Propofol and Fentanyl Compared to Midazolam and Fentanyl During Third MolarSurgery

摘要

Fifty-seven patients undergoing removal of third molars with intravenous sedationbetween November 1994 and December 1995 randomly received either propofol and fentanyl (P + F) or rnidazolam and fentanyl (M + F). Twenty-four received P + F and thirty-three received M + F. Pre-operatively, patient demographics, Corah anxiety scores and physiologic parameters were obtained. Ml patients were titrated to the same endpoint for sedation. Intra-operative physiologic parameters, cooperation, alertness and pain scores were assessed. Post-operative recovery and degree of amnesia were determined. There were no statistically significant differences in patient demograhpics and surgical characteristics between groups. The P + F group was statistically significantly less cooperative than the M + F group. Pain during injection of propofol was a significant adverse side effect. Both groups experienced a small percentage of apneic episodes but mechanical ventilation was never required. There was no difference in recovery between groups as assessed by Treiger dot test and psychomotor recovery scores. The degree of retrograde amnesia was higher for the M + F group although the differences were not statistically significant. Sedation was rated good to excellent by the patient, surgeon and observer and there were no statistically significant differences between groups. Propofol appears to be a safe and efficacious drug for use in outpatient oral surgical procedures.