Acute Systemic Changes in Blood Cells, Proteins, Coagulation, Fibrinolysis, and Platelet Aggregation After Frostbite Injury in the Rabbit

摘要

Acute systemic blood changes were measured in New Zealand white rabbits after severe and mild frostbite injury to the foot. There was observed after 72 hours in the severely frostbitten rabbits a decrease in erythrocytes, hematocrit, lymphocytes, and albumin and an increase in total leukocytes, neutrophiles, platelets, fibrinogen, and antothrombin-III. Mild frostbitten rabbits showed similar changes except for no changes in the platelets, albumin, and antithrombin-III. In severely frostbitten rabbits after 72 hours the changes in the plasma coagulaton tests were a prolonged partial thrombo-plastic time, an accelerated prothrombin time and increased activities of Factors VII, IX, X, and XI. In mild frostbitten rabbits there were a prolonged partial thrombo-plastin time and an increased actvity of Factor VII. No changes in fibrinloysis were seen in either group of rabbits. Platelet aggregation, studied only in the severely frostbitten rabbits, showed a change only an increase observed in the rabbit model are different that those reported in human frostbite cases. No disseminated intravascular coagulatin was apparent in the rabbit model after frostbite injury.