaccgtggtgcacac

72841 ctgtgttaaa gacttgacca gggtgtctca ttgcaacttc acaaccacaccttgaagccc

72901 cccaagtgaa tggcacccct ggagcagttc agcacgacag ccctggatcatatctccaca

72961 ttcataggat aataggtaaa ctgaggctca ggcaagaaag tgagtgatctagcagtaaca

73021 gccaggtggg gctggctctg aagctggctt taccctcagt gctcaagggccagcccccag

73081 cagccaggag cacgttctct tcggacattt accccaagca cattggaaatatttctccct

73141 tctcccccac cacagttcac caaagcagca gcccctctac tcactgccccacaccctcat

73201 cctcagcacc tgcacaccca ggccagggga agagatgggg actgcaaatgtgcatggcag

73261 cccacagcac caaaggacag tgcacaccca tggcatttca catcgactgccaactaagtg

73321 cttggcacac catggttcat ctgctctgag gcttgcgtta ttttacagtttcacctctct

73381 gaatttggga tgtgtctcct aggcagcctt gtggcttcat ggcaatgtccatgtggctta

73441 ttaaaccgta gtatatctta cagccagtag ccactttaga tttggtaaaatatgttacac

73501 tgtctcatca gagcctcata acaagactct gaggtgggtg tcattatccccatttcacag

73561 ctcaaaaaac tgaggttcag agaatgtgtt gctcaaggcc acacagttaagaaggtgcag

73621 agcggggact agaacccagg tctgcttgct ccctggccct gtgcctcttctgagcacagt

73681 acaagggcat gggctgtccc acctactgtt ccaagttcct ttcccaccccacactagcca

73741 gcaccagccc cacctagggg atggggctct gcttcctacc acccaccaccagggtcaatc

73801 aggatcagat gagttgcctc tgctgctcct ctgaactttg gggctcagggcaaatgtctg

73861 gggtgcagac aggccctgcg aggagggagg ggcccaacac tgcctgggctgttgctgctg

73921 ccctcagtga cagcaggcct ggatccttcc ccctccagta cttcgtcttcgacttccatg

73981 tctctccgga tgtcatgttt gacaagatca tcaagatttc ggtgagtggggagcagcccc

74041 tggccggcag ggccactccc tcaaactgca cctttgtgca gacttgagaggggccccctc

74101 tgtctagacc catgataaag aggcagcgcc gtgcctggac acacggctgggcaagtaggg

74161 acaggctgga ttctggcccc cacccacccc tttcattgga tgcctctgaatagtgcattc

74221 gcccgtaaac agtggccagc aagaaactgg cgtgggcagg aggagctgatgctgagcctc

74281 agtgagccac cccactctgc caacgccctc ccacttcacc acaaagctcgggtcccacca

74341 ctgccccatg gaaagcctca cccttgctgg gcctgacggg tgggctgtggttctgcctga

74401 aaggtgattc actccaagaa cctgctgcgc agtggcaccc tggtgggctccttcaaaatg

74461 gacgtgggaa ccgtgtactc gcagccaggt gagtacctgc gcatggccagtcagtcgagg

74521 tgtgcatggc tcagggagcg tggtgcacgg ggcccttccc actgtggcagttcctgggaa

74581 aaggctggca aggaccacag tctggcgact gttagtacac acagccatctggcctgcgga

74641 gaagtggcgc gcacagtctg tacacaaatg cagtgagcaa ctgcgcacccagtctggtgg

74701 gttctcactc ataattaggt gagtaactct gcacagagcc tggaaggagcttcatcacac

74761 gctctggagt gcatggcagg ctggtgcatc actggccata ggcaggctgaccagtagtgg

74821 tagaggatgc ggtgagggag acccgtcaca gcctgcagag aggctgcgcccagactcctg

74881 cctcctgggc tggcacctgc tgagcagaaa agaacccctt tccacccctcacaggaccct

74941 gccgtcccct tttacagttg aggctcagag ccagggcttg ccccagccacacagctggcc

75001 gggggtgaag tcaggctgtg tgtccccaga gcctcactga gccacactatccaatctgaa

75061 agcggtgatg ctggtcaatg ccagatgtag tgcggcggcc tctgagggactctggtctct

75121 gaaaacactt cttacaagag ccccaggctt ttgggcagcc atgtgtgctccgtggcgtcc

75181 tgtagggtaa cagcaatggt gttggcaagg gaaccccaag gggtggcccagagggcttgt

75241 gaggtgggcc aggcagagga agtgcctcag cctgccagat gacagctcaccacgtgggca

75301 ggttagggac caccctgtgt ccctgaagtg aatgcactgc tcagagtgctgtaatgaccc

75361 cattaggcgc tttgacagtg agaacataat ttcacccaat tgtcacattgggccctcaca

75421 aaacagtaat gtaggcagca gcatttcttc ccattttgca catgagataaatgaggctaa

75481 gagaaatgaa ggggcttaga gataccacta aactagtagg ttgaacaaattggcgatcgc

75541 ttgtggttca acctaagaga cgtccagctg gtgcacatta caactatgacttagaccagg

75601 gaatctgagt ccaaaaccaa gattatacac ataaaaatca caagatcatagaacactcaa

75661 gctgcccaag acctgaaaaa catctagtcc agcctctgtg aagataaactgaagcccaag

75721 gtgatgaagg ggtttgtcca ccatctagga gtagcacccc tgtctccagctcccaggcca

75781 gtgcctttgc caccacccca cacatgccat agccctcagc ggagggcagccctgctgacc

75841 atcagtgcca tggggagcag ggaagagtcg gcctcctgcc atgttgctttccaggaagca

75901 tgcatagccg tggactactt gcttggaatg actggcatcc ctgaggataagctcctccca

75961 gggctgagca gtggccctgg taccactggc aggcctgagg ccgagagccaagagaaagtc

76021 agggggtgga gaaaaaggca gatattagtc taatatggac ctctgggcttctgggtagta

76081 aagtcctggt gaggaaacca ccagggcatc agtaagtgcc agatgttgggctaagctcac

76141 tgtcccagca ggcctcaccc tcacgacccc atataggcat cattcccatttcaccataag

76201 gaaactgagg ctcagcaggc ttaaacagct ggtccagggc cacattgtgagtaagcggca

76261 gaaacaggat gtgggccgag gtctccactt gggtaaccta gctcgagatttgctgcttct

76321 gctgaatcca gccctgagcc tggtgccctc ccagggacag gagagcctgaagtcacatgg

76381 gtcctggagt tgagacccaa tgtctttact ctgatatctc cagtttggcctgaacttctt

76441 gatgagtcgt tggttccagc cagggcattg ttggacagca tgctcccagagacactcctg

76501 ggtgctgctg ggaagctttg ggtggtgtcg atatctcttg gaactggaaggggtttcccg

76561 agagaacctc ttctcaccct ggcaggacca cattttgtca tttgtaccaccagatgcaac

76621 atcaggaaac tgtttactgt ttgctactct ctgttggggg tgaggacgggccatacactc

76681 atcctcatag atcatagagg aagtcagggg catacactca tcctcatagatcataaagga

76741 ggtctgggat gcagcaactt ccccagctgg gctacccttg actggcaggtgtcagcccca

76801 ggctgaaggg aggtgaaatg atgtttcagg ctggtaagca tatagctcaggatctcatgt

76861 ggtccttgta tctctagcct gagatcacac agtattagga ctagaagggcctcagaagtc

76921 atgagtcaag tgttaacctg atgtagggac ccccacagca ccatctctgattggtcctct

76981 aaccttgctt agtcctccca gaaatggggc actcactact tcttattttagatatcttca

77041 ctttctttag gtcatctcaa aatctgtcac cctgtaacct tcacccactttcacacgtct

77101 ctctttcagg acaaaaagaa aaatagcctt taaatttgaa ggtaaattttacattcctcc

77161 tgaaccgtat tctctttctt tgctaaatgt ccccaattca tctaaccatgcacacctcta

77221 tacatctacc cctgtatcca tccatccact cacccaccca tctacaaatccatccaccca

77281 cctgtccaca gatccaccca cccatccatg tatccatcca ttcacgcaccaatccatata

77341 tccattggtc cacccaccca cccatccgtg aatccatcca cccacccacccgcctgtcta

77401 cagatccacc cactcaccca tatatccatc catccaccca cccacccatccatatatcta

77461 cccacccatc tatccacaga tccatccacc tacccaccca tccacagatccacccaccca

77521 tatatccacc catccaccca cccatccata tatctaccca cccacctgtccacagattaa

77581 tggctccttc tatccagtaa tccattcacc atctgtccgt ctatctctcagccggccagg

77641 cagctcacca cccatccctc tgcccattta tgcacccatt cattgagctttctgtccatc

77701 tcctcatccg acacacatct gctctggcaa gacctgaagc tcctgggattcctgggacat

77761 ggcccctccc tggaggcctg ccagcctggc tgaggttctc cagtgactcctcatccacgt

77821 gccttcctgc cctctcacct tgcttgtccc tctcttcaga ctctactgtggcattatctt

77881 ttctgagaca caggtggcct ggctattccc agaaaggcca acctctgtacacagccccta

77941 acatctccgg gagcccacca gggccacagg cttgcaggac acaggcctgggctacggtag

78001 aaggtggaag aggagggagt gaaggaggga ggtgctgagt ccctgagagttcagtgccca

78061 cctaacatcc cgggaagcag attcctaagg cacagtgatg cgcttccctttgcttgccca

78121 ctgggcttaa agtaaacctg aaggggcaaa tccttcctaa agcgcctccttccctgacat

78181 ccgtcctttc ctccacacag tcataggtca tgggacactg ggatgagactgacaatccct

78241 gtctttagga gactctcagt ctaaaatcag agccaaacaa tacccagatcagcacagtga

78301 gatgggaggt gtgcatggag agcacagaga acaaacacta aagagcccaggatcaactct

78361 tccgaggaag tcagggaggg ctgcatggag gaggagagac ttgagcaaaatgagtagaag

78421 tttacaaatt gaatagggag aaagacaggt ggaggtggag agaacaggaatgagggcatt

78481 ccaagctcaa agagcagcag atgcaaaggc atggaggtat aaaagggcatataaaaccgc

78541 aacacctgtt cagcaaggag gaacacaggg ctgggtgggc tcagcagagtgagtcaggga

78601 gcactaaatc aggagcctgc aggccatgcc ttttgtcttc accccaaggcactgggaagc

78661 cccagagggg ctgaagatgg ggagcaggag catgagcctc cacctgggaaggccctgtgt

78721 gcagctgtgt ccttcacagc tatgtgaagg ctggctgact ggggtggggccatagaagag

78781 gccacaggca gaaaaaccca attaggagga ggctgtcgtg cttccaagtcacaccactca

78841 tgggatatat gtccatgggc aggccatgca cccactgccc cagctccagaggacctcaga

78901 ctctatcaca ccctgggcta gggacaggca gagctgtggc cccaggtcccgggactctag

78961 ggaccaagac agcatttggt tctgccaccc cttggcctgc cctgagcactgggagacgct

79021 ctgggtgggg gtgtctggtg cagtgcccac ccctcatcat tgcagagcaccagttccatc

79081 acaagtgggc catcctgtct gaccccgatg acatctcctc ggggctgaagggctacgtga

79141 agtgtgacgt tgccgtggtg ggcaaagggg acaacatcaa gacgccccacaaggccaatg

79201 agaccgacga agatgacatt gaggggtgag gcccagctac cccagcccctggagtctgag

79261 ccagcccttc cttcccccag ggagcccccg gtgagggttt gctgagagcacctgccaccc

79321 gtctccctca ccctgctctc gctcactctc ccaagcagcc ccactcttccgaggcagggc

79381 aggggcaggg ggtgatggag gatggctgag aatatcagtc ctttgacatcctttctgcca

79441 gtgagaaatg ggttgagaag agtcgatgct ggcagaccag aaccagcagctgctgggtcc

79501 tgagtatagc agcaggaagt gctgggagag ccaaggtttc ttctggtgtgccaattccag

79561 gcagctgata gcagctgttg agaaatattc tgtgaccttg tctggagtcagtgggtaaaa

79621 gtgctgggaa tcaatgaatc ctgtcttttg tgagctgggg gagagagagtggctactgtg

79681 aagtttttgt ctacgaaaca aaagatacgg cacaaaacta taaaacactgacaataatac

79741 taagatcata tcccaatgta caatctacaa agcactcata tgttttagcgtgcttgagcc

79801 gatcatgttc ttgggaggtg ggtattatta cagccacctc aacagtgaggaaacggcagc

79861 tcagtgagat gggaagattt gcccagaatc ccacaagggg caagttccgtgaacacaagt

79921 gtctaatcct agccttgctc cctcagctgt cccttagaga ctgtgccaggacccaggagt

79981 gtgtagatgc caggatgggg gttggggacc tggacctggt gaccatggccctggctgtat

80041 gtgctggcag gaacttgctg ctccccgagg gggtgccccc cgaacgccagtgggcccggt

80101 tctatgtgaa aatttaccga gcagaggggc tgccccgtat gaacacaagcctcatggcca

80161 atgtaaagaa ggctttcatc ggtgaaaaca aggacctcgt ggacccctacgtgcaagtct

80221 tctttgctgg ccagaaggta ctggggtatg aggtacagga ggctggggctgggtgacagg

80281 tatcacaagg gcaggctgat gggtgtgggg cctggggcag ctgggcaggtaagacaaggc

80341 tggaaatcat gttggccagg gacggactta gaggatcctc actgcctcctggagtcctta

80401 gactgagagc tgcgcagggg gcatgagagg gaggagaggc tgggggtgtgggaagagtgg

80461 agacaagtcc acacacaggc acgcacacac acatgcaccc actcatacacgcacgcatac

80521 caactcacac acgcacgcat accaactcac acatgcagac acgcacccactcacccgtgc

80581 acacgtgcac ccacgaatac acacacacat gcacccattc acacacgcacacacacccac

80641 tcacacatgc acacatgcac ccactcacac acgcacacac acccattcacacatgcacac

80701 atgcacccac tcacacacgc acgcataccc actcacacgt gcacacatgcacccacgaat

80761 acatacatgc acccactcac acgcacacat gcacccatta acacacgcacacatgcaacc

80821 actcacacac gcacacatgc atccactcac gcacacatgc acccactcacgcacacatgc

80881 acccactcat acacacacat gcatccactc acacacgcac gcgcacccactcacacatgc

80941 acccactcac acacgcacac atgcatccac tcacacacgc atgcacacccactcacacat

81001 gcacacatgt gcccactcac gcacacatgc gcccactcac acacacacacatgcacccac

81061 tcacacacac atgccacgcc ctcacctgtg ctcccccttc caccagggcaagacttcagt

81121 gcagaagagc agctatgagc ccctgtggaa tgagcaggtc gtctttacagacctcttccc

81181 cccactctgc aaacgcatga aggtgcagat ccgagactcg gacaaggtcaacgacgtggc

81241 catcggcacc cacttcattg acctgcgcaa gatttctaat gacggagacaaaggtcagca

81301 gcgggagacc cggtgtgctg gggggcagag ggagtggcct gaagggaaggaatatgtgag

81361 atgccctctc ttcacaccac cgtcatcagc tctggtcctc agcctcacaggtgcttccag

81421 ggccttgcca gcagcccctg cctcaggggg agggtgagga tttgtggctcaggtcggctc

81481 agagctggcc tgagcccagc tgactggatt tgtcagctag tagttgtgtgacctgttttc

81541 ccatttgtaa agtgaaaata ataatgatta tatgatatga taattatagtatgatatgca

81601 cattatagca gtgtatatac tgcatttgta tataattaca gtgtgtgtgtatatatatat

81661 gatacctaat agtagtgcct atctgcagaa tcgcagggat tgactacctcctaggatccc

81721 tgccctgtgc tgggttccaa ggacatagag tgagataaga atctattcctggatcaaagt

81781 gctcactgtg tattgaggag atagatgtgc taccaaatgg tcaaaacataaggcagaaga

81841 cacaaaaggc cacatgttgt ctgatccatg tatgtgaaac atccggcaaatccacagaga

81901 cagaaagtag attgccggtt tccaggtgct aaagggaggg gattgggactaactgctaaa

81961 taggtgcaga gtttcttttg agggggtgga actgctctgg aagtagatgatggtttatag

82021 cacagtgaat atacgaaaaa ccactgaaat gtacacttta aaagggtgaattttatgtca

82081 tgtgaagtat atctaaattt ttaaaatgct ataagtgtgt tttttaaaaaaaggcagaat

82141 aaaaaggaaa tgaaccaaaa aaactggatc atgagacccc tgtcagaggcctgacaaatc

82201 ttagccataa gagaagggac ttgtgcctag gaattgggaa ggcttcgtgaggaagcagca

82261 tttcacaggc agagatggag agggatggcc ttcagcaagg aggggaggggtctgcactgg

82321 cagggtcacc gtggtgggac agagctgcaa aaatggcaca gggcccaaggtcatgctgcg

82381 gacttggaag gactggctct gtcctacaag tagactgttg acaattcctgctctaagttc

82441 caggaagcag ggagctagac tttgccttcc cactgcttcc agctcaggcccccgcaggga

82501 agaaatagac ccaagagagt gctccacccc agcgcagtgt aagaaggctgccccacacct

82561 gaatggcaca catgaagttc tcagctcagc acccaggagc tggaggccagggacccccaa

82621 aagaggcccc tcttccccag ggaaactgga tgtgacgctg ccccctcatttttgttccca

82681 ctgccacagg cttcctgccc acactgggcc cagcctgggt gaacatgtacggctccacac

82741 gtaactacac gctgctggat gagcatcagg acctgaacga gggcctgggggagggtgtgt

82801 ccttccgggc ccggctcctg ctgggcctgg ctgtggagat cgtagacacctccaaccctg

82861 agctcaccag ctccacagag gtgcaggtgg agcaggccac gcccatctcggaggtgagac

82921 cccaggcact gtgctgtccc ccagggcctc cagctcagcc cccttctccctgagtcacct

82981 gggtcccagg ctttgcctgt tgctgccctg tctacctgag gagtcatacctcaggataag

83041 gcttctcccc aggaagcaga ggcccccact cagccccgca acaggactctgccctcgtcc

83101 actgcctgcc tgtgctctgt ctcacaacgg ccgccaggtc tcacgatggtgcctcccctc

83161 tgcccctctt cccagccacg gctgtccctg tggtgtctgc agccagccctgcttccatgg

83221 atatccaggc tggggggccg ttggggtgtg ggctgcctgg ccccaaagccgggtgggatg

83281 cccccaccat ccacccccac ggcctgtctg tgagacggaa ggaggcctggcccccgacct

83341 gccaccctta ctcaagctca ggaacgcttt gaactgcctc cccacagagctgtgcaggta

83401 aaatggaaga attctttctc tttggagcct tcctggaggc ctcaatgatcgaccggagaa

83461 acggagacaa gcccatcacc tttgaggtca ccataggtga gtgctgggcccacgggggct

83521 tcgggcctag gtgagtgctg ggcccacggg ggcttcaggc ctaggctgcaggtggtaagt

83581 gtgaggctct gcacctcagc cctgtcctca ctcttgtagg gaacgttgacccctttcccc

83641 tgagaggcct caagcaccca caaaacacct ttgtgtgtgc atggggtggaccacgcccca

83701 taaaggggcc aaccctcagc tccacctaca gggtgaggct gtgtttgggacctggggcag

83761 agggcaggga gaagcccttc ccggggctgg agaggagaga gtgggaactcaggccacagc

83821 ctgggccagg gctgggcctc gcactcaggc gtcatgagga ctccctgactctcagcggag

83881 tggggacacg ggctaatgct ctctggctaa tgatgtgtca cgtctgagccccattccctg

83941 actctccctc tcccctttcc caaacccaag gcagcaccgg attggacggtgggaggggcc

84001 tggtggggaa tgcactctag gccttctggg cccattctgc tccaggcaactatgggaacg

84061 aagttgatgg cctgtcccgg ccccagcggc ctcggccccg gaaggagccgggggatgagg

84121 aagaagtaga cctgattcag aacgcaagtg atgacgaggc cggtgatgccggggacctgg

84181 cctcagtctc ctccactcca ccaatgcggc cccaggtcac cgacaggtgggcccagcctc

84241 ccatcctcct gtggcctggc cctcccacct ccctgggccc ccaagacctcacctcccgcc

84301 tctgcccacc ccaggaacta cttccatctg ccctacctgg agcgaaagccctgcatctac

84361 atcaagagct ggtggccgga ccagcgccgc cgcctctaca atgccaacatcatggaccac

84421 attgccgaca agctggtcag ggccaggcca ggggccagca ggggtggggtcctgggggag

84481 acggcgctgt cagagggcct tccctggaac acacaaagct ggtctgcccagggggctgca

84541 ggaacggccc cagcaggacc tctgttccca ttctcagccc caggtcccagggcacagaca

84601 aggacaggag ccacctctag tcactcagcc tccagtgaat cctggggcaggagtgttggg

84661 ttccctgatt tttccagaaa tcttaaaagc aaggctaggg agacaggtgtggtggctcac

84721 gcctgtaatc ccaacacttt gggaggccaa ggcaggtgga tcacctgaggtcaggagttc

84781 gagaccatcc tggccaacat agtgaaatgc cgtctctact aaaaatgcaaaaattagcgg

84841 ggcttggtgg cgggcacctg taatcccagc tattcgggag gctgaagcaggagaatcgct

84901 tgaacccgtg aggcggagtt tgcagtgagc caagatggcg ccactgcactccagcctggg

84961 caaccgagca aaacttcatc tcaaaaaata aaataaaata aaataaaacaaaataaaaaa

85021 gcaaggctag ggaagggaaa tggggaaaag ggagaagcga gcagtgtctgaagctcagga

85081 gctgccccct cctcctctgc ccacccctct ccccccatga gccatgggcactgactgggc

85141 gaggagtgca gctgttggca tgagacctcc ttctccccag cctggggaagcagggaccag

85201 cagataatcc cgcccttccc tgagctgttg ctgttccctg ttgaagttccctgaagctca

85261 gccagctcat attttataaa aatgaattaa aacctccaaa aaaatcaaggctaatatgag

85321 gtctgctccc agccccctgc caatgtcctc cttgtcatcc ctgtcttgtgactataacca

85381 caattaaagc ccatagcctt tgcagtgtga cctgggtctg cagttatctgcaaggcttcc

85441 ccctaaggag ctggggtaca agctgacctg tgtttcctgt gggacctgggtctcacagcc

85501 ctcccagtgc tctcagagcc agagccactc cctcttcccc caggcatctgttcccatccc

85561 ctgccacagg ctccagcatt ctggagtgac gtcaggatct tggcacatccagtcctaggg

85621 tttccctctg tctctggcca gccctgagcc ccgtagccgt gagttctgcccaggccctgt

85681 gagctcacca gagccacaga ctcacagccc agaggtggct tcttccttcaggaactgaag

85741 aacccccatg aacaccaaca tctccaggtt ctgagaacag aacctgggaaattgatgact

85801 tcctcatgat gaccgatact caggatggcc ctagcgagag ctcccagatcatgaggtccc

85861 tcactcccct gatcaacagg gaggaggcat ttggggaggc tggggaggcggggctgtggc

85921 ccagcatcac ccacactcct gattcacagg aagaaggcct gaacgacatacaggagatga

85981 tcaaaacgga gaagtcctac cctgagcgtc gcctgcgggg cgtcctggaggagctgagct

86041 gtggctgctg gtgagaaggg aggggcggca ggtgggggga ggatgaggcggaactggaca

86101 aaggggaccc tgccagggct gggcagatga ggaagaatct acagagcccctgctggtcag

86161 gctcgctaaa ccccggctcg ccctaccccc agccgcttcc tctccctcgctgacaaggac

86221 cagggccact catcccgcac caggcttgac cgggagcgcc tcaagtcctgcatgagggag

86281 ctggtgagga cgcaactgga cggcgggggc tggagggagg gcctggttgtgagaaggtgt

86341 cacaaccccc tttgtcatgg cccgagctgt cccccagttg ctgggttcactgacaccccc

86401 tccttcgcag gaaaacatgg ggcagcaggc caggatgctg cgggcccaggtgaagcggca

86461 cacggtgcgg gacaagctga ggctgtgcca gaacttcctg cagaagctgcgcttcctggc

86521 ggacgaggtg cggcccaagg ggtcggggct ttgcctcatc cagggctggctctctggggc

86581 ccctcaggat cagggggctc aatcaggagg ctagaccccc ttacccactgcccctggcca

86641 ccccccaacc cccagcccca gcacagcatt cccgacatct tcatctggatgatgagcaac

86701 aacaagcgtg tcgcctatgc ccgtgtgccc tccaaggacc tgctcttctccatcgtggag

86761 gaggagactg gcaaggactg cgccaaggtc aagacgctct tccttaaggtgctggagggg

86821 gcaggatgga tgggggcctg ggtcctttca ggggagcagc agcccccacctggggctgga

86881 agcctgagtg acagggtggg gccttcaagc agcaggtgct cagagaagagccaagaatgg

86941 gaaggacgtg ggggaagggg tggggaagga ggtgggggaa ggggtgggggaaggggtggg

87001 gaaggaggtg ggggaagggg tgggggaagg ggtgggggaa ggggtggggaaggaggtggg

87061 ggaaggggtg ggggaagggg tggggaagga ggtgggggaa ggggtgagggaaggggtggg

87121 ggaaggggtg gggaaggagg tgggggaagg ggtggggaag gaggtgggggaaggggtggg

87181 gaaggaggtg ggggaagggg tggggaaggg ggcatgacgg ccccctgcccatcctcctgc

87241 ctccaccgga ccccagccca gcgggatggc tgtgaagggg cagggcagctctgaccaggg

87301 cctctgccgg cccctgcccc ttccccacct cttgggccct ggcagccgtcaggctcctgg

87361 tgaccccatg cccaccccca gctgccaggg aagcggggct tcggctcggcaggctggaca

87421 gtgcaggcca aggtggagct gtacctgtgg ctgggcctca gcaaacagcgcaaggagttc

87481 ctgtgcggcc tgccctgtgg cttccaggag gtcaaggcag cccagggcctgggcctgcat

87541 gccttcccac ccgtcagcct ggtctacacc agtgagtgag gacccctcactcgaagcctc

87601 acctgggagg gggccggagg ggctgcccat cctggaacctcaggctgcccttccccacag

87661 agaagcaggc gttccagctc cgagcgcaca tgtaccaggc ccgcagcctctttgccgccg

87721 acagcagcgg actctcagac ccctttgccc gcgtcttctt catcaatcagagtcagtgca

87781 cagaggtgag ggcctgggag gagggagtgg ctctggcttt gagagcaccagaagcctgtg

87841 agcctgtggg gactggagcc tgtggggcct gtgagcctgt ggggcctggagccacaggtc

87901 agccagtgcc ccggtttctc aggggaagcc ctgcagataa ctgcagcagacgcgggtcac

87961 actggaaagg ctacgggctt tagctgtggt tatattcaca agacagggacgacaaggagg

88021 acattggcag ggggcttggg ccaaacctca tattagcctt gattttaagatttctggaag

88081 aatcaagaca cctgtcactc ctgcccccag gttccgtgga agctgagtgagtaggggtgg

88141 cttctgtttg tgcatctgcc cccccctctg tcacttgtcc cctgtctccccatcccatgc

88201 tgcaggtgct gaatgagacc ctgtgtccca cctgggacca gatgctggtgttcgacaacc

88261 tggagctcta tggtgaagct catgagctga gggacgatcc gcccatcattgtcattgaaa

88321 tctatgacca ggattccatg gtatgggtgg gctctggtgc cagggaccccagcagcacca

88381 cacctggccc ttgttccctg cactccacct gcgctgaggc tgtgccctcacctccgccac

88441 ccacctgcag agctccttgg ccaggtgctg gctgggaagc tgggagtgggggctgacatc

88501 tagctcctcc tgcctgcttg cggcagcctg accccttccc aggccagcacatcctcacct

88561 cctgtctcct acagactgag ccctggaggt gtgccagcaa gtcctgctgtcactagcctc

88621 cccaccccag ggctccccga cccctgccct cacctaccac aaccagtaacagccttgcca

88681 tcctccgtgg aggttctgga gcagggagta agggattggg gtgacccccgagagttagcg

88741 agccaccttc tcacatacca cctcagctgc tgaggtgccc agatagccctggactagagg

88801 taggaggacc tcatgtctag tcctgagccg ggcatctgcc atttactgactgcttggcct

88861 tgaacaagtc tttggtgggc cctgagactt ggtttcctca tctgtaaaatggggtgatca

88921 cacctgtccc ttacaacaac tcatggcgct gtggtaagga ccaaacgagatcacaggtgt

88981 ggacagcaag caccaagagg cttctgggtt gtctgttgcg tcagggcaaagctgacttca

89041 tgggccggac cttcgccaaa cccctggtga agatggcaga cgaggcgtactgcccacccc

89101 gcttcccacc tcagctcgag tactaccaga tctaccgtgg caacgccacagctggagacc

89161 tgctggcggc cttcgagctg ctgcaggtgg gactgcaggg aagaggggctgaggcctggg

89221 gactggaggc tgggagttgg ggcctagggc tgggggctgg accctgaaggctggggcctg

89281 gggtctgggg cctgggggtg gggcctgggg gctggaggct ggggcctggggctgggggct

89341 ggggctgagg gctggggcct ggggcctggg gggttagggc ctgggcgttaggtcctgggg

89401 gttggggcct ggagctgggg cctgggggct ggggcctagg ggcctctctcctacccatcc

89461 tgaccaaagc tgggggcgtg gtccttaggg ggtttccctg tctccccagatcatggcaaa

89521 caactcatgg ggaaagagac cctgtccctg ggctccccag tgtgtgacctgtgaccccca

89581 ttccccagat tggaccagca gggaaggctg acctgccccc catcaatggcccggtggacg

89641 tggaccgagg tcccatcatg cccgtgccca tgggcatccg gcccgtgctcagcaagtacc

89701 gagtggaggt gcgagggctc tgtgtggccc ttcccttttg gatgaggagtctgaggaccc

89761 aggaggggaa gtggcttgtc atccccctcc caccaccatc accaggagccagcagcagac

89821 ccaggctcct gccccagccc agggcctgcc cccatctgca ccaagtcgcactcccatgtc

89881 ccaggaccat gcccagccct cctgtctgca cccctgaccc tgcaccccttctccgggcag

89941 ccccaccctc atccctggag aacgcctgcc cctcctctgc tctcctggccctgctcccac

90001 cctttgaaat ctggggtgaa ctactgccca tcccactgcc cggttccctattggatggtc

90061 cagcaccccc atggctggct cccttgacta aggggctctc ttctctgcacccaccctcca

90121 acctctccca ggtgctgttc tggggcctac gggacctaaa gcgggtgaacctggcccagg

90181 tggaccggcc acgggtggac atcgagtgtg cagggaaggg ggtgcagtcgtccctgatcc

90241 acaattataa gaagaacccc aacttcaaca ccctcgtcaa gtggtttgaagtggtgagtg

90301 caggccctgg cggaggacat cctgtggcca gtgtggctcc actcagccagccggcttcct

90361 ctgccccttc ttggaggctc aggctcctgt cgccaacacc ccaggacctcccagagaacg

90421 agctgctgca cccgcccttg aacatccgtg tggtggactg ccgggccttcggtcgctaca

90481 cactggtggg ctcccatgcc gtcagctccc tgcgacgctt catctaccggcccccagacc

90541 gctcggcccc cagctggaac accacgggta tggccacatc caccctgccaccaagcctgg

90601 ctccacgccc cccagggaag ggctccaggt ctccgcccag tccaagccgcgaccagagtt

90661 tgctctttgg ggccgagggg gtgggcatag aagaaggtca ccctggtggccaaggaaggc

90721 tgcccaaggt gacgccagct ctacagccag agagggcaga actggagacagcctgggggg

90781 gcctgagggc agaaagcccc ttgcgctggt tgatggagaa gacccaggcctccccgccac

90841 ctccctccca ccggcctccg cagcttcccc ttatctcggg ctctcttcttccctccccat

90901 gcccatattt tctcccttga ctgcctgtcc ccctctccct cagaaagttccagaatcagc

90961 tttagttctc cgcaccttcc tgccccgcca atctcactgt tcctcttgctccttcctctg

91021 cctgtctgtc catctatcca tctgtccagt caggcttctc cggcgctgccgtgtgctgtg

91081 caatgggggc tcctcctctc actccacagg ggaggttgtg gtgactatggagccagaggt

91141 acccatcaag aaactggaga ccatggtgaa gctggacgcg gtaaggcgggtggggtcagc

91201 cccctgctgg ctgggaacat gcaacttcgt gtgacacatc ctgtgaaccagactatctgc

91261 cccgagagaa aaggacacta agagcctcct ttggcatgtg actgtcgggggctgagcttg

91321 attgtgtgtc caaacagctc cctcctaata ctatcctgga atgcacacgcgtgcgtgtgg

91381 tatgtaaatg tgcatgtgtg tgcgcatgtg tgtggtgtgc atatgtgcatgtgtgtgtgc

91441 atgcatgtga tgtatgtgca tttgtgcgtg catgcgtatg tgtggtgtgcatatgtgcat

91501 cgtgcatgta tgcatgtggt gtatgtgcat gtgtgtgtgc atgtatgtggggtatgtgca

91561 tatgcacgtg cgtgcgtgtg gtgtgcacat gtgcatgcat gtgtggtgtatgttcatatg

91621 cacgtgcatg catgcatgtg gtatgagcat gtgcatgtat gtgtgcatgcgtatggtgtg

91681 catatgtgca tgtggtgtgt gcatatgtgt gtgcatgtgg tgtgtaaatgcatatgtgca

91741 tgtgtgcagt gtgcatgcat gcgggtggta ggtaaatgtg catgagtgtggtatatatgc

91801 atatatgtgt gcatgtgcgc ttgtgtgcat atgtgcatgt gtgcatgtggtatgtaaatg

91861 tgcatgtgtg catgtgtgca tgtggtgtat gtgcatatat gtgtgcatgcatgcttgcgg

91921 tgtgcgtatg tgcacatgcg tgcatacatg tgggtgtgtg catgtgcactggcatgtggt

91981 atgtgtgtat gagagacaga gtgagccatc acagtttatt ataatcacctgctataattt

92041 ttactccaac aaatgacacc ataggtaatg attccttatg agatcatcagtgtcctttcc

92101 aaagagtccc tggttttcca tcccagccat tcacaaatga cacttccctggcctgggtca

92161 gaggaggatt tccaggtgga agctccttat tcctcctggc tttgggcctaggactgttca

92221 tctgccagag agagaactgc catctggggg ttgggtgtgg aagtggcgtacaagctgtag

92281 accctacagg gaagggcaga acgtgggcca gcctggaaca cagcccactgttcctttggc

92341 cacccaaaga aacatcctca ctcagaccct ttgcagactc accagtcagagtgctcttat

92401 taatgcaaag ttggccttgc gggcacaggg gctgccagca cacagtaatttccatctcgg

92461 ctcctccaca caccctgtgc taggccactg cctgccactc caggccccagtggctgattc

92521 tgcccctgtc tccttggttc ctctgcagac ttctgaagct gttgtcaaggtggatgtggt

92581 gagtgtgggg gccatgcagg ggctctgggg tgagagggtc ctttattggcaatgatgtca

92641 ggccaaaggg tccagcatca gggacagagc cagccccagc ccccgcatgcttgggccagc

92701 acacctcccc taagatgcag tggaaaagag ctgggtgagt gcaggactcggtgccagtcc

92761 tgcttgggcg agtggatcgc actggcaggt cacaacactc tgtggcctgtggcaccttct

92821 ccataaaata aggccctgcc ccttggacat gggtggcccc acagagcctcatggagccca

92881 aggcttcctg ctgacagatg gcggaatggg tggaggctct cgggattgtccaggcaggag

92941 gagtccatgt aggactctgg acctggccaa cctgcaggct gaggaggagaaggagaagaa

93001 gaagaagaag aagggcactg cggaggagcc agaggaggag gagccagacgagagcatgct

93061 ggactggtgg tccaagtact ttgcctccat tgacaccatg aaggaggtgagacctcgggt

93121 agggtgaggg gaggtgaccc cctccacact cagaccctcc tgtccagcttctttcccacg

93181 gcccccaaga gctggatccc aactccattc atgtgagttt gggatggttttgtctcacat

93241 ccttgaaatc ctagctcaga actcaccttc caagatgatg gtcccatctaccttccctgc

93301 ttggttttct tttgtcctca ttgactcatt ccacaaatgc ctcttgggtatatgcgatga

93361 gccaggctcc atactaggtg ctatgggagc caaaagatgc cacacctgccctgatgggcc

93421 tccggtttac tgggcaaaat ggacatgtaa acagagactt agagaggactatgtgataac

93481 aaaggcaaat catggcttgg gggaatcagg gaaggcgtct cagaggaggtgacctttgtg

93541 gaaaaggaga aacatgttct cagaggccat aagggaacaa ctgcttatcagtagtcctta

93601 cgactcttct tcataatgtt ttattttaca catcttggtc atcggcacgtgaatgattct

93661 tcccctatta cacatatgtg ggttccatct gtttggccag attgcaagttccagaaagcg

93721 catttctctg ctttcttgtt tgtgtcctct ccacgctgcc tacctagctcagggtgctct

93781 gactggccac ctgaccagga gggacacatg cctgcagttg tgtttcctcagtggggccag

93841 agctgatcca gccacatcct ctcccaggcc ctttctgtga cccaagctaggtgtgatatt

93901 tattagagca cacattaagc tgctgtagca agttagagtg aagtgaacaagacagcagtt

93961 tatttctcac ataacatctc agagagtggg ggttaggctg gtatggtggctcagtggtgt

94021 caaggactaa gatcctgacc tcttgtttgt cacatctgta aggttggaggtgactcaaca

94081 tcatgttcta attcaagtgc acaggaaggg ttaaagagga gatgaggcatatgcttttct

94141 ttttcagggc ccaatccaga agctgcacat atgacttcca ctcacattgatcagaatcta

94201 gtcccttagc tacacttatc tgcaaaggag gctgggaaat gtaatctttcacaaggtggc

94261 tgtgtgctca gcaaaacttg taaaaatagg agaacagatc attgaggacaactggtagtc

94321 tcgtctccca ccatcaagtt ggccaggctg gagctgcaag aggctgcctgttgtcgtctc

94381 tactcctgca attttcacag actgccacca ggtggcggtg gcgacttagttgaaacctgg

94441 tttctagttt ctagtaagat ttattctcgt ttccagtaag atggggtgtgctgagtgaaa

94501 gaaaatatag tacattttct tactgttata cttttgtaca ttaaaacaatttattaatat

94561 cactaaaagc aacattaaaa tgcactgtac ttttttaagt agaaaatgtaaatatttatt

94621 gcaaggtgtt atttcttttt tttttaaatt atactttaag ttctagggtacatgtgcaca

94681 atgtgcaggt ttgttacata tgtatgcatg tgccatgttg gtgtgctacacccattaact

94741 cgtcatttac agtgggtatt gctcctaatg ctatccctcc cctctcccccagcaccacca

94801 caggccccgg tgtgtgatgt tcccctccct gtgtccaagt gttctcattgttcagttccc

94861 tcccatgagt gagaacatgc agtgtttggt tttctgtcct tgtgacagtttcttcagaat

94921 gatggtttct ggcttcatcc atgtccctgc aaaggacatg aactcatccttttttatggc

94981 tgcatagtat tccatggtgt atatgtgcca cagatgcata aacccctaagtaccactagt

95041 cacactgtac acattataaa ctttttttaa cccacttaag cagagcacatggtggacttg

95101 aaatgcagta gggaagattt tctacttcta gtgcattaag actggtctgggcccacaatt

95161 tggggtcaac agactcctcc ccaggaaacc caccttctgt ccttttcatctcatcttttg

95221 gcagcaactt cgacaacaag agccctctgg aattgacttg gaggagaaggaggaagtgga

95281 caataccgag ggtgagccct ggaacctgga actctgcctc ctcctccccgcccctgggtg

95341 gtcagctctc ctgcccacct catcacctgc ttctcttttc cctcctgccagccctcccag

95401 ccttagtagc cagggaagca gcatcagtaa tccatgggca gtactgggcaggctaaggcc

95461 cttgtccagg gaggctttta ctctgaccag ttcagcaccc acagtgatgggcagacattt

95521 agagccacag aacatcagag ctagaaggga cctcagagct cattccatccagcattttcc

95581 agactctttt ccatgaagaa aattgatgga tgttctagaa ggaacaaattagttttggtc

95641 aaattagttt aggaaaagct gattgaaaca gcttgttttg gtgcaggacttttcataccc

95701 tttactgtgc aaatgttatt atacatctct aaaaggaaga cacagtataaaatatttccc

95761 cagcttattg gatcacagta ccctttcttc taaagcatgc cagcagcatctgcaccaggt

95821 gctccactga atgaggtttg ggaaatgcta atacagagtg ttattattatggacaagaag

95881 agggaagcta gtgaggaaag tgagtgggca aggaactgcg cagcaacaggcctccacccc

95941 caaacccatg ctccttcctg cccctctctt ccaaagggca tgaagacagtcttcagacac

96001 cttcccgggc ataaacccac tggggccccc agcacctcca tgaggcgggcatgctaggga

96061 gtattatctg catttgacag cacatggaca tccgagagtt aagttagtaaagcaaattag

96121 cgacagagct gggtctcgaa tccaggcctt cctgctctgc tcatttctgctccacctcct

96181 tttctgcttc tggccaggcc tgaaggggtc aatgaagggc aaggagaaggcaagggctgc

96241 caaagaggag aagaagaaga aaactcagag ctctggctct ggccaggggtccgaggcccc

96301 cgagaagaag aaacccaaga ttgatgagct taaggtgaga gcctaggagcagacccttct

96361 agggtgtgtg ggggcgggaa gaggggggcg cagtgatcct gcaggtggggcaggacaaaa

96421 gccagagacc aggcagccgc cccctaacag cctggtctgt ctcaggtataccccaaagag

96481 ctggagtccg agtttgataa ctttgaggac tggctgcaca ctttcaacttgcttcggggc

96541 aagaccgggg atgatgagga tggctccacc gaggaggagc gcattgtgggacgcttcaag

96601 gtcaggccag gagcacgggc ccagcctgag cacccgccag cccttgccccccccacaggt

96661 tcccccactc acctcccacc actgccccgg ccactgcctc cagaagccctggactctccc

96721 atgactcagc agttaaaggg tgaaggccct gccacatcag ggtccagccctcctggtgct

96781 gttagctatt ttgaatgcca cccttgccag gcaaacctac accctgacccacatttgtct

96841 tgcccagggc tccctctgcg tgtacaaagt gccactccca gaggacgtgtcccgggaagc

96901 cggctacgac tccacctacg gcatgttcca gggcatcccg agcaatgaccccatcaatgt

96961 gctggtccga gtctatgtgg tccgggtgag actcccgtcg ctttccctccttgcaagtct

97021 cctcatcctc ccatctggga gagagcaaag aagctgcata ctggccaggtgcaatggttt

97081 acgcctgtaa tcccagcact ttgggaggcc aaggcaggag gatcacctgaggtcaggagt

97141 tcgagaccag cctggccaac atggttaaac cccgtctcta ctaaaaatacaaaaattagc

97201 caggcacagt gccacgcacc tgtaatccca gctactgagg aggctgaggcaggaaaatcg

97261 cttgaacctg ggaggtggag cttgcagtga gctgagatca cgtcattgcactccagcctg

97321 ggagacagag cgagactctg tctcaaagga aaaaaaaaag aagaagaagctgcatactga

97381 cagccccaga ctgggaggca ccagggagat catttggtct agtctttatcttttctagag

97441 gaagaagtca acgcccagag aggggtagcc acttgcctag ggtcacacagcaagcctcct

97501 gaggggtcca gtgctcctgc ccctgccctt cactgtcata ggaccctcaggcagcctggc

97561 aggggcactg aagatgagca gggcatggga gcctgctcag gcagcccttctccccattcc

97621 aggccacgga cctgcaccct gctgacatca acggcaaagctgacccctacatcgccatcc

97681 ggctaggcaa gactgacatc cgcgacaagg agaactacat ctccaagcagctcaaccctg

97741 tctttgggaa gtaaggcttc ttggtgccct cccctgccac acccctacttctccaaccca

97801 gaacacctcc caccctagcc aatccttaag cccttctcct aactccaccccaccaggtcc

97861 tttgacatcg aggcctcctt ccccatggaa tccatgctga cggtggctgtgtatgactgg

97921 gacctggtgg gcactgatga cctcattggg gaaaccaaga tcgacctggagaaccgcttc

97981 tacagcaagc accgcgccac ctgcggcatc gcccagacct actccacgtatgtggggcat

98041 ggggcagagg gcgggggcag tgtgcctgct ttgcctccac tctaaaatgagattcagatc

98101 ctggtgattt gagaggttag acattgtggt ttctgtccca ggccaggcctctgcccctac

98161 agtccctggg cacagtcttc aggggacagg actgcagatc ccaaaacaaggagagggaca

98221 gtggattcca ggacagagga ggcaggacga ggagagacaa gtgggctagggaaggtgggg

98281 gctagcaaga ggaggacaga aagagtcccc tggggatctg ggccagctctgccacttata

98341 ggctgtgtga ccctggccaa gtcccttcac ctctctggtt ttcagtttcctcatgggagt

98401 ctctgaggtt ccagaggagt gggcacagtg aggggatgca gtggggctaggctggggaca

98461 ctgatatgtg gtccaaggcc cagggcagga aggttcagcc tccagcagccctagtgtctc

98521 aggtgagcct ggggcccagg gcaggaggaa tcaggctcac ttgctgatgagggcaacagc

98581 caactttaga gaactggcca cgaccagctg tcatccagga tggcttagtcccacccagcc

98641 cctccaagcc tgtgtgtccc ctcccacaga catggctaca atatctggcgggaccccatg

98701 aagcccagcc agatcctgac ccgcctctgc aaagacggca aagtggacggcccccacttt

98761 gggccccctg ggagagtgaa ggtggccaac cgcgtcttca ctgggccctctgagattgag

98821 gacgagaacg gtaatggggc actggatgca gccgcctgcc ccctctccagggggtttcag

98881 aggccaggag gggcccacac ttccctgggg aacctcacag cctagcctggggtgtcctca

98941 gcctaaacct ggtcttagtg accctctgct catcacccca gagccccgttcctgtctgcc

99001 cagcctctgt gcttccaccc ctcctacagg gcagccccac ctgctttctctctgtccaaa

99061 tcccagtgag gtagagaggc tatctgcatc ccattctgca gataaacaaaccaagatcct

99121 acttctagtg actcgcccaa ggtcatgtgg ctctttagag gcagagcgagggcatcggcc

99181 caggtccatc tggctctaat ccttaaactc tccttacttc tctgtccatgaggcacttcc

99241 cagagaagca gagaattggg aggtgtctgt gctggtatct gatcactttcaggtgctggg

99301 acaggaagtg gattctcccc tccctgaccc ttctctcagc ccagcagggctctccagtca

99361 acttccccaa gcagaggacc aagggcacag acctctcttg gccctgtggggcagctgaga

99421 ccctgggcaa gccacttctc cttctgtgcc tcagtttccc caacagtgaaaaggaggtgg

99481 ggtagacagg tgatggcata gaggcttctt tgtgctccta agtccctagtcccagcaaag

99541 gtcttctggt tctgctgagc catgtgtgca gctgagccgc cggcacccacaggtcagagg

99601 aagcccacag acgagcatgt ggcgctgttg gccctgaggc actgggaggacatcccccgc

99661 gcaggctgcc gcctggtgcc agagcatgtg gagacgaggc cgctgctcaaccccgacaag

99721 ccgggcatcg agcaggtgac acttgcatgg ccaagactgg ggttcttgggtattggggac

99781 cagggatccc caacctgagt cagtaaaggt agaagccagg cctcacgctgtccgctgcat

99841 tccagaaagc ctggcaggca ccttcccacc aaggcccctc agggtaacttgaatggcaag

99901 ggtctttgct ttgagtgaga attacatcag ctcaggcaga gacctgggttgtctccctca

99961 gaagctgtga ttggctattg gtgacatcat aggaattcct ggcatccaaagatggaaact

100021 gatgaactgg gtccttgaca gaacaaaggt taggagggag aggagagctgatcttcctgg 100081 gcagagggag aaggccctgg gagatctgcc acaaccctct tcctcagggccgcctggagc 100141 tgtgggtgga catgttcccc atggacatgc cagcccctgg gacgcctctggacatctcac 100201 ctcggaagcc caagaagtga gcggcctggg gcccagcgct actcccttccggcccacccc 100261 acccacttcc caccacggcc caacccttcc tgcggggggc tcaggtccagatggccttgg 100321 ccagttggca tccctggggc ctgggtgtgg ccactgggcc ttataggggagaaactgacc 100381 aaccaatcga tagagtttag ggcctgccct ggagagtccc cacgtgctaaggcaggacaa 100441 cgccttccac cctgcatcag tgagcgagac aagccccaca cagcacactccggtgcattg 100501 tatctacacg gtctacgcgc ccatacacat gcatctcatg cacacacacacacacagcat 100561 agcactccca cggacaccca cacacatgcc cacactgacg cactccttcacaacacacag 100621 aacccctggg agccggccct gcgtcatcct cacatccagg ctagtgtgatgttccgccaa 100681 gttttctttg gagtgcctgc cagtgatgaa tccaggagtg agtgcctggaagaggcagga 100741 ggtggtagag tgaaaagaac ccgggtttcc catccataaa gcggcaggttcaagtccagc 100801 tgtcagacag tgactggatt cagggccagc ttcagggatg gaggaagccacacagggtcc 100861 cactcttgtt tccatgctcc tatgttgcca tcttgaaatt ctttatgacaagtgaccctg 100921 catttccatt tggcgctggc cccagcaaat catgcagcaa attctgccaggaatgtcctg 100981 gaaacctgag gccatgagtc agctgttcca gggcctgtca ttagggggcacccaactcac 101041 tgggccactc tgggctcgca gccctgtctg caatcccagg agagccatgctcagatcaat 101101 ttttagtgaa tgactcagcc tcactcttaa tgattgaaat gaactacatcattcataatt 101161 acaattaaac cttgagggga aaatcctctt tggggacagg gacatacagcttccatgggc 101221 ttccattgct ggctactggg cttaaatgca gacttctctt ggaactagcatctgagacag 101281 agggtggctt cctcccctca ccccaccccc accgcccaca gccatgtgcctggtgggcct 101341 tctcactcat gcctctgctc ccccaacccc aaaccactcc tccagccccagcctggccca 101401 ggccctgtgc tgaccccaag accccagggc ttctctccgc ctgccccatcccagccctgg 101461 caccctggca taacccccac ctggggctgc taaccagcct tctctccctgggcccaggta 101521 cgagctgcgg gtcatcatct ggaacacaga tgaggtggtc ttggaggacgacgacttctt 101581 cacaggggag aagtccagtg acatcttcgt gagggggtgg gtgagcagtccctgcatggg 101641 agggactgag ctgggtgggg cttgcttccc ggggggcagg agaggaggcagagggaaggt 101701 ggctgtgggt gggagaggcc ccaccagcct ggctgcgggt ctggagatgtggcgcccaca 101761 ggtggctgaa gggccagcag gaggacaagc aggacacaga cgtccactaccactccctca 101821 ctggcgaggg caacttcaac tggcgctacc tgttcccctt cgactacctggcggcggagg 101881 agaagatcgt catctccaag aaggagtcca tgttctcctg ggacgagaccgagtacaaga 101941 tccccgcgcg gctcaccctg cagatctggg atgcggacca cttctccgctgacgacttcc 102001 tgggtgcaga gcagggcagg gatgggggtt caggatccag aactgagaagaggcaggggc 102061 cgggttggcg gggacaggga gagccctgcc ttggggggac aaggggtcattgcttccagt 102121 ccatcagagc caggggtgtc cgacggggtt ccgcccccaa ggacccacctaaccgtccct 102181 aggcagatgt tctcagtgtc ataaccaggc tgacaacaag ctttggacacaccaaggagg 102241 gggcagtcag tgatgatggg ggaggggaga ggctccctaa gggagtcgggaaacctccct 102301 gggcctcagg ttgcttctct gtaaagcagg gattctccct aaaactctaatctgcatctg 102361 caaaagcttg tgggattagc aggactttga cagaatggat gcatggcagggagtggcagg 102421 ggagacccca ggagagaccc tctggggtga aagaaggacc tgagtaaagcatgggggctg 102481 gggctgccta gcaagcccac gaggatgcct gcattgaggc cagttgctgggagtgaggca102541 ggaggatgag atgtgggctc agggaggtct gcactcagca aacaaggggccgaggagccc 102601 agacccccac ccccaccccg ccccacccca gccctgttca ctctgagctgacactgaggt 102661 tgccacaggg gccatcgagc tggacctgaa ccggttcccg cggggcgcaaagacagccaa 102721 gcagtgcacc atggagatgg ccaccgggga ggtggacgtg cccctcgtgtccatcttcaa 102781 gcaaaagcgc gtcaaaggct ggtggcccct cctggcccgc aatgagaacgatgagtttga 102841 gctcacggtg cgcacccctt cctgctcggg cagtaggcag ggctgggactggctggggtg 102901 ccaagggccc agcacgcagc ctggacgctg ggacctgtct gtcctctgcagggcaaggtg 102961 gaggctgagc tgcatttact gacagcagag gaggcagaga agaacccagtgggcctggcc 103021 cgcaatgaac ctgaccccct agagaaaccc aagtgagtgc cctgccggcccagcccctcc 103081 ccactctggc tcttggaggc gctggaacag gaaggagacg atccccagacaccccatctc 103141 ttcctgggcc acagcctcat tacaggggag cctcctccct gccctctgccaaccctgaat 103201 cccacaacgt ccctttgaac cagaggatgg gctaggaata ctggagagcaggaccttccc 103261 tgggaaaggc cccatctagc ggagagaaac tatgctcttc ccttcctagcttttgcagaa 103321 gagccagctc cagtggtggc ctctggggcc atggccagcc ttgatggccagaggggtgcc 103381 tagaactgca cacacagccc aggacagctt ccctcttggt cttggcccctcgccacaccc 103441 aatcccttct cctccctgtc cctcctctgc gctctctacc cttcatactccagccggccc 103501 gacacgagct tcatctggtt cctgaaccct ctcaagtcgg ctcgctacttcttgtggcac 103561 acgtatcgct ggctgctcct caaactgttg ctgctcctgc tgctgctcctcctcctcgcc 103621 ctgttcctct actctgtgcc tggctacctg gtcaagaaaa tcctcggggcctgagcccag 103681 tggcctcctg ggtctgatat ttcttacttc ttcctctgga ccaagggctaggcaggcgcg 103741 tgcacacaca cacatataca cgcacacatc cacaaacaca aatatgcatacatgtgcaca 103801 caaacacaca caagcatgta tgcacacatg tgccacgcac aagtgcatacacatgcactc 103861 aagcacacac aggcacacac ttaagcccac acaaacatgc acagcaactttcaagctttc 103921 atgacagaat agactctcag aactagaaat gactatttta cacttttccacattaagcca 103981 aagaggtgaa gtagcttgct caaggttacc cagcaaatta gggtagagccgggactcaag 104041 ccaaggtttc caaatttcca atcctgtgtt ctttgcacac cacctctgctcccagccatg 104101 tttctcccag actgtaaccc aatttttttt tttttttttt ttttttggagacagagtctc 104161 gctctgtcgc ccaggctaga gtgcagtggc acaatcttgg ctcactgccagctccgcctc 104221 ccgggttcac gccattctcc tgcctcagcc tcctgagtag ctgggactacaggcacccgc 104281 caccacgcct ggataatttt ttgtattttt agtagagacg gggtttcactgtgttagcca 104341 ggatggtctc gatctcctga cctcgtgatc cgcccatctc ggcctcccaaagtgctggga 104401 ttacaggcgt gagccaccgc gcccagccga ctctaaccca atttcattggcagaaagaag 104461 ctgagctatg gacagggaaa agggaagggt gtggccaggg ttagccaacaggtctggaaa 104521 tggctctcac ccgtgtgtga cctcccagtc cagggctgtt gttttctgcccttcaggata 104581 ataattccat tcaactcaaa catttcatag ccaccatggc ctgaacacccaactgcaggt 104641 gctcagagct ccccaggcac tggctcactg tgccattgcg ccaaacccaggaggtaggta 104701 ctgcttgtaa ccccatttta tacatgaaga aaccgaggtt gatagaggtgcctcacttgc 104761 ctgtgaaaac cattcaaaac caggtgccct gcacccaagc cccggctctgtgtccccacc 104821 aatactgagc tcagctctgg ggctgcacgc catgtcctct gggaggcagtagtttgaaaa 104881 tgcatatgca gtactttcac ttgtatcttg acattttaca aaacctattgtttttataac 104941 acaaacgaca gatagtgagg ctggccaggt gcttctcggc tgggaggctctacagaaggt 105001 ggagtgggtc ttcatcctga gagtgggcag gtcggtgagg gcagcttgcaccccacaggg 105061 gctgctcaga ccctcagcag ggcccggtgg gaacagccat ttatgtccatcagaaaggaa 105121 gaggttgtga agcaccagtc ttaccaagga cgtggggcag cacatagaacgagctaaccg 105181 caggagcttc ctaacgatga gaactgcctg cagggccaag gctgccccatgctgcaagta 105241 gctcccatct aggccttagg aggagattcg ggccccaaag gtgctgcagggaggatagag 105301 ttttgtaagc agcaagtcgg gtacttagaa atgggtttaa accctggctccagcattcac 105361 tgcttttggg gctggggcca tggcagggct tttgggggtc cagaaggacagaggatgggg 105421 tgcactggga ggcagctcct gcccactggc tgaccggctc ctctcttccacttcccagcc 105481 ggcccgacac ggccttcgtc tggttcctca accctctcaa gtccatcaagtacctcatct 105541 gcacccggta caagtggctc atcatcaaga tcgtgctggc gctgttggggctgctcatgt 105601 tggggctctt cctctacagc ctccctggct acatggtcaa aaagctccttggggcatgaa 105661 ggccgccagc tcccgccagc cgctccccag ccctgccgca tttcctttcagtggcttgga 105721 ctctttccca tctcccctgg ggagcctgag gagcccagcg tccactcttcatgccttggg 105781 ccgagcctgc ctcctgcttg cgggggccgc ctgtcctcac tgccccaggctgcggcttgc 105841 ccagtcccgc ccctctgacc cctgcctgtg ggctggggag ccttggatggggtggggacc 105901 tggaatgggt ctctcttgcc ccacctggct gaggcgccac ccttcttcaggcccaggctc 105961 cagaggaaga ctcctgaaac cctccccagg tcttccaagt acaggattgaagctttagtg 106021 aaattaacca aggaccatgg gtcagtgccc agggctttaa aaagaatgaacgagcaaaag 106081 gtatccccgc cgtgacccct gcagatagca ccggtctttg atccgcagcaggggccagac 106141 cctgcccaca agtcccagcg cggctgcttc tgccactgct gggctccacttggctcctct 106201 cacttcccag ggggtcgcct gtcctgcctg tgggtttcca tggcttcccagagctccctc 106261 tgccccagcc agcgcctcca ggcccagctg aggagctgtg agaagcagcagaggggactc 106321 cccatcccgg gcacaccctg tcctcccacc cctgccccct tgcccttccagccctttcag 106381 ctgcagctgg gagctggccc gtcaagtgct gcccctgcct gtgtctgggtttctgttggc 106441 tgtttttctt ttcttgagtg gtgatttttc tctaaataaa agaagtcaagcactgagctg 106501 acaggtctgc actggtcaag ctgagaggag cagccgcagg tgcggggcagaggcagcagt 106561 tctctaggct ggcagattca gtaccagcag ggctcccatg gcctttccccttcaagtggc 106621 ctctggtggc ccagggttca aggcaggcct caggcacagg gctgcccacccaggctgccc 106681 acaggaggag tcttacacca tagcccaaag ggcacaccag cctgggcccaggggccccca 106741 aagcaccgaa agaatccttc aggtctgggg ccagtctgaa ggcttaaggccccacaaggg 106801 cccaaaagct ctagcctcca cccacagaaa ccagttcccc tgaaagcaagaaaggagccc 106861 cacgctactg gcctcggcct ctgactcaca ccactatctg agcctggggcaaagtcccct 106921 catgacacag aggtaggggc aagggcctgg tcttgctaga cctgacctctttaaagagat 106981 tcagccacaa ctttaaaagg ctttaatcat aatgcaggac acaggtaactcctctggctc 107041 cttatttcga caggctataa agacagccct ggaaaatcca gagagcaggcccaggtgcgg 107101 cccagtgggt gatatgagct ggctccggca cagacaccag catcaggccagccctaacac 107161 atcagccttt ggcggtccag ctcattttgt gggtacccgc aacacctgagtgggaggaac 107221 ttgcagttca gagttgatct ggaaaagaaa gggtgaaagt cgttacatttttcccagggc 107281 cctccttctt tgccaccctt gcgagccacg ctggctctcc catgggcctccaaagccctg 107341 cacgcatctc ctctccaaag ctgagagatg ctgaacaccc acagactgcctccctgcagg 107401 agacacgcct gagccttctt gctcagcttc tgctccagct gtgacctctggtagcgttct 107461 tcatctcccg cccgtccatt ctctgcagtc ttcccctctc ctctctccacgcacccatgc 107521 catccccaat ctagcctgcc ccacctcttc ctcccccagc ctcttgtatacagtagcatc 107581 tgtggaagcg ggaaccatac cgtccagaat gtctgggtcc tgtcacaggccaagggtcat 107641 tatgaggcca aggttcacta caacatccca ctttcagctg tggcctgggacctgggactg 107701 tgctggggcc acgcagcccc tgtggctgga cttggagctg gcctcagtcacctcacacgt 107761 gtgcaactaa cagctgcgtc acgaccttcc tggcctacag ccccagctgcaggtgcccac 107821 acccgcagag caggaaatgt cagcaatgga ctttttcctt cctcctcttgccaggccatg 107881 gggaagttgt ccacaactat tgcagggttg ggcacagatg ggggccagggaatatctgcc 107941 ccagcagagc ctccttcccc atgcgaggat gaccctccag tcatatcccaggcagggaac 108001 cggggctggt gggtggaaag agcccaggct ctggacgagt tgcaaactctgcaagttgtg 108061 attgtccttt gtgtgaaatg aggagcattg tttccgccct gtccacctcacacagcgggt 108121 gtgaggatgg aagaagagag cacagctgga ggctctgtag ctggggagctgctcctggct 108181 gtggcactgc ttcacacaga gcagtcccag ctggccactg gcaccagaaaccacagtatc 108241 aaagagacac tgtcacacct gagctgtcct ggaggagact tcaggcaagatctactcctt 108301 tggccagtag ttgtctcaag gtgccactct tgatttttta catcatatcacaaagctccc 108361 ttgcctctga cggggagggg actcctcgtt ccctaatccc agctccagtgcccctgcccc 108421 acccgtgtct cccgctgccc ctccttggaa ggccccgccg cccaccttggagttcagata 108481 ctgctgcagt agcgcc

Norrin胱氨酸结生长因子(NDP)

NDP基因编码“norrin胱氨酸结生长因子”(NDP)。人ND基因位于染色体Xp11.3上。其包含3个外显子，涵盖约千碱基(kb)(NCBI登录号NG_009832.1)。NDP编码分泌的norrin蛋白，所述蛋白在通过(FZDA)和(LRP5)共受体的Wnt信号传导路径的视网膜血管生成中发挥作用。NDP中的突变与诺里病(Norrie disease)假性神经胶质瘤(一种特征在于儿童早期视网膜病变的X连锁隐性综合征性听力损失)相关联。约有三分之一的诺里病患者会发展为进行性听力损失，超过一半的人会经历运动技能的发育迟缓。

NDP基因中的各种突变与听力损失(例如，诺里病假性神经胶质瘤)相关联。例如，p.His4ArgfsX21、p.Asp23GlufsX9、p.Arg38Cys、p.Ile48ValfsX55、p.His50Asp、p.Ser57*、p.Cys93Arg、p.Lys104Gln、p.Gly113Asp、p.Arg121Gln和p.Cys126Arg突变各自均与诺里病假性神经胶质瘤相关联。参见，例如，Musada等人，Mol.Vis.22:491-502,2016；Chamney等人，Eye(Lond)25(12):1658,2011；Liu等人，J Chin.Med.Assoc.79(11):633-638,2016；和Parzefall等人，Audiol.Neurootol.19(3):203-209,2014。

检测基因中的突变的方法是本领域公知的。此类技术的非限制性实例包括：实时聚合酶链式反应(RT-PCR)、PCR、测序、Southern印迹和Northern印迹。

示例性人野生型NDP蛋白为或包括SEQ ID NO:20、SEQ ID NO:21、SEQ ID NO:25、SEQ ID NO:26或SEQ ID NO:27的序列。编码野生型NDP蛋白的核酸的非限制性实例为或包括SEQ ID NO:21、SEQ ID NO:22或SEQ ID NO:24。如本领域中可以理解的，可对SEQ ID NO:21、SEQ ID NO:22或SEQ ID NO:24中的至少一些或全部密码子进行密码子优化以允许在非人类哺乳动物中的最佳表达。

人成熟NDP蛋白(SEQ ID NO:20)(NCBI登录号NP_000257.1)

MKTDSSFIMDSDPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECNS

人成熟NDP cDNA(SEQ ID NO:21)

atgaaaacggacagctcattcataatggactcggaccctcgacgctgcatgaggcaccactatgtggattctatcagtcacccattgtacaagtgtagctcaaagatggtgctcctggccaggtgcgaggggcactgcagccaggcgtcacgctccgagcctttggtgtcgttcagcactgtcctcaagcaacccttccgttcctcctgtcactgctgccggccccagacttccaagctgaaggcactgcggctgcgatgctcagggggcatgcgactcactgccacctaccggtacatcctctcctgtcactgcgaggaatgcaattcc

人野生型NDP基因组DNA序列的非限制性实例是SEQ ID NO:22。SEQ ID NO:22中的外显子是：核苷酸位置1-87(外显子1)；核苷酸位置88-468(外显子2)和核苷酸位置469-1719(外显子3)。

人NDP基因序列(SEQ ID NO:22)(NCBI参考序列：NG_009832.1)

1 aagatgctcc gtggaaggga gccgagcggt gggcagaggc tgagtccccg ataacgagcg

61 cctcacattt ccgtggcatt cccatttgct agtgcgctgc tgcggccgca cgcctgattg

121 atatatgact gcaatggcac ttttccattt gacattctct ctctctctct ccctctctct

181 ctctccctct ctctctccct ctctctctct ccctgtgtcg cttaaacaac agtcctaact

241 tttgtgtgtt gcaaatataa aaggcaagcc atgtgacaga gggacagaag aacaaaagca

301 tttggaagta acaggacctc tttctagctc tcagaaaagt ctgagaagaa aggagccctg

361 cgttccccta aggtaagcag gaaaacaagc gctgccggct tgcctaggaa atcgcttctt

421 tccaaaccga gcatttcatc ctcctctcag acaaagagac aacctttaaa taccacttaa

481 atttgcatta ctttaatttg cattaatctg tagcatgcta gcattgtgtt tcttaaatga

541 acgggtcttt gaagtctgtg acagagcagg gagcctccta gaaaagcttg aaaatatctt

601 ttggtttgac ttaaagagat ttttcttttc aaactctctg cgtagttaga tgtaactttg

661 tgatggttct tatagttgac cccgtgaaag ggggctgcga agcagcaact tgccaacatg

721 gattcatgga gcccagtatc ttccccagca ccctcatccc acttacaatg ggggcactat

781 taacgcaggc aagactgcga gtttaaaagc gcactgttta cttttattac tacttatgta

841 tgctgctgat ctcctgccag ggctctgccg gagtgctcag aatgacttca aacaataggc

901 aacatttatt tctagctttc tgtgtcacgc tttgcaggaa tcctgctccc ttgcactctt

961 ctttcagcgt gcaggtcttc gcttccatag atgcattggg gagcaccggg aggagatgag

1021 gatggattta ctgtatgatt ttgattgggc aaaaagtccg aggaaatgcatgctgtttgc

1081 cttggactta ttgcaggggg ttatttttag tcatcagctc gtccctgcagcatgatgttc

1141 aaggagtgac cgggaaagga tgctcccacc agcacagaga ccaggacctgtaggaatgac

1201 tcctacctgc gggatattcc gaggtttctt tcaaactttg gaatacaagttctctcttta

1261 aatgaacaat tgagctgtag gaggcctggg cataactctt tcttgggggacgggaagttt

1321 gattgtgtac agaatgttaa tgactcagaa cgcccagtaa ctgaggctcattgtaataga

1381 caaacccaga taagcctcca tgagaggcag actcccatct ttactgagattcaggtgcgg

1441 gaaaggaagc tatttggcaa gatgggagtc ccttgtacag ttctttgtaactcattaata

1501 acagatatgg ctgctgtgaa acatgtctct tttcatttct aatattagtgtattttaatt

1561 acaaggagct ggcattggca aattacccca acacataaga ttaaataccaggtgcatttg

1621 aaaacagaga gatgactgaa atggggagtt gctgtgggtg tcaaccaaatacagcgggga

1681 cggcacaatg cttctcaact gagcgtttaa accagatgca aatatctgctcattttcttc

1741 tcatcagtct tactaattca aggaaacttt atggtcctgt ttgccagttttcattgcaaa

1801 ttggtacaca gtttatgcaa aacttttctg attttctctg ataaccagcccaataagcat

1861 cgctgaatga aaatctgata tttgaatagg ttaatttaca actttggggtattcattagt

1921 caagaaagcc ataaaagaca ctatggattc cattgctgta aaattttattgtaatttttt

1981 tttaaaaaaa ctgcggttag caaagcattt agctgaatca aaacaattttcttagactat

2041 tattcagatc attacatgag agtatttgaa cacaaaatgc aatgttttgcatcatttatt

2101 ttaaaataca tttggttcag gtaacgggag aactggctga ggccttcttacgactgtgta

2161 ccaagcagct gacacccaca gatggaaatg tgcctgtgga gttttcaatcttaattcgag

2221 ttccaatgac actgtcaagg gaaaaataaa tcatttttca atacatttaacaatttccaa

2281 ctcatttatt ttcctgggcc cttgaaaaat gtggtgagtt tcttggaattatagccacca

2341 atggtggcca gcaatcttta ttttaagaac tcacaattca agtactattattctctggtt

2401 aattatttat ttcatcaatt tttaaataaa tatttattaa gcattttctagatgcccagt

2461 gctatgctag tcccgatgga tgcaaaggtg aatgagacat tgtcccatactctaattctc

2521 agtccatatg ccatctctag ttagattttg gaactgaaat gggcattgccaatgggtaaa

2581 gtgggcaata actttcctgt tataaagaat tatttaaaac agctactggtttctagattt

2641 acttgaaatg attctcactc atcagtgggt tttctttcca tttatgattaagggattccc

2701 ctttggcctt tttcaccaga tcctgggtac acgtcatttg cacagctaacacggctagat

2761 ctttccagcc tgggtagaag aatcccggaa aaagacagta gtttatcctttctctgctct

2821 cctgagcacc ctgtggaaag gaccatatgc tgtctctatt ggggatgggtgtgagtcgcc

2881 tactcagtag ctaacatcag ggccacttga tgaatcatcg aattagaaacatgcatatgg

2941 aggaagatgc agtcactatc cctcaccact tacttgtccc acccccagtatcaaaacaaa

3001 tgacctctgg gcctggccta aattcaagag gcccctggga agaagctgttggaaactctt

3061 ccccaaaccc aggtctccat catagccaca cagtgttgct ttcaaataacccagtatggt

3121 gttttatcac gtgtttaggt tactggggga aaaaaaaaac cctgaaaacagcatcaccag

3181 ggtccttgac ttggtcctta tcagcagata atcccccgtg gttggattaaaatgcctctg

3241 actccctggg gtgcctgact caccctagcc agccctcagc ttcttggccagcggccttcg

3301 agcccatcct cacctcttcc catgacggcc agtgactgct tctttgcccaggccctctgc

3361 actaggccag cagccagtgg gagcagaggg gatgggaagg caggtggacagactgtgaag

3421 tgctaaggca gagcggggaa gcagggctgt gagacagggt gggtgagctccagggcctgg

3481 gttgctgtgg cctgccctgg ctgtgatcag ctgtcatttc ctctttgtgtatgacactgt

3541 ggaacatatt aaaatttctc tgggatggta tgtttggaat tcctctgatgccccacctca

3601 ccaacttacc cggacaataa aagcaaggtt gtaagccttt gaacagctggctggctatat

3661 atttcccttc tttctttcgc ataatctaat tcagaaaaga atccagctagactggcagtg

3721 ccatgtctgg gtacttgttt cctgcaagtc cttcctcctc cacctcctcccgccagtcct

3781 ggaatcttcc tgggtggcat gtggcttttc ttttcttttg ctcaccactgctcccagccc

3841 gccccctttt cccttcgcct gagctccttc ctttgtcagc tggctctttgctctgcctgt

3901 tttccagaca gcttgggtcc tgttccatcc ggggagaaca gcccatgggatctccccatc

3961 tccatagtat tcccaggatg tcattcttgg caccagctct gccgggctgataggactggg

4021 gggctttttg tagtcccgag cctgaatcca ctcacagaga ggagcagccacatggcttag

4081 ctgccctttg ggctgccgag agcggggctg gagtgaccgg gttggcaggaacgagcatac

4141 catcacagtg acccgaacat ctccggcaaa ggccttgggg tgggagcgctatgggaatgc

4201 ctggatgcac ttcggcctac attaagagaa atgtggttat tctctgtttcgggggagaga

4261 caagcggctt gaaacaaagc cctctggatc cttggcccct tccctgccccctttcccggt

4321 ctgtccttcc cacatccctc cctccccaaa cagaaagaaa gagagacaggacttctaatt

4381 tggccagcac agacccgaat gtctttatga aacccattta gtgaaagaaagaggggagaa

4441 atatattctg ggttgatccg aactaaaaaa tgcatggggc tttggagatggggcgggatt

4501 ttttctttct ttctttctgt ctcttaagag cagaacaaca gtttcgttgatgagttgcaa

4561 atggaaggaa gtggacctct caattagaga ttcccattta agagcctcaatgtaaacctc

4621 cctgtgacat ccttaaaaga tgctgctaat gtccctggga ccaaaaggtattaaacagca

4681 agccaccagg cggcttccta ttccttttct ttttctgggg gctttggtcgtctttttcaa

4741 attagctaaa attcattaaa ggacccaaaa ggaaaaattt aaagcagctgaattaaaatg

4801 agtctttccc tgttagcctg acaagaagaa aaaaagaaag gaagaaagggaaagaaagag

4861 aagaaagaac caattcccct ccactaccac ttcttgggtt ttaatatgaattattccata

4921 caagtcccta ggctagagga tctatttaaa gacgcctggc agcatgaagggagagggtaa

4981 aaatacaacc actcttttgt ccatcaaagg ttttctttgg gaggacattaagagcattcc

5041 tgttttcttg tctgcccctg ccagtggcaa tgttccagct ggtagtatccactcctcgcc

5101 catcaggtca gcaatcatga acttctgtgt ttaatttcag gagaaaacaaagggtgggaa

5161 atccttccga aacccctatg tgtgtgcagc agggcagggg aggctggaactggaatcagt

5221 actctcttgg ctgtgcaggt tgcatgctgc aaattcacac acccacacagttgagttgtt

5281 gaggaagatt gtgccgatgg cattatttct gatgccagct tcccttgcatctgcaaagct

5341 tttttcttgt gtctctggca gtcatttgct tgtcaccatt catgtgcactgtccccttca

5401 tcagaggttc tcagagcctg atggtcaagg atatgtcact agagtcttacccccagaccc

5461 attttcaaca gtaagaacgt gaaaccctgg atggggtttg caatctgaagcaactacttt

5521 cttgttagga agagtgctga ctcagaaaat tcaaagaatg ggtaacttccgttggcgaca

5581 tatccccagt gctcataatc aggaattcat ccagttgggg tccatttcaccctcatggca

5641 aaatctggac ataaacattg actagtagct ttaaactggg tataagatttgcaacagata

5701 acatttttgt cttttctttt ttcttttttt tttccacaaa agctaagaatttttcagaca

5761 atttgctctc ttccaaggcc tggatcaatc ccaacttttt cttttaagccatgatccaac

5821 caattgcagt atcctttaaa aatgaaaggg caacaggcta agacattcaagaaagttgat

5881 aagctgtcag aaaatgctca agggtggcct ttctacagtg ccacaaaccaacaacagccc

5941 taaacgtgga gtcctcttcc atcctttcat cagtagggaa taaaaatagggagagagcag

6001 gtcaggggag aagtaacaaa agagaagtaa gaaggattat ttttgatgttcaaaatctgc

6061 tgctgccctt tcaatatttt caaatatcac aatttcagaa agggaaggatccctttattt

6121 cacccactct ccctcccagg aaggtgtttg aagttgctgt ctttacctgaaaaggaggtc

6181 aactcctcaa gtgaaaaaac atcccctatc ttcaactcga agtaaaatggaggtacacac

6241 atttgtacct aattatgtgg gtacaaatat aatttgtatc cacaaactataaaggatgta

6301 aagaatcaaa gaaatccaat ccttaatcaa agtccaattt ttctttaaaacttgagagga

6361 tattttaggg ctcattgcat tgctgtgatt tcactgcccc ccaccaaattatgaaaaatt

6421 actccttttc agaatttaaa tttttctttt gagatgtgga atccaaaggcagcagaatag

6481 tattgttaca gggaagctgg cagtcaaaag acatagacat agctgcagcatgcatggttt

6541 aagcaaatca agacaagcag aaaaccacca ccccaacaag ttcagggttatcagcaatat

6601 agggacacgt atttttatgt gatttttatg agaaccttgc ccctttgacatatgtctgag

6661 tctaggagca ttccggattg caacgggatt gaattcagta ttcaaatcccaccattgggc

6721 agaaaaggca aattgaatgg ggaatggaaa gactgagttg ctcctattgtttatgcccca

6781 ttcctaacta agggctctac agctgttagg tgagatcact acccaccattccaaagtgtt

6841 gttgcgggtg aggaggttca aacgcagctt tggaaacact ttgctgcactctttgaagaa

6901 aggccaacat gctcatttgg ctctagggta aaagagagcc tgtaccctgagctaacattg

6961 gtcacctctc ctcctgaggc cataccacag ccagcagtac agcagcagaacaagtgttta

7021 gttgtttcag cacaggtatc cccagaacac ctggcacctt ttcttttccacagggagaat

7081 gtacattcat gcattttggc aagactgagt cctctgagtt gggtgtctcggaactctcct

7141 attttccttc taaagggtct tatgtaaggt gagcagtaga gtgtgtctcattcctcataa

7201 aaaatcccct tcctgggagg gagtgggtga aatgaaggga tccttccctgactgaaattg

7261 tgctatttga aaaaattgaa agggcagtgg cagattttga acttcaaaatgaatccttcc

7321 tcctcctcct cctcttttgt tacttctccc atgacctgct ctctccctactttaattccc

7381 cattgaagaa aggatagaag aggactctgt gtttagggct actgttgatttgtggcacta

7441 tagaaaggcc acccctaagc attttctgac agctcatccc catctcagtcacagctttta

7501 tttgggtagc tggatttaca gaaataatca aatccctaga ggaaaagacttcaacagaaa

7561 agtacctcct gacacttggg taacctgact tggtcatttc caatttatgcaagatttgta

7621 ttctaaaagt caattagtta tgtcaactgt taaaaactca gaatgagtctttccattctt

7681 cagaatgact cttttctgat tatctgtggg ccatagaagc ccacagatactcagcacagg

7741 atccaagtgc cataccaagt ggtcaactct tttagacgta agtctcagcccagggcttct

7801 ggaatgtacc tcccctagca gagaagctct gtagtagata ctttaccaagcacagggcct

7861 cgctcttgac cccaagacta ctgattctac ttgcagagaa gacaacttttctaatcaatc

7921 tttctcttct atcctgaacc agagtatcag agattgtccc attagggcacgaggatctgt

7981 ggctcaagct cagttaagaa ataagcgtct ttcaaaagaa aggtgcaagagggtggaact

8041 cagcctatat tgtcattatc aaatgcaaga agtctaatcc tagcatgatttattaatatt

8101 agcctttctt ctctccccgt ttatgctttg gtgggtactg gacagaaaccccacaaattt

8161 taagacagtt ttaagagaaa tagtaactgg ttaaatatcc tcactacttcaaattattat

8221 tattattatt gatattactg ttaacttttg tttttttgag acagggtctcactctgatgc

8281 ccaggctgga gtgcagtgat gcgatcacag cccactgtag gctcaaccacccatgctcag

8341 gtgatcctcc cacctcaacc tcccaagtag ctgggatgac aagcgtgtaccaccatgcct

8401 ggctagtatt tttttattat ttttgtagag atgaagtctc cctgtgttacccaggatgat

8461 cttgaactcc tgggcttaag tgatcctccc aacactgcct tctaaagtgctgggtttaca

8521 ggcatgagcc gctgcacttg gcccacttcc tatgattaac aggatattattaatttagaa

8581 actatttagt acatggcaag cactcagtca aatggttatt aacggctgtttttatttcag

8641 gccaccaata tagcttcatc aaggggcaaa tacttatagc ttgggcttcagtgttggatc

8701 agacaccacc ttagaagttt tttgcaatca ttaactcctt aagtaagaagggaactcttt

8761 ttgtaggatt gctttgggga atatgtagcc ccaaggcagg ggctgtactctgagaagctt

8821 gggtagagtt ggagactgtt agaaatggat agacacataa aagcatttagaccaatctgt

8881 tcattttgca gatgaggaaa ttgagtccta gaaaaggcaa gtgacttgttcaagatcaca

8941 cagccaatga tgggagggta ggactcaggg cttgaggatc agtttcagaatgcagtgaaa

9001 ttgttatccc atatttcttt caaatcagta tagggacacg gaacactaacaacataggcg

9061 accaatgggt ctagggagga aaagatgaaa gctgtaggta agtgggagtttggataacaa

9121 tgagatgttt ttctggagtt cctgacaatg cctgaaaaaa aaagtcaggattttaagctt

9181 cagtcaggct caaggtcgag tcctcccact ccagtccctc ctcagacagtaaaacttttc

9241 aagccaagga catacatata ggtgggggca tttgacagtt ggctcatctccccaccctcc

9301 aaattattta tatttctagt ccttcagttt agcactccta tttaccccaggattgtaatt

9361 cattgcctct ttccctggcc atattcctcc atcctttttg tttctcccatctcttttctt

9421 cctccatcac ccccactgct gagcttggct acacttggct agtagtgcaggttgggagaa

9481 cacagagtcc tatcacagac tggaggacta ttatttaatc acaagaatgttgtctttttt

9541 ctcctaaggt agcactctgg ggacggtcat tgctgtcttt attccctcacccccccacca

9601 cccctgcact ggattagaca catgaaatgt gcctatctct gagatgaaaggagcaagaac

9661 tgcttcctcc ccactgacct tttgcctgcc catccttgga gatacctggagttggcaggc

9721 tggaggccta gcagcatttg cagtcagtgc cgctgcctct gggtcagcccaggcttggct

9781 ccttggctgc tactgatgtg ctgccagcta ggaatattaa aaaccattcattgaacgcac

9841 aggatgcttt ataaaatcca acatgctgtt tacagtttat aaattaactgccttgggaag

9901 aggcatttga cttattctcc aaggcatcta gttgactaga tccaattggaatcctttgag

9961 ttcctgggaa ggggctactt aacacttcac actttctaaa ttagacctagagtttcttgc

10021 ttttctgatc ctagtactgt atgaagtttt atctagggtt atctagcaagctttcttcca

10081 cttataaatc tttgatgttt ttgcaatttc tttgatagag gctttatgttctactatctt

10141 cactttattt atgcttcata ccataatttt ttaaaaaatt acaataaatatcaagtaatt

10201 ctggctgata tactgactcc attccaaggt cattatattt tatttgcttaacttggtctt

10261 cttagaaatg atgcaatgaa tactggatac aaattagatg ttcagagagtttatcaatgt

10321 gtctaaaaac catccaggaa aacaacaggc caagactctg cctgcagagtcagtgagcta

10381 gaagagggat cgaggatagg aactatattt ttcccctgac cctatctcttatctgctaga

10441 gcaaaaggag acacacagta ggtgctcaat aaatacatgt taaaaaatatttgttgaaag

10501 aagccacaga agggaatatc agtatacatt agtattgaaa acagcctagggggaaatatg

10561 gatactgaag caccaccctc ctgtgcctgg caagcaaggc aagaataaggccattcttgg

10621 cacataccac ttagcctgtt gctgagataa cttgcgtgaa accagcactttaccctctgc

10681 cagccagaag gtcagcccaa gagtgagctg atctgtgggc acaacaccatctctcaccca

10741 ggaggctggg cccgctgtaa gctctgctat attatttccc tgaggatgacaggtggggaa

10801 atctgggcac cagttgttct tttccactgg tatcatttgg aaggtagctccaaagtcggg

10861 cacgccagcc tacgtgcctc tcctgccggc agaggctcca cattggagctattagaatgt

10921 gggctctgta cgtcggccaa gtccatgtct cagagactgt atccagagcatagcgtggcc

10981 acagggctac tgagttcagc aagagagtca ttctcttgtt caatccattattgcctgggc

11041 caaggttcta agtcttcgta ggcagcattt gattttatga cacgtcttaaaaaattaagg

11101 caaactggaa ttaatttagt tttgagaaaa caacagaagc tgctacaaggcagagataat

11161 tctaggctgc cagaaagtgg tgatctcagt ggtgtacatt ttcttaattcctgattttcc

11221 tctttgtgag gtcttcctcc cactcccata ctttgcacat tctcacctatgcacaccctg

11281 agcaacacaa tgttgacaac ttgacttagc attgctcttt tcttaagctttgttttcatt

11341 tcttcttcaa tacaacagtg ttggttcatt caatttgaac actcaaggcaaaaaaaaaaa

11401 aaaaaatccc aggttatgtt ttcagaatct tacctttttg tttttgttttgagggttctg

11461 tgagttttgt ggcatattta cattgttgct tacattctta tttcagaatttaagataaaa

11521 actgggcaac aactctcacg ttttctgagt gtgttgaaat gaaaaatctgtttcttagaa

11581 ttaatggtaa agcaacattt cctgtcaatc tttcattctt taatattacttctgggttca

11641 gctcaccatc tctaaagaga aagccagatg atcaagttac attgtatgtgacattaacta

11701 tctctttatc tgtgtaaatg tcataatatc tgcttgcaaa gtgttttattcatttttagg

11761 aaaaaatttt aaactgtgct tgcaattcag gatggtgcta ctaggtggcagtaatgtaca

11821 agaactatgt ggtcgccctg gaagagtatt tgactaagag actagcatgccttcccgtaa

11881 ttataagaaa taaaaatata atatttttaa aatactcaaa ctggcacaaacagtaaacat

11941 ccattaactt agttaccata tttaagctga gcttttaaaa gagaaagccttattttttaa

12001 tgaaatttta aataaagtat acattcacaa gctcaaaaat ctaaaaatacgaaaagatat

12061 atagtgaaaa gtctttctct catgcctgtc cctcaactac cacaggtaactaattttgtt

12121 agtttcttgg gtatcctttc agagctttgc tatacaaata tgtgtttttatctctctcca

12181 ttttaactca aatcaataca tagagtttct gcatccttcc atatatagttggttagtata

12241 ttgttgtgtg aacattttag aatataatta accagtcccc tattaatggatatttcatgc

12301 tgtttccaat tttatgctat ttcagccatg tgctcatgtg atttcacatgtaggataatt

12361 cacagaagtg gaattgctgg gtctaaatta tatacatttg catttttaaaaggtattgcc

12421 agattggcct ctacagagtt tggaccaatt tatactgaac tttctccaaaatggacttgt

12481 tttcccacag ccttgccaat agggtgcatg atcagacttc ggaatctttgtaaatctgat

12541 tggttgaaca atgtatttca aagtacttta attttcattc tcttaaatgagacttttatt

12601 ctcttaaatt ctcttctatc tttaagggcc ctttatattt cctttttctgtggagaaagt

12661 ggaaatgcca ataaatacaa cgatgcatac acatgtatag ggttttgttattgatgtagc

12721 ttgtttttgc catcatgctg tacatgatgt tctttaattt gctttgctcatttaaccata

12781 cctcctggcc atggctctga agagaagttg ctggcagtgc agaagaagggccaggactgg

12841 aatgtctgct tctctcttca tccttttgcc attgactcct gggggaaatatctgtagacc

12901 gaagcagtga aatctaatca attctctttc tgacactaat taaggcttcaaagagacaga

12961 taaccacttg ggataattta gtcacagtga aacttgggaa atggtcagtaatatttcatc

13021 ctctgaaagt ggaccccaag aaagttctgg ctctttgagt tgttgtcttggtaattttca

13081 gggtaacgtg tataggaaaa cccagattat gcagatgaaa agaaaacaaacatgctcttc

13141 tgcatccttt gcagatttga aactttgggc acaggtttga tttatttcaatgagatgttg

13201 ctattagcat gaacataaag tggtgcaaag ttgtgctgga atatggtctcgtcaactttg

13261 ggctcactgt ctgcatatgg agatgatagt aactgaatcc atagttatcaagtggtggca

13321 ttttagaaca caaagggaca gcagatgcca tctctgtcaa ctccttccctctacagatga

13381 ggaaacttgg gctagaggag gttgaatgac ttgtgtaagg cttccccagctaattaatgg

13441 cagtgccagg actcaagtcc aggtgggttc cctcattact ggtccttgcccttcctgcaa

13501 tttataggac ttccctgagg cacatgtgct gaggctttgc tattgccagggattctgtgc

13561 tctgaaacag ccctatctca cacacccctt tccacttagg atcccctacctcacacttcc

13621 aagacagcta attgaggcta aatgggtctg atgccattct attagtgcaaaataaattgg

13681 cttatgccaa cttgaactcc taatcttgat tttatcaaca ctttgccctgtttattcaga

13741 ctgttcatga gtaggaagtt aaggaaaatg ttgcctatga acaaaatgatcaaactttta

13801 tctgaaatac ctttgaaagt tttcccgaag ctttaattat catgttccttttgttttgga

13861 tgtaatagca ggccctccca attttcctaa atgtttgaaa atatttttgatactttctgt

13921 cttctgttgt ggttaaaaaa aagaaggcac cagtgttggc tatgcctggggagttagtga

13981 ggtaatctgg agagatctct ggaccccagt cctttgtcca agaggtatggtcaaaagaac

14041 aaagcaaatt tcagaaaaac cggtataata tgatcctatt ttaatggtaagtctgttcca

14101 acaactgctt tctttttcga attacaccat gtgcccaggc tacaaaggctctgcagaaat

14161 gtgactctgt tggcaaatac gcgtgtgata ccttaaccat gctggaggccagttagcata

14221 atgtgtattt cagatgcagt ttgtcatcag tgctgggtgc tatggggcttaaaacaaaaa

14281 caggatgagc ctagagcaca gaagtggaaa attaggtggg tgggtgagtatggacttgga

14341 aatggaaaat gtgcttccct gtgggacatg gcttgtgttc attagtgctgacctgcctcc

14401 tctctagccc tgtaagctga cgctgacacc aaagcttgct gagaaactgaatagaccctc

14461 ccgccccgac caaccaagga caaagatgag accacccaat tcggttacgttgttgccaga

14521 acaacatgtt taatctttaa catgggttca aactattctt ggccctaggaacatggactt

14581 cagcaattaa agtcaacatg tgcttccatt aaaccattgt gtccacctccaaatggttat

14641 aaatatgtag cataagctat gggagttggg gtggaatgga tgacagcctttgctaatgac

14701 gctctagaaa ccaatattct cctctcaaaa taacatggaa aaattctacttaatacctcc

14761 tgggttccat tagtggttct gggtaaataa ttctggggaa agtaatttctgttttcattc

14821 cagctgtgca gcagatactg tgatgatgga ttgcaagtgc aaagagtaagacaaaactcc

14881 agcacataaa ggacaatgac aaccagaaag cttcagcccg atcctgccctttccttgaac

14941 gggactggat cctaggaggt gaagccattt ccaatttttt gtcctctgcctccctctgct

15001 gttcttctag agaagttttt ccttacaaca atgagaaaac atgtactagctgcatccttt

15061 tctatgctct ccctgctggt gataatggga gatacagaca gtaaaacggacagctcattc

15121 ataatggact cggaccctcg acgctgcatg aggcaccact atgtggattctatcagtcac

15181 ccattgtaca agtgtagctc aaaggtaaga ccaaggtctc tgtgaggagagcatttccct

15241 cagaaacagg caagaagcca tatttctttg tcaggggatg gagaactaagatcatagccc

15301 aaacttaagt gatgtggctg gcccacaggg cttgtgggag aatgaggcttttagaatttc

15361 cccccgtgct ttgcactgtt atcagtaaaa gtgcctaatc aatcatgtgcacacccatcc

15421 agtgggacag gtgtcctttg tccctggctg tgatgtttat gagtggtagtgtgcttttcc

15481 aaaaaagaaa aatggagttt acaagtcatc ataactctct agctccatcatcaataaaga

15541 ggaagagaat gcaaagaatg cgattgagca gtggaacata cttcttggagggctctttaa

15601 agagattctt ggtgaaataa ctggctttgt ggtctgagcc tttcttcaggtgctacattt

15661 ctgttcaaat gatttcaaaa gataagatgg caatatgatc atttatcatttttacattgc

15721 ttatccaaat cgttctcatt tggaaaagga tgcatgtttc ttgcagaggcagtccgtgcc

15781 tcagtggtgt gcaagggaat atcatgctta aaaggccacc aagagtggccagctacatgg

15841 accacccaga agggaggcac attgtagggt ggaacatacg agatctcacgactgtcactg

15901 cccctaaaca ggcacaatga atgaaatttg tccacacttg gtaaataataatttgtttag

15961 cccaacctca gagattttta catttagttt tgagatgaaa atcacttaaacattctcgta

16021 tggcaagtaa tttttgaaat taccagtata attaagaatt ttttatagtatcaatcacca

16081 gaattaagac catataagcc aatccctcca ctctccattc aaaaacattatgacttttgt

16141 atgccttgaa aatttccatt aatttctctg attatagctc agtgatgatgattcatttta

16201 gtttaggagg atcagaattc gagttaaatc attttaacca ttatattaataagatctatg

16261 actgtgggaa aaaatagaga ttttccactt aataaaaact ttctggctcttatttgtgct

16321 tgtagaacca aaaaaaaatg gagtaaatag atgaacataa atttttgcagggccacaatt

16381 ccttcttagg aaagggaaac taaaacaaat tgagaaaaaa catgagaagtgcttttacaa

16441 gtgtgattgc tcagaaattg tgggcccatg taaggttgac tgcagcaattattagtttct

16501 ccttccctcc cccttcagaa acagacagca tgaatattta gtgattttattccatggata

16561 atttctttcc gtattgagtt gtcctccata atcgtgattc ttttttaaaaaaaggaatta

16621 aaattatttc aaagaaagtg tcactatgat gatagaaagg aacaaagaaataggagcatc

16681 tataaaaact agaaaacaat ctggaaagac tggacaaaat gatggaggagtactttggca

16741 acaatcacat taatctagcg aaggtcaaag aagagacatc atgaactcaaaccgaagaaa

16801 ttcacatgtg aattctgagc atgagtctta gaaacagact ttagtgtactgttattcacc

16861 tttgtttctt ccagaaagcc atggcaaata acagcgcaaa attgtgatagcaggagaaat

16921 gtttgtaatt tcatgggaac aatctgtttt caaacatccc aaactatcccaaatatagca

16981 atagttttat gtaaatggtg cttgcaatta taaacctttc ttccctggccataaaatatg

17041 cctggcaaaa tctcaactac ccagaccttt tctaggttag atttttctctatgtatccag

17101 gagcaaaact gttttcattt ggaaatgttc tataattctt aactcttacattctcgggct

17161 gatcttttct ctaatgggtc tcacttaatg aaattgtttg cctttagagacttggataaa

17221 acatttagcc tatgtctaga aaagaggcaa caacaatcta ccctagcttctttttacaaa

17281 gaaaagactg ggatagattt ttttgtctct ataaaaatta tcccttgacatcatgttcaa

17341 gggtcattat ttattaaaca tgtgcctact gtttgcctgc caattgttaatgctttctga

17401 ctcacattta tccattatct ggccttgtaa aggcaagaaa gggagaatgtgacccaggct

17461 cagggaaggg agtgtacctg cttgaacacc taatatatgt gtcaggcacctcatattgta

17521 tattataatc attgccaaga aacctgtgat ggcaggcatt attattcccattatcctggt

17581 aaggaaaact gaagcccaaa ataattagat tgcttgatat catatagccagggagtggca

17641 atgtctgcct tacagcattc atcttcccac tacttggatc ttcatattggaggaacacaa

17701 gtagaatgta ggagccatca catagaagtt caggctctgc ttctgatctgctggcagtaa

17761 taatttatac tcagcaatgt ttctagaaaa aataaataat agtgaaagcctttctgggag

17821 ctttcaatga gactgttcat cccagccctg aacttgcagc tggccagtcctaggtccctg

17881 ctgcccatct cctagcaatt ccggaaagga ctgagaggga gtcaggcagaaaagactggc

17941 cacagtggcc caccaaagag gacagtgtgg ccacagatta ggatgtgcctgatagtttta

18001 agtggtggca cctcctgggt ttgggtacaa aagatcctgg gagtagcaggttcatttata

18061 atcttcatgg aagactaagt ttctctaaaa tttggagtaa aggctgtagagcaaacaggc

18121 aaaagaccag ttgatagtgg aaacagactg cctggtggaa tctctatgagaactgaggca

18181 tgccaggctt tgaagtgaga gagacctggt ttccaattcc agctccatggcttgccgaat

18241 gagtgacttt gaggaagttc agtaacttcc ttctttgtgc ctcagtttcttcccatgcaa

18301 aatagagctg tctacctgag ggtatgggta tgggtgttgg tgatttgtaaagcatccagc

18361 ggtgtccagc acataatagc catttaatag aagatattat gatcttgatgataaagttat

18421 aaactaagca ggtgtttaga ctcaattttc tatttcagtc acaactgagatctcaataac

18481 tgctgggatc tcctatagcc ttaaaagatt aggaaaatga accttattgtagttcttgtt

18541 aagcacaggg tggggcagaa gagcaaagta aatgtaagcc actgtgctgggtgctaacag

18601 ggaggataaa agtaaaagag aaacagcccc gatatctgtc taaccttccttcccagatga

18661 gtggaggaag gaggggctgg agggggatga gttttggact tgggccagggaggggatttc

18721 aggaatggag ggtgggaaag caaactggca gggaagacct ggaaagtctcagttgggtga

18781 ggagtggggg atgctggccc caggccaggg catggaacca gggcatgactatctgaaccg

18841 gtaagggcca caggagcagg tggggaactg gaagagcaac aacaaaggataaggaggaag

18901 aggtttggga gacaaaacct aggaaaagag gacctggtat gctaagggctgagtcctaac

18961 agcttcctaa caggaccccc aagccatctt ctactgctac ccaccaagctcatggtgtga

19021 taggagaaat ggagggagtc aggaaaattg tgtttataat acaatagacttcttgagaga

19081 tataatttga tttttttaaa aggaacaaat ttatactgag tgcctaccatgtccaggtgc

19141 tgtggaaggt gctggagact ctaaagtgga aagaaagaaa aaagagacaatttttttgcc

19201 ttcatgatgc ttacaagaaa atggggagag agggaggagg ggtgttctgtgcacaaagat

19261 cagtttgtat ctgtttgatt catgaccgga gtgaagggac cagtttctagttggagtgag

19321 ctgagttccc atccaccctt tcaaagcccc caccatctct ctgctgctttgttccctggt

19381 tgcaattttc ttggtgccct cagcctagca cagatctttt ggaggttgacctgggtccct

19441 gaagatgagc ggagttatga ggctgcccgt ggggaaagaa tgggagaagaagcatgggtg

19501 aatcttgttc ctgaggttat agagggtgtt tcaagaggtg ccatggaaataagggtgcat

19561 agtgttcact gctgcgaaaa aggcaaaata cttttccact ctgtcggagtaaaatcgcaa

19621 aaatgctctt ctagggtggg acaggtgggt ctttattctg atgctaatggtgacatctgg

19681 tcagtcaagg ctcttggaag attcagctct gcataagctt ggggatggtgaagctaatgt

19741 cccaagaagc ccacaagaaa aagttagact tgtatgtcta tggatatggtcaggggtttc

19801 tgaggcaaat caatgtagat aaggaagtct gtgagttggc atatgcttgaggaaaacatg

19861 gtatcaggag gcaggtatta tactggttta ggtcagggct ttggtttcagatagaccttg

19921 gtttgattcc agctctgcat tttaccacct atgtgagttt gggcaagttactggaactct

19981 ctaaagcttg agtttcctta tctgtcctaa tagtgtagat cataacagtactttcttgta

20041 gggttgttgt aaggatgaaa taactcacat tgcaagtgct caataaatgttcttattagc

20101 gaaatgatgg ttatctagtg attcatctag agcacagccc tcaaacttgaatgggtccag

20161 agacctgcta ctcaaagtgt gggcaccagc ccagtaggac tgacatcaactggaatctga

20221 tgggaaatgc agaatctcag gctctaggcc agaactactc aatcagaacttgccttttaa

20281 caagatccta gatgattcac acgcacattc cagtctgaga agctctgatccggaagagat

20341 caggagatgt tcaagtgctg aaacacaagt aaggcatggc agaagctaaaatgtgaagta

20401 ttgagagtaa accaggagag cagatggtta ttccttccat cccttaaggatcttatcttt

20461 caaacttctg ctttaccact tcaacacaca aaacagagat agatttccttctaggagtgt

20521 gtgtgtgtgt gtgtgtgtgt gtgtgtgttg agaacatcaa tggttcaataattgcttcat

20581 agtcttttct tccaggaaag agcatttgaa tttggctaca gagaatagataggtgggatt

20641 ttattaggca gagcaaggtg gaaaggacat atttgggaga cagaagacataagcaaaggc

20701 aagaggcagg agaattcagg gcactttctt ggactcctaa gtagttaagtttgactggag

20761 tagggagtgg gtagtagagt gatgagaata gttgtaagta agactggaaatacatgtgaa

20821 acctgggtca tgaagggcct tgactcctct tcaagatttt ggattttattctgaactact

20881 gaaggcattt attgtacatg tctgtgcatt cttcttgcac aaacagtccagctcccaagg

20941 aagaggggcc cagcccattg gaggtggccc cacgtccttc agtgcctggagttcttgtcc

21001 ttcagagtgg gctgggggtg gagctggaca tcctgaaaac ttttagtgagattgcaatca

21061 gatgagctca tttacaaatg gccctacgct gttgacttgg tcattttatggacagtgcta

21121 atggcccagt cagttaggcc tacgtttggt tcacctgtgt atacatcacttggatattat

21181 gtcccatatc attgttggcc cttctgagtt aagttcgttg gcacagatttactttgtcca

21241 cccagactga aactgcacct ctgaagactc catcacggaa ggtgactctgtgaataactg

21301 cttagtcaac ctaatagatg atctagatga gagattagca aatttaacactactccaagg

21361 tgaggtatca agcagctctt cccacataca gggagatggg gggagaacagactaaggaag

21421 atcttggact ctctctctca ttagagaaat gggggtggga attagggactagcctgtgta

21481 ctactgacct atggcatagt ctctcaaaac ccatttcaga gccaggcacagtggtacatg

21541 cctgtagtcc tggctacaca ggaggctgag gcaggaggat cccttgagctcaggagttta

21601 aggctgtagt gtgctatgat catgcctgtg aataaccact gcactgcagcctggacaaca

21661 tagcaagact ctgtctctaa aaacaaaaca aaacaaacaa acaatcatttctgatagttt

21721 actttgcctg tcaaaatgaa gagcaggtag gatagaatca aaagctttaaaaaaatcaaa

21781 acagcttaca gctgctattt tctctctgcc tctgcgatca ttcagagaaaataaattcac

21841 tggtctagtc caacttattc ttccctaagc cctgctgttt tttttttctagtatttcata

21901 ttgccttggt ggttgctaag tgattgttgg atttagcccc agtatattctcagataacta

21961 tgccaataat ctataattac cagaattcat cttttctccc ttttggaaagatggactggc

22021 tatttttttc ttgtaaacct tgggtgttta attctgccct acaggatgatgtcagagata

22081 atagctggtg agtctttaat aataactgcg aattcctaca atattgtaaggtaaacgtca

22141 aaaggtttca tgcatatata tgtatctttt aatctttcat ttgaacagtttcacttttta

22201 tgatcttgct gttggttctg gaattatagg acaaattttt cttttcttttcttttctttt

22261 tgagacaggg ccttgctctg tcactcatgc tggagtacag tggcttgatcatagcttcct

22321 gcagcctcta attcctgggt tcaagtgatc ctcctgcctc agctgccaaagtagctggga

22381 ctacaggtgc acatcaccac gcctggttaa ctttttattt ttttttttagagacacggtc

22441 atgctatgtt gcccaggctg gtctcaaact cctggggtca agtgatcctcctgcctcaga

22501 ctccaaagtg ttgggattat aggcatgaga caatacacct ggcccaggggatttttttct

22561 ccatcactta acatgaaatt caccaagcaa aacctcttac ataaccatgggaccaataat

22621 ctcagattct ccattcccct ccccaccttg atattaggat tatgcagcttaatgagtcaa

22681 gctgtcccac cctacccacc tattactccc actcccagga taccaggagttttgtatggg

22741 atacataaat gatccttttt tccattccgt taagctgtat gcaaattgtgtgtgtgctta

22801 tgtacatttt tctggggata actttggtag ttttcatcag attcttaaaggtgtctgttt

22861 gctaaagcca gattaagagc tactataaag aacacatagc ctccgttattccagcccaat

22921 ctttggaaat agagattatc agaatgggta catcctaata tttgccgcaaatgactctga

22981 agatgcggat gcaattacat aaatcccagg ctccttcaac atataaacccagaagtgtga

23041 tttcagggcc ccagacatgc cctgtctcta cttcattctc ttgtcccaaattgcagcacc

23101 cagaatattt cttcctaagc attactcagg ctatcctatt ttcttattcagaaactatat

23161 tcctgttctt tagctatttc ctgcacaaat caatttcttt tttttttttttttttttggt

23221 agtcatttta atttacttct tggtttcaat ttggattgac tttctgcattttgctactgg

23281 tagaattgca atgcattggg ccagtggtag accactacct gtcaggagaaatttcttttg

23341 ttctttggtt tttactcgca catcacagtg atgggcgtca ttcagtggttctaaaccctc

23401 agtacactta gaaatcacct aagaagcttt gaaaaccatg aaagcctggtccctatctcc

23461 aaggatttta attcaatcga tctgaatgag gcctgggtgt tgacttaaaaaaaatgcaac

23521 atgcattgag ccactggtct aatctagcag gaattggcaa cgagtgtgagggtctttcaa

23581 aagatgctgt tttacctggc taaggttgtg gcatgcccac agagtaaccacctccttttc

23641 tttccccaga tggtgctcct ggccaggtgc gaggggcact gcagccaggcgtcacgctcc

23701 gagcctttgg tgtcgttcag cactgtcctc aagcaaccct tccgttcctcctgtcactgc

23761 tgccggcccc agacttccaa gctgaaggca ctgcggctgc gatgctcagggggcatgcga

23821 ctcactgcca cctaccggta catcctctcc tgtcactgcg aggaatgcaattcctgaggc

23881 ccgctgctgt gtgtggcttc tggatgggac aactgtagag gcagttcgaccagccaggga

23941 aagactggca agaaaagagt taaggcaaaa aaggatgcaa caattctcccgggactctgc

24001 atattctagt aataaagact ctacatgctt gttgacagag agagatactctgggaacttc

24061 tttgcagttc ccatctcctt tctctggtac aatttctttt ggttcattttcagattcagg

24121 cattttcccc cttggctctc aatgctgttt gggtttccaa caattcagcattagtgggaa

24181 aaagtgggcc ctcatacaca agcgtgtcag gctgtcagtg tttggtgcacgctggggaag

24241 aatttacttt ggaaagtaga aaagcccagc ttttcctggg acatcttctgttattgttga

24301 tgtttttttt taccttgtca ttttggtcta aggttgccat tgctgctaaaggttaccgat

24361 ttcaaagtcc agataccaag catgtggata tgtttagcta cgtttactcacagccagcga

24421 actgacatta aaataactaa caaacagatt cttttatgtg atgctggaactcttgacagc

24481 tataattatt attcagaaat gactttttga aagtaaaagc agcataaagaatttgtcaca

24541 ggaaggctgt ctcagataaa ttatggtaaa attttgtaag ggagcagacttttaaagact

24601 tgcacaaata cggatcctgc actgactctg gaaaaggcat atatgtactagtggcatgga

24661 gaatgcacca tactcatgca tgcaaattag acaaccaagt atgaatctatttgtgggtgt

24721 gctatagctt tagccgtgtc acgggcatca ttctctaata tccacttgtccatgtgaaac

24781 atgttgccaa aatggtggcc tggcttgtct tctgaacgtt tggttcaaatgtgttttggt

24841 cctggaggct caaattttga gttattccca cgttttgaaa taaaaagagtatattcaaaa

小鼠成熟NDP蛋白(SEQ ID NO:23)(NCBI登录号NP_035013.1)

KTDSSFLMDSQRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECSS

小鼠成熟NDP cDNA(SEQ ID NO:24)

aaaacagacagttcatttctgatggactctcaacgctgcatgagacaccattatgtcgattctatcagtcacccactgtacaaatgtagctcaaagatggtgctcctggccagatgtgaggggcactgcagccaggcatcacgctctgagcccttggtgtccttcagcactgtcctcaagcaacctttccgttcctcctgtcactgctgccgaccccagacttccaagctgaaggctctgcgtctgcgctgctcagggggcatgcgacttactgccacttaccggtacatcctctcctgtcactgtgaggaatgcagctcc

恒河猴成熟NDP蛋白(SEQ ID NO:25)(NCBI登录号NP_001253901.1)

MRKHVLAASFSMLSLLVIMGDTDSKTDSSFIMDSDPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECNS

大鼠成熟NDP蛋白(SEQ ID NO:26)(NCBI登录号NP_001102284.1)

KTDSSFLMDSQRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECSS

黑猩猩NDP蛋白(SEQ ID NO:27)(NCBI登录号XP_016799622.1)

KTDSSFVMDSDPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECNS

Trio Rho鸟嘌呤核苷酸交换因子(TRIO)和F-肌动蛋白结合蛋白(TRIOBP)

TRIOBP基因编码“trio Rho鸟嘌呤核苷酸交换因子(TRIO)和F-肌动蛋白结合蛋白”(TRIOBP)(一种沿静纤毛肌动蛋白丝的长度并在内部毛细胞的静纤毛小根中表达的蛋白)。TRIOBP对于内耳中特化毛细胞的静纤毛的稳定性和刚度很重要(参见，例如，Kitajiri等人(2010)Cell 141:786-798；和Zhao等人(2015)Curr.Opin.Neurobiol.34:172-179)。

长度为约10-50μm的静纤毛对于听力和平衡是重要的。静纤毛在听力中起着机械感应作用。通过响应于声音而弯曲，它们形成了机械接收声音刺激的结构。

人TRIOBP基因位于染色体22q13.1上。其包含24个外显子，涵盖约80千碱基(kb)(Hirosawa等人(2001)DNA Res 8:1-9；NCBI登录号NG_012857.1)。迄今为止，存在三个已知的TRIOBP剪接异型体家族：TRIOBP-5、TRIOBP-4和TRIOBP-1(参见，例如，Kitajiri等人(2010)Cell 141:786-798)。TRIOBP-1被普遍表达，而TRIOBP-5和TRIOBP-4主要在内耳和眼中表达。最长的异型体TRIOBP-5基因(NCBI登录号NM_001039141)包含24个外显子，TRIOBP-5异型体的翻译起始位点是在外显子3中发现的。TRIOBP-5蛋白的分子量约为218kDa。TRIOBP-4是由外显子1-6编码的基因，并与TRIOBP-5由相同的启动子表达。TRIOBP-4蛋白的分子量约为107kDa。TRIOBP-1(NCB1登录号NM-007032)由外显子11a-24编码，分子量约为72kDa，并从外显子11a中的起始位点翻译而来(参见，例如，Siepel等人(2001)J.Cell.Sci.114:389-399)。

TRIOBP基因中的各种突变已与非综合征性听力损失相关联(例如，严重的语前聋DFNB28(MIM#609761)(参见，例如，Riazuddin等人(2006)Am J Hum Genet 78:137-143)和年龄相关听力损伤(参见，例如，Hoffmann等人(2016)PLoS Genet 12(10):e1006371))。导致DFNB28的突变主要发现于TRIOBP的外显子6(一种在TRIOBP-4mRNA和TRIOBP-5mRNA中都存在的外显子)中。DFNB28-耳聋可通过产生TRIOBP-4/5缺陷型小鼠来建模，其中将小鼠外显子8(人TRIOBP-4和TRIOBP-5的外显子6的直向同源物)突变/删除(参见，例如，Kitajiri等人(2010)Cell 141:786-798)。无义突变(TRIOBP-5的外显子9中的c.5014G>T(p.Gly1672*))和移码突变(外显子6中的c.2653del(p.Arg885Alafs*120)、c.3460_3461del(p.Leu1154Alafs*29)和c.3232dup(p.Arg1078Profs*6))是在患有先天性和中度听力损伤的荷兰家族中发现的(参见，例如，Wesdorp等人(2017)Hearing Research 347:56-62)。在外显子9中发现的无义突变是仅在TRIOBP-5中存在的第一个疾病相关突变。

已在患有听力损失的受试者中检测到的TRIOBP基因中的其它示例性突变和编码TRIOBP的核酸的测序方法描述于例如Shahin等人(2006)Am J Hum Genet 78:144-152；Diaz-Horta等人(2012)PLoS One 7:e50628；Gu等人(2005)Clin.Genet.87:588-593以及Wesdorp等人(2017)Hearing Research 347:56-62中的表1中。检测基因中的突变的方法是本领域公知的。此类技术的非限制性实例包括：实时聚合酶链式反应(RT-PCR)、PCR、测序、Southern印迹和Northern印迹。

示例性人野生型TRIOBP蛋白为或包括SEQ ID NO:28、SEQ ID NO:30或SEQ ID NO:31、SEQ ID NO:32的序列。编码野生型TRIOBP蛋白的核苷酸序列的非限制性实例为或包括SEQ ID NO:29和SEQ ID NO:33。

在本文所述的任何组合物的一些实施方案中，所述TRIOBP蛋白包含与SEQ ID NO:28具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。

在本文所述的任何组合物的一些实施方案中，所述TRIOBP蛋白包含与SEQ ID NO:30具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。

在本文所述的任何组合物的一些实施方案中，所述TRIOBP蛋白包含与SEQ ID NO:31具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。

在本文所述的任何组合物的一些实施方案中，所述TRIOBP蛋白包含与SEQ ID NO:32具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。

人全长野生型TRIOBP蛋白异型体5(SEQ ID NO:28)

MEEVPGDALCEHFEANILTQNRCQNCFHPEEAHGARYQELRSPSGAEVPYCDLPRCPPAPEDPLSASTSGCQSVVDPGLRPGPKRGPSPSAGLPEEGPTAAPRSRSRELEAVPYLEGLTTSLCGSCNEDPGSDPTSSPDSATPDDTSNSSSVDWDTVERQEEEAPSWDELAVMIPRRPREGPRADSSQRAPSLLTRSPVGGDAAGQKKEDTGGGGRSAGQHWARLRGESGLSLERHRSTLTQASSMTPHSGPRSTTSQASPAQRDTAQAASTREIPRASSPHRITQRDTSRASSTQQEISRASSTQQETSRASSTQEDTPRASSTQEDTPRASSTQWNTPRASSPSRSTQLDNPRTSSTQQDNPQTSFPTCTPQRENPRTPCVQQDDPRASSPNRTTQRENSRTSCAQRDNPKASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRAARDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRTTQQDSPRTSCARRDDPRASSPNRTIQQENPRTSCALRDNPRASSPSRTIQQENPRTSCAQRDDPRASSPNRTTQQENPRTSCARRDNPRASSRNRTIQRDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTSSPNRATRDNPRTSCAQRDNLRASSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRDRTQSFSFQRDNPGTSSSQCCTQKENLRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLRPTQSDGPRTSSPSRSKQSEVPWASIALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQYNLPSRATSSSHNPGHQSTSRTSSPVYPAAYGAPLTSPEPSQPPCAVCIGHRDAPRASSPPRYLQHDPFPFFPEPRAPESEPPHHEPPYIPPAVCIGHRDAPRASSPPRHTQFDPFPFLPDTSDAEHQCQSPQHEPLQLPAPVCIGYRDAPRASSPPRQAPEPSLLFQDLPRASTESLVPSMDSLHECPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSTDSLHGSPVLIPQVCIGHRDAPRASSPPRHPPSDLAFLAPSPSPGSSGGSRGSAPPGETRHNLEREEYTVLADLPPPRRLAQRQPGPQAQCSSGGRTHSPGRAEVERLFGQERRKSEAAGAFQAQDEGRSQQPSQGQSQLLRRQSSPAPSRQVTMLPAKQAELTRRSQAEPPHPWSPEKRPEGDRQLQGSPLPPRTSARTPERELRTQRPLESGQAGPRQPLGVWQSQEEPPGSQGPHRHLERSWSSQEGGLGPGGWWGCGEPSLGAAKAPEGAWGGTSREYKESWGQPEAWEEKPTHELPRELGKRSPLTSPPENWGGPAESSQSWHSGTPTAVGWGAEGACPYPRGSERRPELDWRDLLGLLRAPGEGVWARVPSLDWEGLLELLQARLPRKDPAGHRDDLARALGPELGPPGTNDVPEQESHSQPEGWAEATPVNGHSPALQSQSPVQLPSPACTSTQWPKIKVTRGPATATLAGLEQTGPLGSRSTAKGPSLPELQFQPEEPEESEPSRGQDPLTDQKQADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPTLFNPFLLSLGVLRWRRPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSLAE

人野生型TRIOBP异型体5cDNA(SEQ ID NO:29)

atggaggag gtgcctgggg atgccctgtg tgaacacttt gaggccaaca tacttacccagaaccgctgt caaaactgct tccaccctga ggaggcccat ggagcaagat accaggagct caggagcccttcaggtgctg aggtgcccta ctgcgacctg cctcgatgtc cacctgcccc tgaggaccca ctcagcgcctcaacctccgg ctgccagtct gtggtggacc caggcctcag gccagggccc aagaggggcc catccccctcagcagggctc ccagaagagg gtcccacagc tgcccccagg agcaggagcc gggagcttga ggcagtaccctatctggagg gcctgaccac ttccttgtgt ggcagctgca acgaggaccc cggctctgac cccacctccagccctgactc cgccacccct gatgatacca gcaactcgtc ctctgtggac tgggacactg ttgagaggcaggaggaggag gcccccagct gggacgagct cgcagtgatg atcccgagga ggcctcggga ggggccgagagctgacagct cccaaagggc tccgtctctc ctcaccaggt cccctgtggg aggagatgct gcaggccagaaaaaggagga caccggcggt gggggccgga gcgcaggaca gcactgggca aggctccggg gagaaagcgggttgtccctg gagcggcacc ggtcaacact gacccaggct tcctccatga caccacacag tggacctcgaagcaccacgt ctcaggcttc tcctgcccaa agggacactg ctcaggctgc ctctacacgt gaaatccccagagcctcctc tccccatcga atcacccaaa gggacacctc cagggcctca tccacccaac aggaaatctccagggcctca tccacccaac aggaaacctc cagggcctca tccacccaag aggacacccc tagggcctcatccacccaag aggacacccc cagggcctca tctacacagt ggaacacccc cagagcttcc tctccctcacgaagcaccca actggataac cccagaacct cttctaccca gcaggacaac ccccaaactt cttttcctacttgtactccc cagcgggaaa accccaggac accctgtgtc cagcaggacg atcccagagc ctcctctcccaacagaacca ctcaacgaga gaattccaga acatcctgtg cccagcggga caatcccaaa gcctccagaacctcctctcc caatagagcc acacgagaca accccagaac atcctgcgcc cagcgggaca atcccagagcctcctctccc agtagagcta cacgagacaa ccccacaaca tcctgtgccc agcgggacaa tcccagagcctccagaacct cctctcccaa tagagccaca cgagacaacc ccagaacatc ctgtgcccag cgggacaatcccagagcctc ctctcccagt agagctacac gagacaaccc cacaacatcc tgtgcccagc gggacaatcccagagcctcc agaacctcct ctcccaatag agccacacga gacaacccca gaacatcctg cgcccagcgggacaatccca gagcctcctc tcccaataga gctgcacgag acaaccccac aacatcctgt gcccagcgggacaatcccag agcctccaga acctcctctc ccaatagagc cacacgagac aaccccagaa catcctgtgcccagcgggac aatcccagag cctcctctcc caatagagct acacgagaca accccacaac atcctgtgcccagcgggaca atcccagagc ctccagaacc tcctctccca atagagccac acgagataac cccagaacatcctgtgccca gcgggacaat cccagagcct cctctcccaa cagaaccacc caacaagaca gccccagaacatcctgtgcc cgacgggacg atcccagagc ctcctctcct aacagaacca tccaacaaga gaaccccagaacatcctgtg ccctacggga caatcccaga gcctcctctc ccagcagaac catccaacaa gagaaccccagaacatcctg tgcccaacgg gacgatccca gagcctcctc tcctaacaga accacccaac aagagaaccccagaacatcc tgtgcccgac gggacaatcc cagagcctcc tctcgcaaca gaaccatcca gcgagacaaccccagaacat cctgtgccca gcgggacaat cccagagcct cctctcctaa cagaaccatc caacaagagaacctcagaac atcctgtacc cgacaggaca atcccaggac ctcctctccc aatagagcca cacgagacaaccccagaaca tcctgtgccc agcgggacaa tctcagagcc tcctctccca tcagagccac ccaacaggacaaccccagaa cttgtattca acagaacatc cccagatcat cttctaccca acaagacaac cctaaaacctcttgtaccaa acgagataac ctcagaccca cttgtacaca gcgggaccgc acacagtcct tttcctttcaacgagacaac cctggaacct cctcatctca atgctgcacc caaaaggaga atctgagacc atcatctccccaccgctcca ctcaatggaa caatcccagg aattcatctc cccatcgtac taacaaagac atcccctgggcctcgtttcc cctccggcca actcagagtg atggtccccg aacctcttcc ccatctcgct ccaagcaaagcgaggttccc tgggcatcca tcgccctccg gccaacccaa ggtgacaggc ctcagacatc ctctcccagcaggccagccc agcatgaccc accccagtcc tcctttggcc ccacccagta caacttgcca tcccgggccacctcttcctc ccataaccca ggccaccaga gcacctcccg aacttcctca cctgtgtacc ccgctgcctatggggctccc ctgacctctc ctgagccctc ccagcctcca tgtgctgtgt gcattgggca ccgggatgcccctcgagcct cttcgccccc tcgctatttg cagcacgacc ccttcccctt cttcccagag ccccgcgcccctgagagtga accgccccac cacgagcctc cctatatacc acctgctgtg tgcattggac accgagatgccccccgggcg tcctcgcccc cccgccacac ccaatttgac cccttcccct tcctcccaga cacatcagatgccgagcatc agtgtcagtc cccccaacac gagccccttc agctccctgc acctgtgtgt attgggtaccgagatgcacc ccgggcctcc tccccaccac gccaggcccc agagccttcc ctcttattcc aggacctccccagggccagc acagagagcc ttgtcccttc catggactct ctgcacgagt gcccccacat ccccacccctgtgtgcattg ggcaccggga tgcaccctcc ttctcatccc caccacgcca ggctcctgag ccatccctcttcttccagga tccccctgga actagtatgg agagcctggc cccctccact gactctctgc atggctccccagtgctgatc ccccaagtgt gcatcgggca ccgggatgca ccccgagcct cctccccacc ccgccacccacccagtgacc tagcgttcct ggcaccctca ccttcaccgg gcagctctgg gggctcccgg ggctcagcgcctcccgggga gaccaggcac aacttggagc gggaggagta cactgtgctg gccgacctgc ccccacccaggaggctggcc cagagacagc cagggcccca ggcgcagtgc agcagcgggg gccgcaccca cagccctggccgtgcagagg tggagcgcct cttcgggcaa gagcgcagga agtccgaggc agcgggggcc ttccaggcccaggacgaggg acggtcacag cagcccagcc aaggccagag ccaacttctc cgaagacagt ccagccctgcccccagcagg caggtgacca tgctccctgc caaacaggca gaactgaccc ggcggagcca agcagagccccctcatcctt ggagtcctga gaagagacct gagggagatc ggcagctcca ggggtccccg ctgccccccaggacatcagc caggacccct gagagggagc tgcggacaca gagacctctg gagagtggcc aagcaggcccaagacagcct ctgggggtgt ggcagagtca ggaggaaccg ccagggtccc agggccctca tagacacctagaaaggagct ggagcagcca ggagggaggc ctgggccctg ggggctggtg gggatgtgga gagcccagcctgggggcagc caaagccccg gagggagcat gggggggcac ttccagggag tacaaggaga gctgggggcagccagaggcc tgggaggaga agcccactca tgagctcccc agagaactag gaaagagaag cccactcacgagcccccctg agaactgggg aggccccgca gagtcctcac aatcctggca ctctgggaca cccactgctgtgggctgggg ggcagaggga gcgtgtccat acccgcgtgg ctctgagagg cgacccgagc ttgactggagggatctgctt ggccttctcc gggcaccagg agagggggtc tgggcccgtg tccccagcct ggactgggagggcctcttgg agctcctgca ggccaggctg ccccgcaagg acccagctgg acacagggat gacctggccagggctttagg gccagagctg ggtcccccag gcacaaacga tgtccctgag caggagtcac acagccagccagaaggctgg gccgaggcca ccccagtcaa tggacacagc cccgcactgc agtcccagag cccggtccagctgcccagcc ctgcctgcac ctccacccag tggccaaaga tcaaagtgac aagaggacca gcgaccgcaactctggcagg cctggagcag acgggccccc tggggagcag gagcactgcg aagggcccca gcttgccagagctgcagttc caaccagagg agcctgagga gtcagaacca agcagaggcc aagaccccct gactgaccagaagcaggcag actcggcaga caagaggcca gcagagggca aggctgggag cccgctcaag ggccgactggtgacctcatg gcggatgccc ggggaccggc ccacgctgtt caatccgttc ctgctgtctc tgggggtcctcaggtggcga aggcccgatc tgctcaactt caagaaggga tggatgtcga tcttggacga gcctggagagcctccctccc cctcgctcac caccacctct acttcgcagt ggaagaaaca ttggtttgtg ctgacagattcaagtctcaa atattacaga gactccactg ctgaggaggc agatgagctg gatggtgaga tcgacctgcgttcctgcacg gatgtcactg agtacgcggt gcagcgcaac tatggcttcc agatccacac caaggatgctgtctatacct tgtcggccat gacctcaggc atccggcgga actggatcga ggctctgaga aagaccgtacgtccaacttc agccccagat gtcaccaagc tctcggactc taacaaggag aacgcgctgc acagctacagcacccagaag ggccccctga aggcagggga gcagcgggcg ggctctgagg tcatcagccg gggtggccctcggaaggcgg acgggcagcg tcaggccttg gactacgtgg agctctcgcc gctgacccag gcttccccgcagcgggcccg caccccagcc cgcactcctg accgcctggc caagcaggag gagctggagc gggacctggcccagcgctcc gaggagcggc gcaagtggtt tgaggccaca gacagcagga ccccagaggt gcctgctggtgaggggccgc gccggggcct gggtgccccc ctgactgagg accagcaaaa ccggcttagt gaggagatcgagaagaagtg gcaggagctg gagaagctgc ccctgcggga gaataagcgg gtgcccctca ctgccctgctcaaccaaagc cgcggagagc gccgagggcc cccaagtgac ggccacgagg cactggagaa ggaggttcaggctcttcggg cccagctgga ggcgtggcgt ctccaagggg aggctcctca gagtgcactg agatcccaggaggatggcca catccccccg ggctacatct cacaggaggc atgtgagcgc agcctggcag agatggagtcctcgcaccag caggtgatgg aggagctgca gcggcaccac gagcgggagc tgcagcgcct gcagcaggagaaggagtggc tcctggctga ggagacggca gccacggcct cagccattga agccatgaag aaggcctaccaggaagagct gagccgagag ctgagcaaaa cacggagtct ccagcagggc ccggatggcc tccggaagcagcaccagtca gatgtggagg cactgaagcg agagctgcag gtgctatcgg agcagtactc gcagaagtgcctggagattg gggcactcat gcggcaggct gaggagcgcg agcacacgct gcgccgctgc cagcaggagggccaggagct gctgcgccac aaccaggagc tgcatggccg cctgtcagag gagatagacc agctgcgcggcttcattgcc tcgcagggca tgggcaatgg ctgcgggcgc agcaacgagc ggagttcctg cgagctagaggtgctgcttc gcgtaaaaga aaacgaactc cagtacctaa agaaggaggt gcagtgcctc cgggacgagctccagatgat gcagaaggac aagcgcttca cctcgggaaa gtaccaggac gtctatgtgg agctgagccacatcaagaca cggtctgagc gggagatcga gcagctgaag gagcacctgc gtcttgccat ggccgccctccaggagaagg agtcgatgcg caacagcctg gctgagtag

人全长野生型TRIOBP蛋白异型体1(SEQ ID NO:30)

MTPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSLAE

人全长野生型TRIOBP蛋白异型体4(SEQ ID NO:31)

MIPRRPREGPRADSSQRAPSLLTRSPVGGDAAGQKKEDTGGGGRSAGQHWARLRGESGLSLERHRSTLTQASSMTPHSGPRSTTSQASPAQRDTAQAASTREIPRASSPHRITQRDTSRASSTQQEISRASSTQQETSRASSTQEDTPRASSTQEDTPRASSTQWNTPRASSPSRSTQLDNPRTSSTQQDNPQTSFPTCTPQRENPRTPCVQQDDPRASSPNRTTQRENSRTSCAQRDNPKASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRAARDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRTTQQDSPRTSCARRDDPRASSPNRTIQQENPRTSCALRDNPRASSPSRTIQQENPRTSCAQRDDPRASSPNRTTQQENPRTSCARRDNPRASSRNRTIQRDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTSSPNRATRDNPRTSCAQRDNLRASSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRDRTQSFSFQRDNPGTSSSQCCTQKENLRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLRPTQSDGPRTSSPSRSKQSEVPWASIALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQYNLPSRATSSSHNPGHQSTSRTSSPVYPAAYGAPLTSPEPSQPPCAVCIGHRDAPRASSPPRYLQHDPFPFFPEPRAPESEPPHHEPPYIPPAVCIGHRDAPRASSPPRHTQFDPFPFLPDTSDAEHQCQSPQHEPLQLPAPVCIGYRDAPRASSPPRQAPEPSLLFQDLPRASTESLVPSMDSLHECPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSTDSLHGSPVLIPQVCIGHRDAPRASSPPRHPPSDLAFLAPSPSPGSSGGSRGSAPPGETRHNLEREEYTVLADLPPPRRLAQRQPGPQAQCSSGGRTHSPGRAEVERLFGQERR

人全长野生型TRIOBP蛋白异型体6(SEQ ID NO:32)

MEEVPGDALCEHFEANILTQNRCQNCFHPEEAHGARYQELRSPSGAEVPYCDLPRCPPAPEDPLSASTSGCQSVVDPGLRPGPKRGPSPSAGLPEEGPTAAPRSRSRELEAVPYLEGLTTSLCGSCNEDPGSDPTSSPDSATPDDTSNSSSVDWDTVERQEEEAPSWDELAVMIPRRPREGPRADSSQRAPSLLTRSPVGGDAAGQKKEDTGGGGRSAGQHWARLRGESGLSLERHRSTLTQASSMTPHSGPRSTTSQASPAQRDTAQAASTREIPRASSPHRITQRDTSRASSTQQEISRASSTQQETSRASSTQEDTPRASSTQEDTPRASSTQWNTPRASSPSRSTQLDNPRTSSTQQDNPQTSFPTCTPQRENPRTPCVQQDDPRASSPNRTTQRENSRTSCAQRDNPKASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRAARDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRTTQQDSPRTSCARRDDPRASSPNRTIQQENPRTSCALRDNPRASSPSRTIQQENPRTSCAQRDDPRASSPNRTTQQENPRTSCARRDNPRASSRNRTIQRDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTSSPNRATRDNPRTSCAQRDNLRASSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRDRTQSFSFQRDNPGTSSSQCCTQKENLRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLRPTQSDGPRTSSPSRSKQSEVPWASIALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQYNLPSRATSSSHNPGHQSTSRTSSPVYPAAYGAPLTSPEPSQPPCAVCIGHRDAPRASSPPRYLQHDPFPFFPEPRAPESEPPHHEPPYIPPAVCIGHRDAPRASSPPRHTQFDPFPFLPDTSDAEHQCQSPQHEPLQLPAPVCIGYRDAPRASSPPRQAPEPSLLFQDLPRASTESLVPSMDSLHECPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSTDSLHGSPVLIPQVCIGHRDAPRASSPPRHPPSDLAFLAPSPSPGSSGGSRGSAPPGETRHNLEREEYTVLADLPPPRRLAQRQPGPQAQCSSGGRTHSPGRAEVERLFGQERRKSEAAGAFQAQDEGRSQQPSQGQSQLLRRQSSPAPSRQVTMLPAKQAELTRRSQAEPPHPWSPEKRPEGDRQLQGSPLPPRTSARTPERELRTQRPLESGQAGPRQPLGVWQSQEEPPGSQGPHRHLERSWSSQEGGLGPGGWWGCGEPSLGAAKAPEGAWGGTSREYKESWGQPEAWEEKPTHELPRELGKRSPLTSPPENWGGPAESSQSWHSGTPTAVGWGAEGACPYPRGSERRPELDWRDLLGLLRAPGEGVWARVPSLDWEGLLELLQARLPRKDPAGHRDDLARALGPELGPPGTNDVPEQESHSQPEGWAEATPVNGHSPALQSQSPVQLPSPACTSTQWPKIKVTRGPATATLAGLEQTGPLGSRSTAKGPSLPELQFQPEEPEESEPSRGQDPLTDQKQADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPTLFNPFLLSLGVLRWRRPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSLAE

人野生型TRIOBP基因DNA序列的非限制性实例是SEQ ID NO:33。SEQ ID NO:33中的外显子是：核苷酸位置1-102(外显子1)、核苷酸位置601-709(外显子2)、核苷酸位置4319-4492(外显子3)、核苷酸位置13440-13579(外显子4)、核苷酸位置16223-16424(外显子5)、核苷酸位置18776-18947(外显子6)、核苷酸位置26198-29516(外显子7)、核苷酸位置36311-36425(外显子8)、核苷酸位置37412-38455(外显子9)、核苷酸位置41655-41732(外显子10)、核苷酸位置43908-44045(外显子11)、核苷酸位置54785-54841(外显子12)、核苷酸位置57890-57997(外显子13)、核苷酸位置58114-58203(外显子14)、核苷酸位置58563-58672(外显子15)、核苷酸位置60626-61151(外显子16)、核苷酸位置62167-62277(外显子17)、核苷酸位置68683-68830(外显子18)、核苷酸位置71087-71189(外显子19)、核苷酸位置72041-72200(外显子20)、核苷酸位置72275-72388(外显子21)、核苷酸位置74663-74749(外显子22)、核苷酸位置75614-75777(外显子23)和核苷酸位置76796-79569(外显子24)。内含子位于SEQ ID NO:33中的这些外显子的每一对之间，即处于核苷酸位置103-600(内含子1)、核苷酸位置710-4318(内含子2)、核苷酸位置4493-13439(内含子3)、核苷酸位置13580-16222(内含子4)、核苷酸位置16425-18775(内含子5)、核苷酸位置18948-26197(内含子6)、核苷酸位置29517-36310(内含子7)、核苷酸位置36426-37411(内含子8)、核苷酸位置38456-41654(内含子9)、核苷酸位置41733-43907(内含子10)、核苷酸位置44046-54784(内含子11)、核苷酸位置54842-57889(内含子12)、核苷酸位置57998-58113(内含子13)、核苷酸位置58204-58562(内含子14)、核苷酸位置58673-60625(内含子15)、核苷酸位置61152-62166(内含子16)、核苷酸位置62278-6862(内含子17)、核苷酸位置68831-71086(内含子18)、核苷酸位置71190-72040(内含子19)、核苷酸位置72201-72274(内含子20)、核苷酸位置72389-74662(内含子21)、核苷酸位置74750-75613(内含子22)和核苷酸位置75778-76795(内含子23)。

人野生型TRIOBP基因组序列(SEQ ID NO:33)(NCBI登录号NG_012857.1)

1 cttccacctc ccgagcatcg ctctgattca ttgttaaaat aaagaggcca tgaccctggc

61 actcccaccc cggcagcccc tgtgcgtgga aacccagcca aggttagcac tgggcctcag

121 aaaagaggag ctggtagggg gaggcctaca ggaggggtag gggtcgaggg atccggggag

181 gaactggctg aatgcctgga tggagagggt cccgggtcca ttctctgggt ggggcatgtg

241 tagctgctta aggttttgat tattatatcc acatctcaag tgcattttag agaaggattc

301 tgcctattgg ttgtgggtag gggaggaaac gggagcagcg aggggcacgt ggagtagagc

361 cccctaccca cccccaggaa aatgagcggc gttctcctgc taggcgacgc tcctttatgt

421 ggccagacca ggagagaaac gcccaggacg ggcggggccg atgcgcccct cttccaccac

481 caggagtcgg gaggacgacc gcccggggag gatcagagac cctggggcca cggaaggacc

541 agtgggtagc cctctcccca ccgtgccttg ctgtcgcccc caccgcattc ccttctccag

601 gtctgatgat ggaggagcct tggccctggc tgtcccaggg gaggaggtga aattcctcag

661 ctctccacca agattggcca caaaagcctg atcccctgga acacagcagg tgaggatgga

721 tgtgggcagg tgacctgggg gcaccaaaag ctgcaggtgt tttgggatgt tgggttcctc

781 ccacccccca ccctccccct ggggctctgt gtgagtgggg aggccatctt taagtgattc

841 tcctgaccca gctccactcc agggcatgga tgttggtggc cttaggggca cccagaaagg

901 agaacccttg cacaagtaag ataccagggc ggccgggcgc ggtggctcaa gcctgtaatc

961 ccagcacttt gggaggtcga ggtgggtgga tcacaaggtc aggagttcga gaccagcctg

1021 gcccatatgg tgaaacctcg tctctaccaa aaatacaaaa aaattatccgggcatggtgg

1081 cacatgcctg taatcccagc tatttgggag gctgcggcag gagaattgcttgaatccggg

1141 aggcagaggt tgcagtgagc cgagatcgcg ccactgcact ccagcctgggtgatagaccg

1201 agattctgtc tcaaaaaaaa aaaaaaaaaa agaaagaaag acaccagggtttcagaaggg

1261 tatgatgctt cacacctgta atcccagcac tttgagggaa ggaggaggattacttgaggt

1321 caggagttca ggagttcaaa accagcctgg gtaacactgc aagagccttttttttttttt

1381 tttttttttt tgagacacac tgttgcccag gctggagtgc agcggggcgatcttagctcc

1441 actgcaacct ccacctcctg ggttcaagca attctcttgc cccagcctcttgagtagctg

1501 ggattacagg catgcgcacc acgcccagct aatttttata gttttagtagagacagggtt

1561 tcatcatgtt gggcaggctg gtcttgaatt cctggcctca agtgatctgcctgcctcagc

1621 ctcccaaagt gctgggatta taggcgtgag ccaccgcacc tggccaagagcccattttta

1681 caaaataaaa aagaaaaaaa ttagctgggc gtggtggcgt acacctgtagtcccagttac

1741 tcagtcccag agactgaggc aggagaatca tttgagcccg ggagtttgaggttgcaagga

1801 gctatgatcg agccactgca ctccagcctg ggtgacagag caagaccctgcccccacctc

1861 cccaaaaaag acattagggg ccggatgcag tggctcacac ctgtaatcccagcattttgg

1921 gaggccgaag ggggcggatc acctgaggtc aggagttcac ctggccaacatggcgaaacc

1981 ccgttgctac taaaaataca aaaattagcc aggcatgacg gtgcatgcctgtgatcccag

2041 atactactgg ggaggctgag gtagaattgc ttgaacccag gaggcggaggttgcagtgag

2101 ccgagtgagc caagatcaca tcacggcact ccagcctagg tgacagagagagacttcgtc

2161 tcaaaaaaac aaaacaaaac aaaacgaaaa cacattagga tttctttttggctaagttct

2221 gccacaaact tgctgtgtga ctttaggctg ttcacgtttg tcaaagacgtcgtcctcaac

2281 tctgaaaata cctggccagc tttttgcctc cctcgctgtg cttcccaagggacctgtgcg

2341 agttggcagt atgatccagt gctcctcact tccacctccg agagagcagggacacacaca

2401 gccctggatt tgaatcagcc actgcgacct tcagtgaccg aaggaacctctctgagcctt

2461 agttgcctga tctaaaattg gcattaattt gatctacaat gcagctataagacaaggaca

2521 ctcaaacttt ggggcgcact agaatcacct ggggaatcac tttttttttttaagacagag

2581 tctcactctt atcacccagg ctggagtaca gtggtgcaat cttggctcactgcaacctcc

2641 gcctcctggg ttcaagtgat tctcctgcct cagcctcccg agtaactgggactacaggtg

2701 cataccacca tgcctggcta attttgtatt tttagtagag acagggtttggcaatattgg

2761 ccaggctggt ctcgaactcc tgacctcagg tgatctgccc gcctcggcctcccaaagtgc

2821 tgggattata ggcgtgagcc actgcgcctg gccaggaatc gcttctttattttcattttc

2881 atttatttat ttatttattt atttattttg agatggagtc tcgctctgttgctcagtctg

2941 gagtgaagtg gcgtgctctc cgctcactgc tacctctgcc tcccaggttcaagcgattct

3001 cgtgcctcag cctcccaagt agctgggact acaggtgcgt gctaccacgcccagctaatt

3061 tttgtattta gtagaggcgg ggtttcacca tgttggccag gctggtcttgaactcctggc

3121 ctcaagtgat ctgcctgcct cagcctccca aagtgctggg attacaggcgtgagccaccg

3181 ccctcggctg gaatcacttc tttaacatgc acagccccag acctcagtctcttggagatt

3241 ctaactgtgt gaattgggag agagaaaggg gaatctagat tttttttttttttttttgag

3301 atgtggtctt gctatgttgc ctaggctgga gtgctgtaac tattcacaggtgcagttata

3361 gcacactacc acctcaaact cctgggctca agagatcctc ccacctctgcctcccgagta

3421 gcttggactg caggtgcaca ccatcttacc cagctgaaat ctgctttttttttttctcag

3481 tgcagtggca cagtcatggc tcactgcagc ctcgacctcc cagactcaggtgatcctccc

3541 aacttcagcc tcctgagtag cagggaccac aggcctgcac caccttgcccagctaatttt

3601 tgtatttttt gtagagacgg agtttcgcca gttgcccagg atggtcttgaactcttgggc

3661 tcaaatgatc cgccgcccgc aatgggccca gctggaatct gcatttttttgttttttgtt

3721 ttgagatgaa gtctcactct gtcgcccagg ctggagtgca atggcgcaatcttggctcac

3781 tgcaacctcc gcctcctggg ttcaagccat tctcctgcct caggctcccaagtagctggg

3841 attacaggca cgtgccatca cacttggctg atttttgtat ttttagtagagacagggttt

3901 taccatattg gccaggctgg tctcgaactc ctgacctcaa gtgatcggcccacctcggcc

3961 tcccaaagtg ctgggattac aggcatcagc cactgtgcct ggcctggtatctgcattttt

4021 atgaacagcc caggagggtg taatgcagag tccttggcgt gcactttcagcaacactgca

4081 gtaaggacta gaaatcgcac atcaaatgct ggcagagtgc ctggtgcttagtaggtgctt

4141 agtgagtgtt tgttgagtga ataaatgaac aggaatggat ggagaacaggaacccaaagg

4201 aatggatgag taaccttatt tccttggtcc ttgtctggaa actggggcaactggggctgg

4261 ggttcaggtg agtggccagc cagtcatctg gtctttgcct ccccctcatttttgccaggc

4321 ctcacataga cggtcagcca ttggatcata ggaactgccc tggcctgactcacccaatat

4381 ggaggaggtg cctggggatg ccctgtgtga acactttgag gccaacatacttacccagaa

4441 ccgctgtcaa aactgcttcc accctgagga ggcccatgga gcaagataccaggtgggcca

4501 gttttccacg tggttggggt ggtttgtgat gggggcatgg gtgaaggactgggcctgtgg

4561 tgtccgctaa ctcgcagttg aacccagatg ctggacttcc tcctgtcgagagcctcggtt

4621 ttcccacatt gcagggaagt ggttgaacca tgtgaatgtt tcacaatcttcagtcacttt

4681 cctcctgctt atatgatacg attgttacca tagccttatc taatctgttacttactttgt

4741 tattctttaa atcaacatct ttttcccctt ctattgaaac aaaacttcacatcatcaaca

4801 caagtagaaa actagaatta cttcctgtta agaagaagag gttaagaagaaaggtagagg

4861 ctgggcacgg tggctcacgc ctgtaatccc agcactttgg gaggccgaggtgggtggatc

4921 acccgaggtc gggagtttga aaccagcctg gccaacatgg tgaaaattagctgggcatgg

4981 tggtgcatgc ctgtaatccc agctacttgg gaggctgagg caggagaatcacttgaacct

5041 gggaggcgga gattgtggtg agccgagatc gcgccattgc actccagcctgggcaacaga

5101 atgaaactgt ctcaaaaaac aaaacaaaac aaaacaaaaa agagaagaaaggtagaaaaa

5161 gaaaaaacaa aacagaaatg tcgttacacc ctaacttgag agtgttttctttttcttttt

5221 cttttttttg agacagagtc tcactctgtc gcctgggcta gagtgcaatggcaatggtgt

5281 gatctcagct cactgcaatc tctgcctcct aggttcaagc gatcctcccgcctcagcctc

5341 ccaagtattg ggattacagg tgcctgccac catgcccagc taatttttgtatttttagta

5401 gaaacggggt ttcgccatat tggccaggct ggtcttaaac tcctgacctcaggtgatcca

5461 cccgcctcag cctcccaaag tgttgggatt acaggcgtga gccaccgcgcctggcctcga

5521 gagtgttttc tatggaaggc tctgagcttg catcctgctg tctctttgtcaaaaagggag

5581 attagcagat gttagagaga tgttaagaat acaccagcat catctagagattttctttct

5641 ctctctcttt tttttttttt tttttttttt tggagatagg gtcttgctctgtagcacagg

5701 ctggagtgca gtggtccaac ctatagtaca tggctcactg tagcctcgacctcccaggct

5761 caaatgatct tcccaccttg gcctcctgag tagcagggac tacaggcacatgccaccatg

5821 gccagctaat tttcttgtaa agatgggatc tcactatgtt gccagggctggtctcaaatt

5881 cctgggctca ggtgatcctc ccacctcaac ctctgtaact gcagggattacaggtgtgag

5941 acactgcacc tggtctcaag attttcttct tcaagttatt gaaggagtgaagaagaatcc

6001 ttttttttct ttcttttttt ttcatttgag acggagtctc tctctgtcgccaggctagag

6061 ttcagtggct caatctcagc tcactgcaac ctccgtctcc tgggttcaagcaattctcct

6121 gcctcagcct cctgagtacc tgggattaca ggtgcccacc accatgcccagctaattttt

6181 gtatctttag tagagacagg gtttcaccat gttggtcagt ctggtctcgaactcctgacc

6241 ttgtgatctg tctgcctcgg cttcccaaag tgctgggatt acaggtgtgagccaccgcgc

6301 ctggccgaga ttttcttctt caagttattg aaggagtgaa gaagagtccttttctgactt

6361 tgtgattgat gtagtctgct gccaagcccc catgcatgta aacacagagcacctgataca

6421 cacgcaatga gaaacctggg actcacgaac ctccgagggc ccttccaaccttgaccacca

6481 tggcttcgtc attcccattg gggtctgaag gtcctctttt tttttttttttttttgagac

6541 agagtctcgt tctgttgccc aggctggagt acagtggtgc gatctgggctcactgcaagc

6601 tcggcctccc aggtttatgc cattctcctg cctcagcctc atgagtagctgggacaacag

6661 gcacccggca ccacgcccag ctaatttttt gtctttttag tagagacagggtttcaccat

6721 gttagccagg atggcctcga tcttcctgac ctcgttattc gcccacctcgacctcccaaa

6781 gtgctgggat tacaggcatg agccaccgcg cccagcttct accagtcttgatacctccaa

6841 taatagctct cttgtgctca cctgcaagtt caggttcagg gaacagatgcctgggagtcc

6901 atctttcatg caaatgactt tcttccagtg gttgggaaga tggcaagaatggaacaggag

6961 agccgtggat tcaggctcgt ctgagttcta gtctcaatcc caccatttcccacccgagac

7021 cgtgggtcag ctcacaaatt catacgtact gaataggtgc ttaaaatgtgccaggcatta

7081 tgctagatga tggggaaatc atgataaatc agaaaggcac agccaggcacagtgactcac

7141 tcctgtaatc ccagcacttt gggaggccaa ggtgggtgga tcacttggagtttgagacca

7201 tcctggcaac atggcaaaac cccatctcta caaaaaattt aaaaaattagctgggcgtag

7261 tgggatgcgg ctatagtctc agttactcag gaggctgagg tgggagaatcacctgagact

7321 gggaggcggg ggcttcagtg agccgtgatc gcattactgt atttcagcctgggtgacaga

7381 gttggaccct gactcagaac agaacagaac agaacagaac agaacagaacagaacagaac

7441 agaacagaac agtacagaaa acagggagaa ggaggggaag ggggaggggaagggggaggg

7501 ggagagagag gaggagagga ggagagaggg acacatccct ggcttgtcttcatggggctt

7561 atattctagc aagagaaatg cacatgatta tttaatcttg gttgtgataaatgtataaag

7621 gaacagtaag tggcatgaag gtaaaggata gggcattagg gaaagtttctccaaaaaaaa

7681 aaaaatgaca tttcagctgc ttagtaaagg ctgtgcaggc attagcattagtgaaattgc

7741 aggaagagga gaggaaggaa ggagaatgtg caaaggccag cctggcacggcagctcacgc

7801 ctgtaatccc agcactttgg gaggaagtgc ttggattgag gcaccgaagcaggaagatca

7861 cttgaactca ggagtttgag accagcctgg gcagcacagt gagaccccatttctaccaaa

7921 aaaaaaaaaa aaaaaattag ccaggcagga tggtgcacac ctgtagtcccagctagtcag

7981 aaggctgatg tgggaggatt actggatccc aggagttcaa ggttgcagtgagccatgagc

8041 atgccaatgc actccagcct gggcaacaga atgagacctt gtctcaaaaacaaaacaaac

8101 aaacaggtca ggtgcagtgg ttcatgcctg taatctcagc actttacgaggccgagacgg

8161 gtggatcacc tgaggtcagg agttcaagac caccctggcc aacatggtgaaaccccatct

8221 ctattaaaaa tacacaaatt agctacatgt ggtggtgggt gcctgtaatcccaggtactt

8281 aggaggctga ggcaggagaa tctcttgaac ccaggaggca gaggttgcagtgagccaaga

8341 ttgcaccact gtactccagc ctgggcaaca gagcgagaat cctctcaaaacaaaacaaac

8401 aaacaaagaa tatgcaaagg ccctgaggca gaaaggaggc tgcacatcgggctggagagg

8461 acaggcaaga ggggggcaca gaggagctat aggacaagga tggagaatggggggaggcct

8521 ggtctcactg gccttgtgcg gctttgtgga catgttgagg acttaggattctgaggtttt

8581 tttctgtttt gtttttgttt ttttttgaga tggagtctcg ctctgtcgcacaggctggag

8641 tgcagaggcg tgatctcggc tcactgcaac ctctgcctcc caggttcaagcgattctcct

8701 gcctcagcct cccaggtagc tgagactaca ggcatgtact accaaacccagttaattttt

8761 gtatttttag tagagatggg gtttcaccat gccgctcagg ctggtcttgaactcctggcc

8821 tcaagcaatc tgccctcctt ggcctcccaa agtgctgaga ttacaagtgtgagccacctc

8881 gcccggccaa gccacggaag atttcaaata agggagtgac gtgctctgatttgcattttt

8941 cacagtcact ctgattgctg ggcagagaga atggagggca gggtggtgagagtgaatcag

9001 gtgacccgcc aggaaaaggt gcacgtactc atcggtgcca gagatgattggggctttgag

9061 atggaggcaa atggacacat ttccgaacta attgagcagg cacgtctacaggatttgggg

9121 gtgagggagg ggagaaaccc atggctgact cctgtaattt cttcaggcagggtacttggg

9181 ttgggaggtc tgtttggagt tgtctggggc atggtgtggg gtgtcggcaggatacagtgg

9241 agatgagggg gaagttagtg aattggtggg gctggagctc agagccagaccatcacagga

9301 gatggaggcc tgcgagtctt caggatctgt cactgaccaa agtcttgctcacggatgagc

9361 ctatcatctg tggaagaaag tgtggaatga gatgagaaca ggcctgggtggaggccaggg

9421 aatcagcaga gacagccaag aaggccagag gctaggaggc aaaccccacagtgtgcccct

9481 cctccccagg agccaagacc agagatggtt tcaagagagg gggccaggcacaatggctcc

9541 cgcctgtgat cacagcactt taggaggctg aggctaaagg atggcttgaaaccaggagtt

9601 taagaccagc ctagttaaca aagtgagatc ccatctctac aaaacaaaaaatgaactggg

9661 tgtagtggtg catgcctgca gtcccagcta cttgggaggc tgaggcaggaggattgtttg

9721 agcccaggag attgaggctg cagtgcactg tgatcatgcc actgccacagcaagactatc

9781 ttaaaaaaaa aaaaaaaaga tcagagaggg gcacgacatc aaatcctccactttcttgag

9841 cttccagttg ctctgatgat gatcaaggct gtgaaactct cctttggcaaatgcatgagg

9901 ggtgactgtt gtgtctccga gccaggccct gggacccaac tctgggcaggtagcagctcc

9961 ctgtgtatac cagatgtgat agtaaaaaac tgacactggg ccgggcgcggtggctcacgc

10021 ctgtaatccc agcactttgg gaggccgagg cgggtggatc acttgaggtcaggagtttga

10081 gaccagcctg actagcatgg tgaaatcctg actctactaa aaatacaaaaatacaaaaat

10141 taacagggtg tggtggcgga tgcctgtaat cccagctact cgggaggctgaggcaggaga

10201 atttcttgaa tccgggaggc ggaggttgca gtgagccgag atctggccaccgcactccag

10261 cctgggcgac aagagcgaaa aactccatct caaaaaaaac aaaaaaacctcctgggcccc

10321 agaagatggc aactgcctct tccagcctct tccacctgcc tgcctgtgcactcctctgcc

10381 actctggacc tattccatgg tgccacgtgg tcaggcattg aaggaatgggtgggtttttt

10441 ttccatcacc ctcagatgct gctgctgggg ttggggcggg tcttccctggctgactctgt

10501 ctgcctcacc cactctctcc ccatctctct gtcaccacag gtctccagggaccaaattta

10561 gcccattttt cctccaagga ttctggaccc ttggccatat ttgcctctagctttaggtca

10621 acagatttct aacatggagt caaaaaatct gtatgtttaa aaaaaaaaaattggctggga

10681 gtggtggctc acgtctgtaa tcccagcact ttgggaggcc gaggcaggtggatcacctga

10741 ggtcaggagt tcgagaccac cctggccaac atggtgaaac cccgtctctactaaaaatac

10801 aaaaattagc tgggtatggt ggcggacccc tgtagtccca gctactcaggaggctgaggc

10861 aggacaattg cttgaacccg ggaggcagag gttgcagtga gctgagatcgcgccattgca

10921 ctccagcctg ggtgacagag tgagactctg tctcaaaaaa aagaaaaaaaaaaaaaaggc

10981 cgggcgtggt ggctcacggc tgtaatccca gcactttggg aggccgaggcgggcggatca

11041 cgagatcagg agatcgagac catcctggct aacacggtga aaccctgtctctactaaaaa

11101 tacaaaaaat tagctgggca tggtggcggg cgtccatagt cccagctactcgggaggctg

11161 aggcaggaga atggcatgaa cccgggaggc ggagcttgca gtgagccaagatcacgccac

11221 tgcactctag cctgagcgac agagtgagac tccgtctcac aaaaaaaaaaaaaaaaaaaa

11281 attgaggcca ggcacagtgg ctcatgcctg tgatcccagc actttggccgaggcaggcag

11341 atcacctgcc atcaggagtt cgagaccagt ctcgccaaca tggcaaacccctgtctctac

11401 taaaaataga aaaattagcc gggcatggtg tcgggcacct gtaatcacagctactggggt

11461 ggctgaggca gaagaattgc ttgaacccag gaggcgaagg ttgcagtgagccgagactgc

11521 accattgcac tctaacctgg gctataagag cgagactctg tctcaaaaaaaaagcccttt

11581 acaaatatta actcgtttaa ttctcagaac acccctagga ggtgggtcctgctatcctgc

11641 cggttttgta gatgaggtaa ctgaggcaca gagaggataa gtcacgtggcccaggtcttg

11701 gtcgcttctc agcctccatt tccgagagga gaaaacaatg ctccgaaaggggaagtcatc

11761 ggcctgaggt caccagccgg gaaccggagg agccaggatg gggcccgaggtccatctgag

11821 gccagagcca gtgctgaccc gccagacagg aaatcagagc tggggactgaccgtggggcc

11881 cactcaagtg ggtggtgtgg ggtggtgacg ggggctgggg tgaaagccaggatgaggtgt

11941 cacattaggc tagggttcct gctgggcctg gcggggcaga gacccctggttgatgcctgg

12001 caagtctctc ctcatttctg ctgtgctgtc ccctgggtgg ccaaggcgccaggcccggct

12061 gtggatctga cacctcctgc tgccgagctc tgatcagaat ctggctgcagggcagggggt

12121 gaaactgaat cccaccaggc ctcccctggc ctggatgtca cggcagacatcccaacccca

12181 cttcttggca ctgcctgacc ccagcagtgg ccttcttgga acctggagagcctgtgccca

12241 ccctgtggtg ccgaccaggc tgctgccttg gccctgggct ctgggctccagggtccccag

12301 ggatcccagg cccaggctct tgcccctccc ggctctcagg tgagctgctgggatcgggtt

12361 cctgcggttt catgtctttc attgttcttg gctggggccc ggcttatgaaactgtaatga

12421 ggggcccctg ctcccgaagc cggcccctct aaggtttcca ctgcctcggcggctgctgcc

12481 accacagccc ggagtcgggg cctgggaggg cagcagtgtg ggggcctgagccggagcccc

12541 ccggggacga gggtgctgac agtcgacagc caccaccacc accagagcccgcagcccagg

12601 taatccgaga ggaggcgggg cgcagggtgc catggccgct gtctcccaccaccaggggag

12661 ggaactgccg ctctccagag gtggggagga attggggggg gccctggaggtgagcagccg

12721 ttcccccctg gtgagcccag caccagacca gccttcacag gtgtggccttgccaaaggtg

12781 gagggagaga ggagtgggca gctggctcta gcccccgccc ttttcctggggccttgaccc

12841 tccagccctg gatcccctgc ctctccttta gtggggcaaa tctcttctgtcctccaagac

12901 cttgctttcc catctcctct accatcaaac tgcctcttcc tccctcagacctctcccttc

12961 tctcagccag cctaatcctt cctcctcgcc cttgtctttt ggccgcaaaagaccctggtg

13021 gatccttcta tccacctcgt tctggggcgc acgcacatac atgcatgtatacatgaagtt

13081 gcactcatgc aaacgtacag atcggtgtac ccgcgggacc tgcgtagacacgcatgcgca

13141 agagctcgct ccacctatgt gcacacatgt gcccccaata ccaggcctttatccacacac

13201 atacctgctc caaggcccat atgtgtacac tcacgtgtgc aggcacacaccaggtacctc

13261 agccagccct cggcttgagt cccaaggggt gcttctagcc tgatgggcagctccttgaga

13321 agtgcaggat cccccgagga gatgcctgga gactcccacg ccaccgggaggggctgtgca

13381 gggggagggg agcccccacg tgggcgctga gctgtctcct ctctccaaccctggcccagg

13441 agctcaggag cccttcaggt gctgaggtgc cctactgcga cctgcctcgatgtccacctg

13501 cccctgagga cccactcagc gcctcaacct ccggctgcca gtctgtggtggacccaggcc

13561 tcaggccagg gcccaagagg tgggtagagt cccagggccc aggaagggcttcatggggtg

13621 gaatgccctc acccttccca tttgcactcc ttccccaagg cagcacctgtctctaatggc

13681 tgctggcatg ggtcacgtgg tcagtcctct aaacctaggc acaggtgggtggtgggcatg

13741 ctccttgggc ccacaggaag aactcagatc acaccaccct gtttgcacttcagtggctga

13801 gcctcccctc cccagtcctg gctgtctctc ccaggggccc tgcccaccccataacctccc

13861 aagaccgagc tcagctttgc cccagggtgt gtggctgctg tacactcaccttgcagtggg

13921 catggccaca gcctactcac atttcctggt tccctttgca cagctttaaaagattaaaca

13981 gtccctgcac ccaggggcac ctgctgtcac ccacctacgt gggtgtgcactgctccaggc

14041 tctggggttc cttccaccct caggcctgag tggcagtccc cctttaaggtcatggtacct

14101 tgggaggcca tggtctgaga gtctagaaac ctgggttcca gcttcagatccatccctgat

14161 gggtcttgag caagttactc tgtctttctg tgtctcagtt tccctctctgtaaaataaga

14221 gggattgaat taaatcagca ttgtgctggg atcattcatg tgctcctcacaggtaggcat

14281 attaaaacaa acaaacaaac aaaaaaacag cctgggtgca gtggctcatgcctgtaattc

14341 cagaactttg ggaggccaag gtgggcggat cacttgaggt caggaggtcgagaccagcct

14401 gaccaacatg gcgaaaccct gtctctacta actatacaaa aattagccaggcatggtggc

14461 aggtgcctgt aatcccagct gctcgggagg ctgaggcagg agaaccacttgaacccggga

14521 ggcagaggtt gcagtgagtt gagatcgtgc cattacactc cagcctgggtgacacagcga

14581 ggctccgtct caaaaaaaaa aaaaacaaca aaaaaaaaaa acaaaaaaaaacccacaaaa

14641 aaacgaaaaa aaaaacaaag acagctttgt tatcaagtat gtttcagaaagtctgggata

14701 aatgaagttg aatagctttc ctgcaggact tgtcagagcc tttagcttgcctgcgtgcat

14761 cgtggctttt gggtaacgga agtagagaag tatgtcattt gactacagagctctttttta

14821 tggccatcac ttattatcat cgtgtaggcc agtctgtggg tcactctttggggatactgc

14881 cagcgctaag ccttcttgag cctgtgactt cttttaaagc agagccttctctgcagctcc

14941 ctccctcagc atctgggcta gtgaacccgt caatgcctgt ggagccatgctgcctctcac

15001 atcctcgtta gccaagcatg agtctgtctt cttagactta ctgaacttggggtcagtaga

15061 ctaagactaa gacttaaagt tggggctggg gcaatagttt tggttcataacacagctctg

15121 ccctttccta tctcggtgac cttggccagt ctcttgacct ctctgagcctcagtgtcttc

15181 ctctgtgaaa tgggaattat tattattatt attattttga gatggcatcttgctctatca

15241 cccaagctgg agtgcaatga cacgatgttg gctcactgca acctcagcctcccgagtagc

15301 tgggattcca ggcatacacc accacacccg actaattttt gtatttttatttatttattt

15361 ttgagataga gtctcgtgct gtcacccagg ctggagcgca atggcacgatcttggctcac

15421 tgcaacctcc acctcctggc ttcaagcgat tatcttgcct cagcctcctgagtagctggg

15481 attacaggtg tgtgccacca ccatgcccat ctaatttttt tatttttagtagagacgggg

15541 tttcaccatg ttggacaggc tagtctcgga ctactgacct caggtgatccacccaccttg

15601 acctcccaaa gtgctaggat ttcaggtgtg agccactgcg cccggcctaaaatgggaatt

15661 attatactta ctttaaaggg atgctgttgc tgggcgcagt ggctcacgcctgtaatccca

15721 gcactttggg agtccgagac gggcggatca cgaggtcagg agatcgagaccatcctggct

15781 aacacggtga aaccccatct ctactaaaaa atacaaaaaa ttagccaggcgtggtggcgg

15841 gcgcctgtag tcccagctac tggggaggct gaggcaggag aatggcatgaacctgggagg

15901 cagagattgc agtgagccga gatggtgcca ctgcactcca gcctgggtgacagagcgaga

15961 ctctgtctca aaataaataa ataaataaat aaataaataa ataaataaataataaaatta

16021 caaaaaaaaa agggatgctg ttttagctca atgaggcaat ccatataaaaagtctgacac

16081 agaggcagct ctcaccattg gctccctttc ccacaccagc gtgtgggccccaggctccct

16141 gtgtgagtga gtgcatatgc ctgggtgggg tgggggatgc tcctaactccccattacttt

16201 ttgggtctgt ctcctctccc aggggcccat ccccctcagc agggctcccagaagagggtc

16261 ccacagctgc ccccaggagc aggagccggg agcttgaggc agtaccctatctggagggcc

16321 tgaccacttc cttgtgtggc agctgcaacg aggaccccgg ctctgaccccacctccagcc

16381 ctgactccgc cacccctgat gataccagca actcgtcctc tgtggtgagccaggagtggg

16441 agtttggggg acaagagtgg ctcacacctc catctgcagc cctgggtcccacctaaacct

16501 ccaggccagg gctgagcctc acaccaggga atccgacgag gtcctctggaccattagctg

16561 gcagctcggg ccaccccggc gaacccctgg agagtgggga tttctgcacaggctggccca

16621 gggcagctgg ggtctggctg tgaaaagaca gggaaaggag tttcagccgacaggagctct

16681 gggtgaatca ccagcaggct cgggctgcca catgctctca gatcccagagtgttgggttt

16741 ggtgtctagc gcaagagtgg cacagggccc cagggccctg ccctcgacacacagtgctga

16801 gtcccatggc cagccctgga atagatttcc aagagacaga ggaaagggagcaggctgcgg

16861 gggtcattta accacgaaaa gagaagagcc agcagtcttt cctccagcatttgcattttg

16921 aggggctgcc gcagagcaga agagacaggc ttgtcccagg agaccccccaaaaggaaaat

16981 gacagggggt ggtgataaga ctcagaataa aacaacccag cctcacacgcttcatggcca

17041 gctccatgct aagggcttgg tgggtgtggg ctcaggggag actcaccacagcctcagaag

17101 tggagatttc agtcgcccca tatggggctg aggctcagcg gggggagcaacttagtggag

17161 gccacacatc tgggaagtag tggggctagg atttgaaccc acttttctctggcccctggg

17221 gctacctcac acagtcccac atgcggaact ctgggactct gggcaaagctcttggcttca

17281 atggatgtac atgcctccta ggtccgttga agatgagcga cttggcacttagcacctgct

17341 agagcccagc acagtgccag gcaaacagca catgctttta atttaattgattgattgaag

17401 actgggtgcg gtggctcacg cctgtaatcc cagcactttg ggaggccaaggtgggcggat

17461 cacctgaagt caggagatcg agaccagcct ggccaacatg gtgaaactctgtctctacta

17521 aaaatacaaa aattagcagg gtgtggtggt gggcacctgt aatcccagctacttgggagg

17581 ctgagacagg agaatcgctt gaacccggga ggttgcagtg agcttagattgcaccattgc

17641 actccagcct gggcaacaag agcaaaactc cgtcttaaat agagaaaaaaaaaaaagttg

17701 attgattgag acagggtctt gctccattgc ccagactgga atgcaatgatgtgaacatgg

17761 ctcactacag ccttgacttc ctgggctcaa gtgatccccc cacctcagcctcctcagtag

17821 ctgggactat aggcatgcac aaccatgcct agttattatt attttttttaattttgtaga

17881 gacagggtct cactgtgttg cccagcctgg aagtgctttt tactgaggccatggagcgga

17941 gtctacacca cagaaggtgt ggcaccactc actgtcacct cttggggacagaacttgaca

18001 gtttaggaag tgctttttat tttttattta attttattta tttttgagatggagtcttgc

18061 tctgtcacct gggctggagt gcagtgccac aatctcagct cactgcaacctctgtctccc

18121 aggttcaagc gattcgcctg cctcagcctc tcgagtatct gggattacaggcgcccacca

18181 ctatgcctgg ctagtttttg tatttttaat agagacaggg tttcaccatgttggccaggc

18241 tggtttcgaa ctcctgccct caggtgatcc acctgcctca gcctcacaaagtgttgggat

18301 tacaggcgtg agccactgcg ccctgcaggg aagtgctttg tttttttttgttttgttttt

18361 ctttttgttt tttgagacag agtctcactc tgtcacccag gctggagctcagtggcgcga

18421 tctccactca atgcaagctc cacctcccag gttcacacca ttctcctgcctcagcttccc

18481 aagtagctgg gactacaggt gcccgccacc acgcccagct aattttttgtattttttagt

18541 agagatgggg tttcaccatg tttcccagga tggtctcgat ctcctgacctcgtgatccac

18601 ccacctcgtc ctcccaaagt gctgggattg caggcgtgag ccacagcgcctggccaggga

18661 agtgcttttt aatgccaatt cccttccctt ccttctgccc ctctcatttggagagtatat

18721 gtcctgcagc cttttttctc ccgcaaacat actttctcct ccccttctctggcaggactg

18781 ggacactgtt gagaggcagg aggaggaggc ccccagctgg gacgagctcgcagtgatgat

18841 cccgaggagg cctcgggagg ggccgagagc tgacagctcc caaagggctccgtctctcct

18901 caccaggtcc cctgtgggag gagatgctgc aggccagaaa aaggagggtgagtccttctg

18961 ccaggttggt tcccatggtg atggcctggg gccccccaga tagccatctcactggccatt

19021 tgggactctg ggcacggctt actttggtgg cctgagtgtt aataatagtaacagtttgca

19081 tgtcatgatg gagcagccac aatgagttat gctacccact ttaattattattattattat

19141 ttgggatgga gtcttgctct gttgcccagg ctagagtgca gtggtgtgatctcggctcac

19201 tgcaaccttt gcctccccag ttcaagcgat tctcctgccc cagcctcccaagtagctaag

19261 attacaggct cccgccacca tgcccagcta atttttgtct ttttagtagacatggggttt

19321 caccatgtta gcccagctgg tctcaaactc ccaaccttca gtgatctgcccatcttggcc

19381 tcctaaattg ccgggattac aggcgtgatt acaggcacgc ctagcctgttattattatta

19441 ttattactat tattattttg agataagagt ctcacactgt tgcccagactggagtgcagt

19501 ggtgccctct tggctcactg caacctccgc ctcctgggtt caagagattctcctgcctca

19561 gcctcctaag tacctgggat tacaggcacc cgccaccaca cgtggctaatttgtgtattt

19621 ttagtagaga cagggtttca ccatgttggc cgggcttgtc tcaaattcctggctggggat

19681 tacaggagtg agccactatg cctggcctta gccaaggagt ttggacttctctaaatagta

19741 gggagccacc gaaggttttt gaggaggaaa gtcatgtaat taaacctgtgcctcaggaag

19801 ttccctagat caaagatgca aaggatgaat tggagcaggg aggggttgaaggatgagaaa

19861 ccagttaaga gactgttgca ggcactgtag caataactgg ttcaggcatgaatcactggc

19921 ggatgcaaaa tccctagggt gataatttgt cagcaaacag gatagtcatggtttcaaagt

19981 attgtgtccg gaattggtgg gttcttggtc tcactgactt caagaatgaagcggcagacc

20041 ctcgcgatat tacagttctt aaaggcggcg tgtctggagt ttgttccttctgatgttcgg

20101 atgtgtttgg agtttcttcc ttctggtggg ttcgcggtct cgctggctcaggagtgaagc

20161 tgcagacctt tgtggtgagt gttacggctc ttaaggagac gcgtccgcagttgttctttc

20221 ctccctgtgg gttcatggtc tggatggctt caggagtgaa gctgcagaccttcgtggtga

20281 gcgttacagc tcataaaggc agtgtggacc caaagagtga gcagcagcaagatttattgc

20341 aaagagcgaa agaacaaagc ttccacagca tggaagagga cccgagcgggttgccagagc

20401 tggctggggc agcctgcttt tattctcttg tctggcccca cccacatcctgctgattggt

20461 ccattttaca gagagccgag tggtctgttt tgacagggcg ctgattggtgcatttacaat

20521 ccctgagctt gacacaaagg ttctccacat ccccactaga ttagctagatacagtgtcca

20581 cacaaaggtt ctccaagtcc ccaacagagt agctagatac agagtgtggattggtgcatt

20641 cacaaaccct gagctagaca cagggtgctg attggtgtgt ttacaaaccttgagctagag

20701 acagagtgct gattggtgta tttacaatcc cttagctaga cataaaggttctccaagttc

20761 ccactacact caggagccca gctggcttca cccagtggat ctcgttctggggctgcaggt

20821 ggagctgcct gccagtccca tgccatgcgc ccacactcct cagcccttgggtggttgatg

20881 ggactgggcg ctgtggagca ggggcggcgc tcatcgggga ggctcgggctgcacaggagc

20941 ccacggaggc ggggggaagc tcaggcatgg cgggctgcag gtcccgagccctgcccggtg

21001 ggaaggcagc taaggcccgg cgagaaatcc agcgcagcgc tggtgggcgggcactgctgg

21061 gggacccagc acaccctccc cagccgctgg cccaggtgct aagcccctcattgcccgggg

21121 ccggcagggc cagccggccg ctccgagtgc ggggcccacc aagcccacgcccacccggaa

21181 ctccagctgg cccacaagcg ccgcgcgcag cctcggttcc cgctcgcgcctctccctcca

21241 cacctccgtg caagctgagg gagccagctc cggcctcggc cagcccaggaaggggctccc

21301 acagtgcagc ggtggcctga agggctcctc aagtgccgcc aaagtgggagcccaggcaga

21361 ggaggcgccg agagtgagcg agggctgtga gggccgccag catgctgtcacctctcagta

21421 tcacccctca gattctgcat cgattactga gagaaaggca cccttaggctggggagagcg

21481 ggaagatacc actttcacca agaggctgct cagcatcccc agagtggggcaaaccaacat

21541 aatatgcccc ctgatatgat gcatggggtc aggggagggg atgctggggtgggcacagaa

21601 tcccttccct tctaaatcgt cctgctgaaa atgcattgcc tacacctaaccccagtgaaa

21661 catcagacaa acccgaattg aaagacattc tgcaaaatga ctgggctcctcataggacaa

21721 aaagcggcta ggggactctt cttgattaaa agagactaac aggatgaggacgtggaatgc

21781 catgtgtgag cccattggga tctgggacag gaggacacag agctgtgacaggcattactg

21841 ggacaactgg ggcttgtttt tttttttttt tttttttgag atggagtcttgctctgttcc

21901 ccaggctgga gtgcagtggc gcgatctcag ctcattgcaa cctccacctcctgggttcaa

21961 gcgattctcc tgcctcagtc tcctgagtag ctgggactat aggtgcctgccaccacgccc

22021 agctgacttt ttgtatttct agtagagaca gggtttcacc atgttgagcctgatgggatc

22081 cgggacacgc ctatagtccc agttactcgg gatgctgagg caggaggatcgcttgaactt

22141 gggaggtgga ggttgccgtg agctgagatc gccccactgc actcccgcctgggcaacaga

22201 ataagactcc atctcaaata aataaataaa taaataaata aataaataagggccatggtt

22261 gtggggtgag gaggggacag agaaggagag aggtttagga ggcagacttgatggtacttt

22321 ggacaggagg atacacagtc acagctcctg gcctgggtgt ctgggtagatggtgtgccct

22381 ttgctgagag caggtggctg gggagcggat gggcccagcg ctggctgtgctgtgtgggat

22441 ttgcgagccc tgaggaagag gttttgaggc ttcagatgct cagggaagcaggggatggag

22501 atgtggcatc ttcaactgag gagcaatgtt cactcaggca ctcagcagacgtttacttac

22561 tgcccacaag tcaatcatgg ctgaatagat gaggcagcaa tgagaacagcagcagcatta

22621 cagcagtgac ctgttttttt gatgttccag gccttgtgct aaataaatgtcttgcacaga

22681 atcactctgg gctccccgat ccctcactcc tggtctgcct ccttcctcacgggccactcc

22741 acctcgctct cctttgctga ggccgcctcc tctgcttcac ttttaaatatctgatgcccc

22801 acatcccagt cctgggcccc ttctgtcttc tccctgcaca cttagctgcttggctttcgg

22861 tactgtctgg gaaaaaccat gactccggag tccacatctc tggccttgatttctcccctg

22921 aacctgccaa tttatacaac ccagccctct actgcgttaa tcacacctcaggccccacac

22981 tgcactcact gtttcactca tccccccccg cccttttttt tttttttttttttttttttg

23041 agacagagtt tcactcttgt tgcccaggct ggagtacaat ggcgcagtctcggctcactg

23101 caacctccac ctcccaggtt gaagccattc tcctgcctca ggctcccaagtagctgggat

23161 tacaggcatg caccaccacg cccggctaat tttgtatttt tagtagagacggggtttctc

23221 catgttggtc aggctggtct cgaactcccg acctcaggtg atccgctgatccgcctgcct

23281 cggcttccca aagtgctggg attacaggcg tgagtgaccg tgcccggcccactgctacaa

23341 tactattaac taagctacag acgtgatggg attcaccagt ttttctactaatatcctttt

23401 tctgttccag gatccattcc aggatcccac attgccttta gtccctctcctcatctcctc

23461 cgtctcctcc aatctgtgac aggtttccca tctcttccag tttcccctgaaggctggggg

23521 cacagcgatc tgctcacctt tgactttaaa aaaagtctcc ctggatgaacaatgacattg

23581 gccccagagt gcccaggctt gggggctact gcaaccatcc aggagagaaatagtggtggc

23641 ttggagtagg aagtgggtgt agatgagaga aacaggtgaa tatggaatgtatttatttta

23701 tttttcgtag agatgggggc tcactatgtt gcccaggctg gtctccaactcctgggctca

23761 agcaatcctc ctgcctcagc ctcccgaaat gttggaatta caggtgtgagccactaccag

23821 gcatgaaacg tattttagaa tgccatggga catcagccac cagcaattttttttgttttt

23881 tgttttctga gacagagtct cgctctgtca cccaggctgg agtgcagtggccagatctca

23941 gctcactgca acctccacct cccgggttca agcaattctc cagcctctgcctcccgagta

24001 gctgggatta caggcatgca ctactgcatc cggctaattt tttttttttttttttgtatt

24061 tttagtagag atggggtttc accgtgttag cagggctggt atcgatctcctgaccttgtg

24121 atccgcccgc ctcggcctcc caaagtgctg ggattacagg catcagccactgctcccggc

24181 tgcatccagc taatttttgt atttttagta gagactggtt tcaccatgttggccaggctg

24241 gtctcgaact cctgacctca gatgatccac ccgccttggc ctcccaaagtgttagcatta

24301 caggcgtgag ccaccgtgcc tggcaacctt gcaaattttg aattccctgctaggtgctgg

24361 gaactcagac tttcaccaac accagcccag agaggctgga cgaggcagtggctgcaaagg

24421 gagaggacag gggatcttaa gaaggcgtga agggagggga tctgcatgaaggcaactgtg

24481 gctacttttt tgtttcgttt tttgttttaa gacaatgtct tgctctgttgcccatgctgg

24541 agggcaatgg cacattcttg gctcactgca acctccacct cctgggctcaggcactcctc

24601 cggcctcagc ctcctaggta gctgggacta caggcacgta ccaccaggccctgctaagtt

24661 ttaaaaaact tgtagtagag acagggtctc gccatgttgc ctaggctggtctggaactcc

24721 tgagctcgag tgatcctccc accttggcct ctcaaagtgc tgggattacaggtgtaagcc

24781 accacaccca tagttgtggc tcctttaaga tgaggccatg ataccctttactcttcacct

24841 aaagcagtag ccaagggaca tgtacatagg ggtgctcaac acctgcttggtgaccgaggg

24901 attgagcggg gtggagggtg acacaccaag gtcatggcaa ctctgtcatgaggctaggag

24961 ttgcaaagag ggtcactact gaggacagtt acattaatcc tttaggccagtgcttctgaa

25021 actataaggt gtacaaatca ccagacagtt ttgttaaatg cagatccagaagcagtgcat

25081 ctgggctggg acctgagatt ctgcatttct ggcaaactcc cagctaccagtttataaaag

25141 gttgtccatc cctgcacctt tcctatcctc atggcagccc taggagaagcctcagggtag

25201 gaacatttgg atacaaaaaa acaggggctt tctagagctg tcgcacaggaaacaggctca

25261 ttagaacctg tctctactaa aaacacaaaa atgagctggg catagtggtgcatgcctgta

25321 atcccaacta cttgggaggc tgaggcagga gaatcatttg aacccaggaggcttaggttg

25381 cggtgagccg agatcgcgtc attgcactct agcctgggtg acagaacgagactctgtctc

25441 aaaaaaaaaa aaaaaaaggt cgggcatggt ggctcacgcc tgtaatcccagcactttggg

25501 aggccgaggt gagcggatca cctgaggtca ggagttcgag accagcctggccaacatggt

25561 gaaaccccgt ctctactaaa aatacaaaaa ttagctgggc atggtggcgcatgcctgtaa

25621 tcccagctac tcgggaggct gaggcaggag aatggcttga acctgggaggcggaggttgc

25681 catgagccga gatcacgcca ctgcactcca gcctgggcga cagagcgagactctgactca

25741 aaaacaaaac aaaacaagaa atggggggaa ttccttggat tctgattgaaggaaatagaa

25801 ctgggaaggg aagactgtca ggtggctgct gttgggccca cctctccctccctggggtca

25861 cacaggccat tgtcaacact tctctccaca aatttgcttc ttctctgtcttgtccgtgga

25921 tccccagacc ctgtggcctt ccagttcttg aacccatctc ttgagtgagtcagggtctca

25981 atttcaaatt cttgacctca gcttgagaga ggcatccaag cccttgtctaatcagccttg

26041 gtcagagagg tggagtcact tggtacagac agtgagacct gtaggaggagggtgtggggt

26101 ttgccctaat cactggtcct aagggacaaa gaaaggtaga atatgagagctgcctggacc

26161 tctcccctta ccttgagccc ctctcttctc tctccagaca ccggcggtgggggccggagc

26221 gcaggacagc actgggcaag gctccgggga gaaagcgggt tgtccctggagcggcaccgg

26281 tcaacactga cccaggcttc ctccatgaca ccacacagtg gacctcgaagcaccacgtct

26341 caggcttctc ctgcccaaag ggacactgct caggctgcct ctacacgtgaaatccccaga

26401 gcctcctctc cccatcgaat cacccaaagg gacacctcca gggcctcatccacccaacag

26461 gaaatctcca gggcctcatc cacccaacag gaaacctcca gggcctcatccacccaagag

26521 gacaccccta gggcctcatc cacccaagag gacaccccca gggcctcatctacacagtgg

26581 aacaccccca gagcttcctc tccctcacga agcacccaac tggataaccccagaacctct

26641 tctacccagc aggacaaccc ccaaacttct tttcctactt gtactccccagcgggaaaac

26701 cccaggacac cctgtgtcca gcaggacgat cccagagcct cctctcccaacagaaccact

26761 caacgagaga attccagaac atcctgtgcc cagcgggaca atcccaaagcctccagaacc

26821 tcctctccca atagagccac acgagacaac cccagaacat cctgcgcccagcgggacaat

26881 cccagagcct cctctcccag tagagctaca cgagacaacc ccacaacatcctgtgcccag

26941 cgggacaatc ccagagcctc cagaacctcc tctcccaata gagccacacgagacaacccc

27001 agaacatcct gtgcccagcg ggacaatccc agagcctcct ctcccagtagagctacacga

27061 gacaacccca caacatcctg tgcccagcgg gacaatccca gagcctccagaacctcctct

27121 cccaatagag ccacacgaga caaccccaga acatcctgcg cccagcgggacaatcccaga

27181 gcctcctctc ccaatagagc tgcacgagac aaccccacaa catcctgtgcccagcgggac

27241 aatcccagag cctccagaac ctcctctccc aatagagcca cacgagacaaccccagaaca

27301 tcctgtgccc agcgggacaa tcccagagcc tcctctccca atagagctacacgagacaac

27361 cccacaacat cctgtgccca gcgggacaat cccagagcct ccagaacctcctctcccaat

27421 agagccacac gagataaccc cagaacatcc tgtgcccagc gggacaatcccagagcctcc

27481 tctcccaaca gaaccaccca acaagacagc cccagaacat cctgtgcccgacgggacgat

27541 cccagagcct cctctcctaa cagaaccatc caacaagaga accccagaacatcctgtgcc

27601 ctacgggaca atcccagagc ctcctctccc agcagaacca tccaacaagagaaccccaga

27661 acatcctgtg cccaacggga cgatcccaga gcctcctctc ctaacagaaccacccaacaa

27721 gagaacccca gaacatcctg tgcccgacgg gacaatccca gagcctcctctcgcaacaga

27781 accatccagc gagacaaccc cagaacatcc tgtgcccagc gggacaatcccagagcctcc

27841 tctcctaaca gaaccatcca acaagagaac ctcagaacat cctgtacccgacaggacaat

27901 cccaggacct cctctcccaa tagagccaca cgagacaacc ccagaacatcctgtgcccag

27961 cgggacaatc tcagagcctc ctctcccatc agagccaccc aacaggacaaccccagaact

28021 tgtattcaac agaacatccc cagatcatct tctacccaac aagacaaccctaaaacctct

28081 tgtaccaaac gagataacct cagacccact tgtacacagc gggaccgcacacagtccttt

28141 tcctttcaac gagacaaccc tggaacctcc tcatctcaat gctgcacccaaaaggagaat

28201 ctgagaccat catctcccca ccgctccact caatggaaca atcccaggaattcatctccc

28261 catcgtacta acaaagacat cccctgggcc tcgtttcccc tccggccaactcagagtgat

28321 ggtccccgaa cctcttcccc atctcgctcc aagcaaagcg aggttccctgggcatccatc

28381 gccctccggc caacccaagg tgacaggcct cagacatcct ctcccagcaggccagcccag

28441 catgacccac cccagtcctc ctttggcccc acccagtaca acttgccatcccgggccacc

28501 tcttcctccc ataacccagg ccaccagagc acctcccgaa cttcctcacctgtgtacccc

28561 gctgcctatg gggctcccct gacctctcct gagccctccc agcctccatgtgctgtgtgc

28621 attgggcacc gggatgcccc tcgagcctct tcgccccctc gctatttgcagcacgacccc

28681 ttccccttct tcccagagcc ccgcgcccct gagagtgaac cgccccaccacgagcctccc

28741 tatataccac ctgctgtgtg cattggacac cgagatgccc cccgggcgtcctcgcccccc

28801 cgccacaccc aatttgaccc cttccccttc ctcccagaca catcagatgccgagcatcag

28861 tgtcagtccc cccaacacga gccccttcag ctccctgcac ctgtgtgtattgggtaccga

28921 gatgcacccc gggcctcctc cccaccacgc caggccccag agccttccctcttattccag

28981 gacctcccca gggccagcac agagagcctt gtcccttcca tggactctctgcacgagtgc

29041 ccccacatcc ccacccctgt gtgcattggg caccgggatg caccctccttctcatcccca

29101 ccacgccagg ctcctgagcc atccctcttc ttccaggatc cccctggaactagtatggag

29161 agcctggccc cctccactga ctctctgcat ggctccccag tgctgatcccccaagtgtgc

29221 atcgggcacc gggatgcacc ccgagcctcc tccccacccc gccacccacccagtgaccta

29281 gcgttcctgg caccctcacc ttcaccgggc agctctgggg gctcccggggctcagcgcct

29341 cccggggaga ccaggcacaa cttggagcgg gaggagtaca ctgtgctggccgacctgccc

29401 ccacccagga ggctggccca gagacagcca gggccccagg cgcagtgcagcagcgggggc

29461 cgcacccaca gccctggccg tgcagaggtg gagcgcctct tcgggcaagagcgcaggtga

29521 gcccgggggt ggggtcagcc aggtgggctg gggaggaggc tcggcagcaggacaggtgaa

29581 gggttagggt gccaaaagaa agtgttcaaa tccccctggc ttgccatttaccggctgtgt

29641 gaccttgggc aaatcgctcc atttctctgt ttctgcatat tgggagttttctgttttgtg

29701 tgtgtgtgtg gttaagtgat gtcatgcaca gcccagtggt taacagcaaagactgcagtc

29761 aggagggctg agtccaaatc ctgggtcaaa gccacatgtc aactcgtatgacctgatata

29821 gtgagttaac ctacctgagc ctcagtttcc tcatctgtaa gggaggggaacatgagcaca

29881 ttcattcaaa taagggtgaa ctgtcttttt attttttatt ttttgtttttttttttgagg

29941 tggagttttg ctcttgttgc ccaggccgga gcgcaatggt gcaatctcggctcactgcaa

30001 cctccacctc ctgggttcaa gcgattctcc tgcctcagcc tcccgagtagctgggattac

30061 aggcacgtgc caccacaccc ggctaatttt tttgtatttt tactagagacggggtttcgc

30121 catattggcc aggctggtct cgaactcctg acctcaagtg atccacccgcctcggcctcg

30181 caaagtgcta ggattacagg agtgagccac cgtgcccggc caaaatgagagtgaactctc

30241 aaaccctttg atccagactc atgggttttt tttttttttc ttccgtgcatgagggagaag

30301 aagaaagtac ccatgatttt ttcctgcctt ggcaaagaaa actcatgggtccctatgcat

30361 ttcagaaaac agttatgtca atttaaaatg tatggccagg gccgggcacggtggctcatg

30421 cctgtaatcc cagcacttgg ggaggccgag gcgggcggat cacaaggtcaggagatcgac

30481 agcagcctgg ctaacacggt gaaaccccat ctctactaaa aatacaaaaaattagctggg

30541 catggtggcg ggcgcctgta gtcccagcaa ctcgggaggc tgaggcaggagaattgcttg

30601 aacctgggag gcggagcttg cagtgagccg agatcgtacc actgcactccaacctgggtg

30661 acagagtgag actccatcta aaaataaaaa taaaataaaa atgtatggccagagctacct

30721 attttaagaa agaaagctca cagaattatg gatttttagc agtcaaacatcctgggacac

30781 ctgaagtcca ggtgtctttt gagtctcctt ggtcagcagc actggccccctggaagggga

30841 gcatttcctc ctgatcaggc tgaggtttct ctccccagaa gttccagccctcgagttttc

30901 aagaatcaga gctagaattc cattagttag ggtcaagaga acaacagcaacaaaaagcag

30961 tctggaagtc tcaaaacttt ccatgtatat aattcaacga atttttagtttatttaccaa

31021 gttgtccaac cattgccaca atctaacttt agaacatttt catcaccctaaagggtatgg

31081 aatattttgt atctaaaatt cctctttgct gctccttggg aaagttttctcctggatttg

31141 aatctgcatg agaaacctta tcagtcttgg ctgggtgcag tggctccctcctgtaatccc

31201 agcactggag cttgcagtga gccaagatca tgccactaca ctccagcctgggtgacagag

31261 tgagactccg tctcaaaaaa aaaaaaaaaa aaaaaaatta gccgggcatagtggcacacg

31321 cctgtagtcc cagctactca ggaggctgag gcagcagtat tgcctgaatttgggaggtgg

31381 agtttgcagt gagctgagat tgcgtcattg cactccagcc tgggcaacaagagtgaaact

31441 ccatctcaaa aaaagaaaaa aaagaaactt tatctcttgt tcttcaaatttccttttcca

31501 gtaagcttga tcatttaata tccagatgac aaccgtgtgg tctccagcattagtataatt

31561 ctttctttgg ccttaaaaac aaaaacccag agcagtttta ggtttacagcaaaattgagc

31621 agaaagtgca gtgttccatg cacagcctct cccactacca atatcctgtactagataggt

31681 atgcttgttt ccagctcctg gcctcaaggg atcctccttt cttggcctctcaaagtgctg

31741 gtgagccact gtactgggca gtagggtgat acatttgtta caatccatgaacctacacta

31801 tgaaatcacc caaagtttag ggttcactct tggtgatgta cagcctataggcttgaatga

31861 atgtatgaca agtatccacc attgtaacat catggagtag tttcaccctgaaagtcttca

31921 gtgtctttaa cttttttttt tgtttggaga tggagtctcg ctctgtcacccaggctggag

31981 tgcagtagtg caatcttggc tcactgcaac ctctgccttc tgggttcaagcagttctcct

32041 gcctcagcct cccgaggagc tgggactaca ggagcatgcc gccacatccggctaattttt

32101 ttgtattttt agtagcgaca gggtttcacc ctgttgccca ggctagtcttgaactcctga

32161 gctcaggcaa tctacccacc tcggcctccc aaagtgctgg gattataggcgtgagccacc

32221 gtgcctggtc tgaccttttt tttttttgaa acagggtctt gctttgtcacccagcagtag

32281 tgcagtggcg tgatcatggc tcactgcggc ctcaaactgc caggctcaagcgattctctc

32341 acctcagcct cctcagtagc tgggactaca ggcgtgtacc actatacccagctaattttt

32401 ctactttttg tagagatgga gtctcacttt gttgcccagg ttggtctcaaactcctggcc

32461 tcaagcaatg ctcccacctt ggcctcccaa agtgtctttg acctttttatgattactatt

32521 tcttgtctaa tgtcaatttt cctaactttg tcttaactaa taactcagcagggacattaa

32581 ggtctttaag ccaaagttaa ttaattttct ttcctttttt ccaggataatttcagagaga

32641 taaggtgttt atattaataa tagaaatgag aaatatgttt acacttttattaaccatttg

32701 tttttacacg atcactccta tacatttaat tctactctct ttgaaatagcttatttacct

32761 tttagggaag ttttcataat tttactgaat aattaaaatt tttcctcttatctggcacct

32821 tttccaagta gaaaaccatt catcctctga atatggaaaa ttttaaaactgtgcagtgtg

32881 tgtgtaaggg acagactgga gcttatgagc gggtggctgt aggagtgtgcttttattttc

32941 tcctatttcc tcatcgatat gtatttattg agcatctact ctgtccaagcattgtcccga

33001 gtctggaaaa tttttcttaa agggttgtca catcaaagca ttgggagttttggcttgatc

33061 ttaatttttt tttccttaga tgcctttggc atctcttaga gtcacgtagcatcctgtggt

33121 catttgaatt caaaacctag ccttcactgg atttgctaga cttgatggctttgctccttt

33181 aattctctct ggaggtcgaa gaacccatct aagcttccga aggaaacgtttcctttgtca

33241 tgcttggtgc ggccacatca accctcggga acaggtggcc ccgaggagacgctgttgctt

33301 cagcatcgga caagccaggt ctctgttggg gtttcagaat cttcttgagtccctcactct

33361 tttctctcag ttctacatgg gggaaaaaag gaaggcgagt tctcaggaggaatgctcatc

33421 aagcaagctg gagttcgtat ggaaaatgca tccatccgga agagaacacacaagtgcctt

33481 gcttccctgc accgggtgtt tccactattg tcctcctggt cctccccattagggaggaac

33541 agcccactgg gtcacgtctg ggctcttgct tcatcgaagc tcctataccccagttcgggg

33601 gaaaattcac tctaaggcct tcagctctca cagagtaagg aaacgcactcacctccaatt

33661 agattacaaa ttggctgggt gcagtggctc atgcttgtaa tgccaagactttgggaggtc

33721 aaggcaggtg gattacctga ggtcaggagt tcaaaatgag accagcctggccaacatggt

33781 gaaaccccgt ctctactaaa aatataaaaa ttagctgggc atggtggtggacacctgtaa

33841 tcccagctgc tcagcaggct gaggcaggaa aatcacttaa aaccagaaggcggaggttgc

33901 agtgagctga gattgcacca ctgcactcca gcctgggtga cagagcgagactccatctca

33961 aaaaaaaaaa aaaaaaaaaa gttacaaaca gcctgcccag ggagccctcaagctcagaaa

34021 cacttcctcc agggaacttt ggttcctctc cgaaccagct gccaataactgctaacaact

34081 aacattattg tgctttatgg ctctgattct aatgacattg gcaaaagacatgaaacaaca

34141 aaaaactcca accccatact ttttttttga gacaggatct tgctctttcacccaggctgg

34201 aatgcagtgg catgatcatg gctcactgca gcctcaacct cccaggctgaagcgatcctc

34261 ccacctcagc ttcccaagta gctgggacta cagccacgta ccaccatgctcggctcatta

34321 aaaaaatttt tttttcctag aacaaggtct cattctgttg ccagggctgtctcaaactcc

34381 tcgactcaag tgatcctctg acctcagcct ccccaagtgc tggaattacaggtgtaaaga

34441 cactgtacct ggcctcccaa ccccatatat atatatatat attttttgagacagggtctc

34501 actatgtcac ccaggctgga gtgcagtggc gcgatctcag ctcactgcaacctccacctc

34561 ctggggtcaa gcgatcctcc tgcctcagcc tcctgagtag ctgggattacaggcacgtgc

34621 caccacgcct ggctaagttt tgtattttta gtagagattg ggtttcactatgttgaccag

34681 gctggtctcg aactcctgac ctcaagtgat ccacccacct cagcctcccaaagtgctgtg

34741 attagaggca tgagccacca cacctgggct aatttttgta tttttagagactaggtttca

34801 ctatgttgtc taggctggtc ttgaactcct gagctcaagc catccgcctgcctcagcctc

34861 ccaaagttct gggattacag gcgtgaccca ttgcgccctg cccaatcccatacttttgaa

34921 ggtgtcgttc cagcatggct cctcaggcac aggcccacca cagacagcagggcctatgga

34981 ggcctgagca gagtttcctc atacttccct ttttgctgcc tcactctgggtccaccacag

35041 ggtggccttt ttcaggcttc tcttcctggt tcagttcatc gaccaaagacatggctccat

35101 ttgctaactg agacccaacc aaaataaaca ttcatggagt ggttgggccttttgttgtga

35161 ccccttaggt agaggaaggg agagatatgc ccaggttctg tttggtgtttctacctgtca

35221 atagagatac cacgttaatc attaacagcc atgcctccca gttagtaagcaagacaacta

35281 actggaacta gactttttac acaagttaga gatgatcttc atcggatgcgtcaacaatgc

35341 ctgaagccca gtgtcttaga aacaacactt gcccagggtc aggcgtggtggctcatgcct

35401 gtaatcccag ctacttggga gattaaggca gagaatcact tgaacccgggagatggaagt

35461 tgcagtgagc cgagatcgcg ccactgcact ccagcctggg tgacagagcgagactccatc

35521 tcaaaaaaaa aaaaaaaaaa aagacacttg cttggacagt ttatgttggcctctctgaag

35581 ttgtcaggga gaatgtttct ttcttctgat cttgctcaga gctcttttgccaacagctag

35641 gatggcctgg agttttcaag gctaagcgct gggattctgt tggttaacagtgatgggagg

35701 gaaaaaggaa aagaaatcca aaatttacaa tatggacagg aaaaggcagaaagaatggaa

35761 cacgggggca cacagcagtc tggctctgtc gtcccacctc gtgggctgcgatcatgatac

35821 aagtgcttgg cccctggaac ataagaagca ctcaataaat gctttgtcataatgattatg

35881 tgtgcccagt gcctggtaca cagtaggtgc tcaataaatc ttaattcccgcaaagaccag

35941 tctaaccttt gtctgggggt ggctcttggg ctgctggtgg ggtggtggttagtcatagga

36001 agtactggat gagacaggag agggccatgg ccagggccag atccccctccccacccaacc

36061 gcctctactc cccacttttc tcgtcatgtt cgcaagagcc tcatgaggcagaatagagca

36121 gtgttaacca tccccatttt tcagaagggg aaactaaggc cctgagagtcatcctcactt

36181 agggcccttc aacgagcttg cagtgggtcc ctggctgtcc cacatctcctcctgttggag

36241 gtgggagcag aggggctggg gtgctgggag tgggacagtc cctcagaggagtggctgcat

36301 ttgctcatag gaagtccgag gcagcggggg ccttccaggc ccaggacgagggacggtcac

36361 agcagcccag ccaaggccag agccaacttc tccgaagaca gtccagccctgcccccagca

36421 ggcaggtgag cactgccagc tgtctggggc cccgcacccc aaggggcggccactgcctct

36481 tccctcccgc tagaagccag gcagggggct tggacaggaa ggtcctctatgaaagggtcg

36541 gagtccaatc atggggatcc agctctcccc tctccccaac ggccagcagctcttggcaaa

36601 atgcacaaga ccccacatta atcctttgaa gatagcccct ctcccacgctatccccttcc

36661 tttactaagc actgctgtct tttttttttt tttttttttt tgagatggagtcttgcactg

36721 tctcccaggc tggagtgcag tgggacaata ttggctcact gcaacctctgcctcccaggt

36781 tcaagtgatt cttctacctc agcctcccaa atagctggga ttacaggcgtgtgccaccac

36841 acccaactaa ttttcgtact tttagtagag acagggtttc accatgttggccaggctggt

36901 cactcctgac gtcaagtgat ccgcccacct tggcctccca aggtgctgggattacaggcg

36961 tgaaccacgg cacctggcca atactgctgt cttgagcaga tttcagggaaagccttgaag

37021 caagaatctg gctctaaggg ccctctcttt cagggtaatt tgtatctttaaccaaaccca

37081 gagggctagg cccgcctcag tggaatgggg tattggtggt ggaggttctggcacctgata

37141 gcccaagttg gaatcagtat ctttgagagg ggtgagaagc caagaacgggggcaggtctt

37201 tgcagatctt tttctggaac tgaggaaagc gggtgaaagg gaggagctgaccccggaggg

37261 gtggggcaga gaccctgtgt actttttggc ctgctttgat tcaggctgctgtgtggacac

37321 agccttgact ctctgggggc ctaagaaagg cagagctggc agccaggtccccagagagag

37381 agcctcacct accccctcac ctcatcccca ggtgaccatg ctccctgccaaacaggcaga

37441 actgacccgg cggagccaag cagagccccc tcatccttgg agtcctgagaagagacctga

37501 gggagatcgg cagctccagg ggtccccgct gccccccagg acatcagccaggacccctga

37561 gagggagctg cggacacaga gacctctgga gagtggccaa gcaggcccaagacagcctct

37621 gggggtgtgg cagagtcagg aggaaccgcc agggtcccag ggccctcatagacacctaga

37681 aaggagctgg agcagccagg agggaggcct gggccctggg ggctggtggggatgtggaga

37741 gcccagcctg ggggcagcca aagccccgga gggagcatgg gggggcacttccagggagta

37801 caaggagagc tgggggcagc cagaggcctg ggaggagaag cccactcatgagctccccag

37861 agaactagga aagagaagcc cactcacgag cccccctgag aactggggaggccccgcaga

37921 gtcctcacaa tcctggcact ctgggacacc cactgctgtg ggctggggggcagagggagc

37981 gtgtccatac ccgcgtggct ctgagaggcg acccgagctt gactggagggatctgcttgg

38041 ccttctccgg gcaccaggag agggggtctg ggcccgtgtc cccagcctggactgggaggg

38101 cctcttggag ctcctgcagg ccaggctgcc ccgcaaggac ccagctggacacagggatga

38161 cctggccagg gctttagggc cagagctggg tcccccaggc acaaacgatgtccctgagca

38221 ggagtcacac agccagccag aaggctgggc cgaggccacc ccagtcaatggacacagccc

38281 cgcactgcag tcccagagcc cggtccagct gcccagccct gcctgcacctccacccagtg

38341 gccaaagatc aaagtgacaa gaggaccagc gaccgcaact ctggcaggcctggagcagac

38401 gggccccctg gggagcagga gcactgcgaa gggccccagc ttgccagagctgcaggtaag

38461 gaggtttcca ccctcccaag ggtagccaga aagtcagccc cactcagccaagtctccttg

38521 gaaaagcctc cccttggagt agcctaagct cctgcatccc cctccaggctcagacctcag

38581 cctccctgct gaccacaacc catcccgatc accaaactgg cccaacaatgatgatgagca

38641 acacagtttt aagcgtttat gggccaagcc ctgatctgaa tgtttgacgtgtgcttttcc

38701 catttagtct ccttagcaac caggtgagaa atacactatt tacagataaggaaactgatg

38761 cgcagggtga agccacttgc tggtggggca tgggcaaaac ccaggtctgctcagtgcaga

38821 ccacactgag gcctcaagca agatgctctg gccagggcct attcccctcctggctccacc

38881 atacctggtt tatgttgtgt ctggtggcac acacctgacc ccacctgggactgtagccag

38941 tgtgggcatg ccccttcccc tggtggtact caggtacctg agtccaggacagcctcgctt

39001 accctctctg gcccctacag ctcctctcag acacagagaa gagggtgcatcaatgctcac

39061 tgggttcagc tagctgccaa gacaggctgc ttaaatgagg gtcgtgtgcaaagtgggccc

39121 agcgccgggc acacagtagg tgctcgccct tcccctgctt cactggtgctttggtgctgc

39181 cttgaagccc agaacattct tcatctgaag atggtgggca gggagggtcttggaggccag

39241 aatcctgcac cctggcaata gctcattggg aggacggcat gtggttttgaacaccagcct

39301 ctctctctct ctgtaagatg gaccaaccac ttctctgacg ggcagcgctggggtgccgtg

39361 ggggttcctg cttgtttctc caaagcctcc tcatctccta gatgcaaagtccaacgccac

39421 ctgccccagg atgagcaggg cttccaggca tcagggtgca ccccgtgctgggcccagggc

39481 cttgccatat gtgcctcaag tggataggag gcagctgcca cttgacagatggggaaactg

39541 aggctcagac tccttaggca tttgctgggg gtcacacatg cataggtcgtgagaaatgag

39601 atcaaagcat ccactccaaa gtttgtgctt ttatttttat ttatttatttacttattgag

39661 acggagtttc gctcttgttg cccagactgg agtgcaattg cacaatctcagctcactgca

39721 acctccgccc cccaggttca agctattctc ctgcctcagc ctcccgagtagctgggatta

39781 caggcatgtg ccaccatgcc cggctaattt tgtgttttta gtagagatggggtttctcca

39841 tgttggtcag gctggtcttg gactcctgac ttcaggtgat gcatccaccttggcctccca

39901 aagtgccggg attacaggtg cgagccacca tgcccggcct aagtctgtgcttttagccac

39961 cacgtcacaa agctcctgag cccatgggag gactggagaa ccctctcccctgtatttccc

40021 tgtggctttg atgagttgac cctccaatca actcaatgcg tggacatcagagaagcaggg

40081 ataagtcagc tcgtcctgcc ctcagattgc tgtcaggctt gttaggaaggcacacagaca

40141 gctcaaggag gacacggtgc tgtgtcccgg ggcatgctgg gtgccacaggccggccaggt

40201 caagaaggaa gttagaaaga ttcttcagtt tcatggtgaa gctcagggttctcaggaggc

40261 taggagatgg tggctgggaa gggatgggag caccatgtac tgaaaggaatttcacagatg

40321 acaaaacgag taaccaccag gtcctgctgg ggctccagct gctcctctctatgaaaatcc

40381 ttggcttggc acagctgggt gcagtggctc acatctgtaa tcccagcactttgggaggct

40441 gaggcaggca aatcacgagc tcaggagatc gacaccagcc tggctaacacggtggaaccc

40501 cgtctctact aaaaatacaa aaaattagcc gggcgtggtg gcgggtgcctgtagtcccag

40561 ctacttggga ggctaagaca ggagaatggt gtgaacccgg gaggtggaagttgcagtgag

40621 ccgagatcac gccactgcac tccagcctgg gtgacagagc gagactccatctcaaaaaaa

40681 aaaaaaaaaa aaatccttgg catggcactc aaggccggct tcccttccttccactccgga

40741 tttgcctcat tggtgctgag ctggctgcag ggcctgtgag cacatatccctgcctttgca

40801 catgctcttc cctgttcagc caccaaacgc ctgttcattg tcgaagtcttaggtcaggct

40861 ccctgtcctg agaagccttc cctgaacagt cactcctagt aatggtccccttctgggctt

40921 ggcagttttg cttccatttg tccatgcaac atccatctaa tagggttgtcatttccccat

40981 aagctccaca caggcaggat ctctacctgc tttatctctg taactctagctctggcccag

41041 ggcctgacat aaaggagggg acagctcagt ggatgcatgc aagatggaggacacaggggt

41101 cagtgggtga acaatgaatg aatggagggt gaatgtgtga atggatgatggatcaatgat

41161 gcatgttgaa tgaataatag acatcttttg gatggatgac agatgggtgatgatggatgg

41221 atagctgggt gatgaatata tggtggtggt ggatatatga tggatgttgcttaggtgatg

41281 gatggatgaa ctttgggtgg aatatgaatg gatagatgtg gcatgggtggatgaatgtca

41341 gatgatagat gttggagata tgggtagatg gatgatggat ggagagagggatatgtaggt

41401 attgggtaaa tggatatgtg atggatcaat ggagggtaga tacatgaatgggtgatagac

41461 aatggatgat gggtacatga gagggtgagt catgtgatag acactggatggttggatgga

41521 tacatggatc tactgatgct ggacgttaga tgggtgttgc atggacagatgatagaatgg

41581 atggatgagg tggacagatg catgcatcct ggagaataag ttgggctaagctgtgttctt

41641 tttttaatct ccagttccaa ccagaggagc ctgaggagtc agaaccaagcagaggccaag

41701 accccctgac tgaccagaag caggcagact cggtagctgg gtcatgggtgtgggtacata

41761 cggtggggaa gggaggggga agcaggttgg agatgggctt cattcctcagaagagcccta

41821 gaatcaacca gaccaaagtt ggcattgcca tggggtcatc tatgtgcatggtggggcctt

41881 aagaagaggg gctctgcagg agccaccttc tggcttgggg acctgggtaggtgggcgatc

41941 ctggggtcag aaccctaggc catgcttctc atttgctggg actgaaaaggtcaatgtctt

42001 tccctgcgca aatgatggtt tggccccagt ggtctctgtg ggaagagatccttccggttt

42061 gaaagggcca ggccaggctg aaagagcagg gcttccacga gcaggagccagagagctgag

42121 gatgtaccca gtcagccagg cctggagggt ctccagggtc ctggaggcgggagagatatg

42181 tgcgggggtg ggacccacgg atgctgctct gaggcctggc tgcagctggtgagcacaact

42241 ctgcccgccc ctccccgtga cctaccaaac agactgttct cgtcaccctcagcctccaga

42301 gaggtgagat cagagttgag ggccgtgggg cagtgggagg tgggggaggaggagacagac

42361 tgtttggggc tgtgttttcc ggtcctgctc ttcctcccgt tgcctcctgaagccaggggt

42421 ggcagggagc gtccattggg cagcatagcg ccccccaagt agggccctgccgtgagtcaa

42481 agctggggga attctgccca aaccctcact gtgcagatga ggaaatggaggcaggggagt

42541 cgtcccaggt tatacagtca gtggctagct ggactgggac tagaacccagggcccaggaa

42601 ccacccagcg ctctctctgc acctccacct ggcacccatg ctgcccccgtccctgccccg

42661 atttcttgcg tggcttcgaa cggcagtgct gtaacttcga gcagtccagtcttcccatct

42721 gtggaatggg cggggacagg ggacactggt cgctaaaggc gctgccagccctcccaggga

42781 ctctgacaac tttgctcttc ctctttctgg gttatttctt catatcctggagccagagta

42841 gtgaacgagg cggaaacagc aatgccgggg tgcccctcta gtctccatgaaacgggcccg

42901 gcccatcaac gtggaaaata tctcaaccta cccccacccc taggcagccttgactggtca

42961 gaactgataa ccacctcatt catgcattct ttcacacaca cttagtgagcaccttctgta

43021 tacccaggtg tgggtcacag gtgagtcgga gcgccatcaa agagttcagtctagtgagat

43081 ggttgcatgc ctgtggtcag gactgtgatg gggaatgtgg tagcagggtcgggggcaccc

43141 ctacccccaa agccctcctg gacctgtgct ttgatgcttc aagttccacttccaaagagt

43201 ctgcagattc cagagcgagg accctgggct ctctcctacc ttcccagtaacccatgtgtg

43261 gctttggaca agtgcctctg cttcacaggg gccttggttt ccccaacgaggatgactcca

43321 aagagggagc atttgggggc tctgctagga atgtgtgtag aagtccacaactcattccct

43381 ttgcttaagc tggggtcaca aacctaacgc cctgaaggcc aggcaggtaacaatggtgag

43441 aaggtggggg ggcaccgagg gcacttgtgt gactcctcgg ttccagatagctgttgccat

43501 ggggaagacg ggcccagagt ttccacatct ttcgatattt caagaaacactggagatatg

43561 tatttatatg tgaaatctct aacctaatgt gaaatactct gaaaacactatgtgggcaga

43621 aacatacctg tggtctgcac cccctccagc tggcgcccgt ggtttgactttagggtgatg

43681 acgtgcacac cttcaaaggt gctgagccct gggagccttg tcagtccaacacgatgtagt

43741 gtgaacaagt taaccagctc gtctcggcag ttctgggagg agagaaagatgggaaccctg

43801 gggctccatg gtggggggca ccacagaatg ggcaggggag gctgtagccaggggtgcccc

43861 catcctgcca aagggacctg gggccaacac tggaccctgt ttgacaggcagacaagaggc

43921 cagcagaggg caaggctggg agcccgctca agggccgact ggtgacctcatggcggatgc

43981 ccggggaccg gcccacgctg ttcaatccgt tcctgctgtc tctgggggtcctcaggtggc

44041 gaagggtagg ctggctccag tggggactgg aggggtgagg gtggatagagacggggatgg

44101 gagggaggag ggggctgtta agcaaaggag agagagtggg ggctgaggaggaggcaccta

44161 gggccgtcgc atgacaggag aggtgggagc agagctctta agctcatcctggtctcagca

44221 agcgagtggg tttcccactt ccggggcagg cttgggggct gctttcagcttttggagtga

44281 ggggtgatgg aataatctac acagctgaaa gcttccaatc agcagcctctcgccagccct

44341 gggccaacgg ggagccaggt atgggggaag ggaaggcgag cttataagtggctctgggat

44401 tgcaaagtgt gtctcagacc tgggcctgag ccagtttcac aaacatctggcgttacgtaa

44461 cccatcccct gcccagagag gcctggaaac actcaagcct ctggctgggttttccacaag

44521 ggcaggcagc tgagacccgc tccctcccac ccgcttcaca gcaggacagaaggggcctgg

44581 ccatctccag cagccacagg ctggctcatg gggtctcttc tctctttgagaggctgactc

44641 tcttactcac cgctgttggc tctgagtcca gcactaggct gggcacctcagagacagtgt

44701 gcccatttta cagatgaagg gactgaggcc cagggaggtg agctgacttgcctgaggtcg

44761 cacagcttgg ggtataaagg agctgatttt cctcattctc agatgagagaagggttgtag

44821 ccaaacttac tgagcctcgg ttgccacatc tgtctattag gaaaaagtctgtggagactc

44881 agggctgcag agagggctca gggagatcag gatgcatgga ggttgcggggctgttgtcga

44941 aacactaact ttcccatcca cttcagaatt tccttttttt aaaaaattaagacggagtct

45001 cgctctatcg cccaggctgg agtgcagtgg caccatctct actcactgcaacctctgcct

45061 cccgggtcca agtgattctc ctgcctcagc ctccagagta gctggaattataggcgtgcg

45121 ccactgcacc cggctaattt tttgtatttt tagtacagac agggtttcaccatgttggcc

45181 aggctggtct tgaactcccg acctcaggta atccgcccac cttgacctccaaagtgctag

45241 gattattggt gtgagccacc acgccaggcg tttttttttt tttttttttaaattaagata

45301 gagtctcgtt ctacccccag actggagtgc agtggcacca tctcggctcactgcaacctc

45361 tgcctcccag gttcaagcga ttctgccatc tcagcctccc gagtatgtggtactacaggc

45421 gtgtgccacc acacctggct aatttttata tttttagtag agatggggtttcaccacgtt

45481 ggccaggctg gtttccaact cctgacttca agtgatccgc ccgccctggcctcccaaagt

45541 gctgggatta caggcgtgag tcacccagct gagcccagaa tttcctttcgctgctctttg

45601 tggttaaggc accgagggtg agcaggcaag catggttatc tgagtagtgtggtaccttta

45661 agccatgggc aggaattacc ttgtctaact aaaggtcacc aacacacagcacgtctggca

45721 ggagggggca ggtaagtcct tggtagagcg aaggaggagc gaagcagggaaagcactctg

45781 gggtaatgat gctggctaac cagcacttat tgtatgccta ctacatgcccagctctgtgt

45841 tcactgcatg gcgccaccta attgcatttg atccacactc ccaggtgcagttagacgcct

45901 actgtccatt ttacagatga tgaagtgaag ctcagagagg gagggtcacttgctccaggt

45961 cacacaggga gcaaggggca gaactgagat tcagaccctg ctctggctgacctcagagcc

46021 cagtgcttcc aacacgcccc ctacaccact gccttcacat cctgatctctctgagccctc

46081 ctgcagctct gggagtcccc acagattttc cccattagaa agatgcggcaaccgaggctt

46141 ggtgaggttg gctacagtgg ttctctcatg tgggagtgag ggaaatgaagagctagggat

46201 ggaactgcca gcagggcctc ccagttacac agagcagatt taaacttctcttgggctgaa

46261 gcagtgaaat tagcccaagg ccaagagcca gaaagcctgg agtcgagttctggcttggca

46321 cctaacttgt gtgcccttct ctgagcctta ccttattatt ctcagtagagtaacggtttg

46381 agactggata acctcgaagt ttggtagctc tggtctttgc cagtttaataactcacccct

46441 gggtccctga ggctgtgctg tctctgacct gccaggatga gttgtggtttcttcattggt

46501 gcattcattc attcgagccg tgcttacgga ggatgtgctg tgggcttaggccctaggctg

46561 gtttccaaga tgtagacaaa aaacattcca gccctggcca ctggagcccagttaggtaag

46621 gacactgaca tgtaactgat gagaacagtg tggtcaccac tttagtggggaaaggtacag

46681 atgtagggag cactgggcca gcagttccta agtctgctgg ggacactttggcttcctttg

46741 gtctgagact tcaaggaaga aattttccag gccaacaagc attgggagggggaaggggag

46801 aaagagagag agaatgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtgtgtgtgtgct

46861 gggtgtgtgt gagtgtgtgc tgggtgtgtg tgtgtgtgtg tgctggggtacagaagacag

46921 gaagagaagt gttccaggca cagcagagaa ccatcagggg gtagaaggacctgtcttatc

46981 ctgggaattc ctagtagtcc agtgctgtgt atcttttttt ttttttttttttctgagatg

47041 gagtctcgct ctgttgccta ggctggagtg gaatgcagtg gtgtgatcttcactcaccgc

47101 aacctacgcc tcccaggttc cagcgattct cctgcctcag cctcccaagtagctgggatc

47161 acagccatgt gccaccacgc ccggctaatt ttttgtattt ttaccagagacggggtttca

47221 ccatgttggc cagcctagtc tcgaactcct gacctcaggt gatccacccgcctcggcctc

47281 ctaaagtgct gagattacag gcataaacca ccgcgcccag cctccagtgctgtgcatctc

47341 tttatttact tattgtattt tgcaaaattg accaaagtat gtgtctctccagcctgtcaa

47401 atgagaatct ggaaggccag gatgacaggc aggagccagg ttgtgatggttcctgactgc

47461 ctagaagagg aatgtagcac tgatctgtca gcattggtga tgtgtggaagaactttgagc

47521 agggaagtgg tctggtcact gtgttgcggg tactaggagg agtcgcaggggccagaaaag

47581 cctggaggag gctggtgctg ttaggtgccc agggcactgg accaggaccctggtggtagg

47641 tgaggtctcc tgcgtgttca ttcactctcc caaggactga ctgcctgagtgaggtgcaag

47701 ggtagggtga gaaaactcag cccggggtgc cagaaggcca gtttctagagttagatggac

47761 ttaaccttgg cctcattcct catggtggag agactcctgg cagcaaatgctgggaaagaa

47821 cttcagctcc ctgggcctcc atttctttat ctgcaaaatg ggaacagtaattataaaagc

47881 aataattttt ttttttgaga gggagtctcg ctccgtctcc caaggtggagtgcagtggca

47941 caatctctgc tcactgtaac ctctgcctcc cgggttcaag cgattctcctgcctcagcct

48001 tttacatagc tggattacag gcgcctgaca ccacgcccgg ctaatttttgtatttttagt

48061 agagacgggg tttcaccatg ttggccagtc tgctcttgaa ctcctgatctcaatgatcca

48121 cccacctcag cctcccaaag tgttgggatt acagacctga accaccgcgcccggcaaggg

48181 caataatttt tgaaccccaa atcaagatga cagaataatt gaaatgccaattattccaag

48241 cttccctgcc tccttgccta aggatagcta atgagggata aagaggttgtcctaggtgcc

48301 ttacttgaat taacacttaa tccttccagc aacctcatga ggtaacagcattaccccatt

48361 ttacagagag tgaaattgag caccgagagg tgccttgctt aaggtaacactaggctggaa

48421 tccccgtgcc acacgaactt cctagtgcat ttagcaacca attccaccacggtccctact

48481 cacctgcagg aaaagagcat ctaacaaacg gcccagcgtt ctgggaacctgagcaacggg

48541 tgcacgccca cacctgaaaa accccaaacc aaaaaagacc catttgtgaggagtgggcat

48601 ttgggagaga ccctgccatc caagaactca ctttgtgtcc agcttactcgctaggaattc

48661 cgcctcttcc tgtgtgacct cgggcaaatc ggctcacccc tctgagcctccgttttctca

48721 ttagcaaaat aagacctccc tcccaagtct gtggtgagga cgaaaatcgactcttggcga

48781 gtgggacccg ctgagtcgtt agtactgggt gctttgcccc ggtccccgccaaatcacggc

48841 gccgagccct agcggaccca tcgctccggg gccgggtcgg gaagcgcagcctgggcgagt

48901 cgtgcccacg cccggccgcc cgcatcctcc gcccccgcgc cattgccggagtcacctgca

48961 ccctgggccc ttccttcctc ccagcgcgcc cgcggcccgg gcccgcccgccctccggccg

49021 ccaccgccct cccttccctg cggccccatc cgcccacccc gccgtcccgccgtcccgccg

49081 ccccgccgcc ctagcgcgcc cgtcccgttg cggcaggtcc cgcccccggcccgtctcgcg

49141 cttccattgg cccgccgcgg cccccgccgc tgtttgtctc ggcttccccgccacccattg

49201 gcccgctcgg gtcctcccag gaagtttgaa aaaaaaaaaa aaaaagttttatgggcggat

49261 ggaaggggcc ggggcagcgt cggggaaagg aagggccgga ggcgcggcggcgggcggccg

49321 agaggggcgg cggcggcggc ggcggcgggg ttcccgcgcc gcggagcccggcccgagagc

49381 cgcgtccacg ttcctgcctc ctgctcccgc cgccctgggg cgccgccatgacggtgagtg

49441 ccccagtcag ccgcccgcgc ccgaggccgg gagaagggcg acgacccgaggcagagccca

49501 gcctctcccc tccggggcag ccccctcctc atttcccgaa ggcgagaggagggctgggcc

49561 ggaagacggg gccacctccg aagcgctttc ggccagaccg gcctcacccttcccgcaggc

49621 tcctcctcgc cttccctcgc ccactcgccc ccgggagccc aggcgaccctgaggggacgg

49681 aacgacccgt ctcgggcgcc ccctcctcac acttgcggca ccagtcacgggtggattcgg

49741 ggcgaccctt tcccacctcc cctccagccc cctagacgaa gacccgattccccaaggcgg

49801 ccaggggccc cagggaggag cggaggtggg cctgggctgg ggaggggcgctcgtgggtgc

49861 ggatgggtcg cgctgacccg ggcctgggca agccagccct ccgtgtggccgctggcccga

49921 ggtcgggtgg gcgagaagtg gccggaccgc cccacccaca gcccgggaggcagtcccggg

49981 acgtctgaag cagcgggata ccacgtcttc ctgggcttgc actttgcagcggtcctgggg

50041 ccttgggaca agcctgcgag tctgagtagg gggcatgatg gcaggggtttgcctttctca

50101 tgggggtgag ctgtacccaa gccccatcaa ttacctgtgc catagttagcatattgagcc

50161 tcacagctgg gttcgctgga ctccccactt cacagccaga taaactgaggcttggggagg

50221 ggcgctggtg agttgcccga ggtcacccca agtataagag aaggagtagctcctttccct

50281 gtccttctgg cccactgacc gtgatgttcg ggaagggagg ggtggggctgcttttggttt

50341 ctggctagtg cttcagggag gctctgacag cccagtggcc ctcctgggggaggatgagca

50401 gggtgtgtgt gtgcacaggc ggcagtaggc ctctttcagg ggagtggagaccctgcggag

50461 gagtgggtgg gctgctgggg gcgggctggg ctgctggggg gcgtggcacgcctagcccct

50521 gccctgtgag tgtgatggcc tggacttcct cggcgtcctc ctggacatcctgccacctcc

50581 ctgctggccc ttcctgtcgt cagcagcctc cccttttctg tcaggagcagaagggatgtg

50641 gggggaggag ctgagtcagt gtcctggggc caggaggaga gaagttgccttgcccaccgg

50701 gtgcctgccc ggccctcagc cgggtgcttt cacgttacca gatttgatccttgaaggttg

50761 gtagtaacat cttaatcaaa cagatgagga aaccaaggtg tggcgaggtgaagtgtcatg

50821 ccccaggtaa ctcagtgagt cccaggctaa gccagaattt gtatccaggtccgttccagc

50881 tttctttcac agttgcctgt cctgggggca gcacgtgctg agcaagggtaaggctgccgg

50941 aagcagcgtg tggggtgctt ggaagatgga cagcacatcc ctgctggtggcagcagcctt

51001 cctgagggag gtgtcctcct gtgattatag ggccttgtca ggtggagatggactagcgag

51061 gagacagcag tgtggacaga aacgggtggt catgtttgag aagtagcaagagcgtaggga

51121 aggggtctgg ggaggagggc ctcactgcta gggcttggac aggggcaatagagagccatg

51181 aaagctttta gagcagagag gaggctatga tcaccattaa tagtgttcattgagttcatc

51241 ctggctgcca tgcagacctc agcctgctct cagctggtgc tcctcctgtacccacctcac

51301 accctcctcc cctggccccc gtgccctgaa tcagggatcc atacagagcaagtggcacag

51361 gtgtgtgagt gtgtgaggct ccggggcttc agggagttgg gattctcttccacccctttt

51421 gcctttgcct gggtgcagct ttgctcccgg atcagccttc cccctcgcctgctgggcatc

51481 aaattatatt tggtcccttg tttactgtct ctttcctaca gtccaccagggcaggggcca

51541 cagctcttgg tcacagctaa tttcctggcc tagaacagtg cctgataactttaaaaaaaa

51601 attttttttt ctgcaaacac tccctgagcc cctatctgtg ctgggtcctggcaggtaaac

51661 agtgtatgtc cctgactgtg agttgcatct aatctagcct gtgaaggataagtaaagggc

51721 ctcaagatag tcacggatgc aacagaggcc tctgagaggg gccatgggagggcaggacgg

51781 gggcggctgg tggtgcggtg agtggcatga actgtgaagg gacctcagaggtggccatta

51841 agctgggtct taaggcctga gtagccgctt gcctagtcat cggaggaggaggaagcatag

51901 tgtttcaggc caaggacatg gcacatatga agggcccgga gtcctggtgtgttgtgatcg

51961 gcaaggaata tgcagtggta taaacagggg cccctcagca aggggaggccaggctggaag

52021 agtgtgatga ggcttccctg ccatcctgag gcagctggac tttgttttaaagccacctgg

52081 agaccgggtg tagtggctta tgtgtgcctg taatcccagc attttgggaggctgaggtgg

52141 atggatcact tgaggtcagg agttcgagac cagcctggcc agcatggtgaaatcccatct

52201 ctactaaaaa taaaaaaatt tgctggacat ggtggtgggt gcttgtaatctcaggtattt

52261 gggaggctga ggcaggagaa acgcttcaac ccgggaggtg gaggttgcagtaagccgaga

52321 tggcgccatt gcactccagc ctgggcagca gagactctgt ctcaaaaataaagcaagcca

52381 cctggagccg tccctggaac tgttaagcaa gcctgggata ccaagcctttttgagtgagt

52441 cccgccagcc cgagggtgtg tagaggggtt gtgtgcctgg ccaggtaggaggcggggctg

52501 tgagaacctg ccagtactcc cgaaaggcgg aaggagaaac tgagcttctagcaggtgaag

52561 aagaggtagc tgggcctgaa gagccctgta tgaaggggca tcgtgggagatttagatgat

52621 cggacctttt gaccctgggg acaggtttcc ctgccagttt aaaaactcacattggttggc

52681 cgggcacatt ggctcacacc tataatccca gcatttttgg aggccgaggtgagcggatca

52741 cttgagctca ggagtttgaa accaacctgg gaaacatagg gagaccccatctctacaaaa

52801 aaaaaaaaaa aaaaaaaatt agctgagcat ggtggagtgc ttatgtcgtcccggctactt

52861 ggaagctgag gtggaaggat cgcttgagcc caggaggttg agtcagcagtaagctgtgat

52921 cacaccacca cactccagtc tgggcagcag agcagggccc tgtctcaacaaaacaaaact

52981 caaattggtg accttctatc cccaaggtca ctgtgtcatg gcgtgcctgacatggtatgt

53041 gatgtgtctg tactgggctc tggaggatca ctaggtttct ccttgtacagacacgttcag

53101 tcctgtcgga agctgcggga ggggaggacc gccccgtcat ttgccacatcaggcagccag

53161 gactcagaga ggggatgtga cttaggaagg tcacagtgac tccacttcccaggcagccct

53221 agaggttcca gcctgacagc ttgtcattcc tgccccaatc tcccagccctggcccaggga

53281 ctttcgcctg ggactgccca gtggtgccag ctctgtgggc ccaggaagcctggctcctcc

53341 gggctaggtg ggggtagggg agatggccca aaaagcacag aaatttagaccagggggtag

53401 atatttcctc agcaagtttt tcctgagcct tgctgtggtc aagccccctgcaaggccctg

53461 gggccacagg aggtcccaga ctgaggggaa gtggagccag gtgtggtcaccaatcttcat

53521 tcttagcttg ggatcgccct gggcagcctc cgtctcaggt ggaagacggggtgggcagaa

53581 tacagagcag cgggacaaac gcagccccag gggttctcgg ccgtgagcagagcctgtgtc

53641 tctcccttag acaggtatac agggaggggc tgggatgcca acctactgggtcccccgact

53701 gtggctgtgg aaggttctgg atcttcagct gtcccaagcc ccggttggtccacttcctat

53761 acctgagaag gggctccgtg ggtggagagt gggtcgggag aggtggccaggcagggtggc

53821 tgtggtttcc agctgccact gtcaccgccc actccactga gccatgccacccgttctctg

53881 caggcaacca gacaccttgg cctggtgagg cctcgatgta ggggctgataggtaggctca

53941 gagccatggc aaccggtggc cacctcctcc ctgccggcgc caggagcggagactgcagag

54001 ggaccgggac ttagatgaga gaggtctccc cagcaggaag ggagggtctggtggttggca

54061 cccactagat gagcatggtc agaaaaatat caggatgagc aacttctttatctaggcctg

54121 ggtgggggtg cctggcacag gtctccatgg gacatgctgc agctggtagcccccagaccc

54181 cggggctgtg cccccctggg cggcacccag aaggtagggc ttgccaggactgacccttcc

54241 caaagagatc taggcgggga ccagagggtt tctgacccca gcctgtgactggctccacct

54301 cccatagtct cctggagccg aggaaaggac aggactggcg ggcccatgggagggtccgtg

54361 gggcacttgg tcctcgtcag agggaggaac tggacagttc gcgcagtgctgctggtctgg

54421 actgccctct gagctctcag ggggtctcta tgcaggcaga gtcctcccagcccctctctc

54481 ccattcttgg gcgaggggtc ggctggagag aggcccctgg gacatctgggtgtgtgtgcc

54541 agccacccag cccaacttct tggctctctg agtgccacta tcaggaaaggggccagggct

54601 gcctcagtgg ctgggaggcc tgcttggact tgggggttac ctagggccttagccctcttg

54661 gctggcttcc caggagctcg gtcccacagg acttggggac agggtgggtgcagcacgctc

54721 ccctcaccag cccccattgg cttcctgctg gacccaactc acctccctcctcatctcccc

54781 acagcccgat ctgctcaact tcaagaaggg atggatgtcg atcttggacgagcctggaga

54841 ggtaagagga ctgaggccgg aggggaggaa gctggcttgt gctgctgctgggcccctggg

54901 cagcccagga gtgggggtgg ggctggggct ggtgtgagaa ccctgggggtggggctggga

54961 ggggtggagg ctgcccatta ggcttctgcc tcctggagca gtctgcagtgtgtaaaaggg

55021 atcacagcaa ggggccgtct agcccctcac acccagtgcc ccatcccttgatctcatcaa

55081 gagtctcttg gccctgccac ctcagtagga gcctgggtgg gagtcaagggtcttgggtgg

55141 aagggctcgt agaagctgtc tggcccgaga cacagattcc taaagcctggtctgaggggg

55201 gtggggctca gggcgcaggt gctggggttt cacccacctg gatccccactggttgagtca

55261 aagcctcctc tagtcctcag tggccacgtc tgtgacatgg gcataatggataatggtgat

55321 tctttctaga gtggataaca aggtcagaga gatcaagcac gtacaggtgccacaaagctc

55381 ctggcactta ctgtgggctc agctaaagac ccttcccttc ctctggcatatgtgtccttg

55441 gaaccagcag ggacagtggc tgtttcctca gctctgttct ttcggctgccaggctggctc

55501 cctgcccaca ctgcctgggc aggagcgtct ccccacccct gccctgcatgcgcctgctgc

55561 tctggtctgc gtgcagcctg catgccggag agggctttga gccagaggggatttcattgt

55621 gtttccggcc cacatgtttt attccctcca gcccacagcc ttccctacccgctgcctgcc

55681 cgctgtccct ggtggctgct ctctaggctc acacaaagcc cggcaccccgccagtgaccc

55741 cttcctggcc tccccaccca gggtccccgg agggcagagg gattacaggccccacccaga

55801 gctggccatt agtcatcctc tatcacaggg ttctggaatg tccgaactggaagggccctg

55861 ggaattcagc cagcccaacc ccttggtgca cagacaggag acgggcccatgagggtgttg

55921 gtctcttcca ggcctaggag cacctggggc agacccaggc tcagaactcagcgcacctga

55981 ggcccatgga gctccaccca gcttccatct cagacagtca taggctaggcctggaagagc

56041 taaagaaacc tcttggcata gaacccctgt cctactttac agagaggcaattgaggtctg

56101 cagcagcaac tccgtttact tagtgagagg aaaatgcttc taagaggcctggcctcccag

56161 aacaaaccca gcaacctggt tggtgtccat ccctatgcca agggccatgacagccatcca

56221 cacaagagag gatgggcgcc gctcgcctca ccagaaggtc taggcacttctttttttgtt

56281 ttttattttt gttttttttt ttctgaggca gagtttcact cttgttgcccaggctggagt

56341 gcagtggcgc aacctcggct cactgtgtct tccgcctccc gggttcaagcgattctcctg

56401 cctcagcctc ccgagtagcc gggattacag gcatgcgcca ccatgcccatctaatttttt

56461 tttgtatttt tagtagagac agggtttctc catgttggtc aggctggtctcgaactcctg

56521 acctcagatg atccaccctt ctcagcctcc caaagtgctg ggattataggcgcgagctac

56581 cgcgcccagc tatagggact tcttagtagc cctactttat ggttcagaagactgaagctc

56641 agaaaagtgg agacacttgc ctaaaggcac acagagagaa agggaactcttggatacaaa

56701 actccttttc tcagggaggc aatgtggaaa gaagcagaag gtatcgtcgttgcatgcccc

56761 ttgagaactt accatcttct tgaggagaga aaactaagta cttgaaacaaccaacagcac

56821 agacagggct tggtgatgtg agggaaccct gggagggctg gggaccgggtgatatgcact

56881 gaccctggca gtgggcgggc cgcgactggc attccagtgg agtgaccagaagcccagagg

56941 tgggctgggc ttggcatact atcaggctgt tctggcgccc ccacccctttcctacatgtc

57001 ctgccaatct aaccccagct ggagcagaga caggcactgc aggaaggcacccaatcacaa

57061 atcctaaact tacagcttag ggcgctctca cctgctgcgg atgtgggtagccagcctaca

57121 gttcaagaag cagaccgtgc atctgggcgc ggtggctcac gcctgtaatcccagcacttt

57181 gggaggccaa ggcaggtgaa tcacctgagg ccaggagttt gagaccagcctggctgacat

57241 gatgaaaccc tatctctact aaaaatacaa gaaattagct gagcatgatggcgggcgcct

57301 gtaatcccag ctactcggga ggctaagaca ggagaatcac ttgaactcaggaggaggggg

57361 aggttgcagt gagtggagat tgcaccattg cactccagcc tgggcaacaagagcaaaact

57421 cctccatctc aaaaaaaaaa aaaaaaaaag gcagcagatt gtggctggcactcactccta

57481 ctccagggct ccatccagtc ctacttccca ggggaccatt gtccctgaccatggtgatga

57541 tctgggggaa tatggaaaaa gacgtaacgt cctggccccg ctgagtccctgacttgctta

57601 cacaggtcat cacccctccc tgtctgcact gggtccgggg tgcctgaggagccttggcaa

57661 tcttaaaagg agctccaaga aggaaaggga gggtgtggtt acggaggggaaaccaatcca

57721 tttcacagat gctacccctg aggctcagag aggaaatgga ggggccaggtctcaaattgg

57781 cattttccgc ctccccaccc ctcctgtgtg cagcatagtg agtttggcagccacacagga

57841 cacctgtaca atcacacaca ctggctcttt cattccatcc tccttgcagcctccctcccc

57901 ctcgctcacc accacctcta cttcgcagtg gaagaaacat tggtttgtgctgacagattc

57961 aagtctcaaa tattacagag actccactgc tgaggaggtg aggccatgggtgtactgatg

58021 aacccccgga agggcctggg gtggcctggc tgggttcact ggggtgggtcacaccagggc

58081 ccacacggac catagtgggc cctcttgctc caggcagatg agctggatggtgagatcgac

58141 ctgcgttcct gcacggatgt cactgagtac gcggtgcagc gcaactatggcttccagatc

58201 cacgtgaggc tgtgtgcagc ttgggggctg gtggtgggca gcatggctggaggtccctgg

58261 gggaggtttt ggtgttgaac atggctcacc atggagactg gatcccttcactcatttacc

58321 cagaggccct atcttcagag ccagagctgt gatgccaaca cttagcatatctgggggaga

58381 cgctggagcc agcagggctc ttcccaggcc aatggaaggg aggttttgtaccccctgccc

58441 accccagact caagacctta gatgcatcct gggaaggaag ggccaccctccctggggtcc

58501 atagtgggga gggagtcatg cggctggcca tgtggcaacc tacccatgcggtggccttgc

58561 agaccaagga tgctgtctat accttgtcgg ccatgacctc aggcatccggcggaactgga

58621 tcgaggctct gagaaagacc gtacgtccaa cttcagcccc agatgtcaccaagtacgtac

58681 taagctggac tggggccttg agggaggcac ttacccttgc gtccccgagtgggtttctag

58741 gtactcacct gagggctgca cctttctggg ccctcgtttc tctgtcaacaacatgggaag

58801 agagtagtga gcattctcgg tatcatccag aagtacactg agggtttgaggtttgatctg

58861 tcttctcaaa tgtgatgggg cctcttctct ttggaggaga tgcctgtgagtcaaaagccc

58921 ctgccaggtg gctgttctgt ctctgtgtct gtgccgtggg ggccgtgtctaagcctgtgt

58981 taggaagggg tggttaggta gttcagcctt ggcgcccaca cctcccgggatggggagctc

59041 actccttctg gaggctgcca cgggcactgg ggcaggaggg ctgagttaccgagtggcaga

59101 gccccccaca gtttataccc agatgcccat ggcgggctgg gacttggagctgctgggcag

59161 cgggaacaga gtgtggtatt aaagggggct gggctgggtg tagtggctcacacctgtaat

59221 cccagcgatt tgggaggctg agatgggagg atcacttgag ctcaggagttcaagaccagc

59281 ctgggcaata tagtgagacc tcgtccctac aaaaaattta aaaatcagctggccgtggta

59341 gggtgcgcct gtcagctgag gtgggaggat cacctgagcc cggaggccgagtcccccaga

59401 ctggccacac cgcggctatt cagccttagg ccagaggctt tcctgtctaggtttcagagt

59461 ccccatctgt cacgttagca tgtcatgtct gtacatgtgc caggatgtgcccagagcact

59521 ttgtgaactc tgaagcactg tgcagttgga ctgttattta gcatctaggcccagctgctt

59581 taagaaagaa accccgggca cagtaacttc atcgagatag atgttcatgtctcccttcag

59641 aacagccccg aggtatgcag tcctggcctg gtggggctcg ctctgccgtttcaggggagc

59701 cacctgccac acccactcgg cagcctatag tcacatggct acaagtagctgtgggaatac

59761 tgcgagtgta gtttttggca gggtgaccac gtacccagct atgactgtggataaagagaa

59821 ttgccatagt tgttcagagt ctctgcaact tgtgttctgt gcaccccgaggtcccgcctt

59881 caccccatca gcagtgactg ggcatccccc ttgccactgt gagcctcgggaacctgggac

59941 attggtctcc tacatcacct cattgatcac catttgcaaa aagccccctgcctgctttcc

60001 acgttcgccc accctgtcct cacatccatc ctgtgagagg cgtcgctgtcccacattaca

60061 gatgaggtca ctgaagctca aagagggcaa agagaccagt gtggtggttcacgcctgtaa

60121 tcccagagct ttgggaggct gaggtgggag gagcacgtga gcccaggagttcgagaccaa

60181 cctgggcaat atattgagac cccatctcta tcaaaaattt aaaaaattagctgggcgtgg

60241 tggtgcatgt ctgtagtccc agctactcca gaggccgagg caggaggatcacttgagcta

60301 aggagtttaa ggctgcagtg aactatgatc acaccactct acttcagcctgggcagcaga

60361 gtgagaccct gtcccttgaa aaacaaaaac aagaacgggg gcgagggaagccgggcatcc

60421 tggtgggtcc ctgggctgtc aagaggtgga gctgggatgt tcctggggtctgttaaccag

60481 gaagctcagg tcgggctgct tccttccctg gggtctgtct ccagcccctggcacagggcc

60541 tggcacacag gtgtcgctcc aaaagtgctc attgtgggac tgcaggggtgaggacccacc

60601 tgacgtggct ctgctggtgc cctaggctct cggactctaa caaggagaacgcgctgcaca

60661 gctacagcac ccagaagggc cccctgaagg caggggagca gcgggcgggctctgaggtca

60721 tcagccgggg tggccctcgg aaggcggacg ggcagcgtca ggccttggactacgtggagc

60781 tctcgccgct gacccaggct tccccgcagc gggcccgcac cccagcccgcactcctgacc

60841 gcctggccaa gcaggaggag ctggagcggg acctggccca gcgctccgaggagcggcgca

60901 agtggtttga ggccacagac agcaggaccc cagaggtgcc tgctggtgaggggccgcgcc

60961 ggggcctggg tgcccccctg actgaggacc agcaaaaccg gcttagtgaggagatcgaga

61021 agaagtggca ggagctggag aagctgcccc tgcgggagaa taagcgggtgcccctcactg

61081 ccctgctcaa ccaaagccgc ggagagcgcc gagggccccc aagtgacggccacgaggcac

61141 tggagaagga ggtaggcacc acggctggct ctctaggagg ccccttgccccagcgcccct

61201 ccagtccctg cattcatgcc ctggcatttg tcttgcactc ctacagtgatggggagctca

61261 cccctgatct gctgtgagtg tgcaccccac actcctgcga actagaatcttcttccttag

61321 accttagtag tttggtttgg ttttgttttg ttttttccta gttctgcccttagcagccat

61381 agagaagaga agtgggaaga gaagggagag acctgccagg ctcacacctgtaatcctaac

61441 attttgggag gccaaggtgg gagggtccct tgaagccaag agtttgagaccagtctgtgc

61501 gacatggcaa aaccccatgt ctacaaaaaa atacaaaatt tagctgggcgtgctggtgca

61561 tacctggagc cccagctact tgagaggctg aggtgggagg atggctggagcccgggaggc

61621 agaggatgca gtgagccaag atcaagccac tgcactccag cagtctggcaatagagcccg

61681 actttgtctc agattaaaaa aaaaaaagaa gaagaagaag ggcgagaccgtttattgttc

61741 atcttctgcc cgtggcctcc ctgcctgcac tgactcgtgg aatcctcacagcggcctcta

61801 cccctagggt ggacttcagc agttttactg acgggaaaac tgaggctcaaagatgtttcc

61861 tctgtcacct ccatgatgtg taaacatctg tgaccacagt ttccttttcctatccctgtc

61921 tagccttctc tgggccaagg ctctcccagg tcattgacct ggccatccaggaaacagccc

61981 agcgtgtccc ctggctacat ctcactccag ggctgcttgc ccttctcaaaccctgaggca

62041 ttcctaagcc ttccagggac gctgggcttg tatccgtgtg gagctggaagcctgcgggct

62101 cctcactgcc ttccaccagc cctgccccag cttccaggtc ccactgaccacccttctccc

62161 tcgtaggttc aggctcttcg ggcccagctg gaggcgtggc gtctccaaggggaggctcct

62221 cagagtgcac tgagatccca ggaggatggc cacatccccc cgggctacatctcacaggta

62281 aggccggggg gctgtttttc agggggaggg ggcagatttc tgcttgccgtgttatcagga

62341 aacagctgag attttgggag cccttcctgt gtgtgctgga acctgtgtggggcatttgac

62401 atgcgtcatc tcatttactc tccccacagc tggtgggcgt gatcactgtgcccgttttac

62461 agacaaggcc actgagctct gagaggttat gtgacttgcc caaggtcaccccgcctgcag

62521 gtctcaaagg tgggatttga gcgagggtcc ggctgactgc agagcctgtgtgtgagtccc

62581 cgtgtgacac tctgcacttg gacccttgcc ccggggaagt ggggggctagtggccccgag

62641 agtcactccc tgaacacagg gaaatcctgc cgaggcccac tgggccaaggccccacacaa

62701 ggaggtctgc aggacagggg agcctccagt agccctcaga gaatgcaccgtccgcctagg

62761 acagcggttc tcaacggggt ccattttgtc ccccttgggg acatttggctgtgtctggga

62821 atacttctgg ttgtcacaac taggacaaac taactctcta gaaaaaacgtgtgtgtgtac

62881 acatatataa gtttattata aattttacca ataaaaacaa tgcttagtacacaatttaca

62941 aataaaaata tataatttta ttgtgaattc cgtacagcaa atggatttttctcagaatgc

63001 tttcagtgat tttttccata ctcttgtatc cacaactgat taacaaagggggttgttcta

63061 acgtgtgctg gttgacattt ttgtttatgg taatgagtaa gatgagaagacatttgtcga

63121 aactttactg gtccatgttg tcagctactt ctttgctaga tcggatagtagttttctatt

63181 gagaatattt gagaatattc tattaagaat atttttgcaa ttttttgttctatttacaat

63241 gtaatggtta tagatgtgag atacttctaa gtttaatctg cattattagcattttcttat

63301 cacttgctta agtctagaca atcaacaaaa caataaatca agccctgatgtgtaatgttt

63361 accaattctg cagtgtaaat actcccgctg tggccaatgc tgcattaccagcacaaagtc

63421 cctggacaga gagttgggaa gagatgtcac actattcact aggatttccaccatgcggat

63481 acagtagatg tgattggccc caagagcacg cataatacaa cacagtgaaatatttaggaa

63541 gtaataaatt tgagtatcta ttgccttgtc tttaacatag ttaatttaaagtatataaat

63601 ttaattgtta atggctgtgc ttaacaacta catcacagaa ttactaaaaatttgacaatc

63661 agctgtctgt agttatcaca ccattatcta aagtagaaaa gaaggggccaggcgcagtgg

63721 ctcacgcctg taatcccagc actttgggga ggccgaagtg ggcagatcacgaggtcagga

63781 gaacgagact aacctggcca acatggtgaa actccgtctc taataaaatacaaaaaatag

63841 ccgggcgtgg tggtgcgcac tgtagtccca gctacttggg aggctgaggcaggggaccca

63901 ctggaaccca ggaggcgcag gttgcagtga gccgagattg cgccacggcactccagcctg

63961 gcgacagagt aagactccat ctcaaaaaaa aaaaaaaaga aagaaaagaaaagaaggctg

64021 agatctaggc cctaggcagg aggagccttc taaaaatttc caaggggaggtcacgtcatg

64081 agggggctct caggaaggca ttggctgggg catgagaagg aaggctggttggtgcgtatt

64141 gtggatgcct ccagtgctga gctaatagtt agaagctctg gcctggtacggtggctaatg

64201 cctgtatctc agcactttgg gaggtgaggt gggtggatca cttgaggtcaaatgttcgag

64261 gccagtgtgg ccagagtggt gaaaccctgt ctctactaaa aaaaaaaaatacaaaactta

64321 gcagggcatg gtggtgggcg cctataatcc cagctactcc agtggctgaggcaggagaat

64381 cgcttgaacc cgggaggcag aggttgcagt gagctgagat cctgccactgcagcctgggt

64441 gacagtgaga ctctatctaa aaacagcaac aaaaaacaaa acaaacaaaaaaagagaagc

64501 tcattccaca gacttttgga ggtttggggt cagacagtga catcaggaaagtgatgttgg

64561 agtggagggg gcttgggaga gggccaggtg taaggcatta ggaaatggctgaaggagggt

64621 gaatgtcaag ggtctggagg gaggagaatt tgggactgga tgaccagatctacggaaggc

64681 agaggggcct ttgggggccc tgaggctggg gctgctgctc cagggaagcccggagaccgt

64741 cctggggcca agtagtggat ggagtttcca ctgatagagg agcaggcaggggaattgggg

64801 tgggacgcag agggtgaggc tgggggctta ccttgtcctg gggaggggcaggggaggagc

64861 cagtgttgtg ccctgtagcc tcccaccctg aggcagagaa gggagctgggggcccaacac

64921 cccagctgag gcaggtggga gggcctccga ggcccccagc cagggggcttctgcctgcgt

64981 gctctgctct aagaagctgc aggggctgct ttctgggtgg gtggggctgggacccattcg

65041 tacccaccta taatcagagt ggcttcatct tcctccattt tattttattttaattttttt

65101 agagatgagg tcttttactg tcacccaggc tacagtgcag tggcacagaggctcactgca

65161 gcctcgaact ctagggctca agcagtcttc ccacctcagc ctcctgagtaggaaccacag

65221 gctacaccac catgcctggc taattaaaaa aatttttttg tagagacaaggtctcactat

65281 gttccctggg ctggtcttga actcctgggc tcaagtgctt ctctcatgttggcctcccaa

65341 agtgctgggg gtacaagtgt gaccactgca ctggcccacc tttgtccgttttactcatag

65401 agccagcttt agatttcctt tagataaagg ctctgccact acaatgacgtttaaaaggca

65461 ctgctttggc ttctcagctt actggtggca aaactgaggc ccacagaagggtgtgacctt

65521 tgagctatag gcagacctgt gtctggagtt caggcggtct ggtccccaggtgccccattg

65581 ggtgcaccaa agtctgtcag tgtttggtcc cgttagggtg ggatgggcacggggagcagg

65641 tgggagggga gaagggaata actggggagc agagctgaag accaggcaggtggaggagtg

65701 accccagatg cggaaggcag cagagaagaa gagctgagtc atctgtatcgccctcaggca

65761 cgggaggagg cggatggaaa ttcggtggac ctggaggagt gacagctgggagggattccc

65821 cagctggtat ctcgggctga gtgggtgccc ttccttcagg ggttgggggcttgctgctgc

65881 acgacagctg tcgggtggtc tggggcttca cccactggac atctggtaaagagaaccttt

65941 ccccactatt gcagtgggga cagaggcatt tctttatcta ctttgatgtccatgtcaaag

66001 gtggcagcca ggatcaggac accttgggcc actcaggaag gtaggtgagagaggccctag

66061 gagcccctgt tcgtcagctg agtcccacct cctgatgtca gcccctgcacccctgagctg

66121 ctgggtctgc ctgcctggtc tggccctctt cagaagagca gtgcccacccccacattgct

66181 gggctcccca ctggtggatg ctggcgtacc gtctccctct gtgcacagggttcccgtgcc

66241 cagggagcct cgggggctgg tcctgtgagg cctgctttac ggatgccaagactgaagctc

66301 agagggggcg aggggtttgt tcaggttcac tccaaggcgc agccagggtgaagaccgcct

66361 ctgaggtcca aagtcatgtt ctgttgtcct aagccaggag acacatagagggcaggaaca

66421 gaagccaggg gacagacacc cctgtcgcca catgaagctc ttggccctcgctcctccatc

66481 aaatcgtccc caggtgtggc tgctggagag gcggggaggt ggcctttgcgtgggggagac

66541 agtccctcat ctggtcctct gtgccttagt ttcttccctg gctcttcttccccttccctt

66601 tttaatgacc ttaaacattt ttttaattat ataaaagaaa tgtttacattttcaaaaata

66661 atttaaacaa attgaaaggc tggaaatcaa caccctcaca ctccttctgctgccagctgc

66721 caccccaggg tcctgtcggt ggctgctgcc gcctgcctat cagtttctggtggcagctgt

66781 aacctgtaac cacagctacc taaataatgc acatgtatta cctcacgcttctgtaggcga

66841 gaagtctaac gcgagtcttg ccgcgctgca gccaaggcgt gggcaggactgtgttcctct

66901 gcaggcaccc gttgtatccc ttgcctgctc cagcttctgg tggccgtccgcgtcccttgg

66961 ctctcggccc cttccttcat cttcaaagcc tgcagagggg aagtcgagtccttctcctgc

67021 cacgtcactc tgaccatccc ttcctggtca cacctccctt gaactcttcgcttctgcccc

67081 cttcgtccac ttttaaggac ccttgtgatt acactgggct tgagggataatctgggataa

67141 tctcccgatt ttaaggtcag ctgattagca accttgattc cctctgcagcctgaattcct

67201 ctttgccatg taacatgatg tagtcacaga tcctgggagt aagatgtggacaactttgag

67261 gggctatcat tctgccccct acaatatcct ccctaccttt tctgtgttttctgtgttttc

67321 cattcactgg gacggacagg tctgcacgtt tgttcccgtg agtgagatcataccacgtgt

67381 atgtcagaag ccaactttca ccacctcatt ttgggatctt tttccacagcatccacacaa

67441 aaactctgtc tagcagctgc ctgtgtccca ttgtcaagct cgatcccatcatttattcaa

67501 gagttcccct gatagggatt tagattgttt ccagttttca tctgttaccaacctggctgt

67561 agggaatacc cttgttccaa aagtctctgt acacatacga ctttctgtgggatcatttct

67621 gggagtgaac ctactaggtc aaccagtggg gtcgcaaaat gtgatgatgccaccggacca

67681 cccccaacac acaccgttgt ggcggacact cccagcagtg ggtattattagtctgagata

67741 cttgcccatc ttgtctacta agcattattt tgtattacat catcagtttcagctcattta

67801 ctgagcacct gccacatgtc aggccctggc ctagaccctg gggactgcgccagtcagatg

67861 ttctcagtct tcagggaatt tatggtttgg cagaggtaga accttttgaggcaggggaga

67921 ggctgcccag agacagagct aggagagaca tttaaactgg gctgcaggtcagtaaattac

67981 ccagggaggt aaagttgcca aaaaaacatt ccaggccggg cacagtggctcatgcctgta

68041 atcccagcat tttgggaggc caaggccggc agatcacaag gtcagaagttcaagaccatc

68101 ctggctaaca cagtgaaacc ccatctctac taaaaataca aaaattagctgggcgtggtg

68161 gtgggcacct gtagtcccag ctactcacga ggctgaggca gaagaatcacttgaacccag

68221 aggtggaggt tgcagtgagc tgagattgct ccactgcact ccagcctgggtgacagaaca

68281 aaactctgtc tcaaaaacaa aaacaaaaac aaaaaaacca caaaattccaggcagtggga

68341 atagctaaag ctcagaggtg tgaacgtgct gcaaccgtaa ctgtgagattgcttggcaga

68401 gaaaggccag ggatgagaac gtaaaggtca gccatgggaa cggggacttgactctgtagg

68461 acgaggaatc cctggagggc ttgaggcagg agcgacaagg tgaggtttgtgaatgaggag

68521 ccgtggggtg ggggtgggag caggagcagg tgcagactgg aggtgctgggacccaggagg

68581 aggtggtgta cctgcccctg agccttctcc tctggaggct ggggaagggccgctgtccag

68641 aggaacgggg cagcctgtga caccctggcg tccggcccac aggaggcatgtgagcgcagc

68701 ctggcagaga tggagtcctc gcaccagcag gtgatggagg agctgcagcggcaccacgag

68761 cgggagctgc agcgcctgca gcaggagaag gagtggctcc tggctgaggagacggcagcc

68821 acggcctcag gtatggaccc tggggggggc acagtgggct gggctctgagcctctgtgct

68881 gaggttcctc ctagccaaac tggggaggat tttatcaaat aagatgtaggggtctcagtg

68941 ccacatttgg ggtaaagggt cagcaggtgt tagaagctcc aagaactggcctgtagccct

69001 acttaaaaag ggaaactgag gcagtaaaag ataccctccc cacccccaacaccaccacta

69061 ccataggtgg tgactcttcc tgctcagggg cctgcagcca ccatagagtctgcctaaagg

69121 cacatgctac ccacgtgcgt gggggagagg ctgatcagct gcatcccctgtcctcatagg

69181 agtgcctcct ccctgggcac atgggccaga ccctggggag agcaggggaaggtgtgagca

69241 ttgtccatgc cagctgtgtg ccaggcactg ggccccacat gtttcccacaggagcaccct

69301 tcatcctgga caattccctc ccctcctgcc accgcacacc tgctgtgtgcctggcacatt

69361 cctaggcatc actaggggtt tgcagaacaa tagaaatgct ggccaatgtcacatgatctg

69421 aagctcacaa cctgccagtg ctgtgccaag tgctcatgca ctcgaacccagccttggggc

69481 cagtgtgctc tgcatttcag gaagatcgcc tttgcagccg cgtgtgttagagaccccttc

69541 cccctcagca gagtctggac ttcgccctgt aatctggcac taaggtttctgctgtgaaat

69601 ggataaaaat cacacttaag tggaataata aagaccataa atagcctcatgtccgttcag

69661 ggtggggatt gccaccaaaa gatttaccag aggcccggtg cagtggctcatgcctgtaat

69721 cccagcactt tgggaggctg aggcgggcag atcacctgag gtcaggagttcgagactagc

69781 ctggccaaca tggtgaaacc ccatctctac taaaaataca aaaattagctgggcgtgatg

69841 gtgggcagct gcaatcccag ctactcagga ggctaaggca ggagaatctcttgaacccag

69901 gagacagagg ctgcagtgag ctgagattgc accactgcac tccagcctggatgacagagt

69961 aagactccat caaaaaaaaa aaaggccagg cactgtggct catgcctgtaatcccagcac

70021 tttgggaggc cgaggcaggt gcatcacgag gtcaggagtt caagaccagcctggccaaga

70081 tggtgaaacc ctgtctctac tatgaataca aaaattagcc atgcgcggtggcaggcgcgt

70141 gtaatcccag ctactcagga ggctgaggca ggagaatcgc ttgaaagtgggcggcaaagg

70201 ttgtagtgaa ccaagattgt gccactgcac tccagcctgg gtgacagagtgagactccgt

70261 ctcctgggtg acagagtgag actccgtctc ctgggtgaca gagtgagactctgtctcaaa

70321 aaaaaaaaga aagaaaaaaa ggagagaaac tttcaatgtt cagaagtttcggattttaga

70381 attgtgggta aaaccatggg tggccctgag tgggaaaaaa aaagcctcggtctcagtcct

70441 taggagctca caatctgaga ataaagccag caggagctaa tgttggggcatttactctga

70501 gccatgcttt gttctaaatt cttcacacac cttccaataa ccccatggaggaaaggtact

70561 gttgttatcg atccctgttt tccagataag ggatctgagg cacaaggggttaagtcacct

70621 gtgcaaagtc acatcggttt atgctgactg tggagcctga gctcttgaccacgaggctgg

70681 tcaaagcaga taggccttgt ttgagagccc tcagagtctg cagggggggtgtactaggtg

70741 gggtcctacc tggaaatcac tagaacagga ggtaccaatg gtcagaccctgagctgtctc

70801 cccagtaggg tccatccaac aggattatct tcccttaata gatgggctgagagaggttga

70861 gagcttaccc caagccactc agtttatgac acaacctggg ctactctagactcctggttc

70921 ggtgctcttt gcatagcact ccttggtcca agtccatagt acttgcatagtactatgtgg

70981 agtccacata gtactccacc agtacatgtg gcgtctcaga gctggtggcacttggtgctg

71041 ctgacccccc tccagtctct cttgtgcctc tctgccctgc ttccagccattgaagccatg

71101 aagaaggcct accaggaaga gctgagccga gagctgagca aaacacggagtctccagcag

71161 ggcccggatg gcctccggaa gcagcaccag taagatgatg ccggggcccaactgcccacc

71221 ctgatggtta tgggttgagg aactttgctg aggccccttg gcagcggacacatcagtttg

71281 cccctagctg agattcctgc tccagtctca tggatgcaag aaacagaagcagaaggtcct

71341 caggcagacc ccatgccagt cctcacagac agtccttcag gcagcttcttgtcttggctg

71401 gtcccagcct ccacccacct cttcacccct ttagtctccc ctggagctgggctgcagtgt

71461 cactgttgac cactaggcct ctccctgccc cagagcacag ttttggaatgttgaggtttc

71521 aggggcttta actttaaaga tgggcccctc cagccgggca cattggctcatgcctgtaat

71581 cccagcactt tgggaggctg ggatcaggag ttcgagacta gcctggccaacatggtgaaa

71641 ccccatctct actaaaaata caagctagct gaatgtggtg gcgggagcctgcaattctag

71701 ctacttggga ggctgaggca ggagaatcgc ttgaacccag gaggcagaggttgcagtgag

71761 ccaagattgt gccattgtat tccagcctgg gcaacaagag tgagagcaagactccatcta

71821 aaaaaaaaaa aaaagatggg ctcctccaag ccaccctcac ttagggtaaacacctgtagc

71881 ccagagaagc tgtcactggt tcacagcccc acagcaggct aaaggcaaacctagagaggg

71941 aaccccagag tcctgggatg ctttaagtct acctgactgg actccaggcttggcaggagc

72001 aagacaacct atgctctcct ctgctcctcc tctggggcag gtcagatgtggaggcactga

72061 agcgagagct gcaggtgcta tcggagcagt actcgcagaa gtgcctggagattggggcac

72121 tcatgcggca ggctgaggag cgcgagcaca cgctgcgccg ctgccagcaggagggccagg

72181 agctgctgcg ccacaaccag gtgggcctgg ccccaggttg gggggacacgggtgggtccc

72241 ggcacccctc ccctgaccac cgtgcctctc ccaggagctg catggccgcctgtcagagga

72301 gatagaccag ctgcgcggct tcattgcctc gcagggcatg ggcaatggctgcgggcgcag

72361 caacgagcgg agttcctgcg agctagaggt gagtgtcctc actagcaccaggcagcccag

72421 tggttctcgg ggcccggggc tatggggcac ccccgccata ggctgggtatcacctgtggc

72481 aggaaagcca agtctcccag tggctgggcc agcctgacta ggctagaacacctactgtgc

72541 atccagtagc cagcattctg ccctcccacc tgcattgtgt cacctacctgccgtgtacca

72601 tagcaaatca ctccactttt ctgagtccca gtagctcatc tgtaaaatggcaccagcacc

72661 ttccttactg ggaaatattg gggtaagaaa atatgtgtgt atgtgtgtgatgccagtatc

72721 actgtagtat tttctttctt tttctttctt tctttttttg agacagagtctctctctgtc

72781 acccaggctg gagtgtagtg acacgatctc agttcactgc aacctctgcctccctggttc

72841 aagcgattct cctgcctcag cctcccaagt agctaggatt acaggcctgcaccaccacac

72901 ccagctaatt ttttatattt ttggtagaga caagtttcac tatgttggccaggctggtct

72961 cgaactccgg acctcaagtg atctgcctac cttggcctca caaagtgctgggattacagc

73021 atgagccacc acacccggcc ttagtattta tttctttact ttttttttttttttgagaca

73081 gagttttgct gttgttgccc aggctacagt gcagtggcgc gatctcggctcaccacaacc

73141 tccgcctccc aggttaaaac gattctcctg gccgggcgcg gtggctcacgcctgtaatcc

73201 cagcactttg ggaggccgag gcgggcagat cacgaggtag gagatcaagaccatcctggc

73261 taacacagtg aaaccccgtc tctactaaaa atacaaaaaa attacccgggcgtggtggcg

73321 ggcgcggtgg cgggtgcctg tagtcccagc cactccggag gctgaggcaggagaatggca

73381 tgaacctggg aggcggagcg tgcagtgagc cgagatcgtg ccactgcactccagcctggg

73441 tgacagagcg agactccgtc tcaaaaaaaa aaaaaatatt aaaaaaaaaaagcgattatc

73501 ctgcctcagc ctcccaagta gctaggatta caggcatgtg ccacctcgcctggataattt

73561 tgtattttta gtagagacag ggtttttcca tgttggtcag gctcttctcgaactcccaac

73621 ctcaggtgat ccgcccactt cggcctctca aagtgttggg attacaggcgtgagccaccg

73681 tgcccagccg atattttatt tctctttttt tttttgagac ggagtcactctgtcacccag

73741 gctggagtgc agtggcacca tctcggctca ctgcaagctc cgcctctcgggttcatgcca

73801 ttctcctgcc tcagcctccc gagtagctgg gactacaggc acccgccaccacacctggct

73861 aattttttgt atttttagta gagacggggt ttcaccatgt tagccgggatggtcccaatc

73921 tcctgacctc gtgatccgcc cgcctctgcc tcccaaagtg ctgggattacaggcgtgagc

73981 caccgctcct ggccccaata ttttatttct tcaacaaaca cttaggtgaggctcactctg

74041 tacctagaaa ttctggaagc cctttttgtc tgttaactca tctaatcttcctgacagctc

74101 catacattag ctactatgac tgtccccatt tacagatgag gaaactgaggcacaggaagg

74161 tcaagtacct taccaaagct tttatagctg gactgggatt tgaaccaggcagtctggctc

74221 cagtctgagc ttttaagcct ccccagtcct ggctgaactt gtttcctccttggtcaagtc

74281 agcagcacct agccctcggg gttggggagg ggttaatgag gtgccttgtggagtggttca

74341 gcctgctcag gtttatgtag ggcttctttt catccatctc actcccgaggtgagagcctg

74401 gtgctgcatg agggctgcag cagacttgac cgtgagatat ccactcacacgggctggaca

74461 ggggtgagag taagggaagg caaagcaggg gaatcggaga gggcttcctggaggagtccg

74521 cctccaggat gtagagggtt tttgtgcaga taggggctgc attctaggggcctgaggcag

74581 agagaacccg ggctgcaggg cactatgggc cagggtagct ctggcttctggccctgggtc

74641 agtccagcac ctatatcccc aggtgctgct tcgcgtaaaa gaaaacgaactccagtacct

74701 aaagaaggag gtgcagtgcc tccgggacga gctccagatg atgcagaaggtaggtccttc

74761 cgctgggctg ggggccgtcg gggactctgg agccatctgg atgccatcctgtgagcacct

74821 gctctgtgcc aagccctcca ctcgcttcat ccttcctcag gctctcctgtgcttctccca

74881 tgtaggtgtc atcatcccca ttcactgaca gggaaactga gactaagaaaggggaagtga

74941 cttccccaag gctgtacttg gcttctgttt atttagcatt atttaatttattgattatta

75001 ttgagcacct actatatcct gggcactgtg ctaggtgctg ggaagacagatgtgaacaaa

75061 ataaccccaa atctctgctg tggggagctt gcactccagt gagaataaccacgttgctag

75121 gagttgggtg ggtcagggtt cagcccaggt ctgagtctgc agcccgcctggcccaccctt

75181 ggctgctatg tcactgcctg gtgcgctctg tcagtttggg gcaggaagtggacatgttgg

75241 tggctctgta agtgcacgtg agccagaccg tgtttaccgc acttgaagaacaggtggcgt

75301 gaactcacag gaagggcccg agcacccagc caggctgacc tggttctcatcccagccact

75361 cactgccctg cggtcttggt caaaatcttc tcccccgaaa caggatgaggatgacaatga

75421 cgcctgtgtc cctgggtggt accagggagg tgggaggggt aagcccagaacccacggcca

75481 tcttggggag ccacctggag ggatgaagcg aggtatctgc ggggaggtctggctgctggt

75541 gctgcccatg tgcccggttg gcagggctgg agggagagac ttcatgccctcatacctgcc

75601 tcctgccccc caggacaagc gcttcacctc gggaaagtac caggacgtctatgtggagct

75661 gagccacatc aagacacggt ctgagcggga gatcgagcag ctgaaggagcacctgcgtct

75721 tgccatggcc gccctccagg agaaggagtc gatgcgcaac agcctggctgagtagaggtg

75781 gatgccgagg cgtgtgccct gcagggtggg caggggctga ggctctcccacacccgggac

75841 tccctggacc accccagcca ggccacttcc ttcttctggc ctccaattcccgttctgtaa

75901 aaaggacaat gaaaccagca acacggggtt gttgcagaga tcccatcagacccgggccac

75961 aggctgcttc atcagcttaa gcctgttcct ccagagctgg gcggcacagtgcagagccac

76021 agcctactca gtgcaccccc cttcttgggg ctggaggcaa atgcagcgtgcacatccctg

76081 acccccacag tgaatctcca ctgagcttca cacacacaca tcgcacgctgaggccgggct

76141 tctatcccag ttagtcttaa cactccttct tgacttagca gggctcaaagtggttggttg

76201 gttggttggt tggttggttg gttggttggt tggttggttt tggttgctttgagaaaggtc

76261 ttactctgac acccaggctg gagtgcagtg gtgcaatcac ggctcactgcagcctcaacc

76321 tcctaggctc aagggatcct cccacctcag ccttctgagt agctgggaccacaggccctc

76381 accaccatgc ccagataatt tttgcacttt ttgtataggt ggggtttcgccgtgatttcc

76441 caggctggtc tcgaactcct gggctcaagc aatacacctg cctcagcctcccaaaattct

76501 gagattacag gtgtgagccg ctgcacctgg ccaaagtgtt cttatttttgctttttcaac

76561 gccacatcta cctggagcat cctctttctg ataagtcctc atggacttcctatggcatgc

76621 aggagaggcc accctatggc tgagctgctt gggaaggagc caggaagagcggatctggct

76681 gtaccttagg ggctgagagg tggtggaagg acccactcag cacccttgcttggccttggg

76741 gtggcctcgc agcccctcag cccaggcctc agccctgccg caccttgtctttcaggtccc

76801 gcccagctgc agaccctcca ggctggagga ccagccgccc tccttccctcctggatggaa

76861 gtaaaaagcc aagctttctc cccaccctct gtgggccaca cgtgcacttgcacccaccac

76921 acacacacac acacacacac acacacacac agacacacag acacatacgcacacacgtgc

76981 acacatgtac acacggatac acacacacac acacacactg catatctgagcgcgcccctc

77041 gcactgggtc tcaccttgca ccttcttcag gattttatat gtgaagagatttttatatag

77101 atttttttcc tttttttcca aaacacttta tactttaaaa aaaaaaaaaaaaagcaattc

77161 ctggtggctg tgtgcctcca accctggtcc ccctctgtct ccagccaccctctgcttggg

77221 cttctgagct ggtggccctg gcccagaggt ctggcggagg cccaggcagcagccatggcg

77281 gggtgtctct acaggggaga ggcgggagcc tgccaccctc ttcctgccctacctcctact

77341 aacacttcct gccccatttg gacccgtacc atggggctca ggacagagggagctagcagc

77401 tggcctccat ggccccacag cctccttcga ggctgtgctg ggtgcagaaccgccagagcc

77461 acccaaaagg tgtttctctt ctgctccctg aacctcttaa cttaataaaacgttccagca

77521 gctctggtgt cctagatggc tggcagaaca ggaatggaga ttggggtttcttgaagtggc

77581 ttccccactc acaccctacc cacaccccac ccttcctaaa gcagcggcctctaggcttct

77641 gagggtgggg ctgaaaatcc aaggtctccc ttagtacaga ctgtgacgcccccagtgtgg

77701 cttgcaggct agtggcagcg gaagcatgtg ggaaatagca agtccagtcccaccccaacc

77761 tactgaacca gcgtctgcat tttaacaggg tgccccagtg attcacgtgaccttcaaagt

77821 ctgaggagcc ctggagtagg gcccagggcc caggcctgag agagaggcctggggctaaga

77881 ctagccctga ccatgacctt gggcaagtca cacccctcac tgagcctcagtttgcttctc

77941 catcaaatgg gtgtttttct ttcagtccca gtcctctcct gaggcttttcccagaggtca

78001 tgcccagccc tgggcagggg tgagggcagg gttgtggctg ccaggcacaggtccagcggg

78061 ctgggagtcc tcaccatggc tggctgtgct gattatggtt gcatggggctgggaagaggt

78121 cccatttctg agccacagaa acaggccaca tccagtaggg gtcctggaaggctgtgagaa

78181 cccagaggag accctgaccc agcctgcagg tagaagactg cctttggaggcagctttgaa

78241 agatgactct tccagatgga agaatcagga agggccttcc cacgtggaggcaccagcagg

78301 agcaaacgtc cctggtgtgt tcaggcaaag agccacagga gagtgacctcgtggagtggg

78361 aagagattgt ttcccattcc cttgccaggg attggttgag gaatggacaaggcttgcagt

78421 tcacgcaagc cagtgaaatg cgaggggaag tcttgggagt ggggtggaggaggtcatctg

78481 ggaagggtgt ccttggtctt aaaaagaggc acaagaggcc gggcgcggtggctcttgcct

78541 attatcctag cactttggga ggccaaggca gggggatcac ttgaggtcaggagttcgaga

78601 ccagcctggc caacatggtg aaaccccgtc tctactaaaa atacaaaaaattagccagac

78661 gtggtgccaa gcacctgtaa tcccagctac tcaggaggct gaggcaggagaatcacttga

78721 acccaggagg cagaagttgc agtgagccaa gatcgcgcca ctgcactccagcctgtgtga

78781 caagggcgaa actccatctc aaaaaaaaag ggggagggtg gcgcaaggagaggacacctc

78841 tctcctggcc ctgtcgccat cttccctcat caatagctaa aaatggcaaagaagaaagag

78901 ccaggacccc gtgccatcaa atcctccggc cttgtgctgc cctgtctcggcactgcttgc

78961 cttaggagat caggagtgtt cctagccact gggagatggg atgcctgccactggcagctc

79021 tgccgtccat cctcaccatc ccaccgtccc cccaagacag ctctccatcccatcctctgc

79081 ctcccttcta gcctcaacct aactcagggc tcccccgtct cacacctgggttgcaggaac

79141 atcctcttca ccaacccccc tcccatccct cctcagggct gcctagggcagctacaaaaa

79201 ccaggccagc ctctgaaagg tgctccacat ctcattaaaa accgtgaaatcgcactgccc

79261 cactatcaga atagctcaga ggagaaggtc tgccagtacc aagtgctggtggggatacgg

79321 agaagagcag ctcccaggcg ctgctggtgc aaatgtgctt tgttgcacccacggcaggaa

79381 actgaccagc ttctcatcaa gttaaatacg catctaccct atggcctagcatttccactc

79441 ttgcttacac atccaggaga aatgagtcct tacatgcaca aaaggatgagtaccgtaata

79501 ctcacatcag caaataaaca atacagctgt gtgtcagtag tagaatgaataaattgtggt

79561 cgattcata

硬纤毛蛋白

STRC基因编码硬纤毛蛋白，一种通常在内耳中表达并与内耳中特化的毛细胞的静纤毛相关联的蛋白(参见，例如，Verpy等人，Nature456:255-258,2008；和Zhang等人，J.Med.Genet.44:233-240,2007)。长度为约10-50μm的静纤毛对于听力和平衡是重要的。静纤毛在听力中起着机械感应作用。通过响应于声音而弯曲，它们形成了机械接收声音刺激的结构。

人STRC基因位于染色体15q15上。其包含29个外显子，涵盖约19千碱基(kb)(Verpy等人，Nature Genetics 29(3):345-349,2001；NCBI登录号NG011636.1)。所述基因以端粒至着丝粒的取向在染色体15q15上串联复制，其中串联拷贝在染色体上的间隔小于100kb。第二拷贝的编码序列间杂有外显子20中的终止密码子，这意味着其是编码非功能性截短蛋白的“假基因”。(此后，提及“STRC基因”意指在外显子20中没有终止密码子的基因，而提及“假基因”或“STRC假基因”则表示在外显子20中具有终止密码子的基因)。在一些实例中，全长STRC蛋白是全长野生型STRC蛋白。从人STRC基因表达的全长野生型STRC蛋白的长度为1775个残基，并包含信号肽和几个疏水区段。当信号肽在野生型蛋白的加工过程中被切割掉时，所得的成熟野生型硬纤毛蛋白的长度为1719个残基。在一些实施方案中，全长STRC蛋白可包含位于成熟野生型硬纤毛蛋白的氨基酸序列的N-末端的异源信号肽。

STRC基因中的各种突变已与听力损失(例如，非症状性感音神经性听力损失)相关联。例如，在具有常染色体隐性非综合征性感音神经性耳聋-16(DFNB16)的近亲巴基斯坦家族中的外显子13中鉴定出纯合的1bp插入(Verpy等人(2001)。在具有DFNB16的家族中发现的另一个实例包括外显子5中的4bp缺失和涵盖外显子17-29的较大缺失。这两个缺失分别遗传自父亲和母亲。预测4bp缺失会导致5个框外氨基酸的翻译和外显子5中的提前终止密码子。

在具有非症状性感音神经性听力损失的受试者中检测到的硬纤毛蛋白基因中的其它示例性突变以及编码硬纤毛蛋白的核酸的测序方法描述于例如Verpy等人，Nature456:255-259,2008；Verpy等人，Res.Systems Neurosci.519:194-210,2011；Hofrichter等人，Clinical Genetics 87:49-55,2015和Mandelker等人，J.Mol.Diagnostics 16:639-647,2014中。检测基因中的突变的方法是本领域公知的。此类技术的非限制性实例包括：实时聚合酶链式反应(RT-PCR)、PCR、测序、Southern印迹和Northern印迹。

示例性人野生型硬纤毛蛋白为或包括SEQ ID NO:34的序列。编码野生型硬纤毛蛋白的核酸的非限制性实例为或包括SEQ ID NO:35和SEQ ID NO:36。如在本领域中可理解的，可对SEQ ID NO:35中的至少一些或全部密码子进行密码子优化以允许在非人哺乳动物中或人中的最佳表达。

在本文所述的任何组合物的一些实施方案中，STRC蛋白包含与SEQ ID NO:34具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。

人全长野生型硬纤毛蛋白(SEQ ID NO:34)(信号序列以粗体显示)

人野生型硬纤毛蛋白cDNA(SEQ ID NO:35)

atggctctcagcctctggcccctgctgctgctgctgctgctgctgctgctgctgtcctttgcagtgactctggcccctactgggcctcattccctggaccctggtctctccttcctgaagtcattgctctccactctggaccaggctccccagggctccctgagccgctcacggttctttacattcctggccaacatttcttcttcctttgagcctgggagaatgggggaaggaccagtaggagagcccccacctctccagccgcctgctctgcggctccatgattttctagtgacactgagaggtagccccgactgggagccaatgctagggctgctaggggatatgctggcactgctgggacaggagcagactccccgagatttcctggtgcaccaggcaggggtgctgggtggacttgtggaggtgctgctgggagccttagttcctgggggcccccctaccccaactcggcccccatgcacccgtgatgggccgtctgactgtgtcctggctgctgactggttgccttctctgctgctgttgttagagggcacacgctggcaagctctggtgcaggtgcagcccagtgtggaccccaccaatgccacaggcctcgatgggagggaggcagctcctcactttttgcagggtctgttgggtttgcttaccccaacaggggagctaggctccaaggaggctctttggggcggtctgctacgcacagtgggggcccccctctatgctgcctttcaggaggggctgctccgtgtcactcactccctgcaggatgaggtcttctccattttggggcagccagagcctgataccaatgggcagtgccagggagttttcttccttactctttccctcctaggtaaccttcaacagctgctcttatggggcgtccggcacaacctttcctgggatgtccaggcgctgggctttctgtctggatcaccacccccaccccctgccctccttcactgcctgagcacgggcgtgcctctgcccagagcttctcagccgtcagcccacatcagcccacgccaacggcgagccatcactgtggaggccctctgtgagaaccacttaggcccagcaccaccctacagcatttccaacttctccatccacttgctctgccagcacaccaagcctgccactccacagccccatcccagcaccactgccatctgccagacagctgtgtggtatgcagtgtcctgggcaccaggtgcccaaggctggctacaggcctgccacgaccagtttcctgatgagtttttggatgcgatctgcagtaacctctccttttcagccctgtctggctccaaccgccgcctggtgaagcggctctgtgctggcctgctcccaccccctaccagctgccctgaaggcctgccccctgttcccctcaccccagacatcttttggggctgcttcttggagaatgagactctgtgggctgagcgactgtgtggggaggcaagtctacaggctgtgccccccagcaaccaggcttgggtccagcatgtgtgccagggccccaccccagatgtcactgcctccccaccatgccacattggaccctgtggggaacgctgcccggatgggggcagcttcctggtgatggtctgtgccaatgacaccatgtatgaggtcctggtgcccttctggccttggctagcaggccaatgcaggataagtcgtgggggcaatgacacttgcttcctagaagggctgctgggcccccttctgccctctctgccaccactgggaccatccccactctgtctgacccctggccccttcctccttggcatgctatcccagttgccacgctgtcagtcctctgtcccagctcttgctcaccccacacgcctacactatctcctccgcctgctgaccttcctcttgggtccaggggctgggggcgctgaggcccaggggatgctgggtcgggccctactgctctccagtctcccagacaactgctccttctgggatgcctttcgcccagagggccggcgcagtgtgctacggacgattggggaatacctggaacaagatgaggagcagccaaccccatcaggctttgaacccactgtcaaccccagctctggtataagcaagatggagctgctggcctgctttagtcctgtgctgtgggatctgctccagagggaaaagagtgtttgggccctgcagattctagtgcaggcgtacctgcatatgcccccagaaaacctccagcagctggtgctttcagcagagagggaggctgcacagggcttcctgacactcatgctgcaggggaagctgcaggggaagctgcaggtaccaccatccgaggagcaggccctgggtcgcctgacagccctgctgctccagcggtacccacgcctcacctcccagctcttcattgacctgtcaccactcatccctttcttggctgtctctgacctgatgcgcttcccaccatccctgttagccaacgacagtgtacagcagggctacagagggtcagaggaaaacagtttggaggaagacaaagggttaagacccatgactcctcgcagcctggctgccatccgggattacagcccaggaatgaggcctgaacagaaggaggctctggcaaagcgactgctggcccctgaactgtttggggaagtgcctgcctggccccaggagctgctgtgggcagtgctgcccctgctcccccacctccctctggagaactttttgcagctcagccctcaccagatccaggccctggaggatagctggccagcagcaggtctggggccagggcatgcccgccatgtgctgcgcagcctggtaaaccagagtgtccaggatggtgaggagcaggtacgcaggcttgggcccctcgcctgtttcctgagccctgaggagctgcagagcctagtgcccctgagtgatccaacggggccagtagaacgggggctgctggaatgtgcagccaatgggaccctcagcccagaaggacgggtggcatatgaacttctgggtgtgttgcgctcatctggaggagcggtgctgagcccccgggagctgcgggtctgggcccctctcttctctcagctgggcctccgcttccttcaggagctgtcagagccccagcttagagccatgcttcctgtcctgcagggaactagtgttacacctgctcaggctgtcctgctgcttggacggctccttcctaggcacgatctatccctggaggaactctgctccttgcaccttctgctaccaggcctcagcccccagacactccaggccatccctaggcgagtcctggtcggggcttgttcctgcctggcccctgaactgtcacgcctctcagcctgccagaccgcagcactgctgcagacctttcgggttaaagatggtgttaaaaatatgggtacaacaggtgctggtccagctgtgtgtatccctggtcagcagcctattcccaccacctggccagactgcctgcttcccctgctcccattaaagctgctacaactggattccttggctcttctggcaaatcgaagacgctactgggagctgccctggtctgagcagcaggcacagtttctctggaagaagatgcaagtacccaccaaccttaccctcaggaatctgcaggctctgggcaccctggcaggaggcatgtcctgtgagtttctgcagcagatcaactccatggtagacttccttgaagtggtgcacatgatctatcagctgcccactagagttcgagggagcctgagggcctgtatctgggcagagctacagcggaggatggcaatgccagaaccagaatggacaactgtagggccagaactgaacgggctggatagcaagctactcctggacttaccgatccagttgatggacagactatccaatgaatccattatgttggtggtggagctggtgcaaagagctccagagcagctgctggcactgacccccctccaccaggcagccctggcagagagggcactacaaaacctggctccaaaggagactccagtctcaggggaagtgctggagaccttaggccctttggttggattcctggggacagagagcacacgacagatccccctacagatcctgctgtcccatctcagtcagctgcaaggcttctgcctaggagagacatttgccacagagctgggatggctgctattgcaggagtctgttcttgggaaaccagagttgtggagccaggatgaagtagagcaagctggacgcctagtattcactctgtctactgaggcaatttccttgatccccagggaggccttgggtccagagaccctggagcggcttctagaaaagcagcagagctgggagcagagcagagttggacagctgtgtagggagccacagcttgctgccaagaaagcagccctggtagcaggggtggtgcgaccagctgctgaggatcttccagaacctgtgccaaattgtgcagatgtacgagggacattcccagcagcctggtctgcaacccagattgcagagatggagctctcagactttgaggactgcctgacattatttgcaggagacccaggacttgggcctgaggaactgcgggcagccatgggcaaagcaaaacagttgtggggtcccccccggggatttcgtcctgagcagatcctgcagcttggtaggctcttaataggtctaggagatcgggaactacaggagctgatcctagtggactggggagtgctgagcaccctggggcagatagatggctggagcaccactcagctccgcattgtggtctccagtttcctacggcagagtggtcggcatgtgagccacctggacttcgttcatctgacagcgctgggttatactctctgtggactgcggccagaggagctccagcacatcagcagttgggagttcagccaagcagctctcttcctcggcaccctgcatctccagtgctctgaggaacaactggaggttctggcccacctacttgtactgcctggtgggtttggcccaatcagtaactgggggcctgagatcttcactgaaattggcaccatagcagctgggatcccagacctggctctttcagcactgctgcggggacagatccagggcgttactcctcttgccatttctgtcatccctcctcctaaatttgctgtggtgtttagtcccatccaactatctagtctcaccagtgctcaggctgtggctgtcactcctgagcaaatggcctttctgagtcctgagcagcgacgagcagttgcatgggcccaacatgagggaaaggagagcccagaacagcaaggtcgaagtacagcctggggcctccaggactggtcacgaccttcctggtccctggtattgactatcagcttccttggccacctgctatga

人野生型硬纤毛蛋白cDNA-经密码子优化的(SEQ ID NO:36)

atggctctgtctctgtggcctctgctgctgctcctgttgctgcttctgctgctcagcttcgccgtgacactggctccaacaggaccccactctctggatcctggcctgagctttctgaagtccctgctgagcaccctggatcaggctcctcagggcagcctgagcagatccagattcttcaccttcctggccaacatcagcagcagcttcgagcctggcagaatgggagaaggacctgtgggagaacctcctccactgcaacctccagctctgcggctgcacgattttctggtcacactgagaggcagccccgactgggaacctatgctgggactgctgggagatatgctggccctgctcggacaagagcagacccctagagatttcctggtgcatcaggctggcgtgctcggaggactggttgaagttctgcttggagcactggtgcctggcggacctcctacacctacaagacctccatgcaccagagatggccccagcgattgtgtgctggctgctgattggctgcctagcctgctcctgcttctggaaggcacaagatggcaggccctggtgcaggttcagccttctgtggatcctaccaatgccaccggcctggatggaagagaagccgctccacactttctgcagggactgcttggactgctcacacctactggcgagctgggctctaaagaagccctttggggaggcctgctgagaacagttggagcccctctgtacgccgcctttcaagagggactcctgagagtgacacacagcctgcaggacgaggtgttcagcatcctgggacagccagagcctgacaccaatggacagtgtcagggcgtgttctttctgaccctgagcctgctgggcaacctgcagcaactgcttctgtggggcgtcagacacaacctgagctgggatgtgcaggcactgggctttctgtctggaagccctccacctccaccagcactgctgcattgtctgtctactggcgtgccactgcctagagcctctcagcctagcgctcacatcagccccagacagagaagggccatcaccgtggaagctctgtgcgagaatcacctgggacctgctcctccatacagcatcagcaacttctccatccatctgctgtgtcagcacaccaagcctgccacacctcagcctcatcctagcaccacagccatctgtcagaccgccgtttggtacgccgtttcttgggctcctggtgctcaaggatggctgcaggcctgtcacgatcagttccccgacgagttcctggacgccatctgcagcaatctgagcttctctgccctgtccggcagcaatcggagactggtcaaaagactgtgcgccggactgctgcctcctccaacatcttgtcctgagggactgcctcctgtgcctctgactcccgatatcttttggggctgcttcctggaaaacgagacactgtgggccgagagactgtgtggcgaagcctctctgcaagccgtgcctccatctaatcaggcctgggtgcagcacgtttgtcagggccctacacctgacgtgacagcctctcctccttgtcacatcggaccttgcggcgagagatgtcctgatggcggcagctttctcgtgatggtctgcgccaacgacactatgtacgaggtgctggtgcccttctggccttggctggctggccagtgtagaatctccagaggcggcaacgatacctgtttcctggaaggactcctgggaccactgcttccatctctgcctccgcttggaccctctcctctgtgtcttacccctggacctttcctgctggggatgctgtctcagctgcctagatgccagtctagcgtgccagctctggcccatccaaccagactgcactatctgttgcggctgctgaccttcctccttggacctggcgctggcggagctgaagctcaaggcatgcttggcagagccctgctgctgtcatccctgcctgacaactgcagcttctgggacgccttcagacctgaaggacgcagaagcgtgctgaggaccatcggcgagtacctggaacaggatgaggaacagcctacaccaagcggcttcgaacccaccgtgaatcctagcagcggcatctccaagatggaactgctggcctgcttcagccccgtgctgtgggatctgctgcagagggaaaaaagcgtgtgggccctgcagatcctggtccaggcctatctgcacatgcctccagagaacctgcaacagctggtgctgtctgccgagagagaagctgcccagggattcctgactctgatgctgcagggaaagctgcagggcaaactccaggtgccacctagcgaagaacaggcccttggcagactgacagcactcctgctccagagataccccagactgacctctcagctgtttatcgatctgagccctctgatcccattcctggccgtgtccgacctgatgagattccctcctagtctgctggccaacgactccgtgcagcagggatacagaggcagcgaggaaaacagcctggaagaggacaaaggcctgcggcctatgacacctagatctctggccgccatccgggattacagccctggaatgaggcccgagcagaaagaggccctggctaagagactgctggctcccgagctgtttggcgaagttccagcctggcctcaagaactgctgtgggctgttctgcccctgctgccacatctgcctctggaaaacttcctgcagctgagcccacaccagattcaggccctcgaggattcttggcctgccgctggactcggacctggacatgctagacacgtgctgagaagcctggtcaaccagagcgttcaggacggcgaggaacaagtgcggagacttggacccctggcctgttttctgagccccgaggaactgcagagtctggtgcctctgtctgaccctacaggccctgttgaaaggggcctgctggaatgtgccgccaatggaacactgagccctgagggcagagtggcctatgaacttctgggagtgctgagatctagcggcggagccgttctgtcccctagggaacttagagtgtgggcacccctgtttagccagctgggcctgagattcctgcaagagctgtctgagccacagctgagggctatgctgcctgtgctccagggcacatctgtgacaccagctcaagccgtcctgctgttgggcagactgctccctagacacgatctgtccctggaagaactgtgcagcctgcacttgctgctgcctggactgtctcctcagacactgcaggccattcctcggagagtgcttgtgggagcctgtagctgtctggcccctgagctgtctagactgagcgcctgtcaaacagccgctctcctgcagaccttcagagtgaaggatggcgtgaagaacatgggcaccacaggcgctggacctgccgtgtgtattcctggacagcagcccattcctaccacctggccagattgtctgctcccactgctgcccctgaaactgctgcagctggattctctggctctgctggctaaccggcggagatattgggaactgccttggagcgaacagcaggcacagttcctgtggaagaagatgcaggtccccaccaatctgacactgcggaatctgcaggctctcggcacacttgctggcggaatgagctgcgagttcctccagcagatcaacagcatggtggactttctggaagtggtgcacatgatctaccagctgccaaccagagtgcggggaagcctgagagcttgtatttgggctgaactgcagcggcggatggccatgcctgaacctgaatggacaacagtgggccccgagctgaacggcctggactctaaacttctgctggatctccccatccagctgatggacagactgagcaacgagagcatcatgctggtggtggaactggtgcagagagccccagaacagctgctggcactgacacctctgcatcaagctgctctggccgaacgggcccttcagaatctggctcccaaagaaacccctgtgtccggggaagtgctggaaacactgggacctcttgtgggcttcctgggcaccgagtctaccagacagattcctctccagatcctgctgtcccacctgagccagctccagggattttgtctgggcgagacattcgccaccgaactcggatggttgctgctccaagagagcgtgctgggaaagcccgaactgtggtcacaggacgaagtggaacaggccggcagactggtgtttaccctgtctaccgaggccatcagtctgatccccagagaagcactgggccctgaaacactcgagaggctgctggaaaagcagcagtcttgggaacagagcagagtgggccagctgtgtagagaacctcagctggccgctaaaaaggccgcactggttgctggcgttgtcagacctgctgccgaggatctgccagagccagtgcctaattgtgccgatgtgcggggcacatttcctgccgcttggagcgctacacagatcgccgaaatggaactgagcgacttcgaggactgtctgactctgtttgccggcgatcctggactgggaccagaagaactgagagccgccatgggcaaagccaagcaactttggggacctccaagaggcttcagacccgaacagattctgcagctcggccgcctgcttatcggactgggcgatagagagctgcaagaactgatcctggtggactggggcgtgctgtctactctgggacaaatcgacggctggtccaccacacagctgcggattgtggtgtccagcttcctgaggcagtctggcagacatgtgtctcacctggacttcgtgcacctgactgccctgggctacacactgtgtggactgcggcctgaggaacttcagcacatcagctcttgggagttcagccaggcagccctgtttctgggaaccctgcatctgcagtgctccgaagaacaactggaagtgctcgcccatctgctcgtgctgccaggcggatttggccccatctctaattggggacccgagatcttcaccgagatcggcaccattgccgctggcatccctgatctggccctgtctgcactgctgagaggacagatccagggcgtgacaccactggccattagcgtgatccctccaccaaagttcgccgtggtgtttagccccattcagctgtccagcctgacatctgcccaagccgtggctgtgacccctgaacagatggcatttctgtctcccgagcagcggagagctgttgcttgggctcaacacgagggcaaagagagtcctgagcaacagggaagaagcaccgcttggggactgcaggattggtccagaccttcttggtcactggtgctgaccatcagctttctgggccacctcctgtga

人野生型硬纤毛蛋白(Stereocilin)基因DNA序列的非限制性实例是SEQ ID NO:37。SEQ ID NO:37中的外显子是：核苷酸位置1-142(外显子1)、核苷酸位置445-1230(外显子2)、核苷酸位置1319-1343(外显子3)、核苷酸位置2111-3368(外显子4)、核苷酸位置4325-4387(外显子5)、核苷酸位置4489-4605(外显子6)、核苷酸位置4748-4914(外显子7)、核苷酸位置5570-5756(外显子8)、核苷酸位置5895-6010(外显子9)、核苷酸位置6292-6424(外显子10)、核苷酸位置6777-6959(外显子11)、核苷酸位置7264-7302(外显子12)、核苷酸位置7486-7653(外显子13)、核苷酸位置7817-7882(外显子14)、核苷酸位置8364-8489(外显子15)、核苷酸位置9467-9525(外显子16)、核苷酸位置10598-10721(外显子17)、核苷酸位置10826-10938(外显子18)、核苷酸位置13402-13537(外显子19)、核苷酸位置13955-14151(外显子20)、核苷酸位置14350-14440(外显子21)、核苷酸位置14649-14805(外显子22)、核苷酸位置15390-15559(外显子23)、核苷酸位置17250-17405(外显子24)、核苷酸位置17787-17929(外显子25)、核苷酸位置18119-18267(外显子26)、核苷酸位置18509-18605(外显子27)、核苷酸位置18694-18841(外显子28)和核苷酸位置19041-19238(外显子29)。内含子位于SEQ ID NO:37中的这些外显子中的每一个外显子之间，即，处于核苷酸位置143-444(内含子1)、核苷酸位置1231至1318(内含子2)、核苷酸位置1344-2110(内含子3)、核苷酸位置3369-4324(内含子4)、核苷酸位置4388-4488(内含子5)、核苷酸位置4606-4747(内含子6)、核苷酸位置4915-5569(内含子7)、核苷酸位置5757-5894(内含子8)、核苷酸位置6011-6291(内含子9)、核苷酸位置6425-6776(内含子10)、核苷酸位置6960-7263(内含子11)、核苷酸位置7303-7485(内含子12)、核苷酸位置7654-7816(内含子13)、核苷酸位置7883-8363(内含子14)、核苷酸位置8490-9466(内含子15)、核苷酸位置9526-10597(内含子16)、核苷酸位置10722-10825(内含子17)、核苷酸位置10939-13401(内含子18)、核苷酸位置13538-13954(内含子19)、核苷酸位置14152-14349(内含子20)、核苷酸位置14441-14648(内含子21)、核苷酸位置14806-15389(内含子22)、核苷酸位置15560-17249(内含子23)、核苷酸位置17406-17786(内含子24)、核苷酸位置17930-18118(内含子25)、核苷酸位置18268-18508(内含子26)、核苷酸位置18606-18693(内含子27)和核苷酸位置18842-19040(内含子28)。

人野生型硬纤毛蛋白基因(SEQ ID NO:37)(NCBI登录号NG_011636.1)

1 gccctgccct cacctggcta tcccacacag gtgagaataa ccagaactca cctccggtac

61 cagtgttcac ttggaaacat ggctctcagc ctctggcccc tgctgctgct gctgctgctg

121 ctgctgctgc tgtcctttgc aggtaagaag aacagtgagc agaactgggg atgaggagga

181 gggtggctgg aaaaagactt taagaatatg gaggtgaacc tgttagatag aaggacaaag

241 gagagaggca gagacttgtg caaaagggaa aaatgagggt taagaaaagc aggccaagac

301 ttactgtagg ccagtgaaag gggttcagct caccatcccc tcacctcatc tttagatcca

361 ggtagggaac tgtgctcagg ggcagggttg agtttgggct ctgtgttcct ctccttcagt

421 gacctctggt ttctctcctt acagtgactc tggcccctac tgggcctcat tccctggacc

481 ctggtctctc cttcctgaag tcattgctct ccactctgga ccaggctccc cagggctccc

541 tgagccgctc acggttcttt acattcctgg ccaacatttc ttcttccttt gagcctggga

601 gaatggggga aggaccagta ggagagcccc cacctctcca gccgcctgct ctgcggctcc

661 atgattttct agtgacactg agaggtagcc ccgactggga gccaatgcta gggctgctag

721 gggatatgct ggcactgctg ggacaggagc agactccccg agatttcctg gtgcaccagg

781 caggggtgct gggtggactt gtggaggtgc tgctgggagc cttagttcct gggggccccc

841 ctaccccaac tcggccccca tgcacccgtg atgggccgtc tgactgtgtc ctggctgctg

901 actggttgcc ttctctgctg ctgttgttag agggcacacg ctggcaagct ctggtgcagg

961 tgcagcccag tgtggacccc accaatgcca caggcctcga tgggagggag gcagctcctc

1021 actttttgca gggtctgttg ggtttgctta ccccaacagg ggagctaggctccaaggagg

1081 ctctttgggg cggtctgcta cgcacagtgg gggcccccct ctatgctgcctttcaggagg

1141 ggctgctccg tgtcactcac tccctgcagg atgaggtctt ctccattttggggcagccag

1201 agcctgatac caatgggcag tgccagggag gtgagtgtgg ccagggctgggactgggatg

1261 tggcagggca aggaaagtga aattggggta gttttcttcc ttactctttccctcctaggt

1321 aaccttcaac agctgctctt atggtaagta acaggagacc agttctgagggattgggcct

1381 ggaaaatctg gaggtgaaga gctgaagacc tcagcctcta gagaggaaaactgatgggag

1441 gagtgtagtt tagtggtttt ggggtgtgac tgtctgggtt ggtgtcccagctccacctct

1501 tcctagccat atgaccttga gcaggttaca tagtctttct atacctcagtttccccattt

1561 ataaaatgag aatgataata ttagttacca cagagttgtt gcacccggttaaatgagttg

1621 atactgtgta tgcaaacgac ttaaaaccgt gctggcacat agcgcttaataatgttagct

1681 agtaaagatg ggatttggaa aataaggaca cagctggatt cctctacccccttactactt

1741 cagtacaaca atgccagaca gtagttagac atattgagtt gctgagcagatttcctaaca

1801 tgaggcccgc tgagggttgt gtttaagcta tctaaaagca tacgaagaaaggagacagaa

1861 gggggccagg tggacagaaa gaattccaac tggggcttct cctaggtgattttggacctt

1921 ggcagggcag ctttctcttt tttgccccgt tgcagcattt caaccagtaacgcctaaact

1981 ctcagggacc tcgcttgtag aaaagcctat gcttgccatg ccccttgagggctctgagtc

2041 agggtcagaa tcttcagctg gaggaaatgt gaactgacca gatcctgcctgctcctccct

2101 ctgcacccag gggcgtccgg cacaaccttt cctgggatgt ccaggcgctgggctttctgt

2161 ctggatcacc acccccaccc cctgccctcc ttcactgcct gagcacgggcgtgcctctgc

2221 ccagagcttc tcagccgtca gcccacatca gcccacgcca acggcgagccatcactgtgg

2281 aggccctctg tgagaaccac ttaggcccag caccacccta cagcatttccaacttctcca

2341 tccacttgct ctgccagcac accaagcctg ccactccaca gccccatcccagcaccactg

2401 ccatctgcca gacagctgtg tggtatgcag tgtcctgggc accaggtgcccaaggctggc

2461 tacaggcctg ccacgaccag tttcctgatg agtttttgga tgcgatctgcagtaacctct

2521 ccttttcagc cctgtctggc tccaaccgcc gcctggtgaa gcggctctgtgctggcctgc

2581 tcccaccccc taccagctgc cctgaaggcc tgccccctgt tcccctcaccccagacatct

2641 tttggggctg cttcttggag aatgagactc tgtgggctga gcgactgtgtggggaggcaa

2701 gtctacaggc tgtgcccccc agcaaccagg cttgggtcca gcatgtgtgccagggcccca

2761 ccccagatgt cactgcctcc ccaccatgcc acattggacc ctgtggggaacgctgcccgg

2821 atgggggcag cttcctggtg atggtctgtg ccaatgacac catgtatgaggtcctggtgc

2881 ccttctggcc ttggctagca ggccaatgca ggataagtcg tgggggcaatgacacttgct

2941 tcctagaagg gctgctgggc ccccttctgc cctctctgcc accactgggaccatccccac

3001 tctgtctgac ccctggcccc ttcctccttg gcatgctatc ccagttgccacgctgtcagt

3061 cctctgtccc agctcttgct caccccacac gcctacacta tctcctccgcctgctgacct

3121 tcctcttggg tccaggggct gggggcgctg aggcccaggg gatgctgggtcgggccctac

3181 tgctctccag tctcccagac aactgctcct tctgggatgc ctttcgcccagagggccggc

3241 gcagtgtgct acggacgatt ggggaatacc tggaacaaga tgaggagcagccaaccccat

3301 caggctttga acccactgtc aaccccagct ctggtataag caagatggagctgctggcct

3361 gctttagtgt gagtgctctg ccagagggaa agctcctaga acagtgagaaggccctccag

3421 gggaattcct cgaatactca gaggcagtag tgtggggtag tagttgaagcacacagctct

3481 agagtcagac aggcttggat tcatatcttg gttctgtgac cagccttgaatgagttattt

3541 aacttctctg agcaatattt ttctcgtctc atttataaac tagggatgataatggtatat

3601 gagataatac atgctgtggg cttagcacag tgcatgatac acaaacatgcaataaatatt

3661 accttgttat tcttttgggc tctttgactc tctcactttc tgcaccagaaagaaaaagga

3721 tcaagttaga ggactctaaa tttttcccct agagagtgag aattggaggctggcagaata

3781 caggaagata aggtaggaat gagaaagatt cagggacact accaatcagaagactttggt

3841 tctaggttca actgtgccac aaattagtgt gatcttaggc aagcaatttcatttagtttt

3901 tctgggcttc agtttttagt ctgtagaatg gaggggtgag aatatgttaaacaccataat

3961 taattcactg agtgcctatt atatgcaagg cactttgcta ggttctgtaggatatataaa

4021 gatttcttac tccatgttgg ggccaccttt ttcaaaccct gggcccagtaaaatggaatt

4081 agatagtctc atagtatttg gttcaggtct acaagtatta attgagccaactatggacct

4141 ggcatgggag agggtacaag agaaattaga gatatgatcc cggacctaaaagagcttaat

4201 atctgaagaa tcacacttga gatgatggac aagcatccca gcaagtggagctggaatgcc

4261 tgggggagct gcaggagaga cagagaagac agctctgttg gcatattgtctttcttccca

4321 ccagcctgtg ctgtgggatc tgctccagag ggaaaagagt gtttgggccctgcagattct

4381 agtgcaggta acaggtggag ggcacatggg tgggctgggt gacagccatggctggaggtc

4441 cctgccccgt gaggtgaggc catacccacc atgacctcct attcgcaggcgtacctgcat

4501 atgcccccag aaaacctcca gcagctggtg ctttcagcag agagggaggctgcacagggc

4561 ttcctgacac tcatgctgca ggggaagctg caggggaagc tgcaggtgagcactgagaaa

4621 ggggagcaag ggcacctgga gcctagtgtt cagagggctt gctttagtgggaggaggaac

4681 tccagagagg aaatggcagg gatactgagc atctccagag gcagaatccattcctgtgcc

4741 cctacaggta ccaccatccg aggagcaggc cctgggtcgc ctgacagccctgctgctcca

4801 gcggtaccca cgcctcacct cccagctctt cattgacctg tcaccactcatccctttctt

4861 ggctgtctct gacctgatgc gcttcccacc atccctgtta gccaacgacagtgtgtaagg

4921 ttcttgcact actcctcctg ctcctgtcac ggtcaggcca accgcatccacctggagcag

4981 ccccttccgg agctcctctc tgtttttttc tttcatgcca gataggcaatgtgccaacat

5041 cgtagcaagg tttgagagag gcacatctca cgcctgagtg tgaaaacccaatcattatgc

5101 taatgaacta caaaaggatc agagagctcc tctctattaa aaccagggagaggatgggcg

5161 tggtggctca tgcctgtaat cccagcacgt tgggagcccg aggcaggtggatcactaggt

5221 ccgcctagtg agttcgagac cagcctggcc aatatggtga aaccccgtctctattaaact

5281 acaaaaatta gccaggcatg gtggtgggcg cttgtagtcc cagttactctggaggctgag

5341 gcaggaggat agcttgaacc tgggaggcag aggttgcagt gaaccaagatcgtgccactg

5401 cactccagcc tgggtgacag agcgagactc cgtcttaaaa aaaacaaaaaacaaaacaaa

5461 acaaaaaaac agggagagtc tccttcctat ctagacagca gggctacagagggtcagagg

5521 aaaacagttt ggaggaagac aaagggttaa gacccatgac tcctcgcagcctggctgcca

5581 tccgggatta cagcccagga atgaggcctg aacagaagga ggctctggcaaagcgactgc

5641 tggcccctga actgtttggg gaagtgcctg cctggcccca ggagctgctgtgggcagtgc

5701 tgcccctgct cccccacctc cctctggaga actttttgca gctcagccctcaccaggtat

5761 gagaatcatc ttctttactt gactggccca tcttctgcta gtggggacaaagagtcaatg

5821 gcatgtctct cagtggcccc tccctgcaag aaccctatag tgaccccagtgcgagctaac

5881 cttccccatc tcagatccag gccctggagg atagctggcc agcagcaggtctggggccag

5941 ggcatgcccg ccatgtgctg cgcagcctgg taaaccagag tgtccaggatggtgaggagc

6001 aggtacgcag gtgagttgtt gtgggatcag taaccaaggc aagagtggaagaggtagaga

6061 gaggaaggca cagctgtcac gctgggtcgg tgttctagga agaaaggggcaagagagtag

6121 gcagtggcct caggcagcat agagttccag gagagaggtc tatagatggtgcccctgtgt

6181 agtggtgtag tgtcagagtg cccagtgtat gtacccatac catctgctgccaggcctgcc

6241 ttagtgctag tcttggggac cacacaaagg tcagcttcat gccctcctcaggcttgggcc

6301 cctcgcctgt ttcctgagcc ctgaggagct gcagagccta gtgcccctgagtgatccaac

6361 ggggccagta gaacgggggc tgctggaatg tgcagccaat gggaccctcagcccagaagg

6421 acgggtgagc ccctcagcac aagcctacaa gactttaggc ttcccctgggtctgtgtgga

6481 tggctttccc attgtgtcaa cttgagcaca gtggtgccag cccccatcccacttttgcaa

6541 cctccattcc ttactccatg gccattctta cctgttacca cctcttcctggcccttctct

6601 atctggtctg tagcacccca aacataccct ttgccatttt gaacctaatctactccagtc

6661 caatccctag ttccaaaccc tagcccaggc cctgggaaat tcagatgtgggattagagag

6721 gaagttcaag gttcatctgt cttttctctc cagtcctaaa ccttctttggttacaggtgg

6781 catatgaact tctgggtgtg ttgcgctcat ctggaggagc ggtgctgagcccccgggagc

6841 tgcgggtctg ggcccctctc ttctctcagc tgggcctccg cttccttcaggagctgtcag

6901 agccccagct tagagccatg cttcctgtcc tgcagggaac tagtgttacacctgctcagg

6961 tttgcctgtc tcactccctg gcatgtaccc tccatccccg cttgagccccagtcaagaga

7021 atcccattca gggataaaag cagcccctcc tttccctggg tgaacagtagaggtaaactc

7081 tgtctgcagg aggacgcctt cattcccttt cctcagatca agaagggacctgagtcactg

7141 aggatggtta ctagggatgg ttaagaggca gcgggaagtt ttggagggtttgccttagga

7201 acccacttag gacctggctg ctgggtcctg agagctgttg ttttcggtcccatcccaaca

7261 caggctgtcc tgctgcttgg acggctcctt cctaggcacg atgtgagtagcagcaacttc

7321 tcagcctccc gccagaggtc tctatcctct tttaacctgg ctcctgcatctgcccctcct

7381 ctctctccgc tcccctcata cttactgcct tgctgcattg tgattgttgtcttccccaac

7441 acccttccct tcttcttcag gcctcttgtc tctcttgctc tttagctatccctggaggaa

7501 ctctgctcct tgcaccttct gctaccaggc ctcagccccc agacactccaggccatccct

7561 aggcgagtcc tggtcggggc ttgttcctgc ctggcccctg aactgtcacgcctctcagcc

7621 tgccagaccg cagcactgct gcagaccttt cgggtatgag agtggcaaggaggatgagat

7681 aatcagggat accggctctt tctggttggg aggaaggcat cttccctgaggccagggaag

7741 gcctttcata cctccccact tacacacaca cacacacaca cacacacacacacacacaca

7801 accaattctc atgcaggtta aagatggtgt taaaaatatg ggtacaacaggtgctggtcc

7861 agctgtgtgt atccctggtc aggtaagtgt gagatctccc aactgagctcctctccccat

7921 tctggggcag tttcatatgg ctggtgctac ctcccacact accctgcagtggccctgaga

7981 gttctggtta gctctgtgcc cattagcagc cctccccagt gccagatgcaggacagcatg

8041 atccactcac attgtcctag actaatgtca aagctggaag ggcctgagaaatcttccagg

8101 ccacccaccc tgctttcaga tgaaaagacc aaggctggga gaagctaagggactttgttt

8161 gcctggtgcc taactagcag caacacttga ccacagcagc ctgcagtgtgaggctcttag

8221 gcgtttattg ctacagtggc aaatgccatt ccacttctgt cctagctttggtccctttcc

8281 acccccatgg ttccttttct ctgagtgcta agtacagact ctctcacctatcactacact

8341 gctataccca tcaccgccag cagcctattc ccaccacctg gccagactgcctgcttcccc

8401 tgctcccatt aaagctgcta caactggatt ccttggctct tctggcaaatcgaagacgct

8461 actgggagct gccctggtct gagcagcagg taattctccc cacttaatttcagaacttcc

8521 tccctcaatg tagtctacct tctttaccta tcccttagcc ctatttggccagcttatccc

8581 tactatcctt tatttgattg tttgagatac agtctcactc tgttgcccaggctgcagtgc

8641 agtggcatga tcagagttcg ctgtaacctc aaactcctga gctcaggcaatctttctgcc

8701 tcagcctcct gaatagctag gacgacaggt ggttaccacc atgcctggctaatttttaaa

8761 tttttttttt gttttttgag atgaagtctt gctctgtcac ccaggcttgagtacagtggc

8821 acaagcttgg ctcactgcaa cctctgtctc ccgggttcaa gcgattctcctgcctcagcc

8881 tcccgagtag ctgggactac aggcactccc cacaatgcct ggctaattttttttttgttt

8941 tagtagagac agggtttcac catattggcc aggctggtct cgaactgctgaccttgtgat

9001 ctgcctgcct ctgcctctca aagtgctggg attacaggtg tgagccaccatgcccggcca

9061 atttttaaat tttttgtaga gacagacaat acaaaaatgt ggacactatgtggagacact

9121 atgttgaggt actatgctgt ccagattggt cttgaactcc tggcctcaagcaatcctcct

9181 gccttggcct cccaaagtgc tgggattaca gacctgagcc actgcacccagccccctagt

9241 atctcttata atgtgacttg cttttctttt tctttctcct tcccttttctttcatttctt

9301 tctcactctc gagagaagag tgggcatctg ggagagtggg aggctggtgggtcccacaga

9361 gtgaggaggc aggactgggt ccaaggcagt cctgcctctc cactctagggggtatccttg

9421 gacagtgtct cttctgggaa ggggctcgtc tttctttctc ttgtaggcacagtttctctg

9481 gaagaagatg caagtaccca ccaaccttac cctcaggaat ctgcagtgagtaacttgtgt

9541 tgagcagtgc gctgaattcg accaacattt ttttgagtgc ttactatgtgccaggcacca

9601 tgtgatatgg aatgggggat atagggatga atgatgcata gtccctgcctcgtggacgtt

9661 ctcctagcac ctccctttgc cctcctttcc ttccacagtg ccatgcctatcctgactaga

9721 gccaaaggac tcagaaaacc tggattcagg ttccagtcct gtcacctacttgtcctcttg

9781 ggcaagtcat ttaacgtccc tgtgtcagtt ttcccttctt taaatgagaattacaatggc

9841 accagcctca taggtagtta ctgtgaagat taaatgaggt aggtcatgtaagatatttaa

9901 cacagtgttt ggtccattgt aaagtcccag tagtcatttg ctactgttagtttacttcag

9961 gatgacttca gaggcactgg ccaagcaaga ataaatagga ataagaaggtatcactttac

10021 ttacacccac attagaagaa caatgggctt cagaatcttt ttttttttttttttttcgag

10081 acagtcttgc tctgttgccc aggctggagt gcagtggcgc gatttcggctcactgcaacc

10141 tctgcctccc aggttcaagc gattctcctg tctcagcctc tggagtagctgggattacag

10201 gaatgtgcca ccatacccag ctaatttttg tatttttagt agagatggggtttcaccatt

10261 ttggccaggc tggtctcaaa ctcctgacct caggtgatcc acccgcctcagcctcccaag

10321 ggcttcagaa tctaagacat ggctctagtt tcagtttacc acatttctagcagaatgatg

10381 ttgggaatgt cacctgactt ccataaatcc ttattttctc ctctgataaacagcagtgat

10441 gttatgggga gctgatgaga tatctatgta aaaacatttc tcaaaccataaattacggtg

10501 gatgaacatc tgtacttgtg ttgagagtac tgatatcaag gagcaaacaggctgttgtat

10561 gtgttgaatg agcctctccc cactcacaca cccacagggc tctgggcaccctggcaggag

10621 gcatgtcctg tgagtttctg cagcagatca actccatggt agacttccttgaagtggtgc

10681 acatgatcta tcagctgccc actagagttc gagggagcct ggtgagagggggtgcctgga

10741 ctttagtggg agcagggagg ctgggaccct aggtatagaa cccagctcctatgttctgct

10801 ctggcctcac actgcttccc tacagagggc ctgtatctgg gcagagctacagcggaggat

10861 ggcaatgcca gaaccagaat ggacaactgt agggccagaa ctgaacgggctggatagcaa

10921 gctactcctg gacttaccgt aagtactgca gctagagata ttggcccctcagaaagctca

10981 atctggggtg aagatctgcc cttagggaat gccctggagg aggtagtttttctgtctggt

11041 agttccctga cataatttat agcccaaagc agaggatttt attcaaagttgctctatgta

11101 ttgactggtt cccagaatat gctccagcac agggcagctg agggtggcaacactgtattg

11161 aagcctgcca agtaatctta caataaccta gtccacatta attgagattgagacagagca

11221 tctgaagtga gggaggcaat gctccaaatc tgccccagag gattgtagtttgctcagggc

11281 actgtgttct tagtgcattc agaggagtag atcgagagaa aaatatatgaaaaatgtgat

11341 aaataccttc aaatacctga ggggctatca agtagaaatt agattgtcatatttatgagt

11401 ggccccattg ggcaagacta agagtagtta acggagatca gatttttacatagtataaga

11461 aaaactaagg tagtgagttc ctggtccttg gagctgttcg agcctaagccagatggcccc

11521 atggcaggaa tgttgtagag cacgttcata tacaggttgt gggaagaaaaggctatagga

11581 acccaaggct cctccctacc catggagaaa tttattagta tgttactcatatgctgcttt

11641 tctcatttta cccctaccac caccccgttg ccatccgcac tgtaagtcaggataggaaaa

11701 tgctggtgtt acagtcttcc tggggaatat ggagctgaag tggagtaaaagcagttgact

11761 tcattcctac ttttttcttt tttttctttt tttttttttt tgagacagagttttgctgtg

11821 tcaccaaggc tggagtgcag tgacgtgatc tcggctcact gcaacctccatcttccaggt

11881 tcaagcaatt ctcctgcctc agtctcccga gtagctggga ctgtaggtgtgcaccaccat

11941 gccaggctaa tttttgtatt tgttgtaggg acgagctttc accatgttggccaggctggt

12001 cttgaactcc tggcttcaag tgatctgccc acctcggctt cccaacattcttatattttt

12061 ataggccttt ccacagattt cagctcttgt atgacttagc ccagttccagaactggtaat

12121 cctaggtagg gtacaggtta tcacctctga tttcgggtaa aagggatttatttatttatt

12181 tgtttattta tttatatttt tgagacagag tctcgctctg tcacccaggctggagtgcaa

12241 tggtgccatc tcggctcact gcaacctctc cctctggggt tcaagcaattctcctgcctc

12301 agcctgctga gtagctggga ttacaggcgc gtgccaccac acccggctaatttttgcatt

12361 tttagtagag acggggtttc accatgttgc tcagggtggt ctcgaatttctgaccctgtg

12421 atctgcctgc ctcggcctcc caaagtgctg ggattacagg catgagccactgcgtccggc

12481 ctgtttttac ttttttttaa tgccattcag atctgtttaa atatgtgggttctgtgagat

12541 aatttagaat cccaaggtta cagatgaggt gaaagatcct agaccatgcatcaaaaaact

12601 tgagtttctc atttgtgaaa gaaggataag agaaacacct attttgtctgggtgcagtgg

12661 ctcatgccta taatcccagc atttggggag gccaaggtgg gtggatcacggaggtcaggt

12721 gttcaagacc agactggcca acatggcaaa acaccatctc tactaaaaatacaaaagtta

12781 gctgggcgtg gtggcacgtg cgtgtaattc cagctattcg ggaggctgaggcacgagaat

12841 tgcttgaacc tgggaggtgc gggttgcagt gaactgagat cgcagcaccactgtgctcca

12901 gcctgagtga tggagtgagg ccaggtcttg ttgtaggatc aaatgagataacacctgaaa

12961 gaactttgta aattgtatag cacgtacaaa caagaaggga cctcttcacaagcagaggaa

13021 gggtggtcct gtggaaaaaa acgggaattg ggagtgagag acctcaacatttgatctctg

13081 tgaacctcag ttttttaatc tataaaatgg ggaaatgtta atggtacttaatatttggag

13141 cttttgagtc cattagatca ggtaggattg ttcgttattt tttttttttaggaagactag

13201 aaatatgttg ctcccttttt ctcccccact caagcttgat ggtgggaattggccctggag

13261 ctgtttacta tcagttcctg tccagcttca ctaaatttgg tctggggtcacatcttagct

13321 gcggactgtg gggttttgtg gtcccttctc gacttggccc agctccacctgaatcctgtt

13381 gttgtcaaat tgctgtaata ggatccagtt gatggacaga ctatccaatgaatccattat

13441 gttggtggtg gagctggtgc aaagagctcc agagcagctg ctggcactgacccccctcca

13501 ccaggcagcc ctggcagaga gggcactaca aaacctggta agagtccaccctaccagact

13561 cagatttgct gccctgggca attcttgctc ctcagacaat gctctctgactgtcccccaa

13621 ccctctactt cttgctttct tgctgccaaa cagattcctg tctacaaggcctggcccctg

13681 ttttgcctct gggttctgtt ccttgataat atgcttcacg ttacttgtccatacctcttg

13741 gagtccgaga aatctcttgg agtccacctc tcagtctttc tgcctgctcctatctgggct

13801 cattgcttaa ggaagtgaac aaaggtagtg agcatcatag ggtgctgagctgggagcagg

13861 agggagggaa ggttaggggg cttggtgtct tgatcaaggt gtctggtattctgagtcaga

13921 agtgcattgt ccaagttctg atgctcttct ccaggctcca aaggagactccagtctcagg

13981 ggaagtgctg gagaccttag gccctttggt tggattcctg gggacagagagcacacgaca

14041 gatcccccta cagatcctgc tgtcccatct cagtcagctg caaggcttctgcctaggaga

14101 gacatttgcc acagagctgg gatggctgct attgcaggag tctgttcttgggtatggacc

14161 ttcgagaact tcagattcta actcattcta tacccagtcc ctcagccaccatcatcagtg

14221 gcagcctgtt ccatattctt aaggtcccct ggagccctgt gtccgaaatcctagcatgtc

14281 ctcttttccc cttccttttc ctcacagttc cctcagctcc ccagcccccgattttcttcc

14341 tgtccccagg aaaccagagt tgtggagcca ggatgaagta gagcaagctggacgcctagt

14401 attcactctg tctactgagg caatttcctt gatccccagg gtgagatgaaggaagaaggg

14461 aagggagtaa atgcatagag gggactggtg agctggttat ggggacccgtggccaaagag

14521 ggcaaaggat atgaagccta gatctggggg gagactgcaa aacagagacaggactttgga

14581 cttagagcta tagcagcagg tcctgatctg tccagatctc cccactctccttctaccttc

14641 tcatgcagga ggccttgggt ccagagaccc tggagcggct tctagaaaagcagcagagct

14701 gggagcagag cagagttgga cagctgtgta gggagccaca gcttgctgccaagaaagcag

14761 ccctggtagc aggggtggtg cgaccagctg ctgaggatct tccaggtgaaactacccaaa

14821 tacttatatg tccagcagga tgtacaggga gtatcaaacg gtctgggttctacatgtgct

14881 cttccctggg actgggtttt ctaatttata aagcaaagag tttagagggatgatcttcaa

14941 gcctcttgta gttctagaat tctgtagttc tgggagtttg taaactattaagttttcttt

15001 tagcccagaa cttccatttt cctgctctct cgtgtctgct ctagactcagctctagctcg

15061 gctaagtgtg gagctctctg ctggggagat ccctagaagc tttgaaggagacattgtgag

15121 gctggagaac tgggttcaaa ttcagtgcta ccattaaatc tctgaataacatcctcagtc

15181 ttccatctat aaaagtcttg gcatctccaa tcacttcttg ttctattatctcctaagccc

15241 tatacatatt actctgtaat actcctttga tccctatttc tcacagtgctctatcctcca

15301 aaggttggaa gactcactct atctacagat atctctctgg gcatattttattactgcgct

15361 gacctcctgg ccctgccttc ccccttcaga acctgtgcca aattgtgcagatgtacgagg

15421 gacattccca gcagcctggt ctgcaaccca gattgcagag atggagctctcagactttga

15481 ggactgcctg acattatttg caggagaccc aggacttggg cctgaggaactgcgggcagc

15541 catgggcaaa gcaaaacagg ttagggatgg agagccaact ggggttggccatgaggaagc

15601 tatttgggtg tgatgtagga cacaaagaga atggagagtt ggatgagaggtgggggaagc

15661 aagagataga agagttagaa gatttgggtc acaagtagga ggtgaagggagataaatatt

15721 gaggaaagag agctagtata atgaatagag ggacgaaagc agtggttaccaaattttaat

15781 gcatatcacg atcatcaagg gaacagattt ttttctttat ttttttttctttcttaaaaa

15841 aataatggca tgcttcggct gggtgcagcg gctcacgcct ataatctcagaactttggga

15901 ggccaaggcg ggcagatcac gaggtcagga gatcaagacc atcctgtctaacacggcgaa

15961 acacggtctc tactaaaaat acaaaaaagt tagccgggca tggtggtgcacacttgttgt

16021 cccagctact tgggaggctg aggcaggaga atggcgtgaa cctgggagggggagcttgca

16081 gtgagccgaa gtcaagccaa tgcactccat cctgggtgac agagcaagactccatctcaa

16141 aaaaaaaaaa aaaaaaaaaa ggcatgcttc atgaatttgc gtgttatccttgcacaggcg

16201 ccatgcaaat ctctgtatca ttccaatttt ttggggtatg tgctgctgaactgagcatgg

16261 gaacagtgcc agtgccagat taccatgctt cactgactta ataaaaacctttggggaggc

16321 tgggcgcagt gactcatgcc tgtaatcaca gcactttggg aggcggaggcaggtggattg

16381 cttgagccca ggagttagag accagactgg gcaacatggt gaaaccctgtctctactaaa

16441 aatagaaaaa acattagctg ggtgtggcgg cacatgcctg taatcccagctactcaggag

16501 gctggggtag gagaatccca tgagtgcagg aggtggaggg tgcaatgtgccaagatcgca

16561 ccactgccct ccagcctggg tgtcagagca agaccctgtc tcataaattaaaaaataagc

16621 ctctggggga aagagtctag acatctgcat ctcctttttt tttttttttttttttttttg

16681 agacagagtc tcactctgtc acccagcatc caggctggag tgcagtggtgtgatcttggc

16741 tcactgtaac ctctacatcc tgggttcaaa cgatcctcct gcctcagcctctcaagtagc

16801 tgggactaca ggtgcaccac acctggctaa tttttgtatc tttggtagagatggggtttc

16861 actatgttgc ccaggatggt ctcgaacttc tgggctcaag caatcctcccacctcagcct

16921 cccaaagtgc tgggattaca gctgttagcc actgtgctgg gccctaggcatctgttttaa

16981 taagcgtctc tgtgtctgat gcacataaaa gtgtggaact catggactagagttagtttg

17041 ctcttctttt ccactgattg taatgtcttt caaaacacct tagaggaactgtaaggcaac

17101 ggtctcattt tatagtggag gaaactaaag aaaaggcaaa tgatttacctagagttatac

17161 agctaagggc agaggcaaga cttaaaaccc agcagtatga ctcccaatccactgcttttc

17221 cactcacatt gttcctgtct ttctcctagt tgtggggtcc cccccggggatttcgtcctg

17281 agcagatcct gcagcttggt aggctcttaa taggtctagg agatcgggaactacaggagc

17341 tgatcctagt ggactgggga gtgctgagca ccctggggca gatagatggctggagcacca

17401 ctcaggtaac acttttcctc ctccctacgg cttcccaaac acccatcccacagacccagc

17461 cctatagatc atctaaagcc caaggaattt ttttcctgtg accctacctggtccttcttt

17521 ctatcttttg ttgatacccc atactagtga ccttcaggac tctgatttattcactctgag

17581 gccctggaca cataatactg tctcctacct cttttcctgg aggcttcctctttttctttc

17641 cttttctttt ctgagtcctc agccttcccc atgactcctt aggtcttaatagtaacagaa

17701 tataacccag taacacctat cacttccctg tccattaatt ctccataactttcctccttc

17761 ccctcttctc ccacccccca ccccagctcc gcattgtggt ctccagtttcctacggcaga

17821 gtggtcggca tgtgagccac ctggacttcg ttcatctgac agcgctgggttatactctct

17881 gtggactgcg gccagaggag ctccagcaca tcagcagttg ggagttcaggtcatttgtga

17941 aggggctgag ggtggtggtg ctgaggtaaa ggtggactta ctggggaaagaaggatcatg

18001 aaggtctggt cccatggagg aagggaactc atttgaagcc atctcttcctttgtctcatg

18061 accacagccc ctttcactga agccgaattc ttcttccttc cttcctactgttctacagcc

18121 aagcagctct cttcctcggc accctgcatc tccagtgctc tgaggaacaactggaggttc

18181 tggcccacct acttgtactg cctggtgggt ttggcccaat cagtaactgggggcctgaga

18241 tcttcactga aattggcacc atagcaggtg gggagctggg ccactgctggtgcaagttgg

18301 tttggtttct ataccatggg tggactggat ggaagactgc cctgcaattcttaaggtggg

18361 ggcctgaggg tgtttaaata aggggctaga gacatattgg ggaaggtctatgatagggca

18421 ctttgggagt agttagagaa ggtctatagg tttgaagaga gggaaggtcagtctaagaca

18481 atgtttggat gccacttgct tcaacagctg ggatcccaga cctggctctttcagcactgc

18541 tgcggggaca gatccagggc gttactcctc ttgccatttc tgtcatccctcctcctaaat

18601 ttgctgtaag tattaatgga ctggggtgac cacaggagag ccagggcccaatggggacta

18661 catgcatgca ctgattccta cccctgccct caggtggtgt ttagtcccatccaactatct

18721 agtctcacca gtgctcaggc tgtggctgtc actcctgagc aaatggcctttctgagtcct

18781 gagcagcgac gagcagttgc atgggcccaa catgagggaa aggagagcccagaacagcaa

18841 ggtgagttcc cagctgcaca gcttgatcct ccatctcctg acccagaatcaaacccctaa

18901 tttggtgctg tctggctctt agagtgcacc cagggagatc cctggagtgaaggagtctac

18961 aggcagagcg ctaatttcca agtatcaatg ctcctggaga gctgagttgtgatattactc

19021 ccattccctg tctattatag gtcgaagtac agcctggggc ctccaggactggtcacgacc

19081 ttcctggtcc ctggtattga ctatcagctt ccttggccac ctgctatgagcctgtctcta

19141 cagtagaagg agattgtggg gagagaaatc ttaagtcata atgaataaagtgcaaacaga

19201 agtgcatcct gattattttc agaagctgat gaggaata

人STRC假基因的核苷酸序列示于SEQ ID NO:38。

人硬纤毛蛋白假基因1(STRCP1)(SEQ ID NO:38)

1 gccctgccct cacctggcta tcccacacag gtgagaataa ccagaactca cctccggtac

61 cagtgttcac ttggaaacat ggctctcagc ctctggcccc tgctgctgct gctgctgctg

121 ctgctgctgc tgtcctttgc aggtaagaag aacagtgagc agaactgggg atgaggagga

181 gggtggctgg aaaaagactt taagaatatg gaggtgaacc tgttagatag aaggacaaag

241 gagagaggca gagacttgtg caaaagggaa aaatgagggt taagaaaagc aggccaagac

301 ttactgtagg ccagtgaaag gggttcagct caccatcccc tcacctcatc tttagatcca

361 ggtagggaac tgtgctcagg ggcagggttg agtttgggct ctgtgttcct ctccttcagt

421 gacctctggt ttctctcctt acagtgactc tggcccctac tgggcctcat tccctggacc

481 ctggtctctc cttcctgaag tcattgctct ccactctgga ccaggctccc cagggctccc

541 tgagccgctc acggttcttt acattcctgg ccaacatttc ttcttccttt gagcctggga

601 gaatggggga aggaccagta ggagagcccc cacctctcca gccgcctgct ctgcggctcc

661 atgattttct agtgacactg agaggtagcc ccgactggga gccaatgcta gggctgctag

721 gggatatgct ggcactgctg ggacaggagc agactccccg agatttcctg gtgcaccagg

781 caggggtgct gggtggactt gtggaggtgc tgctgggagc cttagttcct gggggccccc

841 ctaccccaac tcagccccca tgcacccgtg atgggccgtc tgactgtgtc ctggctgctg

901 actggttgcc ttctctgctg ctgttgttag agggcacacg ctggcaagct ctggtgcagg

961 tgcagcccag tgtggacccc accaatgcca caggcctcga tgggagggag gcagctcctc

1021 actttttgca gggtctgttg ggtttgctta ccccaacagg ggagctaggctccaaggagg

1081 ctctttgggg cggtctgcta cgcacagtgg gggcccccct ctatgctgcctttcaggagg

1141 ggctgctccg tgtcactcac tccctgcagg atgaggtctt ctccattttggggcagccag

1201 agcctgatac caatgggcag tgccagggag gtgagtgtgg ccagggctgggactgggatg

1261 tggcagggca aggaaagtga aattggggta gttttcttcc ttactctttccctcctaggt

1321 aaccttcaac agctgctctt atggtaagta acaggagacc agttctgagggattgggcct

1381 ggaaaatctg gaggtgaaga gctgaagacc tcagcctcta gagaggaaaactgatgggag

1441 gagtgtagtt tagtggtttt ggggtgtgac tgtctgggtt ggtgtcccagctccacctct

1501 tcctagccat atgaccttga gcaggttaca tagtctttct atacctcagtttccccattt

1561 ataaaatgag aatgataata ttagttacca cagagttgtt gcacccggttaaatgagttg

1621 atactgtgta tgcaaacgac ttaaaaccgt gctggcacat agcgcttaataatgttagct

1681 agtaaagatg ggatttggaa aataaggaca cagctggatt cctctacccccttactactt

1741 cagtacaaca atgccagaca gtagttagac atattgagtt gctgagcagatttcctaaca

1801 tgaggcccgc tgagggttgt gtttaagcta tctaaaagca tatgaagaaaggagacagaa

1861 gggggccagg tggacagaaa gaattccaac tggggcttct cctaggtgattttggacctt

1921 ggcagggcag ctttctcttt tttgccccgt tgcagcattt caaccagtaacgcctaaact

1981 ctcagggacc tcgcttgtag aaaagcctat gcttgccatg ccccttgagggctctgagtc

2041 agggtcagaa tcttcagctg gaggaaatgt gaactgacca gatcctgcctgctcctccct

2101 ctgcacccag gggcgtccgg cacaaccttt cctgggatgt ccaggcgctgggctttctgt

2161 ctggatcacc acccccaccc cctgccctcc ttcactgcct gagcacgggcgtgcctctgc

2221 ccagagcttc tcagccgtca gcccacatca gcccacgcca acggcgagccatcactgtgg

2281 aggccctctg tgagaaccac ttaggcccag caccacccta cagcatttccaacttctcca

2341 tccacttgct ctgccagcac accaagcctg ccactccaca gccccatcccagcaccactg

2401 ccatctgcca gacagctgtg tggtatgcag tgtcctgggc accaggtgcccaaggctggc

2461 tacaggcctg ccacgaccag tttcctgatg agtttttgga tgcgatctgcagtaacctct

2521 ccttttcagc cctgtctggc tccaaccgcc gcctggtgaa gcggctctgtgctggcctgc

2581 tcccaccccc taccagctgc cctgaaggcc tgccccctgt tcccctcaccccagacatct

2641 tttggggctg cttcttggag aatgagactc tgtgggctga gcgactgtgtggggaggcaa

2701 gtctacaggc tgtgcccccc agcaaccagg cttgggtcca gcatgtgtgccagggcccca

2761 ccccagatgt cactgcctcc ccaccatgcc acattggacc ctgtggggaacgctgcccgg

2821 atgggggcag cttcctggtg atggtctgtg ccaatgacac catgtatgaggtcctggtgc

2881 ccttctggcc ttggctagca ggccaatgca ggataagtcg tgggggcaatgacacttgct

2941 tcctagaagg gctgctgggc ccccttctgc cctctctgcc accactgggaccatccccac

3001 tctgtctgac ccctggcccc ttcctccttg gcatgctatc ccagttgccacgctgtcagt

3061 cctctgtccc agctcttgct caccccacac gcctacacta tctcctccgcctgctgacct

3121 tcctcttggg tccaggggct gggggcgctg aggcccaggg gatgctgggtcgggccctac

3181 tgctctccag tctcccagac aactgctcct tctgggatgc ctttcgcccagagggccggc

3241 gcagtgtgct acggacgatt ggggaatacc tggaacaaga tgaggagcagccaaccccat

3301 caggctttga acccactgtc aaccccagct ctggtataag caagatggagctgctggcct

3361 gctttagtgt gagtgctctg ccagagggaa agctcctaga acagtgagaaggccctccag

3421 gggaattcct cgaatactca gaggcagtag tgtggggtag tagttgaagcacacagctct

3481 agagtcagac aggcttggat tcatatcttg gttctgtgac cagccttgaatgagttattt

3541 aacttctctg agcaatattt ttctcgtctc atttataaac tagggatgataatggtatat

3601 gagataatac atgctgtggg cttagcacag tgcatgatac acaaacatgcaataaatatt

3661 accttgttat tcttttgggc tctttgactc tctcactttc tgcaccagaaagaaaaagga

3721 tcaagttaga ggactctaaa tttttcccct agagagtgag aattggaggctggcagaata

3781 caggaagata aggtaggaat gagaaagatt cagggacact accaatcagaagactttggt

3841 tctaggttca actgtgccac aaattagtgt gatcttaggc aagcaatttcatttagtttt

3901 tctgggcttc agtttttagt ctgtagaatg gaggggtgag aatatgttaaacaccataat

3961 taattcactg agtgcctatt atatgcaagg cactttgcta ggttctgtaggatatataaa

4021 gatttcttac tccatgttgg ggccaccttt ttcaaaccct gggcccagtaaaatggaatt

4081 agatagtctc atagtatttg gttcaggtct acaagtatta attgagccaactatggacct

4141 ggcatgggag agggtacaag agaaattaga gatatgatcc cggacctaaaagagcttaat

4201 atctgaagaa tcacacttga gatgatggac aagcatccca gcaagtggagttggaatgcc

4261 tgggggagct gcaggagaga cagagaagac agctctgttg gcatattgtctttcttccca

4321 ccagcctgtg ctgtgggatc tgctccagag ggaaaagagt gtttgggccctgcagattct

4381 agtgcaggta acaggtggag ggcacatggg tgggctgggt gacagccatggctggaggtc

4441 cctgccccgt gaggtgaggc catacccacc atgacctcct attcgcaggcgtacctgcat

4501 atgcccccag aaaacctcca gcagctggtg ctttcagcag agagggaggctgcacagggc

4561 ttcctgacac tcatgctgca ggggaagctg caggggaagc tgcaggtgagcactgagaaa

4621 ggggagcaag ggcacctgga gcctagtgtt cagagggctt gctttagtgggaggaggaac

4681 tccagagagg aaatggcagg gatactgagc atctccagag gcagaatccattcctgtgcc

4741 cctacaggta ccaccatccg aggagcaggc cctgggtcgc ctgacagccctgctgctcca

4801 gcggtaccca cgcctcacct cccagctctt cattgacctg tcaccactcatccctttctt

4861 ggctgtctct gacctgatgc gcttcccacc atccctgtta gccaacgacagtgtgtaagg

4921 ttcttgcact actcctcctg ctcctgtcac ggtcaggcca accgcatccacctggagcag

4981 ccccttccgg agctcctctc tgtttttttc tttcatgcca gataggcaatgtgccaacat

5041 cgtagcaagg tttgagagag gcacatctca cgcctgagtg tgaaaacccaatcattatgc

5101 taatgaacta caaaaggatc agagagctcc tctctattaa aaccagggagaggatgggcg

5161 tggtggctca tgcctgtaat cccagcacgt tgggagcccg aggcaggtggatcactaggt

5221 ccgcctagtg agttcgagac cagcctggcc aatatggtga aaccctgtctctattaaact

5281 acaaaaatta gccaggcatg gtggtgggcg cttgtagtcc cagttactctggaggctgag

5341 gcaggaggat agcttgaacc tgggaggcag aggttgcagt gagccaagatcgtgccactg

5401 cactccagcc tgggtgacag agcgagactc cgtcttaaaa aaaacaaaaaacaaaacaaa

5461 acaaaaaaac agggagagtc tccttcctat ctagacagca gggctacagagggtcagagg

5521 aaaacagttt ggaggaagac aaagggttaa gacccatgac tcctcgcagcctggctgcca

5581 tccgggatta cagcccagga atgaggcctg aacagaagga ggctctggcaaagcgactgc

5641 tggcccctga actgtttggg gaagtgcctg cctggcccca ggagctgctgtgggcagtgc

5701 tgcccctgct cccccacctc cctctggaga actttttgca gctcagccctcaccaggtat

5761 gagaatcatc ttctttactt gactggccca tcttctgcta gtggggacaaagagtcaatg

5821 gcatgtctct cagtggcccc tccctgcaag aaccctatag tgaccccagtgcgagctaac

5881 cttccccatc tcagatccag gccctggagg atagctggcc agcagcaggtctggggccag

5941 ggcatgcccg ccatgtgctg cgcagcctgg taaaccagag tgtccaggatggtgaggagc

6001 aggtacgcag gtgagttgtt gtgggatcag taaccaaggc aagagtggaagaggtagaga

6061 gaggaaggca cagctgtcac gctgggtcgg tgttctagga agaaaggggcaagagagtag

6121 gcagtggcct caggcagcat agagttccag gagagaggtc tatagatggtgcccctgtgt

6181 agtggtgtag tgtcagagtg cccagtgtat gtacccatac catctgctgccaggcctgcc

6241 ttagtgctag tcttggggac cacacaaagg tcagcttcat gccctcctcaggcttgggcc

6301 cctcgcctgt ttcctgagcc ctgaggagct gcagagccta gtgcccctgagtgatccaac

6361 ggggccagta gaacgggggc tgctggaatg tgcagccaat gggaccctcagcccagaagg

6421 acgggtgagc ccctcagcac aagcctacaa gactttaggc ttcccctgggtctgtgtgga

6481 tggctttccc attgtgtcaa cttgagcaca gtggtgccag cccccatcccacttttgcaa

6541 cctccattcc ttactccatg gccattctta cctgttacca cctcttcctggcccttctct

6601 atctggtctg tagcacccca aacataccct ttgccatttt gaacctaatctactccagtc

6661 caatccctag ttccaaaccc tagcccaggc cctgggaaat tcagatgtgggattagagag

6721 gaagttcaag gttcatctgt cttttctctc cagtcctaaa ccttctttggttacaggtgg

6781 catatgaact tctgggtgtg ttgcgctcat ctggaggagc ggtgctgagcccccgggagc

6841 tgcgggtctg ggcccctctc ttctctcagc tgggcctccg cttccttcaggagctgtcag

6901 agccccagct tagagccatg cttcctgtcc tgcagggaac tagtgttacacctgctcagg

6961 tttgcctgtc tcactccctg gcatgtaccc tccatccccg cttgagccccagtcaagaga

7021 atcccattca gggataaaag cagcccctcc tttccctggg tgaacagtagaggtaaactc

7081 tgtctgcagg aggacgcctt cattcccttt cctcagatca agaagggacctgagtcactg

7141 aggatggtta ctggggatgg ttaagaggca gcgggaagtt ttggagggtttgccttagga

7201 acccacttag gacctggctg ctgggtcctg agagctgttg ttttcggtcccatcccaaca

7261 caggctgtcc tgctgcttgg acggctcctt cctaggcacg atgtgagtagcagcaacttc

7321 tcagcctccc gccagaggtc tctatcctct tttaacctgg ctcctgcatctgcccctcct

7381 ctctctccgc tcccctcata cttactgcct tgctgcattg tgattgttgtcttccccaac

7441 acccttccct tcttcttcag gcctcttgtc tctcttgctc tttagctatccctggaggaa

7501 ctctgctcct tgcaccttct gctaccaggc ctcagccccc agacactccaggccatccct

7561 aggcgagtcc tggtcggggc ttgttcctgc ctggcccctg aactgtcacgcctctcagcc

7621 tgccagaccg cagcactgct gcagaccttt cgggtatgag agtggcaaggaggatgagat

7681 aatcagggat accggctctt tctggttggg aggaaggcat cttccctgaggccagggaag

7741 gcctttcata cctccccact tacacacaca cacacacaca cacacacacaaccaattctc

7801 atgcaggtta aagatggtgt taaaaatatg ggtacaacag gtgctggtccagctgtgtgc

7861 atccctggtc aggtaagtgt gagatctccc aactgagctc ctctccccattctggggcag

7921 tttcatatgg ctggtgctac ctcccacact accctgcagt ggccctgagagttctggtta

7981 gctctgtgcc cattagcagc cctccccagt gccagatgca ggacagcatgatccactcac

8041 attgtcctag actaatgtca aagctggaag ggcctgagaa atcttccaggccacccaccc

8101 tgctttcaga tgaaaagacc aaggctggga gaagctaagg gactttgtttgcctggtgcc

8161 taactagcag caacacttga ccacagcagc ctgcagtgtg aggctcttaggcgtttattg

8221 ctacagtggc aaatgccatt ccacttctgt cctagctttg gtccctttccacccccatgg

8281 ttccttttct ctgagtgcta agtacagact ctctcaccta tcactacactgctataccca

8341 tcaccgccag cagcctattc ccaccacctg gccagactgc ctgcttcccctgctcccatt

8401 aaagctgcta caactggatt ccttggctct tctggcaaat cgaagacgctactgggagct

8461 gccctggtct gagcagcagg taattctccc cacttaattt cagaacttcctccctcaatg

8521 tagtctacct tctttaccta tcccttagcc ctatttggcc agcttatccctactatcctt

8581 tatttgattg tttgagatac agtctcactc tgttgcccag gctgcagtgcagtggcatga

8641 tcagagttcg ctgtaacctc aaactcatga gctcaggcaa tctttctgcctcagcctcct

8701 gaatagctag gatgacaggt ggttaccacc atgcctggct aatttttaaatttttttttt

8761 gttttttgag atgaagtctt gctctgtcac ccaggcttga gtacagtggcacaagcttgg

8821 ctcactgcaa cctctgtctc ccgggttcaa gcgattctcc tgcctcagcctcccgagtag

8881 ctgggactac aggcactccc cacaatgccc ggctaatttt ttttttgttttagtagagac

8941 agggtttcac catattggcc aggctggtct cgaactgctg accttgtgatctgcctgcct

9001 ctgcctctca aagtgctggg attacaggtg tgagccacca tgcccggccaatttttaaat

9061 tttttgtaga gacagacaat acaaaaatgt ggacactatg tggagacactatgttgaggt

9121 actatgctgt ccagattggt cttgaactcc tggcctcaag caatcctcctgccttggcct

9181 cccaaagtgc tgggattaca gacctgagcc actgcaccca gccccctagtatcccttata

9241 atgtgacttg cttttctttt tctttctcct tcccttttct ttcatttctttctcactctc

9301 gagagaagag tgggcatctg ggagagtggg aggctggtgg gtcccacagagtgaggaggc

9361 aggactgggt ccaaggcagt cctgcctctc cactctaggg ggtatccttggacagtgtct

9421 cttctgggaa ggggctcgtc tttctttctc ttgtaggcac agtttctctggaagaagatg

9481 caagtaccca ccaacctgac cctcaggaat ctacagtgag taacttgtgttgagcagtgc

9541 gctgaattcg accaacattt ttttgagtgc ttactatgtg ccaggcaccatatgatatgg

9601 aatgggggat atagggatga atgatgcata gtccctgcct cgtggacgttctcctagcac

9661 ctccctttgc cctcctttcc ttccacagtg ccatgcctat cctgactagagccaaaggac

9721 tcagaaaacc tggattcagg ttccagtcct gtcacctact tgtcctcttgggcaagtcat

9781 ttaacgtccc tgtgtcagtt ttcccttctt taaatgagaa ttacaatggcaccagcctca

9841 taggtagtta ctgtgaagat taaatgaggt aggtcatgta agatatttaacacagtgttt

9901 ggtccattgt aaagttccag tagtcatttg ctactgttag tttacttcaggatgacttca

9961 gaggcactgg ccaagcaaga ataaatagga ataagaaggt atcactttacttatacccac

10021 attagaagaa caatgggctt cagaatcttt tttttttttt ttttcgagacagtcttgctc

10081 tgttgcccag gctggagtgc agtggcgcga tttcggctca ctgcaacctctgcctcccag

10141 gttcaagcga ttctcctgtc tcagcctctg gagtagctgg gattacaggaatgtgccacc

10201 atacccagct aatttttgta tttttagtag agatggggtt tcaccattttggccaggctg

10261 gtctcaaact cctgacctca ggtgatccac ccgcctcagc ctcccaagggcttcagaatc

10321 taagacatgt ctctagtttc agtttaccac atttctagca gaatgatgttgggaatgtca

10381 cctgacttcc ataaatcctt attttctcct ctgataaaca gcagtgatgttatggggagc

10441 tgatgagata tctatgtaaa aacatttctc aaaccataaa ttacggtggatgaacatctg

10501 tacttgtgtt gagagtactg atatcaagga gcaaacaggc tgttgtatgtgttgaatgag

10561 cctctcccca ctcacacacc cacagggctc tgggcaccct ggcaggaggcatgtcctgtg

10621 agtttctgca gcagatcaac tccatggtag acttccttga agtggtgcacatgatctatc

10681 agctgcccac tagagttcga gggagcctgg tgagagggga tgcctggactttagtgggag

10741 cagggaggct gggaccctag gtatagaacc cagctcctat gttctgctctggcctcactc

10801 tgcttcccta cagagggcct gtatctgggc agagctacag cggaggatggcaatgccaga

10861 accagaatgg acaactgtag ggccagaact gaacgggctg gatagcaagctactcctgga

10921 cttaccgtaa gtactgcagc tagagatatt ggcccctcag aaagctcaatctggggtgaa

10981 gatctgccct tagggaatgc cctggaggag gtagtttttc tgtctggtagttccctgaca

11041 taatttatag cccaaagcag aggattttat tcaaagttgc tctatgtattgactggttcc

11101 cagaatatgc tccagcacag ggcagctgag ggtggcaaca ctgtattgaagcctgccaag

11161 taatcttaca ataacctagt ccacattaat tgagattgag acagagcatctgaagtgagg

11221 gaggcaatgc tccaaatctg ccccagagga ttgtagtttg ctcagggcactgtgttctta

11281 gtgcattcag aggagtggat cgagagaaaa atatatgaaa aatgtgataaataccttcaa

11341 atacctgagg ggctatcaag tagaaattag attgtcatat ttatgagtggccccattggg

11401 caagactaag agtagttaac ggagatcaga tttttacata gtataagaaaaactaaggta

11461 gtgagttcct ggtccttgga gctgttcgag cctaagccag atggccccatggcaggaatg

11521 ttgtagagca cgttcatata caggttgtgg gaagaaaagg ctataggaacccaaggctcc

11581 tccctaccca tggagaaatt tattagtatg ttactcatat gctgcttttctcattttacc

11641 cctaccacca ccccgttgcc atccgcactg taagtcagga taggaaaatgctggtgttac

11701 agtcttcctg gggaatatgg agctgaagtg gagtaaaagc agttgacttcattcttactt

11761 ttttcttttt cttttttttt ttttttttga gacagagttt tgctgtgtcaccaaggctgg

11821 agtgcagtga cgtgatctcg gctcactgca acctccatct tccaggttcaagcaattctc

11881 ctgcctcagt ctcccgagta gctgggactg taggtgtgca ccaccatgccaggctaattt

11941 ttgtatttgt tgtagggacg agctttcacc atgttggcca ggctggtcttgaactcctgg

12001 cttcaagtga tctgcccacc tcggcttccc aacattctta tatttttataggcctttcca

12061 cagatttcag ctcttgtatg acttagccca gttccagaac tggtaatcctaggtagggta

12121 caggttatca cctctgattt cgggtaaaag ggatttattt atttatttgtttatttattt

12181 atatttttga gacagagtct cgctctgtca cccaggctgg agtgcaatggtgccatctcg

12241 gctcactgca acctctccct ctggggttca agcacttctg cctcagcctcctgagtagct

12301 gggattacag gcgcgtgcca ccacacccgg ctaatttttg catttttagtagagacgggg

12361 tttcaccatg ttgctcaggg tggtctcgaa tttctgaccc tgtgatctgcctgcctcggc

12421 ctcccaaagt gctgggatta caggcatgag ccactgcgtc cggcctgtttttactttttt

12481 ttaatgccat tcagatctgt ttaaatatgt gggttctgtg agataatttagaatcccaag

12541 gttacagatg aggtgaaaga tcctagacca tgcatcaaaa aacttgagtttctcatttgt

12601 gaaagaagga taagagaaac acctattttg tctgggtgca gtggctcatgcctataatcc

12661 cagcatttgg ggaggccaag gtgggtggat cacggaggtc aggtgttcaagaccagactg

12721 gccaacatgg caaaacacca tctctactaa aaatacaaaa gttagctgggcgtggtggca

12781 cgtgcgtgta attccagcta ttcgggaggc tgaggcacga gaattgcttgaacctgggag

12841 gtgcgggttg cagtgaactg agatcgcagc accactgtgc tccagcctgagtgatggagt

12901 gaggccaggt cttgttgtag gatcaaatga gataacacct gaaagaactttgtaaattgt

12961 atagcacgta caaacaagaa gggacctctt cacaagcaga ggaagggtggtcctgtggaa

13021 aaaaacggga attgggagtg agagacctca acatttgatc tctgtgaacctcagtttttt

13081 aatctataaa atggggaaat gttaatggta cttaatattt ggagcttttgagtccattag

13141 atcaggtagg attgttcgtt attttttttt tttaggaaga ctagaaatatgttgctccct

13201 ttttctcccc cactcaagct tgatggtggg aattggccct ggagctgtttactgtcagtt

13261 cctgtccagc ttcactaaat ttggtctggg gtcacatctt agctggggactgtggggttc

13321 tgtggtccct tctcgacttg gcccagctcc acttgaatga tattgttgtcaaattgctat

13381 aatagaatcc agttgatgga cagactatcc aatgaatcca ttatgttggtggtggagctg

13441 gtgcaaagag ctccagagca gctgctggca ctgacccccc tccaccaggcagccctggca

13501 gagagggcac tacaaaacct ggtaagagtc caccctacca gactcagatttgctgccctg

13561 ggcaattctt gctcctcaga caatgctctc tgactgtcct ccaaccctctacttcttgct

13621 ttcttgctgc caaacaggtt cctgtctaca aggcctggcc cgttttgcctctgggttctg

13681 ttccttgata atatgcttca cgttacttgt ccatacctct tggagtccgagaaatctctt

13741 ggagtccacc tctcagtctt tctgcctgct cctatctggt ctcattgcttaagaaagtga

13801 acaaaggtag tgagcatcat agggtgctga gttgggagca ggagggagggaaggtcaggg

13861 ggcttggtgt cttgatcaag gtgtctggta ttctgagtca gaagtgcattgtccaagttc

13921 tgatgctctt ctccaggctc caaaggagac tccagtctca ggggaagtgctggagacctt

13981 aggccctttg gttggattcc tggggacaga gagcacacga cagatccccctacagatcct

14041 gctgtcccat ctcagtcagc tgtaaggctt ctgcctagga gagacatttgccacagagct

14101 gggatggctg ctattgcagg agtctgttct tgggtatgga tcttcgagaacttcagattc

14161 taactcattc tatacccagt ccctcagcca ccatcatcag tggcagcctgttccatattc

14221 ctaagggccc ttggagccct gtgtccgaaa tcctagcatg tcctcttttccccttccttt

14281 tcctcacagt tccctcagct ccccagcccc cgattttctt cctgtccccaggaaaccaga

14341 gttgtggagc caggatgaag tagagcaagc tggacgccta gtattcactctgtctactga

14401 ggcaatttcc ttgatcccca gggtgagatg aaggaagaag ggaagggagtaaatgcatag

14461 aggggactgg tgagctggtt atggggaccc gtggccaacg agggcaaaggatatgaagcc

14521 tagatctggg gggatactgc gaaacagaga caggactttg gacttatagctatagcagca

14581 ggtcctgatc tgtccagatc tccccactct ccttctacct tctcatgcaggaggccttgg

14641 gtccagagac cctggagcgg cttctagaaa agcagcagag ctgggagcagagcagagttg

14701 gacagctgtg tagggggcca cagcttgctg ccaagaaagc agccctggtagcaggggtgg

14761 tgcgaccagc tgctgaggat cttccaggtg aaactaccca aatacttatatgtccagcag

14821 gatgtacagg gagtatcaaa cggtctgggt tctacatgtg cttttctctgggactgggtt

14881 ttctaattta taaagcaaag agtttagagg gatgatcttc aagtctcgtctagttctaaa

14941 attctatagc tctgggagtg tgtaaactat taagttttcc tttagcccagaacttccatt

15001 ttcctgctgt cttgtctctt taaacagctg actcagctct agctcggctaagtgtggagc

15061 tctctgctgg ggagatccct cgaaggagac attgtgaggc tagagaactggtttcaaatt

15121 cagctctgcc atgaaatccc tgaccaacat cctcagtctt ccatctataaaatgagggac

15181 ttggcatctc caatcacttc ttgttcaatt cacttctaag ccctatacatcttaacctgt

15241 aatactccct cgatccctac ttcccacagt gctccatcct ccaaaggttggaagagtcat

15301 tccatctaca gatacctcct ggccctgcct tcccccttca gaacctgtgccaaattgtgc

15361 agatgtacga gggacattcc cagcagcctg ctctgcaacc cagattgctgagatggagct

15421 ctcagacttt aaggactgcc tgacactatt tgcaggagac ccaggacttgggcctgagga

15481 accacgggca gccatgggca aagcaaaatg ggtcagggac ggagagccaactgaggttgg

15541 ccatgaggaa gctgtgtggg tgtgatgtag gacacgaaga gaatagagagttggatgaga

15601 ggtgggggaa gcagaagata aaagagttag aagatttggg tcacaagtagaaggtgagga

15661 gagataaata ttgaggaaag agagctacta taatgaatag agggactaaagcagtgatta

15721 ccaaatttta atgcatatca caatcatcaa gggaacagat ttttttcttttttctttttt

15781 tttctttctt aaaaaataat ggcatacttc atgaatttgt gtgttatccttgcgcaggcg

15841 ccatgctaat ctctgtatca ttccaatttt tttttgtata tgtgctgctgaaccgagcac

15901 gggaacagtg ccaatgctgg attaccatgc tagactgact taataaaaacctttgcggag

15961 gctggacgga gtggctcgtg cctgtaatca cagcactttg ggaggctgaggcaggtggat

16021 tgcttgagcc caggagtttg agaccagact gggcaacatg gtgaagccctgtctctacta

16081 aaaatagaaa aaaaattagc tgggtgtggc ggcacatgcc tgtaatcccagctactcagg

16141 aggctggggt aggagaatcc cctgagcgca ggaggtggag ggtgcaatgagccaagatca

16201 caccactgca ctccagcctg ggtgtcagag caagaccctg tctcataaattaaaaaataa

16261 gcctctggga gaaagtctag acatctgcat ctgctttttt ttttttttttttttttgaga

16321 cacagtctca ctctgtcacc cagcatccag gctggagtgc ggtggtgtgatcttggctca

16381 ctgtaacctc tacatcctgg gctcaaacga tcctcctgcc tcagcctctcgagaagctgg

16441 gactacaggt gcacaccact acacctggct aatttttgta tttttggtagagatgaggtt

16501 tcgctgtgtt gcccaggatg gtcttgaact cctgggctca agcattcctcccacctcagc

16561 ctcccaaagt gctgggatta cagctgtgag ccactgtgct gggccccaggcatctgcatt

16621 ttaataagcg tctctgtgtc tgatgcacat aaaagtgtgg aactcatggactagagttag

16681 tttgctcttc ttttccactg attgtaatgt ctttcaaaac accttagaggaactgtaagg

16741 caacggtctc attttatagt ggaggaaacc aaagaaaagg caagtgacttgcctagagtt

16801 atacagctaa ggtcagaggc aagacttaaa acccagcatt ctgactcccaatctactggt

16861 tttccactca cattgttcct ctctttctcc tagttgtggg gtcccccccggggatttggt

16921 cctgagcaga tcctgcagct cggtagactc ttaataggtc tgggagatcaggaactacag

16981 gagctgatcc tagtggactg gggagtgctg agcaccctgg ggcagatagatggctggagc

17041 tccactcagg taacactttt actcctccct accgcttccc aaacacccatcccacagacc

17101 cagccctata gatcatctaa agcccaagga attttttcct gtgaccctacctggtcattc

17161 tttctgtctt ttgttaatat cccatactag tgaccttcag gactcttgatttattcactc

17221 tgaggccctg gacacataat actgtctcct acctcttttc ctggaggcttcctctttttc

17281 tttccttttc ttttctgagt cctcagcctt ccccatgact ccttaggtcttaatagtaac

17341 agaatataac ccagtaacac ctatcacttc cctgtccatt aattctccataactttcctc

17401 cttcccctct tctcccaccc cccaccccag ctccgcattg tggtctccagtttcctacgg

17461 cagagtggtc ggcatgtgag ccacctggac ttcgttcatc tgacagcgctgggttatact

17521 ctctgtggac tgcggccaga ggagctccag cacatcagca gttgggagtttaggtcattt

17581 gtgaaggggc tgagggtggt cgtgttcagg taaaggtgga cttgctggggaaaggaggat

17641 catgaagtta tagtcccatg gaggaaggga actcatttga agccatctcttcctttgtct

17701 catgaccaca gtccctttca ctgaagccga attcttcttc cttccttcccactgttctac

17761 agccaagcag ctctcttcct gggcaccctg catctgcagt gctctgaggaacaactggag

17821 tttctggccc acctctttgt actgcctggt gggtttggcc caatcagtaactgggggcct

17881 gagatcttca ctgaaattgg caccatagca ggtggggagc tgggccactgctggtgcaag

17941 ttggtttggt ttctatacca tgggtggact ggatggaaga ctgccctgcaattcttcagg

18001 tgtgggcctg agagggtgtt taaataaggg gctagagaca tattggggaaggtctatgat

18061 agggcacttt gggagtagtt agagaaggtc tataggtttg aagagagggaaggtcagtct

18121 aagacaatgt ttggatgcca cttgcttcaa cagctgggat cccagacctggctctttcag

18181 cactgctgcg gggacagatc cagggcgtta ctcctcttgc catttctgtcatccctcctc

18241 ctaaatttgc tgtaagtatt aatggactgg ggtgaccaca ggagagccagggcccaatgg

18301 ggactacatg catgcactga ttcctacccc tgccctcagg tggtgtttagtcccatccaa

18361 ctatctagtc tcgccagtgc tcaggctgtg gctgtcactc ctgagcaaatggcctttctg

18421 agtcctgagc agcgacgagc agttgcatgg gcccaacatg agggaaaggagagcccagaa

18481 cagcaaggtg agttcccagc tgcacagctt gatcctccat ctcctgacccagaatcaaac

18541 ccctaatttg gtgctgtctg gctcttagag tgcacccagg gagatccctggagtgaagga

18601 gtctacaggc agagcgctaa tttccaagta tcaatgctcc tggagagctgagttgtgata

18661 ttactcccat tccctgtcta ttataggtcg aagtacagcc tggggcctccaggactggtc

18721 acgaccttcc tggtccctgg tattgactat cagcttcctt ggccacctgctatgagcctg

18781 tctctacagt agaaggagat tgtggggaga gaaatcttaa gtcataatgaataaagtgca

18841 aacagaagtg catcctgatt attttcagaa gctgatgagg aata

Clarin 1(CLRN1)

CLRN1基因编码“clarin 1”(CLRN1)(一种在内耳的毛细胞(例如，内耳毛细胞、外耳毛细胞)和视网膜中表达的蛋白质)。

人CLRN1基因位于染色体3q25.1上。其包含7个外显子，涵盖约47千碱基(kb)(Vastinsalo等人(2011)Eur J Hum Genet 19(1):30-35；NCBI登录号NG_009168.1)。

CLRN1基因中的各种突变与III型Usher综合征(例如，IIIA型Usher综合征(MIM#606397))(参见，例如，Fields等人(2002)Am J Hum Genet 71:607-617和Joensuu等人(2001)Am J Hum Genet 69:673-684)和色素性视网膜炎(参见，例如，Khan等人(2011)Ophthalmology 118:1444-1448)相关联。主要在CLRN1的外显子3中发现了导致III型Usher综合征的突变。可通过产生CLRN1缺陷型小鼠来对III型Usher综合征耳聋进行建模(参见，例如，Geng等人(2017)Sci Rep 7(1):13480)。与III型Usher综合征相关联的示例性突变CLRN1包括：T528G、M120K、M44K、N48K和C40G。

与色素性视网膜炎相关联的示例性突变CLRN1包括L154W和P31L(参见，例如，Khan等人(2011)Ophthalmology 118:1444-1448).。

在患有听力损失的受试者中检测到的CLRN1基因中的其它示例性突变以及编码CLRN1的核酸的测序方法描述于例如Fields等人(2002)Am J Hum Genet 71:607-617、Joensuu等人(2001)Am J Hum Genet 69:673-684、Adato等人(2002)Europ J Hum Genet10:339-350、Aller等人(2004),Clin Genet 66:525-529中。检测基因中的突变的方法是本领域公知的。此类技术的非限制性实例包括：实时聚合酶链式反应(RT-PCR)、PCR、测序、Southern印迹和Northern印迹。

示例性人野生型CLRN1蛋白为或包括SEQ ID NO:39、SEQ ID NO:41、SEQ ID NO:43和SEQ ID NO:45的序列。编码野生型CLRN1蛋白的核苷酸序列的非限制性实例为或包括SEQID NO:40、SEQ ID NO:42、SEQ ID NO:44和SEQ ID NO:46。

在本文所述的任何组合物的一些实施方案中，所述CLRN1蛋白包含与SEQ ID NO:39具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。

在本文所述的任何组合物的一些实施方案中，所述CLRN1蛋白包含与SEQ ID NO:41具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。

在本文所述的任何组合物的一些实施方案中，所述CLRN1蛋白包含与SEQ ID NO:43具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。

在本文所述的任何组合物的一些实施方案中，所述CLRN1蛋白包含与SEQ ID NO:45具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。

人全长野生型CLRN1蛋白异型体D(SEQ ID NO:39)

MPSQQKKIIFCMAGVFSFACALGVVTALGTPLWIKATVLCKTGALLVNASGQELDKFMGEMQYGLFHGEGVRQCGLGARPFRFSFFPDLLKAIPVSIHVNVILFSAILIVLTMVGTAFFMYNAFGKPFETLHGPLGLYLLSFISVALWLPATRHQAQGSCGCLVMILFASEVKIHHLSEKIANYKEGTYVYKTQSEKYTTSFWVIFFCFFVHFLNGLLIRLAGFQFPFAKSKDAETTNVAADLMY

人野生型CLRN1异型体D cDNA(SEQ ID NO:40)

atgccaagccaacagaagaaaatcattttttgcatggccggagtgttcagttttgcatgtgccctcggagttgtgacagccttggggacaccgttgtggatcaaagccactgtcctctgcaaaacgggagctctgctcgtcaatgcctcagggcaggagctggacaagtttatgggtgaaatgcagtacgggcttttccacggagagggtgtgaggcagtgtgggttgggagcaaggccctttcggttctcattttttccagatttgctcaaagcaatcccagtgagcatccacgtcaatgtcattctcttctctgccatccttattgtgttaaccatggtggggacagccttcttcatgtacaatgcttttggaaaaccttttgaaactctgcatggtcccctagggctgtaccttttgagcttcatttcagttgccctttggctgccagctaccaggcaccaggctcaaggctcctgtggctgtcttgtcatgatattgtttgcctctgaagtgaaaatccatcacctctcagaaaaaattgcaaattataaagaagggacttatgtctacaaaacgcaaagtgaaaaatataccacctcattctgggtcattttcttttgcttttttgttcattttctgaatgggctcctaatacgacttgctggatttcagttcccttttgcaaaatctaaagacgcagaaacaactaatgtagctgcagatctaatgtactga

人全长野生型CLRN1蛋白异型体A(SEQ ID NO:41)

MPSQQKKIIFCMAGVFSFACALGVVTALGTPLWIKATVLCKTGALLVNASGQELDKFMGEMQYGLFHGEGVRQCGLGARPFRFSFFPDLLKAIPVSIHVNVILFSAILIVLTMVGTAFFMYNAFGKPFETLHGPLGLYLLSFISGSCGCLVMILFASEVKIHHLSEKIANYKEGTYVYKTQSEKYTTSFWVIFFCFFVHFLNGLLIRLAGFQFPFAKSKDAETTNVAADLMY

人野生型CLRN1异型体A cDNA(SEQ ID NO:42)

atgccaagccaacagaagaaaatcattttttgcatggccggagtgttcagttttgcatgtgccctcggagttgtgacagccttggggacaccgttgtggatcaaagccactgtcctctgcaaaacgggagctctgctcgtcaatgcctcagggcaggagctggacaagtttatgggtgaaatgcagtacgggcttttccacggagagggtgtgaggcagtgtgggttgggagcaaggccctttcggttctcattttttccagatttgctcaaagcaatcccagtgagcatccacgtcaatgtcattctcttctctgccatccttattgtgttaaccatggtggggacagccttcttcatgtacaatgcttttggaaaaccttttgaaactctgcatggtcccctagggctgtaccttttgagcttcatttcaggctcctgtggctgtcttgtcatgatattgtttgcctctgaagtgaaaatccatcacctctcagaaaaaattgcaaattataaagaagggacttatgtctacaaaacgcaaagtgaaaaatataccacctcattctgggtcattttcttttgcttttttgttcattttctgaatgggctcctaatacgacttgctggatttcagttcccttttgcaaaatctaaagacgcagaaacaactaatgtagctgcagatctaatgtactga

人全长野生型CLRN1蛋白异型体C(SEQ ID NO:43)

MQALQQQPVFPDLLKAIPVSIHVNVILFSAILIVLTMVGTAFFMYNAFGKPFETLHGPLGLYLLSFISGSCGCLVMILFASEVKIHHLSEKIANYKEGTYVY KTQSEKYTTSFWLTKGHS

人野生型CLRN1异型体C cDNA(SEQ ID NO:44)

atgcaggccctgcagcagcaaccagtttttccagatttgctcaaagcaatcccagtgagcatccacgtcaatgtcattctcttctctgccatccttattgtgttaaccatggtggggacagccttcttcatgtacaatgcttttggaaaaccttttgaaactctgcatggtcccctagggctgtaccttttgagcttcatttcaggctcctgtggctgtcttgtcatgatattgtttgcctctgaagtgaaaatccatcacctctcagaaaaaattgcaaattataaagaagggacttatgtctacaaaacgcaaagtgaaaaatataccacctcattctggctgactaaaggccacagctga

人全长野生型CLRN1蛋白异型体E(SEQ ID NO:45)

MPSQQKKIIFCMAGVFSFACALGVVTALGTPLWIKATVLCKTGALLVNASGQELDKFMGEMQYGLFHGEGVRQCGLGARPFRFSCYFLDPFMGLPTGVPHLLSLPCSTSCRREHTSERVQEPAGCFSAVRSKLHAGPAAATSFSRFAQSNPSEHPRQCHSLLCHPYCVNHGGDSLLHVQCFWKTF

人野生型CLRN1异型体E cDNA(SEQ ID NO:46)

atgccaagccaacagaagaaaatcattttttgcatggccggagtgttcagttttgcatgtgccctcggagttgtgacagccttggggacaccgttgtggatcaaagccactgtcctctgcaaaacgggagctctgctcgtcaatgcctcagggcaggagctggacaagtttatgggtgaaatgcagtacgggcttttccacggagagggtgtgaggcagtgtgggttgggagcaaggccctttcggttctcatgctattttcttgaccccttcatgggactcccaacaggggtaccccatttactcagcctgccctgctcaacctcttgcaggagggagcacacgagtgaacgagtgcaggaaccagctggctgctttagtgctgtgaggagtaaactccatgcaggccctgcagcagcaaccagtttttccagatttgctcaaagcaatcccagtgagcatccacgtcaatgtcattctcttctctgccatccttattgtgttaaccatggtggggacagccttcttcatgtacaatgcttttggaaaaccttttga

人野生型CLRN1基因组序列(SEQ ID NO:47)(NCBI登录号NG_009168.1)

1 aggagatact tgaaggcagt ttgaaagact tgttttacag attcttagtc caaagatttc

61 caattaggga gaagaagcag cagaaaagga gaaaagccaa gtatgagtga tgatgaggcc

121 ttcatctact gacatttaac ctggcgagaa ccgtcgatgg tgaagttgcc ttttcagctg

181 ggagctgtcc gttcagcttc cgtaataaat gcagtcaaag aggcagtccc ttcccattgc

241 tcacaaaggt cttgtttttg aacctcgccc tcacagaagc cgtttctcat catgccaagc

301 caacagaaga aaatcatttt ttgcatggcc ggagtgttca gttttgcatg tgccctcgga

361 gttgtgacag ccttggggac accgttgtgg atcaaagcca ctgtcctctg caaaacggga

421 gctctgctcg tcaatgcctc agggcaggag ctggacaagt ttatgggtga aatgcagtac

481 gggcttttcc acggagaggg tgtgaggcag tgtgggttgg gagcaaggcc ctttcggttc

541 tcatgtaagt agcaattgca tttgagttat ttaatgcttt aggcagactc ttcccagtgt

601 tgcgaggaat tatatttgag aattttgccg tgtttactgc aggacttttt aaatcggtgt

661 gaaccatatg aaaaacctat gactctgagc aatttcttct tcctagtttt tattatttta

721 tacttgcttt ttattataat atagagttaa ttcattgtta cataattaag gtttttggaa

781 atattggcaa ttaagatgct taagtattaa tatttatgta aaaaattatg gagtcttttt

841 aaaaaagtaa acttggggaa ataggaaagc tgtaaagaat gatctttatg ctttttgttc

第901章

961 attttgtttc ctgctcccca ctccctccca ttattcctgc taagaccttt cctgctgcta

1021 aatattcagt tttcattttt aactaatttg gaatcatttg gctatagaaatttaaaatga

1081 tctgctgtgc taactgggaa agaaatggat gcctatttag tatagaacattttaaactga

1141 ttgacctgca aatcatgtag agaatatgag agagattttc ttgttgtgatttttgtgaaa

1201 tggaagtgta atccacagta tttataacct gtttatctta agaagagaatttttaaaaat

1261 taccatgtga ataggcaact cattaaatga aaattaatag gaagtcatttgttatatctc

1321 ttacaacaca cattcagaag ttattattat ttcagaaggg ctggtttggaacaaccttat

1381 gaagacacag tcagtaaatt actgcataaa tcactcttca ggaaaggaggttaccaactg

1441 aagcatttaa aatgaattat tattttgccc aggttttttt tttctttctagtataggtag

1501 aaggctaaat taattgaatt tattattaac atatgcagtg cctaattaaatttcagtgct

1561 ggtctattta tatttctgca acattcctta tatcttctta gcagtcattggacaccaacc

1621 ttcagctcac ataggttact aagtgatatg aattttcata gggctccagaaaatttccaa

1681 gaattggttg ttagcttttt aattgatgaa gtggatacca gttcttttcactgaatggct

1741 tttattcatt aaggtaatgg ggctgttaga gttgcttagt tttcctggggaaggggaagg

1801 aagaaaacaa agcagaatgt catgtgatat gcaactgtat taaaaaaccgaaaaggaaaa

1861 aagttgagag agatgattta accgtgagtc accggcagcc aaagcgtgagtaaagcttct

1921 cacagatgaa tttagacaaa agcggagaag gtactggtga attttctggagcctttacat

1981 tttctacagt gaaatggaga taaactttac tcatgccata ggacatgtttcaaaacaata

2041 ataagatgtt ttctgaacac ttactacata ctaagcactt tatatgctttgtctcattta

2101 atccttacac agccacattc ttctggggtt tagcgaatga tttttgtggttgtgtcctat

2161 gcttgtcctg tctaaggatg aagttgttct aattgggtgc ccctccttttgctttctgtg

2221 aggacttgca gaactggtgg ggtttaaaca gtaccctcac ttatctcacagaatttcatt

2281 agctcccaga tacccctgac attctccccc tagcctagtg aagaaaatcttccatttact

2341 tgttcattct gcagtgacag ctccatcaat atacaataga ctatacatattaagtgtact

2401 gtatatacta tacatgttaa aaatctcatt cattttggtg aggcccagctaagaatactt

2461 acagtagagc tttttttttt ttcctaagca taaaagtatc tttttcaatgcagcatgaga

2521 cagagttggg aaaaccaaaa taaatagatc caatggactc cccaaagaggataatattca

2581 tttaaataaa cacccctctc agtgttaaaa ctttctaatc aacatgcctttgggacacat

2641 tgcaccctca aagtttacac tcccattgca acgcagcttt gtggttcacgttttttccat

2701 tcagaatgtc attaccctgt caatgatgtt tcatcaacgt ttgcttggatgagaatcctc

2761 tgatattctt cctgatagaa atgtataagc cctgttcata taaatgaataaaagatctaa

2821 ccttactttc tcagtagtgg cttccttgga gcaaaaagca gggacctccagagagctcag

2881 gtggatgact cttttctgtt tcttccagag ctcaacttac aattagtgcacaattcattt

2941 cccagaatgt cttctttctt attgtgcctt tagaaagtta ttaagcaaacatttgaattc

3001 acagaatctt accagtgtaa gaggaatgga aaaggtaact tatcaaggtaacaatcactt

3061 cgtggccagt tttttcggct cactgcaact acccctcctg ggttcaagcgattctcctgc

3121 ctcagcctcc caagtagctg ggactacagg cgtgcaccac catgcccagctaattttttt

3181 tttgtatttt tagtaaagac agggtttcac catgtgggcc aggctggtctcatggcaagt

3241 tttctttgtg ttgtcatgtt attatcaatt aataggaatt tatatttcagttctgttagg

3301 tggataaaca ctattttgca tacctaaatg tttcatttat atcagcactggccaataaaa

3361 atatactata agcaggccgg gtgcagtggc tcacgcctgt aatcccaacttttgggaggc

3421 caacactttg ggaggacaca gggtcaggag atcgagacca tcctggctaacctggtgaaa

3481 tcccgtctct actaaaaata caaaaaatta gccgggcgtg gcgggggcgcctgtagtccc

3541 agctacttgg gaggctgagg caggagaatg gcacgaaccc gggaggtggagcttgcagtg

3601 agccgagatc tcgccactgc actccagcct tggtgacaga gcaagactctgtctcaaaaa

3661 aaaaaaaaaa aaaaaaaaaa aaaaaatata tatatatata tatatattacaagccacaag

3721 ccacatatgt acttttaaat gtcctagtag ccatattaga aaacaaaagtaaaaaggaat

3781 agatgaaatt aattttaatg atttttttaa acccaagata tccaaaatattatcatttta

3841 acatataatt aaaaatttat tgagatgttt tacattgttt ttttttttcttgacgctgtc

3901 ttggaaatct agagtgtatt ttacatttac attacatcta attcagtctagccacatttc

3961 acatgctcat ttttttgtgt gtggttttat ggagcagaga gtttaataggcaagaaagaa

4021 aagagaaggc agaagaaaat ggctcccctg tacagagacg cgggggtggggcgctccaaa

4081 gccaaaagag gaggtcccta agtatggtag acaccagcca ggaatatatgcagtgtctgg

4141 aggaggggat gtctgatttg catagggtca catgctcatt tttatggctactgtattggt

4201 cagtacagat ttagatgggg atttgctctg aacaagttgg tgattgatggtgttcatatt

4261 ttaattgaat ttttcctggg ttctgctgta cacttgtatg tgtgttagtttcatgtgcaa

4321 tgcttgtgtc acttttaaaa cccagatata tggcataaca tgagaatgaaaaatggacca

4381 gaaaaatagt ttggcaatgt agtcatgttt gttcctatta aatgttccctattgaccact

4441 ctatctcttt taattataac aagaatctgc cctgccagca tgcccagttacgctgggaaa

4501 acttctgcct catttactct ggctgattct catccactta tgggtcagtggttcattttc

4561 tagaggtcac cagcattcat acctagcata caatttcatt cattataatgaaggaatgtt

4621 ttcccttcaa agagacacaa ctagtgggct taatttttct tgatatgtcacctgtaaaat

4681 tttaatgatg atgtttaaac tctaaatgta gccatcaaga caaaaactgcaaattttgag

4741 cctcagtgtg tgtgggtggg tttctgtttc ggtaatttga aacattgcagaatatcatca

4801 aaatatgata cccaagaatc atatggtatc aatcattcct agatatactgatctattcat

4861 tgccaagata gttcaatgag ctggcaaaaa catatggaat tattttcttaaaatgtgaaa

4921 aataaaattt aaccaatcat gtatcacagc ttgcaacttt agtcatactttgaaaagcat

4981 tttaatttgg acctcatgat tgaaaattta taaaaagctg aacagaaattagttcacttc

5041 atattttaga aaagcagagt ttctttacta aatgaggcat ttgacccaaattggagagaa

5101 aatgttgaaa ctacttctgt gagcaagcag gtggcttctc aaacacatgttgggatgaaa

5161 tggttgggcc tcagggtctc agtgcctgtc actgagagtt ggcactctctatctccatgg

5221 tctcctccaa gtgtgactct tgtctcttgc tgacctgacc tgccccaagtgactcactgg

5281 tcatgaccct gcacaccttg cgtctctcct atcaccctgc cgatggcagagctacaaagg

5341 tctttgatgt agctctgtct gatatcctgt gtttccccct atggtctgtgtggaagcagg

5401 tatgggggtg tgtaaagggg aagcctatga agttcatctg caaagactacctggttaggg

5461 gaggagagga agaagctata tgcaccattt caccagcaag catgggctcttctgcctttt

5521 agcttagggg tcctgttgtc tagtctcact cacctattaa aacagtccagcaaatagagg

5581 ttttgtttac ctcccattaa aaaaaaagca attaatggaa tagaagataataatgtatga

5641 gaagcactat tgtgaaagaa aaaccttcaa cttctctcag ccaaataattgcttcctcct

5701 ctgtccttcc cagaccttga tgtttgctct attatttcaa aacaactatattataaatat

5761 ttgagaatgt gtatttccct gcaaggagat cttaatcccc aagaaggcaggagctgtgta

5821 ttattcatcc cagtgctcct tcaaaccagg gcctcagaca gtgcatggcccaaagaggta

5881 cttaataaac gtttggtaaa ctgacactat tgaaattaag caacctggatttgaggtggg

5941 tctctgccac tcacaagaga ttacgctttg agaaaattcc atcacttcattgattttcag

6001 ttcttgcatc tgtatatggg agacgatact aggtgatttc tgacatctctcaccgtttaa

6061 atgctctgtg atctatacaa cgaggggctc gctgttctag acaagttccttccagcttta

6121 cagttgcata acccttctaa tcttagtcac atgatgactc cactgacagatttttggcca

6181 ccatcattag acatgctgag ttacgtgtgc ctttgctctg atcctcaaaactcatgattt

6241 ttaaagtttt ctgaaatatc taccatttat caggatccag atggatttcatgaccaaagt

6301 ggatgtttct tttctctccc attacaatct tttacttttt gtgtgggaaattgcatgtta

6361 aagaaaggga aattgaagaa tgggatgctt tggaattctg gcaagatggattagtgggtt

6421 ccagaaagta ggggcagcca caaataccga aataaatgag atcgtattattgagaaagca

6481 caaatggaag aaggtcaaaa gcaagaagaa gctgacatcc tgcttcctccaatttttgct

6541 ttctctgttt ttccaagaaa ctcctcttcc aagccttgct gaaaaactccactttcctaa

6601 atctaacttc ttaaactgat aatggcaaga agttaggaat gaccaatatgtttaacactc

6661 caagagtatt tgttttgttt tgttttgaga ctgggtctca ctctgtcgtccagcctggag

6721 tgcagtggtg tgatcacagc tcactgcagc cttgacctct cctgcccaaggaatcctccc

6781 acctcagcct cctgagtaga agggaccaca ggcatgtgcc actacacctggctaactttt

6841 aaaaaatttt tttgtagaga tggggttgcc caggcaggtc tcaaactgctgggctcaagc

6901 aatcctcctg cattggcctc ccaaagtgct ggaattatgg gcataagccactacgcctga

6961 cctctccaag ggcattcttt acccagaaga ggaacttggc agaacttatcctccaattgg

7021 tgaggaatat ggagaaaatg actttaagca aaggaacttc tggttctgcctacctaatcc

7081 agaaaaagaa gttttatttc tcccttcccc tagtaactat cttcccatattcacataaaa

7141 aagtacagaa tcaacattgt tcaagaatta taattttact tgtaagcacatgtgcacacg

7201 cacacccata taccttcctt ccctttaaat catcccacac cctaatagtagtaaaatcat

7261 tgacccgagc atacctggga gaggaagagg agtctgacag gggcaggttctaagtggcac

7321 tcctggaact taaccctggt gtatatgaac tttacctatt gaaggatgactcctcaactg

7381 ttctcacaat ttgctgctct gctttctttt ctaatttctg aaggtgactcatcttcccca

7441 aggactttca gacttctcag aagaaaaaaa tattgggtgg gtctctgccactggcaaaag

7501 attagacttt gagaatcata aaagtatatc agtatatact cattaatattgaattactat

7561 aattaatatt atgatattga tataatgata gaatgatatt gataaaagcaatattcaata

7621 atgaatatta tttcagctgc ccacttattg ggtgcctcat aggtgccaggcattttgtat

7681 gtattatcta caacccttac atgggacata ttatgatgct gtttctcttgaagaaatatg

7741 gaaactggaa acagagaggt caccacaatt ttccaaagtc acatagctaataggtagcag

7801 acttgggatt caaattcata tgcatatggt aaatcatgct cttcctctgctacattttgc

7861 ccccttagaa tatgaaaaag ggatacaaag agatgaagaa aatatgtaagattatccttc

7921 aatttcacta tcttttttaa agtttttttt attatacttt aaattctgaaatacatgtgc

7981 agaacatgca ggtttgttac ataggtatac acgtgccatg atggtttgttgcacccatca

8041 acctgtcatc tacattaggt atttttccta atgctatccc tcccctagtcccccacccac

8101 cgacaagccc cggtgtgtga tattcccctc cctgtgtcca tgtgttctcattgttcaact

8161 cccacttatg agtgagaaca tgcggtgttt ggttttctgt tcctgcgtcagtttgctgag

8221 aatgatggtt tccagcttca ttcatgttcc tgcaaaaggc atgaactcattttatggctg

8281 cataccattc tatggtatac atgtgccaca ttttcttaat ctagtctatcattgatgggc

8341 atttggctta gttccaagtc cttgctattg tgaacagtgc tgcaataaacatatgtgggc

8401 atatgtcttt atagtagaat gatttataat cctttgggta tagacccagtaatgggattg

8461 ctgggtcaaa tggcatttct ggttctaggt ccttcaggaa ttgccacactgtcttccaca

8521 atagctgaac tagtttacac tcccaccaac agtgtaaaag cgttcctatttctccacatc

8581 ctctccaaca tctgttgctt cctgactttt taatgattgc cattctaattggagtgagat

8641 ggtatctcag tgtggttttg attagcattt ctttaatgac aagtgatgatgagctttttt

8701 tcatgtttgt tggccgtata aatgtcttct tttgagaagt gtccgttcatatcctttgcc

8761 cactttttaa cggggttttt tcttgtaaat ttgtttaact tccttgtagattctggatat

8821 tagtcctttg tcagatgggt agattgcaaa aattttcttc cattctgcaggttgcccgtt

8881 cactctgata atagtttctt ttgctgcgca gaagtttttt tagtttaattagatcccatt

8941 tgtcaatttt ggcttttgtt gccattgctt ttggtgttta gtcatgaagtctttgcccac

9001 gcctatgtcc tgaatggtaa tgcctaggtt ttcttctagg atttttatggttttaggtct

9061 tatgtttaaa tctttaatcc atcttgagtt aatttttgta taaggtataaggaaggggtc

9121 cagtttagtt ttctgcatat ggctagccag ttttcccaac accatttattaaatagggaa

9181 tcctttcccc gttgcttgtt tttgtcaggt ttgtcaaaga gcagatggttgtagatgtgt

9241 ggcattattt ctgaggcctc tgttctgttt cattggtctc tgtatctgttttgatacaag

9301 taccatgctg ttttggttac tgtagacttg tagtataatt tgaagtcaggtagcgtaata

9361 cctccagttt tgttcttttt gcttaggatt gtcttgacta ttcaggctcttttttggttc

9421 catatgaaat ttaaagtagt tttttctaat tctgtgaaga aagtcaatggtagcttgatg

9481 ggaaaagcat tgaatctata agttactttg ggcagtatgg ccattttcatgatattaatt

9541 cttcctatcc gtgagcatgg aatgtttttc catttgtttg tgtcctttcttatttccttg

9601 agcagtagtt tgtagttctc cttgaagagg tccatcacat cccttgtaagttgtattcct

9661 aggtattttg ttctctttgt agcaattgtg aatggaagtt cactcataagtttgctctct

9721 gtttgtctgt tattggtgta taggaatgct tgtgattttt gcacattgattttgtatcct

9781 gagactttgc cgaagttgct tatcagctta aggagatttt gggctgagacgacagggttt

9841 tctaaatata caatcatctc atctgcaaac agagacaatt tgacttcctctcttcctatt

9901 tgaatacgct ttatttcttt ctcttgcctg tttgccctgg ccagaacttccaatactgtg

9961 ttgaatagga gtgttcacca cctattttaa gaatagtatt gaagcctcacaaaagctggt

10021 tctcatgtaa ccatctgaga atatttggcc ttatgacttg aattcattcattgccttttt

10081 atttcacatt ttagtgatcc tgatgtctaa atcttaatct ttgatccttgcaaggtaaaa

10141 tagccaagtc aagcctgttt aataatattg gttgaggaag tcacatgcttatgatcaatc

10201 tttgggttat gtaattatat taccttaatg ttggcagttt aggtgtaaggcagagatatc

10261 tgatcacatg tgtggttagc taatttaaga tcactgccaa ctaaaatcttcatggtatga

10321 tcttcaaagt tagctacttt gaccacagca atgatttcac cacagcaattaacaaaatgg

10381 cagactcttt cctgaggtgg catgaacagt tttaaaacaa agtcaaggaccaaaagaaaa

10441 gcaggcacat ggcatttgat tcatttcaaa aactagtatt gtattaagagccaaggggat

10501 agaattgtag catcaattaa aatcttgttt gaaaaaaaat aaaaacaaacgtccattttt

10561 atctctcaaa tatattaggg ttttcataaa gttataggtg tatttttaaaaaaacaaaac

10621 tcatatacat tagactgaaa aatttgcctg tcatctcatc atgcagctaaatgcaattgt

10681 ctatggcgag atacactctt attagaggta tgatagcact aactaatagcaaactttgta

10741 cctggtagtc taatttatgc agggttcata tttcgctccc tctcagcatgctgtaactgt

10801 ggcaaagcca ttctcaggag ttattacccc aacataatca tacccctgtggattaggagc

10861 agttaaatgg gtcctgttat cagagacaca tatgtgccac agccgctgtcatccctaagc

10921 caccgtgggt gattaagact cactgatggg actacctctg aataggcttgagtgaggtgg

10981 atacacttca gctgagagaa attcaggtaa ggggctgaga aaatcagattttgaatggtt

11041 ttatcatacc atcaggtctc cttttaagtg ctggggtcat ggatttcattcaacctgacc

11101 acatagcctt tggaagcttg gctcaatacc tgagtgtgag attatgggtgatattaaagg

11161 agatgaatgc attgagctga tgtcagagaa tgtcttttac tggattttcataatgactgg

11221 ctgcagatgg gctgagggga aagtcagatc aagagcattt ctgtaagaagaaagaaatct

11281 tccctcttat tctctttcaa gaaaatgaat agctgagcac caagaggccaaatacttttt

11341 taaaaaacac atccttttat gtagagaagg acaggttgag acgaaaaacaggacctctga

11401 aactgtcttt atagctttaa tctaggaaga aattgcggca ccattgctgacatcattatc

11461 agaggctgcc ttagttctga gagcttcaca gatggccttt tctgcattttacatctggcc

11521 agatgaaggc aaaaaggttg atgaaaccaa aactattaga tcagtggtccataactctgg

11581 ctgcacttta gaatcatctg gggagtcctt aaaactactg atcctgaggctccatcccag

11641 accaattgaa tcaggatctc tgggggtggg acctgagcat tggaatgctttaaaagttcc

11701 tcagggactc taatgtgcag ccaaggctga gaatgactga ggtggatggtggccaagaca

11761 ggtgaggcca agagttagaa gcccttactg ttagggaagg cagaagccacaaggaggagg

11821 ggagggggaa ggagcagtat ttagcatttc ttccacacag ttggggggttttctgatcaa

11881 aattaggctg ggatctttcg cttccatttt catgaaggtc ttatgctttgtccacagcca

11941 cctggcctca gggcaatgag caatctgatt gatgaatttt cagtaagaaactgagcacac

12001 ttggctctca gccccagtgg cttcccctgt ttccaaatct gcccaccagttacaggagcc

12061 tgctcaccaa ctggttgggt taaagaagtc ggctctgtcc ttggcagggaggccttcagc

12121 tgtctggccc tgtctgtgac tgcgtgggtg aagctgccta atttggggaacttgatggaa

12181 gatctaagct atgttctcta acagttttat cagaaataaa gttaacttttgacctccatc

12241 tgcctgtctc ctgtggaagg gctctgctcc ttccaaagag actctcaggggttctcctta

12301 gaggtgtgtt atcagtccaa agatcatttt agaccagcca ttacagaggatgtccaagaa

12361 attgcacaag ggaaatagaa gtaagaatga gagcaatata tcagatagtaaggaaagtat

12421 gtgactggtt tcaaataagt aattaaccat aaatccaaag ttcctgcattagttatagca

12481 atagtcatcc acctggtcag gaaaaaaaaa gtaaaagact gagctgcaagatagaaagtt

12541 tgcctgaatt ccacgtactt caaggactac tatggaggat tccttggtcccaatgcagag

12601 acatgtactc tgaccaccca tgggccaaat ccctcttacc caccctcagtgattcctcct

12661 gggacctcac tacattgagt tcttacattc cccactcttt tcgggggaaatataaccctt

12721 ctgctcttct catgatgtta aaaatattta gacaattact taaaatttacaacaatcttc

12781 cacataaatg atctcactta tgtttcttgt gagctctgtg atttatttctattatcatct

12841 atgctgatag ttaaggaaac tgagatatcg agaccaacat gcatagtaaatggcaaaacc

12901 agatgaattt taaactttcc taactccaaa agccacatcc tgcccaacccgccatgctgc

12961 cgctcagtta atgcctggct gtttgtctcc ccattggccc ctctacccattgtgctttga

13021 tggcacactg tattccaact gcctgagact cctggttaat gccattacgtacagacttag

13081 gttgaattta ctaggatttt taagatttgt aggataagag atatgactgttagactggaa

13141 tcagcaatag ataaaaggtt aacaaagttt cagaataaaa tataatagaaaaccccagca

13201 gatagaagta aaatgaatgg taagacaact gaaatgaaag ccatacatttagaaatatca

13261 aataaaacac agattaatgg cagacaataa aggaacatac ttagcagttagtaaaaacac

13321 tttttacctt attcttatta ccctccagta accttttttt tttttttttttgagacaaag

13381 tctcgctgtg tcgtccaggc tggagggtag tgatgtgatc tcggctcactgcaacttctg

13441 cctcttgggc tgaagagatt ctcctgcccc agcctcctga gtagctgggactataggggc

13501 ccatcactgc acctggctaa tttttgtatt tttagtagag acggggtttcaccatgttgg

13561 ccaggctggt cttgaactcc tggcctcagg tgatccaccc gcctcagcctcccaaagtgc

13621 tgagattaca agcgtgagcc accaagcccg gctgtaacct attgaaaataacattacttg

13681 acatgtgaga caaattattt gtaagttaaa gagtttatgt gccttcaatgctcccaccct

13741 tccctcccct aaaaagatta ttgagtgccc atgatgtgcc taagccttctggtagactct

13801 gagaatgtga agagagttag aggatacttg ttcaacaacc cagaatctagcagaagtgtt

13861 ttgaaatgac cagccacttg ggagagctat gctagcatat cattcaggatgggctgggtc

13921 atgttttaat aacaagtaag tttgaacttt ataggtttga aacaaaaaagatgtgtttct

13981 tgctcacagt tcatattttt tggagattgg ctggagcttc attccaggatactgccacca

14041 tctggaatgt tgacagttac cgtaacagag aaagagttgt ggaggctgtcacactggcaa

14101 ttaaattcgc tgacctggaa ctgacacatg ccacctccac ttatattttattggccaagg

14161 cttgttacac agccacatct aacttcagag aggtcaagat gagcaaatcctaccacgagc

14221 tatagatgga tgagtagcac tcattattat cacaattatt ttatttgttataaaaactcc

14281 aagaaggaga ggtactctat gtgaggaata ggcataggaa aatcagagggaagttcttaa

14341 agatgagcta gatttcacta gatggcattg aagaaacatt ccaagtaaatgaacagcata

14401 agcaaatgca tgaagaactt attgtggtcc tagtacagac gatgcgtgagagtgtggagg

14461 agggaaaagg taagactgga gaggaaggca ggaaccagaa caggacagactgtgttcact

14521 gtcaggcagt taagtctatc ttgtaggcaa catgaagcct tttaaggaaggcaagcagct

14581 atgtgacagg acagaagatg gattggaaga aaatcaaaag agaagtggggaccagtcata

14641 aggctcctcc aatatttggg gatccaaacc aaagcactgg cagagaaatagaaaggaagg

14701 gaaatatttc caaaatattc aaaacagaaa ccaagagaac ttgatgacagaagatgaacc

14761 caggtttcta ctgaatggac agttgttaca ttctctgaga taaggaatacagaaggaaaa

14821 agttgagagg gaatatgaaa ttatttttaa tcatgtttaa tttgatcacttgtggaacat

14881 caaccagaga tgtccatcag ttacaccaat ttgtaggttt tgagagaggcctgaggtaga

14941 ggcagagaag tgggaatcag cagattagcg gcagtagttg gaaccataactgaagatgag

15001 atttcccagg gaggggagtt gaacaggaag gtagacaaag gctgagtgcagtggctcata

15061 cctgtaatcc cagcactttg ggaggctgca gtgggtagat cacaaacaagatcaggagtt

15121 caagaccagc ctggccaaca tggtgaaacc ccgtctctac taaaaaaacacaaaaattag

15181 ccgggcgtgg tggcacacac ttgtaatccc agcctcagga ggctgaggcaggagaattgc

15241 ttgaacccgg gaggcagagg ttgcagtgag ccaagatcgt gccattgcactccagcctgg

15301 gcgacagagc gagactccgt ccccaccgac cccctaaaaa agaaagtagacaaagatgtg

15361 tcctagaaaa cactaatatg aatgggtaga gaggggagac ttgtcaaggagatcgagggg

15421 agagtcagtg aggtgaaacc ttagaggata gaccttcacc aaggaagtaacagtcaacag

15481 gcctaaatgc cacagagatg tcaaatgaga gacactggaa atggttctttgaatattaca

15541 gccagaacat cacaggagac catttccaaa gcagtcttga tgaagtggtggggaagggag

15601 gtccctgaag gagctaagga gggactggga gatcatgacc cagagataagtgttgcaggt

15661 ataaaaggga aagactgaga tcaggaaata gccacaggat ccctaaggccaggcttcggg

15721 tggggtggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tataaaatgggaagaccttg

15781 agtataattc tgtactaaga agatagagca gtagagagga aaaggctgaagacagatggg

15841 agggtaaata gtgaattaga aaggtctgtg caaagatgag aaaggatgagtctgaaagca

15901 cagggagaag ggccagcctt ggacaggaga aaacatttct ttcactaagaataaagggaa

15961 ggttgggtat acaccacaaa gaaggtgtag atgggtggca atggagttctgtcaagttga

16021 gggcattcca tgatagcctc acctttctct gtgaaatgag agagtttagtttacaagata

16081 tttctgagca cttcataagc caggttcata gactgaaaga agtggaggtggagtgtgata

16141 ggtccttaag aataggggaa gtttggaata tctgacaagg gacagagaggaaaaaactag

16201 aaaaggcttt gcagaatgtg ggcccacaga tcagaggcta aggggtccccatttgtgcag

16261 gagagtaagg gcagggaggc aaggctcaca gcccaaaata tagagcccctcaccaaatga

16321 ctgcaggagg gcagctttcc tatgagagca tccctatcac tgttttcactccgagtcatt

16381 aacttacgac ttactcagct ctgtttcgta atagcagact cgagtaatgagggtatgaca

16441 gcctctctct gcatgccaag gtatgcagcg tggatttcct ttttcgctttctctctcctg

16501 tggcttaggt gccttctgtt ctgctaccag gatagagaac ccagtgactagtttcttcta

16561 gctctctttt tctgactagg tatcttgtca gaaatttctg cttaccagacttcatggaga

16621 gggaatcaag ctttgaatca gggttgaaaa agtagagctt aatatatatattacaaaatg

16681 ccactcacgt tcttgaggtt accttgtatc tataccacaa ctagcattcttttagaaagc

16741 accattaccg aagtaatccc tttcctggga attcacccaa aaaggttattcccacttatc

16801 ccccatctcc aaaataaaaa agaaaaatgt gtgtgcttag agatgttcctggaagcatga

16861 gctgtaatac tgaaccaata gaagacgaac taacagattg cagggcatccgtttggcaaa

16921 aaacttatgc agttatctaa atgatagtta tgaagacaat atgtataacacattatattc

16981 tgagtgaaaa gaacagaagg tgatttcaaa actgcattgg gataatagtaatataggaaa

17041 tagtgagatg aacaaagatt tcaaaggaac aaaaataaag aaaaattttgctttttatat

17101 tggtaggcgt atgggtgaaa ttccaatttt aattttaatt tcatagttataaaattgttc

17161 ataaaaaaag gtcccccata gacagttggg ctttgggaca aactaacagaaacagagtag

17221 gaagaaaatt catcttcctt caatcccctt tctctgctta aaacaaaacaaaaaagagct

17281 ttgtcatgtt caggtgtgca acgaattctt tttccaaatc tggaactttacatctgctat

17341 taaacaggag tcagtttcca tgtaacatgt tgacaatccc ccaagtgtgttggaataatt

17401 ttttttaatg aggagatttg aaattccatt tcaattgcca acctgcctctttcaacttct

17461 aaaaacaaag taaaacaaaa caaaaacaca ctgggtccta tcaccccctcttgctactac

17521 tattttatct ccattgccct gaattctttc caaacttctt tccacccagctttgatttgt

17581 tttcagtcgg gtttattgag gcataattta cgtacagtaa aattcatccttcttagattt

17641 agaggtctat gcattttgac taatgcatat tggcttataa tgactaccacaacaaagata

17701 tagaacacac ccatcactcc cgggttctcc ctgtcccttt tttggtccatctcctctcct

17761 acccccaacc ccttggcaac cactgatctg ttttctgtcc ttatcattttgctttttcca

17821 ggatgttgta tataaggaat catgcagcat gcagcctctc gagtctgacttcttccagtt

17881 agcacagtta tttaagatct atccgagtta ttgtgagtag cagcatcttttttattgctg

17941 actagtattt catcacatgg atgggccaca acttgtttat ctgttcacctgtcaatggat

18001 actaagttgt ttccagtttt tggcaaatat gaataaagta aacatttgcatacagatttt

18061 tgtgtggaca catgttttca attctcttag gtaaatactg agcaatgggattgctgggtt

18121 atatgttaag tctatgttca gttttctaag ttctgaaaca attggatatctatatgcaaa

18181 aatacaaaat taaccttgac tcaaacttgt accatacaca aaaaataacctgaaagagat

18241 cacaggtgta aatgtaaacc tagaactaaa aacttcaagg agagaaacatagcagaaaat

18301 atttgtgacc ttgcattagg caaagacttc ttagatttga catttgaaacatgatacata

18361 aaaaatcttg ataaattgga gttcataaaa ataagaacta ctcttcaaaagacactgata

18421 agagaatgaa aatacaagcc acagacagag aaaatatttg tgaatttcttatctgataaa

18481 gggtttgtat ccagcatgca taaagacttt tcaaaactca ataataaacaatccaataag

18541 aaatgcacaa aagatacaaa cacatcatcg aaaatgacct atgaaaggcaaataagccca

18601 caaaaaaatt ctcaacatca ttagacactt gggaaatgca aattaaaacaacactgagat

18661 aaactacata tctattaaat ggctaccact ttaaaaacct gtcaagtgccagccagaatg

18721 tggaacaagt aggactctct tacattgcta gtgggaaggt gaatggtacagccactttgg

18781 aaaacactcc gcagcttctt atagttacac ataggacctg ggggtagaggatggattgac

18841 tgtaaagggg caaaacttcc tggtaggggt ggggaaagtt tttagaagggtgaaattgtt

18901 ctatatcttg attattgtgg tggttacaca actgtctgca tttgtcaaaactcacagaac

18961 tgtacactaa aaaggtatat ttttatgctc tgctaatttt actttaatcttaaaaatagg

19021 aaggaaaaaa taaaatcaat gccactgtgc gactttgggc aagttacttcacttctctgt

19081 gccttggtct tttgaaatct atacattaag gataaaataa taccttcctcatactgttag

19141 aattaaatgt gctaatttat gttttatata tataaagtac ttggccgggtgtggtgactc

19201 acacctgtaa tcccagcact gtgggaggcc gaggtgggca gatcacttgaggacaggagt

19261 tcaagactag cctggtcaac atggtgaaac cctgtctcta ctaaaaatacaaaaattagc

19321 tgggcttggt ggtgcgtgct tgtaatccca gctacttgag tggctgaggtgggaggatca

19381 cttgaactcc agaggtggag gctgcagtgg gctccaccca ctgcctgggtgacagagcta

19441 gactccatct cgaagaaaaa ataagtactt gaaacatagc aaatgttttataattattgg

19501 cttttttttc ttattgttat tacttgcatt attgctgttt gaagaagtttggtgataatg

19561 gagagaaaag ggcaattagg ggtctgggat ggtttaagta tgaggagaccgagacacatt

19621 gactcagagt gaagaaatca aagataagag aatgaaagaa agggagggtaattctgaacg

19681 cacagacaaa gttatgttac taacgtggca tcggctgtgt gttgtaataaataactccct

19741 ttcacttgtc aatagctaat caaatacttt ctggagacca gaagtgacttgctggatcaa

19801 tgacaactcc tccacagatc aaaatgttca aatccttttt ctgtgttgtaatcctaaatc

19861 taaaagaaca gagagaccaa gcaaatctac ctcccaacat cattaaagtgacaactctca

19921 gtatttattt gaatggtctg ctctcagctt caaccaagga aaagtcaaattagtgttggt

19981 cagaaaacag aagggtgtta cgagagttct ggctggtcat tacagacttggggatttttg

20041 attaaaagaa gaagaagaag aagaaacctg ataaagtgta aatatagcaagcagggatta

20101 gtgtcctgct gggtcatgtt ctcacaacag tgagaatttc agagatttcataagaattaa

20161 actgctccac atgacaattt attttacctt ctggcttttc caggaggcaaatcagtgcaa

20221 cttctttctg cctttgtttc aatttggtaa caaccctcaa ttttaggacaggctaaacct

20281 agccacccta tcagagatga tgaagtagcc atctttttaa caggtggggagatgaatgga

20341 atcagggttt gtttgtttgt ttgtttaata actgctagta aaaaccaagtcaatagctga

20401 ctgagtgtaa gggaggctcc agaaggcagg ttattgtagt atagatgtgactcgacttat

20461 gatgatgtta cttcccgata aacccgtcat aagttgaaat atcgttaaattgaaaatgct

20521 tttaatacac cgaatctacc gaacatcata gcttagctca gcctacgttaaatgtgctca

20581 ggacgcacat tgcctacagc tgagccaaat cacctggcaa cacaggacactgtagagtat

20641 cggttgctgg cccttgtgat gctgtgactg actgggagct gcgcttagtgcctctaccca

20701 gcattgagag tttcttatcg cttattacta gcctgggaaa agaccaaaattcaaaactca

20761 aagtgcggtt tctaccgaat gcttataact ttcagaccat catgatgttgaaaaatcgaa

20821 ccatcgtagg ttgggatcca tcctataaga cgagctacac tgccggaagtgtaagactgc

20881 tatgctgccg gaagatgggg catagtggac aactgcaagt cctgacaacaggaggtcagc

20941 atctgcgacc tttaacatcc acattgacac taccacagtc ttccaaacagagctgatgat

21001 atagtttgga tgtcgtccct gcccaaatct catgtcgaat cgtaatccccagtgttggag

21061 gtggggcctg gtgggaggtg attgggtcat gggggcagag ttcttatgaatggtttagca

21121 cggtcccccc ttggtactgt atagtgagtg agttctcatg cgatctggttgtttaaaagt

21181 gtgtggcacc tcccctctct ctctttctcc tactctggcc atgtgaagtgttggctcccg

21241 ctttgccttc caccatgatt gttaaattcc cagaggtctc cctagaagctaatgctgcca

21301 cgtacagcct ggagaactgt gagccaatta aacctcatct ctttttaaattacccagtct

21361 caggccgggc gcggtgactg acacctgtaa tctcagcact ttgggaggctcaggcaggaa

21421 gatgatttga ggtcaggagt tcgagaccag cctggccaac atggtgaaaccccatctcta

21481 ctgaaaatat aaaaattagc caggcatggt ggcgggtgcc tgtaatcccagctacttggg

21541 aggctgaggc aggagaatcg cttgaacctg ggagtcagag gttgcagagagccaaaatgg

21601 agccactgta ctccagcctg ggcaatggag tgagaccctg tctcaaaaaatatatatata

21661 ttacccagac tcaggtattt ctttacctga gactatgaga gaatggactaatatagctga

21721 agaattttat tttattttta aaaaactttt acgtttgggg gtacctgtaaaagtctgtta

21781 cataggtaaa ctcctgtcat gaggatttgt tgtacagatt ctttcctgctcctccccctc

21841 ctcccaccct ccatcctcaa gaagatccca gtgtctgttg tttccttctttgtgttcgta

21901 agttctcatc atgtagctcc cacgtataag tgagaacatg cagtatttggttttctgtcc

21961 ctgtgttagt ttgctaagga tgatagcctc caactccatc tatcttcctgcaaaagacat

22021 gatctcattc atttttattg ctgcatagta ttccatggtg tatatgtaccacattttctt

22081 tatccagtct gtcattgatg ggcatttagg ttgattctgt gtcttcagaattgtgaatag

22141 tgctgcaacg aacattcgtg tgcttgtgtc tttatagtag aatgatttctattcttctgg

22201 tagtaatggg attgctgggt caaatggtcg ttctgctttt agctctttgcagaatcacca

22261 tactgctttc cacagtggtt gaactaattt acactcccac taacagtgtataagtgttcc

22321 cttttctctg caaccttgcc agcctctgtt atcttttgac tttttaataaaaaccattct

22381 aattagtgtg atggtatttc attgttgttt tgatttgcat ttctctaatgatcagtgatg

22441 ttgagctttt tttcatgttc gttggctgca ggtacatctt cttttgaaaagtgtctgctc

22501 atgtcctttg cccacttttt aatggggttg tttttctctt gtaaatttaagttcctcata

22561 gatgctgggt attagacctt tgtcagatgt atagcttgca aatattttctcccattctgt

22621 aggttgtctg cttactcttt tgattgtttc ttttaccatg cagaagctcctaagtttaat

22681 tagatcccat ttgtcaattt ttgcttttgt tgcaattgct tttggtgtctttgtcatgaa

22741 atctttgcca ggtcctatgt ccagaatgat attgcctagg ttgtcttctagggtttttat

22801 agttttgggt tttacattta aatctttaat ccatcttgag ttgatttttgtgtttggtgt

22861 aaggaagggg tccagtttca atattctgca tatggctagc cagttatcccagcattattt

22921 attgagtaag gagtatctcc tccgttgctt gtttttccca ggtttgttgaagatcagatg

22981 gttgtaggtg tgtggcctta ttttggggct ctctatcctg ttcatttggtctatgtgcct

23041 gtttttgtac cagtaccatt ctgttttggt tactgtagcc ctatagcatatttcaaagtt

23101 gggtaacatg atgcctccag ctttattctt tttgcttaga attaccttggccatttgggc

23161 tctttttggt accatatgaa gtttaaaata gttttttttc tagttatgtgaagaatgtcg

23221 ttggtaattt gataggaata acatgtaatg atattgattc ttcctatccatgagcatggg

23281 atgtttttcc atttgtttgt gtcttctctg atttcttcaa gcagtgttttgtaactcata

23341 ttgtagagat tattcacctc cttgcttagc tgtattccta ggtattgtattctttctgta

23401 gtaattgtga atgggattgc ttttctgatt tggccctcag cttggtattgttggtgtata

23461 ggaatgctag tgattttttg tatcctgaga ctttgctgaa gttatttatcagctgaagga

23521 gcttttgggc tgagactagg gggtttttta gatatagaat catgttctctgcaaacagat

23581 ttagtttgac ttcctctctt cctacttgga tgccctttat ttctttctcttgcctgattt

23641 ccctggccag gacttccagt accatgttga ataggcgtgg tgagagagggcattcttgtc

23701 ttgtgccagt tttcagggag aatgcttcca ccttttgccc attcagtacgatgtttgtgg

23761 tggtttgtca tatatggcta ttattatttt gaggtgtgtt cctttaatacctagtttatt

23821 gacagttttt aacatgaagc agtgtttaat tttattaaaa gtcttttctgcctctgttga

23881 gatagtcatg tggcttttgt ctttagttct gtttatgtga tgaatcacatttgttgattt

23941 ccttatgttg gaccaacctt gcatcccagg gatgaagcct acttgattgtggtggtttag

24001 ctttttgata tactactgga ttcagtttgc aagtattttg ttgaggatttttgcattgat

24061 gttcatcacg gatatcggcc tgaagtttct ttttttgttg tgtctctgtcaggttttggt

24121 atcagaatga tgctggcctc ctagaatgag ttggggagga gttcctcctcctcaattttt

24181 ttggaatagg ttctgtagga atggtaccag ctcttcttta tacatctggtagagtttggc

24241 tgtgaagcca tcaggtcctg ggatttttta gttggtaggg tatttattactgattcccta

24301 aatagaccga taatgatttt agaagtggag tcggtttttt cctggtccagtcttgggaag

24361 gtgtatgtat ccaggaattt atttagctct tctaggtttt ctagtttgtgtgcatatggg

24421 tgttcatagt agtttctgat ggttgttttt atttccgtgg gatcagtggtaacattctct

24481 tcatcatttc tttttttttt tttttttttt ttttttgaga cggagtctcgctctgtcgcc

24541 caggctggag tgcagtggcg cgatctcggc tcactgcaag ctccgcctcccgggttcacg

24601 ccattctcct gcctcagcct cccgagtagc tgggactaca ggcgcccgctaccacgtccg

24661 gctaattttt tgtattttta gtagagacgg ggtttcaccg tgttagccaggatggtctcg

24721 atctcctgac ctcgtgatcc gcccgcctcg gcctcccaaa gtgctgggattacaggcgtg

24781 agccaccgcg cccggcccat ttctaattgt gtttatttga atcctctctcttctcttctt

24841 tattaggcta gctagtggcc tatctatctt attaattttt tcaaaaaaccagctcctgga

24901 tttcttgatc ttttgaatgg tttttcatgt atcaatcctt cagttcagctctgattttgg

24961 ttatttcttg tcttgtgcta gctttggggt tgacttgttc ttgcttctctaattctttca

25021 gttctgatgt tagtttgtta gtttgagatc taactttttg atgtggacatttagtgctat

25081 aaatttaact cttaacactg ccttagctgt gtcccagaga gtctggtatgttgtatcttt

25141 gttctcatta gtttgaaaaa acttcttgat ttctgtctta atttaattatttatccaaag

25201 tcattcagga acatgttgtt taatttccat gtaattgcat ggttttgagcgattttctta

25261 gtcttgactt ctatttttat tgtaccgtgg tctgagggtg tttgatatgactttggttct

25321 tttgcatttg ctgaggattg ttttatgtcc aattatgtgg ttgattttagagtatgtgcc

25381 atgtggtgat gagaagaatg tatattctgt tggttttggg tacagagttctgtagaggtc

25441 tattagatcc atttggtcca atgttgagtt cagatcctga atatctttgctaatttcctg

25501 cctccatgat ctaatactgt cagtaaagca ctgaagtctc ctactactattgtgtgggag

25561 tctatgtctc tttataggtc tctaagaact tgctttatga atctgggtgcttctgtgttg

25621 gatgcatata tatttaggat agttagatct tcttgttgaa ttgaaccctttaccattatg

25681 taacgccctt ctttgtcttt ttttttcttt gttggtttga agtcttctttgtctgaaatt

25741 aggattgcaa cccctgcttt tttctgtttt ctgtttgctt ggtagattttcctccatccc

25801 tttattttgg acctatgggt gtccttacat attttatctt tatctatccatccagccatc

25861 cagccatcca ttcatccgta tcatttttaa ccaataagga cttttaaaagcgcaaccaca

25921 acaccattaa cataaccaat aaaatctata acaatgataa aatatcatctaatactcagt

25981 ccatgtccaa ttttccctcg ctatctcaaa atcgtcttct tagaaatggtctgttcaaat

26041 gagatcacat ggacagagga aggcgaacct cacactgtgg ggactgttgtggggtggggg

26101 gaggggggag ggatagcatt gggagatata cctaatgcta gatgacaagttagtgggtgc

26161 agcgcaccag catggcacat gtatatgtat gtaactaacc tgcacaatgtgcacatgtac

26221 cctaaaactt aaagtataat aataaaaaat aaaaataaaa aaataaaaagtgaaaaaaga

26281 aaaaaaaaaa aaaaagaaat ggtctgttca aatcacaaac cagattcagaaacaatagcc

26341 atacattaca ttttattaat atgtctctta aatttctttt aatctattacagtctttgga

26401 atttttatgt cttcgtttat ccttccaatt attaaaaaaa aagtatttttgtattcattg

26461 aatagacaat gcttgcagaa aagtaaaaaa aaaaaaattt agtacaaaaaggtacatagt

26521 gagctgttcc ttagtctccc ttcccagaag caatgttacc acttttgtacaaatagtctc

26581 tgcctagaca cacatgccag tccctaaggt ggctgtaaca aggtggttaagagtgagaac

26641 atgaattcaa attcctatta tgccactcac taagtataaa tcttggtcatggtacatgcc

26701 tctgtgcctc agtttttaat aatggtacct acctcatagg gctgttgagagaattaaatc

26761 agataagtgc ttaaataact attaatattt attattattc acattcccttttggcttttt

26821 tcccaaatag cagagtggtg cacatatgtc ttcatttatt tggcttgttttttcacctca

26881 catcacattt tgatgaataa ttccatacat gttgttatag atttgcttcattctttgtaa

26941 tcattgacta atattccatt gtatgaatat gctactgcta aacatgtacgttatttccaa

27001 cctcttatta tcaagaaatg ctgcaatgaa tatccttgta atactttagtggattcatgt

27061 gcaaaaatat tcataggata aaatcctgaa agttaaattg ctgagctaaagggtatgtgc

27121 attttaatgc tttatagatt gcccagctgc ctcaaaggag gttataacaatttacactcc

27181 caagaaaaat gcacaagggt ccccatttcc ccatacccta gctaacacaggatattgcta

27241 aatgctttca tctttgtaaa catgatgtat tgaaaatggt atctcaaagttttaatgtgc

27301 atttttctga ttgtgagaag ataaaggaaa tgtagtacaa ctaaacatcagcagtcaaat

27361 gacctggcca tgactcctga gtgaggacac tggtaaacac catcaggatccaaacacctc

27421 tgtatttacg aagaggatgc tccctattgg atagcactaa gcttatttcatgtatgtaca

27481 tatgtagtta gttaattaca tccagcggtg gcaaagggct tgttctgacccaatgaaact

27541 ttctctcctg gcccccttcc agcatgtggt caggagtaga gtgttgtggccatgaggcat

27601 gcatttgtac agatgactac ttactcctcc ttgaaacatt tttttccatttgcttccctg

27661 ctgtctcact catgggtctg ctcctaattc acaaatcact cttttcccagtcttcttggt

27721 tgggttttct cctcttctgt gcttgtagac atgggggagc cccagggcttctctcttgaa

27781 ctacagcttc tccctgggtt catctccttg ggatgtctgt tccaatgggtttaaatacta

27841 gggctaggac tagggagagg tcattgaggc acttagcaca taaagtttaaggaaacattc

27901 tttatcaggc ccatgcaagt gcaggactgg ccctggaggg tgactaccaccttacctttt

27961 ccaccctagg caccttgttt gccttaccct agccccagtc ctctttaacaccccagtctt

28021 ctccctggac ctccagaaac ataaatccta tttgacattt ctacttggaggttttaaggt

28081 aactcaaacg taaaatatct aagacagaac tcttgcatca cttcccatcctggggcccaa

28141 gcctgtctct tctactagtc tatctcagtt aacagcatca ccatttattcagttgctcag

28201 gacaaaaaat ttgaagtaat ccttgactct tctttttttt tttttgagacggattctcac

28261 tctgttgccc aggctggagt gcagtggtgg gaccttggct cactgcaacctctgcctcct

28321 gggttcaagc aattctcctg cctcagtctt ctgacctcgt gatccactcgcctcggcctc

28381 ccaaagtgct gggattacag gcgtgagcca ccgcacccgg cctggattcttttttttttt

28441 tttaaacaag tcctatcttc catctccaaa atgtatccca aatctgacaacctctcccac

28501 cgtaggccag cccccatctc tcccctctga aaatagcctc ccttagatctctggacattt

28561 gttcttcccc acccccttgt gatcactatt cagcattcag aatgatcttttaatattatg

28621 aaggagactg tgttcctctc ctacttaaaa ttctctagtg gcttcctaataaatttagaa

28681 taaaaagcca actcctcgcc atggtcacca ggccaggatc cagtgggtacaacaatctgt

28741 tcccagcaca ataatcccac ttctgcctcc ccaccattca ccaggctccactgcactggc

28801 tcattcctgc ctcagttgtg cttcttttcc ctggaaagtt ctttctgtagatctttaaag

28861 ggtgatttcc ttctcaacat tcaggtgtca gctcgtttca ctttcctgaccatgcccatc

28921 cactcagaga tcactcaaaa tcccattacc ctattttatt tctccatcatatgtatcact

28981 atctgaaact atcttgttgt tgatgcaggc tattttcttg accccttcatgggactccca

29041 acaggggtac cccatttact cagcctgccc tgctcaacct cttgcaggagggagcacacg

29101 agtgaacgag tgcaggaacc agctggctgc tttagtgctg tgaggagtaaactccatgca

29161 ggccctgcag cagcaaccag gtaggggtgc ctgcaacccc agggccccagagggtgtgtt

29221 acaatgctct cgtagctctg ccatctgtgg acagcagtgt gttgtcagctcagtgggccc

29281 tttgcttcat catgtagggt ggctgccctc tgcctgtgag ggcaaagggccagggtgaca

29341 gtctttttgg gtacccacaa tttgtgcatc ctgaattctt gtttggtgcccaagaagaat

29401 ggggtcacac agatgaactg aaggatggtg aatgcagaga attagcaatgaaagtggctc

29461 tcagcagaga gagaagctga aaagggaatg ggaagggcag gtcactctcccctgaagtca

29521 agtcacatct ctccaatgtc cagccaccat ctctgaagtc aagtttcctctctctgatgt

29581 ccagccactt ctcctctcta ctggctgagt ctggggtatt tataggcagaggataggtgg

29641 tggggcaggc catacataat tttggaaaag gcaacattct attggtaaaaagacattatt

29701 cataaagaac caattgggaa agagcgggca cacagggatg gaagttctcactttgggctg

29761 caggtttcag gcttttcagc tcaaaagtga ggtttttcca gggacctgccccgtctgcct

29821 aaaatttcta cacttctgtc attgataccg ctggataaca gctctcctataaagttcagg

29881 ggcttaaaac aaaaatttac taattcaccc ggacagttct tgatagggtctctcctaact

29941 gttgcagtta catagcaact gggttggagt catcttttct gggcttgacatccaggacag

30001 cttcttccct tgtgtgtctg gtgcctcagt gctcctccag gcagcctttctctccagaag

30061 agtagcctgg acttcttggc aactcaagct tccaaaagaa aaaaaagcagagactgctgg

30121 ttctcttatc aaacaggcct ggaactggca caatgtactt ctgctgccatattcaggagg

30181 tcaaagcaat cgaaggccaa tccaagttca aaggcattgg agaaaaatgagaagtgtcac

30241 ttaaatgaga agtgacacat gcgtaaaagg gggaaaagca ttgattgtggccatttttgg

30301 agataagcta tcacgtttat ttgtttgttt gctttctaat ggtctgtcttctcccattag

30361 gttataagct ctgtgagaca acaggaatct tgtccatctt gttttatggctctacttcca

30421 acacctagaa taatgcctgg cacatagtag gtgctcagtg aataacttaagcacttgata

30481 catgtttggg gaactaaaat gaacagaatt aaacttcccc agattggtcctgccagattt

30541 gctgatgcca agcatgctga tgcctcacca gatgaaagaa gccctaaaatgtagggtttc

30601 gctttctctg caaacaagaa aaacttgccc tgaacacaaa atctagaaatagatttggcg

30661 tgttttctac attgaaatat ttcccgtagt accagaaatt attttcccacagctttgtgc

30721 tacattaaaa tattgaagtt gactgaaaat atctccattc tttaatcttggtgtagacta

30781 gaaacaattt ttttgtaaca aagtaaatat gaaaacttcc taatatttgaactccccaga

30841 tatccccaga tatctccaaa cttaaaatat cattgcaagt taagataaatttttttaaat

30901 gactaccgag aaaggtcatt aaaggcttgg ttattaaaat gtacagatttgggttataaa

30961 gccagaactt atttgtttaa atcattacat atgaccaagc acagaaaataaattacctca

31021 aatctcctct ttgctaattt ttactggtaa actctataaa atgatcctatctttaaacct

31081 ttttgtaaac cccttataag ttagtaagtg agaatgtatt catcagaaggattttagtga

31141 tgtttgaaat taaaaaagag agatttgatt tttaaaatta tacttgcagactactgctaa

31201 tgaaacttct tctaacccta gttttgtctt atcttcagtt tttccagatttgctcaaagc

31261 aatcccagtg agcatccacg tcaatgtcat tctcttctct gccatccttattgtgttaac

31321 catggtgggg acagccttct tcatgtacaa tgcttttgga aaaccttttgaaactctgca

31381 tggtccccta gggctgtacc ttttgagctt catttcaggt aagtacaaaattctacctct

31441 gaagacaaat gtgcttttca atatgtcaaa aagaccgtct acctaaatataaagttataa

31501 tcttaacata tatacatgga tgcacactgt agtattatac ataataacaaaaagtgtgga

31561 aataccacac ttgctcaaca gtagggaatt caataaatac tttatggacatctatatgaa

31621 taactgtgat gctgacatta aattatattt ttgaagatgt aatcaagaggataaacgctt

31681 gtctcaaaaa gttacatggg aaaagcagta tgtaaactta tataaacattgtgaacctaa

31741 tttgattata tatataaaat atagggaata tacatataaa atacatatatgtatatatgg

31801 gggctatata tatatatata tgaaagagat agatagatag atagatagatagatagatag

31861 acagacagac agacaataca gactccaatc tgttggtcgt ggttgtctctgacccatgac

31921 actatggggg acttttattt ttgctcatac ttttcaatat ttcttagtgttcaataatgt

31981 gctattattt atacataata ataaaaataa ataaatggca tcaaaaaagagtaaagggcc

32041 agtgttccgc ccacatatga gcagccatat tcaagcctgt agacactttgtgtagcctaa

32101 tgctaggtgt atctgggcaa ggataaactc taaagccaga aattagttcatcaataaaca

32161 tgtgctactc aatagctagg gctgatggaa aagaatataa aacccagtctgtgccaaatg

32221 gtgcttacta tctgcaagtg ggagaaggag aaagacgaga aaatgaaaaatgtgtgtata

32281 atttatatgt agctgttctg taggagatct ctgacttcac cccattctaactttgcaaaa

32341 agatccaaca ctttgtcaga ttcctgggag gcaagtaatt ttattgatggtttcatggag

32401 ggatacagaa cgataacaac tcacacaaag caaacaatgt aatgaaaatctctattcgac

32461 tgtttctttt tctcctgaag ttgccctttg gctgccagct accaggcaccaggctcaagg

32521 tactttcttg ctcttgacac tactcccttc tctcatacaa ttcaaccccaaccacaaacg

32581 tgtatagatc tctctctcta taaaacaaag gcctgtagtt aacaggaggtcacttgcagt

32641 gtagcctctg ttcattgtta cttgtgcaca ctgcttaggg tctcaccccatccacattct

32701 gctaatcaca ttattcaccc atccaatgta gatctctcca gtggagattctgctaatatt

32761 ttctttagat ttgtcacaag tatataatac agttttaaat tgtacagatgattatcctat

32821 aacagaagag tctaagcctt ttacatcttt gtatctctaa cgaaagcattcagcatgaag

32881 ctctgtacac agcagacaat tcaatatgaa tttgctgact tgaaacagcaagcctagaaa

32941 ggagatgtta acttggtcac ttagacagaa caggtttcag caatcagaattcagatgaca

33001 tggaactggt agaacaggcg ctttgaagca ataggacatg agccagtgaggagagggatg

33061 gaatatcata aacaaaggcc aagggctttg caatcagagc tgaagagccaagagcacagg

33121 ctcagggtgt gggcagactg aatgagaaag tgattcaatc acatgtgaaagtccagatga

33181 gaagagagag ttgggattac ttctgctcac caaacatcca aaaccaaacaggtggatccg

33241 ggtggtgtgc tgttttactg atgaccatta cacagaattt taacagaaggaatgtaaagc

33301 agtggttctc aaactggagt tcccagatga gcagcgtctg catcatctggaaacctgata

33361 aagcagcaaa ttctcaggcc ctaccccaga cccactgaat cagaaacttgggggtctggg

33421 ggaagatggc catctgtatt ttaacaatct cccttcagga gattctgaggctggctcaag

33481 tttgaactac aggtagttgg ttcaacaggt gttggtggac tgacaaacaaaaagagactc

33541 cgaggtaact ccaagatggt aatgtcagaa agcagctacc acccctagggcttgggggaa

33601 ccaacaaaag agtttggcat tgccagaacc tagaatcttg aggagaggccccagagcatt

33661 gtgtctcaga ccttgaggac ttggcactgg gacaccatga ggggtttctgggtgtgggaa

33721 agggctggaa actccccagt tgctgccacc agggagaact acaagtgaagtggaaggtgt

33781 gggcctttct cccttttctt ttctcgtctt ctctctcccc ctggtgctcatgtttgacag

33841 aaaacagctg aaaaggcaga actagtttgg ggagtcttga cctggcatcataaagcagag

33901 aaaagcaaag ctggagtgaa ggtgagacac aacagctcat tagcagcaacagccgtctag

33961 cgctccagct tctgaatgaa attctgaaga acagcgcact tggaagacaaattatttgac

34021 agttctgaca gacgaccaaa ctaacagcat ttgaaaagca agatgactcagagaatacag

34081 aatttaatcc aaatcccaga tcctatctct gcctttggcc aggcctaatgcaaggagaac

34141 ctgagcacac aaatatatgc aggaatgatc aggacctgtg cctgcattctattctgtctc

34201 acccaccttc aaatttgttg taaaaacatg ggctcaataa aggtttgtgaatcagggaag

34261 gaagagaagg ggagaaagga agggaaggag ccagctccag atctgtgtcttgcagaggat

34321 aaaggccagt gtttttagat cacccagtgt ttttctaagc ccccaatacttattttgaaa

34381 tatcaaaatg ttcaataact aaaaaaaaaa ccgttacaac aataaaacatgtttgagggt

34441 cagatggact ggcagtttgt gacctctggg gataaacagg tcactttggaatcacagact

34501 tcctcattcc ccttaaatct catatggtac ccagaagccc ttggaactttggaaggtgtt

34561 tattcacagt tgtaatgtcc atgcagaccc tggctctaag acccaattgtgtaagggtag

34621 gtttgtagcc cttatcccaa acattctaag tgtgagccaa tgcgtcacacactcagaggc

34681 cagagactgt attggggtcc tttatttcac gtacgagtca cattccattaagagacccca

34741 gaagtcagct ctcttccact gactggttct cttcccttgt ttctcttgccaatgtgtgct

34801 gcccaggtgg cagtgctcac tgtcagcaga gaagaaaaat gctttcctccttggacctct

34861 tttctctttt tctcctccct actcacattc aggttcccta agcttccccgctccttgtgc

34921 tgaagtcatt ctatggtcat ttcttcaact gtctacttcc ctgctggatgggcacccaag

34981 acttggcatc ctggggcatg tagaaagggg aaagggaagg gaagggaaaagaagtcctcc

35041 caattgtcta tctggacctt tccacactgc ccagagtact gctatgggcatctccttatg

35101 tctcccgatg tggtgcatgc cagaccctgc aggtagaaaa ggaaagaaagcaacccattg

35161 gaccaggcca gcaaaggctt cagtcacaca gctggctcat acttatggcttcatattctg

35221 ttgcctcttg aaccagacat ttcttccact ctcataacct ccagtttagctcgtattcct

35281 cagcattctc catgtaatat tgttgcatga aacccatgca agtcagccaatttgctcttt

35341 ctcatcttgt catttataaa ttgatgctga gaagtctttt tcccaaggtttttagtaata

35401 ccttcatcat cccccatagt tcattttggg cagtgattcg cttctttgactgtacattag

35461 aatcatctga agaactttct aaaactactg atctcaggtc tcacacaacactaattaaat

35521 tatagtctct ggtggggtag ggcttgggca ctgctatttt accttaagctctctggagtc

35581 attctaattt gtagccagtg ctaagggttg caatataagt gaatatatttcacgtatttg

35641 tcaaacattg actgagtgcc cattatgtgc cagccattat aataggcactggtgatccca

35701 cagtgaatca ggcacacaat gctgtcttca cggagcttgt tgtctagtgggagagtcaaa

35761 caaaagtgta tatcaataat taagtgatta cagattgcaa taattacaataagggtgata

35821 aacaggttgc tataatatac aatagtattg cctttcacca gacatttcttaaagaggtaa

35881 atcatctatc agacaccttt taaaaatctc atctaatttc aaaagtgtacataaataatt

35941 aagtgattac agtttgcaat aattacaatg agggtgataa acaagttgctatgaaagaga

36001 aagatagcag agatctggct ttgagatggt ggtcagggaa gactgctccaatagctgagt

36061 tctaaagcta agaaggaact gagaaccttc acagaacgtcccaagtagaagagaaagcac

36121 actgaagact ctagggaaag aggtctgctt gttgtaggaaccgaaagaaggccaatgtgg

36181 ctaggtgctg ggtagtgagg ggaaatggca caaggaaaaaatgaggttagagagatcagt

36241 tgataccagt taatgttgga ccctaaacat taaccatggt aagtcttttagaattgattc

36301 taattgcaat gaaaaccttt tgaaagattt taaaaagata tctgatagctgatttacctc

36361 tctaagaaat gtctggtgaa agacaatacc atcacattgg agatggaaaaagatgaatgg

36421 attctaaaaa cattctgaaa gtacattcaa aatgtttttc aggtagcttatgcaactaat

36481 aaatagtggt ggcattctgg gtaagacaag ggaggagcaggcttgcagtttagggcaaga

36541 aaggggtggg gagaagagct cagcactaaa atcatgtgtt ccatttggggcacatcgagt

36601 ctgagttgct atgagaccac caagtggaga tgccaagtaa atagtcagttacatgaatct

36661 ggagttcagt gaagaggtct agaagaaaga tgtatatttg ggcattattcggatatagat

36721 attatgtaaa gcaataaaat tggatgagat cacctaggga gagaatgcacatagataaaa

36781 actgacctag gaccacttca tgtctaaaac accaaaagca atgtcaacaaaagccaaaat

36841 tgacaaatgg gatctaatta aactaaagag cttctgcaca gcaaaagaatcagagtgaac

36901 aggcaaccca caaaatggaa gaaaattttc acaacctact catctgacaaagggctaata

36961 tccagaatct acagtgaact caaacaaatt tacaagaaaa aaacaaacaaccccatcaaa

37021 aagtgggtga aggacatgaa cagacacttc tcaaaagaag acatttatgcagccaaaaaa

37081 cacatgaaaa aatgctcacc atcactggcc atcagagaaa tgcaaatcaaaaccacaatg

37141 agataccatc tcacaccagt tcaaatggca atcattaaaa agtcaggaaacaacaggtgc

37201 tggagaggat ctggagaaat aggaacactt ttacactgtt ggtgggactataaactagtt

37261 caaccattgg ggaagtcatt gtggcgattc ctcagggatc tagaactagaaataccattt

37321 gacccagcca tcccattact gggtatatac ccaaaggact ataaatcatgctgctataaa

37381 gacacatgca catgtatgtt tattgcggca ctattcacaa tagcaaagacttggaaccaa

37441 cctaaatgtc caacaatgat agactggatt aagaaaatgt ggcacatatacaccatggaa

37501 tactatgcag ccataaaaaa tgatgagttc atgtcctttg tagggacatggatgaagctg

37561 gaaaccatca tcctcagcaa actatcgcaa ggacaaaaaa ccaaacaccgcatgttctca

37621 cccataggtg ggaattgaac gatgagaaca catggacacg ggaaggggaacatcacacac

37681 tggggactgt tgtggggtgg gaagaggggg gagggatagc attaggagatatacctaatg

37741 ctaaatgacg agttattggg tgcagcacac cagcatggca catgtatacatatgtaccta

37801 acctgcacat tgagcacacg taccctaaaa cttaaagtat aataataataaaataaaata

37861 aaataaaaaa acaaaaattg atgtaggacc aattcctgaa gaacactgacagttaatttt

37921 ttggtttagg aggaggagaa gccagcaaac gacactgagt agcaatatccaaagaaaaag

37981 aggaaaaagg aaaactggga gattatgagt gtcccagagg gaatgtttcaagattaccat

38041 cagcagtgag ctttgtgtaa aggtggcctc ctgtaataga ggtgcgggcaggagaaggca

38101 gaatagggaa aagggggtga aaaagcttcc ctcaagattt ataatacagtggaagagaga

38161 gacagagaga gagaaagaga aagagagaga gagaacttaa ggaggtagaggaagagagag

38221 aaccaaaaaa gagggagctg agtatagaag caattagatt catagtttttagttgcggca

38281 gtgatatttg agtgggggcc ttttatatat tccattctag gtgtttcccagttgatggga

38341 gagggtctta cctagatctg catgtaaaag ggagtaggcc agctggcagacttgacatgg

38401 atcagtggta gaacatccta gcagttctgt gaatactctc tgagaatgacatgaaaggta

38461 ttggttcagg ccttttggag gtgataaaaa ccaccaaaat gtggacttattgcaaattgt

38521 atttgttacc atttgcaatg attataatta ttctcttata tataggctttcttacatata

38581 gcttctctta cacatagcgt catgagttat gccttctctt acatatagtgtctgctatga

38641 gttatgccaa gcagggcaaa caaaattgct gcctttcttt aaaaagaggacgctcctagt

38701 atgggcctaa ttaattatga taattacagc tatggcatgg aacataagcacattcatata

38761 cacaaagaca ataaaataaa gaacagttca aaaacagaac agttacattatatatcagtt

38821 tcagtatgaa taataccctg gactctgaaa tatgtctggg gcacattattctgtaattgg

38881 tggtgaaaaa aaatctgcat cttatctcta cgccaatcct tatgaaggagctgtttttca

38941 ggagttcgag aaagagacac agggatgtcc agtcatcaaa gccgcagagcctgaggaaga

39001 ataaaggatt tgtggcagga aaacccagta atgaatgtat tctgctagtttctcagcata

39061 gaacttagaa aagaggccac agaaggaaaa gagaagtaat gttagacagctgatgttggc

39121 aatgggcaaa gaatttcatt ctcatatgca gggcagtggc taaaggggcagtgttgtgag

39181 gaatcacatt ccaggtcatt catgtccagg gtgtggtagg aggactgtgtttcatttatt

39241 ttgtacatgg cccagctatg accttgtgca aggaaatgct taatcattttctatcacagt

39301 tgcaaagaga ttcttatcct actcagaatg tacgtcttct cttctgtttcatttacagtc

39361 acaacccaag tccttgcttt gacctccaaa gcaccacttg atgtatccacttcagaaaca

39421 cacacagaca gctcacctct ttctatccct taccttcctc ccctcttcactcaaaccacc

39481 tacttccttt gcattcactc ttccttcagc ctgaaataat cttcctccaaatatctacct

39541 tctcactccc tcacttctct caagatacac ttaaatgtta tattccctatgaggcctccc

39601 ctggccatcc ctccccagcc ttcctatccc ccctctctgc tttattttattctccttaat

39661 atatatcaca ctctgataaa ccattgaatg tacttatcaa gttattgcctctctctccct

39721 ttccattgtc tccatcactg agagctctgt gaagaaaagg atttgtacctgtttcattta

39781 gtgctgtacc cccagttccc acaacagcgc aacaggcact caataaatagttgttgaata

39841 agtgaataaa acagaagtag ctgcatattt tctggtaaca aatgatattcttctgaaaat

39901 gtcatatttt cagacatatt tccgaaaata aattcaaatt agataaacattgtattttta

39961 gaccatttct tctttgcatt aatcatcctt ctcaataata taacatttgtaaaacttagg

40021 ttagatatgg gctcttcaac tttccattac agaagataaa gtgaaaaggctagacccaat

40081 ggtgttattc cttcatctac atctatcctt tggaaacaca tgaccaaattgcttgccatc

40141 acaatctcaa aatctaccct ttggtattaa ctcacttcac ttgtccctctgtcccttttt

40201 agatggtagc catcggtctc tggagcagtg tagagtcaga acaacttctatttggggaag

40261 aaatcattgc tggtgacctt actttcaatt actaactttc tagtgacatttacataattt

40321 tagagaaaat taacacctac acttgtaaag ttgtggcttt cccacacctatttatcatct

40381 ctcaatattc cttgaaaagg aaattatcaa tttatcattc tatattggcaatgaaatgcc

40441 cctaatatct gtcacctata agacaattga agatgatgtg ttgaaagctttctgaaaatg

40501 ctgatcatta ctttaaatgg aattgaaatt ccagtttatt atttccaaaaatatgatctt

40561 actgatcata ggataacatt tcataacatt tcagagattt cttccccttcgaggagccaa

40621 acccatagga cctctggact cccacagatc ctggcaggga gttcccactcataaaagcac

40681 aggtgccctc agagtcattc agggatgaag aagcaaccct cattggccatgtcctacgtt

40741 ccccatatag taaggactgg aggagaccag tgctcaattc tgcagtctcagacagctgtc

40801 agaggagagt catgaatgtg cagtgtctag cacattacaa acgtttgttaattgactgat

40861 cattcatggt gtgacagccc tataactcag ctatcctatt cagtcagaaattaactcagt

40921 aatcaaagtc attaaaagga agaaaaaaaa aacctacagt accagacagatggtggggaa

40981 atcagacaga tgaaaggaaa aatggctgta ggtcattgag taagacactgggcagcaaaa

41041 cctgggcctt gtgcctggtt atactccaca ttatagctcc agcaaggtttggcaggattt

41101 ccacagtcct ggcttattct aacctttctt gggagcagga gcagtgttggtcagatagac

41161 agacacataa ggaatctgtc caactggcac cgtgtgaatt tgggctcttggtgtacatgg

41221 ataactggga aaaagaggag agagacatgt aggactgatc ctaccgtttgtgaagtcttg

41281 ggcaagagta tgaatgaaaa cccacttctc ttcccctgcc tggctccactgcacacagta

41341 aagagcctca agcataggtg tgtggacatt gcaccatgta tccaagctctgaccatgcct

41401 cttgaaacag ctattcctca gccaccctct gaccatggga ggaatgacccaggagaaatg

41461 accacatagg tcttgaaaat gggctcaggg ctatttacga agtcaattccggggtcccag

41521 gagtatggac taaaatgtga gtcaggcatg ccagatgggt atgttctattgacttcaagg

41581 attcctcatg ctgtgggaag gaacctctcc agaagagaga cagagcagaaccctctaaat

41641 gtggggcaca aagcaggagc ccctcttgct ggattcaaag ggtcatactggaagagtgta

41701 ggttgagtct tattctcaca tcactcatat cacttacaca cttcttttatagccttagca

41761 gccatgccac aaagagaaac tcttcatgca tatcttttgg tccataagtcataaatagtt

41821 atccttgatc ccatgtcttt tttagagcca tggacagaga gaagcaaaaatataccaagt

41881 tcacactgag ttgtctccct tcatatctct tagcagtcac tgaaaggttatgagactcag

41941 gctgggtttc tatcctctgt ccctgaaacg acaacgttga cctcgtgatcaaccctagaa

42001 tccagagcaa gatctcagac tgtcctctct actaccagac agcacactttgttttggggg

42061 ctgtgtgctt gaaatattag ctatggcaaa aggctttgag tcttatgacaccccaagtaa

42121 cttttacttt aggaatttga aatacagcct tgctgtaatg ctgtctccttaacaaagcag

42181 tacctttgaa atatttaaca acttgaaaag gaaaccgagc ttgaattttcctttcaggtg

42241 ctcaggaaat aatgtttcac ttctgtctga aattcaccat ctcctcagacaaagaaggct

42301 cttatggtaa aaggaatggc attttctcca caattttcga ataaaagataaagagaaaac

42361 agcactgcag cctttttgtt aggatctaac aataaagaaa taatacggttttgccagggg

42421 agagctctgg ttttaagctc agaatacaaa aataggctga caaaattttacaaaggaata

42481 ttctcagcta ccactctgag gatggtagaa agtgaaattt caagaaaattatattatttg

42541 attatttgat gatgattaag ctgattggcc agtcctatgt gaaattctaaagtagaagaa

42601 atgtgatgtt gtcttttctg ctcacctctc ccctcattcc tacccccaaatctctgcctc

42661 taccccaaac ccagcctgac ctttgggaaa ggaatggggg ctgtcacttgcaccgtagct

42721 cctcctgcct gcagtactct ccccccacag tccagcctcc ctctgctcagctaacttttc

42781 ctatagctcc ttctggctac ttctaaggaa ccttccataa tgctgcccaccctctcagta

42841 acagcccctc tactatccct tgattacatg cactgtaatt ggttagtaattgattttatg

42901 tcctctgcca aattatactc catgagagca aaaatcatga gtattatctttaatgtttaa

42961 atctccacaa ctatccccca tataagtcta gagaataaat gaatgagtgaattaatgaat

43021 agaaactcaa gccattatgt tgccactcct aggatatttg gattaactttaactgaagag

43081 taaaaagcat ttacctgtcc taaaggagac ataaaattag tgggagagtatttggagaaa

43141 aaaaagacac tgtaatacat tcttttgtgt tgcctaccct gatgtagtcaggtgtccctg

43201 atatggggtg ggctgaggat ttgaaataaa atacctaatt tgacattgtaagtggaggaa

43261 tcaggatttg aaaccaaatt ggtttgacct aaatcaagct attatgataaggacttgcaa

43321 gaaaaaagga atccataaaa accatatgaa tagctaccaa ttagtaagcatttatatgtg

43381 tcaattacaa agccaaatgc aaatcatgct ttatttatat tagccaccttttatagatga

43441 agaaattgag acctgaatat taaaattgcc tacttttaca tagtaagtaaaggaatcagg

43501 gtttgaaccc aaattggttt cacctaaggt agaaaaccat cccagcaagtctcctattaa

43561 ctggaaccct attgtggtgg cctgagatat aacagtagct gtggaagcgctgtagagtcc

43621 tggccatcct atgtgctcct gatctggtcc ctcctgccac ctgcttctgctccctgtgcc

43681 atccacccat ctggaagtct cccagtgtcc atcttcgggg gagacactcaccagagtttc

43741 cagcttccag ccagtatgga gtgcccctgt cccacagcaa tctcaccgaaatcacagcta

43801 catctgttaa aattaggcta ccaatgagtg atagatgagg gggaaaaataataatagtgt

43861 actaaacaaa acaaatgttt atttttctca cacataaaaa tctagaggttgaagtccagg

43921 gctggtccag aggctccaag gatctgggat ttagactccc tctttcttgtttttccacag

43981 catatggctt ccatttctgg ggccacattg gtccaaaatg tatgctggggctccagccat

44041 tgcatccata tttcagccac aggaaggagg aagtggggaa gaaaggacaggcccctaata

44101 cctgtatagt tcaagaagac tatcccgccc atacttccca accacccttagttgaacaat

44161 gctgtcttaa ttcaagacac tcacatgtct agccaaaaat ctgaattctgttacaaacaa

44221 ggagaataga gatgtgcgcc acctcaatac ctcatccata gctaccttttcctttgtgca

44281 gctgtggcca agtgaaagct gaaggagctg tggtaaccct tctgaagggaggctggggcc

44341 tttcacaaga ggctgcatga ttgacattta tcctgcatgg cctgtgaagtacagagaaat

44401 attttctctt gaagccacat catagcagtg gctgctttgt agcctgattccaccattatg

44461 cctttaaagt gcctagcaat tcagccttca catcatgcaa agaggaatatctcccagtct

44521 ttgtaagatc agcttaattc taaccacctc cttacctccc actgcactcctacacgcaca

44581 cacaaatctt cttcactcag agcagaacca taacccaagc cctaccacctagagactgaa

44641 gaatcaggct catgattaca aatatgcaat aattttttgt gtggataatgtcaatgggga

44701 tgatggtaag agaattcctt ggtttacaca ttgaccctct tccctgtcccttacaatcag

44761 gaaatatttg tcccaacacc ttgtttcttc tgttgcaggc tcctgtggctgtcttgtcat

44821 gatattgttt gcctctgaag tgaaaatcca tcacctctca gaaaaaattgcaaattataa

44881 agaagggact tatgtctaca aaacgcaaag tgaaaaatat accacctcattctgggtcat

44941 tttcttttgc ttttttgttc attttctgaa tgggctccta atacgacttgctggatttca

45001 gttccctttt gcaaaatcta aagacgcaga aacaactaat gtagctgcagatctaatgta

45061 ctgaaaggca aacctttcta taattttaca agggagtaga cttgctttggtcacttttag

45121 atgtggttaa ttttgcatat ccttttagtc tgcatatatt aaagcatcaggacccttcgt

45181 gacaatgttt acaaattacg tactaaggat acaggctgga aagtaagggaagcagaagga

45241 aggctttgaa aagttgtttt atctggtggg aaattgcttg acccaggtagtcaaaggcag

45301 ttgactagaa tcgacaaatt gttactccat atatatatat gtgtgtgtgtgtgtgtgtgt

45361 gtgtgtgtaa gatgtcttcc tatcaaaaag atatcaaagg cacatggaatatattttaat

45421 aaaaacaaat aatatctcta atatatccac acatttgttg ccagatttcagaaaactgag

45481 ctgcaatcgc tttcctaaaa cagtagtgta ttaaatgaac atctataaaatgtatcaaca

45541 cacattttaa aaaatttgtt taaagtatac tcttaggcca ggcgtggtgactcacacctg

45601 taattccagc acttcaggag gccaaggtgg gaagatcatt tgagttcaggagttcgagtt

45661 acagcctggg caataaagtg agaccctgtc actaacaaaa ttaaaaaataaaataaatat

45721 aaaatatagg ctttaaaaaa gcatagtctt attaaccatg tctgttggtcaaaatctgca

45781 aactctaaaa gaagaaaaga agaaaaaacc aagcttaggg tatttttcctcccgtgcctg

45841 agtcccaatt acattcacga cagtactttc aatgaacata attgttaggaccactgagga

45901 atcatgaaaa atgatctctg cttagtacat ttgatgcaaa atgacttattaggggctgtt

45961 tttctagcta tagtgtctcg agtactaata tgcaattatg aaaattatattaaatctggg

46021 attatgacgg tatcactgta tcatcttggt cttgttctgg ctgtcaccaagcatgaccca

46081 ggtcaacttt ttttttcccc tgaattaccc atcaaattga tctgcagctgactaaaggcc

46141 acagctgagc ctggaactga cccttccttc atcctcaacc tgctgtcctccagaaagcac

46201 caaggaaaaa gcagagaatg acagcaaaca gatcactagg cctctgaccacaggtgctga

46261 gtactcagca gccctcatat aataggtttg aaagtactcc ttaaaataaaacactgtttc

46321 cctttggaac tatttacaag gatgaaacaa ccgtatacct gagaaataacttgctctggt

46381 gtcaattcgc tattcgccag cagacatcag aacacaccga gtttccagatgctggttttt

46441 ccccttaaat caggaaatac acctggacaa tttctagaag actacaattcagtctagcca

46501 caaaggggat tttttttttt tggtaacagg ctagagcccg gttctgtaagtctttagctg

46561 aaatggtcca gtacaaaagc actggaaatg agtgggctag gaggacaaggaccgtctcct

46621 gcgtgaggag ttggttggag gtccccaagg ccaggtaccc cctgcactcttattggattc

46681 ctctctgtct tcttggagtt ttgaaaaact ccttcgaaca ccaggcttttttctttagaa

46741 aacaagtctc caatcgttct ctgttccgta gaaagagaaa gaaaacctggagcagctgct

46801 gaaaaatcta atgaggaact aagaggcaaa cccacca

人野生型CLRN1基因组DNA序列的非限制性实例是SEQ ID NO:47。SEQ ID NO:47中的外显子是：核苷酸位置1-544(外显子1)、核苷酸位置28764-29180(外显子2)、核苷酸位置31239-31418(外显子3)、核苷酸位置32481-32519(外显子4)、核苷酸位置44799-46433(外显子5)、核苷酸位置44799-44935(外显子6)和核苷酸位置46128-46837(外显子7)。内含子位于SEQ ID NO:47中的这些外显子的每一对之间，即在核苷酸位置545-28763(内含子1)、核苷酸位置29181-31238(内含子2)、核苷酸位置31419-32480(内含子3)、核苷酸位置32520-44798(内含子4)和核苷酸位置44936-46127(内含子7)处。

跨膜通道样1(TMC1)

TMC1基因编码“跨膜通道样1”(TMC1)。TMC1是钙依赖性氯离子通道，并且可与毛细胞的硬纤毛蛋白中的跨膜O-甲基转移酶同系物相互作用。TMC1中的突变可导致非综合征性感觉神经性听力损失。例如，TMC1中的D572N突变已与耳聋相关联(Kurima等人，Nat Genet30:277-284,2002和Wei等人，J Transl Med 12:311,2014)。

人TMC1基因位于染色体9q21上。其包含24个外显子，涵盖约314千碱基(kb)(NCBI登录号NG008213.1)。从人TMC1基因表达的全长野生型TMC1蛋白的长度为760个氨基酸。

示例性人野生型TMC1蛋白为或包括SEQ ID NO:48的序列。编码野生型TMC1蛋白的核酸的非限制性实例为或包括SEQ ID NO:49。

在本文所述的任何组合物的一些实施方案中，所述TMC1蛋白包含与SEQ ID NO:48具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。

人TMC1蛋白(SEQ ID NO:48)(NCBI登录号NP_619636.2)

MSPKKVQIKVEEKEDETEESSSEEEEEVEDKLPRRESLRPKRKRTRDVINEDDPEPEPEDEETRKAREKERRRRLKRGAEEEEIDEEELERLKAELDEKRQIIATVKCKPWKMEKKIEVLKEAKKFVSENEGALGKGKGKRWFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFILTFSLIMLPEYLWGLPYGSLPRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWMNFRLPLSYFLVGIMCIGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFTSWDYLIGNPETADNKFNSITMNFKEAITEEKAAQVEENVHLIRFLRFLANFFVFLTLGGSGYLIFWAVKRSQEFAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNASFSENSTGPPFFVHPADVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLAIYYLNATAKGQKAANLDLKKKMKMQALENKMRNKKMAAARAAAAAGRQ

人TMC1 cDNA(SEQ ID NO:49)

atgtcacccaaaaaagtacaaatcaaagtggaggaaaaagaagacgagactgaggaaagctcaagtgaagaggaagaggaggtggaagataagctacctcgaagagagagcttgagaccaaagaggaaacggaccagagatgttatcaatgaggatgacccagaacctgaaccagaggatgaagaaacaaggaaggcaagagaaaaagagaggaggaggaggctaaagagaggagcagaagaagaagaaattgatgaagaggaattggaaagattgaaggcagagttagatgagaaaagacaaataattgctactgtcaaatgcaaaccatggaagatggagaagaaaattgaagttctcaaggaggcaaaaaaatttgtgagtgaaaatgaaggggctcttgggaaaggaaaaggaaaacggtggtttgcatttaagatgatgatggccaagaaatgggcaaaattcctccgtgattttgagaacttcaaagctgcgtgtgtcccatgggaaaataaaatcaaggctattgaaagtcagtttggctcctcagtggcctcatacttcctcttcttgagatggatgtatggagtcaatatggttctctttatcctgacatttagcctcatcatgttgccagagtacctctggggtttgccatatggcagtttacctaggaaaaccgttcccagagccgaagaggcatcggcagcaaactttggtgtgttgtacgacttcaatggtttggcacaatattccgttctcttttatggctattatgacaataaacgaacaattggatggatgaatttcaggttgccgctctcctattttctagtggggattatgtgcattggatacagctttctggttgtcctcaaagcaatgaccaaaaacattggtgatgatggaggtggagatgacaacactttcaatttcagctggaaggtctttaccagctgggactacctgatcggcaatcctgaaacagcagacaacaaatttaattctatcacaatgaactttaaggaagctatcacagaagaaaaagcagcccaagtagaagaaaacgtccacttgatcagattcctgaggtttctggctaacttcttcgtgtttctaacacttggagggagtggatacctcatcttttgggctgtgaagcgatcccaggaatttgcacagcaagatcctgacacccttgggtggtgggaaaaaaatgaaatgaacatggttatgtccctcctagggatgttctgtccaacattgtttgacttatttgctgaattagaagactaccatcctctcatcgctttgaaatggctactgggacgcatttttgctcttcttttaggcaatttatacgtatttattcttgcattaatggatgagattaacaacaagattgaagaggagaagctagtaaaggccaatattaccctttgggaagccaatatgatcaaggcctacaatgcatcattctctgaaaatagcactggaccacccttttttgttcaccctgcagatgtacctcgaggaccttgctgggaaacaatggtgggacaggagtttgtgaggctgacagtctctgatgttctgaccacctacgtcacaatcctcattggggactttctaagggcatgttttgtgaggttttgcaattattgctggtgctgggacttggagtatggatatccttcatacaccgaattcgacatcagtggcaacgtcctcgctctgatcttcaaccaaggcatgatctggatgggctccttctttgctcccagcctcccaggcatcaatatccttcgactccatacatccatgtacttccagtgctgggccgttatgtgctgcaatgttcctgaggccagggtcttcaaagcttccagatcaaataacttctacctgggcatgctactgctcatcctcttcctgtccacaatgcctgtcttgtacatgatcgtgtccctcccaccatcttttgattgtggtccattcagtggcaaaaatagaatgtttgaagtcattggagagaccctggagcacgatttcccaagctggatggcgaagatcttgagacagctttcaaaccctgggctggtcattgctgtcattttggtgatggttttggccatctattatctcaatgctactgccaagggccagaaggcagcgaatctggatctcaaaaagaagatgaaaatgcaagctttggagaacaaaatgcgaaacaagaaaatggcagctgcacgagcagctgcagctgctggtcgccagtaa

人野生型TMC1基因组DNA序列的非限制性实例是SEQ ID NO:50。SEQ ID NO:50中的外显子是：核苷酸位置1-113(外显子1)、核苷酸位置56102-56223(外显子2)、核苷酸位置94568-94677(外显子3)、核苷酸位置106121-106263(外显子4)、核苷酸位置126797-126864(外显子5)、核苷酸位置166909-166956(外显子6)、核苷酸位置172743-172914(外显子7)、核苷酸位置178718-178843(外显子8)、核苷酸位置218319-218409(外显子9)、核苷酸位置220644-220725(外显子10)、核苷酸位置230050-230156(外显子11)、核苷酸位置232986-233084(外显子12)、核苷酸位置250613-250755(外显子13)、核苷酸位置266539-266683(外显子14)、核苷酸位置267323-267517(外显子15)、核苷酸位置270086-270265(外显子16)、核苷酸位置270391-270552(外显子17)、核苷酸位置283582-283710(外显子18)、核苷酸位置294343-294410(外显子19)、核苷酸位置299042-299281(外显子20)、核苷酸位置305069-305194(外显子21)、核苷酸位置308651-308729(外显子22)、核苷酸位置308831-30882(外显子23)和核苷酸位置314151-314551(外显子24)。SEQ ID NO:50中的内含子是：核苷酸位置114-56101(内含子1)、核苷酸位置56224-94567(内含子2)、核苷酸位置94678-106120(内含子3)、核苷酸位置106264-126796(内含子4)、核苷酸位置126865-166908(内含子5)、核苷酸位置166957-172742(内含子6)、核苷酸位置172915-178717(内含子7)、核苷酸位置178844-218318(内含子8)、核苷酸位置218410-220643(内含子9)、核苷酸位置220726-230049(内含子10)、核苷酸位置230157-232985(内含子11)、核苷酸位置233085-250612(内含子12)、核苷酸位置250756-266538(内含子13)、核苷酸位置266684-267322(内含子14)、核苷酸位置267518-270085(内含子15)、核苷酸位置270266-270390(内含子16)、核苷酸位置270553-283581(内含子17)、核苷酸位置283711-294342(内含子18)、核苷酸位置294411-299041(内含子19)、核苷酸位置299282-305068(内含子20)、核苷酸位置305195-308650(内含子21)、核苷酸位置308730-308830(内含子22)和核苷酸位置30883-314150(内含子23)。

人TMC1基因序列(SEQ ID NO:50)(NCBI参考序列：NG_008213.1)

1 cagaaactat gagggcagaa cccagcaatc tgtgctttct ttcacaagcc ctccaggagt

61 tgctgaaatt taggaatcat tgccccaaaa agtggccctc ataatgatgc caggtaagga

121 aagacaacat tattacctat gtgtggtgtg ttaacattct ttatgaaaca tgtgtgaaga

181 cctaaatcga agactttctc catgagatat tccctaatca cattagtgaa ataaaactat

241 atttcctcta cttttctact gctacagaaa tctcccccag ttaggatagt cccagtttcc

301 tatttatctt tgtttttctt gcagtgcaca gcatgtcacc cagtaattga taagtttttt

361 tttttttgag acggagtctt gctctgtctc ccaggctgga gtgcagtggc gcgatctcgg

421 ctccccaagt agctgggact acaggcgccc gccatcacgc ccggctaatt ttttgtattt

481 ttagtagaga cggggtttcg ccgtgttagc caggatggtc tcgatttcct gacctcgtga

541 tccgcccgcc tcagcctccc aaagtgctgg gattacaggc gtgagccacc gcacctggcc

601 taattgatat gtttaaatgt taaaattaaa tgcaatgatt tcctaaaata aacaaatgtg

661 ggacaattta ttgcactctg ttcaaattcc cattttgaag tggaattcaa acaaacatga

721 cagtaaaggg ggacagtgag cacagggaca agagaaaagg agaaagggaa gaaatacaga

781 gaactagata ggaggaagtg tcaaagactg atgggtgtaa gccaccttta cctctggata

841 ttggttttcc tttgaattgt ggtatgtggt catattgctt attagttata acatacagct

901 gtcagaagag tttttcaatt aaaatttcaa atgtaatatt aaaactgttt ggattccttc

961 ctactgggca ctggacactg tctgtggagc tgctggaaca gcgctgaata gggtcatatt

1021 ttaaaggaac tcagcctagt gcagtttctc aaccttagca ctattggcctttggggcctg

1081 ataatccttt tttgtgaggg gctgtcctgt gcactgtagg atgtttagcagcatccttgg

1141 cttctactca gtagatgaca gtatcaaccc ccttccccag aagtgacaattaaaaatgtc

1201 tccagacttt tccaaatgtc ccctgaggag caaaattgtc tccagttgaaaaccactggg

1261 ttagtgggag aaacagataa gacagaagtt ctccatacac catgataatgccatgatgcc

1321 atagggctgg caggagtgaa gggaagagca tctcacaaag actcggggggatgcagggag

1381 gaggaaaaat taggaaatga agtgggctga gttgcagtta gcctgtggggaaaatgaagg

1441 agaagggata aggaagaaga ggaggaagga gggaggaaga gtgaggagtaatagggaatt

1501 atagttgacc ttgaacaact tggggtttag ggatgccgac ccttgcgtagtcaaaaatct

1561 gagcttaact tttgactacc ctcacacttt cctaacagcc tactgttgaccagatgcttt

1621 accaataaca taaacagttt attaacacat attttgtatg ttttatgtattatacactgt

1681 attcttacaa taaggtaagc tagagaaaag aaaatgctat taagaaaattgtaaggaaga

1741 aaaaatatat ttactgttca ttaaggggaa gtagatcatc ataaagctcttcatccttgt

1801 catcttcaag ttgaataggc tgaaggagga gggggagaga gaagagactggccttgctgt

1861 cttaggggtg gcagggatgg tagaggtgca ggaggtggaa ggggaggcaggaaaggcagg

1921 cacactcggg gtagctttcg ttgaaagaaa tcttcatatg agtggacccatgcagttcaa

1981 acctgacttg ttcagagtca actgtacttg ttccaggcta agaacagagaataaaaaaaa

2041 aatgtataga ggcctgaaac agcatattat attaaaagaa ctcaaagccggtaaatgctt

2101 tgctactgaa gcataaagtg agaaaggggc atcatgggct ctgaaattgcagccacaagt

2161 ctacagaaca catttttcat agcccaaggt cagtcttcta ttaccctttgcagtgaggtt

2221 atcatcatcc attttcactc gtcagtgctg gggagcccat taaatacttgccactatact

2281 tggtcccaac agttaataga ctgtagcatc ttttatttct tcacctagcctgaaatcagt

2341 tgagcttttg cagaatctta gatatgtcgt ttttttcttc aggtttagaatggggcactt

2401 aaaaagatgc atagtacttg aaaatagaga aagaaaatag catgtagaaatttgtgcctt

2461 tattctgccc aaacgtctca aaaaggaaaa aaataatttt aagggtaaatattgtcatca

2521 atttatctga gctcttttga cttcctttga gcctgaaaaa caggatcagtgtctttttag

2581 tatttaccat agtgcctgat atgtagaagg tgtttgacca atgtttattagataaatgtt

2641 cacttttatt actagtaata ttaaccacat tttaatagag actaataatacatgataaac

2701 ttctcaagga tgcgatctca tttgatcact ataacaaccc aatgaggtaagcgaggaata

2761 gttgttaact ctaatacatg ttatatctta tccttgaccc agtattaccccagtcatgcc

2821 ttcctttccc tgcaatgaaa gaaaaccgat aaacacaaaa tgttgtatcccatataagca

2881 ttcattctta tggtagataa gtaaatggaa aagataggta tgcattctcaatttttttaa

2941 gtcctagaat tataaaacag taaagaagtg agaagagaga gaaatcttaagggaccaacc

3001 tcttgatttt acaggtgaga aaactgaggc cacatagcca tttagtgcagagccaggatt

3061 ataaaccaga tgtttggaat cctatgtggt ggtggacacg aggatatactaattagcgtc

3121 gttaccggaa aattccacat atctctaagg agcagatcac cacacacctgcacagcccaa

3181 gcctggattg tggaggtttt tcttgtagag tttgtctttg atagaaagatacggtccaga

3241 aggccggctt caaggacata agaaagggca tattcaaaac aaatacatgtatgcctattc

3301 ttttaaaccg gtacttaaca atagtatcca ggtgtccaaa tataatagcttatctgtttt

3361 attttttcca gaaaaggaaa caaggtctta gagaggttac attttgcataggattttgtt

3421 agccaagtca gcatctgttt gcatcttaaa aatgagtcat acctattccttgtaagtagg

3481 acaggagggc agctggaatt tcccagctca ctccttgtca ctgcttcctgcctctgctgc

3541 tctttgtcct ccacagcacg cttcattggc taaaaagtga accagatactacattacctc

3601 agggcagttg taagtactga gtcagatgcc ttaggcttgt gtgatgggaagtttagggcg

3661 agaccaatgt cttgctttaa caacagtgtg aataagttaa tttcttttgagattttatta

3721 ctcaatattc cacccagaaa gaaacacaga tgacactcag ccaatcaaaggccatctggg

3781 actgacaaac gcagagcttg ttgtagatga caaggctcag tggatggatcatcactgaaa

3841 gaaagggaaa cagtttgaac tgttgtatct ctctccttgc tcacatgaaaaacaaaaaaa

3901 tccttggcca gttgcggtgg ctcacgcctg taatcccagc actttgggaggcccaggcgg

3961 gcagatcact tgaggtcaga agttctggac cagcctggcc aacatggcaaaaccccgtct

4021 ctactaaaaa tacaaaaatt agccgggcgt ggtggcacac acctgtattcccagctactt

4081 gggaggctga ggcatgagaa ttgcttgaac ctgggaggtg gaggttgcagtgagccaagg

4141 tcgtgccact gcactccagc ctggatgaca gagtgagact ccgtctcaaaaaaaaaaaaa

4201 aattccttaa ccacagacta agtaagcatt attgcacaga gtgtcattcgctaatcttgc

4261 ttgtgcctga actttgaaag caccagcccc ttgctttggg ggctgggggcgtggggtgta

4321 agtgtgtgtg tcctctagaa gaagacaaca ctgagaacag aaggagaggatcttggagat

4381 ttgttaattt cctattgcag ttagccttgt ctggggctct cactttagcacttaaaataa

4441 catactcctt tgcacagatg ttattttttt ctcttcatgt gtacaacttgaattatccaa

4501 tggccttgct ttgaggatat tcatcctatc ttattgatcc tgtcactgtgtaggacaatg

4561 gagaacacag taaaaaaccc tcaatggata ctacttacac taaattaactctatgaattc

4621 aaaatttgaa gatgctactt aatcatgtaa gcctggttct ccaaaacttcatctgccatg

4681 ggaaaaatca aagcttgtaa aatgattaaa cttgtaaagg aattaaactctaggattcac

4741 tcattttata attggtattt tcaccctaag agctttcttt ttcctctctggtgtttaaaa

4801 acaaagtaaa accagacaaa acaagattaa ctaaattaaa acccctgtgactttaaaaaa

4861 tgtagccaag aataatgtgc aagtgtctag ttaggccaat agatatccttaacatacgtg

4921 agctgggaac acaaatgagc atgaagggca aggaagagca ccaccccctgcttcttttcc

4981 tgctcctgtt cttgcagagg gtcaggcttg gagaccacat atggtcagctcaacactcaa

5041 gtccaccaag cagcccatga ggaactcttc cttccagagt tgtgcacaccatgcagtgtg

5101 gtccacctgc agaagcacac aacaggcgct gcctgggcca gaggtccattcaggccatgg

5161 aattggtctc aatgccattt aggcatgaat ccagggtcct gggtaccagacgcatggtct

5221 aggtaggggg tgtcatgtac taggtgagca tggggttccg ctgggcatgttcccttgtct

5281 tgtaggatgt tagctctgag gggcgtggct ggaagaaggc tagccttgagccctctaaaa

5341 ggcagggctc agggcaaagc tcccagttgc tcaggcctgt gggtaatactgcttaaaaat

5401 ccccttgaga acttctttaa aatgcaaata tctcgattct tttgtagttcaaaagcatga

5461 tgattgggtg ttcacaggca tgtgtaagac gtgacaccct ctgaacctccttatgacccg

5521 gtacattacc tgtctgacct gaaaaaaaaa tgcaaatttc tggattctacccgcctcccc

5581 gcactccgac attacgatgt agcagctctg tggtaggatc caggaatctgcctgtgtaat

5641 cacaggttga tattctggtg tttcctggtt ttgctctgct gatttgggggatgtttacca

5701 gcaggagagc agcctctttc ctctgccctc ctcccttgct gccctccccagaccccagtg

5761 actcacgctc ctcctgctcc tcctgttgct ggcctctctg ttgtggttgccagcgctact

5821 ttgcagacgc tgcctgctcc ctgcacgcca acacagattc tgtttccctgcgaccgctgc

5881 tgctgttgtt tgttccgtcc ctggtttatt gtaggagagc tgattgttctgttgccactg

5941 ctaccaagct gcaaacacca ggctcacggt gcaaggggaa ggggcttctcctctgggtgt

6001 tctgcctcta tcgcctaggc tctcaggctt tgttgccaat ggcactgcgagaccctaaac

6061 tatggccttg tgattcccac atctccattt agttctttct tttgttctctaagatctgag

6121 aaggagccca tgtctttcag tgttcctgtt ttcttgcgat acttcccccctccccgactc

6181 cagaatttag ggcaaccttc tgctgtggtc tgaatgttta tttctctccaccccgccaaa

6241 cttatatgtt gaaatcttaa cccctaaggt ggtggtatta gaaactgaagcctctgggag

6301 gtaattaagt tataaggaca aagccctcat gaatgggatt actgttcttataaaaaaaag

6361 gccccagaga gctagctagc tccttccacc atgtgaggac acaacgtgaaggtgctgtct

6421 atgaggaagg gtccctcacc agacaccaat catctggcac attgatcttgaacttcctat

6481 cctccagaac tgtaaacaaa taaatttctc ttgcttataa accataagttcatgattttt

6541 tttttttttt tgagacggag tttcgctctt gttgcccagg ctggagtgcaatggtgtgat

6601 ctcggctcac aacaaactcc gcctcccggg ttcaagcgat tctcctgcctcagcttccca

6661 agtagctggg attataggca tgcgccacca tgcctggcga attttgtatttttggtagag

6721 acagggtttc tccatgttgg tcaggctggt ctcgaactcc tgacctcaggtgatccaccc

6781 gcctcggcct cccaaagtgc tagggttaca gatgtgagcc actgcacctggccaagttca

6841 tgatttttgt aattagcatc caaaatggac taaaaccccc atcctcctgaaggttctgaa

6901 tctgaggacc caagacttgg ctctcagcct taatgtcctg ctcccactattttcaggggg

6961 cccaatataa atttcctgag tttttgaggt ggttgggctt gcagactgacctttagtatg

7021 ccctttgtta catttacaaa atagattgct tacagggtta gacaaatacagttgaccctc

7081 tgtatccctg ccttccatat ccatgggtca aaattatttg gaaaaaaaaatgtgtctgta

7141 ttgaacatgt atagattttt tttttgtata tttcctaaac tatatcgtataataactact

7201 tacagagcat tcatattgta ttaggcatta taagtagtgt agttatgatttaaagtatgt

7261 gagagaatgt gcacaggtta tacagaaata ctacaccatt tttttttttttaatcaggga

7321 ctgaagcatc ttttcagcta tgactttggt atccggtggc gggtggggcggtgggtgggt

7381 cctggaacca ttcctccatg aataccaagg gataactcta attgctaaatcgtttcctat

7441 ttttgtgaac tggtaaagga ctgcatgaga aaggccaaaa attaaagaataatatgctta

7501 ttcaagcccg gtgtggtggc gggcacttgt agtcctagct acttggaaggccgagatggg

7561 cccaggagtt tgaggctata gagggctatg gttgcacctg tgaatagtcactgcacacta

7621 gctcgggcaa catagctaga ccctgtctct aaaaaagaaa aattctgctgtaataaacct

7681 gcacgcataa aatgatgtct atgtgtctat atagtgtgta tatacatatgtgtttaggaa

7741 atgtgtatat atgtgtgtgt gtttgtgtgt gtggatactg tattagttaagacaaaaaaa

7801 tctggcttca tatgttataa aataatgtct ggagctatcc actcaagtgtgctttcttgt

7861 ttctctgttt tttttttttt cctatttcat tcagtggttt tcactgcctttgggaaaaag

7921 tgacacagca aaacacttag aagaatcaaa tgtttatcct ttgagaatgtggtctgtaca

7981 taagagaaaa catttagaat caaattatga gactaaacca gtttccctcacctgcagcta

8041 gataaaaatt tctaagagga aggagagaat caggaaagat tgaagacttgactccctgat

8101 aagggttctg cccgagttct gagaatggag aataaaagac accctccccctctctaatag

8161 attttgtcag tgaaggtcag agaggcccac gaaatcaggt ctggggagcaaggtaaaacc

8221 cagaatttct acatgatcat gttaaagagg gaataaagga atatcattatagtgtatctg

8281 ggcaggtggg catgagacag cctgattgag ttcctgaaat cccaggtcggtgtgggagca

8341 gcagaatatt ttaggtggct gagagctcca tagtttcttt ctttctttctttctttgaga

8401 tggagtctca ctctgttgcc caggctggag tgtagtgacg cgatctctactcactgcaac

8461 ctgtctccct ggttcaagta attatgtctc agcttcctga gtagctgggattacagatgt

8521 gtgccaccac acctggctaa ttttttttta tttttagtag agatgggattttatcatgtt

8581 gcccaggctg gtctcaaact cctgacctca agtgatccac ctgcctcagcctcacaaagt

8641 gctgggatta caggtgtgag ccaccagcag tcccagctac tcaggaggctgaggcagaag

8701 aatcgcttga acccgggagg tggaggttgc agtggaccga gattgtgccactgcactcca

8761 gcctggtgac agagcaagac tccatcttaa aaaaaaaaaa accttctcaaggtattttct

8821 gtgcttcttg ttttctcttt tgtatttttc atctttatat ctttgtgtttcattctggat

8881 aacttttagt gacctgtctc ctagttcact aattctcttt ttagctatgtctagtattat

8941 aatttgttta ttgaattatt aagtttaggt atcaaatttt cagctttaggatatctaatt

9001 tgccacttgt tttctgccat gatttttttt ttttttttga ggtggagtcttactctgtca

9061 cccaggctgg agtgcactgg tgtgatcttg actcactgca agatctgcatcccgagttca

9121 catcattctc ctgcctcagc ctctcaagta gctgggacta caggcgcctgccaccacgcc

9181 cagctaatta ttattattat tattattatt tgtattttta gtagagacagggtttcacca

9241 tgttagccag gatggtctcc atctcctgac cccatgatcc acccaccttggccttccaaa

9301 gtgctgggat tactggcatg agccactgca cctggcttct gccataatttttaaccttga

9361 gttttaccta cttaaacata gcaaacacag ttgtttatat atttatctaataattccagt

9421 atcaggagcc tctggagtct acttttgtct actttcattg ttttttgttttttaaattta

9481 cattaacagt gtctagtctg tatttatgcc tggttacttt tgattgtgtgctagacattg

9541 tttttggcaa ataatttttt aaacacaata tgtacaaatc atatgaagcctagactggtg

9601 ttttgttcac caaaaaagat tttaaattac ttcagttacg ttcctagggacactattaac

9661 tcaggatgat gttaattgaa gtttcagatt tgatattttc caggtcaactggaccaactg

9721 tccctgctat atgatttatt tcctaaagca atatcaagtt cagctctgcacctctcttat

9781 atactatgga gctctcagtc acataaaata ttctgctgct ctcacactgccctgtagttc

9841 ataagaggaa cagtttactg ttaatccgta ttactcttac atctagggtgtagctctttg

9901 agctaccagt ccaaagtgaa gaataattta ctgaattcct actttgtctggctctaggca

9961 ctgatttttt ttaccctctt ggccacctat cttcaattgg aaaatgccctcaattcaaaa

10021 atgctccaag tgccaagctt tcctatctga attcccattt tttcctgtatctggctggca

10081 attcattaga atcctgctag ccctctgatg cttctaagat tttcatcttttatttttatt

10141 tatttattcg agatggagtc ttgctctgct gcccaggctg gagtgcagtggtgtgatctt

10201 ggctcactgc aacctccatc tcctagggtt aagtgattct cctgcctcagcctcccaagc

10261 agctgggact acaggcatcc accagcatgc ccggctaatt ttgtatttttagtagagatg

10321 gagtttcacc atgttggcca ggctgatctt gaactcctaa cctcaggttatctgcctgcc

10381 ttggccttcc aaagtgttgg gtttataggc attagccacc atacccagcctgaagttttg

10441 attaaaaatg ctttactggg ctgggcatgg cagctcacgc ctgtaatcccagcactttgg

10501 gaggttgagg cgggcagatc acttgaggtc aggagttcga gaccagcctgaccaacatgg

10561 tgaaacccca tctctactaa aaatacaaaa attagccagg tatggtggtgcatgcctgca

10621 atcccagcta ctcaggaggc tgaggcagga gaatcgcttg aatctgggaggcagaggttg

10681 cagtgagccg agatcgtgcc actgtactcc agcctggaca acaagagcgagactccgtct

10741 caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaactttaccggaatt

10801 aaagcccagt catcttgaag ccatgatcat gacgctgtgg aagaaccggtgaggtaggat

10861 gagacatatt ctcagatgct atgctgattt ggggctgtga tgattttggaccatagacta

10921 tgatgaggct tcaaaaagag tgcaatagtg tattttaatt tctttggttagattcaaatt

10981 aatcttcaga aagacaaaat gcagatgtag tcttgttaga gcttgctgatgagactaaat

11041 tttccaagtg tttgaggaat gcctaacagg ggaaaggcaa agcaaactatttttaatgac

11101 cttatggctc tgaattgcta aaagggagtc agtccaccag gctcaggctacttggagtag

11161 aggatcctgt ttcagtgaca aactggctca tcccttaatc tgccataaaatgatggctta

11221 gcatacatgt aggagctggg gctaagggag aaggaggtgc tgtgttttgcagaagaagct

11281 acattctgta gtaaggcctg actcttccct ggccttggag gggaaatacttgtgagacag

11341 tggccaggat cagctgaagt gccctctctt cttgctttgc ctatgggacactgagcccct

11401 ttttgtggaa tatattcatc cagagaaccc tcacacctta taatgcataaagtgataaag

11461 gcttggagat ctggagaaac ccaaggtgcg atccctggct ctagaagaaactctgggcag

11521 ccagcatgat ttacttttct ctgctccaaa gactggagga taaattaaaggaaaagaggg

11581 tatgacccag caatccactg gtgcgagttg ttgctttaag caaagactactgcttctctt

11641 cctgattttc ccctgaccat actctcccag aggtgtctcc cagcaaccaccagagttgtg

11701 gttaagtaca cctagccaat ccaataaatc taaaggagat gcagtccacacaaccttgca

11761 tgacttgtca tgtgagttac tgttctggag agacaaactc aggctggaaacttatttgag

11821 atagcttatg aaaacaaaga taatttatga taaggataca ggcactctcatacaatctaa

11881 ggtagaaaaa cagctaagca tcagaacaaa ctggaccaaa gacttaaacacttctgctcc

11941 tttgtgtaat tggtttcatg cgtttctctc tctcccttcc tctctctcttttctctctgt

12001 ggactaggtt tttctacttt tcatatacaa attttaaaaa tacaatttctggccaggtgc

12061 agtgactcac gcttgtaatc ccagcacttt gggaggccga gggaggtggatcacttgagg

12121 ccaggacttt aagaccagcc tggccatcat ggtgaaactc catctctattgcaaatacaa

12181 aaattagccg ggtgtgatgg tgcacgcctg taatctcagc tacttgggaggctgaggcag

12241 gagaatcgct taaacctggg aggcagaggt tgcagtgagc tgagattgtgtcactgcact

12301 ccagcctggg taacagagtg agaatctgtc tcgaaataaa tgaataaataagtaaaataa

12361 acaataaaaa taaataaaga caattttaaa aatttcccaa cattaagtgtcagcaatttg

12421 gagagggaca gctgtctctt gttctctctc ttctccaatt ctcaattcctaggtctgatg

12481 ctttccctgg ctcaactgac tatggttgtg gggtagggcc atgaaacagaaatatcacat

12541 taggatccaa cctttaatta tgtagatgga cagcagttta cagaaaaagtggtggggagg

12601 tggagggagg tgctgaacag acattctaaa agggctccac caaagaaagctatttgttat

12661 atttatgaac attctggaaa attctttcaa ttgtgttcat gaataaattatgattggtta

12721 aaagctaaca cacatgtaga ttatataact tctaaaattt gtatttggtatctgaatcta

12781 tatattattt tggcatgtat agaaaaatcc cagatatttc aaaggctatcattagaaaaa

12841 cgttaatgaa aaggttaatg gaattctata tatttagttc ctgtgagaatgtccagttta

12901 actttcttaa tcaactgatg aagaaacaga actgaaatca caagattataaagatatttt

12961 aacgatgcat ttaggttttc attctaaatg ctgaaaaaag gtatccctgcaaatactggt

13021 taagaaatta agaagtccaa aacccaataa tgtagttggc agcctgttataaagatttag

13081 agtattcaaa gataaaggca aataaaaaga ctacttttta taccagagtagaaacagttt

13141 attttcatga tcactactct tacttcaaat atatctatta tctaagttgatgcttgcaaa

13201 aagtcctgat tcttacacaa aggcagtcga ttcatggatc tcttagagagagagaaaaaa

13261 aaaaagctag ttgggtgtgt tacagttata tgaatcatgt aggatgctgcttaacgctat

13321 atttatcatg gatgaaggca tgttttcagg ggaaactatg agtctacctaaagttaccca

13381 gttcacctct gttccaaggg actcatcttt tcagcatttt gtttagcatgttacaaagta

13441 ccccgatgtc ttctaaacta ttaggattgc aggaggaaac tctcccagagctgctagaag

13501 tcatccttga aagtttggat ttctcccgaa aacttgtatt tctatcattgttttaactat

13561 cttcttgaat cctcttgatc ctgacctaca tgtcctcttc ccttgattgcatttaaattt

13621 agctgcatat aaccttgctc ttttccttct aatccaacct ataaaccatatcaggggagg

13681 atatgtgatt tgtcaatttt gttgcctcac ttcctcctca agaactttcagtggctccat

13741 tttacctctg agattaaatt gcagccactc atcctgagtt ttggtgttccacaatctgac

13801 atatctagtc agctttgtgt tctagtgtgt ttgtgttgct ataaaggaagactgagacta

13861 gatagtttaa taagaaaaga ggttgatttg gctcacaatt ctgcttgctggaagattggg

13921 catttggtaa aagccttagg ctgcttctat tcatggcaga agagtaagcggagccttcat

13981 gtgtggaaat catagggcaa gggaggcagc aagggaggtg tggagaggtgccaggctctt

14041 tttaacaacc acttctcatg ggaactaata cagtgagaac tcactgactctttctacagg

14101 gagggcatta atttattcgt gaatgattct cccccatgac caaaatacctctcattaggc

14161 cccacctcca acattgggat aaaatttcaa catgaggttt gaaggggggacaaacatcca

14221 aactatagca ttctgctttg gccccctaaa acttatgtcc ttctcacattcaaatacaat

14281 catttcttcc taatagtccc taaaagtctt aacttgttcc agcataaactcaaaagtcca

14341 aagtccaaag tatcacctgc gactcaaggc aacttcttta cagctgtgagcttgcaaaaa

14401 taaaaaatga attatattct tccatgatac aatggttgta caggcattgagtaaacattc

14461 ccatttccct aagggagaaa ctggccaaaa gaaagtggta acaggtcccatccaagtctg

14521 aaacccagtg cggcagacat tctttttttt gaggcagagt ctcgctccgtcacccaggct

14581 ggagtgcagt ggtgcgatct cggctcactg caagctctgc ctcctgggatcacgccattc

14641 tcctgcctca gcctcctgag tagctgggac tacaggcagc tgccaccatgcctggctaat

14701 tttttgtatt tttagtagag acggggtttc actgtgttag ccaggatggtcttgatctcc

14761 tgacctcgtg atccgcctgc ctcagcctcc caaagtgctg ggattacagacgtgagccac

14821 cgcgcctggc cagacattaa ttcttaaaac tccaaaataa tttcctttgattccatatac

14881 cacatcctgg gcatagtagt gtgaggggtg ggtcctaagg ccttaggcagccccactctt

14941 tggctttgct gggtgcagcc cacgtgactg ctctcacaga ttgaagcccaatgcctgtgc

15001 ctttttcagg ctgcagttgt atgttgctgg tggctctata attctggggtctggagggtg

15061 gtagccctgc tcccacacct ccaatagata atgcccaagt agaggctgtgtgtggttgat

15121 ctgaccctat ggcagacttc tgcctgcctt cccaggtgtt ccaataaatcctctgaaatc

15181 taggtggaag ctgccaagcc tccaacattc ttgcattatg ggcacctgcagatttcacac

15241 catgaagcca ccaaggctta ccacttacac ccacctaagc agtggctcaaacagtacctg

15301 gggccattgg agccatggat ggagccagag tggccaggat gcagacagcagcatcctgag

15361 gcagcacagg gcagtggtac cccaggcttg tcctgcaaaa ttattttgtcctcctaggcc

15421 tctaggcttg tgatgggagg agcagcctca aaggtttctg aaatgcctttggggcctttt

15481 ttttccaaag tcttggctat tagaacctag ctcccactta gtcatgctaatatctctcta

15541 gcaagtgttt ggctgcatcc ttgaattcct ctcctgaaaa cactctttcttcatctacca

15601 cagggccagg ctgtaaatct tccaaatttt tatgctttac ttggtttttagttacaattt

15661 acaactttag gtcactcatt tgctgccata tctagtttac aatcatatttacaattaaaa

15721 gcagtgtaaa ccaaaaagta tctgagacag gtctcaatca atgtaagggtttattttgcg

15781 atggttaagg accatggccc atgacacagc ctcaggaagt cctgagaacatgtgcccaag

15841 gtagttttgt gtagcttggt tttatacatt ttagggagac agaagttacagacaaaaaca

15901 taaatcaata catgcaaggt atacattggt ttggcccaga aaggcaagacatctacaagt

15961 gggggcttcc aggtcatagg tatattcaaa aatttcctga ttggcaatggttgaatgagt

16021 taagctctgc ctgaacagtt gaagtcagct tgagttaaga taaagaggttggctgggcac

16081 tgtggctcat gcctgtaatc ctagcacttt taggaggctg aggtggtcagattgccacct

16141 gggcaatctg tttgagatca gcctgggcaa catgatgaga ccctgtctttccaaaaaata

16201 aaaaaattag atgggcatgg tggagcacac ctgtagtcct tgctactcgagagactgggg

16261 caggaggatt acttgagccc aggaggcaga ggttgcagtg agctgagattgcaccattgc

16321 attccagcct gggtgacaga gccagaccct gtctgaaaaa aaaaaaaaaaaaagtgaaag

16381 tcaaggttct tgtcatgtgg atgaagcctc caggtagcag gcttcagagtgaatagatga

16441 tgaatgtctc ttattagaac ttaaaaggtg tcagactctc tggaaaaaacttggtaaggg

16501 agagattctc tacagaacac taacttcctc cacaagagac aacattgcagggccttttca

16561 aaatgtcaaa taaatatatt ttgggataaa atacttgtat tgtattgtattgtattgtat

16621 tgtattgtat tgtattgtat tgtatcgtat ttttgagaca gagccttgctctgtcatcca

16681 ggctggagtg cagtggcacg atctcggctc actgtaacct ccgtctccccagctcaagcg

16741 attctcctgc atcagcctcc tatgtagctg ggattacagg tgtccaccaccatgcctggc

16801 taattttttt gtatttttag tagagatggg gtttcaccat gttggccaggctggtcttga

16861 actcttgacc tcaagtgatc tgcctgcctt ggcctcccaa agtgctgggattactgggat

16921 tacaggcatg agccaccaca cctggacaat aaaatacttt tatttcctttaggtcttgct

16981 atgtcatgtg atgctatatc agagtcgggt tcaaatttgg tatcttattgctacaaagag

17041 tctgtcttgt cagtcatatg atctctgttt taatgttaat gctggtcatttgtgtctaaa

17101 ctccaaaggg ggagggtgta ataaggcatg ttgggtaccc tctcatcttgctatggcatg

17161 agctagtttt tcaggtttct ttgggatctc cttgaccaag gggtccattcagttgattgg

17221 gggagtttga attttaattt tgatttccag cagccacgcc acttcttgaatgctgtgttg

17281 cttagaaatt tcttctgctg ctgggcatgg tgactcatgc ctgtgagaggcaggcacttt

17341 ggaaggctga ggtgggcaga tcaattgggc tcaggagttt gagaccagcctgggcaacat

17401 ggcaaaaccc catctctaca aaaaatacaa aaaaaaaaca acaacaaaaaaacaaatcag

17461 ccaggtgtgg tggcatgtgc ttgtagtccc agttactcgg gaggctgaggtgggagaatg

17521 acctcagcct aggagatgga ggtttcaatg atcctagatc gtgccactgcattccagcct

17581 gagtgacaga gcaagatcct gtctcaaaaa caaaacaaaa caaaacaaaatttccgccag

17641 atatcctagg tcatcactct taactgcagc cttccacaaa tccatagggcatggacacaa

17701 cacagccaag tttttttttc taaagcataa catggaaccc tttgctctagttcccagtaa

17761 gtttctcatt tccttctgag acctgctcag ccttgccttt actatctatatttctatcag

17821 cattttggtc aaaaccactt aactaatctc taagaagttc caaactttccctcatctgcc

17881 tgtcttcttc tgagccctcc aggttcttcc aacctctgtc caatgccctgttccaaagtt

17941 gcttccacat tttcagttgt ctttacagca acatttcact acttggtaccagtattctga

18001 ctttgtccat tttgcattgc tttaaacgaa taccggagga tgggtcatttacaaagaaag

18061 gggtttattt ggctcacagt tctgcaagcc tgtacaagaa gcatggtgccaggatttgct

18121 tttggtgaag gcaaggaagc ttccattcat ggcagaaagt gaaggggagcctccatgtgc

18181 agagatcaca tggcgagaga ggaagagcgt gagaggaggg gaaggtaccatggtcttttt

18241 aacagaggta caggcttttg agggaactaa cagattgaga actcgctcactcccacccct

18301 gccagggagg tcattaatct attcatgagg gatccaccca cataacacacacatctcact

18361 aggccccacc tccaacattg ggatcaaatt tcaacatgaa gtttgggagggcgaacatcc

18421 aaagtacagc accttgtttc ttgttgtttt ctaatatttg ttctttatcccaggaaatgg

18481 ggggtaggaa ggtgagttct tggtgtactc taagcagtca tgctcagcctgtactatcaa

18541 attttattcc atttattctt ctgttgaggc ttgcatgact tccctaaggtacaatggcag

18601 agatagccac atgggtagta aaatcagggg cagacagacc agctttctgccaggaattta

18661 cctcagggaa attcctcatc tttgactttc ctcgttctga cttttttttcttttaattcc

18721 acctcctctc caaacctggc actattcctt tccgatcttt atccttgtccttactgtttt

18781 gaagttggct cttatgcctg tttgtctttg caatctgtct ctgcgtcgcgtgttggtagt

18841 catttatttt tgtccctagt catgattccc agaaccttgc tgtggtcattttgatgcccc

18901 accctttgac tattacaaac caggagagct catgcaagtg gccacatgctgtagtggtta

18961 agagcacagg ccccgtagct gaacttgaaa ctcagcatga caacatgctggctgtgtgac

19021 taaggcaaat taaatgacca ctctgtgtcc ttattttctt atacataaaatggagctaca

19081 atagtacctc ctcataggga tgttgtgaag cttcagtgag ttaatacagatataatgatt

19141 agttatctgc ctccattaaa tccaatcatc aatactaccc agctttattaaaacttctga

19201 cttttgtttt ggatgtggcc aggtcctgaa ctgaattgtt ttttccaggtcaaatttaaa

19261 tctaccctcc tttccttttt ctcaatgcca aattgttctt cagtttccatctctagcccc

19321 ataatctttg atttctcttg cccacatgga tggttacctt ttctgaaatgtcatagctct

19381 tacagtgcta gccacctatt ttgatgccaa atctttacac caaccagtgttatcacttaa

19441 tcaattctta catctatgtc ttaacttctc caaccaaact taagacttgttggtgccaag

19501 aatcaaatct catacttttg agttattcaa accatacaga acagtagatactgaataagt

19561 atttgtctga atgaattgtt tgaataactt aaagagccta gaagcggctgggtgcgatgg

19621 ctcatgccta taatccgagc actttgggag gctgaggcgg gccgatcacctgaggtcagg

19681 agttcgagac cagcctgaca aatatgatga aaccccgtct gtactaaaaatacaaaaatt

19741 agccgggcat ggtggcatgc acctgtaatc ccagctactc aggaggctgagacaggagaa

19801 tctcttgaac ccaggaggtg gaggttgcag tgagccaaga tcacaccattgcactccagc

19861 ctgggcaata aaagcaaaac tccatctcaa aaaaaaaaaa agagcctagaagctttccag

19921 ggtggtcttg ggggtattgg ctttagaaga ggaagcttga tagatgaaaatttccagatc

19981 aacggcattt tatgtacttc tcagaaacaa ggtatgacta gactgaaagatctgaagtca

20041 ggaagaaact tcttggtatc agtctgtgcc cttaggaaga agtgaggtcataagctctat

20101 tagcacacat agctgaaaaa ctgaaagagg atgtaagaga aaggattgttaaaaaacaaa

20161 aacaaaaaaa cacaaaaaac caaaaataaa aaatctgggt gaggtatttgcaatactaga

20221 gccaaagaat ttgacctaag aggccgggcg tggtggttca catctgtaatcccagtactt

20281 tgggaggccg aggtgggtgg atcacttgag gccagaagtt tgaaactaacctggccaact

20341 tgttgaaacc ccatgtctac taaatacaca caaaaaaggg cccggcgcggtggctcgtgc

20401 ctgtaattcc agtactttgg gaggctgagg tgggaggatc acctgaggtcaggagatgga

20461 gaccatcctg gctaacatgg tgaaaccccg tctctgctaa aaatacacaaattagccggg

20521 tgtggtggca tgtgcctgaa gtcccagcta cttggagggt gaggcaggagaatcacttca

20581 acctaggagg tggaggttgc agtgagctga ggtagcgcca ctgcactccagcctgggcga

20641 cagagcaaga ctctgtctca aaataaacaa ttaactgggt gtggtggcacacacctgtaa

20701 tctcagctgc tcctgagcct gaggtgggag aatcacttga acccgggaggcagaggttgc

20761 agtgagctga cattgtgcca ctgcgctcca gcctaggggg gagaaaaagaaaaaaaagaa

20821 ttctgatcca ggcactgact cattgagcaa gtcatcttta ctgttcaggcctcagctttc

20881 ttcctttgtt tttttttgag acagagtctc attctattgc ccaggctggagtgcaatggc

20941 atgatttcag ctcactgcaa cctctgccgc ccgggttcaa gcaattcttctgcctcagcc

21001 tcccgagtag gtgggattac aggtgcctgc caccgcgccc agctaatttttgtactttta

21061 gtagagatgg gggtttcact atcttggcca ggctggtctc gaactcctgacctcatgatc

21121 cacccacctt ggcctcccaa agtgctggga ttacagatat gagccaccgcacccagctag

21181 gcctcagttt tctaatgtgt aaaatgaaaa tatgcactag accttcacttgtttttttct

21241 atgtgataat tttttttaaa aaaagaaggt gtcatgttac attttatctttatgtttaca

21301 tttcatcttg taaggttgcc tttgagcctt gacacagtga tttttctcattcaactagtt

21361 tctctcccat ctcaactagt gacctcacca tccactaatt gtttaagccagaaattggga

21421 acttttcctt ggttcctctt ccttgtttac ttcttccatc taccccatgagcaaatccta

21481 tctgttcttc cttaaattta gttcccagat ctatctcctg catctcaggtctatgtactt

21541 cttcccatct cccctgctac tagtctgtcc agagctacaa ccacttcccttatagattat

21601 tggaataacc ttcttattgg tcttcatatt ttcactctga ctcccctctgatcaattttc

21661 tgcaatgcag ccagaattat cttttaaaaa tgtaagtttg agccaggcacagtggctcac

21721 gcctgtaatc ccagcacttt gggaggccaa ggtgggagga tcacctgaggtcaggagttt

21781 gagatcagcc tggccaacat ggtgaaactc tgtctctact aaaaatacaaaaattagctg

21841 ggcatggtgg tgggtgcctg taatcccagc tacttgggag gctgaggcagaactgcttga

21901 acctgggagg ccatatatat ataaagtttg atcacaccac tgtcctgcttaatctttttt

21961 tattttttaa cttttaaatt ttttaagaga agggtctctc tgtgttgcccagactggtct

22021 ctaattcgtg ggctcaagag atcctctcat cttagcctcc caagtagctgggaatacagg

22081 catgtgccac cacacccagt gactttcctt cctaaaatgc ttcaatagtttctttttctt

22141 tttctttctt tctttttttt tttttttttg agatggagtc tcgttctttcacccaggctg

22201 gagtgcagtg gcgtgatctt ggctcactgc aacctctgcc tcccgggttaaagtgattct

22261 tctgcctcag tcttccaagt agctgggact acagcatgtg ccaccacacctcaataattt

22321 tttgtatttt tagtagaaat gggtttcacc atgttggtca ggctggtctcgaacagctga

22381 gcttgtgatc cacccgcctc ggcctcccaa agtgctggga ttacaggtgtgagccactgc

22441 acccagccac ttcaatagtt tctttttgtg cttaacataa agtttaaattcatgtccaga

22501 gcctataagg tgtcatatga ccaggcccct caaggtatat ccacttcactcaagccatgt

22561 ttgtctcatc ttaattcttc aaacacccca cattctttcc taactcaaggtctttgagct

22621 tgctgcttct tccaggtgga ctgatcttag cccttccctt tgttgttgattttttaactt

22681 tttttttttt ttttttgtga gaaagtcttg ctcttgtttt ccaggctggagtgcagtggt

22741 gcaatctcgg ctcactgcaa cctccacctc ctgggttcaa gtgagtctcctgactcagcg

22801 tcctgagtaa ctgggattac aggcacctgc caccacaccc ggctaatttttgtattttta

22861 gtagaaatgg ggttttgccg tgttggccag gctgatcttg aactcctgacctcaggtgat

22921 cctcccacct cggcctccca aagtgctggg attacaggca tgagccagcgctcccagcct

22981 ttttaccttt ttttttttta atttcaatag gtttttgggg aacaggtagtttttggttac

23041 gtgaaaagtt ctttagttgt gatttctgag attttagcac acccatcacctgagcagcgt

23101 acactctacc caatgtgtag ctttttatcc ttcacccccc caagtctttccctgagttcc

23161 caaagttcat tgtatcattc ttatgccttt gcattctcgt agcttagctcccacttacga

23221 gtgagaacat acaatatttg gttttccatt cctgagtctc caattccacccaggttgctg

23281 tgaatgccat taatatgttc ctttttatgg ctgagtagta tttcatgatatatatataca

23341 cacacacaca cacacacaca catatataca cacacacatt tatatgtgtatatatacaca

23401 tatatatata tgtcacattt ctttatccac tcattgattg atgggcatttgtagccctgc

23461 cctttgaatg gctgacttct tcttatgctt cagaattaat actttgtaattacattaata

23521 tgtttttttt aaaaaaaaac cttttacata tatattggtc tgtcacaataatgtataaca

23581 atattatagt ttctgtttta atgacttaac tttggcaaac tggtcaatgatttcattaaa

23641 actgatcttt ttaaaaataa tcagcttcaa tagacagttt aaccagatttgtcaactttt

23701 tgtttttggc acagtctcac tctgttgccc aggatggagt gcagtggtgccatcttggct

23761 cactgcaacc tctgcctcct gggttcaagt gattctcatg cctcagcctcccgagtagct

23821 gggattagag gcacctgcca ccatgcccag ctaagttttg aatttttagtagagataggg

23881 tttcaccatg ttcgccaggc tggtctcgaa tgcctgacct caagtgatctggctccctcg

23941 aactcccaga gtgctgggat tacaggcgtg agccaccaca cccggtctccataaaaaaat

24001 cttaaacaaa aggatatggt tggtgaaata caaatcctat tgcgcagtaattttcacaaa

24061 ttttaaaatt gacaatacct tcgcttcttt cagatcaatt atagtggctttcaaatgtca

24121 tcgctcaaaa aagttcaaat gtcatcgctc aaaaaaaaaa caaaccttcactagaaaatt

24181 aatcataaat tgatggtaca gactgggtgc agtggctcac aactgtaatcccaccacttt

24241 gggaggccga ggtggatgga tcacctgagg tcaggagttc aagaccagcatggccaacat

24301 ggtgacaccc cagctctact aaaaaaaaaa aaaaatgaaa aaattagcccggcgtggtgg

24361 tgcatgtctg taatcccagc tacttgagag gctgagacag gagaatcgcttgaatgcaga

24421 aggcggaggt tgcagtgagt cgagatcata acactgtaat ccagcctgggcaacagaggg

24481 agactcctca aaaaatataa aaataaataa attgatgtta catttggaaaaactgctgaa

24541 attttcttct tctgcaaaaa gttagaaaaa accactgaat gattgaaaacattgacatta

24601 tttaattctt tgctttagag caagtactca gttcttgatt gaagtgattgagggattcaa

24661 acattgtcct tttgttttct tccggtaacg tcagaccagc atattttgttattgctgctg

24721 gctgttttct tcaaaatttg ctttgaaaaa gatgtaaatg gccatttccttatacttgtg

24781 attaaatatt tgttggcctt tccaccagtt ctctgcactg atcttcaagaaaaaatttta

24841 aaacctgcac acaaaatttt aaagactgaa cacagaattt taaagcatgcacatttttca

24901 aagctgtttc tatctctttg gaagtttgtg tctgattaag ttcatctaagacttcactcc

24961 aggaaaaaag ttaacccaga aaagataaat agcctcagca gagagaaaaatctactgatt

25021 ttcttgtgtc tacattttgt tttagatagc ataatacttc aaaagttggtactcatttct

25081 taaactttac tgtgtgcata gcttcaaaat gaatactttg ttgtgtgtgggaaagccttt

25141 tcattgttat acttacaatc ttcagcatgg tccatccgtg aatcttttttaaaattgata

25201 aaaaggccag gcgcgatggc tcatgcccgt aatcccagca ccttgggaggccaaggcaag

25261 tggatcacct gaggtcagga gtttgagacc agcctggcca acatggtgaaacctcgtctc

25321 tactgaaaat acaaaaatca gctgggtgcg ttggcgtgcg cctgtaatcccagctactca

25381 ggaggatgag gcaggagagt ggtttaaacc tgggaggcgg aggttgcagtgagccgagat

25441 tgtgtcactg cactccagcc tgggcaacag agcgagactc cttctcaaaaaaaaaaaaaa

25501 aaatggttaa aaagatgaaa taaaaatttt ccaagttccc ctcaacccccctaaaaaaaa

25561 atcatacatg aagaaacatt tccaaaacag tggagtttgg agattgatttgcacaagcac

25621 aaatgaggat ttaggataaa tttctttgac ttttacctga acactacagtcagtcttggc

25681 catagtttca gcattgccat gtccttggtc atgatagagg ttcatgtccagcatatcaca

25741 attcagtcat atggtgacta ttatgtgagt tcaggagtgt ttatcctagaaatagaaaga

25801 cacccaggaa tgactccttt ctttcaaatt tgctgttctc aaaatgaacatacttaagga

25861 ctttacattt gatcagggta taaaccactg ggaagactaa gtgctcagaaaaagaaccaa

25921 agacttggag ataggaacag agcctgaaat gaacagaaac tattctataccccccatgaa

25981 cctagaaaca aatgtgtata gctaagcgta ttagtccact cgggatgctttaacagaata

26041 tcaataaact ggaatgcttc acagtaaaca tttatttctc acagttctggaggctgggaa

26101 gtccaagatc tggtatctgc tgaggttcct cttactggtt tgcagatggccgtcttcttg

26161 ttctatcctc acatggcaga gagcagagaa cagaccatct cttgtgtctgttcttagaag

26221 aacattaatc ctatttatga gcactctacc ttcgcaacca aaaggcttcatctccaaata

26281 ccatcacttg gagatttagc cttcaacaca ggaattttgg gggtacacaaacattcaatc

26341 catagcactg agtctgtatg tgttgggaac tgattgataa attggaattcttcaaattaa

26401 cttacatgta gaatacagta tttattaaag gataagtaaa aagaaatgtgttaatttata

26461 gtgtatttat tattattaaa agtctatagg gctgggcaca gtggctcatgcctgtaatcc

26521 cagcactttg ggaggccaag gtggggtgga tcacgaggcc aggagtttcaagatcagcct

26581 ggccaagatg gtaaaattcc atctctacta aaaatacaaa aattaattgggcatggtcag

26641 gcgcacgcct gtaatcccag ctacttggga ggctgaggca ggagaactgcttcaatgaac

26701 ccgggaggtt cattcaagat cacgccactg cacttcagcc tgggtgacagagtgagactc

26761 tgtcttaaaa aaaaaaaaaa aaaagtctac agtaactgca attgtttagaatttaagcca

26821 acaagatatg ttttcttttc cgggagttgt attttttatc actgattgtctacaattgac

26881 agtgcatgtc aaaaagcaga cttgtcgtgc tgcagtggct cacgcctgtaatcccagaac

26941 tttgagaggg cgaggcagga ggattgcttg agcccaggag ttggagaccaacctgggcaa

27001 catagtgaga tcccatctct aaaaaaataa aaataaaacc actcatttttgtcaatttta

27061 ttactgcttt taatttttct aaagacgatg tgctgctcca gctctgggtacacacatgcc

27121 cacgagagca agctcatgag agaagaaact acatcccctc tatccacctatatttctaac

27181 gccttgcaca gtagctggca catagtggac atgaaataaa tatttgtggaataaataagt

27241 gaagaagaat tttagaatac tttataagaa acaataaatc ttcagagatcaacatttcaa

27301 attagtaact ttatttacaa acctctcttc tgggttttat tatttactacaagtgcttgc

27361 aagacctgtt attgtacact catgtattcc tatcaaaggt aatcatcagacattatattt

27421 cattaaataa tttaatggtg ctttctgttc tttattcatt aatttttttgtgtgtgtgtg

27481 agaatggagt ttcactatgt tgcccaggct ggccttgaac tccagggttcaagtggatcc

27541 tcctgccttg gcctcccaaa gtgctgggat tacaggcatg aaccaccatgtccaacaatg

27601 ttttctgctc tttagtaagt ctagccatat taaattttat gtgttttttttttctttttt

27661 gagactgagt ctcactctgt cacccaggct ggagtgcatt ggcgcgatctccactcagtg

27721 caacctccgc ctcccagttt caagcaattc tcttacttca gcctcctgagtagctaggat

27781 tacaggcacg taccaccaca tctggctatt tttttttttt ttttttttgagacgaagtct

27841 cactctgttg cccgagctgg attgcagtgg catgatcttg gctcactgcaacctccacct

27901 cctgggttca agtgattctc ctgcctcagc ctcctgagta gctgggactacaggcatgtg

27961 ccaccatgcc cggctgattt ttgtatattt tttaacagag atggggtttcattatgttgg

28021 ccaggttggt ctcgaactcc tgacctcgtg atccacccac cttggcctcccgaagtgctg

28081 ggattacaga tgtgagccac cgagcccggc ctaatttttg tgtttttggtggagatgggg

28141 ttttaccatg ttggccaggc tggtctcgag ctccggacct caggccatccacctacctcg

28201 gcttcccaaa gtgctaggat tacaggcgtg agccactgtg cccagctcatattacatttt

28261 aaatggaggt agaatatcaa cctgaattca ctaagagaat gcaggacaaattgccctgat

28321 atcctgacac aaaggtgaag caggactttt ttgtaatttg aggatttaaaagcatggttg

28381 ctccaggcca ggcgtggtgg ctcctgcctg taatcccagc actttgggaagccgaggcag

28441 gcggatcatt tgaggtcagg agttggagac cagcctggcc aaaatggtgaaaccctgtct

28501 ctactaaaaa tacaaaaatt agctgggcgt ggtcaggcgc ctgtaatcccagctacttgg

28561 gaggctgagg caggagaatt gcttcaagga acccaggaag cagaggttgcagagcccata

28621 tcgtgccact gcactctagc ctaggtgaca gagcgagacc agcctggccaacatggtaaa

28681 accccgtttc tactaaaaat acaaaaaatt agcagggcaa gctggcgggcgcctgtaatc

28741 ccagctacac gggaggctga ggcaggagaa tggcgtgaac ccaggaggcggagcttgcag

28801 tgagctgaga tggcgccact gcactccagc ctgggcgaca gagggagactccatctcaaa

28861 aaaaaaaaaa aaaaaaaaag tatggttgtt ccagtcctgg gaaattgaaatagggggtaa

28921 aaaggctggt gggtgtggta ggcagaataa ttacttcttc cctctcccaagatgttcagg

28981 tcctattccc catcctattc cctggaacct atagctagat tgccttatggggcaaaagga

29041 atttttcaag tgtgactaaa tttagaatca tgagttagag agattatcctggattatctg

29101 tgtgggttta atgtaatcac aggggtccct agaaagaaaa gagggaagcagaaaagccaa

29161 aggagatgga atgatgggag ttgagatcag tcagatttac agatgcaatattgtttccta

29221 taaattctgt ggtgaaagaa atgctatatt gttgctggct ttgaagatggaggaaggggc

29281 tgagagtgaa ggaatgcaag tgaccttaaa ttggaaaaga caagaaaataattggccctg

29341 tagaggttat aaaagaaggg tggtccttct gacacactga ttttagtccgatgagattga

29401 ttttgaactt ctgacttcca aaaactgtaa gacaatacat tagtgttattgtaaaccact

29461 acatttttgg taatttgtta cagcaatagg aaacttatat agtgggccctgggatccatc

29521 tgccctagcc gtttatctaa aacaaaagat cttataggga aagcaaacaaacaaacaaaa

29581 aatacagaaa caaagcaaaa caaagcaccc ctatgctctg agcttgggcctggtaagggc

29641 actatgagcc catgatttag catgttgctg ggaaatctcc ttccccctgttgagttgcca

29701 gaatcgtgga agcagatggt gtgggggatt caggctcctc cactgcttttctcagccaga

29761 cctttgagga gagcttggct gaagtcttcc aagctttatc cccttgtagccattgttttg

29821 agccatctca aacattaagt agctcttgag ggttgaattg agtccttcctaaagacagac

29881 taaagtccta gtctccagga cctgtaaatg ttcccttatt tgtaattaggatgtttacag

29941 atgtaatcaa attaaaatga ggtcataccg gactagggtg ggctctgatccaatatggcc

30001 ggcatcctca taagaagagg agaagagaca tagacacata gggaaaagaccgtgtgatga

30061 tggcagagat tagagtgatg tgtttacaag ccaaggaatg tcaaatattgccggcaatat

30121 cagaaactaa gaaaaaggca tggcacagat tgtctctgag agcctctcagagagtatggc

30181 cctgctgaca ccttagtttc agaggtctag catccagaac tctgagagaacagatttgtg

30241 ttgttttaag acacccacca tgtggtaatt tattacagta gcccttaaactaacacagtg

30301 accttgtgtc ttctgccaga gggatttgat cacactggtg aggaagggtcctggtccata

30361 ataacccaaa tttctgccag ggaagaggag attgaaaggt cccagtgatcttggcctatt

30421 tacttgggag ctcttccaca gaacaaatga actcctgaag atgagctgctacaaggattc

30481 tgtgctttgg acagaattgc acttgtctct tccccctgct gtcactccctgactaggaaa

30541 ggtccaagct gtgaaggaat cccccccaga agagacttgt aagcattaaagacctgtgga

30601 aaactaagag ggagggtgga tagaggagtc tggagaccga ctaaccttctgagctgctta

30661 ttgcctgaag tgggggtgga gtgggctgca aacactgttg tatttgggggacacatcaca

30721 gatgcttatt tgcaccttgg actttgtcag gacactctgg ttacagcacaactttgtgaa

30781 catggatcac aagatacttg gaaaagcagt gtttgcatta atcagattaggattagctaa

30841 aattttaatt aaagaaccag agagtacttc agaggcaagg agatgatagttacctgggat

30901 tacttgctat ttgtgaaacc aaccagctga ccacttgtgt tgtttgtcccaaggtataat

30961 aataactaga tgtttgcata ttgtgattgt ttctgttcgg atttaatggctgatctattt

31021 atcatattaa aagagggatc aagttcaaag atttcaatgc tctttatcttctttctatat

31081 atgatattta tttttaaatg tccatattaa atatacatat atacacacgattctcagaat

31141 tacgaagaat gtgctgtgta gcattcaatt atatatataa ttttttttttgagatggagt

31201 ttccctcttg ttgcccaggc tggagtgcaa cggcatgatc tcgggtcacagcaacctctg

31261 cctcccaggt tcaagtgatt ctcctacctc agcctcctga gtagctgggattacaggcat

31321 gtgccaccat gctgggctaa ttttgtattt ttagtagaga cggggtttctccatgttggt

31381 caggctggtc tcgaactccc aacctcaggt gatccaccgg cctctgcttcacaaagtgct

31441 gggattatag gcgtgagtca ccaagcctgg ctccaattct gtatatttttaaatgtaagt

31501 ataaagatca aagatacaaa gtatattcac atatcagttt ccatgttgttattattatta

31561 ttatttgcca ttttaaccat ctccagatga agaaaactga atgtaaagttaaatatctcc

31621 ttaactttta ctctatttaa aaagagactg aattatttgt gaggtaacccagttgtagct

31681 gttctactct tctctactgc tagattttgg aagaaccaaa aaggaataaagcaaagcatg

31741 acacagaaga gaaagcagaa ttatactgta gtagtatgct catattttatcagagtttgc

31801 ctgtactttt gctgattttt ttttctccta gcttggacat tttaaaggcttattttaaat

31861 ttatctcttc tgtattaaca ggtgagaagt ggacaaatca atgtataaaaactactatgg

31921 ctatcatcat ttagaatttt gtcttaaaag taattggatt tctggggtcctagacacata

31981 atgattagag atcatgccac cagttctata tggagccatc tcaattcatcctttctcaat

32041 ttatcctttc caggcatttt tcttgaaact gcctaagtac tggcgtctccctacgactat

32101 tatatctgaa aacacattca gttttcaaac cagctgaatt ttatgcctgactattccttt

32161 taacttatac caatgaaaat cctttaataa attcactcac aattgctccactttctcaaa

32221 cagagcacaa agcatctaac aatatttctt catgattgat agcatacacactcttgactt

32281 catattcttc aaaatcttgg tatttttata agcattagtg ccttttttttccccagtcag

32341 aagcactgac ggatttattc tattgggtgt tgtcttctgt ttggtctttagcttttctta

32401 gctgtgatcg tttattgctg aataattaag ggcaattctt tcccactgaaatacttttca

32461 agttaaacat tttttcctta aatttttgcc ccaggctact tctagatccagcgttgttcc

32521 agcttactga gcattccaga gggctaaggt ccaagttagc caaggttttaaaatgttgac

32581 catgtggacc tgaattcttt ccagttacat atttgcatac ttttaacaggagtggttatt

32641 tctcgtcaaa agacagaacg ctggaaatac cagggcaaaa ctatgtgtttttttcttggt

32701 gatatcttga tcttagcatt ttactctctc ttcctggttt ctagcttgacctttgtattt

32761 tagaggagag taatagagta acagtgcact gagaagcaat gggacatgacagaatagttt

32821 cagcagtgaa agtcagggaa gctggtttca accattcatt cacaagcttaaaggactttg

32881 gtatctgact ttgtggatgc cactttctca tctgtaaaat aagggggttggatcgtgtga

32941 tttataaggg gctttcttac tttctaacat tccatattct ataaagacagttaaagtctc

33001 cagagagtaa agaatgtaga aaattcctga aatttactca gctcctttattcctaaatat

33061 ttttgaattc tgaaattatt attattatta ttttttgaga tggagtctcactctgctgcc

33121 caggccaaag tgcgatggca caatctcagc tcactgcaat ctctgctgcccaggttcaag

33181 tgattctcct gcctcagtct tctgagtagc tgggattaca ggcatgtgccaccatgcctg

33241 gctaactttt gtattttcag tagagaaggg gtttcaccat gttggacagggtagtatcaa

33301 atttctgacc tcaagtgatc cacccgcctc ggcctcccaa agtgctggagttacagccaa

33361 agcacctgac ctgaattctg agttttgatt ctgttttttt ttttttttttttgagacaga

33421 gttttgctct tgtcacccag gctggagtgc aattgcacgt tctccgctcacagcaacctc

33481 catctcccgg gttcaagtga ttctcctgcc tcagcctccc aagtagatgggactaccacc

33541 gtgcctagct aataattttg tgtattttag tagagatggg atttcactgtgttagccagg

33601 atggtcttga tctcttgacc tcgtgaccct ccctccttgg cctcccaaagtgctgggatt

33661 acaggcgtga gatactgcgc ccggcccata ctcacagatt tctttgtgatattatctcat

33721 ttgttttcac cacacccaga tgatgtggat ggtaggagaa atcccatgcgaataagtgga

33781 atatgttagt aactgcttcc ttgggtcctt ttgcctctgg acttaactctttttttttga

33841 gacggagtct tgctctgtca cccatgctgg agtgcagtgg cgcaatcttggctcactgca

33901 acctctgcct cccagattca agcaattctc ctgcctcagc ctcccgagtagctgggatta

33961 caggcatgtg ctgccacgcc tggctaattt ttttgtattt ttagtagagatggggtttca

34021 ccatattccc caggctggtc tcaaactcct gaccttgtga tccacccaccttgaccaccc

34081 aaagtgctgg gattagaggc atgagccact gcacctggcc tggacttaactcttaaatga

34141 tgttacccag gaaaaccaat ctatgactaa ggcaaaaaaa aaaaaaaaaaaaaaaaaaaa

34201 aaaagttgca cagagaagag tggaaatatc agtaaatcag aagctaggcaggcctaatcc

34261 ctaatccact tggtgacctt ctgcaaaaca cctttctgtt agccttttcacccgtgaatt

34321 tttttttttt tttgagacgg agtttcgctt tggttagcca gactggagtacaatggtgcg

34381 atctcagctc actgcaacct tcgccttctg ggttcaaggg attctcctgcctcagcctcc

34441 tgagtagctg ggattacagg aacctgccat cacacccaga taatttttgtatttttagta

34501 gagatggggt ttcaccgtgt tggccaggct ggtcttgaac tcctgacctcaggtgatcca

34561 ccttcctcgg ctgcccaaag tgctgggatt acaggcgtga gtcactgtgcctggcttact

34621 tgtgaaatta aagcttcaac ttttactcct taggaacgtc tcacaaatttccacacataa

34681 atctaaagta gacactcctg cttgccaaaa gcatactctc taaaacattggttctcagac

34741 ggacatagtg gctcatgcct gtaatcccag cactttggga ggccgagacgggtggatcac

34801 ttgagatcag gagtttgaaa ccagcatggc caacatcgtg aaaccccatttctactgaaa

34861 atacaaaaaa aattagccag gtatggtggt gcgtgcctgt aatcccagctactcgggagg

34921 ccgaagcagg agaatcactt gaacctggga ggcggaggtt gcagtgagccagatcccgcc

34981 actgcactct agcctgggag atagagcgag actctgtctt ggaaacaaacaaacaaacaa

35041 acaaacaaaa aaattggttc ttgagcaggg caatttcacc tccaaggggacatttgacaa

35101 tggctgggga catttttggt tgtcacatct ggggttgggg agtgaagtgctattggcatc

35161 taatacgtag aggccaggga tgctgctgaa catcctgcag tgcacaggacagcccctgac

35221 agcattaaac agtccaaaat gtcaattgtt ttttgaggtt gagaaacgctggtctaaaag

35281 aaatgacagg acaggtggct tggctcatgc ctatcatccc agcactttgggaggctgagg

35341 cgagtggatc acctgaggcc agtagcttga gaccagcctg gccaacatggtgaaacctct

35401 tctctactaa aaatacaaac aatagccggg cgtggtggcc cacacctgtaatcccagcta

35461 ttcagaaggc caaggcagga gaatcgcttg aacccggggg gcaaagattgcagtgagcta

35521 agatcatgcc actgcactcc agcctgggtg acagagtgag actctcaaaaaaacaaacaa

35581 acaaaaaaac agaaatgact caaatgttta cagtgattac ttctggatgggattatgata

35641 attgtttctc tactgttcta aaaaactttc tgttctttcc aaatgtttaatattgagcac

35701 ttattttaca atcattaaac aaagaaatga caacaactgt taaaaaaaaattcttaagaa

35761 ctgaaaggca aacaccacca ccactaaagc catgtccccc agatctaggttgtgagtcac

35821 atgataccga cttcagaggc agcatgtctc aaggcctctc caatgtgtgtcagggacagc

35881 agtgggagta gggccctctg agtcagcctc tttgacctgg gatgctgcaggagatcttag

35941 caaacattca agattttcac tgagtcattt gcctgtggca ttgatctgctcactcaagtc

36001 ttccggtgtt ttggtgtgag ggaggctaaa gaggaaaaac agctgtttagtttctcattg

36061 atttgtattg tcattgagca atacctggag cccaagtgga tgtcttttattctgtggcct

36121 ccacagctgg gtcagtgtgg aaggcttcag accatgagaa attgttcctgggagtcaatt

36181 attttaataa gtgagatatc agagtatatt cacagaaaga ggcttccctggcactgtaag

36241 ggcagccagg aataaaataa aaatgcttct tcagtgaaga taattgtccaaattgaagac

36301 ataggaaata tttctaattt gcctgtgtat ttggtgaaca tttctctctctctctctctt

36361 tctctctttc tctctctctc tctctttctg tctccataaa tgaagacatgggaaaatcta

36421 ttaaaaatta aattaaaatg caacactttt acataaacaa aattcccaatcactctcctt

36481 actttacctc agcccaacca aatgtgagtt aaatctcttc cctttcccatgggacactag

36541 catcttggtg gcccagctca gtagctaagc atagagtaat gagtttgttaaataatttca

36601 attacattgt ttttgagatt ccagggtcac agggaaattc tgacctgaattatctggatg

36661 aactctcaca attgtgcact gccttgttca aatttgggaa gtgctgagaagcactcatcc

36721 aaggggtaga tctggacttc agctcatgca gcataataga atttcaggctcagtgatttc

36781 taatctgtta ccacttgcca ttttctactt gaagagggca gacaccttcactgatctctg

36841 tttctatttc atcttttgaa aaatcgggat gataatggtt atctggtttacatgctttta

36901 catgcttgtc aggagttatt ttaaagcact ttacaaatat aaaaatgtacaataaaattg

36961 cagagtcgga tgcagcaacc cctgtatcct ttgaggaatc tatcacaattcatacccctc

37021 ccaagccaac ttttctggta ctactctgga aaattgtgct tatacagttaaaatttttat

37081 tttcaaaaag ttgtgtaatt ccctttttca accatttttt tttgttataagaaatgcaat

37141 taaaaacata cttttctttc caaatagaag agcctattct gccttataagaattgtttga

37201 aagattgaag gacaaatgaa gtcatacaac ttctctgata ccatattgaactcaaatgaa

37261 cacattttga ggtaagaaat gagcctggaa gatttttctt ttttttttttttgagatgga

37321 gtcttgcttc gtcgcccagg ctggagtgca atggcgcaat cttggctcactgcaacctcc

37381 gcctcctggg ttcaagtgat tctcctgcct cagcctcctg agtagctgggattacaggag

37441 tgctccacca ggcctcacta attttttgta tttttagtac agatgggttttcaccatgtt

37501 ggccaggttg gtctcagact cctgacctca tgatccaccc gccttggcttcccaaagtgc

37561 tgggattaca ggcgtgagcc actgtgcctg gcaagagata gaatttttcacaaaaataac

37621 tcataccaga aactttgtag gcccccaccg atgcccataa tctttaggaaacaaactcta

37681 gtgtcaccta tttcctgata ccttctgtaa cgaccaggtc atattctgagttcctacagc

37741 actcagtgtt tctcatcgga gctgtagcaa tggagtaata aatggcactgctcaggaaga

37801 gagaattcag aaagaaaaga gcagggccta gaaaaggaac aaacttatcggatgtgtaga

37861 gaaagaatct gcaaagcaag taataaaatc cagaaaaacg tggtatcatggtggtcacaa

37921 aaaaaagagt ggttaaattt tcgaaaatgg agacaaacca ctcaccatgatcgtgccatc

37981 tgaatagaaa cacagaaatg atgacaaaaa aatggctaaa gaaagaaggtcaacaaccat

38041 gtccaatgct ttggatatta agaagtgttc agatggattt agcaagtagaaagtcactga

38101 cacttggtgc acaaccagac ctcaatgtat ttaggaggaa actgttattttggaacaatt

38161 gaaagctttc atttggctga gaaatatcaa ctcattctta aataggtatgttagaaggag

38221 cctctgggcc tgatatctcc ttgattacaa ggaaaatgaa taatagttgcgtctgataac

38281 catgacatat cacccctatg tttgcttgta gctttcagca gctcagaacattgttgaaaa

38341 cactcattat cccaatatcc ccaacaggga agtgttaaaa cctgccttgtgcaactgtca

38401 atctctgatg attagataaa aacaattatg tcatgagttg tagctattgttatttacttc

38461 ccaagagcca gattacacag gtatctgatt gctgaagcaa tgtctggatgtaccacgaaa

38521 ttccacatgc atgtacagta taaacacctc tggctatcac cttatctaattttgatcaga

38581 tacaggttaa tcccctcctg tatctttata tgtcctgaat ttgcctcatccacctgaact

38641 ttgccataat ttactctcaa tttgtatgtg tctgtgatgg agttgttgtcattttccttt

38701 tctttttctt ttttttgagg ccaagtctct ttctgtcacc cagactggagtgcaatgacg

38761 cgatctcagc tcactgcaac ctctgcctcc cgggttcaag taattcccctgcctcagcct

38821 cctaaatagc tgggactaca ggtgcatgcc accatgcctg gctaactttttgtattttta

38881 gtagagacgg ggttttaccg tgttagccag gatggtctct tgatccgcccgcctccgcct

38941 cccaaagtgc tgggattaca ggcatgagcc accgcgcccg gcctcattttctctatctgt

39001 ctgcttaatc aggttttgca agtttcacat ttcctcaact aaacttcattttaccaccca

39061 agcaaacttc attataatta ttttattttt ctgatgacat cagatttctgtaggggtacc

39121 tattagctag agatacttag attttatttt cccagcatgt gactatttcccattctatac

39181 aacacaatgg caagagcagg agtatgtttt tggacaatta aagagagaaaaggccgggcg

39241 cggtggccca tgcctgtaat cccagcactt tgggaggctg aggtgggcagatcatgaggt

39301 caggagatca ggagattgag accatcctgg ctaacacggt gaaaccccatctctactaaa

39361 aatgcaaaaa attagccggg cgtggtggtg ggcacctgta gtcccagctactctggaggg

39421 tgaggcagaa tggcgtgaac ccgggaggca cagcttgcag tgagccgagatcgtgccact

39481 gcactccagc ctgggcggca gagcgagact ccgtctcaaa aaaaaaaaaaaaaaaaaaaa

39541 gagagagaga aaataactca gcttcattta gatttctatt attcttctctgatccatata

39601 gtggatgttc acagaagtgt aggaaccaaa actatgcaag ttaaactgttaattttagaa

39661 gtttatagca gtgatgtgga aggctgacca aagttggcgc tttggtctcactataagcca

39721 tagtaataaa tacattaaca atgtccacaa acaacagtag acaccatttagtaagggctt

39781 gctccaagcc aggcactgtt ttcagcttaa gtctcacagc cttgtgaagtagattctgtc

39841 ccatcttaga gcaagttggt ctgaggatcc tcaagggtaa ggtctcttgccaaaggtcag

39901 cagaggtagt gagttcagaa ctgggattta aatccaggct gttctatttctattccacaa

39961 ttctgcctca actgcttctc tacattttag gcacacgttt gaatactgaaaatttgggtc

40021 acagagttgg agatgtttct tcttctaggc cccaaaccgg agcggggtgcagtggctcaa

40081 gcctgtaatc cgcactactt gggaagctga ggcgggagga tcgcttgagctcaggagttt

40141 gaagatacag tcagctatga tcctgccact gcactctagc ctgggcaacagaacaagatc

40201 ctatctctaa aaaaaaaaaa aaattaaaat tttaacacaa gggcccaaacaagtcaacag

40261 taattacaac atgatcttta ctactgtcta ataacatctc acagtgctttaaacatacgt

40321 agttaccatt ctgtccactt ggttgcctgt aatattaact cagtaagtaggaatacttcc

40381 tgccctgact aatatactca taaatatatg ctctaagtca agggtcttgcaggttctgat

40441 ttaaaaaaca caattttttt gagggtcact ggctttacat tatctcattcttttcaagtt

40501 cctttgtacg taaaacatcc tatgctcagt tatatgatct gttcaacctcctgcttgaca

40561 gatatgaaaa cagtgctctc atgtaattta tgtaatttac atttttacatatttagcagt

40621 acacctttgt gctatgttat attgtttgag aactaatctg tttttctgatggctggaagt

40681 ctaagtgaaa agattataca tgaaaataat tcatgtttat tatcactaggagaaagtaag

40741 acaatttagt ttgattcaca agcatttgaa tccctattgt gtcagacattgtattggaaa

40801 ctggggatac aaggaagata taacctcatc tctcagagtt ccctagttatcccatacata

40861 tatacaatta ttatttgtca attaaatttt ttttaaaaat ttagaaaggagtttccaagt

40921 aagaaaaatc atagcgaaat ggtataattg gtataataac agttaattagctatagtatg

40981 aaaatacaga ggaagatcta actaagttgg ggattattaa agaaaatttaaattagctgg

41041 gtgtggcggc agacgcctgt aaccccagct acttgggagg ctgaggcaggagaattgctt

41101 gaactcaggt ggtggaggtt gcagtgagat gagatcactg ggtaacagaacaagactccg

41161 tctcaaataa aataaaataa aaaataaaga aaattggaca gagatgtggcatttgaactg

41221 tctttcagat taagaagaaa gttactagtt agccaattca aatataagatttacaaacat

41281 agagtacagc atgagcaaag gtgtggaggt acaaaaagaa taatgtttttgaggggagaa

41341 tagcaagtac tctgggggtg gccaaagttt gagttgtgtg gttttggtggtggatggaga

41401 tgcaggaaga ttaggaagta gattgagatc agattgagaa aggtcttccagaccagatga

41461 aaaattttgc catatttagg caatagggag ccccagaaat tgttcaaccatcatcagctt

41521 tacatttcac tatggtaatt tggcttcata agaagcatgg gttggagattgataagagca

41581 gactccaagg ggccaattca ttaaactcaa ctgccaataa tgcaagagacaatgaaagcc

41641 agaatgaaca cagtgaccat ggatgccaga ggcatttcta ggatttttgtagaggactta

41701 agagaccatt tgggagggga ggaaggcaga agataagggg aaagaaggagttgatatctt

41761 tgatgactga tggcactttt gctaagatga agaataaatg gtagcaagaataaattgact

41821 gggcgcagtg gctcatgcct gtaatccaac cattttggga ggctgagatgggtggatcac

41881 ctgaggccag gagctcgaga ccagcctggc caacatggtg aaaccccatctctactaaaa

41941 ataaaaaaaa ttagctgggc atggtggcgg gtgcctgtaa tcccagctattcgggaggct

42001 gaggcaggag aatcgcttga acctcgaagg tggaggctgc agtgaacgagatcaagttat

42061 tgcattccag cctggacaac aggagcaaaa ctctggctca aaaaaaaaaaaaaaaaaaaa

42121 aaagtataaa ttgggggagg ggaggagata taggattcct attggaatgtattgagtttg

42181 agattccagc ctggacatat ggcactcttg aattgtttcc taggcgatcatatcactgtc

42241 ttgatgatat ctttaatcac acatatcact tgtggggaaa gaagaaacttcaagagtttt

42301 acacaccaat cctttacttt gccatctaga caaattatat ttttaccaatgccatttttt

42361 gttgttattt tgtgggttct gcttaaaact tcccctatat ttttctaattatggtaacct

42421 agggaaaaca tcaaattatg ttgataaaat tggctacaat ctggctctaatgataatagc

42481 ttagaatcat gaagcagcaa tattttatcc tgagagcaaa caaactttatcctgaacaca

42541 tgtgttcttt tgccttattc atctaatatt acttgaaact tttatttttccactttgaat

42601 agtagattct gccaagtgtt ttaaaagctt ttctcttttt aggggaggaggggaacagct

42661 tttctccctt ttgtctgata actgaggagt gaagatttaa ttggtgagaaaaatatacac

42721 actataaacc tcagaatgtt cccactgctt ttaatgtttg atgtgcctgacagattaccc

42781 tttcaaaaca gataatagga taggtggtgc tggaaaaaaa cttttccatccaagacaaaa

42841 ccacatggac attgaaaaga actggcattt gcctagacat ttagtgggggacatgtcctt

42901 agggcacaga ttccatagtg aaaggctctt ctcccccttc cacacactccagctctctct

42961 agaaggtata atggaaagaa ctctgagcaa gaatcaggaa gttggcctttgttcctgact

43021 gtgccacttt gtggaactgg gcagaactta cctcattctg tgctttagcagcttcatttg

43081 caaaaattaa tgattacctc aaatgatttc tgattttagc caaaattaaatacagtagtt

43141 ttaaaacaac tgctacatat taactactta cgtatgtaat tttgcactcaaaataaatta

43201 tattatggaa aagaaactca acctatgtta accatccctg tactgatgaggaaactaaga

43261 cttaggaaaa agaagtgatt tactcagtat tgggcagtta gtgagcatttttgagccaag

43321 gtcttacttt aaccagagac ctttgcataa tattgtactg ttactaaacactttctatta

43381 tttgactaga ggaacacaac atattgatgc atttgaaaca ataaaataataaatattttt

43441 ccttaccctc ggcagaaaca ggatgatgag aaacattgac taaaaatttaatcaagcctt

43501 aaggacaaat agtatcacag ttttgaatag gagattgggt accttggaagtaattatgaa

43561 gaggtgtttt aactcagcag taggctcttt cttattcctg ctaggaatgaagaagcacaa

43621 attgaaagtg aagaaggagg aaataaaaca ctgactctat gtgtaagaaaggtgacttgc

43681 aaattatgag gcagttagga aaatgtttat tttttcttat tttataggctgtatatattt

43741 gagaattaat aattgtcctt tggagggtgt gtgtgtatgt gtatgttggagctttgtgtg

43801 tgttttagtc cattttccta ctgctatgtg aagaaatgcc cgagacggtaatttataaag

43861 aaaaagaggt ttaacggact caccgttcca catggctgtg gaggcctcacaatcatggtg

43921 gaaggtgaag gaggagcaaa ggcacatctt acatggtggc aggcaagagcgtgtgtgcag

43981 gggaattgcc ctttataaaa ccatcggatc tcacgagact tattcactatcacaaggaca

44041 gcatgggaaa aacttatccc catgattcaa ttacctccca ccagctcccctcaagacaca

44101 tggggattat gggagctaca attcaagatg agatttgggt ggggacacagccaaactgta

44161 tcagtatgcc tgtgtgtatg catgtgcacg tatataaatt ttttcactagtgactgatgg

44221 accatctata aaataaacaa aagagaagag acagggtctc actttgcctcctaggctgga

44281 atacaatggc atgaccatag ctcattgcag cctctaattc ctgggctcaagtgatcctcc

44341 cttctgagta gctgggatta caggcacgtg ccattatgcc caactaatgttttgtttgtt

44401 tgttgtggag atgggagatg ggagtactgc tatgttactc aggctggtcttgaactcact

44461 cctggcctta agtgatcctc tggctttagc atcctaaacc actacaatcttaaaaaggac

44521 cagtttcctg gattacctct ctccctccat catccactat ctgccgtcaactctatagag

44581 tcaagggcta tccctgcctt ttcaatagaa gccctcaaga agtcactccatagggactat

44641 cttgggcttt gggaagtgta cagggttggg gtgggtggga aggtgaggaggaaaggccac

44701 tgtttcaggt ggggttggag ggagatggaa aatggaccac agaggttcagagaacaggcc

44761 ctttgtggaa agggggagac caaataatgc tgcgttgtga aaggtgaaacaggctgcaaa

44821 cagaaggagc ccacaggaag ccctgctctg agcagctgaa cattctggggtcctcagact

44881 ccgataaaaa agcacattta gcctacagct ttatgccctt cctcctacccttgtggactc

44941 tgccacagac atgccctcca gattgattct atccacttgt ctctagtctactgctactat

45001 tttagtctaa ggccttctcc ccgctttcct gggttatggt cacagactcctatctgagtt

45061 cccagcacca ggtgcccagt tgttttcatc tcttaacaca ttccacatattatagcaaga

45121 gagatctttc tcaaatgcaa atcagacctt gttgcatccc aatctcaacccctttagttg

45181 ctcttctctt tgccctcatg gtcaagttca agctctctag tgtgggggcagatgttcctt

45241 tataattttt ctgcttatgt ctcctgcctc aggcctcaca attctccacctcacagatga

45301 tgtctcagcc atgatgagtt cctctcaaat cctttaggtt tcagagatgtcatttcccct

45361 gggaacattt tcctgactcc tcgttccaag catatgtctg tctttatgttcccatagcac

45421 ctgatcattg gatcatggta gggtttatca cggtctcgta tttgtctgcttacttgtctg

45481 tattcttcac ttctcaaata tgtcttcttt gttcatcact gtaactcctttccccagaat

45541 gttctcagat atttacaccc atcttccccc tctgtgaagg gaataaatggatatataaca

45601 ctgtattagt ccattctcat gccactatga agaaatatcc aagactgggtaatttataaa

45661 gaaaagaggt ttaaatgatt acagttctgc atggttgggg agaactcaggaaacttacaa

45721 ttatggcaga ggcacctctt cacggggtgg cgggagagag aataagtgcaagtaggagaa

45781 atgccagatg cttctaaaac tatcagatct catgagactc actcactatcacaagaacag

45841 cacgggggaa accgcccccc atgatccgat tgcctctacc tggttccaccctagacatgg

45901 tgattatggg aattaaaatc caaggtgaaa ttttggtggg gatacagagccaaaccatat

45961 taagcaccat cctcaaaata gccttccagc tgaagacagc taaggcactcatgtagtctt

46021 attttgtctc agacaaataa ttttaccttt gaatcattgt tcattaatctagattttaac

46081 ctgaggccct aaaaattgtt tatcatcttc tgggagatct tactcctagatggtgtttta

46141 ttccacaggt taaatttaaa cttgggccaa atctccatcc ttgtggcctgtgagtactga

46201 atttgggact gaaagcctgg gactaactgg aagtgtggaa aaggaggagggtgtggcgct

46261 gccctcaatg attttttttt ttttttagga tttctggtgg aaaaggagagacactcagga

46321 atccccagat aaacatggtt tagcttttgt agtcagatcc tttccccaaatttactgctt

46381 ctttctccac cacttctcaa ccccccaaac tgaacttgcc tcttcaacacactcccttgt

46441 gccctataga cagtcacaag cttgacctat agagagcatg tatttcttgaggcaacgaag

46501 gtaggaaacc ctattctaaa atgtttctta cacttttggc tctgtctaaattctccattt

46561 ttcaattaaa atggaaacga gattagaatt ctattctagt tatgaatataatcagaacac

46621 aataaagcag aaagattgct tcaggctctt ctgttaacgt tacatttattcaacaactct

46681 ttatggggac ttgctatgag tgaggcacca ggctaggcac cgcagctacaaaggtgaaga

46741 gaacataggc tcttcttcaa agaaacttac actgtaagct ttatagttatgaaatcatga

46801 ttgcttacct taaatgttct tgacctacat tcttagatat tttgagtcttgagaaatttg

46861 tttatttttt tcattattat acaatgtcaa ttagctcagt ggaatccaagatgttcggct

46921 agccttctga tccaagatag tggaccaaac atttgtattt actcattgtgcccctccata

46981 cttctctgaa ataaaagtgt agatcttcaa aattaaacat atctataaagcaaagggaac

47041 agaaggggac attatcagca gattagacat tccaaaaatt ttttagaaaataaaagctaa

47101 attgaatagt aagacacgga attattagat gtgtttggaa aaccaacagcatgaacaaga

47161 taatccaaga aaaacaagtt gtcccttggt gaaaatggaa ggaatttgagaaatatagaa

47221 gtgaactaaa caataaatac agtcatccct tggtatctgt tggggactgattccaggacc

47281 tccctcagat accaaaattt ggatgcccaa gtctctgata taaaatggtacagtatttgc

47341 atacagccta tgcacatcct actgtatact ttaaatcatc tttagattacttataatacc

47401 taatacaatg taaatgcttt gtaaatactt gttatattgt attgtttagggaataatgag

47461 aggaaaaaaa gtctgttcat gttcagtaca gatgcaactt tttttttttccagaatcttt

47521 ttaacctatg gttggttgga atccacaaat gtagaacccg gctacagagagctgactgta

47581 attaaaacca acagcttcta tttggtatac tgaaagagaa ttgggaaatcattaaatcca

47641 taaaataaga acaggatgga gtgaaaaaag ctggactctg tgacgaaatggacatatgta

47701 tggataagaa tcaggaaagt tttcataaag gaagtgccaa actgagctagttggccaaat

47761 gaactattct ccaggtggat ggggcagggc atttaggcag aggaagcaacaaagcacaga

47821 gtgaagccca ggaaactaca ggtagctgca gggagatgac ggggctacagtgtgcatgga

47881 gagaggccaa catggtgagg taggcaggag gagctcctga agggctccaacctgggaagc

47941 caggctaaag agatggcatt ctatcttgtc agtaataaga agcattgacattttgtagag

48001 atgatgaatt gaggaaggga tttatgtggt catttgtggt tctggctgatccccctgagt

48061 gctgtctgct agaaggattc caagggttaa gtcctgaggc gtgaagaagaaccgatctgt

48121 aagatagctt aactaaggtg gtagcattgg gataagggtg tggggtgtgtgtgtgagggg

48181 gatacaaagt tattaaggtg gtagaattga tggcaacatt catcttgacagagaatacag

48241 gatgaggagc agatttcaga ggaatataat gagccctttt ttagatctttgtgaatgttc

48301 agaaatggca gctggtgttg cataattgca aaattagggc ttagttagttattggcttct

48361 gagaacgtaa ctgcagtttt tttctttccc tctgccccac tctttgaaagggggtggggc

48421 tcaaagagta gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtggtaaatacttatata

48481 caaatttctt tagatttttc tttatctcct tcactccttt tcaacattttggctggttgt

48541 tctgatatta ccaaggtaat ccacaattat ggcaaatatt caaacaaaacaaattataga

48601 aagtccagaa aaaaaaactc tgaaatacct tttccagaga ccaccatcatgaacagtttg

48661 gtctacagaa ttacaaatct tttgaagtat atagtatatt cttttatgtggccattcatt

48721 atattttatg ggatcttagt attattgctt ttaaattcat ttcttatattttaaatttga

48781 aatacttcaa aatatgcaga aaagtagaga aaataacatt aacaccatatacttaccatg

48841 tagatttaag agaaatctac actttgccaa atttcctttt tttttttttttttttttttt

48901 ttttttgaga cagagtcttg ctctgtcacc caggctggag tgcagtggtgcgatctcggc

48961 ttactgcaac ctctgcctct tgggttcaag caattctcct gcctcagcctcctgagtagc

49021 tgggattaca ggtactcacc accatgcttg gctaattttt gtatttttagtagagatggg

49081 gttttgccat gttggccagg ctggtctcga actcctgacc tcaaatgatccacctgcctc

49141 ggcctcccaa agtgctggga ttacaggcat gagccaccgc acccgaccaaatctccattt

49201 ttgtaaataa tttttcagat atagaaaact acccaattat ggctgggcatggtggctcat

49261 ggctataatc ccagcacatt gggaggccaa ggcaggcgga tcatttgaggtcaggagttc

49321 gagaccagcc tggccaacat ggtgaaatcc cgcctctaca aaaaatataaaaattagccg

49381 ggcatggtgg caggtgcctg tagtcccagc tacttgggag gctgagggaggaaaatcact

49441 tgaacctggg aggcggaggt tgcagtgagc tgagatagca ccattgcactccagactggg

49501 tgacagaaca agactctgtc tcaaaaaaaa gaaaagaaaa gtaagaaaactacctgatta

49561 ctattacttc tctctttctc tctctctctc tgtgttctag aggtttgcagtatcctgaag

49621 ctggtgtgaa tcaacctcac gctttttttt tttttctttt tttttgaggtggagtctcgc

49681 tctgtcgccc aggctggagt gcaatggtgc aatcttggct cactgcacctccacctcctg

49741 ggttcaagtg attctcctgc ctcagcctcc cgagtggctg tgattacaggcatacaccgc

49801 catgcccagc taattttttg tatttttagt aaagatgggg tttcaccatgttggccaggc

49861 tggtctacaa atgtatctat ccataagcaa taccgtatat agtaatatttttattattct

49921 attatttcta ttgaatgttt atattcatag tatcacactg tacacatccttttgcaattt

49981 gctttcttta gaagcaacaa tatatttttg agatttatca tgttgctttgtgtagattgc

50041 ttactttttt tttttgatgg agtttccctc ttgttgctta ggctggagtgcaatggcgta

50101 atctcggctc accgcaacct ctgcctcctg gattcaagag atcctcctgcctcagcctct

50161 tgagtagctg ggattacagg catgtactac cacactcggc taattttgtatttttagtag

50221 agatgggctt tctccatgtt ggtcaagctg gtctcgaact cccaacctcaggtgatctgc

50281 ccgcctgggc ctcccaaagt gctgggatta caggtgtgag ccactgtgcttggccaatta

50341 tttacttttt aatttatttt atgatacaca atttgtctct ttatctcactttattttttg

50401 attttttttt ttttaaacca ggatctcact tggtcaccca ggctggagtgcagtggcgtg

50461 atctcggctc actgcatccc ctgcctccca ggtgcaagca attctcctgccttggcctcc

50521 tgagtagcta ggactatagg gtgtaccacc acatctggtt aatttttgtattttagtaga

50581 gatggtattt tgtcatattg gccaggctgg tcttgaactg ctggcttcgagcaatttgcc

50641 cgccttggcc tccaaactct ctttattttt tagatattgt taacggtactatgggcagta

50701 tccttgaaca tctctctttg tataaatgtg aaagacattc atagacatgggactaaagga

50761 ggtgcccata gtcaaccatg ctaggcattg acaaatggct tcctaaaggggtaatacctg

50821 tgtacattgc cactagcaat ttgtacactt tcttgattcc tttcactcttgtcaaaactt

50881 actctttttt aaatttaaaa ttattggcca ggccatggtg gttcatgactgtaatctccc

50941 agcactttgg gaggctgagg caggtggatc acctgaaatc aggagtttgagaccagcctg

51001 gccaaacatg gtgaaaccct gtctctacta aaagtagaaa aattaactgggcatggtggt

51061 gggtgcttgt aataccagat actcgggagg ctgaggcagg agaatcgtttgaacctggga

51121 ggtggaggct gtggtaagcc aagatcacac cattgcactc caacacaggggacagagtga

51181 gactctgtct caaaaataaa ataaaataaa ataattgtca atattgttggttatgaaatg

51241 ctatctcatt attgtttaaa gaggcatttc ccttgataac tagtgaggttgaattttgtt

51301 ttccagatgt gcatgagcca ttggtttttt tctgttatgc attttctattcatatacttt

51361 gaccacatga tatgtgcctg gtcataaccc atcaaactct tctttctctcagatacttca

51421 ctttatggaa atctttttca cgtttatccc tcaaacccag aattttgagtgtcatacctg

51481 ttctaacata aatttgagga aaatgaaggc taattcagaa taaagaactatataagcaga

51541 tggacagtgt gttctcctct aaataggggt gctaggataa gaggcggtaggataaatgca

51601 cagcctcaaa atccaccacc cactaaagac ctcacagtac atgatgacattagcatgctg

51661 tgccagcatt tctacctacc acgatgacct ggaatgaagg acaaaaggggcaattgttaa

51721 gtcctgtgcg taaactttgg aagagaacat accttgcttt aaaccattaagggggcaggc

51781 aatagattcc tgtacagggt ggcttagcca aaagtggctg gtcttgttctcatttatatg

51841 gtttataatg attctaaatc attctcggag aaaaacagac tcatttcatctccctttaat

51901 taggatttct gttactgcaa tattttagtg gcatttatgt caaatgttttcttttgagaa

51961 cttctccctt ttactgtctt ttttctttta ttttaaactt ttattttaggttagggggta

52021 catgtgaaaa ttggttacat aggtaaactc atgtcaagag ggtttgttgtacggatgatt

52081 catcacccag ggattaagct cagtactcaa tagttatctt ttctgctcctctccctcctc

52141 ctactttcca ccctcaagta gaccccagag tctgttgttt tcttctttgtgttcataagt

52201 tctcataatt tagctcccac ttatatgtga gaacacgcag tatatgattttctgttcctg

52261 cgttagtttg ctgatgataa tagcctccag ctccatccat gttcctgcaaaagccatgat

52321 cttgttcctt ttaatttact ttttgctatt ctgattagag agtggccatgctccatgctc

52381 catatggata ttctttggaa acaaagcatt tttgaaatgg taggattggggctagtaaaa

52441 gagaacagaa agaattgtga acagggtctc ctccagtaca gatggttaaagaacacaaat

52501 agggaagtgt gatgagtgac ctccatttaa ttgggcgccc aagctcttggctgctccagc

52561 atgggttgcc atcctgactg atcccttggc tcagaaacag atatggtgctatcaggaaag

52621 caaggccaat atctgaatat tgcagcagag actgctccca tttcagaaagcaacccagat

52681 taaagttgat gattcagttt caataaatgc ttcctttttt ataaaaggcatttaacatca

52741 ctctttcccc tggtaatatg gaattagctt ttgggatcaa ctggaaaatgtcagagggcg

52801 attgtaaaag gccacctgct aaccacagga agctgggctg atacagaatgccaggttaac

52861 ttaaggtcga taatggttac ttccttgtca ctttttacat gcatccttgctctgcagtgg

52921 gggtcataag aagtaagatg catgcaaggt gaatttctag aagtcagcttctctgagaag

52981 tattctctga ccatacattc ctactagtcc ccacatacgc tgctgatctccccatcttca

53041 cccccattgt tgaaattgct ccctcattgt aactgttcac tcatctgtctccaccataaa

53101 gcttaggctc ctagaaagtc aggaccagag ctagtacagt gccccatgttcttatggaat

53161 gattttagtg ccttgagttt ggtgtggtga ccagagctgg tggccaactgtcgtgaggcc

53221 ccagtccttc tttttgtcat gctttccctc ccagcccctc cttgaccactctttcacctc

53281 catctttcta cttatataga gacaaataat aagatgcttg tacaaagggtgtacttgtat

53341 tatcccattt gtgttgatat tccacaacag caaattaggt ttttttgtttgtttgttttt

53401 tgatggagtc ttgctctgtt gcccaggctg gagtgcaatg cgtgatctcggctcactgca

53461 acctctgcct cccgggttca agtgattctc ctgcctcagc ctcccgagtagctaggacta

53521 caggcaccca ccaccaagcc cggctaattt ttgtattttt agtactgacggggtttcacc

53581 atattggcca ggctggtctt gaactcctga cctcaggtga tctgcccgcctcggcctccc

53641 aaagtgctgg gattacacgt gtgagccact gtgcctggcc tgataaggtttaaagattaa

53701 ataccatgtc gttaaatttg caaatctctc gaataggaaa atcaggaacaatgacaacat

53761 tcggagcttc ccagaaggta acaactatgg ggagttttgt gggcatctgagagaagcaca

53821 cacacagatg gtttgccttt cattggtcca ttcttgccca gaaggcgacactaactgaaa

53881 caaagaagcc tcatatgaga aggacatggg gtcacagcag cttttggggtggccctgggt

53941 ccttgatctg gtctttctct ggctcatttt gtattgctca ctttgttacttcacaatcca

54001 gggcttgtga catttttctt ctctggagtg gaaatgacag agctgcagaacacaagtttc

54061 tgattggttc ctatgagtca ggaaagaggg ccagttgaaa ctgggctcacacacacacac

54121 acacacaaac taggctcaca tgtgttttcc catcagctaa acaagttttcagaagtacag

54181 aaataactcg ttggggaagg ggacccagga caatgacaat gtttttgatggtaatgtctg

54241 cagaagtaag gcaggtttcc tctgtgcctg aaaagatggc accatttgaggagatggcat

54301 actcgtggtg gaatcttcat taagatgtca aactaagctg taggaaatcaactctagaaa

54361 acagctctaa tgtgagaaaa catatatcca gttttataga gcaagagctgtgatcatggt

54421 gacatttaac aactgtatta gttggccaag agggtaaaaa tatacttgacctcttagagc

54481 accataaata ctctcagctt gtgggccaac tgtgtcatgg tcttttttctagcccctcct

54541 ctttctccct tccttcttgt ctctctcctc ctctctcttc cctcccctttctcctttctg

54601 accctctttt ctcttctcta tcttctcgaa ccttcccttc ctcctctcctttaggtgctc

54661 agcacctctt tgattcaata aacatttacg gagctccttc ttgtgccaacgactgtacac

54721 agagctggga tgtcaagatg aatcagttac atttcctgcc caatgccaagggatggcttg

54781 atgggttttg accagcccct ccctggactc ccaatttctt ttttttttttttcttttttt

54841 tttttagacg gagtcttgct ctgttgccag gctggagtgc agtggcacgatctcggctca

54901 ctgcagtctc tgtctccctc ccaacttcaa gcgattctcc tgctcagcctctcgagtatc

54961 tgggattgca ggcatgcgcc accacaccca gctaattttt ttgtatttttagtagagaca

55021 gggtttcacc atgttggcca gggtggtctg gatctcctga cctcgtgatccacccgcctt

55081 ggcttcccaa agtgctggga atacagtcat gagccaccgc gcccggtgccctggactccc

55141 aatttctacc tcctggaacg tgctttactc accagccttg gtgttattctgcaatatggc

55201 caactgggat ttttttcaat cttacagaaa ttattctcgg aaatgtttgctatttttttt

55261 taatgaagct acagcataca atttaaggat aaataatgta cttactctgcagctattgtt

55321 tcaagtcaaa tccgctgatt actcctccaa aattcttttc ttaataaaatctctgaccct

55381 ttcctcttcc tgttagaact tctggagcta ccattgttcc tcctcttgggctgctcataa

55441 cctaggggag tcacagtgaa attacttgct ttaaaattct ttaatcactctgcgagttgt

55501 taggaaaagc tgacacatct gatttggaaa ctcccactcc agtggactgttgtgcctcag

55561 cacacaggga cgggtggagc aaaggaacaa gaagccaaaa actctcagggcacttactat

55621 gattgtgtaa aagagagact catcaattaa cacaggtact ggcaagtgcacttcataatg

55681 cctccatttc tagacagatc aaaaacagtg tgccctgtca ataaatgctgagtttctgta

55741 gcagcctgat tgagatcagc taacctttag gccaaaagcg ggattcttccttgctgaagc

55801 ttttggcaaa gcatattgag cttcatgcca gggattagat taactcttgcaaaactggtt

55861 caccaggaac aatgactcag tgtttttttt ttagtatccg gcatattgtgtggagcagct

55921 ataaatatat ttacaagctg gagtttcaag ggaggggagt aatagcttgctgaaaaacat

55981 gccaactgag ttatgggtct tcacgcagcc agcatgctgt gttttgggctctgcctcttg

56041 taatttttag aaattaatta gtttattctt tatttatatt tatttatttatttattttca

56101 gatgggatct tactctgttg cccaggctgg agtgcagtgg tgcgatctcggctctctgca

56161 acctccgcct cccaggttca agtgattctc ctgcctcggc ctcctgagtagctgggattt

56221 caggtatgcc tcaccatgcc tggctgattt ttgtattttt agtagaggcagggtttcacc

56281 atgttggtca ggctggactt gaactcctga cctcaagtga tccacctaagggtactggga

56341 ttacaggcat gaaccactgc acccggcctg ttggttgtaa ttttattttcctcctcaagg

56401 actttgagca cattatcttc tctttaataa cttgtttcca ccctcctttgtgcacgcgcg

56461 cacgcgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtattttctgatctccc

56521 tacgggggca gagagtctca agcaggtatg tccatgttat taacatactgtctgcttatt

56581 aactaactgc accaatgatg aaagccaact gacaaacaag tgatgctcttatccctcctt

56641 cgcaagcaat gaatctgaaa gccaagagaa gttttccttt caacaggaagtgttttggag

56701 tccgaacaac tctgcattta gacagtgcag cttttagtta cagatcttggcaatggggca

56761 ggcagaggga gcggcaacta cagactttgc cgtaggactg ttttctatggagtgtgtgtg

56821 ctctgacgag ctagtgacag gagggaggtt acaaaagcat ttactgaaataaggatttct

56881 aatagaggag ctttttaaaa gtattaaata tgctaatgtg cctagggcatagtcaacaaa

56941 gagttataat acatgtcatt tttcatattt atcaaggaaa ccatgtcacccgcagccttt

57001 ctcaatttct ggcattctga gaaacacact gtagtggtgc ctgagggtctggggaaagaa

57061 gaatagaatg aatggggcat ctcagaatcg taaactcccc cagttgtagttcctttcgat

57121 gttggtcgtt ggatgaattt ccagtttcta ctattgtggt tggattggggagagtagctc

57181 aaattgggaa ttgctttttg aggatctagg gcttctggaa ttctcccagtttctttttac

57241 ctctttatgc tatcttgtct actttgaaaa atcagtagca tccatttgattgcagagctg

57301 aatctttcta tacagtgagg agttgtaatc acattactta taacctgcttatttaacttt

57361 ttaaaggtgc aagtcattgt aacctaagta tttactcaca ctgatccttaatatactccc

57421 ctttcttatc tgcaagcttc tttctctggt ttctcctaac tctgttactgctcatgagtt

57481 taaaactttg tcttctcagt tcctggcttc acctgtttgg tctctgctctccaggactct

57541 gccttggaaa tctgactcac acttctatat gtccctgggg ctcaacttcgggcctggcgc

57601 cagaatcacc caggctccaa gcaagccttg tagactccac tcagtcctttgactcaagga

57661 aatctccact tctaaatggc tctccggttg attctgatgc cagtccagggttgagaacca

57721 ccgctttagc ttctagacac acagccccct cccctttttc ctggagcccctcttgggtca

57781 tgattctatt ttccctattt ctgtactcag aagggataaa aatggaagtgtatgtgaagt

57841 tgctactacg tcccaggtgc tttaaatatg ttattttatt caatcttcacaacagtctta

57901 tgcagtctct atttttattt taagaatgag gaaaacaata cttgggtgcagtggcttatg

57961 tttgtaatcc cagcactttg ggaggccaag gtgggtagat cacttgagcccaggagttca

58021 agaccagcct gggcaacatg gcataaccct gtctctacca acaatacgaaaattagccag

58081 tctcataacc tggtctataa ataaataaat agataaaaat ttaaaaataaaataatttaa

58141 aaagaaaaga atgaggaaaa caagattcag agagccttgg tcatcttcccaaaggtgcac

58201 aattaagaaa tggctaagca ggggttctga ctcagatctg tcagcatctacagctttgct

58261 atttaaaaga gcgtggtccg tggactagca gaatcagtgt cacctgggatcttggtagaa

58321 acacaaatac ttgagtgcca tctcagacgt actgaatcag tttcttcaggggtagggtcc

58381 aggaatatgc attttatgaa ggcctctaaa tgtttctcaa agtttaagaagcatggggaa

58441 ctatatcttt tcctactata tagtcttatc tctttccttg tttctttactccaaagtatt

58501 gccttatttc tttcccagaa acctcactat cagctcactg tgcagccttactcatatctt

58561 cctcaaccag cagttttatt acacacaccc ttctcatttc ctcacattgctcatggtatc

58621 tgactgagta cagggatcca acctggcttt gggttttgca ctgtcttgcctcagtctctt

58681 aatttcttcc tatgtacatt ttaagatatt gaagacacta acttccaaacctcttctcta

58741 aatctgacag tgaagcagtg tgtgtgtgtg tgtgtgtgtg tgcatgccagtgcatacacc

58801 acacatacaa gcacatacac agagttaagt ttggtcacat ttacttcattaattgatata

58861 taccacaact gagaaaaact tactggcatt ctgctccaag cttgaattcccagacgaaaa

58921 acaaacaagc aaacaaacaa ctcctcctta cacaaaaata tctagtggccttggaaaatt

58981 ccatttaaca ttaaattgtg tctcttcaaa gtgaagcagg gtgggcagatttttgaacat

59041 gaatctactg ataacacaac acctcttcaa aactagaatc tcattcagggttaaatgatg

59101 tccaagtcaa acctgagatg ctagcatgat gccccatcct cagtcagaggtttcagggtg

59161 gcaaacaact tttgctcact ctcctctgcc tctctctata tttgcagaaagtccagcttt

59221 cactgcaaaa gttcgataac tctgtaaaac agtttgatcc taacttcaaaagaattttta

59281 tgctatttgg aatacataaa aaatgaattt attccaatac tttagccccataaataatgc

59341 ataatgattg gtgaaagatt agcattttgg agttcaagta cttaaagctttcttggatgg

59401 ataatgcatc acccttaact agcataaggg gaaatagaag gttgacaaggaaaacttaat

59461 ttagggttct ttatttattt ttctctagtt atgtttacct tcccaggttgttttattaat

59521 gccacttttc acaaggatat ttcatgaata aatatcaggt tgtatctctggccatctgtg

59581 atgatcacgt ttttattttt aatgagttgc tcatggatta tatcctaactggaattgcag

59641 tcagtatatt gagatgcatt gactccattt ctgtctttca ttcttctttctcaatgtatt

59701 ctcactggat tagcactctt agccctgagg actcttgggc cagttttattactaaaagaa

59761 gaattacagt tttgctacac agtgaccttg caagaagtat cagcacagctcaatttcaaa

59821 ttctcctcaa atatcaaata tgttcttggt atattttgct tagcagtttattgccttctc

59881 atctccactg tttttcctga gtaacagctc agaaatctat aaataaaacttaataatggg

59941 gagtgactca aaagtctggt tatttttatt agtaaactat tttaggggtgaacacttcac

60001 attttacatt ctcatgctcc acagtgctga aaatagtctg aattttttttgtgtgttagg

60061 ttgatgagaa tatttttgag atgactagca gaaaacagaa tcattaaaacagtgctatca

60121 gttttcatgt tgaataactt tacaggaaat gatagcatct ttttttctttttttgagacg

60181 gagtttcgct cttgttgctc aggatgaagt gcaatggcgc gatctcggctcaccgcaacc

60241 tccgcctcct gggttcaagc gattcttctg cttcagcctc ccgagtagctgggattacag

60301 gcatgcgcca ccatgcctgg ctaattttgt acttttagtg gagatggggtttctccatct

60361 tggtcaggct ggtctctaat tcccgacctc aggtgatcca cccgcctcagtctcccaaag

60421 tgctgggatt acaggcgtga gccactgtgc tcagccgata gcatcttaacaataaacatg

60481 caaagatttg taaatgttgg caaacagcaa gaaaaacata tttagaaaattgtgctatgc

60541 tttaatgtcc tgtctgtacg ataatttact tagctcccta ccttccccccagcccaccag

60601 aatgtttaaa ctgaaattta aagcacagtt gatcttggct tggataggcagcctgcatat

60661 taactgagga tttagttagt atccaggagc agatctactt ctcaaagtgagattcacata

60721 gcccccttgg aagctttcaa atagattgac tagcctttta aaattcctcttctccccttt

60781 cttattgccc ccgccttgtc tagctgtatg ctaacttgct gcatagaatcctgaatttct

60841 ggatttctac atttctagct caatgaatgg ggtaaatcaa aacttaataacactcttgat

60901 tttgaaaagc ttcagtgctt catgtaagac tttttgagaa aagatcattttcatttattt

60961 ctgttttatt tctagcttaa tgattaaatg taagctgttc aatacctttttcaatatccc

61021 acttgttaaa cccacactaa acctcagaaa tattgagtca gtgatctaaatttccattca

61081 aaatttccac aaagcagaag cataaatgtt ttcattgtca ttacaaataaacagacaggg

61141 ctgggcgcag tggttcatgc ctgtaatccc agcagtttgg gaagctgaggtaggcggatc

61201 acttgaggtc aggagtttga gaccagcctg gccaacatgg tgaaacactgtctctactaa

61261 aaatacaaaa aaattagctg gattggtggt gtgtgcctgt gatcccagctactcaggagg

61321 ctgaggtagg agaatcactt gaacctggga ggcggaggtt gcaatgagctgagattgtgc61381 cactgcactc cagcctgggt gacagagtga gacttcatct caaaaaacaa

aaacaaaaac

61441 aaaaacaacc ccttcccctc cacgaaagaa aaccccaaat aaacagacaaatgaaagcaa

61501 tgaaaacagg aaaataattt tgacacctac ttctgggatg ttatgttatgctttgcattg

61561 gttctattta ttagacatgt tcccatcttt attatttaag agcagataaaataacctcac

61621 tacattaatc tcttttgctc tgcctctttc catatgattc ttcactagcagttcccaaaa

61681 caaaaaaatt gtgcaccaaa atcccaactg agactcaatt gtttgctgactcaacaactc

61741 taatgagaaa tcttatacaa gagcttttgt ttcaaaagga agtgccaggaaaattttgct

61801 tccctcaagc aatggcatgt tttctttttc tggacagtga gaaccatgtaattaaacata

61861 ttttcctttg tgctttggct gtcaggaaac tcagagccaa acttgtagcccaagttttat

61921 ggctatgtaa gacattatgg cccatatatc tggactcttc ctttctccttggtattgatc

61981 ttcagtcttg gctttagttt acaaaatatg ccattataaa aaataacagtatctgtaggc

62041 tgtctgaaat tattatggaa aaagtagtgt acaaataaat gaataagtcaattgtttgaa

62101 aaacaatgca tttgtatcag aaataacttt gtgagtggtc ttcaggttcctagtctattt

62161 cattttgata tatatttctt gtgggtttac cacgtgccag acaaagatgttcctggcagg

62221 ggggttaata atgttaacag tactcagtct ttctagtgcc ttacaggctatagaaggaga

62281 aagaaataca aaacaaacta aaataggtat tcaattgcaa caaaagcaacttgatgtagg

62341 ggtacagggg aaggaataat tcattctaca ggcctttaaa agataaagaggtatttcaaa

62401 ggcaaacaat ggagagaaga tcattctaag ctaaggaggt tgcatgaagaaagcataatg

62461 tcactacttt tttttttttt tttgagacag ggtctggctc tgttacccaggctgtagtgc

62521 agtgatgaga tcacaggtca ctgcaacctc caccttcagg gctcaaaccatccttccaca

62581 tcaacctccc aagtagctgg gactacagct gcatgccacc atacccagataatttctttt

62641 attttttgtg gaaacagggt tttgccatgt tgctcaggct ggtcttgaactcctgagctc

62701 aagtgatctg cccaccttgg cctcccaagg tgttgagatt acaggcatgagccaccgcac

62761 ccagcataat gtcatcaaat tgaagtgaga aatgggaatg tcactaccaaccataagtaa

62821 taaacaatag attatcatta actttgctcc tagagaaaga caagtttatttagaggtgag

62881 gcgagtagaa tttttttaag ggaacttctg ggtaatttaa caccatgatccttctcgaat

62941 gccttacaac gtaaaaatgt agttctcctt tttcttttct tttctttttttttttttttt

63001 ttgagacagg gtctcgcttc gttgcccagg ctggagtgca gtgacacaatcttggctcac

63061 tgcatcctcc gccgcctggg ttcaagtgat tctcctacgt cagcctcctgagtagctggg

63121 attacaggcg tgcactacca cgcctggcta atttttgaat ttttagtagagatgaggttt

63181 tgccatgttg gccaggctgg tcttaaactc ctgacctcaa gtgatctgcacacctcgacc

63241 tcccaaagtg ctgggattac aggtgtaagc caccatgcct ggccatttttcttgataaag

63301 gggtgtcatt ggggcttctc ttactcctgt cactcatcat gggtgccatgtctttttttt

63361 ttttttttga gatggagtct tgctctgtcg cccaggctgg agtgcagtggcgcgatcttg

63421 gctcactgca agctccacct cctgggttca cgccattctc cggccgcagcctcctgagta

63481 gctgggacca caggtgcctg ccaccacgcc ctgctaattt tttgtacttttagtagagac

63541 ggggtttcag cgtgttagcc aggatggtct caatctcctg acctcgtgatctgcccgcct

63601 cagcctccca aagtgctggg attacaggcg ggagccactgcgcctggcctgggtgccatg

63661 tcttaattga caaccacaat gaagagagga aggaaagagg aaagaataagacaatacaag

63721 aagaaaaggg aaggaaaagc caatgacaga cattaactgg attttcccacaaagagaggt

63781 catgaggatc aagagcatac agaagtttgc aaaataaaga gtttctctggcttggagttg

63841 accaaaataa gagaaaggtg aagcgagtat aatgtacgga gacttctcctgggagaagtt

63901 gtcagtggag aagttattgg gtcatatagt gatggtgtgc agataggacctggtggtgag

63961 ttgacgagga gccattgcca ttcagccatc aagaatcatg atgtgtgttgtgtaggaatg

64021 gagaggtgag tgtggagtgg atggggcgta gatggagaag caggaggattcgtcatgcac

64081 cctgaggctt gccagtattg atgtcagact tcctccgacc gtgttgccaccctggactgt

64141 ttgactttgg tagctatttt aaaacagcaa gaagagctgc ttgagaagaacctgggggag

64201 atttcacaac cagcagctgc atcgaatctc cctggatgtg tgcttttggaaacaatttac

64261 acaagggctg atttcaacat gcactaatat atacagttta gctggcattttatatggaaa

64321 ctttaataaa atggttctaa ttagtgctta atttacatag attagagagttctacaggcc

64381 cacacagtag ggcttgggga ttttatgtca tttgatggag atgccagtttgattcagata

64441 aagaaccaat tttagggaat actgctgaag tttgcccgac acaaatgaaggagttgtagc

64501 ttgcatttct tttacccact cttgttcagt ggcttgaact agctttctgtctcttccaca

64561 agatttagga caagatggat ttctgtgtca gcatgtagta ggagagctttgattttctag

64621 ttctgtcctg tgtggatctg tatgtagctc agattccccc acaatctaggtcagagaagc

64681 tgctagcctt ggtgcaaagt tttcaaaaag gcttctattc agagagatgaataaggaaaa

64741 actcacaccc tacgtgcgaa ggttgcttaa tgagaggtgt gagatggagctcagttgcca

64801 cttatctctg tagttgggta ccgttgtgca gtctgtgcac tgcccagccatttgcagtga

64861 ccccaaagag gatcatctgg tcatcttgcg gggagagact gtgagttcctgccatgtcac

64921 ttggtataac atgagaaaac tcaaaactct aggcagatct ttgcacctgccctacttttc

64981 tacctgctct cacaatcttc ttgagggtga ccagagtcca agtaactaagtgtaattcaa

65041 tgtggtgaat gatatgattg ctacacagga gtatctatta aggctttcaaaatgtaaaga

65101 ggaagtgact cattcttcct ggtggtggtg gttgcatcaa ttggtgtagtctattgcctc

65161 tctcccatca acaagggaca tttggcaaag tctggagtgt gtcaactgtggggtggtggt

65221 actaccggca tctagtggat agaggtcagg gatgctgctg aacattttacaatgcccagg

65281 acagccctcc cacaataaat tatctggccc aaaatatcag tagtgctgccattgagaaat

65341 ctggttatgt aacagataac tttttttttt tttttgacat ggagtttcactcttgttgcc

65401 caggctggag tgcaatggct tgatctcgac tcactgcaac ctctgcctcctgggttcaag

65461 tgattctcct gcctcagcct cctgagtagc tgggattaca ggcatgcgccaccacgccca

65521 gctaattttg tatttttaat agagacgagg ttttaccatg ttggccgggctggtcttgaa

65581 ctcctgacct cagatgatcc acccacctcg gtctcccaaa gtgctgggattacaggcatg

65641 agccactgtg cccagccaac agataacttt ttaaattctc agctgtttaacccaacaaat

65701 aattattttc ttcctcaagc tgtatgtcca gcatgggttg gcaacatagccctgtttttc

65761 ctagtccctt caagaagtct attgatggaa gatgcatttt tatgtgggcttctaccacca

65821 ctatgagagg gggaaggaaa tttgttggat tgtaccctga attttaaaaagcttctgccc

65881 agaattgaca tatattcttt ccaattgcat tttattggcc acaatccatcatatgaccat

65941 gcctgaattc agagggagta ggtggagaat acatttttaa tttttaattttttttttttt

66001 tttgagacag agcctcactg tcttgcccag gctggagtgc agtggcgccatctcggctca

66061 ctgcaacctt tgcttcccag gtttaagtga ttctcctgcc tcagcctcacaaatagccgg

66121 aattacaggc atgcaccccc atgcctggct aaggtttttc atatttttagtagaaatggg

66181 gtgtcaccat gttggccagg ctggtctcaa actcctggcc tcaagtgacccatcctcctc

66241 agccttccaa agtgctggga ttacaggtgt gagccattgt gcccagagagagtgcatttt

66301 tgtcttgtac ccagaaagag gagagagtga gaataatcat gaactaccctaatgactatc

66361 atgctgatgg taatggtggt tgtaggatgg tgtgagaatt taaagacggcttcactcctg

66421 tcactttgct tacttactgc tgtataacaa actgccccaa acttcagggatgaagctaac

66481 aaaaaaatca tttaatttgc tcatgaagtt gcaatttgga tagggctgtgtagaacagct

66541 cctctctata ccatggggca tcagttagga cagctcaaaa cctgggagtaactcaaaggc

66601 tgggggctat aatcatctga atgcttgctc actcctgtgc tctcatgtcaggcagtggat

66661 gctggctgta gacagagacc tcagctgtgg ctgtcagctt gaccacctactcccagcctc

66721 tacatgtggc tgtttggctc ccttacagta tggtggctgg gttccaaggcagaaagtaaa

66781 tgctgccagt ttcttaaagt ctgtctgcaa attggcacag cattctttctaccatattct

66841 attcatcaag gagttgtaga ggccaatttt aaggggaaga aaaatagaccctatgtttca

66901 atagcaggaa ggtcaaagaa tgtggaggcc ccagaaaact gcttcccaggtaagtgacag

66961 gatagaaaaa caagattttt tttttttttt ttgagacagg gttttgctcttgttgcccag

67021 gctggagtgc aatggcgtga tctcggctca ccacgacctc tgcctcctgggttcaagtga

67081 ttctcctgcc tcagcctccc gagtagctgg gattacaggc atgcgccacccagttaattt

67141 tgtactttta gtagagacag ggtttctcca tgttggtcag gctggtcttgaactcccaac

67201 ctcaggtgat ccgcctgcct tggcttccca aagtgctggg attacaggtgtgagccacca

67261 tgccaggcca gaaaaacaag acttctttag gtggagtttg gggaatgagctttctggaca

67321 agtaaacggc atgcatcaag gcacagaaac atcagagctg catttgaataaattctccta

67381 gctggtctta cctcctagct acttacttct actgttgaca tcaaccttataaacttgcta

67441 gaggctcagt gtggggaaac aaacaaacaa agcctcatga aacgttttgatccaattaga

67501 aaatgtctat taaatacatt gtgtttcaca aatgtgaact attaatacaatctgggtttg

67561 ttccgattta attgtctaaa attatacata attcatcttg ccaacaaatgaaattattga

67621 aaaattaaaa atatcaccac caattttttc tattaaatgt atatttttgtaatgatagct

67681 taagtttcat ctcagtttga gatttagtac actgtggcat tcactctggttggggttcat

67741 ttggctctga gcttcaaggt tcaatttaga cttcaaagca tgtcggacttgacctgaggc

67801 acgtttttaa caatcaggtg cagtttgtaa ggttatgggt tgaggaatagcataaatggg

67861 ccatcctttt tctgattttg agaagagaat gactactaat acccaggtgtgttcttgtct

67921 ttcttgagtc aattctaaca gcattggctg tgggttataa aaccataaaattttacagcc

67981 aaaaacaact ttaaaggtcg tttagatgga acttcttcat tttgcagatgaggaaactga

68041 gaatcagaga caaagtgacc tcagggcatt acaacttact attactatattgaaagagga

68101 agggaagctg gtgcaagttg agggacccac tgatgaactg cagggtatccaatgttgccc

68161 ctgtgtttgg gctgagggag aagcagcttc ttagcttctg ctatgctgacttatcttgtg

68221 atctctgtcc cagcccttgg ctgcctctcc tccttgtccc caggcctgcaccattccatc

68281 tgcctcctga ttattcactg acagctgcct tttccctcac cctttgttctcagtttttaa

68341 aaatccaatg gggagaagct tggattcaaa tgatagcatt ttcagctcatgaaaaattct

68401 ataacaagtg tatttgaccg tttgatctct ggcttctccc acacacttgccctttatact

68461 ctgacagcca taagcttcat ttccttgaag cagattgcaa tttcaatggaaaggaaataa

68521 ttgtgtagct ttcaagctga gttcagttct aaaaaggact gagcaaagctcaatcctggg

68581 ctattgtaga atcttagtca ctgaatcagg cagtgaaaga gctctctccaagcttcatgg

68641 ttatgatctt gaaaaacacc agagctaggt tcaaattcca gccataccatttcctaactg

68701 tgtgattttg gcaaatcaca caaatactta aaattctttc gactcggtttcctcttctgt

68761 aaaatgggaa cactaattaa tgctcacctc aaaaggttgt tcattcattcaacacatatt

68821 cgttgggtgc ctcctgtgtg tcaaactgtt tcagtccagt gaggaagatggacatgaatc

68881 caagagtcac caaaaaaatg taaagtggca cctgtgatga gtcacaaaggggaggtatat

68941 gagaaagtgt gtgacagtat ctaacaggtg agggcattat ataatttattgttgcaaaca

69001 ggacattttt gagcatgtaa gagggtgtgt taattgtcct ggaacaacaggcataaatca

69061 ggactttctg ggcaaactca ggccctaccc cactcttacc tacccttagtataagaggga

69121 aggttgggaa aggctttcct ggggaaggga agaagaaact gagatccgcggaataagtga

69181 ggattcctag gcaaaaagag gaagacagag tggtttaggc caagagagcaaacagtggtg

69241 caagactcta aggcaggaca aagcatggag cctgcagaga acagacagaaggtcagtgtg

69301 atgaagatgg gaggggtgcg tggctttaaa cacaggcccc ttgcttgttggtttgccctg

69361 taggtgttaa gaaatgaggc tatatcaagg tgaattttaa gtagaggtggcacctctact

69421 taagaccaga cttgcagctt taaacatcag tctggctgca aggcagaatggattagcatt

69481 gagtagtagt tctggccttg gctttccaga ggaaacttct aaacaatatcaaagccttgg

69541 tgtcacccac agagatcctg atttaattag tttaggttgg ctcccagtaggttataaagt

69601 gtgtcaggat tgagattcac tgtagaagga agtgtgaata tggagaagaataattacaag

69661 gctattgcag tagcccgggt aagaagtgat ggaataggtt catggcagtgggtttctgaa

69721 gcagtggttc tcaaactgta gtggatttga gtatcacctg gaagtcttatttatttatta

69781 gagatggtct cacactgttg cgtaggctag agtgcagtgg tataatcatagctcactgca

69841 accttgatca gccttcatct cctaggctca agcaatcctg ccacttcagcttcctgagta

69901 gctgggacta caggcatgga ccaccatggc tatttgtttg tttgtttttaatagagacag

69961 ggtctcactc tgttgcccag gctggtctca aattcctggg ctaaagcaagcctctctcct

70021 tggcctccca aagtgctggg attatagcca ctgcaccttg gcacggaaaccttgttaaaa

70081 tgcagatatc tgggtatcat tgatttagta ggtcgtggat ggggcctgagaatttgcatt

70141 tctgacaaat tacctggagg cgctagttgc tagtttagag atcacacttagcatctagtg

70201 ggtagtggtc agggatgctg gtgaatatca tacaatacac agaacagcccttttgctgat

70261 cactgatcga gcaaaaaaac catctgatgt ggtagataac atcaacaggatttgatcagc

70321 agggtaaagg acaactccag gactcttaca gttttctgaa tttcacaactaaatgacgag

70381 tttcactatt cattgacatt caggagacag ccctacagac ctgagaagatggtgaagtca

70441 aagctacaca tatatttgag ggttaccttt gaaacagcta agaggatacatcaagcagga

70501 acatatatgt ggaacctgga agggaagatc attacagata taaacttggggatcattaaa

70561 gccaggaact tatcaatggc atcagtcagt tctcttttct tttactcttatcattggtgt

70621 caaagctctg gcctcttttt gttggttcca ctcaggtgcc gtgatcctccagcctcagca

70681 ccttgctgtg agctctcctt gggaggctgc ctctccctcc tccttcagaatttaccccct

70741 acttctcctt tgggtcccac ctctcaggct tggtcatgtg tggcattagcaagcaggtgt

70801 gcgtgtttcc ttctgaagca caaatcaaag ccatggttat gtatctgtgggattatttgc

70861 taaatggcca cctctcctgc tagattctaa gttgcctgca gtgactggagaacatcccta

70921 ggtatcagat gctcaatgtc ttacacttat ggaaccgtca aagacagctgttaaatgtcc

70981 aatgggtcag ttagggagat ggtggttgtt aaaactgtga tgagttctcaggaagaggga

71041 gaagcagtta cctttgtgaa gcagttgttg gtatttactt agtaatgagattaaatttcc

71101 taggacagtg ggtgtgtgaa ccagcaatag cgccatctgc tggaagtaagtgatacaaca

71161 actattatct tgactaggct cagggctgtt aaaacagtat tgctctgggagaaaagaatc

71221 atttttttta aggttaaaaa tgtgagtaaa attctttaga gtgaagatagaatttctttt

71281 gaaatggttg gaaaaattgg ataattattg aaaatagtgt tcagttttcaaagaggagag

71341 aaaccttcaa gtcactgtaa ttaagagaag ttttattgaa agaacacatggaataaggaa

71401 gttagatatc tccacccaaa accagcattt cagaaaacag aaacaggcaaaaatctggcg

71461 gagtgtggtg gctcatgcct gcaatcccag ccctttggga ggccatggtggaaggatcgc

71521 ttgaagccag gagtttaaga atagcctggg caacatagta agatccccattttctttttt

71581 cttttctttt cttttctttt tttcttttct tttctgagac agagtgttgctccttttgcc

71641 caggctggag cgcaatggca tgatctcagc tcaccacaac ctcccgggttcaagaaattc

71701 tcctgccttg gcctcctgag tagctgggat tacaggcatg caccaccacacctggctaat

71761 ttcgtatttt tagtagagac gtggtttctc catgttggtc aggctggtcttgaacgcccg

71821 atctcaggtg atctgcccac ctcggcctcc caaagtgctg ggattacaggcatgagcccc

71881 cgtgcccagc cccaagaccc ccatttctat tttaaaaaaa aaaaagaagaagaagaagga

71941 aaagaaaaga aaaatggaaa caggcgaaaa cctaggcttc tcaaagactgaagggtattt

72001 tggaactgac tggatattgc tcatctctgg ctggttgtgt tgcagcctcgttggtggcaa

72061 gtgcagaccc tcagtcagtg acctcctttg ttgctcttcc atcaaagggcccccttctcc

72121 tgcccaggca tggtgttact aatatggcga tggtaggggc aggggctgcatctatgacgg

72181 ggagaggtat gagagtatac tcatcattct gctgttgtct ttgttagtttgtttctaatt

72241 tctattgttg gggagaaaga taaattcttc cctaacctct tgggatcttcacctgggtct

72301 aagaattaaa tcactgtaag acaggttaac aggagaaaaa tatatgagttttattgattt

72361 ttacatgtac gcggagaccc tcatgagaca gcagaagacc tgaagaaatggacaaagcag

72421 aaagctctaa taccttttag acagagaaac cataaattca tgaagagctgacaagacaaa

72481 ggggtttggg ccagtggcag taaattgtgg gaattcacta gggaggtgtaaagatagagg

72541 aagataaggg atagtttaga aagtttattt gtacagctcc attgcagcatcaactcccag

72601 tcaatggtga taagagttat tttcttattc tggtacaggg agggcaactttcttaaataa

72661 atctttttgg cttacgacag gtagaagagg gcagatcaca tagccctttccggcatctgc

72721 tgtttctcag gtgactttag ctcaaaataa tcaacatgcc acatcagcaaattttggggt

72781 gacatggcct gtttcgctat gataatggga aagaaatcag actttttaactttgaattag

72841 aaaacacaaa ctttgactat gtcccacaat ttatgtgact gatttcatattctatcacat

72901 ctattttata ttctctcata ttctcctcat gaattttccc ctagaatgttgggggaattt

72961 tgaaatgact tggggggcat gctacaattc gaaaaggaga gagacatactctccaattct

73021 ctccctgcct gcctcacaat gtgcagctct cctctgcttc ttcttcttcttttttttttt

73081 tttgagacag cgtctcactc tgtcacccag gcttgagtgc agtggcgcaatcttggctca

73141 ctgcaagctc cgcctcccag gttcaagtga ttcttctgcc tcagccttccgagtaggtgg

73201 tactagaggt gtgtgccacc acgcccagct aatttttgta tttttagtagagacggggtt

73261 tctttatgtt gaccaggcta gtctcgaact cctgacctca ggtgatctgcccacctcagc

73321 ctcccaaaat gctggaatta caggtgtgag ccaacatgcc tggcctcctctgcttctgat

73381 tcaactgctg ctaccgatag acttactgaa ggatttgaag ccaaatggtattaattttgg

73441 tcagttactt ccctgtatct ggtgtcctca ctagacagaa cttctgtgtatggctacttc

73501 atagaccccg accagcctac atattgtttg ctctaaggtc tagtgccctctcttatttca

73561 ctaagataca gccactgttg gtgggggagt cacataacat ggaacataatcactgtatca

73621 gttcaggtgc tcttgattca agtggattta attatgaggg aatttattccttacataatt

73681 actaagtcta gcattagagt ggcctgcaga tgagggttga tccagtggctcagtgatggc

73741 cagaacgctg tttacttttt ccattctgct atctatgggg ttggcttcatcctgaggttg

73801 ttttcctttc tgtcacaggt tttacatcaa tggggtaaac tagtttacattgtggtaaca

73861 agcaactctc aacttttttt tttttttttt tttttagact gaatcttgctctgttgccca

73921 ggctggagtg cagtggtaca gtcttggctc actgcaactt ccgcctcctgggctcaagtg

73981 attctcctgc ttgagcttcc tgagtagctg ggattacagg catgcaccaccacgctggct

74041 aattttcgta tttttagtag agatggggtt tctttttttt ttttttttctttttgagaca

74101 gaatcttgct ctgtcgccca ggctggagtg cagtggcgtg atctcggctcactgcaacct

74161 ctgcctcctg ggttcaagcg attcttccgc ctcagcctcc caagtagctgggactacagg

74221 cgcatgccac cacgcccggc taatttttgt atttttagta aagacagggtttcaccatat

74281 tgaccaggct ggtcttgaac tcctgacctc gtgatttgcc cgcctcagcctcccaaagtg

74341 ctgggattac aggcgtgagc caccgcgccc agccaactct caactctagtagcttaagac

74401 aacaaagatt tatttcttgc tcttactgtc tgcccatctg tatcaccttctctgcaggac

74461 ccagtttaat ggagcacaca cagaaaaagg tgctggtcac tagggccaagggaacaatgg

74521 ctctggaagg tttttcttga acaattcagt gttccagtct tggagcaatacatcttattt

74581 ctactgttaa atccatggcc agaactaatc atgttgtccc actcaccacaaagccatatg

74641 cagccccacc atgtgctcag gaaagaggaa tgggaagcat ttgatgaacagaaataatga

74701 cttcaacaat tgggactatc agttcacagt ttcaattgta aaaaaaaaaaaaaaaaaaaa

74761 agacagaaat agaaaaagaa caattgaaag tacttgcttt ctcatccacgaaaaaagttg

74821 gtcaaagcct cttagtgtaa gtctatagca gatgatgcct gataaggaattgtacatacc

74881 gttcttcgtg aaaaccaaga gtaccatgta tgtaacatag ttgctttgggcttcttatag

74941 cagttaagag tgtatcagca ggcctccatg gtatttgaat gttaaaagctttcattcccc

75001 ctggaagaaa acacatagct aactaaagaa agaaaaaaga agggaaaaagaacaaagaaa

75061 aagaaccact agagtctctg aaaagagctt atgagatacc tgactgtctgcgccttctaa

75121 gtatgtacca tgaaacctta gattcctacc tcattttgtg atggtgtagaaggcacattg

75181 gccaccagca acccttgtaa atatttgcgg atttgaattt cacaaattgaaacccagact

75241 gctgagggct ttgctgctaa cgtcaaagag ctggggcaac taccacaaaaccacatgtgg

75301 gagacttttt agatgaggag ataggaaatt cctaataaga aaagtttttttgtaaaatac

75361 tttctaatgc tggctcttta gagaagcaca ttttacatgt gcaatggtgcaaagtcctag

75421 cactaagatt tcttcactca cagaaagaaa gaatgatgca ggtgctgttcacatgcggcc

75481 ggaaccatgc ccttgccaag caggtcagcg gggcacaggg actgcgctcctcatgatagt

75541 gcagattggc tcggaagtac tcaattctgt ggagtcacag cgccctctgacagatttcag

75601 tttctggaaa aggaagggcc cccttcaggg tacctgctgt tcaccttccattagattaag

75661 gttgaagagc gagtggccat ttgtaggtac tggtatgaga tgttcctagctacccgcatg

75721 tcagccccgg gaaacggcaa catttcccac ccttcttacc ctgggtcctgagtaggaata

75781 aaagttagtg attcttaggg gcatattgag agctggcaat gatacctctcacaaatccat

75841 cccccagaga taaggggtcc cccatgcctt tgatgtattt gggagctgtgctgtatgtgt

75901 tctctttggc tccccagtgg agaataataa caataacaac cgcgtactaatacaacccag

75961 atgtcagcac agaccctctg ttctctgtct tccctgagat atctgtatcttctcagggat

76021 tactgtcggt tcaggcctgg ctcctgcttt cagcttgtgg gaaaactcactccatcttca

76081 ttccataacc tcacatctcc tatgccagtt cccttctctg tgctccatgctgaaccaaat

76141 gccacactca tcccctttgc tttgaattat atgaaaaaaa gaaaaaaccctcatggggac

76201 tttatgtgta acagtcttca ctgcacattt gataacacag atgggggtttatatcctagc

76261 agagcagata ttgtcaatgg aaaatggaaa caaaacaaaa cacaaaagacaatcttcagc

76321 catcactatg tagcttggct atcatctttt gctttctcct ttacttctggagtcccccca

76381 cataccctca gaaatggaga tagactctac atcaatctct gctctgggaaatctactcac

76441 atatccaaag gcaaactaac aagctcttgc tccgacaacc catcgacttggggtctcatc

76501 cctccctgcc taccagtctc tgtgactgaa aggggcccat acagagacttattttcccag

76561 gaacgtgaat gatatccttc tcctgttcct tgaccttggg aggcagatttgattatggtc

76621 agctttgatt caaagtaagt tttttttttt ttctccctta ggagaatgttgtgaggtgct

76681 gattgttctc tgcttcataa tcgtatcact tattactgat aatctttttctgcccccaga

76741 ggttgctgaa gaatgtagca tatacagtgg acacagagcc ctgataatacaattactaaa

76801 ttctccaagg ttgagggcct ggtcttaggt catgagatta ctgatccttgccttctgcct

76861 gctaggaagg cccaactaat ttcacagtct ttatcagtga accatagtaaagggggacca

76921 gaagagaaaa aggttatgtc ttttgggaaa atgccaaaat catattgtgaaaatccttcc

76981 tactgttctt ctcatgggag ggggaggact ttggacttgt ttctctccttttcctgtaca

77041 tttggggatg tcagaaccgt ctgtttcctc atctacacgt ggttagatgccgacaacaat

77101 ctcttctctt aaaattgctt actattagac cagcagagtg tttggtattaattgagcaag

77161 gaggaatttg taggaaaggc ttggcttaac taggagaggg aatgccagggagaaatctgt

77221 atttcccact atttttttt